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374 results on '"DEMINICE, RAFAEL"'

7. Voluntary Exercise Attenuates Hyperhomocysteinemia, But Does not Protect Against Hyperhomocysteinemia-Induced Testicular and Epididymal Disturbances

Author

dos Santos, Dayane Priscila, Ribeiro, Diogo Farias, Frigoli, Giovanna Fachetti, Erthal, Rafaela Pires, da Silva Scarton, Suellen Ribeiro, de Lion Siervo, Glaucia Eloísa Munhoz, Seiva, Fábio Rodrigues Ferreira, Staurengo-Ferrari, Larissa, Verri, Jr, Waldiceu Aparecido, Deminice, Rafael, and Fernandes, Glaura Scantamburlo Alves

Published
2022
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12. Sarcopenia in people living with the Human Immunodeficiency Virus: a systematic review and meta-analysis

Author

Oliveira, Vitor H. F., Borsari, Ana L., Webel, Allison R., Erlandson, Kristine M., and Deminice, Rafael

Subjects
HIV (Viruses) -- Risk factors -- Analysis, Sarcopenia -- Risk factors -- Analysis, Food/cooking/nutrition, Health
Abstract

People living with HIV (PLHIV) experience greater loss of muscle mass and function than people without HIV. However, HIV is not routinely recognized as a sarcopenia risk factor outside of HIV literature. The purposes of this study were to establish the prevalence and predictors of sarcopenia among PLHIV, and to compare the prevalence of sarcopenia among PLHIV and people without HIV. A systematic literature search of the PubMed, Embase, Cinahl, and Scielo databases was performed following PRISMA and MOOSE guidelines. Identified articles were included if they evaluated sarcopenia among PLHIV using either the presence of low muscle mass only or low muscle mass in association with low muscle function. The pooled prevalence of sarcopenia among PLHIV and the odds ratio for sarcopenia in PLHIV compared with controls were calculated. From 13 studies and 2267 participants, the prevalence of sarcopenia among PLHIV was 24.1% (95% CI = 17.8-31.0%). PLHIV presented 6.1 greater odds (95% CI = 1.1-33.5) of sarcopenia compared with people without HIV, matched by age, sex, BMI, and ethnicity. Longer exposure to specific HIV drugs, tobacco and alcohol, lower education and employment rates, and greater HIV duration were associated with sarcopenia. In conclusion, PLHIV had a high prevalence of sarcopenia, related to both HIV and non-HIV risk factors. HIV should be considered a risk factor for sarcopenia in the general population. CRD42019131449., Author(s): Vitor H. F. Oliveira [sup.1], Ana L. Borsari [sup.1], Allison R. Webel [sup.2], Kristine M. Erlandson [sup.3], Rafael Deminice [sup.1] Author Affiliations: (1) Department of Physical Education, State University [...]

Published
2020
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17. Doxorubicin causes cachexia, sarcopenia, and frailty characteristics in mice.

Author

Cella, Paola Sanches, Matos, Ricardo Luís Nascimento de, Marinello, Poliana Camila, Costa, Júlio Cesar da, Moura, Felipe Arruda, Bracarense, Ana Paula Frederico Rodrigues Loureiro, Chimin, Patricia, and Deminice, Rafael

Subjects
CACHEXIA, SARCOPENIA, DOXORUBICIN, WEIGHT loss, MUSCLE mass, MUSCULAR atrophy
Abstract

