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267 results on '"DI BONITO, LUIGI"'

1. A Domain Specific Language for the Design of Artificial Intelligence Applications for Process Engineering

Author

Campanile, Lelio, Di Bonito, Luigi Piero, Gribaudo, Marco, Iacono, Mauro, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin, Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Hyytiä, Esa, editor, and Kavitha, Veeraruna, editor

Published
2023
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4. The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology: Introduction and Overview

Author

Field, Andrew S., Raymond, Wendy A., Rickard, Mary T., Arnold, Lauren, Brachtel, Elena F., Chaiwun, Benjaporn, Chen, Lan, Chong, P. Y., Di Bonito, Luigi, Hoda, Rana S., Kurtycz, Daniel F. I., Lee, Andrew H. S., Lim, Elgene, Ljung, Britt-Marie, Michelow, Pamela, Osamura, Robert Y., Pinamonti, Maurizio, Sauer, Torill, Segara, Davendra, Tse, Gary M., Vielh, Philippe, Schmitt, Fernando, Field, Andrew S., editor, Raymond, Wendy A., editor, and Schmitt, Fernando, editor

Published
2020
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5. Benign

Author

Field, Andrew S., Di Bonito, Luigi, Pinamonti, Maurizio, Michelow, Pamela, Raymond, Wendy A., Sauer, Torill, Lee, Andrew H. S., Rickard, Mary T., Arnold, Lauren, Geddie, William R., Schmitt, Fernando, Field, Andrew S., editor, Raymond, Wendy A., editor, and Schmitt, Fernando, editor

Published
2020
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10. Diagnostic accuracy of Hybrid Capture 2 test: Results obtained from internal quality control

Author

PINAMONTI, MAURIZIO, DOBRIĆ, JELENA, ISIDORO, ERICA, ROZZE, DAVIDE, WIESENFELD, URI, GIUDICI, FABIOLA, ULCIGRAI, LORENA, VARIOLA, FRANCESCA, ROMANO, ANDREA, DUDINE, SANDRA, COPPOLA, NORA, DI BONITO, LUIGI, ZANCONATI, FABRIZIO, Renda, V., Bertolini, S., Gerin, D., Biagi, C., Di Napoli, M., Franzo, A., Gongolo, F., Pinamonti, Maurizio, Dobrić, Jelena, Isidoro, Erica, Rozze, Davide, Renda, V., Wiesenfeld, Uri, Giudici, Fabiola, Bertolini, S., Gerin, D., Biagi, C., Ulcigrai, Lorena, Variola, Francesca, Di Napoli, M., Romano, Andrea, Dudine, Sandra, Franzo, A., Gongolo, F., Coppola, Nora, DI BONITO, Luigi, and Zanconati, Fabrizio

Subjects
Objectives. We studied the association between placentas histomorphometry in gestational diabetes mellitus (GDM) and race/ethnicity. Methods. We collected a total amount of 412 placentas, 292 where from Pordenone Hospital and 120 where from Monselice Hospital. Of the 412 placentas specimens, 146 had a clinical or sub-clinical diagnosis of GDM (110 from Pordenone and 36 from Monselice). Results. Placentas of non-Caucasian women without GDM where (27%) whereas placentas with GDM where (34%). In contrast with literature, our data showed an higher incidence of GDM among Caucasian than non-Caucasian women. Conclusions. Studies so far published indicated that GDM in placentas of non-Caucasian ethnicity has ahigher incidence, yet results of our investigation shows an opposite trend. Further investigations are in progress to better define the reason of these conflicting data. [Objectives. We studied the association between placentas histomorphometry in gestational diabetes mellitus (GDM) and race/ethnicity. Methods. We collected a total amount of 412 placentas, from singleton full-term live births, from January 2015 till June 2016 (18 months)], Objectives. We studied the association between placentas histomorphometry in gestational diabetes mellitus (GDM) and race/ethnicity. Methods. We collected a total amount of 412 placentas, from singleton full-term live births, from January 2015 till June 2016 (18 months): 292 where from Pordenone Hospital and 120 where from Monselice Hospital. Of the 412 placentas specimens, 146 had a clinical or sub-clinical diagnosis of GDM (110 from Pordenone and 36 from Monselice). Results. Placentas of non-Caucasian women without GDM where (27%) whereas placentas with GDM where (34%). In contrast with literature, our data showed an higher incidence of GDM among Caucasian than non-Caucasian women. Conclusions. Studies so far published indicated that GDM in placentas of non-Caucasian ethnicity has ahigher incidence, yet results of our investigation shows an opposite trend. Further investigations are in progress to better define the reason of these conflicting data, yet results of our investigation shows an opposite trend. Further investigations are in progress to better define the reason of these conflicting data, our data showed an higher incidence of GDM among Caucasian than non-Caucasian women. Conclusions. Studies so far published indicated that GDM in placentas of non-Caucasian ethnicity has ahigher incidence, from singleton full-term live births, from January 2015 till June 2016 (18 months): 292 where from Pordenone Hospital and 120 where from Monselice Hospital. Of the 412 placentas specimens, 146 had a clinical or sub-clinical diagnosis of GDM (110 from Pordenone and 36 from Monselice). Results. Placentas of non-Caucasian women without GDM where (27%) whereas placentas with GDM where (34%). In contrast with literature
Published
2016

