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2. Comparing clinical profiles, in-hospital complications and one-year cerebrovascular events in typical and midventricular TTS-results from a retrospective study between two third-level centers

Author

Vanni, F, primary, Duran-Cambra, A, additional, Tavecchia, G, additional, Stratinaki, M, additional, Padilla-Lopez, M, additional, Agostini, C, additional, Scheggi, V, additional, Rodriguez-Sotelo, L, additional, Vila-Perales, M, additional, Bragagnini, W, additional, Pena-Ortega, P, additional, Pons-Monne, M, additional, Sionis, A, additional, and Di Mario, C, additional

Published
2024
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3. Multi-dimensional evaluation in patients with aortic stenosis who are candidates for cardiac surgery

Author

Bonanni, F, primary, Berteotti, M, additional, Grasso Granchietti, A, additional, Tozzetti, V, additional, Cenni, N, additional, Marchi, E, additional, Bandini, M, additional, Servoli, C, additional, Grandi, G, additional, Del Pace, S, additional, Targetti, M, additional, Di Mario, C, additional, Stefano, P L, additional, and Caciolli, S, additional

Published
2023
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5. Clinical impact of high platelet reactivity in patients with atrial fibrillation and concomitant percutaneous coronary intervention on dual or triple antithrombotic therapy

Author

Berteotti, M, primary, Gori, A M, additional, Giusti, B, additional, Fortini, A, additional, Grossi, G, additional, Ciardetti, N, additional, Migliorini, A, additional, Lotti, E, additional, Valenti, R, additional, Di Mario, C, additional, Marchionni, N, additional, and Marcucci, R, additional

Published
2023
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11. Role of continuous glucose monitoring in diabetic patients at high cardiovascular risk: an expert-based multidisciplinary Delphi consensus

Author

Di Mario, C, Genovese, S, Lanza, G, Mannucci, E, Marenzi, G, Sciatti, E, Pitocco, D, Avogaro, A, Bertuzzi, F, Bonora, E, Borghi, C, Buzzetti, R, Carugo, S, Capodanno, D, Consoli, A, Conti, A, Danesi, R, Bartolo, P, Ferrari, G, Favale, S, Giorda, C, Giorgino, F, Girelli, A, Golino, P, Grigioni, F, Indolfi, C, Irace, C, Lovati, E, Maffettone, A, Masulli, M, Oliva, F, Oltrona Visconti, L, Orsi, E, Pagotto, U, Paloscia, L, Parati, G, Perrone, P, Piccirillo, G, Pozzilli, P, Pugliese, G, Purrello, F, Ribichini, F, Rubboli, A, Senni, M, Trevisan, R, Tubili, C, Uguccioni, M, Di Mario C., Genovese S., Lanza G. A., Mannucci E., Marenzi G., Sciatti E., Pitocco D., Avogaro A., Bertuzzi F., Bonora E., Borghi C., Buzzetti R., Carugo S., Capodanno D., Consoli A., Conti A., Danesi R., Bartolo P., Ferrari G. M. D., Favale S., Giorda C., Giorgino F., Girelli A., Golino P., Grigioni F., Indolfi C., Irace C., Lovati E., Maffettone A., Masulli M., Oliva F. G., Oltrona Visconti L., Orsi E., Pagotto U., Paloscia L., Parati G., Perrone P., Piccirillo G., Pozzilli P., Pugliese G., Purrello F., Ribichini F., Rubboli A., Senni M., Trevisan R., Tubili C., Uguccioni M., Di Mario, C, Genovese, S, Lanza, G, Mannucci, E, Marenzi, G, Sciatti, E, Pitocco, D, Avogaro, A, Bertuzzi, F, Bonora, E, Borghi, C, Buzzetti, R, Carugo, S, Capodanno, D, Consoli, A, Conti, A, Danesi, R, Bartolo, P, Ferrari, G, Favale, S, Giorda, C, Giorgino, F, Girelli, A, Golino, P, Grigioni, F, Indolfi, C, Irace, C, Lovati, E, Maffettone, A, Masulli, M, Oliva, F, Oltrona Visconti, L, Orsi, E, Pagotto, U, Paloscia, L, Parati, G, Perrone, P, Piccirillo, G, Pozzilli, P, Pugliese, G, Purrello, F, Ribichini, F, Rubboli, A, Senni, M, Trevisan, R, Tubili, C, Uguccioni, M, Di Mario C., Genovese S., Lanza G. A., Mannucci E., Marenzi G., Sciatti E., Pitocco D., Avogaro A., Bertuzzi F., Bonora E., Borghi C., Buzzetti R., Carugo S., Capodanno D., Consoli A., Conti A., Danesi R., Bartolo P., Ferrari G. M. D., Favale S., Giorda C., Giorgino F., Girelli A., Golino P., Grigioni F., Indolfi C., Irace C., Lovati E., Maffettone A., Masulli M., Oliva F. G., Oltrona Visconti L., Orsi E., Pagotto U., Paloscia L., Parati G., Perrone P., Piccirillo G., Pozzilli P., Pugliese G., Purrello F., Ribichini F., Rubboli A., Senni M., Trevisan R., Tubili C., and Uguccioni M.

Abstract

Background: Continuous glucose monitoring (CGM) shows in more detail the glycaemic pattern of diabetic subjects and provides several new parameters (“glucometrics”) to assess patients’ glycaemia and consensually guide treatment. A better control of glucose levels might result in improvement of clinical outcome and reduce disease complications. This study aimed to gather an expert consensus on the clinical and prognostic use of CGM in diabetic patients at high cardiovascular risk or with heart disease. Methods: A list of 22 statements concerning type of patients who can benefit from CGM, prognostic impact of CGM in diabetic patients with heart disease, CGM use during acute cardiovascular events and educational issues of CGM were developed. Using a two-round Delphi methodology, the survey was distributed online to 42 Italian experts (21 diabetologists and 21 cardiologists) who rated their level of agreement with each statement on a 5-point Likert scale. Consensus was predefined as more than 66% of the panel agreeing/disagreeing with any given statement. Results: Forty experts (95%) answered the survey. Every statement achieved a positive consensus. In particular, the panel expressed the feeling that CGM can be prognostically relevant for every diabetic patient (70%) and that is clinically useful also in the management of those with type 2 diabetes not treated with insulin (87.5%). The assessment of time in range (TIR), glycaemic variability (GV) and hypoglycaemic/hyperglycaemic episodes were considered relevant in the management of diabetic patients with heart disease (92.5% for TIR, 95% for GV, 97.5% for time spent in hypoglycaemia) and can improve the prognosis of those with ischaemic heart disease (100% for hypoglycaemia, 90% for hyperglycaemia) or with heart failure (87.5% for hypoglycaemia, 85% for TIR, 87.5% for GV). The experts retained that CGM can be used and can impact the short- and long-term prognosis during an acute cardiovascular event. Lastly, CGM has a

Published
2022

12. Discrepancy between angiography and intravascular ultrasound when analysing small coronary arteries

Author

Briguori, C, Tobis, J, Nishida, T, Vaghetti, M, Albiero, R, Di Mario, C, and Colombo, A

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Clinical Research, Biomedical Imaging, Cardiovascular, Atherosclerosis, Aged, Arteries, Coronary Angiography, Coronary Artery Disease, Coronary Vessels, Female, Humans, Incidence, Italy, Male, Middle Aged, Predictive Value of Tests, Reference Values, Ultrasonography, Interventional, small vessels, quantitative coronary angiography, intravascular ultrasound, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

AimsA small reference diameter may be the consequence of high plaque burden and diffuse disease. The reference vessel diameter in small coronary arteries may vary according to the method of measurement used. We endeavoured to confirm the difference between data from examinations conducted using angiography with that revealed by intravascular ultrasound.Methods and resultsBetween March 1993 and October 1999, 344 consecutive patients with 419 lesions in small vessels (< or =2.75 mm, Small group) and 953 patients with 1161 lesions in large vessels (Large group) underwent intravascular ultrasound-guided percutaneous transluminal angioplasty in our Institution. The mean difference between the intravascular ultrasound and the angiographic reference diameter (Delta(IVUS-Angio)) was 1.3+/-0.5 mm in the Small group and 1.0+/-0.6 mm in the Large group (P or =0.30 mm occurred in 99.5% of cases in the Small group and in 90% in the Large group (P or =0.50 mm occurred in 96% of case in the Small group and 80% in the Large group (P or =0.50 in the Small group were: proximal or middle lesion site, vessel type (left anterior descending artery, diagonal and obtuse marginal branches) and female sex. An Delta(IVUS-Angio)> or =1.0 mm occurred in 71% of cases in the Small group and in 49% in the Large group (P or =1.0 mm in the Small group were: proximal or middle lesion site, female sex, and lesion length.ConclusionsA high percentage of vessels measuring < or =2.75 mm are large vessels with a high plaque burden. This condition is particularly prevalent in females, with lesions in the proximal or middle left anterior descending artery, and in obtuse marginal and diagonal branches.

