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Coordination complexes of transition metal cations (CoII, NiII, CuII and ZnII) containing coumarilate and N,N′-diethylnicotinamide were synthesized. The structural characterization and thermal behaviour analysis of novel samples synthesized were conducted through elemental analysis, magnetic susceptibility, solid-state UV–Vis, direct and injection probe mass spectra, FTIR spectra, thermoanalytic TG-DTG/DTA and single crystal X-ray diffraction methods. The structural details of single crystals of [Co(dena)2(H2O)4](coum)2 (I) and [Cu(coum)2(dena)2(H2O)2] (III) complexes were resolved completely. Moreover, the results of analysis obtained for [Ni(coum)2(dena)2(H2O)2] (II) and [Zn(dena)2(H2O)4](coum)2 (IV) complexes were interpreted considering the samples with crystal structures defined and made assumptions about the structural details. It was determined that the complex of CoII metal cation has salt-type structure and the coordination number of metal is accomplished to six as the sum of 4 mol of water and also 2 mol of N,N′-diethylnicotinamide ligands in trans position located within the coordination sphere. It was observed that 2 mol of coumarilate anions are located outside the coordination sphere and have stabilized to the charge (2+) of metal. The CuII complex has totally molecular structure, and the coordination sphere of metal cation was 6 as the sum of 2 mol of water, 2 mol of N,N′-diethylnicotinamide and 2 mol of monoanionic monodentate coumarilate ligands. All ligands have been located in –trans position. The geometry of both complex structures is distorted octahedral. It is assumed that the NiII complex structure is isostructural with CuII complex structure and also does ZnII complex with CoII structure. It was determined that the decomposition products obtained from thermal analysis are the oxides of related metal cations.

The complexes of diphenic acid with CoII and CuII metals and diphenic acid/nicotinamide mixed ligand with CoII and ZnII metals were synthesized and characterized of structural properties by elemental analysis, FT-IR spectra, thermo analytic TG-DTG/DTA and crystal X-ray diffraction methods. The pure ligand complexes of diphenic acid (C14H16O8Co (1), C14H16O8Cu (2)) and mixed ligand complexes of diphenic acid/nicotinamide (C40H38N4O14Co (3), C40H38N4O14Zn (4)) are similar to each other and they have P21, P21/n and space groups. The diphenic acid ligands in 1 and 2 complexes were coordinated to metal cations as dianionic bridge and in the others complexes (3 and 4) it was involved as monoanionic counter ion. The complexes of 1 and 2 are linked into sheets by a combination of O–H⋯O hydrogen bonds and the others complexes of 3 and 4 are linked into sheets by a combination of O–H⋯O, N–H⋯O and C–H⋯O hydrogen bonds. All of the complexes structures have distorted octahedral geometry. According to TG/DTG-DTA analysis, thermal decomposition of complexes starts with dehydration of coordinated aqua ligands. After the dehydration, neutral nicotinamide ligands start to decompose in mixed ligand complexes. Lastly, anionic diphenic acid ligands decompose and corresponding metal oxides remain as residual products of thermal degradation in reaction vessel.

