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1. Potential antitumor agents. 34.(1) Synthesis and antitumor activity of guanylhydrazones from imidazo[2,1-b]thiazoles and from diimidazo[1,2-a: 1,2-c] pyrimidine

Author

Andreani, A., Granaiola, M., ALBERTO LEONI, Locatelli, A., Morigi, R., Rambaldi, M., Giorgi, G., Garaliene, V., ANDREANI A., GRANAIOLA M., LEONI A., LOCATELLI A., MORIGI R., RAMBALDI M., GIORGI G., and GARALIENE V.

Subjects
Molecular Structure, IMIDAZO[2, Hydrazones, Imidazoles, Antineoplastic Agents, DIIMIDAZO[1, Crystallography, X-Ray, Guanidines, ANTITUMOR ACTIVITY, 2-A:1, Thiazoles, GUANYLHYDRAZONES, Pyrimidines, Cell Line, Tumor, Humans, 2-C]PYRIMIDINE, Drug Screening Assays, Antitumor, 1-B]THIAZOLE
Abstract

We report the synthesis of new guanylhydrazones from imidazo[2,1-b]thiazoles and of a bis-guanylhydrazone from diimidazo[1,2-a:1,2-c]pyrimidine. The compounds were tested as potential antitumor agents at the National Cancer Institute. Two derivatives are now under review by BEC: one of these was also subjected to a test for positive inotropic activity in view of a possible coanthracyclinic activity. Tyrosine kinase receptors may be involved as molecular targets in the mechanism of action of the guanylhydrazones described.

Published
2004

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