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1. Treatment intensification following glucagon-like peptide-1 receptor agonist in type 2 diabetes: Comparative effectiveness analyses between free vs. fixed combination of GLP-1 RA and basal insulin. RESTORE-G real-world study

Author

Gabellieri, Enrico, Tortato, Elena, Rabini, Rosa Anna, Crazzolara, Dalia, Lucibelli, Luigi, Aragiusto, Concetta, Panzolato, Gianluigi, Di Mauro, Maurizio, Del Buono, Andrea, Placentino, Giuseppe, Di Cianni, Graziano, Brandoni, Gabriele, Fazion, Stefano, Gregori, Giovanna, Di Benedetto, Antonino, De Riva, Carlo, Terracciano, Annamaria, Zenari, Luciano, Cavalot, Franco, Porcellati, Francesca, Anichini, Roberto, Citro, Giuseppe, D'Angelo, Paola, Arca, Marcello, Morviducci, Lelio, Montani, Valeria, Fiorentini, Paolo, Candido, Riccardo, Nicolucci, Antonio, Larosa, Monica, Rossi, Maria Chiara, and Napoli, Raffaele

Published
2024
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2. Long-term benefits of dapagliflozin on renal outcomes of type 2 diabetes under routine care: a comparative effectiveness study on propensity score matched cohorts at low renal risk

Author

Baldassarre, Mariella, Consoli, Agostino, Morganet, Sara, Zugaro, Antonella, Baroni, Marco Giorgio, Andreozzi, Francesco, Gatti, Adriano, De Riu, Stefano, Del Buono, Andrea, Aldigeri, Raffaella, Bonadonna, Riccardo, Cas, Alessandra Dei, Vazzana, Angela, Antonini, Monica, Moretti, Valentina, Volsi, Patrizia Li, Cesare, Miranda, Zanette, Giorgio, Carletti, Silvia, D'Angelo, Paola, Leto, Gaetano, Leonetti, Frida, D'Onofrio, Luca, Maddaloni, Ernesto, Buzzetti, Raffaella, Frontoni, Simona, Cavallo, Giselle, Morano, Susanna, Filardi, Tiziana, Capece, Umberto, Giaccari, Andrea, Bossi, Antonio C., Meregalli, Giancarla, Querci, Fabrizio, Gaglio, Alessia, Resi, Veronica, Orsi, Emanuela, Fazion, Stefano, Franzetti, Ivano G., Berra, Cesare, Manfrini, Silvia, Garrapa, Gabriella, Lucarelli, Giulio, Riccialdelli, Lara, Tortato, Elena, Zavattaro, Marco, Aimaretti, Gianluca, Cavalot, Franco, Beccuti, Guglielmo, Broglio, Fabio, Fattor, Bruno, Cazzetta, Giuliana, Lamacchia, Olga, Rauseo, Anna, De Cosmo, Salvatore, Cau, Rosella, Ghiani, Mariangela, Di Benedetto, Antonino, Di Pino, Antonino, Piro, Salvatore, Purrello, Francesco, Frittitta, Lucia, Milluzzo, Agostino, Russo, Giuseppina, Fadini, Gian Paolo, Longato, Enrico, Morieri, Mario Luca, Del Prato, Stefano, Avogaro, Angelo, and Solini, Anna

Published
2024
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3. Treatment intensification following glucagon-like peptide-1 receptor agonist treatment in type 2 diabetes: The RESTORE-G real-world study

Author

Gabellieri, Enrico, Tortato, Elena, Rabini, Rosa Anna, Crazzolara, Dalia, Lucibelli, Luigi, Aragiusto, Concetta, Panzolato, Gianluigi, Di Mauro, Maurizio, Del Buono, Andrea, Placentino, Giuseppe, Di Cianni, Graziano, Brandoni, Gabriele, Fazion, Stefano, Gregori, Giovanna, Di Benedetto, Antonino, De Riva, Carlo, Terracciano, Annamaria, Napoli, Raffaele, Zenari, Luciano, Cavalot, Franco, Porcellati, Francesca, Anichini, Roberto, Citro, Giuseppe, D'Angelo, Paola, Arca, Marcello, Morviducci, Lelio, Montani, Valeria, Fiorentini, Paolo, Candido, Riccardo, Nicolucci, Antonio, Larosa, Monica, and Rossi, Maria Chiara

Published
2023
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4. Treatment intensification following glucagon‐like peptide‐1 receptor agonists in type 2 diabetes: Comparative effectiveness analyses between different basal insulins. RESTORE‐G real‐world study.

Author

Napoli, Raffaele, Nicolucci, Antonio, Larosa, Monica, Rossi, Maria Chiara, Candido, Riccardo, Aragiusto, Concetta, Arca, Marcello, Anichini, Roberto, Brandoni, Gabriele, Cavalot, Franco, Citro, Giuseppe, Crazzolara, Dalia, D'Angelo, Paola, Del Buono, Andrea, De Riva, Carlo, Di Benedetto, Antonino, Di Cianni, Graziano, Di Mauro, Maurizio, Fazion, Stefano, and Fiorentini, Paolo

Subjects
TYPE 2 diabetes, INSULIN receptors, PROPENSITY score matching, ELECTRONIC health records, BLOOD sugar
Abstract

Aim: To compare the effectiveness of different basal insulins (BI) prescribed as an add‐on to or switch from glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) therapy. Materials and Methods: Retrospective, real‐world data from electronic medical records of 32 Italian diabetes clinics were used, after propensity score adjustment, to compare effectiveness after 6 months of treatment with second‐ versus first‐generation BI (2BI vs. 1BI) or glargine 300 U/ml versus degludec 100 U/ml (Gla‐300 vs. Deg‐100), when added to (ADD‐ON) or in substitution of (SWITCH) GLP‐1 RA. Only comparisons, including a minimum of 100 patients per group, were performed to ensure adequate robustness of the analyses. Results: In the ADD‐ON cohort (N = 700), greater benefits of 2BI versus 1BI were found in glycated haemoglobin {HbA1c; estimated mean difference: −0.32% [95% confidence interval (CI) −0.62; −0.02]; p =.04} and fasting blood glucose [FBG; −20.73 mg/dl (95% CI −35.62; −5.84); p =.007]. In the SWITCH cohort (N = 2097), greater benefits of 2BI versus 1BI were found in HbA1c [−0.22% (95% CI −0.42; −0.02); p =.03], FBG [−10.15 mg/dl (95% CI −19.04; −1.26); p =.03], and body weight [−0.67 kg (95% CI −1.30; −0.04); p =.04]. In the SWITCH cohort starting 2BI (N = 688), marked differences in favour of Gla‐300 versus Deg‐100 were documented in HbA1c [−0.89% (95% CI −1.26; −0.52); p <.001] and FBG [−17.89 mg/dl (95% CI −32.45; −3.33); p =.02]. Using propensity score matching as a sensitivity analysis, the benefit on HbA1c was confirmed [−0.55% (95% CI –1.02; −0.08); p =.02]. BI titration was suboptimal in all examined cohorts. Conclusions: 2BI are a valuable option to intensify GLP‐1 RA therapy. Switching to Gla‐300 versus Deg‐100 was associated with greater HbA1c improvement. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Long-term benefits of dapagliflozin on renal outcomes of type 2 diabetes under routine care: a comparative effectiveness study on propensity score matched cohorts at low renal risk

Author

Fadini, Gian Paolo, primary, Longato, Enrico, additional, Morieri, Mario Luca, additional, Del Prato, Stefano, additional, Avogaro, Angelo, additional, Solini, Anna, additional, Baldassarre, Mariella, additional, Consoli, Agostino, additional, Morganet, Sara, additional, Zugaro, Antonella, additional, Baroni, Marco Giorgio, additional, Andreozzi, Francesco, additional, Gatti, Adriano, additional, De Riu, Stefano, additional, Del Buono, Andrea, additional, Aldigeri, Raffaella, additional, Bonadonna, Riccardo, additional, Cas, Alessandra Dei, additional, Vazzana, Angela, additional, Antonini, Monica, additional, Moretti, Valentina, additional, Volsi, Patrizia Li, additional, Cesare, Miranda, additional, Zanette, Giorgio, additional, Carletti, Silvia, additional, D'Angelo, Paola, additional, Leto, Gaetano, additional, Leonetti, Frida, additional, D'Onofrio, Luca, additional, Maddaloni, Ernesto, additional, Buzzetti, Raffaella, additional, Frontoni, Simona, additional, Cavallo, Giselle, additional, Morano, Susanna, additional, Filardi, Tiziana, additional, Capece, Umberto, additional, Giaccari, Andrea, additional, Bossi, Antonio C., additional, Meregalli, Giancarla, additional, Querci, Fabrizio, additional, Gaglio, Alessia, additional, Resi, Veronica, additional, Orsi, Emanuela, additional, Fazion, Stefano, additional, Franzetti, Ivano G., additional, Berra, Cesare, additional, Manfrini, Silvia, additional, Garrapa, Gabriella, additional, Lucarelli, Giulio, additional, Riccialdelli, Lara, additional, Tortato, Elena, additional, Zavattaro, Marco, additional, Aimaretti, Gianluca, additional, Cavalot, Franco, additional, Beccuti, Guglielmo, additional, Broglio, Fabio, additional, Fattor, Bruno, additional, Cazzetta, Giuliana, additional, Lamacchia, Olga, additional, Rauseo, Anna, additional, De Cosmo, Salvatore, additional, Cau, Rosella, additional, Ghiani, Mariangela, additional, Di Benedetto, Antonino, additional, Di Pino, Antonino, additional, Piro, Salvatore, additional, Purrello, Francesco, additional, Frittitta, Lucia, additional, Milluzzo, Agostino, additional, and Russo, Giuseppina, additional