While chemotherapy treatment can be lifesaving, it also has adverse effects that negatively impact the quality of life. To investigate the effects of doxorubicin chemotherapy on body weight loss, strength and muscle mass loss, and physical function impairments, all key markers of cachexia, sarcopenia, and frailty. Seventeen C57/BL/6 mice were allocated into groups. 1) Control (n = 7): mice were exposed to intraperitoneal (i.p.) injections of saline solution. 2) Dox (n = 10): mice were exposed to doxorubicin chemotherapy cycles (total dose of 18 mg/kg divided over 15 days). The body weight loss and decreased food intake were monitored to assess cachexia. To assess sarcopenia, we measured muscle strength loss using a traction method and evaluated muscle atrophy through histology of the gastrocnemius muscle. To evaluate physical function impairments and assess frailty, we employed the open field test to measure exploratory capacity. Doxorubicin administration led to the development of cachexia, as evidenced by a significant body weight loss (13%) and a substantial decrease in food intake (34%) over a 15-day period. Furthermore, 90% of the mice treated with doxorubicin exhibited sarcopenia, characterized by a 20% reduction in traction strength (p<0,05), a 10% decrease in muscle mass, and a 33% reduction in locomotor activity. Importantly, all mice subjected to doxorubicin treatment were considered frail based on the evaluation of their overall condition and functional impairments. The proposed model holds significant characteristics of human chemotherapy treatment and can be useful to understand the intricate relationship between chemotherapy, cachexia, sarcopenia, and frailty. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Health and sociodemographic factors associated with low muscle strength, muscle mass, and physical performance among people living with HIV.

Author

Oliveira, Vitor H. F., Webel, Allison R., Borsari, Ana Lucia, Cárdenas, José David G., and Deminice, Rafael

Subjects
GRIP strength, HYPERTENSION, SKELETAL muscle, CONFIDENCE intervals, MULTIPLE regression analysis, MUSCLE strength, BODY movement, BIOELECTRIC impedance, EMPLOYMENT, RESEARCH funding, SOCIODEMOGRAPHIC factors, BODY mass index, ODDS ratio, RHEUMATISM, PSYCHOLOGY of HIV-positive persons, COMORBIDITY, LYMPHOCYTE count, EDUCATIONAL attainment
Abstract

This study examined the factors associated with low muscle strength, muscle mass, and physical performance in 331 people living with HIV. Participants completed handgrip as a strength measure, appendicular skeletal muscle mass using bioimpedance analysis, and chair rise was a physical performance measure. Multivariate logistic regression was used to analyze the association between low values on these measures with sociodemographic, HIV-related factors, and comorbidities. Higher body mass index (BMI) (OR = 0.91; CI = 0.86-0.97) and higher CD4/CD8 ratio (OR = 0.38; 95% CI = 0.18-0.82) were associated with decreased likelihood of low handgrip strength. Being non-employed (OR = 2.08; 95% CI = 1.07-4.06), having hypertension (OR = 2.27; 95% CI = 1.13-4.54) and rheumatism (OR = 5.46; 95% CI = 1.68-17.74) increased the chance of low handgrip strength. Higher BMI (OR = 0.43; 95% CI = 0.34-0.56), CD4/CD8 ratio (OR = 0.29; 95% CI = 0.09-0.93), and bioimpedance phase angle (OR = 0.22; 95% CI = 0.12-0.40) were associated with decreased likelihood of low muscle mass. Lastly, having less than eight years of education (OR = 1.87; 95% CI = 1.02-3.41) and being non-employed (OR = 8.18; 95% CI = 3.09-21.61) increased the chance of low chair stand performance. In addition, higher CD4 + lymphocytes count (OR = 0.99; 95% CI = 0.99-0.99) was associated with a decreased likelihood of low chair stand performance. In conclusion, specific and non-specific HIV-related factors are associated with low handgrip strength, low muscle mass, and/or low chair stand performance. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Corrigendum to “Creatine supplementation protects against diet-induced non-alcoholic fatty liver but exacerbates alcoholic fatty liver” [Life Sci. 310 (2022) 121064 (1 December 2022)]

Author

Marinello, Poliana C., primary, Cella, Paola S., additional, Testa, Mayra T.J., additional, Guirro, Phillipe B., additional, da Silva Brito, Walison Augusto, additional, Padilha, Camila S., additional, Cecchini, Alessandra L., additional, da Silva, Robin P., additional, Duarte, José Alberto R., additional, and Deminice, Rafael, additional

Published
2023
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35. Effect of Resistance Exercise Order on Cardiovascular Disease Risk Factors in Older Women: A Randomized Controlled Trial

