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2. Urine soluble TLR4 levels may contribute to predict urinary tract infection in children: the UTILISE Study

Author

Aksu, Bagdagul, Afonso, Alberto Caldas, Akil, Ipek, Alpay, Harika, Atmis, Bahriye, Aydog, Ozlem, Bayazıt, Aysun Karabay, Bayram, Meral Torun, Bilge, Ilmay, Bulut, Ipek Kaplan, Buyukkaragoz, Bahar, Comak, Elif, Demir, Belde Kasap, Dincel, Nida, Donmez, Osman, Durmus, Mehmet Akif, Dursun, Hasan, Dusunsel, Ruhan, Duzova, Ali, Ertan, Pelin, Gedikbasi, Asuman, Goknar, Nilufer, Guven, Sercin, Hacihamdioglu, Duygu, Jankauskiene, Augustina, Kalyoncu, Mukaddes, Kavukcu, Salih, Kenan, Bahriye Uzun, Kucuk, Nuran, Kural, Bahar, Litwin, Mieczysław, Montini, Giovanni, Morello, William, Obrycki, Lukasz, Omer, Beyhan, Oner, Huseyin Adil, Ozdemir, Ebru Misirli, Ozkayin, Nese, Paripovic, Dusan, Pehlivanoglu, Cemile, Saygili, Seha, Schaefer, Franz, Schaefer, Susanne, Sonmez, Ferah, Tabel, Yilmaz, Tas, Nesrin, Tasdemir, Mehmet, Teixeira, Ana, Tekcan, Demet, Topaloglu, Rezan, Tulpar, Sebahat, Turkkan, Ozde Nisa, Uysal, Berfin, Uysalol, Metin, Vitkevic, Renata, Yavuz, Sevgi, Yel, Sibel, Yildirim, Tarik, Yildirim, Zeynep Yuruk, Yildiz, Nurdan, Yuksel, Selcuk, Yurtseven, Eray, and Yilmaz, Alev

Published
2024
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3. Urinary HSP70 improves diagnostic accuracy for urinary tract infection in children: UTILISE study

Author

Yilmaz, Alev, Afonso, Alberto Caldas, Akil, Ipek, Aksu, Bagdagul, Alpay, Harika, Atmis, Bahriye, Aydog, Ozlem, Bayazıt, Aysun Karabay, Bayram, Meral Torun, Bilge, Ilmay, Bulut, Ipek Kaplan, Buyukkaragoz, Bahar, Comak, Elif, Demir, Belde Kasap, Dincel, Nida, Donmez, Osman, Durmus, Mehmet Akif, Dursun, Hasan, Dusunsel, Ruhan, Duzova, Ali, Ertan, Pelin, Gedikbasi, Asuman, Goknar, Nilufer, Guven, Sercin, Hacihamdioglu, Duygu, Jankauskiene, Augustina, Kalyoncu, Mukaddes, Kavukcu, Salih, Kenan, Bahriye Uzun, Kucuk, Nuran, Kural, Bahar, Litwin, Mieczysław, Montini, Giovanni, Morello, William, Nayir, Ahmet, Obrycki, Lukasz, Omer, Beyhan, Ozdemir, Ebru Misirli, Ozkayin, Nese, Paripovic, Dusan, Pehlivanoglu, Cemile, Saygili, Seha, Schaefer, Susanne, Sonmez, Ferah, Tabel, Yilmaz, Tas, Nesrin, Tasdemir, Mehmet, Teixeira, Ana, Tekcan, Demet, Tulpar, Sebahat, Turkkan, Ozde Nisa, Uysal, Berfin, Uysalol, Metin, Vaiciuniene, Daiva, Yavuz, Sevgi, Yel, Sibel, Yildirim, Tarik, Yildirim, Zeynep Yuruk, Yildiz, Nurdan, Yuksel, Selcuk, Yurtseven, Eray, Schaefer, Franz, and Topaloglu, Rezan

Published
2023
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4. A surprising cause of proteinuria: Answers

Author

Demir, Belde Kasap, Kanik, Ali, Köse, Melis, Hismi, Burcu Öztürk, and Baran, Masallah

Subjects
Proteinuria -- Diagnosis -- Case studies -- Risk factors, Diagnosis, Differential -- Case studies, Macrophage colony stimulating factor -- Case studies -- Health aspects, Systemic lupus erythematosus -- Complications and side effects -- Case studies, Health
Abstract

Author(s): Belde Kasap Demir [sup.1] [sup.2] , Ali Kanik [sup.2] [sup.3] , Melis Köse [sup.2] [sup.4] , Burcu Öztürk Hismi [sup.5] , Masallah Baran [sup.2] [sup.6] Author Affiliations: (1) grid.411795.f, [...]

Published
2022
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6. Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis on anti-interleukin-1 or -6 therapy.