Published
2024
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11. Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial

Author

Vaccaro, Olga, Masulli, Maria, Nicolucci, Antonio, Maggioni, Aldo Pietro, Sesti, Giorgio, Mocarelli, Paolo, Lucisano, Giuseppe, Sacco, Michele, Signorini, Stefano, Cappellini, Fabrizio, Riccardi, Gabriele, Boemi, Massimo, D'Angelo, Federica, Giansanti, Roberto, Tanase, Laura, Lanari, Luigi, Testa, Ivano, Ricci, Lucia, Pancani, Francesca, Ranchelli, Anna, Vagheggi, Paolo, Scatona, Alessia, Fontana, Lucia, Giorgino, Francesco, Laviola, Luigi, Tarantino, Lucia, Ippolito, Claudia, Gigantelli, Vittoria, Manicone, Mariangela, Conte, Eleonora, Trevisan, Roberto, Scaranna, Cristiana, Rota, Rossella, Corsi, Anna, Dodesini, Alessandro R., Reggiani, Giulio Marchesini, Montesi, Luca, Mazzella, Natalia, Forlani, Gabriele, Caselli, Chiara, Di Luzio, Raffaella, Mazzotti, Arianna, Aiello, Antimo, Barrea, Angelina, Musto, Antonio, D'Amico, Fiorentina, Squatrito, Sebastiano, Sinagra, Tiziana, Longhitano, Sara, Trowpea, Vanessa, Sparti, Maria, Italia, Salvatore, Lisi, Enrico, Grasso, Giuseppe, Pezzino, Vincenzo, Insalaco, Federica, Gnasso, Agostino, Carallo, Claudio, Scicchitano, Caterina, De Franceschi, Maria Serena, Santini, Costanza, Calbucci, Giovanni, Ripani, Raffaella, Corsi, Laura, Cuneo, Giacomo, Corsi, Simona, Giorda, Carlo B., Romeo, Francesco, Lesina, Annalisa, Comoglio, Marco, Bonetto, Caterina, Robusto, Anna, Nada, Elisa, Asprino, Vincenzo, Cetraro, Rosa, Impieri, Michelina, Lucchese, Giuseppe, Donnarumma, Giovanna, Tizio, Biagio, Clemente, Gennaro, Lenza, Lazzaro, Paraggio, Pia, Tomasi, Franco, Zamboni, Chiara, Dozio, Nicoletta, Scalambra, Egle, Mannucci, Edoardo, Lamanna, Caterina, Cignarelli, Mauro, Macchia, Olga La, Fariello, Stefania, Sorrentino, Maria Rosaria, Franzetti, Ivano, Radin, Raffaella, Cordera, Renzo, Annunziata, Francesca, Bonabello, Laura Affinito, Durante, Arianna, Dolcino, Mara, Gallo, Fiorenza, Mazzucchelli, Chiara, Aleo, Anna, Melga, Pierluigi, Briatore, Lucia, Maggi, Davide, Storace, Daniela, Cecoli, Francesca, Antenucci, Daniela, D'Ugo, Ercole, Pupillo, Mario, Baldassarre, Maria Pompea Antonia, Salvati, Filippo, Minnucci, Anita, De Luca, Angelo, Zugaro, Antonella, Santarelli, Livia, Bosco, Angela, Petrella, Vittorio, La Verghetta, Grazia Giovanna, Iannarelli, Rossella, De Gregorio, Antonella, D'Andrea, Settimio, Giuliani, Anna Elisa, Polidoro, w Lorella, Sperandio, Alessandra, Sciarretta, Filomena, Pezzella, Alfonso, Buzzetti, Raffaella, Carlone, Angela, Potenziani, Stella, Venditti, Chiara, Foffi, Chiara, Carbone, Salvatore, Cipolloni, Laura, Moretti, Chiara, Leto, Gaetano, Serra, Rosalia, Petrachi, Francesca, Romano, Isabella, Di Cianni, Graziano, Lacaria, Emilia, Russo, Laura, Goretti, Chiara, Sannino, Claudia, Gregori, Giovanna, Dolci, Maria, Bruselli, Laura, Mori, Mary L., Baccetti, Fabio, Del Freo, Maria, Di Benedetto, Antonino, Cucinotta, Domenico, Giunta, Loretta, Ruffo, Maria Concetta, Cannizzaro, Desiree, Pintaudi, Basilio, Perrone, Giovanni, Pata, Pietro, Ragonese, Francesco, Lettina, Gabriele, Mancuso, Teresa, Coppolino, Aldo, Piatti, Pier Marco, Monti, Lucilla, Stuccillo, Michela, Lucotti, Pietro, Setola, Manuela, Crippa, Giulia Valentina, Loi, Cinzia, Oldani, Matteo, Bottalico, Maria Luisa, Pellegata, Beatrice, Bonomo, Matteo, Menicatti, Laura Silvia Maria, Resi, Veronica, Bertuzzi, Federico, Disoteo, Eugenia Olga, Pizzi, Gianluigi, Rivellese, Angela Albarosa, Annuzzi, Giovanni, Capaldo, Brunella, Nappo, Rossella, Auciello, Stefania Michela, Turco, Anna Amelia, Costagliola, Lucia, Iovine, Ciro, Corte, Giuseppina Della, Vallefuoco, Pasquale, Nappi, Francesca, Vitale, Marilena, Cocozza, Sara, Ciano, Ornella, Massimino, Elena, Garofalo, Nadia, Avogaro, Angelo, Vedovato, Monica, Guarneri, Gabriella, Lapolla, Annunziata, Fedele, Domenico, Sartore, Giovanni, Chilelli, Nino Cristiano, Burlina, Silvia, Bonsembiante, Barbara, Giordano, Carla, Galluzzo, Aldo, Torregrossa, Vittoria, Dall'Aglio, Elisabetta, Mancastroppa, Giovanni, Arsenio, Leone, Cioni, Federico, Caronna, Silvana, Papi, Matteo, Babini, Massimiliano, Perriello, Gabriele, Santeusanio, Fausto, Calagreti, Gioia, Timi, Alessia, Tantucci, Alice, Marino, Cecilia, Consoli, Agostino, Ginestra, Federica, Di Biagio, Rosamaria, Taraborelli, Merilda, Del Prato, Stefano, Miccoli, Roberto, Bianchi, Cristina, Garofolo, Monia, Politi, Konstantina Savina, Penno, Giuseppe, Zavaroni, Donatella, Livraga, Stefania, Calzoni, Fabio, Mancastroppa, Giovanni Luigi Francesco, Anichini, Roberto, Corsini, Elisa, Tedeschi, Anna, Gaglianò, Maria Sole, Ippolito, Giulio, Salutini, Elisabetta, Citro, Giuseppe, Cervellino, Francesco, Natale, Maria, Salvatore, Vita, Zampino, Armando, Sinisi, Rosa, Calabrese, Maria, Arcangeli, Adolfo, Zogheri, Alessia, Guizzotti, Sandra, Longo, Rossella, Di Bartolo, Paolo, Pellicano, Francesca, Scolozzi, Patrizia, Termine, Simona, Luberto, Alessandra, Ballardini, Giorgio, Babini, Anna Carla, Trojani, Cristina, Mazzuca, Paolo, Bruglia, Matteo, Ciamei, Monica, Genghini, Silvia, Zannoni, Chiara, Pugliese, Giuseppe, Vitale, Martina, Rangel, Graziela, Salvi, Laura, Zappaterreno, Alessandra, Cordone, Samantha, Simonelli, Paola, Meggiorini, Marilla, Frasheri, Aurora, Di Pippo, Clelia, Maglio, Cristina, Mazzitelli, Giulia, Lauro, Davide, Rinaldi, Maria Elena, Galli, Angelica, Romano, Maria, D'Angelo, Paola, Leotta, Sergio, Suraci, Concetta, De Cosmo, Salvatore, Bacci, Simonetta, Palena, Antonio Pio, Genovese, Stefano, Mancino, Monica, Rondinelli, Maurizio, Capone, Filippo, Calabretto, Elisabetta, Bulgheroni, Monica, Bucciarelli, Loredana, Dotta, Francesco, Ceccarelli, Elena, Fondelli, Cecilia, Santacroce, Clorinda, Guarino, Elisa, Nigi, Laura, Lalli, Carlo, Di Vizia, Giovanni, Scarponi, Maura, Montani, Valeria, Di Bernardino, Paolo, Romagni, Paola, Dolcetti, Katia, Cannarsa, Emanuela, Forte, Elisa, Tamburo, Lucilla, Fornengo, Paolo, Perin, Paolo Cavallo, Prinzis, Tania, Gruden, Gabriella, Bruno, Graziella, Zucco, Chiara, Perotta, Massimo, Marena, Saverio, Monsignore, Simona, Panero, Francesco, Ponzi, Fulvia, Bossi, Antonio Carlo, Carpinteri, Rita, Casagrande, Maria Linda, Coletti, Maria Francesca, Balini, Annalisa, Filopanti, Marcello, Madaschi, Sara, Pulcina, Anna, Grimaldi, Franco, Tonutti, Laura, Venturini, Giorgio, Agus, Sandra, Pagnutti, Stefania, Guidotti, Francesca, Cavarape, Alessandro, Bonora, Enzo, Cigolini, Massimo, Pichiri, Isabella, Brangani, Corinna, Fainelli, Giulia, Tomasetto, Elena, Zoppini, Giacomo, Galletti, Anna, Perrone, Dominica, Capra, Claudio, Bianchini, Francesca, Ceseri, Martina, Di Nardo, Barbara, Sasso, Elisa, Bartolomei, Barbara, Suliman, Irina, Fabbri, Gianna, Romano, Geremia, Maturo, Nicola, Nunziata, Giuseppe, Capobianco, Giuseppe, De Simone, Giuseppina, Villa, Valeria, Rota, Giuseppe, Pentangelo, Carmine, Carbonara, Ornella, Caiazzo, Gennaro, Cutolo, Michele, Sorrentino, Tommasina, Mastrilli, Valeria, Amelia, Umberto, Masi, Stefano, Corigliano, Gerardo, Gaeta, Iole, Armentano, Vincenzo, Calatola, Pasqualino, Capuano, Gelsomina, Angiulli, Bruno, Auletta, Pasquale, Petraroli, Ettore, Iodice, Cinzia E., Agrusta, Mariano, Maggioni, Aldo P, Rivellese, Angela A, Giorda, Carlo B, La Macchia, Olga, Bossi, Antonio C, and di Bartolo, Paolo

