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Your search keyword '"DINDA, Amit K."' showing total 403 results
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403 results on '"DINDA, Amit K."'

3. Unsupervised organization of cervical cells using high resolution digital holographic microscopy

Author

Mangal, Jyoti, Monga, Rashi, Mathur, Sandeep R., Dinda, Amit K., Joseph, Joby, Ahlawat, Sarita, and Khare, Kedar

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Physics - Medical Physics
Abstract

We report results on unsupervised organization of cervical cells using microscopy of Pap-smear samples in brightfield (3-channel colour) as well as high resolution quantitative phase imaging modalities. A number of morphological parameters are measured for each of the 1450 cell nuclei (from $10$ woman subjects) imaged in this study. The Principal Component Analysis (PCA) methodology applied to this data shows that the cell image clustering performance improves significantly when brightfield as well as phase information is utilized for PCA as compared to when brightfield-only information is used. The results point to the feasibility of an image-based tool that will be able to mark suspicious cells for further examination by the pathologist. More importantly our results suggest that the information in quantitative phase images of cells that is typically not used in clinical practice is valuable for automated cell classification applications in general.

Published
2018

27. ENDGAMES

Author

Hadda, Vijay, Khilnani, Gopi C, Kumar, Arvind, Dinda, Amit K, Sedgwick, Philip, Ranu, Harpreet, Buyck, Hubertus, Willis, Fenella, and Madden, Brendan

Published
2011

44. Graphene nanofiber composites for enhanced neuronal differentiation of human mesenchymal stem cells.

Author

Rawat, Sonali, Jain, Krishan Gopal, Gupta, Deepika, Raghav, Pawan Kumar, Chaudhuri, Rituparna, Pinky, Shakeel, Adeeba, Arora, Varun, Sharma, Harshita, Debnath, Debika, Kalluri, Ankarao, Agrawal, Ashwini K., Jassal, Manjeet, Dinda, Amit K., Patra, Prabir, and Mohanty, Sujata

Abstract

Aim: To differentiate mesenchymal stem cells into functional dopaminergic neurons using an electrospun polycaprolactone (PCL) and graphene (G) nanocomposite. Methods: A one-step approach was used to electrospin the PCL nanocomposite, with varying G concentrations, followed by evaluating their biocompatibility and neuronal differentiation. Results: PCL with exiguous graphene demonstrated an ideal nanotopography with an unprecedented combination of guidance stimuli and substrate cues, aiding the enhanced differentiation of mesenchymal stem cells into dopaminergic neurons. These newly differentiated neurons were seen to exhibit unique neuronal arborization, enhanced intracellular Ca2+ influx and dopamine secretion. Conclusion: Having cost-effective fabrication and room-temperature storage, the PCL-G nanocomposites could pave the way for enhanced neuronal differentiation, thereby opening a new horizon for an array of applications in neural regenerative medicine. [ABSTRACT FROM AUTHOR]

Published
2021
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48. A rare case of low-grade myofibroblastic sarcoma of the femur in a 38-year-old woman: a case report

Author

Sharma Alok, Gupta Ruchika, Arora Raman, and Dinda Amit K

Subjects
Medicine
Abstract

Abstract Introduction Primary myofibroblastic sarcoma of the bone is a rare spindle cell tumour with, to the best of our knowledge, only eight cases reported in the available English language literature. The disease's rarity and its low-grade features make an accurate diagnosis difficult in most cases. The differential diagnoses of this unusual tumour include various benign entities as well as other sarcomas. Due to the difference in prognosis, a precise pathologic diagnosis is essential, which requires a combination of thorough morphologic examination, immunohistochemistry and electron microscopy wherever available. Case presentation We report the case of a 38-year-old Indian woman with a lytic lesion in her left femur. The tumour was associated with cortical destruction and soft tissue extension. A biopsy from the soft tissue component showed features suggestive of a low-grade malignant mesenchymal tumour. Excision of the tumour was performed and histopathological examination showed a low-grade spindle cell sarcoma with collagenous stroma. Expressions of vimentin and smooth muscle actin were also noted. Ultrastructural examination confirmed its myofibroblastic nature. A final diagnosis of low-grade myofibroblastic sarcoma of the left femur was thus rendered. Conclusion Low-grade myofibroblastic sarcoma is one of the rarer osseous spindle cell sarcomas depicting a favourable prognosis in the cases reported so far. Its diagnosis requires ancillary techniques like immunohistochemistry and electron microscopy. To the best of our knowledge, we report the ninth case in the literature and the first case from our subcontinent.

Published
2010
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