Published
2002

17. POS1353 SEMIQUANTITATIVE ASSESSMENT OF KNEE OSTEOARTHRITIS-RELATED SYNOVITIS COMPARED TO CHRONIC INFLAMMATORY ARTHRITIDES: RELATION TO AGE AND IMPACT ON BONE/STRUCTURAL DAMAGE

Author

Rubortone, P., primary, Leone, F., additional, Petricca, L., additional, Perniola, S., additional, Bruno, D., additional, Gigante, M. R., additional, Di Mario, C., additional, Tolusso, B., additional, Peluso, G., additional, Gremese, E., additional, D’agostino, M. A., additional, Alivernini, S., additional, and Lizzio, M. M., additional

Published
2023
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18. POS0425 SINGLE-CELL RNA SEQUENCING OF SYNOVIAL TISSUE-DERIVED MYELOID CELLS IN PSORIATIC ARTHRITIS PATIENTS ACROSS DISEASE PHASES

Author

Bruno, D., primary, Somma, D., additional, Tolusso, B., additional, Di Mario, C., additional, Coletto, L. A., additional, Elmesmari, A., additional, Petricca, L., additional, Gigante, M. R., additional, Perniola, S., additional, Paglionico, A., additional, Varriano, V., additional, Peluso, G., additional, D’agostino, M. A., additional, Gremese, E., additional, Kurowska-Stolarska, M., additional, and Alivernini, S., additional

Published
2023
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19. POS0867 B-CELL SUBSETS IN PERIPHERAL BLOOD ACROSS DISEASE PHASES OF PSORIATIC ARTHRITIS AND THEIR CORRELATION WITH SYNOVIAL TISSUE FEATURES

Author

Bruno, D., primary, Tolusso, B., additional, DI Mario, C., additional, Perniola, S., additional, Somma, D., additional, Petricca, L., additional, Chiricozzi, A., additional, Gigante, M. R., additional, D’amore, A., additional, Kurowska-Stolarska, M., additional, Alivernini, S., additional, and Gremese, E., additional

Published
2023
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20. POS0904 INTENSIVE TRAINING PROGRAM FOR ULTRASOUND-GUIDED MINIMALLY INVASIVE SYNOVIAL TISSUE BIOPSY PROCEDURE ON SMALL AND LARGE JOINTS IN DIFFERENT PHASES OF JOINT INFLAMMATION

Author

Coletto, L. A., primary, Marino, V., additional, Rizzo, C., additional, Verardi, L., additional, Bruno, D., additional, Rubortone, P., additional, Goulas, N., additional, D’antonio, A., additional, Gessi, M., additional, DI Mario, C., additional, Tolusso, B., additional, Bui, L., additional, Chimenti, M. S., additional, Guggino, G., additional, Ciccia, F., additional, Caporali, R., additional, Gremese, E., additional, D’agostino, M. A., additional, Lizzio, M. M., additional, and Alivernini, S., additional

Published
2023
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21. POS1485 SEMIQUANTITATIVE ASSESSMENT OF SYNOVIAL INFLAMMATION ON US-GUIDED SYNOVIAL TISSUE BIOPSIES OF SYSTEMIC LUPUS ERYTHEMATOSUS COMPARED TO OTHER CONNECTIVE TISSUE DISEASES AND RHEUMATOID ARTHRITIS

Author

DI Mario, C., primary, Petricca, L., additional, Paglionico, A., additional, Varriano, V., additional, Gigante, M. R., additional, Perniola, S., additional, Bruno, D., additional, Tolusso, B., additional, Alivernini, S., additional, and Gremese, E., additional

Published
2023
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24. Case report: Dupilumab treatment improved type 2 disorders in a patient with IPEX syndrome diagnosis

Author

Caruso, Cristiano, Laterza, Lucrezia, Settanni, Carlo Romano, Colantuono, S., Di Mario, Clara, Tolusso, Barbara, Castri, Federica, Gremese, Elisa, Scaldaferri, Franco, Armuzzi, Alessandro, De Simone, Clara, Peris, Ketty, Chiricozzi, Andrea, Gasbarrini, Antonio, Caruso C., Laterza L., Settanni C. R., Di Mario C., Tolusso B. (ORCID:0000-0002-9108-6609), Castri F., Gremese E. (ORCID:0000-0002-2248-1058), Scaldaferri F. (ORCID:0000-0001-8334-7541), Armuzzi A. (ORCID:0000-0003-1572-0118), De Simone C. (ORCID:0000-0002-0898-0045), Peris K. (ORCID:0000-0002-5237-0463), Chiricozzi A. (ORCID:0000-0002-6739-0387), Gasbarrini A. (ORCID:0000-0002-7278-4823), Caruso, Cristiano, Laterza, Lucrezia, Settanni, Carlo Romano, Colantuono, S., Di Mario, Clara, Tolusso, Barbara, Castri, Federica, Gremese, Elisa, Scaldaferri, Franco, Armuzzi, Alessandro, De Simone, Clara, Peris, Ketty, Chiricozzi, Andrea, Gasbarrini, Antonio, Caruso C., Laterza L., Settanni C. R., Di Mario C., Tolusso B. (ORCID:0000-0002-9108-6609), Castri F., Gremese E. (ORCID:0000-0002-2248-1058), Scaldaferri F. (ORCID:0000-0001-8334-7541), Armuzzi A. (ORCID:0000-0003-1572-0118), De Simone C. (ORCID:0000-0002-0898-0045), Peris K. (ORCID:0000-0002-5237-0463), Chiricozzi A. (ORCID:0000-0002-6739-0387), and Gasbarrini A. (ORCID:0000-0002-7278-4823)

Abstract

We described a case of IPEX syndrome successfully controlled with dupilumab, an anti-IL4 receptor alpha subunit inhibitor. IPEX syndrome is a rare and generally fatal genetic disorder characterized by immune dysregulation, polyendocrinopathy and enteropathy, mostly diagnosed in early childhood. Nonetheless, cases reported in the last 20 years demonstrated that IPEX clinical spectrum encompasses more than the classical triad of early-onset intractable diarrhea, type 1 diabetes and eczema. Atypical cases of IPEX include patients with late-onset of symptoms, single-organ involvement, mild disease phenotypes or rare clinical features. A 21-year-old caucasian man presented with immune dysregulation (hypereosinophilia and elevated IgE), protein-losing enteropathy, polyendocrinopathy (thyroiditis, osteoporosis, delayed puberty), weight loss, eczema manifestations and celiac disease. IPEX syndrome was diagnosed because of the presence of a hemizygous mutation in FOXP3 gene (c.543C>T (p.S181S) in the exon 5). During the course of the disease, the patient developed erosive proctitis, pyoderma gangrenosum, and erythema nodosum. Symptoms improved only after enteral and parenteral corticosteroid therapy and the patient soon developed steroid-dependence. Notwithstanding various therapies including azathioprine, sirolimus, tacrolimus, adalimumab, vedolizumab, the patient failed to achieve a good control of symptoms without steroids. Almost exclusive enteral nutrition with a hypoallergenic, milk-protein free, amino acid-based food for special medical purposes. He continued to lose weight (BMI 14.5 kg/m2) with a consequent high limitation of physical activity and a progressive worsening of the quality of life. In consideration of the poor response to conventional immunosuppressants and the presence of type 2 inflammatory manifestations, treatment with dupilumab at an initial dose of 600 mg, followed by a maintenance dose of 300 mg every other week, according to atopic dermatitis

Published
2023

25. Bifurcation lesions: two stents versus one stent--immediate and follow-up results.

Author

Yamashita, T, Nishida, T, Adamian, MG, Briguori, C, Vaghetti, M, Corvaja, N, Albiero, R, Finci, L, Di Mario, C, Tobis, JM, and Colombo, A

Subjects
Humans, Coronary Disease, Recurrence, Coronary Angiography, Treatment Outcome, Severity of Illness Index, Incidence, Hospital Mortality, Risk Factors, Follow-Up Studies, Stents, Aged, Middle Aged, Female, Male, Angioplasty, Balloon, Coronary, Angioplasty, Balloon, Coronary, Cardiovascular System & Hematology, Cardiorespiratory Medicine and Haematology, Public Health and Health Services
Abstract

ObjectivesThe purpose of this study was to evaluate two different techniques of stent placement in bifurcation lesions.BackgroundAlthough stent placement with dedicated techniques has been suggested to be a useful therapeutic modality for bifurcation lesions, limited information is available if stent placement on the side branch and on the parent branch provides any advantage over a simpler strategy of stenting the parent vessel and balloon angioplasty of the side branch.MethodsBetween March 1993 and April 1999, we treated a total of 92 patients with bifurcation lesions with two strategies: stenting both vessels (group B, n = 53) or stenting the parent vessel and balloon angioplasty of the side branch (group P, n = 39). Paired angiograms were analyzed by quantitative angiography, and clinical follow-up was obtained.ResultsStent placement on both branches resulted in a lower residual stenosis (7.4 +/- 10.9% vs. 23.4% +/- 18.7%, p < 0.001) in the side branch. Acute procedural success was similar in the two groups (group B: 87% vs. Group P: 92%). In-hospital major adverse cardiac events (MACE) occurred only in group B (13% vs. 0%, p < 0.05). At the six-month follow-up, the angiographic restenosis rate (group B: 62% vs. Group P: 48%) and the target lesion revascularization rate (38% vs. 36%, respectively) were similar in the two groups. There was no difference in the incidence of six-month total MACE (51% vs. 38%).ConclusionsFor the treatment of true bifurcation lesions, a complex strategy of stenting both vessels provided no advantage in terms of procedural success and late outcome versus a simpler strategy of stenting only the parent vessel.