11. The International Academy of Cytology Yokohama System for Reporting Breast Fine-Needle Aspiration Biopsy Cytopathology

Author

Field, Andrew S., primary, Raymond, Wendy A., additional, Rickard, Mary, additional, Arnold, Lauren, additional, Brachtel, Elena F., additional, Chaiwun, Benjaporn, additional, Chen, Lan, additional, Di Bonito, Luigi, additional, Kurtycz, Daniel F.I., additional, Lee, Andrew H.S., additional, Lim, Elgene, additional, Ljung, Britt-Marie, additional, Michelow, Pamela M., additional, Osamura, Robert Y., additional, Pinamonti, Maurizio , additional, Sauer, Torill, additional, Segara, Davendra, additional, Tse, Gary, additional, Vielh, Philippe, additional, Chong, Phek Y., additional, and Schmitt, Fernando, additional

Published
2019
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12. Cervical cancer screening in Mediterranean countries: implicatios for the future

Author

Syrjanen K., Gonçalves L., Murjal L., Santamaria M., Mahovlic V., Karakitsos P., Onal B., Schmitt F. C., DI BONITO, LUIGI, Syrjanen, K., DI BONITO, Luigi, Gonçalves, L., Murjal, L., Santamaria, M., Mahovlic, V., Karakitsos, P., Onal, B., and Schmitt, F. C.

Subjects
Cervical cancer screening
Published
2012

13. ASC-US: triage with HPV test

Author

Isidoro, E., Di Napoli, M., Romano, A., Giudici, Fabiola, Nicastro, E., Brollo, A., Bottin, Cristina, DI BONITO, Luigi, Zanconati, Fabrizio, Bonifacio, Daniela, Isidoro, E., Di Napoli, M., Romano, A., Giudici, Fabiola, Nicastro, E., Brollo, A., Bottin, Cristina, DI BONITO, Luigi, Zanconati, Fabrizio, and Bonifacio, Daniela

Subjects
cervical cancer, hpv test
Abstract

The category ASC-US continues to be controversial despite strict criteria laid down by the Bethesda 2011 Committee,as it does not have a histological counterpart and it refers to cythological findings that may or may not be associated with a significant epithelial lesion of the cervix. The proportion of CIN2+ is very low among women with an ASC-US diagnosis, so identification of those at higher risk would be clinically useful. In this study we analysed ASC-US cases of Trieste and Gorizia diagnosed in the period 2009-2011 to evaluate the presence/absence of lesions in the histological follow-up in women HR-HPV positives.

Published
2012

14. Role of lifestyles in breast cancer risk: a retrospective analysis of Trieste's female population

Author

GIUDICI, FABIOLA, BOTTIN, CRISTINA, BIANCO, Alberto, DI BONITO, LUIGI, ZANCONATI, FABRIZIO, COVA, MARIA ASSUNTA, BORTUL, MARINA, ARNEZ, ZORAN MARIJ, MUSTACCHI, GIORGIO, TORELLI, LUCIO, De Martino S., Martellani F., Ober E., Romano A., Zacchi A., Tonutti m., Gasparini C., Assante M., Frezza F., Bortolotto M. P., Cressa C., Perrone R., Makuc E., Petz G., de Morpurgo P. L., Pellis G., Lizza N., Scomersi S., Dell'Antonio A., Convertino C., Borea B., Renzi N., Dellach C., Franzo A., Zanier L., Giudici, Fabiola, De Martino, S., Bottin, Cristina, Bianco, Alberto, DI BONITO, Luigi, Martellani, F., Ober, E., Romano, A., Zacchi, A., Zanconati, Fabrizio, Cova, MARIA ASSUNTA, Tonutti, M., Gasparini, C., Assante, M., Frezza, F., Bortolotto, M. P., Cressa, C., Perrone, R., Makuc, E., Petz, G., de Morpurgo, P. L., Pellis, G., Lizza, N., Bortul, Marina, Scomersi, S., Dell'Antonio, A., Convertino, C., Borea, B., Renzi, N., Arnez, ZORAN MARIJ, Dellach, C., Mustacchi, Giorgio, Franzo, A., Zanier, L., and Torelli, Lucio

Subjects
bmi, breast cancer, risk factor, breast screening program, smoking risk
Abstract

Friuli Venezia Giulia holds the higest row incidence rate for breast carcinoma in Italy (218%00) and Trieste, where live 125.000 women (105.000 women of age below 75) has the highest incidence rate among the other provinces of the region (220%00). The risk of developing breast carcinoma seems to be correlated with many different factors. The goal of this study is to focus on same specific breast carcinoma risk factors in the Trieste population.