Author

Ulu, Kadir, Aliyev, Emil, Könte, Elif Kılıç, Tanatar, Ayşe, Türkmen, Şeyma, Doğantan, Şeyda, Kızıldağ, Zehra, Demir, Belde Kasap, Yıldırım, Deniz Gezgin, Yener, Gülçin Otar, Öztürk, Kübra, Baba, Özge, Açarı, Ceyhun, Kılbaş, Gülşah, Taşkın, Sema Nur, Haşlak, Fatih, Çağlayan, Şengül, Bağlan, Esra, Dundar, Hatice Adıgüzel, and Başaran, Özge

Subjects
BIOTHERAPY, CROSS-sectional method, JUVENILE idiopathic arthritis, PLATELET count, FERRITIN, DISEASE duration, SCIENTIFIC observation, ANTIRHEUMATIC agents, CHILDREN'S hospitals, RETROSPECTIVE studies, BLOOD sedimentation, FEVER, DRUG efficacy, RESEARCH, MEDICAL records, ACQUISITION of data, MACROPHAGE activation syndrome, CELL receptors, INTERLEUKINS, C-reactive protein, PHARMACODYNAMICS, CHEMICAL inhibitors
Abstract

Objectives The aim of this study is to investigate the effect of anti-interleukin (IL)-1/-6 biologics on systemic juvenile idiopathic arthritis (sJIA)-associated macrophage activation syndrome (MAS). Methods Demographic, clinical and laboratory data of patients followed up with a diagnosis of sJIA-associated MAS assessed from sixteen paediatric rheumatology centres across the country. The clinical and laboratory features of MAS developing while on biological drugs were compared with those without this treatment. Results One hundred and sixty-two patients were included in the study. Forty-five of the MAS events were detected under the effect of anti-IL-1/-6 biologics, while the patients experiencing the remaining 155 events have not received biological treatment in the last three months. Platelet count [128 (72–232) vs 199 (130–371) 109/l], ferritin level on admission [1107 (676–2050) vs 2863 (1193–9562) ng/ml], C-reactive protein level [15.4 (2.9–56) vs 90 (32–160) mg/l], erythrocyte sedimentation rate [13 (3–36) vs 43.5 (13–77) mm/h] and fever duration [5 (4–7.5) vs 10 (7–14.3) days] were found lower in the group under the impact of anti-IL-1/-6 biologics. Among patients treated with biologics, 26.6% did not meet the published 2016 MAS classification criteria at presentation. The rates of hepatomegaly and splenomegaly were relatively lower in the canakinumab-treated group when compared with those receiving other biologicals or to patients, not on biologicals. Conclusion Anti-IL-1/-6 therapies can mask the clinical and laboratory features of MAS, and proposed guidelines for MAS classification criteria may not be met. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Nephrological Follow-up of Children Victims of The Earthquake: A Single Center Experience.

Author

Başaran, Cemaliye, Şimşek, Özgür Özdemir, Alaygut, Demet, Çamlar, Seçil Arslansoyu, Mutlubaş, Fatma, Anıl, Ayşe Berna, and Demir, Belde Kasap

Subjects
ACUTE kidney failure, CHILD patients, CRUSH syndrome, CREATINE kinase, EARTHQUAKES
Abstract

Copyright of Journal of Behcet Uz Children's Hospital is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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8. The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study

Author

Aksu, Bagdagul, primary, Afonso, Alberto Caldas, additional, Akil, Ipek, additional, Alpay, Harika, additional, Atmis, Bahriye, additional, Aydog, Ozlem, additional, Bakkaloglu, Sevcan, additional, Bayazıt, Aysun Karabay, additional, Bayram, Meral Torun, additional, Bilge, Ilmay, additional, Bulut, Ipek Kaplan, additional, Cetinkaya, Ayse Pinar Goksu, additional, Comak, Elif, additional, Demir, Belde Kasap, additional, Dincel, Nida, additional, Donmez, Osman, additional, Durmus, Mehmet Akif, additional, Dursun, Hasan, additional, Dusunsel, Ruhan, additional, Duzova, Ali, additional, Ertan, Pelin, additional, Gedikbasi, Asuman, additional, Goknar, Nilufer, additional, Guven, Sercin, additional, Hacihamdioglu, Duygu, additional, Jankauskiene, Augustina, additional, Kalyoncu, Mukaddes, additional, Kavukcu, Salih, additional, Kenan, Bahriye Uzun, additional, Kucuk, Nuran, additional, Kural, Bahar, additional, Litwin, Mieczysław, additional, Montini, Giovanni, additional, Morello, William, additional, Obrycki, Lukasz, additional, Omer, Beyhan, additional, Misirli Ozdemir, Ebru, additional, Ozkayin, Nese, additional, Paripovic, Dusan, additional, Pehlivanoglu, Cemile, additional, Saygili, Seha, additional, Schaefer, Franz, additional, Schaefer, Susanne, additional, Sonmez, Ferah, additional, Tabel, Yilmaz, additional, Tas, Nesrin, additional, Tasdemir, Mehmet, additional, Teixeira, Ana, additional, Tekcan, Demet, additional, Topaloglu, Rezan, additional, Tulpar, Sebahat, additional, Turkkan, Ozde Nisa, additional, Uysal, Berfin, additional, Uysalol, Metin, additional, Vitkevic, Renata, additional, Yavuz, Sevgi, additional, Yel, Sibel, additional, Yildirim, Tarik, additional, Yildirim, Zeynep Yuruk, additional, Yildiz, Nurdan, additional, Yuksel, Selcuk, additional, Yurtseven, Eray, additional, and Yilmaz, Alev, additional

Published
2024
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9. Pediatric kidney care experience after the 2023 Türkiye earthquake

