Search

Your search keyword '"Da Silveira, William A. [0000-0001-6370-2884]"' showing total 9 results
Start Over Author "Da Silveira, William A. [0000-0001-6370-2884]"
9 results on '"Da Silveira, William A. [0000-0001-6370-2884]"'

1. Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research

Author

European Space Agency, NASA Astrobiology Institute (US), University of Nottingham, Medical Research Council (UK), Comunidad de Madrid, Manzano, Aranzazu [0000-0002-0150-0803], Weging, Silvio [0000-0002-8484-4352], Bezdan, Daniela [0000-0002-1203-8239], Cahill, Thomas [0000-0003-3607-6069], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Cope, Henry [0000-0002-4984-0567], Deane, Colleen S. [0000-0002-2281-6479], Etheridge,Timothy [0000-0002-3588-8711], Giacomello, Stefania [0000-0003-0738-1574], Hardiman, Gary [0000-0003-4558-0400], Leys, Natalie [0000-0002-4556-5211], Madrigal, Pedro [0000-0003-1959-8199], Mastroleo, Felice [0000-0002-9815-8038], Medina, F. Javier [0000-0002-0866-7710], Mieczkowski, Jakub [0000-0002-2091-012X], Fernández-Rojo, Manuel A. [0000-0002-2240-1951], Siew, Keith [0000-0002-6502-5095], Szewczyk, Nathaniel [0000-0003-4425-9746], Walsh, Stephen B. [0000-0002-8693-1353], Da Silveira, William A. [0000-0001-6370-2884], Herranz, Raúl [0000-0002-0246-9449], Manzano, Aranzazu, Weging, Silvio, Bezdan, Daniela, Borg, Joseph, Cahill, Thomas, Carnero-Díaz, Eugénie, Cope, Henry, Deane, Colleen S., Etheridge,Timothy, Giacomello, Stefania, Hardiman, Gary, Leys, Natalie, Madrigal, Pedro, Mastroleo, Felice, Medina, F. Javier, Mieczkowski, Jakub, Fernández-Rojo, Manuel A., Siew, Keith, Szewczyk, Nathaniel, Walsh, Stephen B., Da Silveira, William A., Herranz, Raúl, European Space Agency, NASA Astrobiology Institute (US), University of Nottingham, Medical Research Council (UK), Comunidad de Madrid, Manzano, Aranzazu [0000-0002-0150-0803], Weging, Silvio [0000-0002-8484-4352], Bezdan, Daniela [0000-0002-1203-8239], Cahill, Thomas [0000-0003-3607-6069], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Cope, Henry [0000-0002-4984-0567], Deane, Colleen S. [0000-0002-2281-6479], Etheridge,Timothy [0000-0002-3588-8711], Giacomello, Stefania [0000-0003-0738-1574], Hardiman, Gary [0000-0003-4558-0400], Leys, Natalie [0000-0002-4556-5211], Madrigal, Pedro [0000-0003-1959-8199], Mastroleo, Felice [0000-0002-9815-8038], Medina, F. Javier [0000-0002-0866-7710], Mieczkowski, Jakub [0000-0002-2091-012X], Fernández-Rojo, Manuel A. [0000-0002-2240-1951], Siew, Keith [0000-0002-6502-5095], Szewczyk, Nathaniel [0000-0003-4425-9746], Walsh, Stephen B. [0000-0002-8693-1353], Da Silveira, William A. [0000-0001-6370-2884], Herranz, Raúl [0000-0002-0246-9449], Manzano, Aranzazu, Weging, Silvio, Bezdan, Daniela, Borg, Joseph, Cahill, Thomas, Carnero-Díaz, Eugénie, Cope, Henry, Deane, Colleen S., Etheridge,Timothy, Giacomello, Stefania, Hardiman, Gary, Leys, Natalie, Madrigal, Pedro, Mastroleo, Felice, Medina, F. Javier, Mieczkowski, Jakub, Fernández-Rojo, Manuel A., Siew, Keith, Szewczyk, Nathaniel, Walsh, Stephen B., Da Silveira, William A., and Herranz, Raúl

Abstract

Following on from the NASA twins’ study there has been a tremendous interest in the use of omics techniques in spaceflight. The individual space agency’s, NASA’s GeneLab, JAXA´s ibSLS and ESA-funded Space Omics Topical Team and the International Standards for Space Omics Processing (ISSOP) group have established several initiatives to support this growth. Here, we present recommendations from the Space Omics Topical Team to promote standard application of space omics in Europe. We focus on four main themes: i) continued participation in and co-ordination with international omics endeavours; ii) strengthening of the European space omics infrastructure including workforce and facilities; iii) capitalizing on the emerging opportunities in the commercial space sector, and iv) capitalizing on the emerging opportunities in human subjects research.

