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Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM) is a dedicated mission, launched in December 2020, for gamma-ray transients, including gamma-ray bursts (GRBs) and soft gamma repeater (SGR) bursts in the multimessenger and multiwavelength astronomy era. Since GECAM consists of two independent spacecrafts (or say instruments), and the framework of data analysis for multiple spacecrafts is distinctive from that for only one spacecraft, which is the case for most GRB missions, we developed a dedicated pipeline called Energetic Transients Joint Analysis System for Multi-INstrument (ETJASMIN) for GECAM mission. This pipeline has been naturally extended to incorporate data from other gamma-ray instruments, including the operating missions, such as Insight-HXMT/HE, Fermi/GBM, Swift/BAT, INTEGRAL/SPI-ACS, Konus-Wind, and GRID, as well as the forthcoming missions, such as SVOM/GRM and HEBS. In this paper, we present this pipeline with a focus on the data analysis procedures, methodology, and results in terms of the localization, verification (classification), spectral, and temporal analyses of gamma-ray transients. We show that this pipeline could provide more accurate, reliable, and comprehensive results than that of individual spacecraft, which is beneficial for gamma-ray transients observation.

Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM) is a space-borne instrument dedicated to monitoring high-energy transients, thereinto Terrestrial Gamma-ray Flashes (TGFs) and Terrestrial Electron Beams (TEBs). We propose a TGF/TEB search algorithm, with which 147 bright TGFs and 4 TEBs are identified during an effective observation time of $\sim$ 9 months. We show that, with gamma-ray and charged particle detectors, GECAM can effectively identify and distinguish TGFs and TEBs, and measure their temporal and spectral properties in detail. Moreover, we find an interesting TEB consisting of two pulses with a separation of $\sim$ 150 ms, which is expected to originate from a lightning process near the geomagnetic footprint. We also find that the GECAM TGF’s lightning-association ratio is $\sim$ 80\% in the east Asia region using the GLD360 lightning network, which is significantly higher than previous observations.

Oxidative stress and cardiomyocyte apoptosis contributed to the progression of doxorubicin (Dox)-induced cardiotoxicity. Recent studies identified microRNA-22 (miR-22) as a cardiac- and skeletal muscle-enriched microRNA that functioned as a key regulator in stress-induced cardiac injury. The present study aimed to investigate the role and possible mechanism of miR-22 on Dox-induced oxidative stress and cardiomyocyte apoptosis. Mice were exposed to reduplicative injections of Dox (i.p., 4 mg/kg) weekly for consecutive 4 weeks to generate Dox-induced cardiotoxicity. Herein, we found that miR-22 level was significantly increased in murine hearts subjected to chronic Dox treatment. MiR-22 inhibition attenuated oxidative stress and cardiomyocyte apoptosis in vivo and in vitro, thereby preventing Dox-induced cardiac dysfunction. Mechanistically, we observed that miR-22 directly bound to the 3′-UTR of Sirt1 and caused SIRT1 downregulation. Conversely, miR-22 antagomir upregulated SIRT1 expression and SIRT1 inhibitor abolished the beneficial effects of miR-22 antagomir. In conclusion, miR-22 inhibition prevented oxidative stress and cardiomyocyte apoptosis via upregulating SIRT1 and miR-22 might be a new target for treating Dox-induced cardiotoxicity.

We have investigated the low-lying energy spectrum and electromagnetic transition strengths in even–even 76Se using the proton–neutron interacting boson model (IBM-2). The theoretical calculation for the energy levels and E2 and M1 transition strengths is in good agreement with the experimental data. Specifically, the excitation energy and E2 transition of 0 2 + state, which is intimately associated with shape coexistence, can be accurately reproduced. The analysis on low-lying states and the key structure indicators R 1, R 2, R 3 and R 4 and M1 transitions indicates that there is a coexistence between spherical shape and γ-soft shape in 76Se.

Based on the neutron and proton degrees of freedom, the low-lying energy levels, the $E2$, $M1$ and $E0$ transition strengths of nucleus $^{124}$Te have been calculated by the neutron-proton interacting boson model. The calculated results are quite consistent with the experimental data. By comparing the key observables of states at the critical point of $\textrm{U}_{\pi \nu}(5)$--$\textrm{O}_{\pi \nu}(6)$ transition with experimental data and calculated results, we show that the $^{124}$Te is a possible nucleus at the critical point of the second order phase transition from vibration to unstable rotation and such a critical point contains somewhat triaxial rotation. The 0$^+_2$ state of $^{124}$Te can be interpreted as the lowest state of the first excited family of intrinsic levels in the critical point symmetry., Comment: 19 pages, 1 figure, 3 tables

Healable, electrically conductive materials are highly desirable and valuable for the development of various modern electronics. But the preparation of a material combining good mechanical elasticity, functional properties, and intrinsic self-healing ability remains a great challenge. Here, we design composites by connecting a polymer network and single-walled carbon nanotubes (SWCNTs) through host-guest interactions. The resulting materials show bulk electrical conductivity, proximity sensitivity, humidity sensitivity and are able to self-heal without external stimulus under ambient conditions rapidly. Furthermore, they also possess elasticity comparable to commercial rubbers.