Published
2017
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12. Treatment Intensification following Glucagon-Like Peptide-1 Receptor Agonist Treatment in Type 2 Diabetes: the RESTORE-G Real-World Study

Author

Candido, Riccardo, primary, Nicolucci, Antonio, additional, Larosa, Monica, additional, Rossi, Maria Chiara, additional, Napoli, Raffaele, additional, Gabellieri, Enrico, additional, Tortato, Elena, additional, Rabini, Rosa Anna, additional, Lucibelli, Luigi, additional, Aragiusto, Concetta, additional, Panzolato, Gianluigi, additional, Di Mauro, Maurizio, additional, Del Buono, Andrea, additional, Placentino, Giuseppe, additional, Brandoni, Gabriele, additional, Fazion, Stefano, additional, Gregori, Giovanna, additional, Di Benedetto, Antonino, additional, De Riva, Carlo, additional, Terracciano, Annamaria, additional, Cavalot, Franco, additional, Anichini, Roberto, additional, Citro, Giuseppe, additional, D'Angelo, Paola, additional, Arca, Marcello, additional, Morviducci, Lelio, additional, Montani, Valeria, additional, and Porcellati, Francesca, additional

Published
2023
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14. Ocular Surface Changes in Type 1 Diabetic Patients

Author

Aragona, Pasquale, Giuffrida, Sebastiano, Di Stefano, Giuseppe, Ferreri, Felicia, Di Benedetto, Antonino, Bucolo, Claudio, Cro, Melina, Sullivan, David A., editor, Stern, Michael E., editor, Tsubota, Kazuo, editor, Dartt, Darlene A., editor, Sullivan, Rose M., editor, and Bromberg, B. Britt, editor

Published
2002
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15. Comparative effectiveness of Glargine 300 U/mL vs. Degludec 100 U/mL in patients with type 2 diabetes switching from 1° generation basal insulins

Author

Raffaella Buzzetti, Gian Paolo Fadini, Antonio Nicolucci, Monica Larosa, Maria Chiara Rossi, Domenico Cucinotta, Gabellieri Enrico, Alpestre Mauro, Marangoni Alberto, Bassano del Grappa, Pagotto Uberto, Bongiorno Claudio, Gatta Concetta, Del Buono Andrea, Lamacchia Olga, Maiellaro Pasquale, Antenucci Daniela, Brandoni Gabriele, Borroni Francesca, Gregori Giovanna, Di Benedetto Antonino, Placentino Giuseppe, Cavalot Franco, Barale Cristina, Fadini Gian Paolo, Del Sindaco Paola, Di Loreto Chiara, Anichini Roberto, Citro Giuseppe, D'Angelo Paola, Carletti Silvia, Buzzetti Raffaella, Sterpetti Sara, Carmen Mignogna, Elli Paolo, Giuseppe Prosperini, Michele Sacco, and Giuseppe Lucisano

Subjects
Blood Glucose, Glycated Hemoglobin A, Basal insulin, Degludec 100, Effectiveness, Glargine 300, Safety, Switch, Type 2 diabetes, Humans, Hypoglycemic Agents, Insulin Glargine, Insulin, Long-Acting, Retrospective Studies, Diabetes Mellitus, Type 2, Hypoglycemia, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Diabetes Mellitus, Insulin, Long-Acting, Glycated Hemoglobin, Nutrition and Dietetics, Cardiology and Cardiovascular Medicine, Type 2
Abstract

Data on second generation basal insulin (2BI) in people with type 2 diabetes (T2D) generated by clinical trials still need confirmation in real-world clinical settings. This study aimed at assessing the comparative effectiveness of 2BI [Glargine 300 U/mL (Gla-300) vs. Degludec 100 U/mL (Deg-100)] in T2D Italian patients switching from first generation basal insulins (1BI).This was a retrospective, non-inferiority, multicenter study. Patients switching to Gla-300 or Deg-100 from 1BI were 1:1 propensity score matched (PSM). Changes during 6 months in continuous endpoints were assessed through linear mixed models. Incidence rates (IR) of hypoglycemia (episodes per patient-months) were compared using Poisson regression. Each PSM cohort included 593 patients. HbA1c decreased from baseline (8.7%) to 6 months by -0.58% (95%CI -0.69;-0.47) in Gla-300 group and -0.50% (95%CI -0.61;-0.39) in Deg-100 group, confirming the non-inferiority of Gla-300 vs. Deg-100. No between-group differences emerged: FBG was reduced by about 20 mg/dl with both 2BI, mean dose of 2BI (24.5 U, 0.3 U/Kg at the first prescription) was suboptimally titrated during 6 months (+1.34 U in Gla-300 and + 1.76 U in Deg-100), body weight showed minor changes. IR of hypoglycemia54 mg/dl was 0.32 (95%CI 0.21; 0.49) in Gla-300 group and 0.19 (95%CI 0.11; 0.33) in Deg-100 group (p = 0.14).In subjects with T2D, switching to 2BI from 1BI was associated with similar improvements in glycemic control, low hypoglycemia rates and no weight gain in real-life setting. Clinical inertia, represented by late treatment intensification and suboptimal titration, represents a major issue in Italy.

