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1,002 results on '"DUBEY, JITENDER P."'

8. From TgO/GABA-AT, GABA, and T-263 Mutant to Conception of Toxoplasma

Author

Lykins, Joseph, Moschitto, Matthew J., Zhou, Ying, Filippova, Ekaterina V., Le, Hoang V., Tomita, Tadakimi, Fox, Barbara A., Bzik, David J., Su, Chunlei, Rajagopala, Seesandra V., Flores, Kristin, Spano, Furio, Woods, Stuart, Roberts, Craig W., Hua, Cong, El Bissati, Kamal, Wheeler, Kelsey M., Dovgin, Sarah, Muench, Stephen P., McPhillie, Martin, Fishwick, Colin W.G., Anderson, Wayne F., Lee, Patricia J., Hickman, Mark, Weiss, Louis M., Dubey, Jitender P., Lorenzi, Hernan A., Silverman, Richard B., and McLeod, Rima L.

Published
2024
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10. Structure, composition, and roles of the Toxoplasma gondii oocyst and sporocyst walls

Author

Freppel, Wesley, Ferguson, David JP, Shapiro, Karen, Dubey, Jitender P, Puech, Pierre-Henri, and Dumètre, Aurélien

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Biodefense, Infectious Diseases, Foodborne Illness, Prevention, Emerging Infectious Diseases, Vaccine Related, 2.2 Factors relating to the physical environment, Aetiology, Infection, Good Health and Well Being, Environment, Molecules, Oocyst, Sporocyst, Wall structure
Abstract

Toxoplasma gondii is a coccidian parasite with the cat as its definitive host but any warm-blooded animal, including humans, may act as intermediate hosts. It has a worldwide distribution where it may cause acute and chronic toxoplasmosis. Infection can result from ingestion either of tissue cysts in infected meat of intermediate hosts or oocysts found in cat faeces via contaminated water or food. In this review, we highlight how the oocyst and sporocyst walls sustain the persistence and transmission of infective T. gondii parasites from terrestrial and aquatic environments to the host. We further discuss why targeting the oocyst wall structure and molecules may reduce the burden of foodborne and waterborne T. gondii infections.

Published
2019

19. Increased pathogen exposure of a marine apex predator over three decades.

Author

Rode, Karyn D., Van Hemert, Caroline, Wilson, Ryan R., Woodruff, Susannah P., Pabilonia, Kristy, Ballweber, Lora, Kwok, Oliver, and Dubey, Jitender P.

Subjects
GLOBAL environmental change, LEUKOCYTE count, CANINE distemper virus, POLAR bear, BRUCELLA abortus, BRUCELLA, NEOSPORA caninum
Abstract

Environmental changes associated with global warming create new opportunities for pathogen and parasite transmission in Arctic wildlife. As an apex predator ranging over large, remote areas, changes in pathogens and parasites in polar bears are a useful indicator of changing transmission dynamics in Arctic ecosystems. We examined prevalence and risk factors associated with exposure to parasites and viral and bacterial pathogens in Chukchi Sea polar bears. Serum antibodies to six pathogens were detected and prevalence increased between 1987–1994 and 2008–2017 for five: Toxoplasma gondii, Neospora caninum, Francisella tularensis, Brucella abortus/suis, and canine distemper virus. Although bears have increased summer land use, this behavior was not associated with increased exposure. Higher prevalence of F. tularensis, Coxiella burnetii, and B. abortus/suis antibodies in females compared to males, however, could be associated with terrestrial denning. Exposure was related to diet for several pathogens indicating increased exposure in the food web. Elevated white blood cell counts suggest a possible immune response to some pathogens. Given that polar bears face multiple stressors in association with climate change and are a subsistence food, further work is warranted to screen for signs of disease. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Low prevalence of viable Toxoplasma gondii in fresh, unfrozen, American pasture-raised pork and lamb from retail meat stores in the United States

Author

Dubey, Jitender P., Hill, Dolores E., Fournet, Valsin, Hawkins-Cooper, Diane, Cerqueira-Cézar, Camila K., Murata, Fernando H.A., Verma, Shiv K., Kwok, Oliver C.H., Rani, Surabhi, Fredericks, Jorrell, Adams, Brandon, Jones, Jeffrey L., Wiegand, Ryan E., Ying, Yuqing, Guo, Miao, Su, Chunlei, and Pradhan, Abani K.

Published
2020
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31. Global selective sweep of a highly inbred genome of the cattle parasite Neospora caninum

Author

Khan, Asis, Fujita, Ayako Wendy, Randle, Nadine, Regidor-Cerrillo, Javier, Shaik, Jahangheer S., Shen, Kui, Oler, Andrew J., Quinones, Mariam, Latham, Sarah M., Akanmori, Bartholomew D., Cleaveland, Sarah, Innes, Elizabeth A., Ryan, Una, Šlapeta, Jan, Schares, Gereon, Ortega-Mora, Luis M., Dubey, Jitender P., Wastling, Johnathan M., and Grigg, Michael E.

Published
2019

32. Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes.

