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Objective To analyze the correlation between gastric mucosa serological biopsy ［serum pepsinogen Ⅰ（PGⅠ）, pepsinogen Ⅱ（PGⅡ）, ratio of PGⅠ/PGⅡ(PGR), gastrin-17 and helicobacter pyloriantibody（HP-IgG）］ and histological gastritis evaluation criteria （OLGA/OLGIM）, and to evaluate the efficacy of these indicators in the screening of gastric precancerous disease. Methods A total of 417 patients underwent gastroscopy for dyspepsia were selected in the 971st Hospital of the PLA Navy from January 2019 to December 2021 were selected. They were evaluated in groups according to the OLGA/OLGIM staging system, and the serum PGⅠ, PGⅡ, PGR, G-17 and HP-IgG were detected and analyzed. Results In OLGA/OLGIM group, PGⅠ and PGR decreased with the increase of group grade(P＜0.01), while the infection rates of G-17 and HP increased with the increase of group grade(P＜0.01). Kendall correlation analysis showed that there was a positive correlation between the combined scoring method and OLGA stage and OLGIM stage (r=0.44, 0.43,P

The aim of this study was to ascertain the diagnostic value of serum squamous cell carcinoma antigen (SCCA) and SCCA-IgM for hepatocellular carcinoma (HCC). After a comprehensive search of PubMed and Web of Science databases, we identified eligible studies on the diagnostic value serum SCCAs for HCC. The quality of the eligible studies was assessed using the revised Quality Assessment for Studies of Diagnostic Accuracy (QUADAS-2) tool. The overall diagnostic value of SCCAs for HCC was pooled using a bivariate model. Twelve studies were included in this systematic review and meta-analysis. The pooled sensitivities for SCCA and SCCA-IgM were 0.61 (95% confidence interval [CI], 0.37–0.81) and 0.70 (95% CI, 0.55–0.82), respectively. The corresponding specificities were 0.80 (95% CI, 0.52–0.94) and 0.62 (95% CI, 0.51–0.72), respectively. The areas under summary receiver operating characteristic (sROC) curves for SCCA and SCCA-IgM were 0.76 (95% CI, 0.72–0.80) and 0.70 (95% CI, 0.66–0.74), respectively. Major design deficiencies of the included studies were two-gate design and partial verification bias. Therefore, we concluded that both serum SCCA and SCCA-IgM have a fair diagnostic value for HCC. [ABSTRACT FROM PUBLISHER]

Objective: To investigate the changes of the mast cells (MCs) and substance P (SP), and to elucidate their possible roles in visceral hypersensitivity in patients with irritable bowel syndrome (IBS)., Methods: In 22 diarrhea-predominant IBS, 20 constipation-predominant IBS and 19 controls, the biopsies were carried out from the terminal ileum, the ileocecal junction, the ascending colon, and the sigmoid colon. The MCs and the SP-ergic nerve terminals, SP receptor (SPR) cells were stained by histochemistry and immunohistochemistry respectively, and the results were investigated qualitatively and quantitatively by color image analyzer. The biopsies of the ICJ and the sigmoid colon were measured by radioimmunoassay. The structure relation between the MCs and SP-ergic terminals, SPR-ergic cells were studied through an ultramicroscopy using in situ embedding technique and a light microscopic study in serial sections respectively., Results: The number of MCs in the terminal ileum, the ileocecal junction, and the ascending colon were significantly elevated in IBS patients (P < 0.01), and the MCs in IBS have great variations. Significantly increased the SP-ergic nerve terminals were found in patients with IBS of intestine compared with the control. The correlation between mucosal MC and the SP-ergic nerve terminals was found, and MCs were close to these terminals in lamina propria, which were demonstrated SP-ergic nerve terminals. Some MCs were demonstrated to be SPR-positive cells., Conclusions: The MCs and SP of intestinal mucosa may play a central role in the gut hypersensitivity in both motor response and visceral perception in IBS.