536 results on '"DE PONTI, P"'
Search Results
2. Can you hear the Planck mass?
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De Luca, G. Bruno, De Ponti, Nicolò, Mondino, Andrea, and Tomasiello, Alessandro
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High Energy Physics - Theory ,General Relativity and Quantum Cosmology ,Mathematical Physics ,Mathematics - Differential Geometry ,Mathematics - Metric Geometry - Abstract
For the Laplacian of an $n$-Riemannian manifold $X$, the Weyl law states that the $k$-th eigenvalue is asymptotically proportional to $(k/V)^{2/n}$, where $V$ is the volume of $X$. We show that this result can be derived via physical considerations by demanding that the gravitational potential for a compactification on $X$ behaves in the expected $(4+n)$-dimensional way at short distances. In simple product compactifications, when particle motion on $X$ is ergodic, for large $k$ the eigenfunctions oscillate around a constant, and the argument is relatively straightforward. The Weyl law thus allows to reconstruct the four-dimensional Planck mass from the asymptotics of the masses of the spin 2 Kaluza--Klein modes. For warped compactifications, a puzzle appears: the Weyl law still depends on the ordinary volume $V$, while the Planck mass famously depends on a weighted volume obtained as an integral of the warping function. We resolve this tension by arguing that in the ergodic case the eigenfunctions oscillate now around a power of the warping function rather than around a constant, a property that we call weighted quantum ergodicity. This has implications for the problem of gravity localization, which we discuss. We show that for spaces with D$p$-brane singularities the spectrum is discrete only for $p =6,7,8$, and for these cases we rigorously prove the Weyl law by applying modern techniques from RCD theory., Comment: 35 pages, 1 figure
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- 2024
3. Unveiling the Burden of Drug-Induced Impulsivity: A Network Analysis of the FDA Adverse Event Reporting System
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Fusaroli, Michele, Polizzi, Stefano, Menestrina, Luca, Giunchi, Valentina, Pellegrini, Luca, Raschi, Emanuel, Weintraub, Daniel, Recanatini, Maurizio, Castellani, Gastone, De Ponti, Fabrizio, and Poluzzi, Elisabetta
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- 2024
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4. Adopting STOPP/START Criteria Version 3 in Clinical Practice: A Q&A Guide for Healthcare Professionals
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Lunghi, Carlotta, Domenicali, Marco, Vertullo, Stefano, Raschi, Emanuel, De Ponti, Fabrizio, Onder, Graziano, and Poluzzi, Elisabetta
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- 2024
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5. Properties of Lipschitz smoothing heat semigroups
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De Ponti, Nicolò and Stefani, Giorgio
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Mathematics - Functional Analysis ,Primary 53C23. Secondary 31E05, 58J35 - Abstract
We prove several functional and geometric inequalities only assuming the linearity and a quantitative $\mathrm{L}^\infty$-to-Lipschitz smoothing of the heat semigroup in metric-measure spaces. Our results comprise a Buser inequality, a lower bound on the size of the nodal set of a Laplacian eigenfunction, and different estimates involving the Wasserstein distance. The approach works in large variety settings, including Riemannian manifolds with a variable Kato-type lower bound on the Ricci curvature tensor, $\mathsf{RCD}(K,\infty)$ spaces, and some sub-Riemannian structures, such as Carnot groups, the Grushin plane and the $\mathbb{SU}(2)$ group., Comment: 23 pages
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- 2024
6. Unique continuation at infinity: Carleman estimates on general warped cylinders
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De Ponti, Nicolò, Pigola, Stefano, and Veronelli, Giona
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Mathematics - Analysis of PDEs ,Mathematics - Differential Geometry - Abstract
We obtain a vanishing result for solutions of the inequality $|\Delta u|\le q_1|u|+q_2|\nabla u|$ that decay to zero along a very general warped cylindrical end of a Riemannian manifold. The appropriate decay condition at infinity on $u$ is related to the behavior of the potential functions $q_1$ and $q_2$ and to the asymptotic geometry of the end. The main ingredient is a new Carleman estimate of independent interest. Geometric applications to conformal deformations and to minimal graphs are presented., Comment: Minor corrections following referee's suggestions. Final version, to appear on IMRN
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- 2024
7. Basal FSH values are positively associated with aneuploidy incidence in pre-advanced maternal age (AMA) but not in AMA patients
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Jacobs, Catherine K., Nicolielo, Mariana, Alegretti, José Roberto, Canto, Mariabeatrice Dal, Renzini, Mario Mignini, De Ponti, Elena, Chehin, Mauricio Barbour, Motta, Eduardo L. A., Lorenzon, Aline R., and Buratini, Jose
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- 2024
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8. Peer Review in Pharmacovigilance: Lens on Disproportionality Analysis
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Raschi, Emanuel, Salvo, Francesco, Bate, Andrew, De Ponti, Fabrizio, Poluzzi, Elisabetta, Tuccori, Marco, van Puijenbroek, Eugène, Joshi, Nitin, and Khouri, Charles
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- 2024