Published
2012

15. Cyto-radiological disageement: management

Author

Zanconati, Fabrizio, Giudici, Fabiola, Bianco, Alberto, Bonifacio, Daniela, Bottin, Cristina, Dudine, S., Martellani, F., Ober, E., Romano, A., Zacchi, A., Pinamonti, Maurizio, Zandonà, L., AL OMOUSH, Tahseen, Tonutti, M., Bortul, Marina, Assante, A., Cova, MARIA ASSUNTA, Gasparini, C., Frezza, F., Bortolotto, M. P., Cressa, C., Perrone, R., Makuc, E., Petz, G., de Morpurgo, P. L., Torelli, Lucio, DI BONITO, Luigi, Zanconati, Fabrizio, Giudici, Fabiola, Bianco, Alberto, Bonifacio, Daniela, Bottin, Cristina, Dudine, S., Martellani, F., Ober, E., Romano, A., Zacchi, A., Pinamonti, Maurizio, Zandonà, L., AL OMOUSH, Tahseen, Tonutti, M., Bortul, Marina, Assante, A., Cova, MARIA ASSUNTA, Gasparini, C., Frezza, F., Bortolotto, M. P., Cressa, C., Perrone, R., Makuc, E., Petz, G., de Morpurgo, P. L., Torelli, Lucio, and DI BONITO, Luigi

Subjects
cyto-radiological correlation, breast cytology, diagnostic category, quality control, cyto-histological correlation
Abstract

In Trieste, pathologists have been actively involved in breast diagnostics working alongside radiologists in the sampling time in order to set up together the most adequate approach in case-solving basing on the clinical/radiological and rapid stain cytological findings. Based on our own experience we prefer, whenever possible, to use the fine needle aspiration sampling method (FNA), almost always under ultrasound guidance, even for palpable lesions, reserving tru-cut biopsy only for a limited number of cases and vacuum-assisted biopsy (VAB) only in not ultrasound detectable lesions (id: isolated microcalcifications). The collaboration between radiologist and pathologist is essential to correctly evaluate identified lesions: the more coincident the results of radiological and cytological exams are, the more accurate the final diagnosis will be. Nevertheless there are some cases in which radiology and cytology do not agree. We decided to reassess the entire database, focusing on the management of discrepant cases in the light of the final histological diagnosis for surgical-treated cases or referring to the follow-up exams in the cases that did not undergo surgery.

Published
2012

16. Breast FNAC in Mammografic Screening Program of Trieste,Italy

Author

Zanconati, Fabrizio, Romano, A., Martellani, F., Ober, E., Giudici, Fabiola, Pinamonti, Maurizio, Bonifacio, Daniela, Bottin, Cristina, Tonutti, M., Bortul, Marina, Zacchi, A., Zandona', L., AL OMOUSH, Tahseen, Torelli, Lucio, DI BONITO, Luigi, Zanconati, Fabrizio, A., Romano, F., Martellani, E., Ober, Giudici, Fabiola, Pinamonti, Maurizio, Bonifacio, Daniela, Bottin, Cristina, M., Tonutti, Bortul, Marina, A., Zacchi, L., Zandona', AL OMOUSH, Tahseen, Torelli, Lucio, and DI BONITO, Luigi

Subjects
breast cancer, mammografic screening program, fine needle aspiration
Abstract

Breast cancer is thecmost frequency malignancy in women in the world and also in Italy.In Trieste most of breast lesions are investigated by fine needle aspiration cytology under ultrasound guidance (FNAC). Tru-cut is used when FNAC is inadequate, for discrepancy with radiology or to have a biomolecular profiling,expecially in neoadjuvant chemotherapy. Vacuum Aspiration Biopsy (VAB) is used in case of microcalcifications or mammographic abnormalitues without evidence of nodules.FNAC's goal is to define breast lesions avoiding more invasive procedures,, it provides several benefits for women, for pathologists and for the public health

Published
2012

17. Breast citology fine needle aspiration

Author

DI BONITO, Luigi, Martellani, F., Romano, A., Zacchi, A., Ober, E., DE PELLEGRIN, Alessandro, Bonifacio, Daniela, Giudici, Fabiola, Torelli, Lucio, Zanconati, Fabrizio, DI BONITO, Luigi, Martellani, F., Romano, A., Zacchi, A., Ober, E., DE PELLEGRIN, Alessandro, Bonifacio, Daniela, Giudici, Fabiola, Torelli, Lucio, and Zanconati, Fabrizio

Subjects
breast citology, statistic methods
Published
2011

18. Prognostic-predictive factors in breast cancer: comparison of mRNA level (Target Print) and immunohistochemistry expression

Author

Zandonà L., De Pellegrin A., Ober E., Zacchi A., Martellani F., Romano A., Leonardo E., Pellis G., Dell'Antonio A., Convertino C., AL OMOUSH, TAHSEEN, GIUDICI, FABIOLA, BORTUL, MARINA, MUSTACCHI, GIORGIO, TORELLI, LUCIO, DI BONITO, LUIGI, ZANCONATI, FABRIZIO, Zandonà, L., De Pellegrin, A., Ober, E., Zacchi, A., Martellani, F., Romano, A., Leonardo, E., AL OMOUSH, Tahseen, Giudici, Fabiola, Bortul, Marina, Pellis, G., Dell'Antonio, A., Mustacchi, Giorgio, Torelli, Lucio, Convertino, C., DI BONITO, Luigi, and Zanconati, Fabrizio

Subjects
breast cancer, Immonohistochemistry, HER2, target print
Abstract

Target Print (TP) is a microarray-based gene expression test which offers a quantitative assessment of the patient'slevel of estrogen receptor (ER), progesterone receptor (PR) and HER2/neu overexpression within her breast cancer. As compared to Immunohistochemistry (IHC), TP delivers an added benefit to the diagnostic process. IHC provide a semi-quantitative positive or negative result, whereas the gene expression result provided by TP allows to integrate the absolute level of ER, PR and HER2 gene expression into treatment planning. It is known that differences in tissue fixation, choice of antibody and interpretation can severely affect IHC accuracy and reproducibility.