Published
2022

20. The impact of clinical and psychological characteristics on alexithymia in type 1 diabetes

Author

Pintaudi, Basilio, Di Vieste, Giacoma, Nicolucci, Antonio, Bruno, Antonio, Genovese, Giovanni, Muscatello, Maria Rosaria Anna, Cedro, Clemente, Zoccali, Rocco Antonio, and Di Benedetto, Antonino

Subjects
Alexithymia, BMI, Type 1 diabetes, Psychological outcomes, Anxiety
Abstract

Background: Alexithymia is a psychological construct characterized by inability to express emotions, poor imagination and operational thinking. It is well known its association with several chronic disease such as Diabetes type 2, little is known about diabetes type 1. We examined the association of alexithymia with clinical and psychological outcomes in subjects with type 1 diabetes. Methods: The study was conducted in a single diabetes center. The patients fully completed a protocol composed of the following instruments: the Toronto Alexithymia Scale-20 (TAS-20), the State-Trait Anger Expression Inventory-2 (STAXI-2), the State-Trait Anxiety Inventory form Y (STAI-Y), and the Hamilton Rating Scale for Depression (HAMD). TAS-20 scores were subdivided into tertiles, Correlations and two linear regression analyses, adjusted for only clinical and clinical plus psychological characteristics, were performed. Overall, 75 patients were enrolled (mean age 41.0±11.4 years, diabetes duration 19.9±11.9 years, 49.3% males, 30.7% treated with CSII). Results: People with diabetes of the upper TAS-20 tertile had the greatest rate of depression (with the highest degree of severity) and the higher levels of anger and anxiety. There was a significant correlation between TAS-20 scores with BMI (r=0.26; p=0.03), HAMD (r=0.38; p=0.001), STAXI-2 (r=0.34; p=0.003) and STAI-Y (r=0.48; p0.0001). Further regression analysis showed TAS-20 scores were associated with BMI (beta=0.29; p=0.02). The association with BMI was confirmed (beta=0.28; p=0.007) when psychological variables are considered; furthermore, a strong association with STAI-2 (beta=0.48; p0.0001) was detected, while the analysis did reveal any significant correlation between alexithymia and HbA1c levels. Conclusions: Alexithymia is strongly associated both with clinical and psychological characteristics, notably with BMI and anxiety traits. People with diabetes type 1 should be assessed for alexithymia. Future studies on the current topic are therefore required in order to elucidate the role of alexithymia in diabetes type 1. We believe that patients with diabetes and alexithymia could take advantage of psychological counseling., Mediterranean Journal of Clinical Psychology, Vol 9, No 2 (2021)

Published
2021

23. Cluster analysis identifies patients at risk of catheter-associated urinary tract infections in intensive care units: findings from the SPIN-UTI Network

Author

Barchitta, M., primary, Maugeri, A., additional, Favara, G., additional, Riela, P.M., additional, La Mastra, C., additional, La Rosa, M.C., additional, San Lio, R. Magnano, additional, Gallo, G., additional, Mura, I., additional, Agodi, A., additional, Brusaferro, Marco, additional, Fenaroli, Salesia, additional, Sicoli, Ennio, additional, Montagna, Maria Teresa, additional, Squeri, Raffaele, additional, Di Bartolo, Rosario Massimo, additional, Tribastoni, Salvatore, additional, Mattaliano, Anna Rita, additional, Bellocchi, Patrizia, additional, Castiglione, Giacomo, additional, Astuto, Marinella, additional, Longhitano, Anna Maria, additional, Monea, Maria Concetta, additional, Scrofani, Giorgio, additional, Di Benedetto, Antonino, additional, Riggio, Maria Carmela, additional, Manta, Giuseppe, additional, Tetamo, Romano, additional, Dei, Ignazio, additional, Pandiani, Irene, additional, Cannistrà, Antonino, additional, Piotti, Paola, additional, Girardis, Massimo, additional, Righi, Elena, additional, Sarchi, Pierangelo, additional, Arnoldo, Luca, additional, Brusaferro, Silvio, additional, Coniglio, Salvatore, additional, Borracino, Albino, additional, Pintaudi, Sergio, additional, Minerva, Massimo, additional, Milazzo, Marina, additional, Bissolo, Emanuela, additional, Rigo, Alberto, additional, Fabiani, Leila, additional, Marinangeli, Franco, additional, Stefanini, Paolo, additional, D'Errico, Marcello Mario, additional, Donati, Abele, additional, Tardivo, Stefano, additional, Moretti, Francesca, additional, Carli, Alberto, additional, Pagliarulo, Riccardo, additional, Bianco, Aida, additional, Pavia, Maria, additional, Pasculli, Marcello, additional, Vittori, Cesare, additional, Orsi, Giovanni Battista, additional, Arrigoni, Cristina, additional, Laurenti, Patrizia, additional, Ingala, Franco, additional, and Farruggia, Patrizia, additional

Published
2021
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24. Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes – a randomized and open-label, placebo-controlled clinical trial

Author

Vitale, Salvatore Giovanni, primary, Corrado, Francesco, additional, Caruso, Salvatore, additional, Di Benedetto, Antonino, additional, Giunta, Loretta, additional, Cianci, Antonio, additional, and D’Anna, Rosario, additional

Published
2020
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26. Genistein in the Metabolic Syndrome: Results of a Randomized Clinical Trial

Author

Squadrito, Francesco, Marini, Herbert, Bitto, Alessandra, Altavilla, Domenica, Polito, Francesca, Adamo, Elena Bianca, DʼAnna, Rosario, Arcoraci, Vincenzo, Burnett, Bruce P., Minutoli, Letteria, Di Benedetto, Antonino, Di Vieste, Giacoma, Cucinotta, Domenico, de Gregorio, Cesare, Russo, Silvia, Corrado, Francesco, Saitta, Antonino, Irace, Concetta, Corrao, Salvatore, and Licata, Giuseppe

Published
2013

28. Myo-inositol supplementation to prevent gestational diabetes in overweight non-obese women: bioelectrical impedance analysis, metabolic aspects, obstetric and neonatal outcomes – a randomized and open-label, placebo-controlled clinical trial.

Author

Vitale, Salvatore Giovanni, Corrado, Francesco, Caruso, Salvatore, Di Benedetto, Antonino, Giunta, Loretta, Cianci, Antonio, and D'Anna, Rosario

Subjects
GESTATIONAL diabetes, BIOELECTRIC impedance, OVERWEIGHT women, BODY composition, CLINICAL trials, PREGNANT women
Abstract

This study aims to evaluate the effects of myo-inositol supplementation on gestational diabetes mellitus (GDM) rates and body water distribution in overweight non-obese women. 223 overweight non-obese women pregnant were randomly assigned to the treatment group (2 g of myo-inositol plus 200 µg of folic acid) or to the placebo one (200 µg of folic acid). The treatment lasted until three weeks after delivery. A tetrapolar impedance analyser was used to study body composition. The incidence of GDM was significantly reduced in the myo-inositol group compared with the placebo group. There was a significant increase in TBW, ECW and ICW values in the placebo group compared to the myo-inositol group. We have recorded a significant reduction in the overall incidence of pregnancy-induced hypertension in the myo-inositol group compared with the placebo group. Our results demonstrate the effectiveness of myo-inositol supplementation in preventing GDM in overweight non-obese pregnant women. [ABSTRACT FROM AUTHOR]

Published
2021
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31. Epidemiology of intensive care unit-acquired sepsis in Italy: Results of the SPIN-UTI network