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9. Enhancing therapeutic reasoning: key insights and recommendations for education in prescribing
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Hartjes, Mariëlle G., Richir, Milan C., Cazaubon, Yoann, Donker, Erik M., van Leeuwen, Ellen, Likic, Robert, Pers, Yves-Marie, Piët, Joost D., De Ponti, Fabrizio, Raasch, Walter, van Rosse, Floor, Rychlícková, Jitka, Sanz, Emilio J., Schwaninger, Markus, Wallerstedt, Susanna M., de Vries, Theo P. G. M., van Agtmael, Michiel A., and Tichelaar, Jelle
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- 2024
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10. Healthcare-associated infections and antimicrobial use in acute care hospitals: a point prevalence survey in Lombardy, Italy, in 2022
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Antonelli, Antonio, Ales, Maria Elena, Chiecca, Greta, Dalla Valle, Zeno, De Ponti, Emanuele, Cereda, Danilo, Crottogini, Lucia, Renzi, Cristina, Signorelli, Carlo, and Moro, Matteo
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- 2024
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11. Enhancing therapeutic reasoning: key insights and recommendations for education in prescribing
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Mariëlle G. Hartjes, Milan C. Richir, Yoann Cazaubon, Erik M. Donker, Ellen van Leeuwen, Robert Likic, Yves-Marie Pers, Joost D. Piët, Fabrizio De Ponti, Walter Raasch, Floor van Rosse, Jitka Rychlícková, Emilio J. Sanz, Markus Schwaninger, Susanna M. Wallerstedt, Theo P. G. M. de Vries, Michiel A. van Agtmael, Jelle Tichelaar, and On behalf of the EACPT Education Working group
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Therapeutic reasoning ,Medical decision making ,Clinical pharmacology and therapeutics ,Medical education ,Management reasoning ,Clinical competency ,Special aspects of education ,LC8-6691 ,Medicine - Abstract
Abstract Background Despite efforts to improve undergraduate clinical pharmacology & therapeutics (CPT) education, prescribing errors are still made regularly. To improve CPT education and daily prescribing, it is crucial to understand how therapeutic reasoning works. Therefore, the aim of this study was to gain insight into the therapeutic reasoning process. Methods A narrative literature review has been performed for literature on cognitive psychology and diagnostic and therapeutic reasoning. Results Based on these insights, The European Model of Therapeutic Reasoning has been developed, building upon earlier models and insights from cognitive psychology. In this model, it can be assumed that when a diagnosis is made, a primary, automatic response as to what to prescribe arises based on pattern recognition via therapy scripts (type 1 thinking). At some point, this response may be evaluated by the reflective mind (using metacognition). If it is found to be incorrect or incomplete, an alternative response must be formulated through a slower, more analytical and deliberative process, known as type 2 thinking. Metacognition monitors the reasoning process and helps a person to form new therapy scripts after they have chosen an effective therapy. Experienced physicians have more and richer therapy scripts, mostly based on experience and enabling conditions, instead of textbook knowledge, and therefore their type 1 response is more often correct. Conclusion Because of the important role of metacognition in therapeutic reasoning, more attention should be paid to metacognition in CPT education. Both trainees and teachers should be aware of the possibility to monitor and influence these cognitive processes. Further research is required to investigate the applicability of these insights and the adaptability of educational approaches to therapeutic reasoning.
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- 2024
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12. Disability and Participation in Colorectal Cancer Screening: A Systematic Review and Meta-Analysis
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Giovanni Emanuele Ricciardi, Rita Cuciniello, Emanuele De Ponti, Carlo Lunetti, Flavia Pennisi, Carlo Signorelli, and Cristina Renzi
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disability ,colorectal cancer ,screening ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: The aim of this study is to assess the impact of disability on participation in CRC screening and to determine the overall effect size. Methods: We conducted a systematic review and meta-analysis to compare CRC screening participation in individuals with and without disabilities. The search encompassed five databases (PubMed, EMBASE, Scopus, Google Scholar, medRxiv). Pooled estimates were calculated for each type of CRC screening and disability categories to synthesize the findings. The participation in CRC screening was derived using a random effects model. Results: A total of 20 articles were included, most of them from the USA. Based on pooled estimates, individuals with disabilities have lower odds of undergoing CRC screening versus those without disabilities (OR = 0.80, 95%CI 0.73–0.87). Analysis by screening type indicated that individuals with a disability have lower odds of a fecal occult blood test or a fecal immunochemical test (OR: 0.72, 95%CI 0.65–0.81), with no significant difference for a colonoscopy. Individuals with intellectual disabilities had significantly lower rates of CRC screening participation (OR = 0.65, 95%CI 0.53–0.79), especially for FOBT/FIT (OR = 0.58, 95%CI 0.49–0.69). Conclusions: Disparities exist for CRC screening participation in people with disabilities. Further research and coordinated efforts are essential to develop interventions for improving early cancer diagnosis for this non-negligible patient group.