Published
2011

21. Breast cytology: reporting

Author

DI BONITO, LUIGI, BONIFACIO, DANIELA, AL OMOUSH, TAHSEEN, BONAZZA, DEBORAH, DE PELLEGRIN, ALESSANDRO, GIUDICI, FABIOLA, TORELLI, LUCIO, BORTUL, MARINA, ZANCONATI, FABRIZIO, Martellani F., Dudine S., Di Napoli M., Isidoro E., Ober E., Leonardo E., Romano A., Zacchi A., Haxhijmeri O., Petris M., Zandonà L., Bandiera V., Tonutti M., DI BONITO, Luigi, Martellani, F., Bonifacio, Daniela, Dudine, S., Di Napoli, M., Isidoro, E., Ober, E., Leonardo, E., Romano, A., Zacchi, A., AL OMOUSH, Tahseen, Bonazza, Deborah, DE PELLEGRIN, Alessandro, Haxhijmeri, O., Petris, M., Zandonà, L., Bandiera, V., Giudici, Fabiola, Torelli, Lucio, Bortul, Marina, Tonutti, M., and Zanconati, Fabrizio

Subjects
fine needle aspiration, breast lesions, diagnostic categories C1-C5, breast lesion
Abstract

Fine needle aspiration cytology (FNAC) is widely used as first choice approach for the definition of the radiologically dubious or sospicious cases to confim their benign origin. Trieste's Breast Unit has been using FNAC as first morphological investigation for many years, in particular in 2008-2009, it was used as first diagnostic approach for 1835 cases (88.6%) out of 2091. The use of five diagnostic categories in cytology reporting has found wide acceptance among radiologists and surgeons, because it allows to apply to each lesiod, a precise diagnostic/terapeutic pathway and it represents, in oir experience, an essential element of the report itself.

Published
2010

22. FNA's diagnostic role after the beginninig of breast screening program: experience of the Breast Unit (B.U.) in Trieste

Author

Petris, M., Martellani, F., Ober, E., Giudici, Fabiola, Zacchi, A., Torelli, Lucio, Bonifacio, Daniela, Romano, A., Tonutti, M., DI BONITO, Luigi, Petris, M., Martellani, F., Ober, E., Giudici, Fabiola, Zacchi, A., Torelli, Lucio, Bonifacio, Daniela, Romano, A., Tonutti, M., and DI BONITO, Luigi

Subjects
breast cancer, fine needle aspiration, screening program
Published
2010

23. Role of ultrasound (US)-guided FNA of axillary lymph nodes in breast carcinoma screening detected. P363

Author

Zanconati, Fabrizio, Tonutti, F., Martellani, F., Bortul, Marina, Contessa, N., Dore, F., De Pellegrin, A., Di Napoli, M., Dudine, S., Haxhiymeri, O., Isidoro, E., Pellis, G., Romano, A., Sarcinella, D., Schiavon, I., Zacchi, A., DI BONITO, Luigi, Zanconati, Fabrizio, Tonutti, F., Martellani, F., Bortul, Marina, Contessa, N., Dore, F., De Pellegrin, A., Di Napoli, M., Dudine, S., Haxhiymeri, O., Isidoro, E., Pellis, G., Romano, A., Sarcinella, D., Schiavon, I., Zacchi, A., and DI BONITO, Luigi

Subjects
sentinel lymph node, Breast cancer screening, sentinel lymph nodes, FNA cytology
Abstract

Breast carcinoma's screening in Trieste's area detected 60 women with cancer (two of them with bilateral cisease) in 2008. Forty-eight cases were diagnosed only by FNA (C5), 12 by VAB/mammotome and two by Fine Needle biopsy after undeterminated cytology. Axillary lymph nodes US was performed in 62,9% (39) of cases. They had alle been diagnosed as malignant (C5) by rapid cytology during breast nodule aspiration. .... Our study outlines cyology's accuracy to define axillary nodes' status suggestin the possibility to extent US followed by aspiration cytology to all screening detected cases with U3/4 axillary nodes.

Published
2009

24. Breast cytology diagnostic role in the screening program

Author

DI BONITO, LUIGI, BONIFACIO, DANIELA, GIUDICI, FABIOLA, TORELLI, LUCIO, ZANCONATI, FABRIZIO, HAXHIYMERI O, MARTELLANI F, ROMANO A, DUDINE, DI NAPOLI M, ISIDORO E, LEONARDO E, ZACCHI A, TONUTTI M, FRANZO A, DI BONITO, Luigi, Haxhiymeri, O, Martellani, F, Bonifacio, Daniela, Romano, A, Dudine, DI NAPOLI, M, Isidoro, E, Leonardo, E, Zacchi, A, Tonutti, M, Franzo, A, Giudici, Fabiola, Torelli, Lucio, and Zanconati, Fabrizio

Subjects
breast cancer, fine needle aspiration, screening program
Published
2009

25. Effects of Mammographic screening in Trieste (Italy) at the end of first round

Author

ZANCONATI, FABRIZIO, BONIFACIO, DANIELA, GIUDICI, FABIOLA, DI BONITO, LUIGI, Haxhiymeri O., Martellani F., Romano A., Leonardo E., De Pellegrin A., Zacchi A., Bandiera V., Franzo A., Tonutti M., Zanconati, Fabrizio, Haxhiymeri, O., Martellani, F., Romano, A., Bonifacio, Daniela, Leonardo, E., De Pellegrin, A., Zacchi, A., Bandiera, V., Giudici, Fabiola, Franzo, A., Tonutti, M., and DI BONITO, Luigi

Subjects
breast cancer, program of mammographic screening
Abstract

Trieste is one of the italian areas with the highest incidence of breast carcinoma. Mammographical screening has been active since 2006 inolving womenn 50-69 years old. Breast screening introduction has been led to an increase both of Tis lesions and of invasive carcinoma. The oserved growth is due to increase of subclinical lesions (T1a and T1b), while lesions larger than 2 cm maintained steady.