Author

Bakkaloğlu, Sevcan A, primary, Delibaş, Ali, additional, Sürmeli Döven, Serra, additional, Taner, Sevgin, additional, Yavuz, Sevgi, additional, Erfidan, Gökçen, additional, Danacı Vatansever, Esra, additional, Aynacı, Fatma, additional, Yilmaz, Kenan, additional, Taşdemir, Mehmet, additional, Akacı, Okan, additional, Akıncı, Nurver, additional, Güven, Serçin, additional, Çiçek, Neslihan, additional, Dursun, Ismail, additional, Keleşoğlu, Emre, additional, Sancaktar, Muhammet, additional, Alaygut, Demet, additional, Saygılı, Seha, additional, Yavaşcan, Önder, additional, Yılmaz, Alev, additional, Gülleroğlu, Kaan, additional, Ertan, Pelin, additional, Demir, Belde Kasap, additional, Poyrazoğlu, Hakan, additional, Pınarbaşı, Seda, additional, Gençler, Aylin, additional, Baştuğ, Funda, additional, Günay, Neslihan, additional, Çeleğen, Kübra, additional, Noyan, Aytül, additional, Parmaksız, Gönül, additional, Avcı, Begüm, additional, Çaycı, Fatma Şemsa, additional, Bayrakçı, Umut, additional, Özlü, Sare Gülfem, additional, Aksoy, Özlem Yüksel, additional, Yel, Sibel, additional, İnal, Güldane Aylin, additional, Köse, Seçil, additional, Bayazıt, Aysun Karabay, additional, Atmış, Bahriye, additional, Sarıbaş, Emel, additional, Çağlı, Çağla, additional, Tabel, Yılmaz, additional, Elmas, Ahmet Taner, additional, Zırhlı Selçuk, Şenay, additional, Demircioğlu Kılıç, Beltinge, additional, Akbalık Kara, Mehtap, additional, Büyükçelik, Mithat, additional, Balat, Ayşe, additional, Durucu Tiryaki, Betül, additional, Erdoğdu, Bilge, additional, Aksu, Bağdagül, additional, Mahmudova, Günay, additional, Dursun, Hasan, additional, Candan, Cengiz, additional, Göknar, Nilüfer, additional, Mutlubaş, Fatma, additional, Çamlar, Seçil Arslansoyu, additional, Başaran, Cemaliye, additional, Akbulut, Burcu Bulum, additional, Düzova, Ali, additional, Gülhan, Bora, additional, Oruç, Çiğdem, additional, Peru, Harun, additional, Alpay, Harika, additional, Türkkan, Özde Nisa, additional, Gülmez, Rüveyda, additional, Çelakıl, Mehtap, additional, Doğan, Kenan, additional, Bilge, Ilmay, additional, Pehlivanoğlu, Cemile, additional, Büyükkaragöz, Bahar, additional, Leventoğlu, Emre, additional, Alpman, Nuray, additional, Zeybek, Cengiz, additional, Tülpar, Sebahat, additional, Çiçek Gülşan, Rümeysa Yasemin, additional, Kara, Aslıhan, additional, Gürgöze, Metin Kaya, additional, Akyol Önder, Esra Nagehan, additional, Özdemir Atikel, Yeşim, additional, Pul, Serim, additional, Sönmez, Ferah, additional, Yıldız, Gizem, additional, Akman, Sema, additional, Elmacı, Midhat, additional, Küçük, Nuran, additional, Yüksel, Selçuk, additional, Kavaz, Aslı, additional, Nalçacıoğlu, Hülya, additional, Alparslan, Caner, additional, Dinçel, Nida, additional, Elhan, Atilla H, additional, and Sever, Lale, additional

Published
2024
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10. What does acute kidney injury and dark red-brown urine that appear after bone marrow transplantation tell us: Answers

Author

Alaygut, Demet, Erfidan, Gökçen, Soyaltin, Eren, Sivis, Zuhal Önder, Çamlar, Seçil Arslansoyu, Mutlubas, Fatma, and Demir, Belde Kasap

Subjects
Acute renal failure -- Diagnosis -- Risk factors, Urine -- Health aspects -- Optical properties -- Composition, Pediatric research, Hemoglobinuria, Paroxysmal -- Complications and side effects, Health
Abstract

Author(s): Demet Alaygut [sup.1] , Gökçen Erfidan [sup.1] , Eren Soyaltin [sup.1] , Zuhal Önder Sivis [sup.2] , Seçil Arslansoyu Çamlar [sup.1] , Fatma Mutlubas [sup.1] , Belde Kasap Demir [...]

Published
2021
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11. A diagnostic dilemma in a child with macroscopic hematuria, nephrotic syndrome and hypocomplementemia: Answers

Author

Soyaltin, Eren, Camlar, Sesil Arslansoyu, Alaygut, Demet, Mutlubas, Fatma, Yavascan, Onder, Solakoglu, Seyhun, and Demir, Belde Kasap

Subjects
Children -- Diseases, Kidney diseases -- Diagnosis, Pediatric research, Health
Abstract

Author(s): Eren Soyaltin [sup.1] , Seçil Arslansoyu Çamlar [sup.1] , Demet Alaygut [sup.1] , Fatma Mutlubas [sup.1] , Önder Yavascan [sup.1] , Seyhun Solakoglu [sup.2] , Belde Kasap Demir [sup.1] [...]