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- 2024
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13. Localized topological states beyond Fano resonances via counter-propagating wave mode conversion in piezoelectric microelectromechanical devices
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Jacopo M. De Ponti, Xuanyi Zhao, Luca Iorio, Tommaso Maggioli, Marco Colangelo, Benyamin Davaji, Raffaele Ardito, Richard V. Craster, and Cristian Cassella
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Science - Abstract
Abstract A variety of scientific fields like proteomics and spintronics have created a new demand for on-chip devices capable of sensing parameters localized within a few tens of micrometers. Nano and microelectromechanical systems (NEMS/MEMS) are extensively employed for monitoring parameters that exert uniform forces over hundreds of micrometers or more, such as acceleration, pressure, and magnetic fields. However, they can show significantly degraded sensing performance when targeting more localized parameters, like the mass of a single cell. To address this challenge, we present a MEMS device that leverages the destructive interference of two topological radiofrequency (RF) counter-propagating wave modes along a piezoelectric Aluminum Scandium Nitride (AlScN) Su-Schrieffer-Heeger (SSH) interface. The reported MEMS device opens up opportunities for further purposes, including achieving more stable frequency sources for communication and timing applications.
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- 2024
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14. Pleijel nodal domain theorem in non-smooth setting
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De Ponti, Nicolò, Farinelli, Sara, and Violo, Ivan Yuri
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Mathematics - Spectral Theory ,Mathematics - Analysis of PDEs ,Mathematics - Metric Geometry - Abstract
We prove the Pleijel theorem in non-collapsed RCD spaces, providing an asymptotic upper bound on the number of nodal domains of Laplacian eigenfunctions. As a consequence, we obtain that the Courant nodal domain theorem holds except at most for a finite number of eigenvalues. More in general, we show that the same result is valid for Neumann (resp. Dirichlet) eigenfunctions on uniform domains (resp. bounded open sets). This is new even in the Euclidean space, where the Pleijel theorem in the Neumann case was open under low boundary-regularity., Comment: Added the Dirichlet case and fixed minor typos
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- 2023
15. Emerging Toxicities of Antibody-Drug Conjugates for Breast Cancer: Clinical Prioritization of Adverse Events from the FDA Adverse Event Reporting System
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Cecco, Sara, Puligheddu, Stefano, Fusaroli, Michele, Gerratana, Lorenzo, Yan, Miao, Zamagni, Claudio, De Ponti, Fabrizio, and Raschi, Emanuel
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- 2024
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16. Phononic graded meta-MEMS for elastic wave amplification and filtering
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Maspero, Federico, De Ponti, Jacopo Maria, Iorio, Luca, Esposito, Annachiara, Bertacco, Riccardo, di Matteo, Andrea, Corigliano, Alberto, and Ardito, Raffaele
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Physics - Applied Physics - Abstract
Inspired by recent graded metamaterials designs, we create phononic arrays of micro-resonators for frequency signal amplification and wave filtering. Leveraging suspended waveguides on a thick silicon substrate, we hybridize surface Rayleigh and Lamb flexural waves to effectively achieve phononic signal control along predefined channels. The guided waves are then spatially controlled using a suitable grading of the micro-resonators, which provide high signal-to-noise ratio and simultaneously create phononic delay-lines. The proposed device can be used for sensing, wave filtering or energy harvesting.
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- 2023
17. Harmonic functions and gravity localization
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De Luca, G. Bruno, De Ponti, Nicolò, Mondino, Andrea, and Tomasiello, Alessandro
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High Energy Physics - Theory ,General Relativity and Quantum Cosmology ,Mathematical Physics ,Mathematics - Differential Geometry ,Mathematics - Metric Geometry - Abstract
In models with extra dimensions, matter particles can be easily localized to a 'brane world', but gravitational attraction tends to spread out in the extra dimensions unless they are small. Strong warping gradients can help localize gravity closer to the brane. In this note we give a mathematically rigorous proof that the internal wave-function of the massless graviton is constant as an eigenfunction of the weighted Laplacian, and hence is a power of the warping as a bound state in an analogue Schr\"odinger potential. This holds even in presence of singularities induced by thin branes. We also reassess the status of AdS vacuum solutions where the graviton is massive. We prove a bound on scale separation for such models, as an application of our recent results on KK masses. We also use them to estimate the scale at which gravity is localized, without having to compute the spectrum explicitly. For example, we point out that localization can be obtained at least up to the cosmological scale in string/M-theory solutions with infinite-volume Riemann surfaces; and in a known class of N = 4 models, when the number of NS5- and D5-branes is roughly equal., Comment: 43 pages, 2 figures
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- 2023
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18. Implementing Clinical Case Discussions to Enhance Clinical Reasoning Skills: A Pilot Study in an Italian Medical School
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Valentina Colonnello, Aurelia Zodl, Davide Agnoletti, Kilian Lischeid, Lena Cimbalnik, Marc Weidenbusch, Martin R. Fischer, Fabrizio De Ponti, and Christian Rausch
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clinical reasoning ,clinical case discussions ,case-based learning ,medical education ,peer teaching ,curriculum development ,Special aspects of education ,LC8-6691 ,Medicine - Abstract
Background: Clinical reasoning (CR) is fundamental in medical education. However, the Italian curriculum has not incorporated a structured CR format yet. Therefore, we introduced the Clinical Case Discussions (CCD), to medical students attending the University of Bologna as a tool for developing CR abilities. CCDs are a case-based peer-teaching format, simulating the diagnostic process using published patient cases. Methods: Students of all clinical years of the University of Bologna Medical School were invited to voluntarily participate in a two-day CCD training program. They completed pre- and post-training questionnaires assessing their expectations before and impressions after the training and comparing learning outcomes to their usual classes. Results: Twenty-one students participated in this pilot program. Before the training, more than half of the participants expressed either interest or a strong interest in all proposed learning objectives. Afterward, 84.6% of the students stated that the training much exceeded (63.5%) or exceeded (23.1%) their expectations considering its utility for their future medical activities. A total of 92.3% strongly agreed (84.6%) or agreed (7.7%) to have improved their CR. Conclusions: Although this pilot program had some intrinsic limitations, the students’ positive feedback on this CCD format (combining the benefits of case-based learning and peer teaching) encourages further research on its potential role in the Italian curriculum.