A self-healable conductive composite is developed by combining the small molecules and nanotubes through host-guest interactions. This material shows uniform conductivity, microwave absorption and humidity sensing properties, and can be rapidly healed to over 90% electrical and mechanical properties with the aid of water multiple times. In addition, the produced material is also remouldable and recyclable.

Humanity has an urgent need to develop more degradable materials for solving environmental pollution. In this study, through host–guest interactions between fatty acids-modified β-cyclodextrin (Em-βCD) and polyethylenimine (PEI) oligomer-grafted ferrocene (PEI-Fc), we designed and prepared a supramolecular polymer (PEI-Fc/Em-βCD complex), which showed polymeric properties and was able to be used as a cushioning material due to its good compressibility. Compared with conventional polymers, a remarkable advantage of the PEI-Fc/Em-βCD complex is that it can be dismantled into small molecules and rebuilt easily by controlling the dissociation or reformation of βCD-Fc inclusion complexes. Furthermore, the material also exhibited good self-healing properties.

We have investigated the structure evolution of the 124–134Xe isotopic chain in the framework of the proton-neutron interacting model IBM2. The positive parity spectra of the ground state, quasi-β and quasi-γ bands are reproduced well. The staggering in 124–130Xe are almost completely removed and the γ band agree well with the experiment data, even for the high-spin quasi-γ states. The key quantities of the collective structure evolution, including level energies, the B(E2) transition branching ratios, and the M1 excitations to 1+1 mixer-symmetry states are analyzed by comparing with the experimental data. The parameters for representation of the Oπν(6) and SU*πν(3) features in isotopes are examined. Both experimental data and theoretical results show that the shape phase transition of 124–134Xe isotopic chain is from the SU*πν(3) (triaxial rotation) to the Uπν(5) (vibration motion) with a considerable constituent of the Oπν(6) symmetry (γ-unstable rotation), where the shape phase transition rapidly takes place between the neutron number N = 76 and N = 78.

The WuSu Bridge of HeiXiaZi Island is a hybrid girder cable-stayed bridge with one pylons and single cable plane. Based on the similarity principle, a 1:3 reduced scale test model of steel-concrete joint section was designed to study the load transfer mechanism and verify the rationality. The test model was loaded according to the serviceability limit state, and the stress distribution of control sections and main members were obtained. The finite element analysis on the test model was carried out and the load transfer mechanism was studied by the way of combining the test results and the FEA results. As shown in the results, the load from steel is smoothly delivered to concrete through steel-concrete joint section, and the load distribution of the components of steel-concrete joint section is rational. It is proved that the steel-concrete composite joint section is reasonably designed.

Chromatography has found an increasingly wide utilization in scientific and technological fields, even in some cases, has become indispensable methods for analysis and separation. Compared with its application, some common queries in chromatography still lack for good theoretical explanations, for instance, the action of flow rate of mobile phase on symmetry of peak. As is familiar to people, an increase in flow rate of mobile phase always causes theoretical plate number to decrease under normal conditions. At the same time, maybe the symmetry of chromatographic peak obviously increases, on the contrary. This result is self-contradictory. Why does the theoretical plate number not increase under the condition? Utilizing our prior paper on five plate numbers in chromatography, this paper points out why theoretical plate number decreases with an increase in symmetry of peak when flow rate of mobile phase increases. Based upon gas-solid chromatography results, the relation between flow rate of mobile phase and frequency of partition of solute, and the relation between flow rate and plate number are deduced. From the angle of theoretical model, this paper discusses the relation between solute partition in static mobile phase such as partition between two phases in plate theory and solute partition in flowing mobile phase such as Martin-Synge partition in slip mechanism, and their characteristics.

The five plate numbers were peak plate number (q’), slip-mechanism plate number (q), theoretical plate number (n0), real plate number (n) and plate-model plate number (q0). Slip mechanism was introduced into plate model and then a new equation of elution curve was deduced. The relational expression of five plate numbers was deduced through the new equation. Peak plate number and slip-mechanism plate number were new plate numbers derived from slip mechanism, and the physical pictures of them was discussed. Peak plate number would be regarded as an asymmetry index of peak, as column plate number is regarded as an efficiency index of column.