Published
2000

26. Angiographic and intravascular ultrasound predictors of in-stent restenosis.

Author

Kasaoka, S, Tobis, JM, Akiyama, T, Reimers, B, Di Mario, C, Wong, ND, and Colombo, A

Subjects
Humans, Coronary Disease, Coronary Angiography, Ultrasonography, Interventional, Multivariate Analysis, Prospective Studies, Stents, Forecasting, Aged, Middle Aged, Female, Male, Secondary Prevention, Ultrasonography, Interventional, Cardiovascular System & Hematology, Cardiorespiratory Medicine and Haematology, Public Health and Health Services
Abstract

ObjectivesThis study was performed to determine predictors of in-stent restenosis from a high volume, single-center practice.BackgroundIntracoronary stents have been shown to reduce the restenosis rate as compared with balloon angioplasty, but in-stent restenosis continues to be an important clinical problem.MethodsBetween April 1993 and March 1997, 1,706 patients with 2,343 lesions were treated with a variety of intracoronary stents. The majority of stents were placed with high pressure balloon inflations and intravascular ultrasound (IVUS) guidance. Angiographic follow-up was obtained in 1,173 patients with 1,633 lesions (70%). Clinical, angiographic and IVUS variables were prospectively recorded and analyzed by univariate and multivariate models for the ability to predict the occurrence of in-stent restenosis defined as a diameter stenosis > or =50%.ResultsIn-stent restenosis was angiographically documented in 282 patients with 409 lesions (25%). The restenosis group had a significantly longer total stent length, smaller reference lumen diameter, smaller final minimal lumen diameter (MLD) by angiography and smaller stent lumen cross-sectional area (CSA) by IVUS. In lesions where IVUS guidance was used, the restenosis rate was 24% as compared with 29% if IVUS was not used (p < 0.05). By multivariate logistic regression analysis, longer total stent length, smaller reference lumen diameter and smaller final MLD were strong predictors of in-stent restenosis. In lesions with IVUS guidance, IVUS stent lumen CSA was a better independent predictor than the angiographic measurements.ConclusionsAchieving an optimal stent lumen CSA by using IVUS guidance during the procedure and minimizing the total stent length may reduce in-stent restenosis.

Published
1998

27. Comparison of immediate and intermediate-term results of intravascular ultrasound versus angiography-guided Palmaz-Schatz stent implantation in matched lesions.

Author

Albiero, R, Rau, T, Schlüter, M, Di Mario, C, Reimers, B, Mathey, DG, Tobis, JM, Schofer, J, and Colombo, A

Subjects
Coronary Vessels, Humans, Coronary Disease, Recurrence, Coronary Angiography, Ultrasonography, Retrospective Studies, Stents, Adult, Aged, Middle Aged, Female, Male, stents, coronary disease, ultrasonics, angiography, restenosis, Cardiovascular System & Hematology, Clinical Sciences, Cardiorespiratory Medicine and Haematology, Public Health and Health Services
Abstract

BackgroundIntravascular ultrasound (IVUS) provides more precise information than angiography about vascular dimensions. This information is used by some centers to optimize intracoronary stent implantation. There are no direct comparisons of the effects on restenosis of optimal IVUS-guided versus angiography-directed high-pressure stenting.Methods and resultsLesions of patients who had a 6-month angiographic follow-up study were eligible for matching. From 445 consecutive lesions treated by Palmaz-Schatz (P-S) stenting guided by IVUS (IVUS group) in Milan, 173 lesions were individually matched with 173 of 476 consecutive lesions treated by P-S stenting directed by angiography (Angio group) in Hamburg. Lesions were selected by a computerized program according to baseline clinical, angiographic, and procedural variables. Immediate and 6-month angiographic results were retrospectively compared, distinguishing an "early phase" from a "late phase." This distinction was based on the more aggressive dilation strategy with larger balloons and more demanding IVUS criteria for optimal stent expansion used in Milan in the early phase. In both phases, a larger minimum lumen diameter (MLD) immediately after stenting and after 6 months was achieved in the IVUS group than in the Angio group. In the early phase, the dichotomous restenosis rate was lower in the IVUS group than in the Angio group (9.2% versus 22.3%; P=.04). In the late phase, there was no difference in restenosis between the groups (22.7% versus 23.7%; P=1.0).ConclusionsIn matched lesions treated with high-pressure stenting, IVUS guidance achieved a larger MLD than angiographic guidance. However, in the IVUS group, the restenosis rate was lower only in the early phase, when balloons larger than currently used were selected to maximize the stent lumen area.

Published
1997

28. Coronary stenting after rotational atherectomy in calcified and complex lesions. Angiographic and clinical follow-up results.

Author

Moussa, I, Di Mario, C, Moses, J, Reimers, B, Di Francesco, L, Martini, G, Tobis, J, and Colombo, A

Subjects
Humans, Coronary Disease, Coronary Thrombosis, Calcinosis, Recurrence, Aspirin, Ticlopidine, Warfarin, Heparin, Fibrinolytic Agents, Coronary Angiography, Ultrasonography, Atherectomy, Coronary, Retrospective Studies, Follow-Up Studies, Stents, Aged, Middle Aged, Female, Male, stents, balloon, calcium, Atherectomy, Coronary, Cardiovascular System & Hematology, Clinical Sciences, Cardiorespiratory Medicine and Haematology, Public Health and Health Services
Abstract

BackgroundTreatment of calcified (in contrast to simple) lesions with PTCA has been associated with a lower success rate and more procedural complications. Rotablation can improve acute results, but the high restenosis rate remains a problem. The purpose of this study was to evaluate the clinical and angiographic outcome of patients with complex and calcified lesions treated with a combination of rotablation and stenting.Methods and resultsSeventy-five consecutive patients with 106 lesions had rotablation prior to coronary stenting. Intravascular ultrasound-guided stenting was used without subsequent anticoagulation in 93% of patients. Procedural success was achieved in 93.4% of lesions. Acute stent thrombosis occurred in two lesions (1.9%), and subacute stent thrombosis in one lesion (0.9%). Angiographic follow-up was performed in 82.5% of lesions at 4.6 +/- 1.9 months with an angiographic restenosis rate of 22.5%. Clinical follow-up was performed in all patients at 6.4 +/- 3 months; target lesion revascularization was needed in 18% of lesions; Q-wave myocardial infarction occurred in 1.3%, coronary bypass surgery in 4.0%, and death in 1.3%.ConclusionsOptimal coronary stenting after rotablation in calcified and complex lesions can be performed with a high success rate, an acceptable rate of procedural complications, and a low rate of stent thrombosis. This approach was associated with a low incidence of angiographic restenosis compared with results usually obtained with other interventional strategies in calcified and complex lesion subsets.

Published
1997

29. First experience with imaging core wires.

Author

Di Mario, C, Akiyama, T, Moussa, I, Reimers, B, Jang, YT, Tobis, J, and Colombo, A

Subjects
Fluid Mechanics and Thermal Engineering, Engineering, Biomedical Imaging, Cardiovascular, Bioengineering, Assistive Technology, Angioplasty, Balloon, Coronary, Coronary Disease, Equipment Design, Feasibility Studies, Humans, Stents, Ultrasonography, Interventional
Abstract

This study is the first assessment of feasibility and clinical usefulness of an imaging wire. The device used is a 0.018" flexible cable mounting a 30 MHz piezoelectric crystal at the end. The only possible application of the wire in its current configuration is the assessment of balloon expansion with over-the-wire balloon catheters. In this study, 17 lesions were examined in 14 patients. Despite careful removal of the air, no image could be obtained with the balloon deflated or through the shaft of conventional balloon catheters. When the balloon was inflated to 1-4 atm the circular echo-free cross-section of the balloon became visible, surrounded by the dense line of the balloon membrane and by the vessel wall. By examining the stent area at different balloon pressures, it was possible to determine the stent recoil between maximal balloon expansion and lowest balloon pressure allowing a readable ultrasound image. These encouraging preliminary observations confirm the feasibility of the use of an ultrasound guidewire for monitoring balloon expansion during stent implantation. After high pressure inflation, a moderate reduction of the stent lumen was observed during deflation, compatible with the small recoil predicted for the stainless-steel mesh stent used.