Published
2023

2. Building the Space Omics Topical Team to boost European space researchers’ role in the international consortia redefining spaceflight-generated datasets

Author

Herranz, Raúl [0000-0002-0246-9449], Da Silveira, William A. [0000-0001-6370-2884], Bezdan, Daniela [0000-0002-1203-8239], Giacomello, Stefania [0000-0003-0738-1574], Szewczyk, Nathaniel [0000-0003-4425-9746], Herranz, Raúl, Da Silveira, William A., Bezdan, Daniela, Giacomello, Stefania, Szewczyk, Nathaniel, Herranz, Raúl [0000-0002-0246-9449], Da Silveira, William A. [0000-0001-6370-2884], Bezdan, Daniela [0000-0002-1203-8239], Giacomello, Stefania [0000-0003-0738-1574], Szewczyk, Nathaniel [0000-0003-4425-9746], Herranz, Raúl, Da Silveira, William A., Bezdan, Daniela, Giacomello, Stefania, and Szewczyk, Nathaniel

Abstract

In a broadening and more competitive space exploration landscape, playing at scale is necessary to obtain results. European researchers share their lessons learned on growing a research program where omics techniques can feed new knowledge, both fundamental and practical, for space exploration. Sending people to new space destinations will require interdisciplinary research centered around omics and personalized medicine, with added constraints of low-gravity and high-radiation environments.

Published
2022

3. Space omics research in Europe: contributions, geographical distribution and ESA member state funding schemes

Author

European Space Agency, National Aeronautics and Space Administration (US), Medical Research Council (UK), Comunidad de Madrid, Ministerio de Ciencia e Innovación (España), Swedish Research Council, Centre National D'Etudes Spatiales (France), Wellcome Trust, Deane, Colleen S. [0000-0002-2281-6479], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Etheridge,Timothy [0000-0002-3588-8711], Hardiman, Gary [0000-0003-4558-0400], Leys, Natalie [0000-0002-4556-5211], Madrigal, Pedro [0000-0003-1959-8199], Manzano, Aranzazu [0000-0002-0150-0803], Mastroleo, Felice [0000-0002-9815-8038], Medina, F. Javier [0000-0002-0866-7710], Fernández-Rojo, Manuel A. [0000-0002-2240-1951], Siew, Keith [0000-0002-6502-5095], Szewczyk, Nathaniel [0000-0003-4425-9746], Villacampa, Alicia [0000-0002-7398-8545], Walsh, Stephen B. [0000-0002-8693-1353], Weging, Silvio [0000-0002-8484-4352], Bezdan, Daniela [0000-0002-1203-8239], Giacomello, Stefania [0000-0003-0738-1574], Da Silveira, William A. [0000-0001-6370-2884], Herranz, Raúl [0000-0002-0246-9449], Deane, Colleen S., Borg, Joseph, Cahill, Thomas, Carnero-Díaz, Eugénie, Etheridge,Timothy, Hardiman, Gary, Leys, Natalie, Madrigal, Pedro, Manzano, Aranzazu, Mastroleo, Felice, Medina, F. Javier, Fernández-Rojo, Manuel A., Siew, Keith, Szewczyk, Nathaniel, Villacampa, Alicia, Walsh, Stephen B., Weging, Silvio, Bezdan, Daniela, Giacomello, Stefania, Da Silveira, William A., Herranz, Raúl, European Space Agency, National Aeronautics and Space Administration (US), Medical Research Council (UK), Comunidad de Madrid, Ministerio de Ciencia e Innovación (España), Swedish Research Council, Centre National D'Etudes Spatiales (France), Wellcome Trust, Deane, Colleen S. [0000-0002-2281-6479], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Etheridge,Timothy [0000-0002-3588-8711], Hardiman, Gary [0000-0003-4558-0400], Leys, Natalie [0000-0002-4556-5211], Madrigal, Pedro [0000-0003-1959-8199], Manzano, Aranzazu [0000-0002-0150-0803], Mastroleo, Felice [0000-0002-9815-8038], Medina, F. Javier [0000-0002-0866-7710], Fernández-Rojo, Manuel A. [0000-0002-2240-1951], Siew, Keith [0000-0002-6502-5095], Szewczyk, Nathaniel [0000-0003-4425-9746], Villacampa, Alicia [0000-0002-7398-8545], Walsh, Stephen B. [0000-0002-8693-1353], Weging, Silvio [0000-0002-8484-4352], Bezdan, Daniela [0000-0002-1203-8239], Giacomello, Stefania [0000-0003-0738-1574], Da Silveira, William A. [0000-0001-6370-2884], Herranz, Raúl [0000-0002-0246-9449], Deane, Colleen S., Borg, Joseph, Cahill, Thomas, Carnero-Díaz, Eugénie, Etheridge,Timothy, Hardiman, Gary, Leys, Natalie, Madrigal, Pedro, Manzano, Aranzazu, Mastroleo, Felice, Medina, F. Javier, Fernández-Rojo, Manuel A., Siew, Keith, Szewczyk, Nathaniel, Villacampa, Alicia, Walsh, Stephen B., Weging, Silvio, Bezdan, Daniela, Giacomello, Stefania, Da Silveira, William A., and Herranz, Raúl