Author

Lorenzi, Hernan, Khan, Asis, Behnke, Michael S, Namasivayam, Sivaranjani, Swapna, Lakshmipuram S, Hadjithomas, Michalis, Karamycheva, Svetlana, Pinney, Deborah, Brunk, Brian P, Ajioka, James W, Ajzenberg, Daniel, Boothroyd, John C, Boyle, Jon P, Dardé, Marie L, Diaz-Miranda, Maria A, Dubey, Jitender P, Fritz, Heather M, Gennari, Solange M, Gregory, Brian D, Kim, Kami, Saeij, Jeroen PJ, Su, Chunlei, White, Michael W, Zhu, Xing-Quan, Howe, Daniel K, Rosenthal, Benjamin M, Grigg, Michael E, Parkinson, John, Liu, Liang, Kissinger, Jessica C, Roos, David S, and Sibley, L David

Subjects
Toxoplasma, Protozoan Proteins, DNA, Protozoan, RNA, Messenger, Phylogeny, Virulence, Gene Expression Regulation, Conserved Sequence, Synteny, Polymorphism, Single Nucleotide, Genome, Protozoan, DNA, Protozoan, Genome, Polymorphism, Single Nucleotide, RNA, Messenger
Abstract

Toxoplasma gondii is among the most prevalent parasites worldwide, infecting many wild and domestic animals and causing zoonotic infections in humans. T. gondii differs substantially in its broad distribution from closely related parasites that typically have narrow, specialized host ranges. To elucidate the genetic basis for these differences, we compared the genomes of 62 globally distributed T. gondii isolates to several closely related coccidian parasites. Our findings reveal that tandem amplification and diversification of secretory pathogenesis determinants is the primary feature that distinguishes the closely related genomes of these biologically diverse parasites. We further show that the unusual population structure of T. gondii is characterized by clade-specific inheritance of large conserved haploblocks that are significantly enriched in tandemly clustered secretory pathogenesis determinants. The shared inheritance of these conserved haploblocks, which show a different ancestry than the genome as a whole, may thus influence transmission, host range and pathogenicity.

Published
2016

34. Sarcocystis caninum and Sarcocystis svanai n. spp. (Apicomplexa: Sarcocystidae) Associated with Severe Myositis and Hepatitis in the Domestic Dog (Canis familiaris)

Author

Dubey, Jitender P, Sykes, Jane E, Shelton, G Diane, Sharp, Nick, Verma, Shiv K, Calero‐Bernal, Rafael, Viviano, Jenifer, Sundar, Natarajan, Khan, Asis, and Grigg, Michael E

Subjects
Infection, Good Health and Well Being, Animals, British Columbia, Cluster Analysis, Colorado, DNA, Ribosomal, Dog Diseases, Dogs, Hepatitis, Animal, Microscopy, Molecular Sequence Data, Montana, Multilocus Sequence Typing, Myositis, Phylogeny, Polymerase Chain Reaction, RNA, Ribosomal, 18S, Sarcocystis, Sarcocystosis, Canada, dog, USA, Microbiology, Zoology, Mycology & Parasitology
Abstract

There are several reports of Sarcocystis sarcocysts in muscles of dogs, but these species have not been named. Additionally, there are two reports of Sarcocystis neurona in dogs. Here, we propose two new names, Sarcocystis caninum, and Sarcocystis svanai for sarcocysts associated with clinical muscular sarcocystosis in four domestic dogs (Canis familiaris), one each from Montana and Colorado in the USA, and two from British Columbia, Canada. Only the sarcocyst stage was identified. Most of the sarcocysts identified were S. caninum. Sarcocysts were studied using light microscopy, transmission electron microscopy (TEM), and polymerase chain reaction. Based on collective results two new species, S. caninum and S. svanai were designated. Sarcocystis caninum and S. svanai were structurally distinct. Sarcocystis caninum sarcocysts were up to 1.2 mm long and up to 75 μm wide. By light microscopy, the sarcocyst wall was relatively thin and smooth. By TEM, the sarcocyst wall was "type 9", 1-2 μm thick, and contained villar protrusions that lacked microtubules. Bradyzoites in sections were 7-9 μm long. Sarcocysts of S. svanai were few and were identified by TEM. Sarcocystis svanai sarcocysts were "type 1", thin walled (< 0.5 μm), and the wall lacked villar protrusions but had tiny blebs that did not invaginate. DNA was extracted either from infected frozen muscle biopsies or formalin-fixed paraffin-embedded sections. Dogs were either singly infected with S. caninum or multiply co-infected with S. caninum and S. svanai (the result of a mixed infection) based on multilocus DNA sequencing and morphology. BLASTn analysis established that the sarcocysts identified in these dogs were similar to, but not identical to Sarcocystis canis or Sarcocystis arctosi, parasites found to infect polar bears (Ursus maritimus) or brown bears (Ursus arctosi), respectively. However, the S. caninum sequence showed 100% identify over the 18S rRNA region sequenced to that of S. arctica, a parasite known to infect Arctic foxes (Vulpes lagopus).

Published
2015

47. Experimental Neospora caninum infection in chickens (Gallus gallus domesticus) with oocysts and tachyzoites of two recent isolates reveals resistance to infection

Author

Oliveira, Solange, Aizawa, Juliana, Soares, Herbert Sousa, Chiebao, Daniela Pontes, Castro, Márcio Botelho de, Hora, Aline S., Lopes, Marcos Gomes, Schares, Gereon, Jenkins, Mark C., Kwok, Oliver C.H., Dias, Ricardo Augusto, Gennari, Solange Maria, Dubey, Jitender P., and Pena, Hilda Fátima Jesus

Published
2018
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