Published
1997

30. Subacute stent thrombosis in the era of intravascular ultrasound-guided coronary stenting without anticoagulation: frequency, predictors and clinical outcome.

Author

Moussa, I, Di Mario, C, Reimers, B, Akiyama, T, Tobis, J, and Colombo, A

Subjects
Humans, Coronary Disease, Coronary Thrombosis, Aspirin, Ticlopidine, Anticoagulants, Platelet Aggregation Inhibitors, Coronary Angiography, Ultrasonography, Interventional, Treatment Outcome, Incidence, Logistic Models, Case-Control Studies, Retrospective Studies, Follow-Up Studies, Stents, Causality, Time Factors, Middle Aged, Female, Male, Ultrasonography, Interventional, Cardiovascular System & Hematology, Cardiorespiratory Medicine and Haematology, Public Health and Health Services
Abstract

ObjectivesThis study was performed to determine predictors of subacute stent thrombosis (SST) in the era of intravascular ultrasound (IVUS)-guided coronary stenting without anticoagulation.BackgroundThe incidence of stent thrombosis has declined with the application of high pressure stent deployment with only antiplatelet therapy. However, no data are available on predictors of stent thrombosis in this era.MethodsBetween March 30, 1993 and July 31, 1995, 1,042 consecutive patients underwent coronary stenting without anticoagulation. For this analysis, we excluded patients who underwent coronary artery bypass surgery, died or had acute stent thrombosis within the 1st 24 h after stenting (41 patients). A total of 1,001 patients (1,334 lesions) were included; 982 patients (1,315 lesions) without SST and 19 patients (19 lesions) with SST.ResultsThe rate of SST was 1.9% (per patient). There was no difference between the SST and No SST groups in rescue stenting (12% vs. 13.5%, p = 1.0) or mean +/- SD reference diameter (3.11 +/- 0.58 vs. 3.19 +/- 0.53 mm, p = 0.54). A preexisting thrombus was present in 12% of the SST group and in 4.5% of the No SST group (p = 0.19). Predictors of SST by univariate analysis were low ejection fraction (p = 0.004), more stents per lesion (p = 0.049), use of combination of different stents (p = 0.012), smaller balloon size (p = 0.012) and suboptimal result in terms of smaller lumen dimensions by angiography (p = 0.016) and IVUS (p = 0.004), residual dissections (p = 0.027) and slow flow (p = 0.0001). In stepwise logistic regression analysis, ejection fraction (p = 0.019), use of a combination of different stents (p = 0.013) and postprocedure dissections (p = 0.014) and slow flow (p = 0.0001) were predictive of SST.ConclusionsIn the present era of stent implantation, factors that may predispose to SST are low ejection fraction, intraprocedural complications leading to utilization of more stents, particularly with different stent designs, and suboptimal final result in terms of smaller lumen dimensions and persistent slow flow and dissections.

Published
1997

32. Case report: Dupilumab treatment improved type 2 disorders in a patient with IPEX syndrome diagnosis

Author

Caruso, C., primary, Laterza, L., additional, Settanni, C. R., additional, Colantuono, S., additional, Di Mario, C., additional, Tolusso, B., additional, Castrì, F., additional, Gremese, E., additional, Scaldaferri, F., additional, Armuzzi, A., additional, De Simone, C., additional, Peris, K., additional, Chiricozzi, A., additional, and Gasbarrini, A., additional

Published
2023
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34. Renal denervation for the management of resistant hypertension

Author

Patel HC, Hayward C, Vassiliou V, Patel K, Howard JP, and Di Mario C

Subjects
Resistant hypertension, Renal denervation, Sympathetic nervous system, Symplicity, Internal medicine, RC31-1245
Abstract

Hitesh C Patel,1 Carl Hayward,1 Vassilis Vassiliou,1 Ketna Patel,2 James P Howard,3 Carlo Di Mario11NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London, UK; 2Department of Cardiology, Royal Free Hospital, London, UK; 3National Heart and Lung Institute, Imperial College, London, UKAbstract: Renal sympathetic denervation (RSD) as a therapy for patients with resistant hypertension has attracted great interest. The majority of studies in this field have demonstrated impressive reductions in blood pressure (BP). However, these trials were not randomized or sham-controlled and hence, the findings may have been overinflated due to trial biases. SYMPLICITY HTN-3 was the first randomized controlled trial to use a blinded sham-control and ambulatory BP monitoring. A surprise to many was that this study was neutral. Possible reasons for this neutrality include the fact that RSD may not be effective at lowering BP in man, RSD was not performed adequately due to limited operator experience, patients’ adherence with their antihypertensive drugs may have changed during the trial period, and perhaps the intervention only works in certain subgroups that are yet to be identified. Future studies seeking to demonstrate efficacy of RSD should be designed as randomized blinded sham-controlled trials. The efficacy of RSD is in doubt, but many feel that its safety has been established through the thousands of patients in whom the procedure has been performed. Over 90% of these data, however, are for the Symplicity™ system and rarely extend beyond 12 months of follow-up. Long-term safety cannot be assumed with RSD and nor should it be assumed that if one catheter system is safe then all are. We hope that in the near future, with the benefit of well-designed clinical trials, the role of renal denervation in the management of hypertension will be established.Keywords: resistant hypertension, renal denervation, sympathetic nervous system, symplicity

Published
2015

35. Procedural outcomes and annual operator volume among patients treated with percutaneous coronary intervention of chronic total occlusions – analysis based on a large national registry

Author

Januszek, R, primary, Bryniarski, L, additional, Siudak, Z, additional, Malinowski, K P, additional, Surowiec, S, additional, Wanha, W, additional, Wojakowski, W, additional, Bryniarski, K, additional, Legutko, J, additional, Kambis, M, additional, Di Mario, C, additional, Bartus, K, additional, and Bartus, S, additional

Published
2022
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40. Retrograde Chronic Total Occlusion Percutaneous Coronary Interventions: Predictors of Procedural Success From the ERCTO Registry

Author

Myat A., Galassi A. R., Werner G. S., Mashayekhi K., Avran A., Boudou N., Meyer-Gessner M., Reifart N., Lesiak M., Garbo R., Bufe A., Spratt J., Bryniarski L., Christiansen E. H., Sianos G., Escaned J., di Mario C., Hildick-Smith D., Myat A., Galassi A.R., Werner G.S., Mashayekhi K., Avran A., Boudou N., Meyer-Gessner M., Reifart N., Lesiak M., Garbo R., Bufe A., Spratt J., Bryniarski L., Christiansen E.H., Sianos G., Escaned J., di Mario C., and Hildick-Smith D.

Subjects
coronary collateral, percutaneous coronary intervention, retrograde, chronic total occlusion, antegrade
Abstract

Objectives: The aim of this study was to identify independent predictors of procedural success after retrograde chronic total occlusion (CTO) percutaneous coronary intervention (PCI). Background: Retrograde CTO PCI is an established technique, but predictors of success remain poorly understood. Methods: A multivariable logistic regression model was used to analyze potentially important demographic, clinical, anatomical, and technical aspects of retrograde CTO PCI cases uploaded to the multicenter European CTO (ERCTO) Club Registry. Results: In calendar years 2018 and 2019, 2,364 retrograde CTO PCI cases constituted the primary analysis cohort. A primary retrograde strategy was used in 1,953 cases (82.6%), and an initial antegrade approach was converted to retrograde in 411 cases (17.4%). Procedural success was achieved in 1,820 cases (77.0%) and was more likely to occur after a primary retrograde attempt versus conversion from an initial antegrade approach (80.9% vs 58.4%; P < 0.0001). After multivariable analysis, an absence of lesion calcification (OR: 1.86; 95% CI: 1.37-2.51; P < 0.0001), a higher degree of distal vessel opacification (OR: 2.47; 95% CI: 1.72-3.55; P < 0.0001), little or no proximal target vessel tortuosity (OR: 1.84; 95% CI: 1.28-2.64; P = 0.001), Werner collateral connection CC1 (OR: 4.87; 95% CI: 2.90-8.19; P < 0.0001) or CC2 (OR: 5.33; 95% CI: 3.02-9.42; P < 0.0001), and the top tertile of operator volume (>120 cases over 2 years) (OR: 1.88; 95% CI: 1.26-2.79; P = 0.002) were associated with the greatest chance of achieving angiographic success. Conclusions: Less calcification with good distal vessel opacification, little or absent proximal vessel tortuosity, and visible collateral connections, along with high-volume operator status, were all independently predictive of angiographically successful retrograde CTO PCI.