Abstract

The European research community, via European Space Agency (ESA) spaceflight opportunities, has significantly contributed towards our current understanding of spaceflight biology. Recent molecular biology experiments include “omic” analysis, which provides a holistic and systems level understanding of the mechanisms underlying phenotypic adaptation. Despite vast interest in, and the immense quantity of biological information gained from space omics research, the knowledge of ESA-related space omics works as a collective remains poorly defined due to the recent exponential application of omics approaches in space and the limited search capabilities of pre-existing records. Thus, a review of such contributions is necessary to clarify and promote the development of space omics among ESA and ESA state members. To address this gap, in this review we: i) identified and summarised omics works led by European researchers, ii) geographically described these omics works, and iii) highlighted potential caveats in complex funding scenarios among ESA member states.

Published
2022

4. Mammalian and invertebrate models as complementary tools for gaining mechanistic insight on muscle responses to spaceflight

Author

University of Nottingham, Agencia Estatal de Investigación (España), NASA Astrobiology Institute (US), Cope, Henry [0000-0002-4984-0567], Bass, Joseph J. [0000-0002-8236-681X], Overbey, Eliah G. [0000-0002-2866-8294], Gilbert, Rachel [0000-0002-1380-8012], Da Silveira, William A. [0000-0001-6370-2884], Paul, Amber M. [0000-0002-1657-3618], Mishra, Tejaswini [0000-0001-9931-1260], Herranz, Raúl [0000-0002-0246-9449], Reinsch, Sigrid [0000-0002-6484-7521], Costes, Sylvain V. [0000-0002-8542-2389], Hardiman, Gary [0000-0003-4558-0400], Szewczyk, Nathaniel [0000-0003-4425-9746], Tahimic, Candice G. T. [0000-0001-5862-2652], Cahill, Thomas, Cope, Henry, Bass, Joseph J., Overbey, Eliah G., Gilbert, Rachel, Da Silveira, William A., Paul, Amber M., Mishra, Tejaswini, Herranz, Raúl, Reinsch, Sigrid, Costes, Sylvain V., Hardiman, Gary, Szewczyk, Nathaniel, Tahimic, Candice G. T., University of Nottingham, Agencia Estatal de Investigación (España), NASA Astrobiology Institute (US), Cope, Henry [0000-0002-4984-0567], Bass, Joseph J. [0000-0002-8236-681X], Overbey, Eliah G. [0000-0002-2866-8294], Gilbert, Rachel [0000-0002-1380-8012], Da Silveira, William A. [0000-0001-6370-2884], Paul, Amber M. [0000-0002-1657-3618], Mishra, Tejaswini [0000-0001-9931-1260], Herranz, Raúl [0000-0002-0246-9449], Reinsch, Sigrid [0000-0002-6484-7521], Costes, Sylvain V. [0000-0002-8542-2389], Hardiman, Gary [0000-0003-4558-0400], Szewczyk, Nathaniel [0000-0003-4425-9746], Tahimic, Candice G. T. [0000-0001-5862-2652], Cahill, Thomas, Cope, Henry, Bass, Joseph J., Overbey, Eliah G., Gilbert, Rachel, Da Silveira, William A., Paul, Amber M., Mishra, Tejaswini, Herranz, Raúl, Reinsch, Sigrid, Costes, Sylvain V., Hardiman, Gary, Szewczyk, Nathaniel, and Tahimic, Candice G. T.

