1. T-Cell Adhesion in Healthy and Inflamed Skin
- Author
-
Michael Rosenblum, Victoire Gouirand, and Joshua M. Moreau
- Subjects
regulatory T cell ,HF ,Trm ,DETC ,Review ,DC ,progressive multifocal leukoencephalopathy ,Extracellular matrix ,DC, dendritic cell ,Th ,2.1 Biological and endogenous factors ,Aetiology ,Skin ,atopic dermatitis ,hair follicle ,biology ,Cell adhesion molecule ,HF, hair follicle ,leukocyte adhesion deficiency ,Adhesion ,Cell biology ,ECM, extracellular matrix ,Treg ,medicine.anatomical_structure ,RL1-803 ,Selectin ,dendritic cell ,Regulatory T cell ,LAD, leukocyte adhesion deficiency ,extracellular matrix ,1.1 Normal biological development and functioning ,Integrin ,JC ,tissue-resident memory ,Treg, regulatory T cell ,dendritic epidermal γδ T cell ,Dermatology ,BM ,Underpinning research ,PML, progressive multifocal leukoencephalopathy ,T helper ,medicine ,DETC, dendritic epidermal γδ T cell ,Th, T helper ,Leukocyte adhesion deficiency ,ECM ,LAD ,PML ,Inflammatory and immune system ,AD ,Dendritic cell ,Trm, tissue-resident memory ,AD, atopic dermatitis ,medicine.disease ,basement membrane ,JC, John Cunningham ,BM, basement membrane ,John Cunningham ,biology.protein - Abstract
The diverse populations of tissue-resident and transitory T cells present in the skin share a common functional need to enter, traverse, and interact with their environment. These processes are largely dependent on the regulated expression of adhesion molecules, such as selectins and integrins, which mediate bidirectional interactions between immune cells and skin stroma. Dysregulation and engagement of adhesion pathways contribute to ectopic T-cell activity in tissues, leading to the initiation and/or exacerbation of chronic inflammation. In this paper, we review how the molecular interactions supported by adhesion pathways contribute to T-cell dynamics and function in the skin. A comprehensive understanding of the molecular mechanisms underpinning T-cell adhesion in inflammatory skin disorders will facilitate the development of novel tissue-specific therapeutic strategies.
- Published
- 2021