Published
2022

41. Basophil activation and serum IL-5 levels as possible monitor biomarkers in severe eosinophilic asthma patients treated with anti-IL-5 drugs

Author

Caruso, C., Colantuono, S., Tolusso, B., Di Mario, C., Pentassuglia, A., Rumi, G., Gremese, E., Romano, A., Gasbarrini, A., Caruso C., Tolusso B. (ORCID:0000-0002-9108-6609), Di Mario C., Gremese E. (ORCID:0000-0002-2248-1058), Gasbarrini A. (ORCID:0000-0002-7278-4823), Caruso, C., Colantuono, S., Tolusso, B., Di Mario, C., Pentassuglia, A., Rumi, G., Gremese, E., Romano, A., Gasbarrini, A., Caruso C., Tolusso B. (ORCID:0000-0002-9108-6609), Di Mario C., Gremese E. (ORCID:0000-0002-2248-1058), and Gasbarrini A. (ORCID:0000-0002-7278-4823)

Abstract

N/a

Published
2021

42. Blood lactate predicts survival after percutaneous implantation of extracorporeal life support for refractory cardiac arrest or cardiogenic shock complicating acute coronary syndrome: insights from the CareGem registry

Author

Porto, I., Mattesini, A., D'Amario, D., Sorini Dini, C., Della Bona, R., Scicchitano, M., Vergallo, R., Martellini, A., Caporusso, S., Trani, C., Burzotta, F., Bruno, P., Di Mario, C., Crea, F., Valente, S., Massetti, M., Porto I. (ORCID:0000-0002-9854-5046), D'Amario D., Scicchitano M. (ORCID:0000-0002-9599-6642), Vergallo R., Trani C. (ORCID:0000-0001-9777-013X), Burzotta F. (ORCID:0000-0002-6569-9401), Bruno P. (ORCID:0000-0002-1075-5808), Di Mario C., Crea F. (ORCID:0000-0001-9404-8846), Valente S. (ORCID:0000-0003-4052-9200), Massetti M. (ORCID:0000-0002-7100-8478), Porto, I., Mattesini, A., D'Amario, D., Sorini Dini, C., Della Bona, R., Scicchitano, M., Vergallo, R., Martellini, A., Caporusso, S., Trani, C., Burzotta, F., Bruno, P., Di Mario, C., Crea, F., Valente, S., Massetti, M., Porto I. (ORCID:0000-0002-9854-5046), D'Amario D., Scicchitano M. (ORCID:0000-0002-9599-6642), Vergallo R., Trani C. (ORCID:0000-0001-9777-013X), Burzotta F. (ORCID:0000-0002-6569-9401), Bruno P. (ORCID:0000-0002-1075-5808), Di Mario C., Crea F. (ORCID:0000-0001-9404-8846), Valente S. (ORCID:0000-0003-4052-9200), and Massetti M. (ORCID:0000-0002-7100-8478)

Abstract

Refractory cardiogenic shock (RCS) or refractory cardiac arrest (RCA) complicating acute coronary syndrome (ACS) is associated with extremely high mortality rate. Veno-arterial extracorporeal life support (VA-ECLS) represents a valuable therapeutic option to stabilize patients’ condition before or at the time of emergency revascularization. We analyzed 29 consecutive patients with RCS or RCA complicating ACS, and implanted with VA-ECLS in two centers who have adopted a similar, structured approach to ECLS implantation. Data were collected from January 2010 to December 2015 and ECLS had to be percutaneously implanted either before (within 48 h) or at the time of attempted percutaneous coronary revascularization (PCI). We investigated in-hospital outcome and factors associated with survival. Twenty-one (72%) were implanted for RCA, whereas 8 (28%) were implanted on ECLS for RCS. All RCA were witnessed and no-flow time was shorter than 5 min in all cases but one. All patients underwent attempted emergency PCI, using radial access in ten cases (34.5%), whereas in three patients a subsequent CABG was performed. Overall, ten patients (34.5%) survived, nine of them with a good neurological outcome. Life threatening complications, including stroke (4 pts), leg ischemia (4 pts), intestinal ischemia (5 pts), and deep vein thrombosis 2 pts), occurred frequently, but were not associated with in-hospital death. Main cause of death was multi-organ failure. PCI variables did not predict survival. Survivors were younger, with shorter low-flow time, and with ECLS mainly implanted for RCS. At multivariate analysis, levels of lactate at ECLS implantation (OR 4.32, 95%CI 1.01–18.51, p = 0.049) emerged as the only variable that independently predicted survival. In patients with RCA or RCS complicating ACS who are percutaneously implanted with ECLS before or at the time of coronary revascularization, in hospital survival rate is higher than 30%. Level of lactate at ECLS im

Published
2021

44. Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era

Author

De Rosa, S, Spaccarotella, C, Basso, C, Calabro, M, Curcio, A, Filardi, P, Mancone, M, Mercuro, G, Muscoli, S, Nodari, S, Pedrinelli, R, Sinagra, G, Indolfi, C, Angelini, F, Barilla, F, Bartorelli, A, Benedetto, F, Bernabo, P, Bolognese, L, Briani, M, Cacciavillani, L, Calabrese, A, Calabro, P, Caliendo, L, Calo, L, Casella, G, Casu, G, Cavallini, C, Ciampi, Q, Ciccone, M, Comito, M, Corrada, E, Crea, F, D'Andrea, A, D'Urbano, M, De Caterina, R, De Ferrari, G, De Ponti, R, Della Mattia, A, DI Mario, C, Donnazzan, L, Esposito, G, Fedele, F, Ferraro, A, Galasso, G, Galie, N, Gnecchi, M, Golino, P, Golia, B, Guarini, P, Leonardi, S, Locuratolo, N, Luzza, F, Manganiello, V, Francesca Marchetti, M, Marenzi, G, Margonato, A, Meloni, L, Metra, M, Milo, M, Mongiardo, A, Monzo, L, Morisco, C, Novo, G, Pancaldi, S, Parollo, M, Paterno, G, Patti, G, Priori, S, Ravera, A, Giuseppe Rebuzzi, A, Rossi, M, Scherillo, M, Semprini, F, Senni, M, Sibilio, G, Siviglia, M, Tamburino, C, Tortorici, G, Versace, F, Villari, B, Volpe, M, De Rosa S., Spaccarotella C., Basso C., Calabro M. P., Curcio A., Filardi P. P., Mancone M., Mercuro G., Muscoli S., Nodari S., Pedrinelli R., Sinagra G., Indolfi C., Angelini F., Barilla F., Bartorelli A., Benedetto F., Bernabo P., Bolognese L., Briani M., Cacciavillani L., Calabrese A., Calabro P., Caliendo L., Calo L., Casella G., Casu G., Cavallini C., Ciampi Q., Ciccone M., Comito M., Corrada E., Crea F., D'Andrea A., D'Urbano M., De Caterina R., De Ferrari G., De Ponti R., Della Mattia A., DI Mario C., Donnazzan L., Esposito G., Fedele F., Ferraro A., Galasso G., Galie N., Gnecchi M., Golino P., Golia B., Guarini P., Leonardi S., Locuratolo N., Luzza F., Manganiello V., Francesca Marchetti M., Marenzi G., Margonato A., Meloni L., Metra M., Milo M., Mongiardo A., Monzo L., Morisco C., Novo G., Pancaldi S., Parollo M., Paterno G., Patti G., Priori S., Ravera A., Giuseppe Rebuzzi A., Rossi M., Scherillo M., Semprini F., Senni M., Sibilio G., Siviglia M., Tamburino C., Tortorici G., Versace F., Villari B., Volpe M., De Rosa, S, Spaccarotella, C, Basso, C, Calabro, M, Curcio, A, Filardi, P, Mancone, M, Mercuro, G, Muscoli, S, Nodari, S, Pedrinelli, R, Sinagra, G, Indolfi, C, Angelini, F, Barilla, F, Bartorelli, A, Benedetto, F, Bernabo, P, Bolognese, L, Briani, M, Cacciavillani, L, Calabrese, A, Calabro, P, Caliendo, L, Calo, L, Casella, G, Casu, G, Cavallini, C, Ciampi, Q, Ciccone, M, Comito, M, Corrada, E, Crea, F, D'Andrea, A, D'Urbano, M, De Caterina, R, De Ferrari, G, De Ponti, R, Della Mattia, A, DI Mario, C, Donnazzan, L, Esposito, G, Fedele, F, Ferraro, A, Galasso, G, Galie, N, Gnecchi, M, Golino, P, Golia, B, Guarini, P, Leonardi, S, Locuratolo, N, Luzza, F, Manganiello, V, Francesca Marchetti, M, Marenzi, G, Margonato, A, Meloni, L, Metra, M, Milo, M, Mongiardo, A, Monzo, L, Morisco, C, Novo, G, Pancaldi, S, Parollo, M, Paterno, G, Patti, G, Priori, S, Ravera, A, Giuseppe Rebuzzi, A, Rossi, M, Scherillo, M, Semprini, F, Senni, M, Sibilio, G, Siviglia, M, Tamburino, C, Tortorici, G, Versace, F, Villari, B, Volpe, M, De Rosa S., Spaccarotella C., Basso C., Calabro M. P., Curcio A., Filardi P. P., Mancone M., Mercuro G., Muscoli S., Nodari S., Pedrinelli R., Sinagra G., Indolfi C., Angelini F., Barilla F., Bartorelli A., Benedetto F., Bernabo P., Bolognese L., Briani M., Cacciavillani L., Calabrese A., Calabro P., Caliendo L., Calo L., Casella G., Casu G., Cavallini C., Ciampi Q., Ciccone M., Comito M., Corrada E., Crea F., D'Andrea A., D'Urbano M., De Caterina R., De Ferrari G., De Ponti R., Della Mattia A., DI Mario C., Donnazzan L., Esposito G., Fedele F., Ferraro A., Galasso G., Galie N., Gnecchi M., Golino P., Golia B., Guarini P., Leonardi S., Locuratolo N., Luzza F., Manganiello V., Francesca Marchetti M., Marenzi G., Margonato A., Meloni L., Metra M., Milo M., Mongiardo A., Monzo L., Morisco C., Novo G., Pancaldi S., Parollo M., Paterno G., Patti G., Priori S., Ravera A., Giuseppe Rebuzzi A., Rossi M., Scherillo M., Semprini F., Senni M., Sibilio G., Siviglia M., Tamburino C., Tortorici G., Versace F., Villari B., and Volpe M.