Abstract

Bioinformatics approaches have proven useful in understanding biological responses to spaceflight. Spaceflight experiments remain resource intensive and rare. One outstanding issue is how to maximize scientific output from a limited number of omics datasets from traditional animal models including nematodes, fruitfly, and rodents. The utility of omics data from invertebrate models in anticipating mammalian responses to spaceflight has not been fully explored. Hence, we performed comparative analyses of transcriptomes of soleus and extensor digitorum longus (EDL) in mice that underwent 37 days of spaceflight. Results indicate shared stress responses and altered circadian rhythm. EDL showed more robust growth signals and Pde2a downregulation, possibly underlying its resistance to atrophy versus soleus. Spaceflight and hindlimb unloading mice shared differential regulation of proliferation, circadian, and neuronal signaling. Shared gene regulation in muscles of humans on bedrest and space flown rodents suggest targets for mitigating muscle atrophy in space and on Earth. Spaceflight responses of C. elegans were more similar to EDL. Discrete life stages of D. melanogaster have distinct utility in anticipating EDL and soleus responses. In summary, spaceflight leads to shared and discrete molecular responses between muscle types and invertebrate models may augment mechanistic knowledge gained from rodent spaceflight and ground-based studies.

Published
2021

5. Revamping Space-omics in Europe

Author

National Aeronautics and Space Administration (US), Madrigal, Pedro [0000-0003-1959-8199], Manzano, Aranzazu [0000-0002-0150-0803], Deane, Colleen S. [0000-0002-2281-6479], Bezdan, Daniela [0000-0002-1203-8239], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Medina, F. Javier [0000-0002-0866-7710], Hardiman, Gary [0000-0003-4558-0400], Grosse, Ivo [0000-0001-5318-4825], Szewczyk, Nathaniel [0000-0003-4425-9746], Weging, Silvio [0000-0002-8484-4352], Giacomello, Stefania [0000-0003-0738-1574], Harridge, Stephen D.R. [0000-0002-8203-0769], Da Silveira, William A. [0000-0001-6370-2884], Herranz, Raúl [0000-0002-0246-9449], Madrigal, Pedro, Gabel, Alexander, Villacampa, Alicia, Manzano, Aranzazu, Deane, Colleen S., Bezdan, Daniela, Carnero-Díaz, Eugénie, Medina, F. Javier, Hardiman, Gary, Grosse, Ivo, Szewczyk, Nathaniel, Weging, Silvio, Giacomello, Stefania, Harridge, Stephen D.R., Morris-Paterson, Tessa, Cahill, Thomas, Da Silveira, William A., Herranz, Raúl, National Aeronautics and Space Administration (US), Madrigal, Pedro [0000-0003-1959-8199], Manzano, Aranzazu [0000-0002-0150-0803], Deane, Colleen S. [0000-0002-2281-6479], Bezdan, Daniela [0000-0002-1203-8239], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Medina, F. Javier [0000-0002-0866-7710], Hardiman, Gary [0000-0003-4558-0400], Grosse, Ivo [0000-0001-5318-4825], Szewczyk, Nathaniel [0000-0003-4425-9746], Weging, Silvio [0000-0002-8484-4352], Giacomello, Stefania [0000-0003-0738-1574], Harridge, Stephen D.R. [0000-0002-8203-0769], Da Silveira, William A. [0000-0001-6370-2884], Herranz, Raúl [0000-0002-0246-9449], Madrigal, Pedro, Gabel, Alexander, Villacampa, Alicia, Manzano, Aranzazu, Deane, Colleen S., Bezdan, Daniela, Carnero-Díaz, Eugénie, Medina, F. Javier, Hardiman, Gary, Grosse, Ivo, Szewczyk, Nathaniel, Weging, Silvio, Giacomello, Stefania, Harridge, Stephen D.R., Morris-Paterson, Tessa, Cahill, Thomas, Da Silveira, William A., and Herranz, Raúl