Published
2020
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18. A dilemma of proximal tubule in an infant: hypophosphatemia and hypouricemia without hypokalemia and acidosis: Answers

Author

Soyaltin, Eren, Demir, Belde Kasap, Erfidan, Gökçen, Çamlar, Seçil Arslansoyu, Alaygut, Demet, and Mutlubas, Fatma

Subjects
Uric acid -- Health aspects, Ifosfamide -- Complications and side effects, Infants -- Drug therapy, Kidney tubules -- Health aspects, Kidney diseases -- Diagnosis -- Drug therapy, Pediatric research, Hypophosphatemia -- Causes of, Health
Abstract

Author(s): Eren Soyaltin [sup.1] , Belde Kasap Demir [sup.1] [sup.2] , Gökçen Erfidan [sup.1] , Seçil Arslansoyu Çamlar [sup.1] , Demet Alaygut [sup.1] , Fatma Mutlubas [sup.1] Author Affiliations: (1) [...]

Published
2020
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19. Pediatric cases diagnosed with drug-related acute tubulointerstitial nephritis: a single-center experience.

Author

Şimşek, Özgür Özdemir, Erfidan, Gökçen, Alparslan, Caner, Başaran, Cemaliye, Çamlar, Seçil Arslansoyu, Mutlubaş, Fatma, Demir, Belde Kasap, and Alaygut, Demet

Subjects
TUBULOINTERSTITIAL nephritis & uveitis syndrome, ACUTE kidney failure, KIDNEY disease diagnosis, URINARY incontinence, BIOPSY
Abstract

Copyright of Ege Journal of Medicine is the property of Ege University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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20. Urine soluble TLR4 levels may contribute to predict urinary tract infection in children: the UTILISE Study

Author

Aksu, Bagdagul, primary, Afonso, Alberto Caldas, additional, Akil, Ipek, additional, Alpay, Harika, additional, Atmis, Bahriye, additional, Aydog, Ozlem, additional, Bayazıt, Aysun Karabay, additional, Bayram, Meral Torun, additional, Bilge, Ilmay, additional, Bulut, Ipek Kaplan, additional, Buyukkaragoz, Bahar, additional, Comak, Elif, additional, Demir, Belde Kasap, additional, Dincel, Nida, additional, Donmez, Osman, additional, Durmus, Mehmet Akif, additional, Dursun, Hasan, additional, Dusunsel, Ruhan, additional, Duzova, Ali, additional, Ertan, Pelin, additional, Gedikbasi, Asuman, additional, Goknar, Nilufer, additional, Guven, Sercin, additional, Hacihamdioglu, Duygu, additional, Jankauskiene, Augustina, additional, Kalyoncu, Mukaddes, additional, Kavukcu, Salih, additional, Kenan, Bahriye Uzun, additional, Kucuk, Nuran, additional, Kural, Bahar, additional, Litwin, Mieczysław, additional, Montini, Giovanni, additional, Morello, William, additional, Obrycki, Lukasz, additional, Omer, Beyhan, additional, Oner, Huseyin Adil, additional, Ozdemir, Ebru Misirli, additional, Ozkayin, Nese, additional, Paripovic, Dusan, additional, Pehlivanoglu, Cemile, additional, Saygili, Seha, additional, Schaefer, Franz, additional, Schaefer, Susanne, additional, Sonmez, Ferah, additional, Tabel, Yilmaz, additional, Tas, Nesrin, additional, Tasdemir, Mehmet, additional, Teixeira, Ana, additional, Tekcan, Demet, additional, Topaloglu, Rezan, additional, Tulpar, Sebahat, additional, Turkkan, Ozde Nisa, additional, Uysal, Berfin, additional, Uysalol, Metin, additional, Vitkevic, Renata, additional, Yavuz, Sevgi, additional, Yel, Sibel, additional, Yildirim, Tarik, additional, Yildirim, Zeynep Yuruk, additional, Yildiz, Nurdan, additional, Yuksel, Selcuk, additional, Yurtseven, Eray, additional, and Yilmaz, Alev, additional

Published
2023
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33. Assessing fatigue and related factors in adolescents with familial Mediterranean fever (FMF): psychometric properties of the PedsQL Multidimensional Fatigue Scale.

Author

Saraç, Devrim Can, Metin, Serkan, Demir, Belde Kasap, Gücenmez, Özge Altuğ, İnanç, İsrafil, Akar, İdil, Karakurt, Cennet Hanım, Kongur, Sena, Pastutmaz, Ece, and Bayraktar, Deniz