Abstract

Aims: To evaluate the impact of the COVID-19 pandemic on patient admissions to Italian cardiac care units (CCUs). Methods and Results: We conducted a multicentre, observational, nationwide survey to collect data on admissions for acute myocardial infarction (AMI) at Italian CCUs throughout a 1 week period during the COVID-19 outbreak, compared with the equivalent week in 2019. We observed a 48.4% reduction in admissions for AMI compared with the equivalent week in 2019 (P < 0.001). The reduction was significant for both ST-segment elevation myocardial infarction [STEMI; 26.5%, 95% confidence interval (CI) 21.7-32.3; P = 0.009] and non-STEMI (NSTEMI; 65.1%, 95% CI 60.3-70.3; P < 0.001). Among STEMIs, the reduction was higher for women (41.2%; P = 0.011) than men (17.8%; P = 0.191). A similar reduction in AMI admissions was registered in North Italy (52.1%), Central Italy (59.3%), and South Italy (52.1%). The STEMI case fatality rate during the pandemic was substantially increased compared with 2019 [risk ratio (RR) = 3.3, 95% CI 1.7-6.6; P < 0.001]. A parallel increase in complications was also registered (RR = 1.8, 95% CI 1.1-2.8; P = 0.009). Conclusion: Admissions for AMI were significantly reduced during the COVID-19 pandemic across Italy, with a parallel increase in fatality and complication rates. This constitutes a serious social issue, demanding attention by the scientific and healthcare communities and public regulatory agencies.

Published
2020

45. Accuracy of the PARIS score and PCI complexity to predict ischemic events in patients treated with very thin stents in unprotected left main or coronary bifurcations

Author

Gallone, G., D'Ascenzo, F., Conrotto, F., Costa, F., Capodanno, D., Muscoli, S., Chieffo, A., Yoichi, I., Pennacchi, M., Quadri, G., Nunez-Gil, I., Bocchino, P. P., Piroli, F., De Filippo, O., Rolfo, C., Wojakowski, W., Trabattoni, D., Huczek, Z., Venuti, G., Montabone, A., Rognoni, A., Parma, R., Figini, F., Mitomo, S., Boccuzzi, G., Mattesini, A., Cerrato, E., Wanha, W., Smolka, G., Cortese, B., Ryan, N., Bo, M., di Mario, C., Varbella, F., Burzotta, F., Sheiban, I., Escaned, J., Helft, G., De Ferrari, G. M., D'Ascenzo F., di Mario C., Burzotta F. (ORCID:0000-0002-6569-9401), Gallone, G., D'Ascenzo, F., Conrotto, F., Costa, F., Capodanno, D., Muscoli, S., Chieffo, A., Yoichi, I., Pennacchi, M., Quadri, G., Nunez-Gil, I., Bocchino, P. P., Piroli, F., De Filippo, O., Rolfo, C., Wojakowski, W., Trabattoni, D., Huczek, Z., Venuti, G., Montabone, A., Rognoni, A., Parma, R., Figini, F., Mitomo, S., Boccuzzi, G., Mattesini, A., Cerrato, E., Wanha, W., Smolka, G., Cortese, B., Ryan, N., Bo, M., di Mario, C., Varbella, F., Burzotta, F., Sheiban, I., Escaned, J., Helft, G., De Ferrari, G. M., D'Ascenzo F., di Mario C., and Burzotta F. (ORCID:0000-0002-6569-9401)

Abstract

Background: The PARIS risk score (PARIS-rs) and percutaneous coronary intervention complexity (PCI-c) predict clinical and procedural residual ischemic risk following PCI. Their accuracy in patients undergoing unprotected left main (ULM) or bifurcation PCI has not been assessed. Methods: The predictive performances of the PARIS-rs (categorized as low, intermediate, and high) and PCI-c (according to guideline-endorsed criteria) were evaluated in 3,002 patients undergoing ULM/bifurcation PCI with very thin strut stents. Results: After 16 (12–22) months, increasing PARIS-rs (8.8% vs. 14.1% vs. 27.4%, p <.001) and PCI-c (15.2% vs. 11%, p =.025) were associated with higher rates of major adverse cardiac events ([MACE], a composite of death, myocardial infarction [MI], and target vessel revascularization), driven by MI/death for PARIS-rs and target lesion revascularization/stent thrombosis for PCI-c (area under the curves for MACE: PARIS-rs 0.60 vs. PCI-c 0.52, p-for-difference <.001). PCI-c accuracy for MACE was higher in low-clinical-risk patients; while PARIS-rs was more accurate in low-procedural-risk patients. ≥12-month dual antiplatelet therapy (DAPT) was associated with a lower MACE rate in high PARIS-rs patients, (adjusted-hazard ratio 0.42 [95% CI: 0.22–0.83], p =.012), with no benefit in low to intermediate PARIS-rs patients. No incremental benefit with longer DAPT was observed in complex PCI. Conclusions: In the setting of ULM/bifurcation PCI, the residual ischemic risk is better predicted by a clinical risk estimator than by PCI complexity, which rather appears to reflect stent/procedure-related events. Careful procedural risk estimation is warranted in patients at low clinical risk, where PCI complexity may substantially contribute to the overall residual ischemic risk.