Published
2009

26. Sharing experience in serous fluid cytopathology: progress of the E-sc@n network project

Author

Piaton, E, Bondi, A, DI BONITO, Luigi, Bubendorf, L, Cochand Priollet, B, Davidson, B, Garbar, C, Hofman, V, Ayala B, J. i. m. e. n. e. z., Glatz, K, Maurice, C, Plazy, M, Schmitt, F, Toetsch, M, Villeneuve, L, Vielh, P., Piaton, E, Bondi, A, DI BONITO, Luigi, Bubendorf, L, Cochand Priollet, B, Davidson, B, Garbar, C, Hofman, V, Ayala B, J. i. m. e. n. e. z., Glatz, K, Maurice, C, Plazy, M, Schmitt, F, Toetsch, M, Villeneuve, L, and Vielh, P.

Subjects
Serous effusions, cytopathology, Serous effusion
Published
2009

27. Breast Cytology

Author

DI BONITO, Luigi, Bonifacio, Daniela, Dudine, S., Leonardo, E., Martellani, F., Romano, A., Tonutti, M., Zacchi, A., Zanconati, Fabrizio, DI BONITO, Luigi, Bonifacio, Daniela, Dudine, S., Leonardo, E., Martellani, F., Romano, A., Tonutti, M., Zacchi, A., and Zanconati, Fabrizio

Subjects
breast cancer, fine needle aspiration, screening-program
Published
2009

28. C1-C5 in breast cytology

Author

ZANCONATI, FABRIZIO, BONIFACIO, DANIELA, GIUDICI, FABIOLA, TORELLI, LUCIO, DI BONITO, LUIGI, DE PELLEGRIN A, DI NAPOLI M, ISIDORO E, MARTELLANI F, ROMANO A, ULCIGRAI L, TONUTTI M, ZACCHI A, Zanconati, Fabrizio, Bonifacio, Daniela, DE PELLEGRIN, A, DI NAPOLI, M, Giudici, Fabiola, Isidoro, E, Martellani, F, Romano, A, Ulcigrai, L, Tonutti, M, Torelli, Lucio, Zacchi, A, and DI BONITO, Luigi

Subjects
breast cancer, fine needle aspiration, diagnostic categories
Published
2009

29. Clinical significance of ASC-H in non menopausal, perimenopausal and postmenopausal women

Author

Di Napoli, M., Zanconati, Fabrizio, Isidoro, E., Bonifacio, Daniela, De Pellegrin, A., Dudine, S. Leonardo E., Romano, A., Sarcinella, D., Schiavon, I., DI BONITO, Luigi, Di Napoli, M., Zanconati, Fabrizio, Isidoro, E., Bonifacio, Daniela, De Pellegrin, A., Dudine, S. Leonardo E., Romano, A., Sarcinella, D., Schiavon, I., and DI BONITO, Luigi

Subjects
cervical cancer screening, ASC-H, menopausal status
Abstract

Our study

Published
2009

31. Rolo of ultrasound (US)-guided FNA of axillary lymph nodes in breast carcinoma screening detected

Author

ZANCONATI, FABRIZIO, BORTUL, MARINA, DORE, FRANCA, DI BONITO, LUIGI, TONUTTI M, MARTELLANI F, CONTESSA N, DE PELLEGRIN A, DI NAPOLI M, DUDINE S, HAXHIYMERI O, ISIDORO E, PELLIS G, ROMANO A, SARCINELLA D, SCHIAVON I, ZACCHI A, Zanconati, Fabrizio, Tonutti, M, Martellani, F, Bortul, Marina, Contessa, N, Dore, Franca, DE PELLEGRIN, A, DI NAPOLI, M, Dudine, S, Haxhiymeri, O, Isidoro, E, Pellis, G, Romano, A, Sarcinella, D, Schiavon, I, Zacchi, A, and DI BONITO, Luigi

Subjects
fine needle aspiration, breast carcinoma, axillary limph
Published
2009

32. An unusual case of 'C3' FNA of breast screening detected lesion with cytohistological and immunohistochemical correlaion

Author

Zanconati, Fabrizio, Leonardo, E., Martellani, F., Haxhiymeri, O., Bonifacio, Daniela, Dudine, S., Romano, A., Neves, B., Pellis, G., Zacchi, A., Tonutti, M., DI BONITO, Luigi, Zanconati, Fabrizio, Leonardo, E., Martellani, F., Haxhiymeri, O., Bonifacio, Daniela, Dudine, S., Romano, A., Neves, B., Pellis, G., Zacchi, A., Tonutti, M., and DI BONITO, Luigi