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- 2024
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19. Can you hear the Planck mass?
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G. Bruno De Luca, Nicolò De Ponti, Andrea Mondino, and Alessandro Tomasiello
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Classical Theories of Gravity ,Extra Dimensions ,Flux Compactifications ,Superstring Vacua ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract For the Laplacian of an n-Riemannian manifold X, the Weyl law states that the k-th eigenvalue is asymptotically proportional to (k/V)2/n , where V is the volume of X. We show that this result can be derived via physical considerations by demanding that the gravitational potential for a compactification on X behaves in the expected (4+n)-dimensional way at short distances. In simple product compactifications, when particle motion on X is ergodic, for large k the eigenfunctions oscillate around a constant, and the argument is relatively straightforward. The Weyl law thus allows to reconstruct the four-dimensional Planck mass from the asymptotics of the masses of the spin 2 Kaluza-Klein modes. For warped compactifications, a puzzle appears: the Weyl law still depends on the ordinary volume V, while the Planck mass famously depends on a weighted volume obtained as an integral of the warping function. We resolve this tension by arguing that in the ergodic case the eigenfunctions oscillate now around a power of the warping function rather than around a constant, a property that we call weighted quantum ergodicity. This has implications for the problem of gravity localization, which we discuss. We show that for spaces with Dp-brane singularities the spectrum is discrete only for p = 6, 7, 8, and for these cases we rigorously prove the Weyl law by applying modern techniques from RCD theory.
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- 2024
- Full Text
- View/download PDF
20. Bandgap widening and resonating mass reduction through wave locking
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Iorio, Luca, De Ponti, Jacopo M., Corigliano, Alberto, and Ardito, Raffaele
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Physics - Classical Physics - Abstract
Elastic metamaterials made from locally resonant arrays have been developed as effective ways to create band gaps for elastic or acoustic travelling waves. They work by implementing stationary states in the structure that localise and partially reflect waves. A different, simpler, way of obtaining band gaps is using phononic crystals, where the generated band gaps come from the periodic reflection and phase cancellation of travelling waves. In this work a different metamaterial structure that generates band gaps by means of coupling two contra-propagating modes is reported. This metamaterial, as it will be shown numerically and experimentally, generates larger band gaps with lower added mass, providing benefits for lighter structures.
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- 2023
21. Understanding the complex macrophage landscape in MASLDKeypoints
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Federico F. De Ponti, Zhuangzhuang Liu, and Charlotte L. Scott
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Macrophages ,MASLD ,Kupffer cells ,LAMs ,TREM2 ,Osteopontin ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Summary: Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a spectrum of disease states ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), which can eventually lead to the development of cirrhosis and hepatocellular carcinoma. Macrophages have long been implicated in driving the progression from steatosis to end-stage disease, yet we still know relatively little about the precise involvement of these cells in MASLD progression and/or regression. Rather, there are a considerable number of conflicting reports regarding the precise roles of these cells. This confusion stems from the fact that, until recently, macrophages in the liver were considered a homogenous population. However, thanks to recent technological advances including multi-parameter flow cytometry, single-cell RNA sequencing and spatial proteogenomics, we now know that this is not the case. Rather hepatic macrophages, even in the healthy liver, are heterogenous, existing in multiple subsets with distinct transcriptional profiles and hence likely functions. This heterogeneity is even more prominent in MASLD, where the macrophage pool consists of multiple different subsets of resident and recruited cells. To probe the unique functions of these cells and determine if targeting macrophages may be a viable therapeutic strategy in MASLD, we first need to unravel this complexity and decipher which populations and/or activation states are present and what functions each of these may play in driving MASLD progression. In this review, we summarise recent advances in the field, highlighting what is currently known about the hepatic macrophage landscape in MASLD and the questions that remain to be tackled.