Kumarilik asit benzofuran halkası türevlerinden biridir ve pek çok doğal kaynaktan izole edilebilmektedir. Kumarilik asit ve türevleri çoğu ilaçta etken madde ve endüstrinin birçok dalında aranılan temel malzeme olarak kullanılmaktadır. Kumarilik asit ve türevleri koordinasyon kimyası için önemli ligandlardır ve biyolojik aktiviteleri oldukça dikkat çekicidir. Antifungal, antibakteriyel, antimikrobiyal, antiaritmik, antiaterosklerotik ve kardiyovasküler, antikanser, antidepresan gibi etkiler gösterirler. Ayrıca böbrek taşları ve solunum yolları gibi çeşitli rahatsızlıkların tedavisinde de kullanılmaktadır. Bu tez çalışması kapsamında, kobalt(II), nikel(II), bakır(II) ve çinko(II) geçiş metallerinin kumarilik asit-1,10-fenantrolin/N,N-dietilnikotinamid ligandlarını içeren karışık ligandlı koordinasyon bileşikleri sentezlenerek yapıları aydınlatılmıştır. Yapıları aydınlatılan moleküllerin biyolojik aktivasyonları hücre kültürü ortamında incelenmiştir. Yapılan karakterizasyon sonuçları göz önüne alındığında sentezlenen komplekslerin molekül formüllerinin aşağıdaki gibi olduğu düşünülmektedir: (I) [Co(C9H5O3)2(H2O)4] (III) [Cu(C9H5O3)2(H2O)2] (II) [Ni(C9H5O3)2(H2O)4] (IV) [Zn(C9H5O3)2(H2O)2] (V) [Co(C10H14N2O)2(H2O)4](C9H5O3)2 (VII) [Cu(C9H5O3)2(C10H14N2O)2(H2O)2] (VI) [Ni(C9H5O3)2(C10H14N2O)2(H2O)2] (VIII) [Zn(C10H14N2O)2(H2O)4](C9H5O3)2 (IX) [Co(C12H8N2)2(H2O)2](C9H5O3)25H2O (XI) [Cu(C9H5O3)2(C12H8N2)(H2O)] (X) [Ni(C12H8N2)2(H2O)2](C9H5O3)25H2O (XII) [Zn(C9H5O3)2(C12H8N2)(H2O)] Coumarilic acid is one of the benzofuran ring derivatives and it could isolated from most of natural sources. Coumarilic acid and its derivatives are used as an active substance in lots of medicine and basic material on lots of subdivisions of industry. Coumarilic acid and its derivatives are very important ligands for coordination chemistry and their biological activities draw attention fairly. They influence as antifungal, antibacterial, antimicrobial, antiaritmic, antiatherosclerotic and cardiovascular, anticancer, antidepressant besides they are used treatment of various diseases as kidney stones disease and respiratory tract disease. In this thesis study, cobalt(II), nickel(II), copper(II) and zinc(II) transition metals complex ligand coordination compounds are synthesized –which ones include Coumarilic acid/1,10-phenanthroline/N,N-diethylnicotinamide ligands- thus their structure are explained. The molecules biological activation studies, which ones' structure are explained, are examined in the environment of cell culture. When take attention about the results of characterisation the complexes molecule formulas', which ones are synthesized, are thought as below: (I) [Co(C9H5O3)2(H2O)4] (III) [Cu(C9H5O3)2(H2O)2] (II) [Ni(C9H5O3)2(H2O)4] (IV) [Zn(C9H5O3)2(H2O)2] (V) [Co(C10H14N2O)2(H2O)4](C9H5O3)2 (VII) [Cu(C9H5O3)2(C10H14N2O)2(H2O)2] (VI) [Ni(C9H5O3)2(C10H14N2O)2(H2O)2] (VIII) [Zn(C10H14N2O)2(H2O)4](C9H5O3)2 (IX) [Co(C12H8N2)2(H2O)2](C9H5O3)25H2O (XI) [Cu(C9H5O3)2(C12H8N2)(H2O)] (X) [Ni(C12H8N2)2(H2O)2](C9H5O3)25H2O (XII) [Zn(C9H5O3)2(C12H8N2)(H2O)] İÇİNDEKİLER Sayfa ÖZET -- viii ABSTRACT -- xii TEŞEKKÜR -- xiv İÇİNDEKİLER -- ix ÇİZELGELER DİZİNİ -- xvv ŞEKİLLLER DİZİNİ -- xviiii SİMGELER VE KISALTMALAR -- xxii 1. GİRİŞ -- 1 2. KURAMSAL TEMELLER VE KAYNAK ARAŞTIRMASI -- 3 2.1. Kumarilik Asit (Benzofuran-2-karboksilik asit) -- 3 2.1.1. Kumarilik asidin biyolojik aktiviteleri -- 4 2.1.2. Kumarilik asit (benzofuran-2-karboksilik asit) ile yapılan çalışmalar -- 7 2.2. Benzofuran ve Türevleri -- 16 2.2.1. Doğal benzofuran türevleri -- 17 2.2.2. Benzofuran ve türevlerinin sentez çalıĢmaları -- 19 2.3. Nikotinamid (NA) ve N,N-dietilnikotinamid (DENA) -- 22 2.3.1. Nikotinamid (NA) ve N,N-dietilnikotinamidin (DENA) biyolojik açıdan önemi -- 23 2.3.2. Nikotinamid (NA) ve N,N-dietilnikotinamidin (DENA) metal kompleksleri -- 25 2.4. 1,10-Fenantrolin -- 34 2.4.1. 1,10-Fenantrolin ligandının önemi -- 36 2.4.2. 1,10-Fenantrolin ile yapılan çalışmalar -- 37 3. KOORDİNASYON KİMYASI -- 42 3.1. Koordinasyon Bileşiklerinin Kullanım Alanları -- 47 3.2. Komplekslerin Kararlılıkları -- 49 3.3. Geçiş Metalleri -- 50 4. MATERYAL VE YÖNTEM -- 53 xvii 4.1. Sentez -- 53 4.1.1. Saf Kumarilik asit metal kompleksleri -- 53 4.1.2. KarıĢık ligandlı kumarilik asit / N,N-dietilnikotinamid metal kompleksleri -- 54 4.1.3. Karışık ligandlı kumarilik asit / 1,10-fenantrolin metal kompleksleri -- 54 4.2.Yöntem -- 55 4.2.1. Elementel analiz -- 55 4.2.2. Fourier dönüşümlü kızılötesi spektroskopisi (FT-IR) -- 56 4.2.3. Termik analiz -- 56 4.2.4. Tek kristal X-ışını kırınımı difraktometresi (SC-XRD) -- 58 4.2.5. Manyetik süseptibilite -- 58 4.2.6. Erime noktası tayini -- 59 4.2.7. Ultraviyole-görünür bölge spektroskopisi -- 61 4.2.8. Biyolojik Uygulamaları -- 61 4.2.8.1. Total antioksidan kapasitenin belirlenmesi -- 61 4.2.8.2. Antimikrobiyal aktivitenin belirlenmesi -- 62 5. ARAŞTIRMA SONUÇLARI VE TARTIŞMA -- 63 5.1. Elementel Analiz -- 63 5.2.Fourier Dönüşümlü Kızılötesi Spektroskopisi (FT-IR) -- 66 5.3. Termik Analiz -- 75 5.4. Tek Kristal X-Işını Kırınımı Difraktometresi (SC-XRD) -- 90 5.4.1. [Co(C9H5O3)2(H2O)4] kompleksinin kristal yapısı -- 90 5.4.2. [Ni(C9H5O3)2(H2O)4] kompleksinin kristal yapısı -- 95 5.4.3. [Zn(C9H5O3)2(H2O)2] kompleksinin kristal yapısı -- 102 5.4.4. [Co(C10H14N2O)2(H2O)4](C9H5O3)2 kompleksinin kristal yapısı -- 106 5.4.5. [Cu(C9H5O3)2(C10H14N2O)2(H2O)2] kompleksinin kristal yapısı -- 113 5.4.6. [Ni(C12H8N2)2(H2O)2](C9H5O3)25H2O kompleksinin kristal yapısı -- 122 5.4.7. [Cu(C9H5O3)2(C12H8N2)(H2O)] kompleksinin kristal yapısı -- 131 5.4.8. [Zn(C9H5O3)2(C12H8N2)(H2O)] kompleksinin kristal yapısı -- 138 5.5. Ultraviyole-Görünür Bölge Spektroskopisi -- 146 5.6. Biyolojik Uygulamalar -- 154 6. SONUÇLAR -- 158 KAYNAKLAR -- 1655 ÖZGEÇMİŞ -- 17979