Published
2020

46. Fatigue in Covid-19 survivors: The potential impact of a nutritional supplement on muscle strength and function

Author

Galluzzo, Vincenzo, Zazzara, Maria Beatrice, Ciciarello, Francesca, Savera, Giulia, Pais, C., Calvani, Riccardo, Picca, A., Marzetti, Emanuele, Landi, Francesco, Tosato, Matteo, Steering, Committee, Gremese, Elisa, Coordination, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Field, Investigator, Gastroenterology, Team, Porcari, Serena, Settanni, Carlo Romano, Geriatric, Team, Benvenuto, F., Bramato, Giulia, Brandi, Vincenzo, Carfi, A., Fabrizi, Sofia, Lo Monaco, Maria Rita, Martone, Anna Maria, Napolitano, C., Pagano, Francesco Cosimo, Rocchi, Sara, Rota, E., Salerno, Andrea Maria, Tritto, M., Catalano, Lucio, Damiano, Francesco Paolo, Rocconi, Alessandra, Galliani, Alessandro, Spaziani, G., Tupputi, Salvatore, Cocchi, Camilla, Pirone, Flavia, D'Ignazio, F., Cacciatore, Stefano, Infectious disease, Team, Cauda, Roberto, Tamburrini, Enrica, Borghetti, Alberto, Di Gianbenedetto, S., Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, E., Moschese, D., Ciccullo, A., Dusina, A., Internal Medicine, Team, Stella, L., Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Geltrude, Zocco, Maria Assunta, Microbiology, Team, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, M., Neurology, Team, Bizzarro, Alessandra, Lauria, Alessandra, Ophthalmology, Team, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Cozzupoli, G. M., Culiersi, Carola, Otolaryngology, Team, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, F., Di Cintio, G., Longobardi, Ylenia, Tricarico, Laura, Santantonio, M., Pediatric, Team, Buonsenso, Danilo, Valentini, Piero, Pata, D., Sinatti, Dario, De Rose, Cristina, Pneumology, Team, Richeldi, Luca, Lombardi, F., Calabrese, Anna Chiara, Leone, Paolo Maria, Calvello, M. R., Intini, Enrica, Montemurro, G., Psychiatric, Team, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Giuseppin, G., Molinaro, M., Odica, M., Radiology, Team, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Rheumatology, Team, Paglionico, A., Petricca, Luca, Gigante, Lavinia, Natalello, G., Fedele, Anna Laura, Lizzio, Marco Maria, Tolusso, Barbara, Di Mario, Clara, Alivernini, Stefano, Vascular, Team, Santoliquido, Angelo, Santoro, L., Di Giorgio, A., Nesci, A., Popolla, Valentina, Galluzzo V., Zazzara M. B., Ciciarello F., Savera G., Calvani R. (ORCID:0000-0001-5472-2365), Marzetti E. (ORCID:0000-0001-9567-6983), Landi F. (ORCID:0000-0002-3472-1389), Tosato M., Gremese E. (ORCID:0000-0002-2248-1058), Bernabei R. (ORCID:0000-0002-9197-004X), Fantoni M. (ORCID:0000-0001-6913-8460), Gasbarrini A. (ORCID:0000-0002-7278-4823), Porcari S., Settanni C. R., Bramato G., Brandi V., Fabrizi S., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Martone A. M., Pagano F. C., Rocchi S., Salerno A., Catalano L., Damiano F. P., Rocconi A., Galliani A., Tupputi S., Cocchi C., Pirone F., Cacciatore S., Cauda R. (ORCID:0000-0002-1498-4229), Tamburrini E. (ORCID:0000-0003-4930-426X), Borghetti A., Murri R. (ORCID:0000-0003-4263-7854), Cingolani A. (ORCID:0000-0002-3793-2755), Ventura G. (ORCID:0000-0002-0304-7264), Addolorato G. (ORCID:0000-0002-1522-9946), Franceschi F. (ORCID:0000-0001-6266-445X), Mingrone G. (ORCID:0000-0003-2021-528X), Zocco M. A. (ORCID:0000-0002-0814-9542), Sanguinetti M. (ORCID:0000-0002-9780-7059), Cattani P. (ORCID:0000-0003-4678-4763), Marchetti S., Posteraro B. (ORCID:0000-0002-1663-7546), Bizzarro A., Lauria A., Rizzo S. (ORCID:0000-0001-6302-063X), Savastano M. C. (ORCID:0000-0003-1397-4333), Gambini G., Culiersi C., Passali G. C. (ORCID:0000-0002-8176-0962), Paludetti G. (ORCID:0000-0003-2480-1243), Galli J. (ORCID:0000-0001-6353-6249), Longobardi Y., Tricarico L., Buonsenso D., Valentini P. (ORCID:0000-0001-6095-9510), Sinatti D., De Rose C., Richeldi L. (ORCID:0000-0001-8594-1448), Calabrese A., Leone P. M., Intini E., Sani G. (ORCID:0000-0002-9767-8752), Janiri D., Simonetti A., Natale L. (ORCID:0000-0002-7949-5119), Larici A. R. (ORCID:0000-0002-1882-6244), Marano R. (ORCID:0000-0003-2710-2093), Petricca L., Gigante L., Fedele A. L., Lizzio M. M., Tolusso B. (ORCID:0000-0002-9108-6609), Di Mario C., Alivernini S. (ORCID:0000-0002-7383-4212), Santoliquido A. (ORCID:0000-0003-1539-4017), Popolla V., Galluzzo, Vincenzo, Zazzara, Maria Beatrice, Ciciarello, Francesca, Savera, Giulia, Pais, C., Calvani, Riccardo, Picca, A., Marzetti, Emanuele, Landi, Francesco, Tosato, Matteo, Steering, Committee, Gremese, Elisa, Coordination, Bernabei, Roberto, Fantoni, Massimo, Gasbarrini, Antonio, Field, Investigator, Gastroenterology, Team, Porcari, Serena, Settanni, Carlo Romano, Geriatric, Team, Benvenuto, F., Bramato, Giulia, Brandi, Vincenzo, Carfi, A., Fabrizi, Sofia, Lo Monaco, Maria Rita, Martone, Anna Maria, Napolitano, C., Pagano, Francesco Cosimo, Rocchi, Sara, Rota, E., Salerno, Andrea Maria, Tritto, M., Catalano, Lucio, Damiano, Francesco Paolo, Rocconi, Alessandra, Galliani, Alessandro, Spaziani, G., Tupputi, Salvatore, Cocchi, Camilla, Pirone, Flavia, D'Ignazio, F., Cacciatore, Stefano, Infectious disease, Team, Cauda, Roberto, Tamburrini, Enrica, Borghetti, Alberto, Di Gianbenedetto, S., Murri, Rita, Cingolani, Antonella, Ventura, Giulio, Taddei, E., Moschese, D., Ciccullo, A., Dusina, A., Internal Medicine, Team, Stella, L., Addolorato, Giovanni, Franceschi, Francesco, Mingrone, Geltrude, Zocco, Maria Assunta, Microbiology, Team, Sanguinetti, Maurizio, Cattani Franchi, Paola, Marchetti, Simona, Posteraro, Brunella, Sali, M., Neurology, Team, Bizzarro, Alessandra, Lauria, Alessandra, Ophthalmology, Team, Rizzo, Stanislao, Savastano, Maria Cristina, Gambini, Gloria, Cozzupoli, G. M., Culiersi, Carola, Otolaryngology, Team, Passali, Giulio Cesare, Paludetti, Gaetano, Galli, Jacopo, Crudo, F., Di Cintio, G., Longobardi, Ylenia, Tricarico, Laura, Santantonio, M., Pediatric, Team, Buonsenso, Danilo, Valentini, Piero, Pata, D., Sinatti, Dario, De Rose, Cristina, Pneumology, Team, Richeldi, Luca, Lombardi, F., Calabrese, Anna Chiara, Leone, Paolo Maria, Calvello, M. R., Intini, Enrica, Montemurro, G., Psychiatric, Team, Sani, Gabriele, Janiri, Delfina, Simonetti, Alessio, Giuseppin, G., Molinaro, M., Odica, M., Radiology, Team, Natale, Luigi, Larici, Anna Rita, Marano, Riccardo, Rheumatology, Team, Paglionico, A., Petricca, Luca, Gigante, Lavinia, Natalello, G., Fedele, Anna Laura, Lizzio, Marco Maria, Tolusso, Barbara, Di Mario, Clara, Alivernini, Stefano, Vascular, Team, Santoliquido, Angelo, Santoro, L., Di Giorgio, A., Nesci, A., Popolla, Valentina, Galluzzo V., Zazzara M. B., Ciciarello F., Savera G., Calvani R. (ORCID:0000-0001-5472-2365), Marzetti E. (ORCID:0000-0001-9567-6983), Landi F. (ORCID:0000-0002-3472-1389), Tosato M., Gremese E. (ORCID:0000-0002-2248-1058), Bernabei R. (ORCID:0000-0002-9197-004X), Fantoni M. (ORCID:0000-0001-6913-8460), Gasbarrini A. (ORCID:0000-0002-7278-4823), Porcari S., Settanni C. R., Bramato G., Brandi V., Fabrizi S., Lo Monaco M. R. (ORCID:0000-0002-1457-7981), Martone A. M., Pagano F. C., Rocchi S., Salerno A., Catalano L., Damiano F. P., Rocconi A., Galliani A., Tupputi S., Cocchi C., Pirone F., Cacciatore S., Cauda R. (ORCID:0000-0002-1498-4229), Tamburrini E. (ORCID:0000-0003-4930-426X), Borghetti A., Murri R. (ORCID:0000-0003-4263-7854), Cingolani A. (ORCID:0000-0002-3793-2755), Ventura G. (ORCID:0000-0002-0304-7264), Addolorato G. (ORCID:0000-0002-1522-9946), Franceschi F. (ORCID:0000-0001-6266-445X), Mingrone G. (ORCID:0000-0003-2021-528X), Zocco M. A. (ORCID:0000-0002-0814-9542), Sanguinetti M. (ORCID:0000-0002-9780-7059), Cattani P. (ORCID:0000-0003-4678-4763), Marchetti S., Posteraro B. (ORCID:0000-0002-1663-7546), Bizzarro A., Lauria A., Rizzo S. (ORCID:0000-0001-6302-063X), Savastano M. C. (ORCID:0000-0003-1397-4333), Gambini G., Culiersi C., Passali G. C. (ORCID:0000-0002-8176-0962), Paludetti G. (ORCID:0000-0003-2480-1243), Galli J. (ORCID:0000-0001-6353-6249), Longobardi Y., Tricarico L., Buonsenso D., Valentini P. (ORCID:0000-0001-6095-9510), Sinatti D., De Rose C., Richeldi L. (ORCID:0000-0001-8594-1448), Calabrese A., Leone P. M., Intini E., Sani G. (ORCID:0000-0002-9767-8752), Janiri D., Simonetti A., Natale L. (ORCID:0000-0002-7949-5119), Larici A. R. (ORCID:0000-0002-1882-6244), Marano R. (ORCID:0000-0003-2710-2093), Petricca L., Gigante L., Fedele A. L., Lizzio M. M., Tolusso B. (ORCID:0000-0002-9108-6609), Di Mario C., Alivernini S. (ORCID:0000-0002-7383-4212), Santoliquido A. (ORCID:0000-0003-1539-4017), and Popolla V.