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- 2024
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22. Gravity from thermodynamics: optimal transport and negative effective dimensions
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De Luca, G. Bruno, De Ponti, Nicolò, Mondino, Andrea, and Tomasiello, Alessandro
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High Energy Physics - Theory ,General Relativity and Quantum Cosmology ,Mathematical Physics ,Mathematics - Differential Geometry ,Mathematics - Metric Geometry - Abstract
We prove an equivalence between the classical equations of motion governing vacuum gravity compactifications (and more general warped-product spacetimes) and a concavity property of entropy under time evolution. This is obtained by linking the theory of optimal transport to the Raychaudhuri equation in the internal space, where the warp factor introduces effective notions of curvature and (negative) internal dimension. When the Reduced Energy Condition is satisfied, concavity can be characterized in terms of the cosmological constant $\Lambda$; as a consequence, the masses of the spin-two Kaluza-Klein fields obey bounds in terms of $\Lambda$ alone. We show that some Cheeger bounds on the KK spectrum hold even without assuming synthetic Ricci lower bounds, in the large class of infinitesimally Hilbertian metric measure spaces, which includes D-brane and O-plane singularities. As an application, we show how some approximate string theory solutions in the literature achieve scale separation, and we construct a new explicit parametrically scale-separated AdS solution of M-theory supported by Casimir energy., Comment: 57 pages + 4 appendices, 4 figures. v2: expanded introduction and comments on the Casimir vacuum. v3: clarification on the agreement of the Casimir vacuum with conjectured bounds
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- 2022
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23. Optimised graded metamaterials for mechanical energy confinement and amplification via reinforcement learning
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Rosafalco, Luca, De Ponti, Jacopo Maria, Iorio, Luca, Ardito, Raffaele, and Corigliano, Alberto
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Physics - Applied Physics - Abstract
A reinforcement learning approach to design optimised graded metamaterials for mechanical energy confinement and amplification is described. Through the proximal policy optimisation algorithm, the reinforcement agent is trained to optimally set the lengths and the spacing of an array of resonators. The design optimisation problem is formalised in a Markov decision problem by splitting the optimisation procedure into a discrete number of decisions. Being the physics of graded metamaterials governed by the spatial distribution of local resonances, the space of possible configurations is constrained by using a continuous function for the resonators arrangement. A preliminary analytical investigation has been performed to characterise the dispersive properties of the analysed system by treating it as a locally resonant system. The outcomes of the optimisation procedure confirms the results of previous investigations, highlighting both the validity of the proposed approach and the robustness of the systems of graded resonators when employed for mechanical energy confinement and amplification. The role of the resonator spacing is shown to be secondary with respect to the resonator lengths or, in other words, with respect to the oscillation frequencies of the resonators. However, it is also demonstrated that reducing the number of resonators can be advantageous. The outcomes related to the joint optimisation of the resonator lengths and spacing, thanks also to the adaptive control of the analysis duration, overcome significantly the performance of previously known systems by working almost uniquely on enlarging the time in which the harvester oscillations take place without amplifying these oscillations. The proposed procedure is suitable to be applied to a wide range of design optimisation problems in which the effect of the design choices can be assessed through numerical simulations., Comment: 41 pages
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- 2022
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24. Roton-like dispersion via polarisation change for elastic wave energy control in graded delay-lines
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Iorio, Luca, De Ponti, Jacopo Maria, Maspero, Federico, and Ardito, Raffaele
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Physics - Classical Physics - Abstract
While roton dispersion relations had been restricted to correlated quantum systems at low temperature, recent works show the possibility of obtaining this unusual dispersion in acoustic and elastic metamaterials. Such phenomenon has been demonstrated in periodic structures by means of beyond-nearest-neighbor interactions, following the formulation firstly developed by Brillouin in the $'50s$. In this paper, we demonstrate both numerically and experimentally that beyond-nearest-neighbor connections are not a necessary condition to obtain this unusual dispersion relation in elasticity. Leveraging the intrinsic complexity of elastic systems supporting different types of waves, we demonstrate that mode locking can be applied to obtain roton dispersion, without the need of elastic or magnetic interactions between non nearest neighbors. Moreover, the combination of roton dispersion and rainbow physics enables spatial separation of the energy fluxes with positive and negative group velocity.
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- 2022
25. Tailored Topological Edge Waves via Chiral Hierarchical Metamaterials
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De Ponti, Jacopo M., Iorio, Luca, Chaplain, Gregory J., Corigliano, Alberto, Craster, Richard V., and Ardito, Raffaele
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Physics - Classical Physics ,Physics - Applied Physics - Abstract
Precise manipulation of the direction and re-direction of vibrational wave energy is a key demand in wave physics and engineering. We consider the paradigm of a finite frame-like structure and the requirement to channel energy away from critical regions, leaving them vibration-free, and redirect energy along edges towards energy concentrators for damping or energy harvesting. We design an exemplar frame metamaterial, combining two distinct areas of wave physics. Firstly, topological edge states taking an unconventional tetrachiral lattice. We control these highly localised protected edge states leveraging a hierarchy of scales through the addition of micro-resonators that impose tuneable symmetry breaking and reconfigurable mass. This allows us to achieve precise positional control in the macro-scale frame lattice, thereby opening opportunities for robust signal transport and vibration control. Experiments, theory, simulation are all utilised to provide a comprehensive analysis and interpretation of the physics.
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- 2022
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26. Are severity and location of facial trauma risk factors for cervical spine injuries? 10-year analysis based on the use of the AO spine injury classification and the comprehensive facial injury (CFI) score
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Canzi, G., De Ponti, E., Spota, A., Mangini, G., De Simone, E., Cioffi, S. P. B., Altomare, M., Bini, R., Virdis, F., Cimbanassi, S., Chiara, O., Sozzi, D., and Novelli, G.