Abstract

Background. Fatigue is a common problem in pediatric rheumatic diseases and is associated with poor quality of life. However, no validated methods are available to measure fatigue in adolescents with familial Mediterranean fever (FMF). The aim of the study was to establish validity and reliability for the child self-report PedsQL Multidimensional Fatigue Scale (PedsQL-MFS) and to investigate the effects of physical characteristics, diseaserelated characteristics, sleep quality/duration, and the amount of physical activity on fatigue in adolescents with FMF. Methods. Seventy-one adolescents with FMF (13-18 years) were included. Children were examined regarding physical- and disease-related characteristics and completed patient-reported outcome measures (PROMs) regarding sleep quality/duration, physical activity levels, and fatigue. PedsQL-MFS was re-completed within the following 7-14 days. Results. PedsQL-MFS demonstrated excellent test-retest reliability (ICC in 95% CI: 0.877-0.958) and internal consistency (Cronbach's α: 0.928). All items contributed to the total score (item-total correlation >0.3). PedsQLMFS scores were significantly correlated to fatigue (r: -0.666, p<0.001), physical activity (r: 0.373, p<0.001), sleep quality (rs: 0.678, p<0.001), and sleep duration (r: 0.473, p<0.001). Being female, having attacks in the last six months, a sleep duration of less than seven hours, and engaging in less physical activity resulted in higher fatigue. Conclusions. PedsQL-MFS seems to be feasible for assessing fatigue in adolescents with FMF. Sex, recent attacks, sleep, and physical activity should be taken into consideration in the fatigue management of patients with FMF. [ABSTRACT FROM AUTHOR]

Published
2023
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34. The outcomes of renin-angiotensin-aldosterone system inhibition and immunosuppressive therapy in children with X-linked Alport syndrome.

Author

Özdemir, Gülşah, Gülhan, Bora, Şükür, Eda Didem Kurt, Atayar, Emine, Atan, Raziye, Dursun, İsmail, Özçakar, Zeynep Birsin, Saygılı, Seha, Soylu, Alper, Söylemezoğlu, Oğuz, Yılmaz, Alev, Bayazıt, Aysun Karabay, Eroğlu, Fehime Kara, Demir, Belde Kasap, Yüksel, Selçuk, Tabel, Yılmaz, Ağbaş, Ayşe, Düzova, Ali, Hayran, Mutlu, and Özaltın, Fatih

Abstract

Background. Alport syndrome (AS) is characterized by progressive kidney disease. There is increasing evidence that renin-angiotensin-aldosterone system (RAAS) inhibition delays chronic kidney disease (CKD) while the effectiveness of immunosuppressive (IS) therapy in AS is still uncertain. In this study, we aimed to analyze the outcomes of pediatric patients with X-linked AS (XLAS) who received RAAS inhibitors and IS therapy. Methods. Seventy-four children with XLAS were included in this multicenter study. Demographic features, clinical and laboratory data, treatments, histopathological examinations, and genetic analyses were analyzed retrospectively. Results. Among 74 children, 52 (70.2%) received RAAS inhibitors, 11 (14.9%) received RAAS inhibitors and IS, and 11 (14.9%) were followed up without treatment. During follow-up, glomerular filtration rate (GFR) decreased <60 ml/min/1.73 m2 in 7 (9.5%) of 74 patients (M/F=6/1). In male patients with XLAS, kidney survival was not different between RAAS and RAAS+IS groups (p=0.42). The rate of progression to CKD was significantly higher in patients with nephrotic range proteinuria and nephrotic syndrome (NS), respectively (p=0.006, p=0.05). The median age at the onset of RAAS inhibitors was significantly higher in male patients who progressed to CKD (13.9 vs 8.1 years, p=0.003). Conclusions. RAAS inhibitors have beneficial effects on proteinuria and early initiation of therapy may delay the progression to CKD in children with XLAS. There was no significant difference between the RAAS and RAAS+IS groups in kidney survival. AS patients presenting with NS or nephrotic range proteinuria should be followed up more carefully considering the risk of early progression to CKD. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Urinary HSP70 improves diagnostic accuracy for urinary tract infection in children: UTILISE study

Author

Yilmaz, Alev, primary, Afonso, Alberto Caldas, additional, Akil, Ipek, additional, Aksu, Bagdagul, additional, Alpay, Harika, additional, Atmis, Bahriye, additional, Aydog, Ozlem, additional, Bayazıt, Aysun Karabay, additional, Bayram, Meral Torun, additional, Bilge, Ilmay, additional, Bulut, Ipek Kaplan, additional, Buyukkaragoz, Bahar, additional, Comak, Elif, additional, Demir, Belde Kasap, additional, Dincel, Nida, additional, Donmez, Osman, additional, Durmus, Mehmet Akif, additional, Dursun, Hasan, additional, Dusunsel, Ruhan, additional, Duzova, Ali, additional, Ertan, Pelin, additional, Gedikbasi, Asuman, additional, Goknar, Nilufer, additional, Guven, Sercin, additional, Hacihamdioglu, Duygu, additional, Jankauskiene, Augustina, additional, Kalyoncu, Mukaddes, additional, Kavukcu, Salih, additional, Kenan, Bahriye Uzun, additional, Kucuk, Nuran, additional, Kural, Bahar, additional, Litwin, Mieczysław, additional, Montini, Giovanni, additional, Morello, William, additional, Nayir, Ahmet, additional, Obrycki, Lukasz, additional, Omer, Beyhan, additional, Ozdemir, Ebru Misirli, additional, Ozkayin, Nese, additional, Paripovic, Dusan, additional, Pehlivanoglu, Cemile, additional, Saygili, Seha, additional, Schaefer, Susanne, additional, Sonmez, Ferah, additional, Tabel, Yilmaz, additional, Tas, Nesrin, additional, Tasdemir, Mehmet, additional, Teixeira, Ana, additional, Tekcan, Demet, additional, Tulpar, Sebahat, additional, Turkkan, Ozde Nisa, additional, Uysal, Berfin, additional, Uysalol, Metin, additional, Vaiciuniene, Daiva, additional, Yavuz, Sevgi, additional, Yel, Sibel, additional, Yildirim, Tarik, additional, Yildirim, Zeynep Yuruk, additional, Yildiz, Nurdan, additional, Yuksel, Selcuk, additional, Yurtseven, Eray, additional, Schaefer, Franz, additional, and Topaloglu, Rezan, additional