Published
2020

6. Space omics research in Europe: contributions, geographical distribution and ESA member state funding schemes

Author

Colleen S. Deane, Willian A. da Silveira, Raúl Herranz, Joseph Borg, Thomas Cahill, Eugénie Carnero-Diaz, Timothy Etheridge, Gary Hardiman, Natalie Leys, Pedro Madrigal, Aránzazu Manzano, Felice Mastroleo, F. Javier Medina, Manuel A. Fernandez-Rojo, Keith Siew, Nathaniel J. Szewczyk, Alicia Villacampa, Stephen B. Walsh, Silvio Weging, Daniela Bezdan, Stefania Giacomello, European Space Agency, National Aeronautics and Space Administration (US), Medical Research Council (UK), Comunidad de Madrid, Ministerio de Ciencia e Innovación (España), Swedish Research Council, Centre National D'Etudes Spatiales (France), Wellcome Trust, Deane, Colleen S. [0000-0002-2281-6479], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Etheridge,Timothy [0000-0002-3588-8711], Hardiman, Gary [0000-0003-4558-0400], Leys, Natalie [0000-0002-4556-5211], Madrigal, Pedro [0000-0003-1959-8199], Manzano, Aranzazu [0000-0002-0150-0803], Mastroleo, Felice [0000-0002-9815-8038], Medina, F. Javier [0000-0002-0866-7710], Fernández-Rojo, Manuel A. [0000-0002-2240-1951], Siew, Keith [0000-0002-6502-5095], Szewczyk, Nathaniel [0000-0003-4425-9746], Villacampa, Alicia [0000-0002-7398-8545], Walsh, Stephen B. [0000-0002-8693-1353], Weging, Silvio [0000-0002-8484-4352], Bezdan, Daniela [0000-0002-1203-8239], Giacomello, Stefania [0000-0003-0738-1574], Da Silveira, William A. [0000-0001-6370-2884], Herranz, Raúl [0000-0002-0246-9449], Deane, Colleen S., Carnero-Díaz, Eugénie, Etheridge,Timothy, Hardiman, Gary, Leys, Natalie, Madrigal, Pedro, Manzano, Aranzazu, Mastroleo, Felice, Medina, F. Javier, Fernández-Rojo, Manuel A., Siew, Keith, Szewczyk, Nathaniel, Villacampa, Alicia, Walsh, Stephen B., Weging, Silvio, Bezdan, Daniela, Giacomello, Stefania, Da Silveira, William A., Herranz, Raúl, and Space Omics Topical Team

Subjects
Space flight, Space sciences -- International cooperation, Multidisciplinary, Outer space -- Exploration -- Europe, Space sciences, Omics, Space medicine, Astrobiology, General, European Space Agency, International Space Station, Space biology -- Research
Abstract

18 p.-3 fig.-1 graph. abst., The European research community, via European Space Agency (ESA) spaceflight opportunities, has significantly contributed towards our current understanding of spaceflight biology. Recent molecular biology experiments include “omic” analysis, which provides a holistic and systems level understanding of the mechanisms underlying phenotypic adaptation. Despite vast interest in, and the immense quantity of biological information gained from space omics research, the knowledge of ESA-related space omics works as a collective remains poorly defined due to the recent exponential application of omics approaches in space and the limited search capabilities of pre-existing records. Thus, a review of such contributions is necessary to clarify and promote the development of space omics among ESA and ESA state members. To address this gap, in this review we: i) identified and summarised omics works led by European researchers, ii) geographically described these omics works, and iii) highlighted potential caveats in complex funding scenarios among ESA member states., All listed authors are members of the ESA Space Omics Topical Team, funded by the ESA grant/contract 4000131202/20/NL/PG/pt “Space Omics: Towards an integrated ESA/NASA –omics database for spaceflight and ground facilities experiments” awarded to RH, which was the main funding source for this work. Individual authors also acknowledge support from: the Medical Research Council part of a Skills Development Fellowship [grant number MR/T026014/1] awarded to CSD; the Spanish CAM TALENTO program project 2020-5A_BIO-19724 to MAFR; the Spanish Plan Estatal de Investigación Científica y Desarrollo Tecnológico Grant RTI2018-099309-B-I00 to FJM, the Swedish Research Council VR grant 2020-04864 to SG and the French Centre National d'Etudes Spatiales grant DAR 2020-4800001004, 2021-4800001117 to ECD. This research was also funded in part by the Wellcome Trust [110182/Z/15/Z] to KS.