Subjects
brest screening program, breast cancer, immunohistochemestry
Abstract

Accordin to the guidelines ofBreast Unit of Trieste's Province (Italy) all the mammographic abnormalities and lesions with clinical symptoms must be submitted to echography and in presenc of a doubtful finiding they must be investigated with fine needle Aspiration (FNA)under ultrasound guidance. Core or aspiation biopsy is reserved instead for those cases with inconclusive (C3-C4)

Published
2009

33. Cito-histological correlation of ASC-H in five years period

Author

Zanconati, Fabrizio, Isidoro, E., Di Napoli, M., Dudine, S., Martellani, F., Romano, A., Rosano, I., Slatich, G., Ulcigrai, L., Zacchi, A., DI BONITO, Luigi, Zanconati, Fabrizio, Isidoro, E., Di Napoli, M., Dudine, S., Martellani, F., Romano, A., Rosano, I., Slatich, G., Ulcigrai, L., Zacchi, A., and DI BONITO, Luigi

Subjects
H-SIL, Cervical cancer screening Bethesda system, cytohistological correlatio
Abstract

Incidence of ASC-H has been reported to be 0.13-0,84% and SIL on follow-up biopsy ranged from 27 to 89%. This diagnosis is used for cases that show cellular abnormalities more marked than reactive changes but that fall short of a definitive diagnosis of HSIL. We used cyto histologic correlation to determe the clinical significance of ASC-H fron 2004 to 2008.Out of 77 709 Pap smears, 182 were ASC-H (0,23%). ....... The diagnosis of ASC-H is associatd with an appreciable risk of lesion, so the patiensts should undergo colposcopic and histologic assessment to toule out SIL. Negative biopsy review outlined doubtful cases were mainly squamous metaplasia.

Published
2009

34. Iter diagnostico nella definizione delle lesioni mammarie: esperienza dell'Unità Senologica Interaziendale di Trieste

Author

Zanconati, Fabrizio, Haxhiymeri, O., Martellani, F., Romano, A., Bonifacio, Daniela, Bandiera, V., Giudici, Fabiola, Torelli, Lucio, Tonutti, Maura, Perrone, R., Frezza, F., Cressa, C., Assante, M., Bortolotto, P., Borea, B., Bortul, Marina, Dell'Antonio, A., Pellis, G., Franzo, A., Dellach, C., DI BONITO, Luigi, Zanconati, Fabrizio, Haxhiymeri, O., Martellani, F., Romano, A., Bonifacio, Daniela, Bandiera, V., Giudici, Fabiola, Torelli, Lucio, Tonutti, Maura, Perrone, R., Frezza, F., Cressa, C., Assante, M., Bortolotto, P., Borea, B., Bortul, Marina, Dell'Antonio, A., Pellis, G., Franzo, A., Dellach, C., and DI BONITO, Luigi

Subjects
lesioni mammarie, test diagnostici, interdisciplinarietà
Published
2009

35. Ruolo della citologia nel programma di screening mammografico

Author

DI BONITO, LUIGI, BONIFACIO, DANIELA, ZANCONATI, FABRIZIO, DUDINE S, LEONARDO E, MARTELLANI F, ROMANO A, TONUTTI M, TORELLI, LUCIO, DI BONITO, Luigi, Bonifacio, Daniela, Dudine, S, Leonardo, E, Martellani, F, Romano, A, Tonutti, M, Torelli, Lucio, and Zanconati, Fabrizio

Published
2008

36. Considerazioni sul rapporto costo/beneficio del protocollo istologico del linfonodo sentinella nello screening mammografico

Author

DE PELLEGRIN, A, Zanconati, Fabrizio, Bortul, M, Dell'Antonio, A, Borea, B, Pellis, G, Dore, F, Tonutti, M, Bonifacio, Daniela, Contessa, N, DI NAPOLI, M, Dudine, S, Sarcinella, D, Schiavon, I, Ober, E, Zacchi, A, DI BONITO, Luigi, DE PELLEGRIN, A, Zanconati, Fabrizio, Bortul, M, Dell'Antonio, A, Borea, B, Pellis, G, Dore, F, Tonutti, M, Bonifacio, Daniela, Contessa, N, DI NAPOLI, M, Dudine, S, Sarcinella, D, Schiavon, I, Ober, E, Zacchi, A, and DI BONITO, Luigi

Published
2008

37. Deciduosi linfonodale ed ovarica versus metastasi di adenocarcinoma endocervicale in donna in gravidanza

Author

Zacchi, A., Bonifacio, Daniela, DE PELLEGRIN, Alessandro, Di Napoli, M., Isidoro, E., Leonardo, E., Martellani, F., Ober, E., Romano, A., Zanconati, Fabrizio, Nogales, F., DI BONITO, Luigi, Zacchi, A., Bonifacio, Daniela, DE PELLEGRIN, Alessandro, Di Napoli, M., Isidoro, E., Leonardo, E., Martellani, F., Ober, E., Romano, A., Zanconati, Fabrizio, Nogales, F., and DI BONITO, Luigi