Author

Agodi, Antonella, Barchitta, M., Auxilia, F., Brusaferro, S., D'Errico, M. M., Montagna, M. T., Pasquarella, C., Tardivo, S., Arrigoni, C., Fabiani, L., Laurenti, P., Mattaliano, A. R., Orsi, G. B., Squeri, R., Torregrossa, M. V., Mura, I., Aiello, Mary Rose, Alliani, Cristina, Amatucci, Maria Rita, Antoci, Manuela, Antonelli, Massimo, Astuto, Marinella, Arnoldo, Luca, Arru, Benedetto, Baccari, Giorgio, Barbadoro, Pamela, Barbara, Andrea, Barilaro, Cynthia, Battaglia, Pietro, Bellocchi, Patrizia, Bernasconi, Mara Olga, Bianco, Aida, Bissolo, Emanuela, Bocchi, Anna, Bruno, Anna, Brusaferro, Marco, Buccheri, Margherita, Campanella, Francesca, Canino, Rosario, Cannistrà, Antonino, Carini, Santa Adele, Catalano, Sebastiano, Castellani, Paola, Castiglione, Giacomo, Coniglio, Salvatore, Consolante, Ciriaco, Conte, Carmela, Contrisciani, Roberta, Corallini, Rosy, Crollari, Patricia, Damiani, Gianfranco, Denaro, Carmelo, De Remigis, Santa, Diana, Francesca, Di Bartolo, Rosario, Di Benedetto, Antonino, Di Fabio, Gianna, Di Falco, Carlo, Digeronimo, Vito, Di Gregorio, Pietro, Distefano, Roberta, Egitto, Giovanni, Falciani, Elena, Farruggia, Patrizia, Fenaroli, Salesia, Ferlazzo, Giuseppe, Garofalo, Giuseppe, Girardis, Massimo, Giovanelli, Linda, Giubbini, Gabriele, Graceffa, Adriana, Guadagna, Antonina, Gregu, Giovanna, Ingala, Franco, Innocenzi, Ludovico, La Camera, Giuseppa, La Rosa, Maria Clara, Lesa, Lucia, Longhitano, Anna Maria, Luppino, Giuseppe, Maida, Carmelo Massimo, Manta, Giuseppe, Marino, Giovanni, Masia, Maria Dolores, Maviglia, Riccardo, Mazzetti, Magda, Maugeri, Andrea, Megna, Maria Teresa, Mella, Laura Maria, Milazzo, Marina, Milia, Mario, Minari, Caterina, Minerva, Massimo, Mordacci, Marco, Murgia, Paola, Oliveri, Pietro, Olori, Maria Patrizia, Pagliarulo, Riccardo, Palermo, Rosanna, Pandiani, Irene, Pappalardo, Federico, Papetti, Cristina, Partenza, Adolfo, Pascu, Diana, Pasculli, Marcello, Pavia, Maria, Pavone, Maria Luisa, Pellegrino, Maria Giovanna, Pelligra, Fabrizio, Pillon, Danila, Pintaudi, Sergio, Pitzoi, Lucia, Pinto, Andrea, Piotti, Paola, Pupo, Simona, Quattrocchi, Rosalba, Righi, Elena, Rigo, Alberto, Rigo, Annalisa, Romeo, Antonina, Rosa, Emilio, Rutigliano, Serafina, Sarchi, Pierangelo, Scimonello, Guglielmo, Seminerio, Antonello, Stefanini, Paolo, Sticca, Giovanna, Taddei, Stefania, Tessari, Lorella, Tetamo, Romano, Ticca, Mariantonietta, Tribastoni, Salvatore, Vallorani, Sarah, Venturoni, Federica, Vitagliano, Emilia, Vitali, Pietro, Zappone, Assunta, Zei, Ettore, Zeoli, Maria Prudenzia, Agodi A., Barchitta M., Auxilia F., Brusaferro S., D'Errico M.M., Montagna M.T., Pasquarella C., Tardivo S., Arrigoni C., Fabiani L., Laurenti P., Mattaliano A.R., Orsi G.B., Squeri R., Torregrossa M.V., Mura I., Aiello M.R., Alliani C., Amatucci M.R., Antoci M., Antonelli M., Astuto M., Arnoldo L., Arru B., Baccari G., Barbadoro P., Barbara A., Barilaro C., Battaglia P., Bellocchi P., Bernasconi M.O., Bianco A., Bissolo E., Bocchi A., Bruno A., Brusaferro M., Buccheri M., Campanella F., Canino R., Cannistra A., Carini S.A., Catalano S., Castellani P., Castiglione G., Coniglio S., Consolante C., Conte C., Contrisciani R., Corallini R., Crollari P., Damiani G., Denaro C., De Remigis S., Diana F., Di Bartolo R., Di Benedetto A., Di Fabio G., Di Falco C., Digeronimo V., Di Gregorio P., Distefano R., Egitto G., Falciani E., Farruggia P., Fenaroli S., Ferlazzo G., Garofalo G., Girardis M., Giovanelli L., Giubbini G., Graceffa A., Guadagna A., Gregu G., Ingala F., Innocenzi L., La Camera G., La Rosa M.C., Lesa L., Longhitano A.M., Luppino G., Maida C.M., Manta G., Marino G., Masia M.D., Maviglia R., Mazzetti M., Maugeri A., Megna M.T., Mella L.M., Milazzo M., Milia M., Minari C., Minerva M., Mordacci M., Murgia P., Oliveri P., Olori M.P., Pagliarulo R., Palermo R., Pandiani I., Pappalardo F., Papetti C., Partenza A., Pascu D., Pasculli M., Pavia M., Pavone M.L., Pellegrino M.G., Pelligra F., Pillon D., Pintaudi S., Pitzoi L., Pinto A., Piotti P., Pupo S., Quattrocchi R., Righi E., Rigo A., Romeo A., Rosa E., Rutigliano S., Sarchi P., Scimonello G., Seminerio A., Stefanini P., Sticca G., Taddei S., Tessari L., Tetamo R., Ticca M., Tribastoni S., Vallorani S., Venturoni F., Vitagliano E., Vitali P., Zappone A., Zei E., Zeoli M.P., Agodi, A., Barchitta, M., Auxilia, F., Brusaferro, S., D'Errico, M. M., Montagna, M. T., Pasquarella, C., Tardivo, S., Arrigoni, C., Fabiani, L., Laurenti, P., Mattaliano, A. R., Orsi, G. B., Squeri, R., Torregrossa, M. V., Mura, I., Aiello, M. R., Alliani, C., Amatucci, M. R., Antoci, M., Antonelli, M., Astuto, M., Arnoldo, L., Arru, B., Baccari, G., Barbadoro, P., Barbara, A., Barilaro, C., Battaglia, P., Bellocchi, P., Bernasconi, M. O., Bianco, A., Bissolo, E., Bocchi, A., Bruno, A., Brusaferro, M., Buccheri, M., Campanella, F., Canino, R., Cannistra, A., Carini, S. A., Catalano, S., Castellani, P., Castiglione, G., Coniglio, S., Consolante, C., Conte, C., Contrisciani, R., Corallini, R., Crollari, P., Damiani, G., Denaro, C., De Remigis, S., Diana, F., Di Bartolo, R., Di Benedetto, A., Di Fabio, G., Di Falco, C., Digeronimo, V., Di Gregorio, P., Distefano, R., Egitto, G., Falciani, E., Farruggia, P., Fenaroli, S., Ferlazzo, G., Garofalo, G., Girardis, M., Giovanelli, L., Giubbini, G., Graceffa, A., Guadagna, A., Gregu, G., Ingala, F., Innocenzi, L., La Camera, G., La Rosa, M. C., Lesa, L., Longhitano, A. M., Luppino, G., Maida, C. M., Manta, G., Marino, G., Masia, M. D., Maviglia, R., Mazzetti, M., Maugeri, A., Megna, M. T., Mella, L. M., Milazzo, M., Milia, M., Minari, C., Minerva, M., Mordacci, M., Murgia, P., Oliveri, P., Olori, M. P., Pagliarulo, R., Palermo, R., Pandiani, I., Pappalardo, F., Papetti, C., Partenza, A., Pascu, D., Pasculli, M., Pavia, M., Pavone, M. L., Pellegrino, M. G., Pelligra, F., Pillon, D., Pintaudi, S., Pitzoi, L., Pinto, A., Piotti, P., Pupo, S., Quattrocchi, R., Righi, E., Rigo, A., Romeo, A., Rosa, E., Rutigliano, S., Sarchi, P., Scimonello, G., Seminerio, A., Stefanini, P., Sticca, G., Taddei, S., Tessari, L., Tetamo, R., Ticca, M., Tribastoni, S., Vallorani, S., Venturoni, F., Vitagliano, E., Vitali, P., Zappone, A., Zei, E., and Zeoli, M. P.

Subjects
Sleep Initiation and Maintenance Disorder, Male, Time Factors, Healthcare-associated infections, Mortality, Sepsis, Surveillance, Public Health, Environmental and Occupational Health, Infectious Diseases, Diet, Mediterranean, Coffee, Health Statu, Mortality Parole chiave: Infezioni correlate all'assistenza, Mortalità, Sepsi, Sorveglianza, Academic Performance, Prevalence, Surveys and Questionnaire, Hospital Mortality, Prospective Studies, Cross Infection, Incidence, Smoking, Tryptophan, Shock, Middle Aged, Shock, Septic, Intensive Care Units, Italy, Population Surveillance, Female, Public Health, Human, Adult, Employment, Alcohol Drinking, Intensive Care Unit, Regression Analysi, Young Adult, Age Distribution, Learning, Humans, Healthcare-associated infection, Exercise, Life Style, Settore MED/42 - IGIENE GENERALE E APPLICATA, Aged, Cross-Sectional Studie, Septic, Environmental and Occupational Health, Body Weight, Length of Stay, Body Height, Prospective Studie, Quality of Life, Students, Nursing
Abstract

Background. Sepsis is the major cause of mortality from any infectious disease worldwide. Sepsis may be the result of a healthcare associated infection (HAI): the most frequent adverse events during care delivery especially in Intensive Care Units (ICUs). The main aim of the present study was to describe the epidemiology of ICU-acquired sepsis and related outcomes among patients enrolled in the framework of the Italian Nosocomial Infections Surveillance in ICUs - SPIN-UTI project. Study design. Prospective multicenter study. Methods. The SPIN-UTI network adopted the European protocols for patient-based HAI surveillance. Results. During the five editions of the SPIN-UTI project, from 2008 to 2017, 47.0% of HAIs has led to sepsis in 832 patients. Overall, 57.0% episodes were classified as sepsis, 20.5% as severe sepsis and 22.5% as septic shock. The most common isolated microorganisms from sepsis episodes were Acinetobacter baumannii, Klebsiella pneumoniae and Pseudomonas aeruginosa. The case fatality rate increased with the severity of sepsis and the mean length of ICU-stay was significantly higher in patients with ICU-acquired sepsis than in patients without. Conclusions. Our study provides evidence that ICU-acquired sepsis occurs frequently in Italian ICU patients and is associated with a high case fatality rate and increased length of stay. However, in order to explain these findings further analyses are needed in this population of ICU patients.