Published
2022
Full Text
View/download PDF

7. Building the Space Omics Topical Team to boost European space researchers’ role in the international consortia redefining spaceflight-generated datasets

Author

Raúl Herranz, Willian da Silveira, Daniela Bezdan, Stefania Giacomello, Nathaniel Szewczyk, Herranz, Raúl [0000-0002-0246-9449], Da Silveira, William A. [0000-0001-6370-2884], Bezdan, Daniela [0000-0002-1203-8239], Giacomello, Stefania [0000-0003-0738-1574], Szewczyk, Nathaniel [0000-0003-4425-9746], Herranz, Raúl, Da Silveira, William A., Bezdan, Daniela, Giacomello, Stefania, and Szewczyk, Nathaniel

Subjects
Multidisciplinary
Abstract

4 p., In a broadening and more competitive space exploration landscape, playing at scale is necessary to obtain results. European researchers share their lessons learned on growing a research program where omics techniques can feed new knowledge, both fundamental and practical, for space exploration. Sending people to new space destinations will require interdisciplinary research centered around omics and personalized medicine, with added constraints of low-gravity and high-radiation environments.

Published
2022

8. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight

Author

Henry Cope, Candice Tahimic, Rachel Gilbert, Joseph J. Bass, Sigrid Reinsch, Nathaniel J. Szewczyk, Sylvain V. Costes, Eliah G. Overbey, Thomas J. Cahill, Raúl Herranz, Amber M. Paul, Willian A. da Silveira, Gary Hardiman, Tejaswini Mishra, University of Nottingham, Agencia Estatal de Investigación (España), NASA Astrobiology Institute (US), Cope, Henry [0000-0002-4984-0567], Bass, Joseph J. [0000-0002-8236-681X], Overbey, Eliah G. [0000-0002-2866-8294], Gilbert, Rachel [0000-0002-1380-8012], Da Silveira, William A. [0000-0001-6370-2884], Paul, Amber M. [0000-0002-1657-3618], Mishra, Tejaswini [0000-0001-9931-1260], Herranz, Raúl [0000-0002-0246-9449], Reinsch, Sigrid [0000-0002-6484-7521], Costes, Sylvain V. [0000-0002-8542-2389], Hardiman, Gary [0000-0003-4558-0400], Szewczyk, Nathaniel [0000-0003-4425-9746], Tahimic, Candice G. T. [0000-0001-5862-2652], Cope, Henry, Bass, Joseph J., Overbey, Eliah G., Gilbert, Rachel, Da Silveira, William A., Paul, Amber M., Mishra, Tejaswini, Herranz, Raúl, Reinsch, Sigrid, Costes, Sylvain V., Hardiman, Gary, Szewczyk, Nathaniel, and Tahimic, Candice G. T.

Subjects
Extraterrestrial Environment, Hindlimb unloading, muscle, Gene Expression, law.invention, Transcriptome, Neuronal signaling, Mice, transcriptomics, law, Databases, Genetic, Melanogaster, Biology (General), Spectroscopy, Regulation of gene expression, biology, musculoskeletal, neural, and ocular physiology, General Medicine, musculoskeletal system, Muscle atrophy, Circadian Rhythm, Animal models, Computer Science Applications, Muscular Atrophy, Chemistry, Drosophila melanogaster, Hindlimb Suspension, Models, Animal, Muscle, medicine.symptom, QH301-705.5, Spaceflight, Article, Catalysis, Cross-species comparison, Inorganic Chemistry, spaceflight, Stress, Physiological, medicine, Animals, Physical and Theoretical Chemistry, Caenorhabditis elegans, Muscle, Skeletal, Transcriptomics, Molecular Biology, QD1-999, Weightlessness, Gene Expression Profiling, Organic Chemistry, hindlimb unloading, bedrest, Differential regulation, Space Flight, biology.organism_classification, microgravity, Life stage, Bedrest, Microgravity, Neuroscience
Abstract