Subjects
adenocarcinoma cervicale, metastasi
Published
2008

38. Unditermined lesions (C3 and C4) in breast cancer screening programme and in daily routine

Author

ZANCONATI, FABRIZIO, BONIFACIO, DANIELA, DI BONITO, LUIGI, CONTESSA N, DI NAPOLI M, DUDINE S, ISIDORO E, MARTELLANI F, OBER E, ROMANO A, SARCINELLA D, SCHIAVON I, SLATICH G, ULCIGRAI L, ZACCHI A, Zanconati, Fabrizio, Bonifacio, Daniela, Contessa, N, DI NAPOLI, M, Dudine, S, Isidoro, E, Martellani, F, Ober, E, Romano, A, Sarcinella, D, Schiavon, I, Slatich, G, Ulcigrai, L, Zacchi, A, and DI BONITO, Luigi

Subjects
sospicious lesions C3-C4, brest cancer, fine needle aspiration
Abstract

C3 and C4 represent the grey zone of breast aspiration cytology; we performed a comparison between C3 and C4 cases detected in 1314 consecutiva patients undergoing fine-needle aspiration cytology in the last 2 years.

Published
2008

39. Ruolo della citologia agoaspirativa nella definizione delle tumefazioni sovraclaveari

Author

Ober, E, Bonifacio, Daniela, Contessa, N, DE PELLEGRIN, Alessandro, DI NAPOLI, M, Dudine, S, Isidoro, E, Leonardo, E, Martellani, F, Romano, A, Rosano, I, Sarcinella, D, Schiavon, I, Slatich, G, Zacchi, A, Zanconati, Fabrizio, DI BONITO, Luigi, Ober, E, Bonifacio, Daniela, Contessa, N, DE PELLEGRIN, Alessandro, DI NAPOLI, M, Dudine, S, Isidoro, E, Leonardo, E, Martellani, F, Romano, A, Rosano, I, Sarcinella, D, Schiavon, I, Slatich, G, Zacchi, A, Zanconati, Fabrizio, and DI BONITO, Luigi

Subjects
citologia agoaspirativa, tumefazioni sovraclaveari, diagnosi
Published
2008

40. Immunocytochemistry's role in detecting primary tumor site of malignant effusions

Author

DI BONITO, LUIGI, ZANCONATI, FABRIZIO, BONIFACIO, DANIELA, LEONARDO E, ROMANO A, DUDINE S, DI BONITO, Luigi, Leonardo, E, Zanconati, Fabrizio, Romano, A, Dudine, S, and Bonifacio, Daniela

Subjects
immunohistochemistry, malignant effusions
Abstract

Neoplastic cells detection in effusions is extremely important as this may give information regarding primary tumor site, when unknown, for cancer staging and for cancer recurrence in the follow-up of oncologic patients

Published
2008

41. Classificazione NMH in citologia tiroidea: contributo ad una migliore definizione delle lesioni dubbie

Author

Zanconati, Fabrizio, Romano, A, Sabato, N, Bonifacio, Daniela, Dudine, S, DI NAPOLI, M, Isidoro, E, Rosano, I, Slatich, G, Ulcigrai, L, Martellani, F, DI BONITO, Luigi, Zanconati, Fabrizio, Romano, A, Sabato, N, Bonifacio, Daniela, Dudine, S, DI NAPOLI, M, Isidoro, E, Rosano, I, Slatich, G, Ulcigrai, L, Martellani, F, and DI BONITO, Luigi

Subjects
Fine-needle aspiration, citologia, lesioni tiroidee, classificazione
Published
2007

42. Indicatori surrogati di possibile amplificazione di HER-2/neu nel carcinoma mammario in assenza di immunoreattività

Author

Zanconati, Fabrizio, Bonifacio, Daniela, Dudine, S, Schiavon, I, Romano, A, Martellani, F, Sarcinella, D, Ober, E, DE PELLEGRIN, A, DI BONITO, Luigi, Zanconati, Fabrizio, Bonifacio, Daniela, Dudine, S, Schiavon, I, Romano, A, Martellani, F, Sarcinella, D, Ober, E, DE PELLEGRIN, A, and DI BONITO, Luigi

Subjects
FISH, Her-2, Carcinoma mammario, immunoistochimica
Published
2007

43. Contributo integrato della FNA e della microbiopsia mammaria nella gestione delle donne con anomalie rilevate in corso di screening mammografico: l'esperienza nel 2006 a Trieste

Author

ZANCONATI, FABRIZIO, BONIFACIO, DANIELA, DI BONITO, LUIGI, DI NAPOLI M, DUDINE S, FREZZA F, GASPARINI C, ISIDORO E, MARTELLANI F, ROMANO A, SARCINELLA D, SCHIAVON I, ULCIGRAI L, TONUTTI M, Zanconati, Fabrizio, Bonifacio, Daniela, DI NAPOLI, M, Dudine, S, Frezza, F, Gasparini, C, Isidoro, E, Martellani, F, Romano, A, Sarcinella, D, Schiavon, I, Ulcigrai, L, Tonutti, M, and DI BONITO, Luigi

Subjects
Fine-needle aspiration, lesioni mammarie, screening mammografico
Published
2007

45. Upregulation of nuclear factor-kappaB (NF-kappaB) is related to the grade of cervical intraepithelial neoplasia, but is not an independent predictor of high-risk human papillomavirus (HPV) or disease outcome in cervical cancer

Author

BRANCA M, GIORGI C, CIOTTI M, SANTINI D, COSTA S, BENEDETTO A, DI BONITO P, PABA P, ACCARDI L, MARIANI L, RUUTU M, SYRJÄNEN S, FAVALLI C, SYRJÄNEN K., DI BONITO, LUIGI, BONIFACIO, DANIELA, Branca, M, Giorgi, C, Ciotti, M, Santini, D, DI BONITO, Luigi, Costa, S, Benedetto, A, Bonifacio, Daniela, DI BONITO, P, Paba, P, Accardi, L, Mariani, L, Ruutu, M, Syrjänen, S, Favalli, C, and Syrjänen, K.

