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Purpose. This study investigates the prognostic significance of tumor size and its effect on survival among patients undergoing gastrectomy and D2 lymph node dissection due to gastric cancer. Materials and Methods. The clinicopathological characteristics of 320 patients who were operated due to gastric cancer between November 2006 and September 2019 were assessed retrospectively, of which 271 were included in the present study. A receiver-operating characteristic curve (ROC) analysis was carried out to identify the tumor size cut-off value. Patients were divided into small-size and large-size tumor groups. Clinicopathological characteristics were assessed using Chi-square and Mann-Whitney U tests, while survival was assessed with a Kaplan-Meier log-rank test. Results. The cut-off gastric cancer tumor size value was calculated as 4.75 cm. A statistical difference was noted in the tumor depth of wall invasion (p

Background and Objectives: This study aimed to assess the diagnostic accuracy and prognostic significance of staging laparoscopy (SL) compared to computed tomography (CT) and positron emission tomography–computed tomography (PET-CT) in gastric cancer staging. We evaluated the ability of SL to detect occult peritoneal metastases and influence of SL on survival outcomes across cancer stages and treatment approaches. Materials and Methods: In this retrospective cohort study, 95 patients with gastric cancer underwent preoperative assessment using CT, PET-CT, and SL between 2018 and 2024. Diagnostic performance metrics were calculated for SL, CT, and PET/CT across the local, locally advanced, and metastatic stages. Survival outcomes were analyzed using Kaplan–Meier curves, and comparisons were made using log-rank tests. A multivariable Cox proportional hazards model incorporating interaction terms was used to determine the independent prognostic factors affecting survival, focusing on SL findings and cytology results. Results: The cohort comprised 75 males (78.9%) and 20 females (21.1%), with a mean age of 57.4 ± 10.1 years. The tumor location distribution was predominant in the corpus (31.1%) and cardia. Tumor staging revealed that 48.1% were classified as T3 and 28.8% as T4, respectively. Diagnostic accuracy analysis showed that SL outperformed CT and PET-CT in detecting peritoneal metastasis across all stages. Specifically, SL demonstrated a sensitivity and specificity of 85% and 95% for local disease, 92% and 80% for locally advanced disease, and 95% and 99% for metastatic disease, significantly exceeding those of CT and PET-CT. Patients with SL findings had a median overall survival (OS) of 30 months compared with 20 months for those assessed only with CT and PET-CT (p < 0.05). The stage-specific median OS for SL patients was 40 months in the local, 25 months in the locally advanced (p < 0.05), and 15 months in the metastatic disease (p < 0.01) groups, indicating significant survival benefits. Multivariable Cox regression identified SL findings as an independent factor associated with reduced mortality risk (HR: 0.70, 95% CI: 0.50–0.90, p < 0.01), while positive cytology findings predicted poorer survival (HR: 1.80, 95% CI: 1.25–2.60, p < 0.01). Interaction terms revealed that SL yielded greater survival benefits in patients with metastatic disease (hazard ratio [HR]: 0.60, p < 0.01) and those undergoing systemic therapy (HR: 0.75, p = 0.04). Conclusions: SL provides superior diagnostic accuracy and prognostic information for advanced gastric cancer staging compared with CT and PET-CT. By accurately detecting peritoneal metastasis, SL aids in optimizing treatment plans, particularly in advanced stages, thus potentially improving patient outcomes. [ABSTRACT FROM AUTHOR]

Introduction: Colorectal cancer (CRC) prognosis is typically determined based on clinical stage and histopathological findings, yet patients with the same stage and histological structure can exhibit varying survival outcomes. This highlights the need for additional prognostic biomarkers. Serum biomarkers are gaining increasing significance due to their affordability and accessibility. The albumin-alkaline phosphatase ratio (AAPR) has been associated with prognosis in hepatocellular and gastric cancers, but its role in CRC remains underexplored. Aim: This study aimed to evaluate the effect of the albumin-alkaline phosphatase ratio (AAPR) on the prognosis of patients with colorectal cancer (CRC). Material and method: Data from 358 patients who had undergone surgery for CRC were analyzed retrospectively to identify factors that could predict overall survival (OS). The Roc-Curve test was applied to determine the power of the preoperative AAPR in predicting mortality. Kaplan Meier and log-rank tests were used to examine the survival times of the patients. Results: Our findings revealed that an albumin-alkaline phosphatase cut-off ratio above 0.67 predicted mortality with a sensitivity of 17.54% and a specificity of 92.22%. Although patients with a lower AAPR exhibited a slightly shorter mean survival time compared to those above the cut-off value, this difference did not reach statistical significance (P = .112). Conclusions: The results of this study did not provide evidence to support the AAPR as a potential prognostic factor in patients with colorectal cancer. [ABSTRACT FROM AUTHOR]

Introduction: The main objective of this study is to present 10 Plummer-Vinson Syndrome cases treated and followed up at our clinic alongside cases in current literature. Materials and Methods: The cases of 10 patients with prospective records of Plummer-Vinson Syndrome treated and followed up in the Gastroenterological Surgery Clinic of the hospital were evaluated. Results: Seven (70%) of the patients were female, and three (30%) were male, with a mean age of 45±18. All the patients had a mean hemoglobin value of 8.4±0.94 g/dL and a mean erythrocyte volume level of 63±5.01 fL, and their ferritin levels were 6.5±5.42 ng/dL, which accounted for iron deficiency in the patients. With barium swallow studies before endoscopy, all patients were shown to have esophageal webs. All patients underwent endoscopic balloon dilatation under sedoanalgesia. Three cases of recurrence were observed, and those patients underwent the balloon dilatation process again. Squamous cell carcinoma in the distal esophagus was detected in one case in the 72nd month of follow-up. Conclusion: Endoscopic balloon dilatation together with oral iron replacement is a safe, simple, and efficient mode of treatment. As Plummer-Vinson Syndrome is regarded as a precancerous condition, endoscopic follow-up is required for subsequent treatment. [ABSTRACT FROM AUTHOR]