Published
2022
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36. Comparison of clinically related factors and treatment approaches in patients with acute bronchiolitis

Author

Üzüm, Özlem, Kanık, Ali, Eliaçık, Kayı, Hortu, Hacer Örsdemir, Demirçelik, Yavuz, Yan, Mehmet, Helvacı, Mehmet, and Demir, Belde Kasap

Subjects
rhinovirus, salbutamol, steroid, Bronchiolitis, Original Article / Özgün Araştırma
Abstract

Acute bronchiolitis is a lower respiratory tract infection caused by viral agents in children aged under two years. Treatment includes hydration, oxygen, nebulized salbutamol, and intravenous steroids. This study aimed to determine the clinically related factors, the effect of viral agents on the clinical picture, and the efficacy of treatment methods in patients admitted with acute bronchiolitis.Patients aged under two years of age who were hospitalized with a diagnosis of moderate/severe acute bronchiolitis between March 2015 and March 2019 were included in the study. Demographic data, hospitalization time, body temperature, presence of congenital heart disease, history of atopy, acute-phase reactants, mean platelet volume values, and respiratory virus panel results were recorded. The treatment modalities, length of hospitalization, intensive care hospitalization, and high-flow nasal cannula oxygen therapy (HFNC) were recorded.Four hundred twenty-two patients were included in the study. The duration of hospitalization was found to be significantly longer in patients aged under one year and in patients with acyanotic congenital heart disease. A single viral agent was detected in 69 (51.9%) patients. Rhinovirus was detected in 70 patients and RSV was detected in 37. The duration of hospitalization was found to be significantly shorter in patients who received only oxygen and/or intravenous fluid treatment compared with those who received nebulized salbutamol and/or intravenous steroids. In addition, and there was no significant difference between the groups in terms of HFNC and hospitalization in the intensive care unit.Rhinovirus was the most common cause of acute bronchiolitis in our study. It was observed that congenital heart disease prolonged the length of hospitalization. In the treatment approaches, it was observed that hydration and oxygen therapy were sufficient treatment methods for the patients, in accordance with the recommendations of the American Academy of Pediatrics, and giving nebulized therapy prolonged the hospitalization period due to the treatment discontinuation steps.Akut bronşiolit iki yaş altı çocuklarda, viral ajanlar ile oluşan alt solunum yolu enfeksiyonudur. Tedavisinde hidrasyon, oksijen, nebulize salbutamol, damariçi steroid gibi yaklaşımlar bulunmaktadır. Çalışmamızda akut bronşiolit ile yatırılan olgularda klinik ilişkili etmenlerin belirlenlenmesi, viral ajanların kliniğe etkisi ve tedavi yöntemlerinin etkinliklerinin karşılaştırılması amaçlanmıştır.Çalışmamıza Mart 2015–Mart 2019 tarihleri arasında orta/ağır akut bronşiolit tanısı ile yatarak tedavi gören iki yaş altı olgular alındı. Olguların demografik verileri, yatış zamanı, vücut sıcaklığı, doğuştan kalp hastalığı olup olmaması, atopi öyküsü, akut faz reaktanları, ortalama trombosit hacmi, solunum virus panel sonuçları kaydedildi. Uygulanan tedavi yöntemleri, hastanede yatış süreleri, yoğun bakım yatışları ve yüksek akışlı nazal kanül oksijen tedavisi (YANKOT) alıp almadığı kaydedildi.Çalışmaya 422 hasta alındı. Bir yaş altı olguların ve asiyanotik doğuştan kalp hastalığı olan olguların yatış süreleri anlamlı olarak uzun saptandı. Olguların 69’unda (%51,9) tek viral etken saptandı. Olguların 70’inde Rinovirüs, 37’sinde respiratuar sinsityal virüs saptandı. Sadece oksijen ya/ya da damariçi sıvı tedavisi alanların yatış süreleri, bu tedavilerin yanında nebulize salbutamol ya/ya da damariçi steroid alanlarda anlamlı düzeyde kısa olduğu, YANKOT ve yoğun bakım yatış için iki grup arasında anlamlı fark olmadığı görüldü.Çalışmamızda akut bronşiolit etkenleri arasında en sık Rinovirüs saptandı. Doğuştan kalp hastalığının yatış süresini uzattığı görüldü. Tedavi yaklaşımlarında ise Amerikan Pediatri Akademisi önerileri ile uyumlu olarak, hidrasyon ve oksijen tedavisinin olgular için yeterli tedavi yöntemi olduğu ve nebulize tedavi vermenin tedavi kesme basamakları nedeni ile yatışı süresini uzattığı görüldü.