Durability of C100 concrete in Shenyang WAN XIN Hotel engineering including long-term mechanical properties, dynamic modulus of elasticity, and chloride ion resistance was tested and analyzed. Test results appeared that C100 concrete had very good density and extremely good durability. Simultaneously we suggest improving the evaluation method to test the durability of super-high strength concrete in order to enhance the evaluation level effectively. It will provide one according of durability to apply super-high strength concrete.

This paper investigated a new type of admixture which can be used to enhance the resistance of concrete surface to deicing salt deteriorating. Physical and mechanical properties of concrete incorporating this salt-scaling resistant admixture were measured. Practical application on site has proved that this admixture is effective for concrete to resist salt-scaling action.

We synthesized eight tanshinone anhydrides and the alcoholytic derivatives through a mild oxygen-insertion under Pd/C catalytic hydrogenation conditions. The suppressive effects of the anhydrides on the oxidized low-density lipoprotein (oxLDL) uptake and the oxLDL-induced macrophage-derived foam cell formation were studied. Our results revealed that both anhydrides 1a and 2a could significantly suppress the oxLDL uptake in macrophages and the foam cell formation at micromolar level, which might be partially attributed to their inhibition of oxLDL-induced LOX-1 expression in macrophages.

A series of diacyltanshinol derivatives were synthesized by esterifying the corresponding o-hydroquinones of tanshinones. The suppressive effects of the synthesized compounds on oxidized low-density lipoprotein (oxLDL) uptake and oxLDL-induced macrophage-derived foam cell formation were evaluated. Our results indicated that the nicotinate derivatives 1a and 2a, modified from tanshinone IIA and cryptotanshinone, showed stronger suppressive activity on oxLDL uptake and the resultant foam cell formation relative to tanshinone IIA. Western Blot analysis indicated that derivatives 1a and 2a could dose-dependently inhibit the expression of oxLDL-induced LOX-1, implying that the suppressive effects of 1a and 2a on oxLDL uptake and foam cell formation could be at least partially attributed to the inhibition of LOX-1 expression in macrophages.

An oxygen-insertion reaction that transforms an o-quinone and a conjugated α-diketone substrate into an anhydride product or derivative under catalytic hydrogenation conditions is reported. The experiments and computations indicate that the oxygen insertion proceeds via a radical mechanism mediated by an acetoxyl radical.

The properties of the low-lying states and the shape coexistence in 98Sr are investigated within the framework of the proton—neutron interacting boson model (IBM2). By considering the relative energy of the d proton boson to be different from that of the neutron boson, it is found that the calculated energy levels and the B(E2) transition strengths agree with the experimental data perfectly. Particularly, the second 0+ state, which is associated with the shape coexistence phenomenon and has the lowest energy E(02 +) among all known even—even nuclei, is reproduced very well. The behavior of the calculated quadrupole shape invariants is consistent with the experimental results.

In the title molecule, C18H11FN2O4, the fused four- ring system is essentially planar, with an r.m.s. deviation of 0.032 Å. In the crystal, molecules are connected by π–π stacking interactions [centroid–centroid distances = 3.5684 (9) and 3.8247 (9) Å] into chains along [100].

A description on the even-even Barium isotopes for to and in the framework of neutron-proton interacting boson model is carried out. By introducing the quadrupole interactions among like bosons into the Hamiltonian, the staggering phenomenon in the quasi- bands is reproduced pretty well. The physical mechanism behind the improvement is discussed.

To investigate the effect of ginsenoside (GSS) in regulating level of sex hormone receptors in human liver cell line HL-7702.The growth of HL-7702 were detected by MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay for choosing the available concentration of GSS; and the effect of GSS on sex hormone receptors in HL-7702 cells were detected by immuno-histochemistry, Western blot and RT-PCR.GSS significantly enhance the protein and mRNA expressions of estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR) in HL7702 cell in a dose-dependent manner, the levels of expressions in the GSS treated group were higher than those in the solvent control group respectively (P0.05).GSS can up-regulate the protein and mRNA expressions of sex hormone receptors in HL-7702.

Saikosaponin-d (SSd), a saponin derivative with a similar structure to estradiol, was extracted from Bupleurum falcatum L. (Umbelliferae). It was found that SSd stimulated the proliferation of MCF-7 cells by using MCF-7 cell proliferation assay. Cell-cycle analysis revealed that the proliferation-stimulating effect was associated with a marked increase in the number of MCF-7 cells in S phase. These actions of SSd were dose-dependent at doses ranging from 10nM to 10 microM and could be significantly inhibited by the specific estrogen receptor (ER) antagonist ICI-182780. Co-incubation of MCF-7 cells with 1 microM of ER antagonist ICI-182780 abolished the inductive effects of SSd on estrogen response element (ERE)-luciferase activity, suggesting that the estrogenic effects of SSd were mediated through the estrogen receptors. To evaluate the relative involvement of estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) in mediating the actions of SSd, ER-negative human cervical carcinoma (HeLa) cells were cotransfected with the ERE-luciferase reporter construct and either ERalpha or ERbeta construct. The results showed that SSd could activate ERE-luciferase activity via the ERalpha-mediated pathway in a dose-dependent manner (10 nM to 10 microM); whereas, the activation of ERbeta-mediated ERE-luciferase activity by SSd only occurred at a high concentration (10 microM). Furthermore, the ERalpha protein and mRNA levels were increased by treatment with SSd within 24h. These data support our hypothesis that SSd acts as a weak phytoestrogen. Presumably, the estrogenic effect of SSd is mediated by the estrogen receptor.