Published
2018

32. Phenotyping normal kidney function in elderly patients with type 2 diabetes: a cross-sectional multicentre study

Author

Fadini, G. P., Solini, A., Manca, M. L., Zatti, G., Karamouzis, I., Di Benedetto, A., Frittitta, L., Avogaro, A., Consoli, Agostino, Formoso, Gloria, Grossi, Giovanni, Pucci, Achiropita, Sesti, Giorgio, Andreozzi, Francesco, Capobianco, Giuseppe, Gatti, Adriano, Bonadonna, Riccardo, Zavaroni, Ivana, Dei Cas, Alessandra, Felace, Giuseppe, Li Volsi, Patrizia, Buzzetti, Raffaella, Leto, Gaetano, Sorice, Gian Pio, D’Angelo, Paola, Morano, Susanna, Bossi, Antonio Carlo, Duratorre, Edoardo, Franzetti, Ivano, Morpurgo, Paola Silvia, Orsi, Emanuela, Querci, Fabrizio, Boemi, Massimo, D’Angelo, Federica, Petrelli, Massimiliano, Aimaretti, Gianluca, Karamouzis, Ioannis, Cavalot, Franco, Saglietti, Giuseppe, Cazzetta, Giuliana, Cervone, Silvestre, Devangelio, Eleonora, Lamacchia, Olga, Arena, Salvatore, Di Benedetto, Antonino, Frittitta, Lucia, Giordano, Carla, Piro, Salvatore, Rizzo, Manfredi, Chianetta, Roberta, Mannina, Carlo, Anichini, Roberto, Penno, Giuseppe, Solini, Anna, Fattor, Bruno, Bonora, Enzo, Cigolini, Massimo, Lapolla, Annunziata, Chilelli, Nino Cristiano, Poli, Maurizio, Simioni, Natalino, Frison, Vera, Vinci, Carmela, Fadini, G P, Solini, A, Manca, M L, Zatti, G, Karamouzis, I, Di Benedetto, A, Frittitta, L, and Avogaro, A, Giordano, C

Subjects
Male, Epidemiology, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Kidney, Type 2 diabete, Settore MED/13 - Endocrinologia, 0302 clinical medicine, Endocrinology, 80 and over, Medicine, Diabetic Nephropathies, 030212 general & internal medicine, Aged, 80 and over, education.field_of_study, General Medicine, Insulin resistance, Nephropathy, Protective, Diabetes and Metabolism, Phenotype, Lipotoxicity, Female, Type 2, Human, Glomerular Filtration Rate, medicine.medical_specialty, Population, Renal function, Internal Medicine, Diabetes Mellitus, Type 2, Humans, 03 medical and health sciences, Internal medicine, Diabetes mellitus, Diabetes Mellitus, education, Aged, business.industry, medicine.disease, Diabetic Nephropathie, business, Kidney disease
Abstract

AimsType 2 diabetes (T2D) accelerates the decline in glomerular function; however, some individuals do not develop chronic kidney disease despite advanced age and long-lasting T2D. We aimed to phenotype patients with T2D aged 80years or older who presented with a fully preserved kidney function.MethodsFrom an Italian population of 281,217 T2D outpatients, we collected data on demographics, anthropometrics, diabetes duration, HbA1c, fasting plasma glucose, lipids, liver enzymes, estimated glomerular filtration rate (eGFR), albumin excretion rate (AER), chronic complications, and medication use. We primarily compared patients with a fully preserved kidney function (eGFR>90ml/min/1.73m(2) and AER

Published
2018

35. Myoinositol plus α-lactalbumin supplementation, insulin resistance and birth outcomes in women with gestational diabetes mellitus: a randomized, controlled study.

Author

D'Anna, Rosario, Corrado, Francesco, Loddo, Saverio, Gullo, Giuseppe, Giunta, Loretta, and Di Benedetto, Antonino

Subjects
INOSITOL, LACTALBUMIN, INSULIN resistance, GESTATIONAL diabetes, FOLIC acid
Abstract

To verify whether myo-inositol plus α-lactalbumin may reduce insulin resistance and excessive fetal growth in women with gestational diabetes mellitus. In a 12-month period, 120 women with a diagnosis of gestational diabetes mellitus were consecutively enrolled with an allocation of 1:1 in each group and randomly treated with myo-inositol plus α-lactalbumin plus folic acid (treated group) or folic acid (control group) for 2 months. Primary outcome was the variation of insulin resistance through the study evaluated by HOMA-IR. Secondary outcome was the evaluation, through the study, of fetal growth by ultrasound measurements of abdominal circumference centiles and estimated fat thickness. Some clinical outcomes were also considered. After 2 months, in the treated group, a significant reduction in insulin resistance (HOMA values 3.1 ± 1.4 vs 6.1 ± 3.4, p = 0.0002) and fetal growth was shown (Abdominal circumference centiles 54.9 ± 23.5 vs 67.5 ± 22.6, P = 0.006). Among clinical outcomes, a significant decrease in the rate of women who needed insulin (6.7% vs 20.3%, p = 0.03) and of pre-term birth (0 vs 15.2%, p = 0.007) was evidenced. A combination of myo-inositol and α-lactalbumin may reduce insulin resistance and excessive fetal growth. Clinical trial registration: ClinicalTrials.gov, http://www.clinicaltrials.gov, NCT 03763669, first posted date 04/12/2018; last posted date December 06/12/2018. [ABSTRACT FROM AUTHOR]

Published
2021
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37. SCLEROSTIN AND DICKKOPF-1 IN PREGNANT WOMEN WITH GESTATIONAL DIABETES

Author

Catalano, Antonino, Morabito, Nunziata, Bellone, Federica, Pintaudi, B., Giunta, Loretta, Loddo, Saverio, Corrado, Francesco, D'Anna, Rosario, DI BENEDETTO, Antonino, and Lasco, Antonino

Subjects
Dickkopf-1, diabetes, Sclerostin, wnt antagonist, gestational diabetes, pregnant women, Sclerostin, Dickkopf-1, wnt antagonist, pregnant women, gestational diabetes, diabetes
Published
2017