Published
2020

38. A diagnostic dilemma in a child with macroscopic hematuria, nephrotic syndrome, and hypocomplementemia: Questions

Author

Soyaltin, Eren, Çamlar, Seçil Arslansoyu, Alaygut, Demet, Mutlubas, Fatma, Yavascan, Önder, Solakoglu, Seyhun, and Demir, Belde Kasap

Subjects
Kidney diseases -- Case studies -- Diagnosis, Pediatric research -- Case studies, Health
Abstract

Author(s): Eren Soyaltin [sup.1] , Seçil Arslansoyu Çamlar [sup.1] , Demet Alaygut [sup.1] , Fatma Mutlubas [sup.1] , Önder Yavascan [sup.1] , Seyhun Solakoglu [sup.2] , Belde Kasap Demir [sup.1] [...]

Published
2020
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39. COVID-19 in pediatric nephrology centers in Turkey

Author

Bakkaloglu, Sevcan A., Atikel, Yesim Ozdemir, Leventoglu, Emre, Hulya Nalcacioglu, Dursun, Ismail, Poyrazoglu, Hakan, Dursun, Hasan, Yildirim, Zeynep Yuruk, Yildiz, Nurdan, Aksoy, Gulsah Kaya, Akman, Sema, Tasdemir, Mehmet, Bilge, Ilmay, Celakil, Mehtap, Kilic, Beltinge Demircioglu, Selcuk, Senay Zirhli, Canpolat, Nur, Cakici, Evrim Kargin, Ozlu, Sare Gulfem, Tulpar, Sebahat, Yuksel, Selcuk, Atmis, Bahriye, Doven, Serra Surmeli, Taner, Sevgin, Ertan, Pelin, Kavaz, Asli, Bayram, Meral Torun, Kalyoncu, Mukaddes, Gulleroglu, Kaan, Kabasakal, Caner, Demir, Belde Kasap, Cicek, Rumeysa Yasemin, Donmez, Osman, Kara, Aslihan, Yavascan, Onder, Ozcelik, Gul, Yildirim, Deniz Gezgin, Guler, Muhammet Akif, Sonmez, Ferah, Topaloglu, Rezan, and Alpay, Harika

Subjects
kidney, pediatric nephrology, Turkey, COVID-19, General Medicine, Children
Abstract

Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey. Materials and methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11th March 2020 and 11th March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry. Results: Two hundred and three patients (89 girls and 114 boys) were diagnosed with COVID-19. One-third of these patients (36.9%) were between 10–15 years old. Half of the patients were on kidney replacement therapy: kidney transplant (KTx) recipients (n = 56, 27.5%), patients receiving chronic hemodialysis (n = 33, 16.3%) and those on peritoneal dialysis (PD) (n = 18, 8.9%). Fifty-four (26.6%) children were asymptomatic. Eighty-two (40.3%) patients were hospitalized and 23 (28%) needed intensive care unit admission. Fifty-five percent of the patients were not treated, while the remaining was given favipiravir (20.7%), steroid (16.3%), and hydroxychloroquine (11.3%). Acute kidney injury developed in 19.5% of hospitalized patients. Five (2.4%) had MIS-C. Eighty-three percent of the patients were discharged without any apparent sequelae, while 7 (3.4%) died. One hundred and eight health care staff were infected during the study period. Conclusion: COVID-19 was most commonly seen in patients who underwent KTx and received HD. The combined immunosuppressive therapy and frequent exposure to the hospital setting may increase these patients’ susceptibility. Staff infections before vaccination era were alarming, various precautions should be taken for infection control, particularly optimal vaccination coverage. © TÜBİTAK.

Published
2022
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40. A new recommendation for febrile urinary tract infection in children aged 2–24 months: Tepecik UTI Guideline-2.

Author

Cezayir, Begüm Koyun, Yavascan, Önder, Alaygut, Demet, Demir, Belde Kasap, Mutlubas, Fatma, Camlar, Secil Arslansoyu, Alparslan, Caner, Soyaltin, Eren, and Ozgur, Su

Subjects
URINARY tract infections, VESICO-ureteral reflux, URINARY organs, RADIATION exposure, RADIATION damage
Abstract

Aim Urinary tract infections (UTIs) represent a common febrile illness in infancy. The study compared two UTI guidelines in terms of number of imaging studies, presence of parenchymal damage and radiation exposure in patients with the first febrile UTI between 2 and 24 months of age. Method The results of Tepecik UTI Guideline-1 used until 2012 (Group 1, n  = 105) were retrospectively compared with Tepecik UTI Guideline-2 (Group 2) used after 2013. In Group 1, urinary tract ultrasonography (US), dimercaptosuccinic acid (DMSA) and voiding cystourethrography (VCUG) were made in all patients. In Group 2, if the US result was abnormal, patients were evaluated with VCUG and DMSA. If the US was normal, only DMSA was performed. If the DMSA was abnormal, the VCUG was undergone (n : 43, 40.9%). Results The abnormal VCUG detection rate was 69.2% in Group 1 and 30.8% in Group 2 (p  = 0.09). Sensitivity and specificity of US in the diagnosis of vesicoureteral reflux (VUR) was 15.9% and 96.7% in Group 1 and 61.5% and 70.5% in Group 2, respectively. Abnormal DMSA findings were observed among 33.3% (Groups 1) and 66.7% (Groups 2) subjects, respectively (p  > 0.05). The median radiation exposure (500 mrem) of patients in Group 1 was statistically significantly higher than those in Group 2 (200 mrem) (p  < 0.001). Conclusion The VCUG should not be the first examination to be considered in such patients. We think that Tepecik UTI Guideline-2 reduces unnecessary invasive procedure and radiation exposure and not missed VUR in the management of children with UTI at 2–24 months. Needs prospective follow-up studies before considering this recommendation. [ABSTRACT FROM AUTHOR]