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- 2024
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27. A global analysis of implants and replacements of pacemakers and cardioverter-defibrillators before, during, and after the COVID-19 pandemic in Italy
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Zecchin, Massimo, Ciminello, Enrico, Mari, Veronica, Proclemer, Alessandro, D’Onofrio, Antonio, Zanotto, Gabriele, De Ponti, Roberto, Capovilla, Teresa Maria, Laricchiuta, Paola, Biondi, Alessia, Sampaolo, Letizia, Pascucci, Simona, Sinagra, Gianfranco, Boriani, Giuseppe, Carrani, Eugenio, and Torre, Marina
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- 2024
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28. Healthcare-associated infections and antimicrobial use in acute care hospitals: a point prevalence survey in Lombardy, Italy, in 2022
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Antonio Antonelli, Maria Elena Ales, Greta Chiecca, Zeno Dalla Valle, Emanuele De Ponti, Danilo Cereda, Lucia Crottogini, Cristina Renzi, Carlo Signorelli, and Matteo Moro
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Point prevalence survey ,Healthcare associated infection ,Antimicrobial use ,Antimicrobial stewardship ,Surveillance ,Infection prevention and control ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Healthcare-Associated Infections (HAIs) are a global public health issue, representing a significant burden of disease that leads to prolonged hospital stays, inappropriate use of antimicrobial drugs, intricately linked to the development of resistant microorganisms, and higher costs for healthcare systems. The study aimed to measure the prevalence of HAIs, the use of antimicrobials, and assess healthcare- and patient-related risk factors, to help identify key intervention points for effectively reducing the burden of HAIs. Methods A total of 28 acute care hospitals in the Lombardy region, Northern Italy, participated in the third European Point Prevalence Survey (PPS-3) coordinated by ECDC for the surveillance of HAIs in acute care hospitals (Protocol 6.0). Results HAIs were detected in 1,259 (10.1%, 95% CI 9.6–10.7%) out of 12,412 enrolled patients. 1,385 HAIs were reported (1.1 HAIs per patient on average). The most common types of HAIs were bloodstream infections (262 cases, 18.9%), urinary tract infections (237, 17.1%), SARS-CoV-2 infections (236, 17.0%), pneumonia and lower respiratory tract infections (231, 16.7%), and surgical site infections (152, 11.0%). Excluding SARS-CoV-2 infections, the overall prevalence of HAIs was 8.4% (95% CI 7.9–8.9%). HAIs were significantly more frequent in patients hospitalized in smaller hospitals and in intensive care units (ICUs), among males, advanced age, severe clinical condition and in patients using invasive medical devices. Overall, 5,225 patients (42.1%, 95% CI 41.3–43.0%) received systemic antimicrobial therapy. According to the WHO’s AWaRe classification, the Access group accounted for 32.7% of total antibiotic consumption, while Watch and Reserve classes accounted for 57.0% and 5.9% respectively. From a microbiological perspective, investigations were conducted on only 64% of the HAIs, showing, however, a significant pattern of antibiotic resistance. Conclusions The PPS-3 in Lombardy, involving data collection on HAIs and antimicrobial use in acute care hospitals, highlights the crucial need for a structured framework serving both as a valuable benchmark for individual hospitals and as a foundation to effectively channel interventions to the most critical areas, prioritizing future regional health policies to reduce the burden of HAIs.
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- 2024
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29. Analytical solutions for Bloch waves in resonant phononic crystals: Deep subwavelength energy splitting and mode steering between topologically protected interfacial and edge states
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Wiltshaw, Richard, De Ponti, Jacopo Maria, and Craster, Richard Vaughan
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Physics - Classical Physics ,Mathematical Physics ,Physics - Computational Physics - Abstract
We derive analytical solutions based on singular Green's functions, which enable efficient computations of scattering simulations or Floquet-Bloch dispersion relations for waves propagating through an elastic plate, whose surface is patterned by periodic arrays of elastic beams. Our methodology is versatile and allows us to solve a range of problems regarding arrangements of multiple beams per primitive cell, over Bragg to deep-subwavelength scales; we cross-verify against finite element numerical simulations to gain further confidence in our approach, which relies upon the hypothesis of Euler-Bernoulli beam theory considerably simplifying continuity conditions such that each beam can be replaced by point forces and moments applied to the neutral plane of the plate. The representations of Green's functions by Fourier series or Fourier transforms readily follows, yielding rapid and accurate analytical schemes. The accuracy and flexibility of our solutions are demonstrated by engineering topologically non-trivial states, from primitive cells with broken spatial symmetries, following the phononic analogue of the Quantum Valley Hall Effect (QVHE). Topologically protected states are produced and coexist along: interfaces between adjoining chiral-mirrored bulk media and edges between one such chiral bulk and the surrounding bare elastic plate, allowing topological circuits to be designed with robust waveguiding; these topologically non-trivial states exist within near flexural resonances of the constituent beams of the phononic crystal, and hence can be tuned into a deep-subwavelength regime.