The characteristics of the lowest mixed-symmetry states 2+ms and 1+ms for 132Xe, 134Ba and 136Ce in the even-even N = 78 isotones are investigated within the framework of the IBM2 model. The lowest mixed-symmetry state 2+ms levels for both a single isolated state in 132Xe and 136Ce and a fragmented state in 134Ba are reproduced by the predictions. The agreement between the IBM2 calculation and the experimental values is good for the B(E2) and B(M1) transition probabilities both quantitatively and qualitatively. The predicted summed B(M1) strength follows the experimental data, remaining nearly constant as a function of proton number along the chain of the N = 78 isotones.

We investigate the properties of the low-lying states and the relevant shape dynamics of 98Mo within the framework of the proton-neutron interacting boson model (IBM2). By considering the relative energy of the d proton boson to be different from that of the neutron bosons, the low-lying levels and the key observable B(E2) transition branching ratios are calculated. The characteristic feature of the energy spectrum and the most crucial available structure indicator indicate that the substantial mixing between the spherical-vibrational and γ-unstable shapes in 98Mo. The calculation results of the overall deformation in 98Mo are almost the same for both the ground and the first excited 0+ states, showing a weak deformation. While the triaxiality parameter indicates that the mostly triaxial shape with some oblate for the ground state, and the triaxial shape with some prolate for the excited 0+2 state, being equilibrium shapes of spherical-vibrational and γ-unstable in 98Mo.

To study a new method of venous flap that is improved on its persistence and quality.New Zealand white rabbits were subdivided randomly into 4 groups. All rabbits were operated by harvesting a flap from the latero-abdominal wall and then sutured it in the original position. Group A: the superficial epigastric vein in the pedicle was left open (only one inflow vein remained). Group B: the pedicle vein of the proximal and distant end were left open (keeping an inflow vein and a principal out). Group C: the pedicle vein and a tributary vein were left open (keeping an inflow vein and a tributary outflow vein). Group D: the pedicle vein and two tributary veins were left open (keeping an inflow vein and two tributary outflow veins). Survival rate, MDA of the tissue, histology and ultra-microstructure were examined.Survival rate of A, B, C, D were improved in order. Statistic difference is significant (P0.05) between group and group other than C and D. The content of MDA was heightened with statistically significant differences (ABCD) among the four groups 8 hours postoperatively, but fell back to the normal level in group D and C and kept a high level in group A and B at 72 hour postoperatively. Histology and ultra-microstructure exam showed that degeneration of collagen fiber and karyopyknosis of cell is more obvious in Group A and Group B than Group C and Group D.The higher survival rate of venous flap is possible by designing the more reasonable venous flap outputs pedicles which can alleviate the high tension dropsy and maintain the valid equilibrium of pour with flow in the venous flap.

We describe the properties of low-lying states of 102Ru within the framework of the proton-neutron interacting model IBM2. The theoretical predictions of the ground state, quasi-γ and quasi-β bands, and the ratios of the B(E2) transition strengths are reproduced very well. The structural properties of 102Ru are identified in the parameters space of the interacting boson model (IBM2). The characteristic feature of the energy spectrum structure exhibits that 102Ru is very close to the critical point of Uπv(5)—Oπv(6) transition and towards Uπv(5) symmetry. The key sensitive quantities of the B(E2) branching ratio clearly indicate that 102Ru is a primary Oπv (6) symmetry, while with a somewhat Uπv (5) symmetry. It is possible that the shape coexistence persists in 102Ru, whereas the evident fingerprint of the shape coexistence has not been observed.

The chiral doublet bands in 135Nd and 136Nd are investigated systematically within the supersymmetry scheme including many-body interactions and possessing the SO(5)(or SU(5)) symmetry on the rotational symmetry. Quantitatively good results of the energy spectra, the energy staggering parameter as a function of the spin and the spin assignment are obtained. The calculation shows that the stronger competition between the pairing and anti-pairing effects exists in these chiral doublet bands and the SU(3) symmetry breaking more seriously exists in the stable chiral structure.