40. Dietary intake and major food sources of polyphenols in people with type 2 diabetes: The TOSCA.IT Study

Author

Vitale, M., Masulli, M., Rivellese, A. A., Bonora, E., Cappellini, F., Nicolucci, Andrea, Squatrito, S., Antenucci, D., Barrea, A., Bianchi, C., Bianchini, F., Fontana, L., Fornengo, P., Giorgino, F., Gnasso, A., Mannucci, E., Mazzotti, A., Nappo, R., Palena, A. P., Pata, P., Perriello, G., Potenziani, S., Radin, R., Ricci, L., Romeo, F., Santini, C., Scarponi, M., Serra, Riccardo, Timi, A., Turco, A. A., Vedovato, M., Zavaroni, D., Grioni, S., Riccardi, G., Vaccaro, O., Rivellese, Angela Albarosa, Cocozza, Sara, Auciello, Stefania, Turco, Anna Amelia, Bonora, Enzo, Cigolini, Massimo, Pichiri, Isabella, Brangani, Corinna, Tomasetto, Elena, Perriello, Gabriele, Timi, Alessia, Squatrito, Sebastiano, Sinagra, Tiziana, Longhitano, Sara, Tropea, Vanessa, Ballardini, Giorgio, Babini, Anna Carla, Ripani, Raffaella, Gregori, Giovanna, Dolci, Maria, Bruselli, Laura, Salutini, Isabella, Mori, Mary, Baccetti, Fabio, Lapolla, Annunziata, Sartore, Giovanni, Burlina, Silvia, Chilelli, Nino Cristiano, Buzzetti, Raffaella, Venditti, Chiara, Potenziani, Stella, Carlone, Angela, Galluzzoâ€&nbsp, Aldo, Giordano, Carla, Torregrossa, Vittoria, Corsi, Laura, Cuneo, Giacomo, Corsi, Simona, Tizio, Biagio, Clemente, Gennaro, Citro, Giuseppe, Natale, Maria, Salvatore, Vita, Di Cianni, Graziano, Lacaria, Emilia, Russo, Laura, Iannarelli, Rossella, de Gregorio, Antonella, Sciarretta, Filomena, D’Andrea, Settimio, Montani, Valeria, Cannarsa, Emanuela, Dolcetti, Katia, Cordera, Renzo, Bonabello, Laura Affinito, Mazzucchelli, Chiara, Giorda, Carlo Bruno, Romeo, Francesco, Bonetto, Caterina, Antenucci, Daniela, Baldassarre, Maria Pompea Antonia, Iovine, Ciro, Nappo, Rossella, Ciano, Ornella, Dall’Aglio, Elisabetta, Mancastroppa, Giovanni, Grimaldi, Franco, Tonutti, Laura, Boemi, Massimo, D’Angelo, Federica, Leotta, Sergio, Fontana, Lucia, Lauro, Davide, Rinaldi, Maria Elena, Cignarelli, Mauro, la Macchia, Olga, Fariello, Stefania, Tomasi, Franco, Zamboni, Chiara, Dozio, Nicoletta, Trevisan, Roberto, Scaranna, Cristiana, Del Prato, Stefano, Miccoli, Roberto, Bianchi, Cristina, Garofolo, Monia, Pugliese, Giuseppe, Salvi, Laura, Rangel, Graziela, Vitale, Martina, Anichini, Roberto, Tedeschi, Anna, Corsini, Elisa, Cucinotta, Domenico, Di Benedetto, Antonino, Giunta, Loretta, Ruffo, Maria Concetta, Bossi, Antonio Carlo, Carpinter, Rita, Dotta, Francesco, Ceccarelli, Elena, Bartolo, Paolo Di, Caselli, Chiara, Luberto, Alessandra, Santini, Costanza, Mazzotti, Arianna, Calbucci, Giovanni, Consoli, Agostino, Ginestra, Federica, Calabrese, Maria, Zogheri, Alessia, Ricci, Lucia, Giorgino, Francesco, Laviola, Luigi, Ippolito, Claudia, Tarantino, Lucia, Avogaro, Angelo, Vedovato, Monica, Gnasso, Agostino, Carallo, Claudio, Scicchitano, Caterina, Zavaroni, Donatella, Livraga, Stefania, Perin, Paolo Cavallo, Forrnengo, Paolo, Prinzis, Tania, de Cosmo, Salvatore, Palena, Antonio Pio, Bacci, Simonetta, Mannucci, Edoardo, Lamanna, Caterina, Pata, Pietro, Lettina, Gabriele, Aiello, Antimo, Barrea, Angelina, Lalli, Carlo, Scarponi, Maura, Franzetti, Ivano, Radin, Raffaella, Serra, Rosalia, Petrachi, Francesca, Asprino, Vincenzo, Capra, Claudio, Forte, Elisa, Reggiani, Giulio Marchesini, Forlani, Gabriele, Montesi, Luca, Mazzella, Natalia, Piatti, Pier Marco, Monti, Lucilla, Stuccillo, Michela, Auletta, Pasquale, Petraroli, Ettore, Capobianco, Giuseppe, Romano, Geremia, Cutolo, Michele, de Simone, Giosetta, Caiazzo, Gennaro, Nunziata, Peppe, Sorrentino, Susy, Amelia, Umberto, Calatola, Pasqualino, Capuano, Gelsomina, Vitale, M, Masulli, M, Rivellese, AA, Bonora, E, Cappellini, F, Nicolucci, A, Squatrito, S, Antenucci, D, Barrea, A, Bianchi, C, Bianchini, F, Fontana, L, Fornengo,P, Giorgino, F, Gnasso, A, Mannucci, Mazzotti, A, Nappo, R, Palena, AP, Pata, P,Perriello, G, Potenziani, S, Radin, R, Ricci, L, Romeo, F, Santini, C, Scarponi, M, Serra, R, Timi, A, Turco, AA, Vedovato, M, Zavaroni, D, Grioni, S, Riccardi, G, Vaccaro, O, TOSCA.IT Study Group., Giordano, C., Rivellese, Aa, Fornengo, P, Mannucci, E, Mazzotti, A, Nappo, R, Palena, Ap, Pata, P, Perriello, G, Turco, Aa, Tosc, A. IT Study Group., Rivellese, A, Palena, A, Turco, A, Cocozza, S, Auciello, S, Cigolini, M, Pichiri, I, Brangani, C, Tomasetto, E, Sinagra, T, Longhitano, S, Tropea, V, Ballardini, G, Babini, A, Ripani, R, Gregori, G, Dolci, M, Bruselli, L, Salutini, I, Mori, M, Baccetti, F, Lapolla, A, Sartore, G, Burlina, S, Chilelli, N, Buzzetti, R, Venditti, C, Carlone, A, Galluzzo, A, Giordano, C, Torregrossa, V, Corsi, L, Cuneo, G, Corsi, S, Tizio, B, Galluzzo, G, Citro, G, Natale, M, Salvatore, V, Di Cianni, G, Lacaria, E, Russo, L, Iannarelli, R, De Gregorio, A, Sciarretta, F, D'Andrea, S, Montani, V, Cannarsa, E, Dolcetti, K, Cordera, R, Bonabello, L, Mazzucchelli, C, Giorda, C, Bonetto, C, Baldassarre, M, Iovine, C, Ciano, O, Dall'Aglio, E, Mancastroppa, G, Grimaldi, F, Tonutti, L, Boemi, M, D'Angelo, F, Leotta, S, Lauro, D, Rinaldi, M, Cignarelli, M, La Macchia, O, Fariello, S, Tomasi, F, Zamboni, C, Dozio, N, Trevisan, R, Scaranna, C, Del Prato, S, Miccoli, R, Garofolo, M, Pugliese, G, Salvi, L, Rangel, G, Anichini, R, Tedeschi, A, Corsini, E, Cucinotta, D, Di Benedetto, A, Giunta, L, Ruffo, M, Bossi, A, Carpinter, R, Dotta, F, Ceccarelli, E, Bartolo, P, Caselli, C, Luberto, A, Calbucci, G, Consoli, A, Ginestra, F, Calabrese, M, Zogheri, A, Laviola, L, Ippolito, C, Tarantino, L, Avogaro, A, Carallo, C, Scicchitano, C, Livraga, S, Perin, P, Forrnengo, P, Prinzis, T, De Cosmo, S, Bacci, S, Lamanna, C, Lettina, G, Aiello, A, Lalli, C, Franzetti, I, Petrachi, F, Asprino, V, Capra, C, Forte, E, Reggiani, G, Forlani, G, Montesi, L, Mazzella, N, Piatti, P, Monti, L, Stuccillo, M, Auletta, P, Petraroli, E, Capobianco, G, Romano, G, Cutolo, M, De Simone, G, Caiazzo, G, Nunziata, P, Sorrentino, S, Amelia, U, Calatola, P, and Capuano, G

Subjects
0301 basic medicine, Male, Age, BMI, Diabetes, Diet, Flavonoids, Food groups, Geographical area, Intake, Phenolic acids, Polyphenols, TOSCA.IT study, Aged, Antioxidants, Beverages, Cinnamates, Cohort Studies, Cross-Sectional Studies, Databases, Factual, Diabetes Mellitus, Type 2, Female, Flavonoids, Fruit, Glycosides, Humans, Italy, Male, Middle Aged, Nutritive Value, Phenols, Polyphenols, Diet, Diabetic, Diet, Healthy, Patient Compliance, Settore MED/09 - Medicina Interna, Databases, Factual, Cross-sectional study, Medicine (miscellaneous), Type 2 diabetes, Diabete, Antioxidants, Settore MED/13 - Endocrinologia, Food group, Cohort Studies, 0302 clinical medicine, Diet, Diabetic, Medicine, Food science, Glycosides, Age, BMI, Diabetes, Diet, Flavonoids, Food groups, Geographical area, Intake, Phenolic acids, Polyphenols, TOSCA.IT study, Nutrition and Dietetics, Phenolic acid, food and beverages, Middle Aged, Polyphenols, Flavonoids, Phenolic acids, Diabetes, Food groups, Diet, Age, BMI, Geographical area, Intake, TOSCA.IT study, Italy, Tosca,Age,BMI,Diabetes,Diet,Flavonoids,Food groups,Geographical area,Intake,Phenolic acids,Polyphenols,TOSCA.IT study, Cohort, Female, Diet, Healthy, Nutritive Value, Cohort study, Polyphenol, 030209 endocrinology & metabolism, Beverages, 03 medical and health sciences, Phenols, Diabetes mellitus, Humans, Aged, 030109 nutrition & dietetics, business.industry, Anthropometry, medicine.disease, Tosca, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Cinnamates, Fruit, Flavonoid, Patient Compliance, business
Abstract

Purpose: Proper evaluation of polyphenols intake at the population level is a necessary step in order to establish possible associations with health outcomes. Available data are limited, and so far no study has been performed in people with diabetes. The aim of this work was to document the intake of polyphenols and their major food sources in a cohort of people with type 2 diabetes and in socio-demographic subgroups. Methods: We studied 2573 men and women aged 50–75 years. Among others, anthropometry was measured by standard protocol and dietary habits were investigated by food frequency questionnaire (EPIC). The intake of polyphenols was evaluated using US Department of Agriculture and Phenol-Explorer databases. Results: The mean total polyphenol intake was 683.3 ± 5.8 mg/day. Non-alcoholic beverages represented the main food source of dietary polyphenols and provided 35.5% of total polyphenol intake, followed by fruits (23.0%), alcoholic beverages (14.0%), vegetables (12.4%), cereal products and tubers (4.6%), legumes (3.7%) and oils (2.1%); chocolate, cakes and nuts are negligible sources of polyphenols in this cohort. The two most important polyphenol classes contributing to the total intake were flavonoids (47.5%) and phenolic acids (47.4%). Polyphenol intake increased with age and education level and decreased with BMI; furthermore, in the northern regions of Italy, the polyphenol intake was slightly, but significantly higher than in the central or southern regions. Conclusions: The study documents for the first time the intake of polyphenols and their main food sources in people with diabetes using validated and complete databases of the polyphenol content of food. Compared with published data, collected in people without diabetes, these results suggest a lower intake and a different pattern of intake in people with diabetes. © 2016 Springer-Verlag Berlin Heidelberg