Published
2023
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42. A rare endocrinological complication of chronic kidney disease

Author

Çamlar, Seçil Arslansoyu, primary, Filibeli, Berna, additional, Soyaltın, Eren, additional, Manyas, Hayrullah, additional, Çatlı, Gönül, additional, Alaygut, Demet, additional, Mutlubaş, Fatma, additional, Dündar, Bumin Nuri, additional, and Demir, Belde Kasap, additional

Published
2022
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43. Comparison of childhood hypertension guidelines

Author

Başaran, Cemaliye and Demir, Belde Kasap

Subjects
Hipertansiyon, Hypertension, Blood pressure, Guideline, Kılavuz, Child, Çocuk, Kan basıncı
Abstract

Hipertansiyon (HT) çocukluk çağlarında giderek artan sıklıkta görülmektedir. Bu hastaların daha iyi değerlendirilmesi için çeşitli kılavuzlar yayınlanmıştır. Bunlar içinde en sık kullanılanlar; ABD Ulusal Kalp, Akciğer ve Kan Enstitüsü (NHLBI)’nün Ulusal Yüksek Kan Basıncı Eğitim Programı (NHBPEP) tarafından güncellenerek hazırlanan ve 2004’te yayınlanan 4. Rapor (4. Rapor-2004), 2016 yılında Avrupa Hipertansiyon Derneği tarafından hazırlanan kılavuz (ESH-2016), ve en sonuncusu 2017’de Amerikan Pediatri Akademisi tarafından hazırlanan kılavuzdur (AAP-2017). Bu kılavuzlar benzer olsa da aralarında ciddi farklar bulunmaktadır. 4. Rapor-2004 ve ESH-2016 kılavuzları, daha önce Amerikalı çocuklarda saptanan, yaşa ve boya göre oluşturulan kan basıncı (KB) persentil tablolarını kullanır. Daha sonra obez çocukların ölçümleri çıkarılarak yeni tablolar oluşturulmuş ve AAP-2017’de bu tablolar kullanılmıştır. ESH-2016’da 16 yaş, AAP-2017’de ise 13 yaşından itibaren KB değerlendirmelerinin erişkin kılavuzlarına göre yapılması önerilir. Hipertansif hastanın değerlendirilmesi, Yaşam İçi Kan Basıncı İzlemi (YİKBİ) kriterleri, laboratuvar testlerinin zamanlaması ve tedavi kılavuzlara göre farklılık göstermektedir. Sonuç olarak; henüz tüm dünya çocuklarını kapsayan evrensel KB tabloları oluşturulamamış olduğundan, ofis KB ve YİKBİ’nin değerlendirilmesinde hangi kılavuza göre hareket edileceği noktasında yaş, etnik ve coğrafi koşulların göz önünde bulundurulması gerekmektedir. Güncel olarak yayınlanan kılavuzların takip edilmesi ile ileride gelişebilecek kardiyovasküler olayların azaltılması mümkün olabilecektir. Hypertension (HT) is seen with increasing frequency in childhood. Various guidelines have been published to better evaluate these patients. The most frequently used of these are; The 4th Report (The 4th Report-2004) updated and published by the National Heart Lung and Blood Institute (NHLBI) National High Blood Pressure Education Program (NHBPEP) Working Group in 2004, a guideline prepared by the European Society of Hypertension in 2016 (ESH-2016), the last one is the guideline prepared by the American Academy of Pediatrics in 2017 (AAP-2017). Although these guidelines have some similarities, there are serious differences between them. The 4 th Report-2004 and ESH-2016 guidelines use blood pressure (BP) percentile tables based on age and height previously determined in American children. Then, new tables were created by extracting the measurements of obese children and these tables were used in AAP-2017. From the age of 16 in ESH-2016 and 13 in AAP-2017, it is recommended that BP evaluations should be made according to adult guidelines. Evaluation of the hypertensive patient, Ambulatory Blood Pressure Monitoring (ABPM) criteria, the timing of laboratory tests and treatment differ according to guidelines. As a result; since universal BP tables covering all children around the world have not yet been created; age, ethnic and geographical conditions should be taken into account when evaluating which guidelines the office BP and ABPM should follow. By following the currently published guidelines, it will be possible to reduce future cardiovascular events.

Published
2021

48. An Alternative Urinary Tract Irrigation Method in Children with Fungal Urinary Tract Infections.

Author

Erfidan, Gökçen, Soyaltın, Eren, Dadashova, Lale, Şimşek, Özgür Özdemir, Başaran, Cemaliye, Çamlar, Seçil Arslansoyu, Mutlubaş, Fatma, Demir, Belde Kasap, and Alaygut, Demet

Subjects
URINARY tract infections in children, IRRIGATION (Medicine), HYDRONEPHROSIS in children, AMPHOTERICIN B, ANTIFUNGAL agents
Abstract

Copyright of Journal of Tepecik Education & Research Hospital / İzmir Tepecik Eğitim ve Araştırma Hastanesi Dergisi is the property of Logos Medical Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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