25 p.-3 fig.-5 tab., Bioinformatics approaches have proven useful in understanding biological responses to spaceflight. Spaceflight experiments remain resource intensive and rare. One outstanding issue is how to maximize scientific output from a limited number of omics datasets from traditional animal models including nematodes, fruitfly, and rodents. The utility of omics data from invertebrate models in anticipating mammalian responses to spaceflight has not been fully explored. Hence, we performed comparative analyses of transcriptomes of soleus and extensor digitorum longus (EDL) in mice that underwent 37 days of spaceflight. Results indicate shared stress responses and altered circadian rhythm. EDL showed more robust growth signals and Pde2a downregulation, possibly underlying its resistance to atrophy versus soleus. Spaceflight and hindlimb unloading mice shared differential regulation of proliferation, circadian, and neuronal signaling. Shared gene regulation in muscles of humans on bedrest and space flown rodents suggest targets for mitigating muscle atrophy in space and on Earth. Spaceflight responses of C. elegans were more similar to EDL. Discrete life stages of D. melanogaster have distinct utility in anticipating EDL and soleus responses. In summary, spaceflight leads to shared and discrete molecular responses between muscle types and invertebrate models may augment mechanistic knowledge gained from rodent spaceflight and ground-based studies., T.C. was supported by the NI Department for the Economy (DfE) Research Studentship. H.C. is supported by the Horizon Centre for Doctoral Training at the University of Nottingham (UKRI grant no. EP/S023305/1). R.H. is supported by the Spanish Plan Estatal de Investigación Científica y Desarrollo Tecnológico Grant RTI2018-099309-B-I00. S.S.R. is supported by the NASA Ames Space Biology Program

Published
2021
Full Text
View/download PDF

9. Revamping Space-omics in Europe

Author

Willian A. da Silveira, Alicia Villacampa, Pedro Madrigal, Daniela Bezdan, F. Javier Medina, Stefania Giacomello, Gary Hardiman, Thomas J. Cahill, Alexander Gabel, Aránzazu Manzano, Stephen D. R. Harridge, Raúl Herranz, Colleen S. Deane, Ivo Grosse, Eugénie Carnero-Diaz, Nathaniel J. Szewczyk, Tessa Eleri Morris-Paterson, Silvio Weging, Madrigal, Pedro [0000-0003-1959-8199], Apollo - University of Cambridge Repository, National Aeronautics and Space Administration (US), Madrigal, Pedro, Manzano, Aranzazu, Deane, Colleen S., Bezdan, Daniela, Carnero-Díaz, Eugénie, Medina, F. Javier, Hardiman, Gary, Grosse, Ivo, Szewczyk, Nathaniel, Weging, Silvio, Giacomello, Stefania, Harridge, Stephen D.R., Da Silveira, William A., Herranz, Raúl, Manzano, Aranzazu [0000-0002-0150-0803], Deane, Colleen S. [0000-0002-2281-6479], Bezdan, Daniela [0000-0002-1203-8239], Carnero-Díaz, Eugénie [0000-0002-3771-3106], Medina, F. Javier [0000-0002-0866-7710], Hardiman, Gary [0000-0003-4558-0400], Grosse, Ivo [0000-0001-5318-4825], Szewczyk, Nathaniel [0000-0003-4425-9746], Weging, Silvio [0000-0002-8484-4352], Giacomello, Stefania [0000-0003-0738-1574], Harridge, Stephen D.R. [0000-0002-8203-0769], Da Silveira, William A. [0000-0001-6370-2884], and Herranz, Raúl [0000-0002-0246-9449]

Subjects
Europe, Histology, SDG 3 - Good Health and Well-being, Humans, Cell Biology, Biology, Space (commercial competition), Space Research, Omics, Data science, Pathology and Forensic Medicine
Abstract

6 p., The authors belong to the ESA Space Omics Topical Team funded by the ESA grant/contract 4000131202/20/NL/PG/pt “Space Omics: Towards an integrated ESA/NASA –omics database for spaceflight and ground facilities experiments” to RH.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results