Introduction: The laparoscopic approach is preferred in colorectal cancer cases, yet concerns arise regarding the development of complications among the elderly patient population. This study aims to investigate the difference in the development of major complications between patients aged 65 and older undergoing laparoscopic procedures for colorectal cancer diagnoses and the younger patients. Materials and Methods: Between 2013 and 2023, records of patients who underwent laparoscopic surgery due to colorectal cancers at our center were extracted. Demographic characteristics, pathology data, complications developed during hospitalization, and lengths of stay were gathered from hospital records. Results: A total of 72 patients were included in the study, with 18 patients aged 65 and older and 54 patients aged younger than 65. When patients were evaluated based on the development of major and minor complications, all demographic and pathological characteristics were found to be similar. Only in the group of patients aged 65 and older, the length of hospital stay was found to be longer (p<0.001). In the multivariate analysis conducted, age was not found to be significant for the development of major complications (OR: 0.895 [0.246-3.264], p=0.897). Conclusion: This study has shown that being aged 65 or older or younger is not associated with the development of major complications in patients undergoing surgery for colorectal cancer. It has also demonstrated that laparoscopic surgical procedures can be safely used in patients aged 65 and older. Further studies with larger patient cohorts could provide more clarity on this topic. [ABSTRACT FROM AUTHOR]

Studies carried out in Europe are of great importance in terms of the history of the Book of Dede Korkut studies. The present study is based on the analytical evaluation of studies conducted in Europe on the Book of Dede Korkut and in foreign languages spoken in Europe. For the list of academic studies in this article, previous bibliographic studies, European and USA-centered databases/online catalogs were utilized. The bibliographic list obtained was classified as "translations" and "selected other works". This study, which has a descriptive character in terms of presenting a bibliographic list on the Book of Dede Korkut, can also be accepted as an analytical review in terms of a holistic evaluation of the studies in question. The present study, which aims to bring the studies on the Book of Dede Korkut in foreign languages to the attention of scholars who read and write in Turkish, to determine the general tendencies of the Dede Korkut researches in Europe and to make a general evaluation based on these determinations, has the purpose of contributing to the corpus of the Book of Dede Korkut researches. In addition, in the light of the data and evaluations put forward, it can be considered as another aim of the article to direct new studies on the Book of Dede Korkut. [ABSTRACT FROM AUTHOR]

Introduction: Cholecystitis is associated with an increased risk of morbidity and mortality in patients under immunosuppressive therapy after lung transplantation. Therefore, cholecystectomy is recommended in patients with asymptomatic cholelithiasis who are candidates for lung transplantation. A pre-transplant prophylactic laparoscopic cholecystectomy approach may reduce this morbidity and mortality in lung transplant candidates with cholelithiasis. In this study, we aimed to examine our experience with laparoscopic cholecystectomy before lung transplantation. Materials and Methods: The data of eight lung transplant candidates who underwent prophylactic laparoscopic cholecystectomy for asymptomatic cholelithiasis were evaluated retrospectively. Results: Of the cases examined, 2 (25%) were female and 6 (75%) were male. The mean age was 34.5 for women and 44.16 for men. No postoperative morbidity or mortality was observed. Conclusion: Prophylactic laparoscopic cholecystectomy can be safely performed before transplantation in patients who are candidates for lung transplantation. [ABSTRACT FROM AUTHOR]

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Introduction: In this study, we aimed to present our experience and findings in high-risk cardiac patients who were inserted percutaneous endoscopic gastrostomy (PEG) tube due to inability to take oral food, prolonged intravenous/nasogastric nutrition, or require long-term enteral feeding. Materials and Methods: A total of 64 patients were examined retrospectively who had PEG tube insertion between 2012 and 2020 in the intensive care unit or clinic by the gastrointestinal surgeon. All patients underwent cardiac surgery before feeding tube insertion. The necessity and short-term results for PEG were evaluated in this patient group. Results: A total of 64 patients underwent upper gastrointestinal endoscopy for insertion of a PEG tube. The procedure was successful in all patients and no complications were observed in the follow-up. Twenty-five (39.1%) of 64 patients were women. The mean age of the patients was 67.04 (±11.44) years. The number of patients for diabetes mellitus, hypertension, atrial fibrillation, cerebrovascular disease, chronic kidney disease, and chronic obstructive/restrictive pulmonary disease was 36 (56.3%), 53 (82.8%), 21 (32.8%), 19 (29.7%), 21 (32.8%), and 15 (23.4%), respectively. The mean hospital stay of the patients after cardiac surgery was 37.81 (±12.81) days, and the mean feeding from PEG tubes was 13.34 (±4.93) days. Conclusion: Patients with high-risk factors who have undergone cardiac surgery are more likely to need a PEG tube. This patient group should be evaluated well in the pre-operative period. Upper gastrointestinal endoscopy should be performed in patients with gastrointestinal symptoms. Furthermore, information should be given about the PEG tube that may be required in the post-operative period. [ABSTRACT FROM AUTHOR]