273 results on '"DE SIMONE, ANGELA"'
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2. From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects
3. Hit Identification and Functional Validation of Novel Dual Inhibitors of HDAC8 and Tubulin Identified by Combining Docking and Molecular Dynamics Simulations.
4. Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer
5. Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer’s disease
6. First in Class Dual Non-ATP-Competitive Glycogen Synthase Kinase 3β/Histone Deacetylase Inhibitors as a Potential Therapeutic to Treat Alzheimer’s Disease
7. Phenolic and Antioxidant Characterization of Fruit By-Products for Their Nutraceuticals and Dietary Supplements Valorization under a Circular Bio-Economy Approach
8. A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors
9. Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease
10. Design of Experiments and Optimization of Monacolin K Green Extraction from Red Yeast Rice by Ultra-High-Performance Liquid Chromatography.
11. Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties.
12. Integrating a quinone substructure into histone deacetylase inhibitors to cope with Alzheimer's disease and cancer.
13. Hydroxy-substituted trans-cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease
14. Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018
15. Reprint of: Liquid chromatographic enzymatic studies with on-line Beta-secretase immobilized enzyme reactor and 4-(4-dimethylaminophenylazo) benzoic acid/5-[(2-aminoethyl) amino] naphthalene-1-sulfonic acid peptide as fluorogenic substrate
16. Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease
17. Liquid chromatographic enzymatic studies with on-line Beta-secretase immobilized enzyme reactor and 4-(4-dimethylaminophenylazo) benzoic acid/5-[(2-aminoethyl) amino] naphthalene-1-sulfonic acid peptide as fluorogenic substrate
18. Integrating a quinone substructure into histone deacetylase inhibitors to cope with Alzheimer's disease and cancerElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d4md00175c
19. Integrated analytical approaches for the characterization of Spirulina and Chlorella microalgae
20. Aβ1-42 peptide toxicity on neuronal cells: A lipidomic study
21. Fentanyl pharmacokinetics in blood of cancer patients by Gas Chromatography – Mass Spectrometry
22. Application of an ESI-QTOF method for the detailed characterization of GSK-3β inhibitors
23. Other Techniques of Utility for Olive Oil Analysis
24. A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation
25. Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease
26. Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease
27. Natural products as novel scaffolds for the design of glycogen synthase kinase 3β inhibitors
28. Direct determination of GSK-3β activity and inhibition by UHPLC-UV–vis diode arrays detector (DAD)
29. Surface plasmon resonance, fluorescence, and circular dichroism studies for the characterization of the binding of BACE-1 inhibitors
30. Beta-secretase as a target for Alzheimer’s disease drug discovery: an overview of in vitro methods for characterization of inhibitors
31. Circular dichroism in drug discovery and development: an abridged review
32. (±)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer’s Disease
33. Human recombinant beta-secretase immobilized enzyme reactor for fast hits’ selection and characterization from a virtual screening library
34. Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice
35. Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer’s Disease Multitarget Drug Discovery?
36. Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6
37. Structural characterization of p53 isoforms due to the polymorphism at codon 72 by mass spectrometry and circular dichroism
38. Derivatives of the beta-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer's Disease
39. Deriváty beta-Crinane Amaryllidaceae Alkaloid Haemanthamine jako vícecílové cílené ligandy pro Alzheimerovu chorobu
40. Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget antiAlzheimer compounds
41. Advanced analytical methodologies in Alzheimer’s disease drug discovery
42. Pyridinylimidazoles as GSK3β Inhibitors: The Impact of Tautomerism on Compound Activity via Water Networks
43. Correction to “Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer’s Disease”
44. Investigating in Vitro Amyloid Peptide 1–42 Aggregation: Impact of Higher Molecular Weight Stable Adducts
45. Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery?
46. Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer’s Disease
47. Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer’s Disease
48. Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice.
49. Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer's Disease Multitarget Drug Discovery?
50. Immobilized Enzyme Reactors: an Overview of Applications in Drug Discovery from 2008 to 2018
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