Author

Tomeleri, Crisieli M., primary, Cunha, Paolo M., additional, Dib, Márcia M., additional, Schiavoni, Durcelina, additional, Kassiano, Witalo, additional, Costa, Bruna, additional, Teixeira, Denilson C., additional, Deminice, Rafael, additional, Rodrigues, Ricardo José, additional, Venturini, Danielle, additional, Barbosa, Décio S., additional, Cavaglieri, Cláudia R., additional, Sardinha, Luís B., additional, and Cyrino, Edilson S., additional

Published
2023
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42. Resistance Training Attenuates Activation of STAT3 and Muscle Atrophy in Tumor-Bearing Mice

Author

Testa, Mayra Tardelli de Jesus, primary, Cella, Paola Sanches, additional, Marinello, Poliana Camila, additional, Frajacomo, Fernando Tadeu Trevisan, additional, Padilha, Camila de Souza, additional, Perandini, Patricia Chimin, additional, Moura, Felipe Arruda, additional, Duarte, José Alberto, additional, Cecchini, Rubens, additional, Guarnier, Flavia Alessandra, additional, and Deminice, Rafael, additional

Published
2022
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45. Effects of ovariectomy and resistance training on oxidative stress markers in the rat liver

Author

Rodrigues, Maria Fernanda Cury, Stotzer, Uliana Sbeguen, Domingos, Mateus Moraes, Deminice, Rafael, Shiguemoto, Gilberto Eiji, Tomaz, Luciane Magri, de Sousa, Nuno Manuel Frade, Ferreira, Fabiano Candido, Leite, Richard Diego, Selistre-de-Araújo, Heloisa Sobreiro, Jordão-Júnior, Alceu Afonso, Baldissera, Vilmar, and de Andrade Perez, Sérgio Eduardo

Published
2013
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46. EXERCÍCIO FÍSICO PARA O TRATAMENTO DO CÂNCER: EVIDÊNCIAS CIENTÍFICAS E O CONTEXTO BRASILEIRO

Author

Deminice, Rafael

Subjects
Oncology, Oncologia, prescrição de exercício, adverse effects, exercise prescription, survival, efeitos adversos, sobrevivência
Abstract

It is now well-known that physical activity and exercise are both able to prevent the appearance of different types of cancer, increase survival, improve quality of life and attenuate the adverse effects caused by cancer and its treatment. Therefore, the current recommendation is that every cancer survivor must be encouraged to stay active, begin or keep exercising after the cancer diagnosis, contrary to the recommendation of 20 years ago to “rest and avoid physical efforts”. In fact, physical exercise is now recognized as a reliable, inexpensive, adverse effect-free, safe and relatively simple tool to be incorporated into the context of cancer treatment. However, Brazil has not contributed and is not part of the agenda to make exercise as a standard in cancer care. This literature review aims to present the scientific evidence of the use of physical exercise in the different stages of cancer treatment and the most recent contributions to the development of exercise prescription for people with cancer. In addition, I will discuss the main challenges and future perspectives for the area of exercise oncology, considering the Brazilian context. RESUMO Sabe-se hoje que a atividade e o exercício físico são capazes de prevenir o aparecimento de diferentes tipos de câncer, aumentar a sobrevida e a qualidade de vida, além de amenizar os efeitos adversos causados pelo câncer e seu tratamento. Assim, a recomendação atual é que todo indivíduo com câncer deve ser encorajado a manter-se ativo, iniciar a prática de exercícios ou continuar se exercitando após o diagnóstico da doença, ao contrário da recomendação de 20 anos atrás de “descansar e evitar esforços físicos”. De fato, o exercício físico é considerado hoje, uma ferramenta completa, barata, isenta de efeitos colaterais, segura e relativamente simples de ser incorporada no contexto do tratamento do câncer. Entretanto, o Brasil não tem contribuído e não está inserido na agenda para transformar o exercício físico como parte do tratamento oncológico. Esta revisão de literatura tem o objetivo de apresentar as principais evidências científicas sobre uso do exercício físico nas diversas fases do tratamento do câncer e as mais recentes contribuições para o desenvolvimento da prescrição do exercício físico em pacientes oncológicos, além de discutir os principais desafios e perspectivas futuras para a área de exercício físico em oncologia, considerando o contexto brasileiro.

Published
2022

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