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Objective: In this study, the aim was to evaluate the effect of metabolic syndrome (MetS) and criteria on the diagnosis of prostate cancer (PCa) in patients with a prostate-specific antigen (PSA) value of 2.5-4 ng/mL. Materials and Methods: A total of 116 patients who underwent transrectal ultrasound-guided prostate biopsy between January 2016-June 2018 with a PSA value of 2.5-4 ng/mL were included in the study. Patient height, body weight, waist circumference (WC) and blood pressure were measured and body mass indexes were calculated. Blood samples were also collected and tested for fasting and postprandial blood glucose, along with lipid profiles. Patients were divided into two groups as those with and without PCa. The presence of MetS was evaluated according to the measurements and laboratory results. Results: Patients were divided into two groups as those without PCa (n=101) and those with PCa (n=15). A significant difference was found between the groups in terms of the frequency of hypertension (p=0.024). There were no significant differences between the groups in terms of other demographic characteristics. There was a significant difference between the groups in terms of hypertension, a criterion for MetS. The presence of MetS and other MetS criteria (WC >102 cm, triglyceride ≥150 mg/dL, high density lipoprotein <40 mg/dL, fasting blood glucose ≥110 mg/dL or type 2 diabetes mellitus) was not associated with PCa in patients with PSA levels of 2.5-4 ng/mL. Conclusions: Among the MetS criteria, there was only a positive relationship between hypertension and PCa in patients with PSA 2.5-4 ng/mL. [ABSTRACT FROM AUTHOR]

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