Abstract

Background: Fatigue with reduced tolerance to exercise is a common persistent long-lasting feature amongst COVID-19 survivors. The assessment of muscle function in this category of patients is often neglected.Aim.: To evaluate the potential impact of a daily supplementation based on amino acids, minerals, vi-tamins, and plant extracts (Apportal (R)) on muscle function, body composition, laboratory parameters and self-rated health in a small group of COVID-19 survivors affected by fatigue.Methods: Thirty participants were enrolled among patients affected by physical fatigue during or after acute COVID-19 and admitted to the post-COVID-19 outpatient service at Fondazione Policlinico Gemelli in Rome between 1st March 2021 and 30th April 2021. All participants were evaluated at first visit (t0) and at control visit (t1), after taking a daily sachet of Apportal (R) for 28 days. Muscle function was analyzed using hand grip strength test, exhaustion strength time and the number of repetitions at one -minute chair stand test. Body composition was assessed with bioelectrical impedance analysis (BIA). Laboratory parameters, including standard blood biochemistry and ferritin levels, were evaluated at the first visit and during the control visit. A quick evaluation of self-rated health, before COVID-19, at t0 and t1, was obtained through a visual analogue scale (VAS). Results: Participants aged 60 years and older were 13 (43%). Females represented the 70% of the study sample. Participants hospitalized for COVID-19 with low -flow oxygen supplementation represented the 43.3% of the study sample while 3.3% received noninvasive ventilation (NIV) or invasive ventilation. Hand grip strength improved from 26.3 Kg to 28.9 Kg (p < 0.05) at t1 as compared to t0. The mean time of strength exhaustion increased from 31.7 s (sec) at t0 to 47.5 s at t1 (p < 0.05). Participants performed a higher number of repetitions (28.3 vs. 22.0; p < 0.05) during the one-minute chair stand test at

Published
2022

47. Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatigue in Adults with Long COVID: A Single-Blind Randomized Controlled Trial

Author

Tosato, Matteo, Calvani, Riccardo, Picca, A., Ciciarello, Francesca, Galluzzo, Vincenzo, Coelho-Junior, H. J., Di Giorgio, Angela, Di Mario, Clara, Gervasoni, Jacopo, Gremese, Elisa, Leone, Paolo Maria, Nesci, Antonio, Paglionico, A. M., Santoliquido, Angelo, Santoro, Luca, Santucci, Lavinia, Tolusso, Barbara, Urbani, Andrea, Marini, F., Marzetti, Emanuele, Landi, Francesco, Tosato M., Calvani R. (ORCID:0000-0001-5472-2365), Ciciarello F., Galluzzo V., Di Giorgio A., Di Mario C., Gervasoni J., Gremese E. (ORCID:0000-0002-2248-1058), Leone P. M., Nesci A., Santoliquido A. (ORCID:0000-0003-1539-4017), Santoro L., Santucci L., Tolusso B. (ORCID:0000-0002-9108-6609), Urbani A. (ORCID:0000-0001-9168-3174), Marzetti E. (ORCID:0000-0001-9567-6983), Landi F. (ORCID:0000-0002-3472-1389), Tosato, Matteo, Calvani, Riccardo, Picca, A., Ciciarello, Francesca, Galluzzo, Vincenzo, Coelho-Junior, H. J., Di Giorgio, Angela, Di Mario, Clara, Gervasoni, Jacopo, Gremese, Elisa, Leone, Paolo Maria, Nesci, Antonio, Paglionico, A. M., Santoliquido, Angelo, Santoro, Luca, Santucci, Lavinia, Tolusso, Barbara, Urbani, Andrea, Marini, F., Marzetti, Emanuele, Landi, Francesco, Tosato M., Calvani R. (ORCID:0000-0001-5472-2365), Ciciarello F., Galluzzo V., Di Giorgio A., Di Mario C., Gervasoni J., Gremese E. (ORCID:0000-0002-2248-1058), Leone P. M., Nesci A., Santoliquido A. (ORCID:0000-0003-1539-4017), Santoro L., Santucci L., Tolusso B. (ORCID:0000-0002-9108-6609), Urbani A. (ORCID:0000-0001-9168-3174), Marzetti E. (ORCID:0000-0001-9567-6983), and Landi F. (ORCID:0000-0002-3472-1389)

Abstract

Long COVID, a condition characterized by symptom and/or sign persistence following an acute COVID-19 episode, is associated with reduced physical performance and endothelial dysfunction. Supplementation of l-arginine may improve endothelial and muscle function by stimulating nitric oxide synthesis. A single-blind randomized, placebo-controlled trial was conducted in adults aged between 20 and 60 years with persistent fatigue attending a post-acute COVID-19 outpatient clinic. Participants were randomized 1:1 to receive twice-daily orally either a combination of 1.66 g l-arginine plus 500 mg liposomal vitamin C or a placebo for 28 days. The primary outcome was the distance walked on the 6 min walk test. Secondary outcomes were handgrip strength, flow-mediated dilation, and fatigue persistence. Fifty participants were randomized to receive either l-arginine plus vitamin C or a placebo. Forty-six participants (median (interquartile range) age 51 (14), 30 [65%] women), 23 per group, received the intervention to which they were allocated and completed the study. At 28 days, l-arginine plus vitamin C increased the 6 min walk distance (+30 (40.5) m; placebo: +0 (75) m, p = 0.001) and induced a greater improvement in handgrip strength (+3.4 (7.5) kg) compared with the placebo (+1 (6.6) kg, p = 0.03). The flow-mediated dilation was greater in the active group than in the placebo (14.3% (7.3) vs. 9.4% (5.8), p = 0.03). At 28 days, fatigue was reported by two participants in the active group (8.7%) and 21 in the placebo group (80.1%; p < 0.0001). l-arginine plus vitamin C supplementation improved walking performance, muscle strength, endothelial function, and fatigue in adults with long COVID. This supplement may, therefore, be considered to restore physical performance and relieve persistent symptoms in this patient population.

Published
2022

48. POS0777 STUDY OF PERIPHERAL BLOOD B CELL IMMUNO-PHENOTYPING IN PATIENTS WITH LUPUS NEPHRITIS: PARAMETERS OF DISEASE ACTIVITY, REMISSION AND FLARE

Author

Di Mario, C., primary, Varriano, V., additional, Petricca, L., additional, Paglionico, A., additional, Gigante, M. R., additional, Costanzi, S., additional, Bui, L., additional, Federico, F., additional, D’agostino, M. A., additional, Alivernini, S., additional, Tolusso, B., additional, and Gremese, E., additional

Published
2022
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50. POS0105 IMMUNOLOGICAL AND TISSUE DERIVED BIOMARKERS OF EARLY RESPONSE IN MODERATE-TO-SEVERE RHEUMATOID ARTHRITIS TREATED WITH JAK-INHIBITORS

Author

Perniola, S., primary, Tolusso, B., additional, DI Mario, C., additional, Gessi, M., additional, Bruno, D., additional, Varriano, V., additional, Paglionico, A., additional, Petricca, L., additional, Gigante, M. R., additional, D’agostino, M. A., additional, Alivernini, S., additional, and Gremese, E., additional

Published
2022
Full Text
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