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- 2022
30. A Graded Metamaterial for Broadband and High-capability Piezoelectric Energy Harvesting
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Zhao, Bao, Thomsen, Henrik R., De Ponti, Jacopo M., Riva, Emanuele, Van Damme, Bart, Bergamini, Andrea, Chatzi, Eleni, and Colombi, Andrea
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Physics - Applied Physics - Abstract
This work studies a broadband graded metamaterial, which integrates the piezoelectric energy harvesting function targeting low-frequency structural vibrations, lying below 100 Hz. The device combines a graded metamaterial with beam-like resonators, piezoelectric patches and a self-powered piezoelectric interface circuit for energy harvesting. Based on the mechanical and electrical lumped parameters, an integrated model is proposed to investigate the power performance of the proposed design. Thorough numerical simulations were conducted to analyse the spatial frequency separation capacity and the slow-wave phenomenon of the graded metamaterial for broadband and high-capability piezoelectric energy harvesting. Experiments with realistic vibration sources show that the harvested power of the proposed design yields a five-fold increase with respect to conventional harvesting solutions based on single cantilever harvesters. Our results reveal the significant potential on exploitation of graded metamaterials for energy-efficient vibration-powered devices.
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- 2022
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31. Observation of Elastic Orbital Angular Momentum Transfer: Coupling Flexural Waves in Partially Submerged Pipes to Acoustic Waves in Fluids
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Chaplain, G. J., De Ponti, J. M., and Starkey, T. A.
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Physics - Applied Physics - Abstract
Research into the orbital angular momentum carried by helical wave-fronts has been dominated by the fields of electromagnetism and acoustics, owing to its practical utility in sensing, communication and tweezing. Despite the huge research effort across the wave community, only recently has elastic orbital angular momentum been theoretically shown to exhibit similar properties. Here we experimentally observe the transfer of elastic orbital angular momentum from a hollow elastic pipe to a fluid in which the pipe is partially submerged, in an elastic analogue of Durnin's slit-ring experiment for optical beams. This transfer is achieved by coupling the dilatational component of guided flexural waves in the pipe with the pressure field in the fluid; the circumferential distribution of the normal stress in the pipe acts as a continuous phased pressure source in the fluid resulting in the generation of Bessel-like acoustic beams. This demonstration has implications for future research into a new regime of orbital angular momentum for elastic waves, as well providing a new method to excite acoustic beams that carry orbital angular momentum that could create a new paradigm shift for acoustic tweezing., Comment: 11 Pages, 5 figures
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- 2022
32. Grossman–Hart–Moore Goes to Italy: Rethinking the Boundaries of the Firm
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De Ponti, Pietro, Gattai, Valeria, and Natale, Piergiovanna
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- 2023
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33. The impact of oocyte central granularity on ICSI practice: developmental competence of dysmorphic and morphologically normal companion oocytes
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Buratini, Jose, Moutier, Clarissa, Guglielmo, Maria Cristina, Turchi, Diana, Webb, Robert, De Ponti, Elena, Renzini, Mario Mignini, and Canto, Mariabeatrice Dal
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- 2023
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34. Elastic three-dimensional metaframe for selective wave filtering and polarization control
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De Ponti, Jacopo M., Riva, Emanuele, Braghin, Francesco, and Ardito, Raffaele
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Physics - Classical Physics - Abstract
We experimentally achieve selective wave filtering and polarization control in a three-dimensional elastic frame embedding local resonators. By connecting multi-resonating elements to a frame structure, a complete low-frequency, subwavelength bandgap with strong selective filtering properties is obtained. Theory and experiments demonstrate the metaframe capability to selectively stop transverse waves while allowing longitudinal wave propagation, as in 'fluid-like' elasticity. This peculiar behaviour, together with the complete bandgap structure, may open opportunities in the context of wave control, envisaging concurrent applications for three-dimensional filters and elastic wave polarizers.
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- 2021
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35. Elastic Orbital Angular Momentum
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Chaplain, G. J., De Ponti, J. M., and Craster, R. V.
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Condensed Matter - Soft Condensed Matter - Abstract
We identify that flexural guided elastic waves in elastic pipes carry a well-defined orbital angular momentum associated with the compressional dilatational potential. This enables the transfer of elastic orbital angular momentum, that we numerically demonstrate, through the coupling of the compressional potential in a pipe to the acoustic pressure field in a surrounding fluid in contact with the pipe., Comment: 5 pages, 3 figures plus supplemental material
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- 2021
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36. The Elastic Spiral Phase Pipe
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Chaplain, Gregory J. and De Ponti, Jacopo M.