Published
2016

41. Five-Year Impact of a Continuous Quality Improvement Effort Implemented by a Network of Diabetes Outpatient Clinics

Author

Allotta, G, Allegra, G, Cordaro, G, D'Agati, F, DI BENEDETTO, Antonino, DI MAURO, M, Fulantelli, M, Garofalo, A, Giacchetto, C, Lisi, E, LO PRESTI, N, Lorenti, I, Manunta, M, Mattina, G, Mendola, B, Pata, P, Pellegrini, F, Reina, G, Ridola, G, Runello, F, Saitta, G, Sanfilippo, G, Vaccaro, Mario, and Nicolucci, A.

Subjects
Adult, Research design, medicine.medical_specialty, Quality management, Medical Records Systems, Computerized, Quality Assurance, Health Care, Endocrinology, Diabetes and Metabolism, Blood Pressure, Ambulatory Care Facilities, Diabetes mellitus, Diabetes Mellitus, Internal Medicine, medicine, Humans, Outpatient clinic, Medical prescription, Sicily, Monitoring, Physiologic, Quality Indicators, Health Care, Glycated Hemoglobin, Advanced and Specialized Nursing, medicine.diagnostic_test, business.industry, medicine.disease, Surgery, Treatment Outcome, Blood pressure, Emergency medicine, Microalbuminuria, Lipid profile, business, Software
Abstract

OBJECTIVE—To evaluate the impact of a continuous quality improvement effort implemented by a network of diabetes outpatient clinics in Sicily, Italy. RESEARCH DESIGN AND METHODS—Twenty-two clinics adopted the same electronic medical record system. Process and intermediate outcomes indicators were identified and software was developed, enabling the extraction of the information needed for the profiling of quality of care. Data were centrally analyzed anonymously every year, and results were discussed in meetings with the participants. The performances of the different centers were ranked against the “best performers,” and the reasons for variation were discussed. RESULTS—From 2001 to 2005, a total of 26,782 patients aged ≥18 years have been seen in the participating clinics. Rates of monitoring of A1C, blood pressure, lipid profile, and microalbuminuria constantly increased over the years. The percentage of individuals with A1C values ≤7.0% increased by 16.6%, while the proportion of patients with blood pressure ≤130/85 mmHg increased by 10.7%. The percentage of individuals with LDL cholesterol levels CONCLUSIONS—We found a strong consistency between increasing rates of monitoring, increasing drug prescription, and better levels of intermediate outcomes. Despite the satisfactory achievements, a substantial room for improvement in the care of diabetes still persists.

Published
2008

44. Genistein Supplementation and Cardiac Function in Postmenopausal Women with Metabolic Syndrome: Results from a Pilot Strain-Echo Study

Author

de Gregorio, Cesare, primary, Marini, Herbert, additional, Alibrandi, Angela, additional, Di Benedetto, Antonino, additional, Bitto, Alessandra, additional, Adamo, Elena, additional, Altavilla, Domenica, additional, Irace, Concetta, additional, Di Vieste, Giacoma, additional, Pancaldo, Diego, additional, Granese, Roberta, additional, Atteritano, Marco, additional, Corrao, Salvatore, additional, Licata, Giuseppe, additional, Squadrito, Francesco, additional, and Arcoraci, Vincenzo, additional

Published
2017
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46. Sclerostin in type 1 diabetes mellitus: gender differences and associations with clinical features, bone mass and metabolism

Author

Catalano, Antonino, Morabito, Nunziata, Di Vieste, G, Pintaudi, B, Giunta, Loretta, Bruno, Ml, Cucinotta, Domenico Maria, DI BENEDETTO, Antonino, and Lasco, Antonino

Subjects
bone mass, quantitative ultrasound, diabetes, phalangeal, Sclerostin, gender difference, wnt signalling, Sclerostin, wnt signalling, diabetes, bone turn-over, bone mass, quantitative ultrasound, phalangeal, atherosclerosis, gender difference, atherosclerosis, bone turn-over
Published
2015

47. Metabolic effects of breastfeeding in women with previous gestational diabetes diagnosed according to the IADPSG criteria.

Author

Corrado, Francesco, Giunta, Loretta, Granese, Roberta, Corrado, Silvia, Micali, Marina, Santamaria, Angelo, D’Anna, Rosario, and Di Benedetto, Antonino

Subjects
BREASTFEEDING, GESTATIONAL diabetes, GLUCOSE tolerance tests, TRIGLYCERIDES, INSULIN resistance, FASTING
Abstract

Background: Some studies have already investigated about the short-term favorable metabolic effects of breastfeeding in women with previous gestational diabetes mellitus (GDM). Aim: The aim of our study is to confirm whether the positive effects reported are maintained in the larger cohorts of patients with mild form of gestational diabetes mellitus (GDM) because recently diagnosed according to IADPSG criteria. Materials and methods: This retrospective study includes 97 evaluable consecutive women with prior GDM who have the follow-up oral glucose tolerance test at least 3 months after delivery. Fasting and 2-h plasma glucose values, homeostasis model assessment (HOMA-IR), total cholesterol, and triglycerides were obtained in pregnancy and during the post-partum control. Results: These patients were divided in 81 (83.5%) who lactate until 3 months and 16 (16.5%) who did not lactate. During pregnancy, there are no significant differences between the two groups for age, BMI, fasting and 2-h plasma glucose values, HOMA-IR, total cholesterol and triglycerides. At the postpartum control, we have at univariate analysis significant differences for all these parameters except total cholesterol. After adjustment for confounders we still have, in the breastfeeding group, HOMA-IR reduction (OR 0.370; 95% CI 0.170-0.805; p < .01) as significant independent variable, whose improvement is the most acknowledged important factor for the prevention of abnormal glucose tolerance later in life. Conclusion: These encouraging results confirm our determination to warmly advice the women affected by GDM to breastfeeding at least for 3 months. [ABSTRACT FROM AUTHOR]

Published
2019
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50. Plasma, Erythrocyte and Platelet Magnesium Levels in Type 1 Diabetic Patients with Microalbuminuria and Clinical Proteinuria

Author

Allegra, Alessandro, Corsonello, A, Buemi, Michele, D'Angelo, R, Ientile, Riccardo, DI BENEDETTO, Antonino, Corica, Francesco, Bonanzinga, S, Cucinotta, Domenico Maria, Cucinotta, D, Ientile, R, and Corica, F.

Subjects
Adult, Blood Platelets, Male, insulin-dependent diabetes mellitus, medicine.medical_specialty, Erythrocytes, microalbuminuria, endocrine system diseases, chemistry.chemical_element, Biochemistry, Inorganic Chemistry, Reference Values, Diabetes mellitus, Internal medicine, Albuminuria, Humans, Medicine, Magnesium, Platelet, In patient, platelet, Glycated Hemoglobin, Proteinuria, business.industry, Healthy subjects, nutritional and metabolic diseases, medicine.disease, Endocrinology, chemistry, Regression Analysis, Molecular Medicine, Female, Microalbuminuria, medicine.symptom, business
Abstract

We evaluated plasma, erythrocyte and platelet magnesium levels in patients with insulin-dependent diabetes mellitus (IDDM) with normoalbuminuria (N = 10), microalbuminuria (N = 10), and clinical proteinuria (N = 7), and in a group of healthy subjects (N = 10). We found that IDDM patients had lower platelet magnesium levels when compared to controls. Lower platelet magnesium concentrations were found in patients with microalbuminuria (1.859 +/- 0.47 vs 2.340 +/- 0.46 mumol/10(8) cells, p0.05) and in those with clinical proteinuria (1.522 +/- 0.19 vs 2.340 +/- 0.46 mumol/10(8) cells, p0.01) with respect to the group with normoalbuminuria. In the groups with microalbuminuria and clinical proteinuria we detected a negative correlation between HbA1c and both plasma and platelet magnesium. Our findings indicate that microalbuminuria and clinical proteinuria are associated with an altered magnesium homeostasis. In particular, decreased platelet magnesium concentrations could represent an additional risk factor in the pathogenesis of microvascular complications of diabetes.

Published
1997

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