Published
2006

46. Aberrant expression of vascular endothelial growth factor-c (VEGF-C) is related to grade of cervical intraepithelial neoplasia (CIN), but does not predict virus clearance after treatment of CIN or prognosis of cervical cancer

Author

BRANCA M, GIORGI C, SANTINI D, CIOTTI M, COSTA S, BENEDETTO A, CASOLATI EA, FAVALLI C, PABA P, DI BONITO P, MARIANI L, SYRJANEN S, ACCARDI L, SYRJANEN K., DI BONITO, LUIGI, BONIFACIO, DANIELA, ZANCONATI, FABRIZIO, Branca, M, Giorgi, C, Santini, D, DI BONITO, Luigi, Ciotti, M, Costa, S, Benedetto, A, Casolati, Ea, Favalli, C, Paba, P, DI BONITO, P, Mariani, L, Syrjanen, S, Bonifacio, Daniela, Accardi, L, Zanconati, Fabrizio, and Syrjanen, K.

Published
2006

47. Cytological approach to an uncommon pulmonary neoplasm

Author

Dudine, S, Bonifacio, Daniela, Romano, A, Zanconati, Fabrizio, DI BONITO, Luigi, Dudine, S, Bonifacio, Daniela, Romano, A, Zanconati, Fabrizio, and DI BONITO, Luigi

Subjects
cytological diagnosis, Lung cancer
Published
2006

48. Cytological and mammographic correlation: Trieste's experience

Author

Zanconati, Fabrizio, Bonifacio, Daniela, Dudine, S, Martellani, F, Romano, A, Tonutti, M, DI BONITO, Luigi, Zanconati, Fabrizio, Bonifacio, Daniela, Dudine, S, Martellani, F, Romano, A, Tonutti, M, and DI BONITO, Luigi

Subjects
Mammography, cytology, breast lesions
Published
2006

50. Down-regulated nucleoside diphosphate (NDP) kinase nm23-H1 expression is unrelated to high-risk human papillomavirus (HPV) but associated with progression of CIN and unfavourable prognosis of cervical cancer

Author

Branca, M, Giorgi, C, Ciotti, M, Santini, D, DI BONITO, Luigi, Costa, S, Benedetto, A, Bonifacio, Daniela, Bonito, Di, P, Paba, P, Accardi, L, Mariani, L, Ruutu, M, Favalli, C, Syrjänen, K., Branca, M, Giorgi, C, Ciotti, M, Santini, D, DI BONITO, Luigi, Costa, S, Benedetto, A, Bonifacio, Daniela, Di, Bonito, P, Paba, P, Accardi, L, Mariani, L, Ruutu, M, Favalli, C, and Syrjänen, K.

Subjects
CIN, cervical intraepithelial neoplasia, Immunohistochemistry
Abstract

Objective: One of the factors leading to an invasive phenotype is the nm23 family of metastasesassociated genes. Of the six known members, nm23-H1 is the most frequently studied potential antimetastatic gene in cervical cancer. However, the possible molecular links to oncogenic human papillomavirus (HPV) are completely unexplored as yet. Materials and methods: As a part of the HPV-Pathogen Istituto Superiore di Sanita` study, a series of 150 squamous cell carcinomas (SCCs) and 152 cervical intraepithelial neoplasia (CIN) lesions were examined by immunohistochemical staining for nm23-H1, and tested for HPV by polymerase chain reaction (PCR) with three sets of primers (MY09/11, GP5+/GP6+ and short PCR fragment). Follow-up data were available on all patients with SCC, and 67 CIN lesions were monitored by serial PCR for clearance or persistence of HPV after cone treatment. Results: A linear decrease (p = 0.001) was observed in nm23-H1 expression, starting from CIN1 (85% with normal expression), with the most dramatic down regulation on transition from CIN2 (70% normal) to CIN3 (39%) and further to SCC (25%). Reduced expression was associated with CIN3 or cancer at an odds ratio 8.72 (95% confidence interval 4.13 to 18.41). Nm23-H1 was of no use as a marker of the high-risk human papillomavirus (HR-HPV) type, and it did not predict clearance or persistence of HR-HPV after treatment of CIN. Importantly, nm23-H1 expression was a significant prognostic factor in cervical cancer, reduced expression being associated with lower survival (p = 0.022) in univariate analysis. In the multivariate (Cox) regression model, however, only the International Federation of Gynecology and Obstetrics stage (p = 0.001) and age (p = 0.011) remained independent prognostic predictors. Conclusions: Down-regulated nm23-H1 expression is markedly associated with progression from CIN2 to CIN3, and predicts poor prognosis in cervical cancer. Nm23-H1 down regulation is probably orchestrated by mechanisms independent of HR-HPV oncoproteins and is possibly related to the emergence of a proteolytic phenotype.

Published
2006

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