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Physics - Classical Physics - Abstract
We design a device for the passive mode conversion of guided, axisymmetric, ultrasonic waves in hollow elastic pipes into arbitrary non-axisymmetric flexural waves that have a constant angular profile along the pipe axis. To achieve this we create an elastic analogue to optical spiral phase plates - the elastic spiral phase pipe. Three possible configurations of the elastic spiral phase pipe are presented which allow the efficient generation of non-axisymmetric flexural waves from an axisymmetric, longitudinal forcing. The theory leverages the dispersive nature of the guided elastic waves that are supported in pipes through a defined relative refractive index. As such we include a spectral collocation method used to aid the design of the elastic spiral phase pipe that is corroborated with numerical simulations and then experimentally verified., Comment: 34 pages, 10 figures
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- 2021
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37. Short-term pain control after palliative radiotherapy for uncomplicated bone metastases: a prospective cohort study
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Bianchi, Sofia Paola, Faccenda, Valeria, Pacifico, Pietro, Parma, Gaia, Saufi, Sara, Ferrario, Federica, Belmonte, Maria, Sala, Luca, De Ponti, Elena, Panizza, Denis, and Arcangeli, Stefano
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- 2024
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38. Cheeger bounds on spin-two fields
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De Luca, G. Bruno, De Ponti, Nicolò, Mondino, Andrea, and Tomasiello, Alessandro
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High Energy Physics - Theory ,General Relativity and Quantum Cosmology ,Mathematical Physics ,Mathematics - Differential Geometry ,Mathematics - Metric Geometry - Abstract
We consider gravity compactifications whose internal space consists of small bridges connecting larger manifolds, possibly noncompact. We prove that, under rather general assumptions, this leads to a massive spin-two field with very small mass. The argument involves a recently-noticed relation to Bakry--\'Emery geometry, a version of the so-called Cheeger constant, and the theory of synthetic Ricci lower bounds. The latter technique allows generalizations to non-smooth spaces such as those with D-brane singularities. For AdS$_d$ vacua with a bridge admitting an AdS$_{d+1}$ interpretation, the holographic dual is a CFT$_d$ with two CFT$_{d-1}$ boundaries. The ratio of their degrees of freedom gives the graviton mass, generalizing results obtained by Bachas and Lavdas for $d=4$. We also prove new bounds on the higher eigenvalues. These are in agreement with the spin-two swampland conjecture in the regime where the background is scale-separated; in the opposite regime we provide examples where they are in naive tension with it., Comment: 61 pages, 4 figures
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- 2021
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39. The irresistible challenge of substrate mapping in atrial reentrant tachycardia
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De Ponti, Roberto and Arnò, Carlo
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- 2023
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40. Reinforcement learning optimisation for graded metamaterial design using a physical-based constraint on the state representation and action space
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Luca Rosafalco, Jacopo Maria De Ponti, Luca Iorio, Richard V. Craster, Raffaele Ardito, and Alberto Corigliano
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Medicine ,Science - Abstract
Abstract The energy harvesting capability of a graded metamaterial is maximised via reinforcement learning (RL) under realistic excitations at the microscale. The metamaterial consists of a waveguide with a set of beam-like resonators of variable length, with piezoelectric patches, attached to it. The piezo-mechanical system is modelled through equivalent lumped parameters determined via a general impedance analysis. Realistic conditions are mimicked by considering either magnetic loading or random excitations, the latter scenario requiring the enhancement of the harvesting capability for a class of forcing terms with similar but different frequency content. The RL-based optimisation is empowered by using the physical understanding of wave propagation in a such local resonance system to constrain the state representation and the action space. The procedure outcomes are compared against grading rules optimised through genetic algorithms. While genetic algorithms are more effective in the deterministic setting featuring the application of magnetic loading, the proposed RL-based proves superior in the inherently stochastic setting of the random excitation scenario.
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- 2023
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41. Selective mode conversion and rainbow trapping via graded elastic waveguides
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De Ponti, Jacopo M., Iorio, Luca, Riva, Emanuele, Ardito, Raffaele, Braghin, Francesco, and Corigliano, Alberto
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Physics - Classical Physics ,Physics - Applied Physics - Abstract
We experimentally achieve wave mode conversion and rainbow trapping in an elastic waveguide loaded with an array of resonators. Rainbow trapping is a phenomenon that induces wave confinement as a result of a spatial variation of the wave velocity, here promoted by gently varying the length of consecutive resonators. By breaking the geometrical symmetry of the waveguide, we combine the wave speed reduction with a reflection mechanism that mode-converts flexural waves impinging on the array into torsional waves travelling along opposite directions. The framework presented herein may open opportunities in the context of wave manipulation through the realization of structural components with concurrent wave conversion and energy trapping capabilities.
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- 2021
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42. Indeterminacy estimates, eigenfunctions and lower bounds on Wasserstein distances
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De Ponti, Nicolò and Farinelli, Sara
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Mathematics - Differential Geometry ,Mathematics - Functional Analysis ,Mathematics - Metric Geometry - Abstract
In the paper we prove two inequalities in the setting of ${\sf RCD}(K,\infty)$ spaces using similar techniques. The first one is an indeterminacy estimate involving the $p$-Wasserstein distance between the positive part and the negative part of an $L^{\infty}$ function and the measure of the interface between the positive part and the negative part. The second one is a conjectured lower bound on the $p$-Wasserstein distance between the positive and negative parts of a Laplace eigenfunction., Comment: Major update. Structure of the proof simplified. Added new results on indeterminacy estimates for transport distances. The inequality between $p$-Wasserstein and $p$-Hellinger distances for $p>2$ is now not needed: it has been removed and will be part of a future project
- Published
- 2021
43. Atrial High-Rate Episodes and Subclinical Atrial Fibrillation: State of the Art and Clinical Questions with Complex Solutions
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Carola Griffith Brookles, Roberto De Ponti, Vincenzo Russo, Matteo Ziacchi, Gemma Pelargonio, Michela Casella, Maurelio Lauretti, Manola Vilotta, Sakis Themistoclakis, Antonio D’Onofrio, Giuseppe Boriani, Matteo Anselmino, and on behalf of AIAC
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atrial high-rate episode ,subclinical atrial fibrillation ,cardiac implantable electronic devices ,thromboembolic risk ,cognitive impairment ,anticoagulation ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Atrial high-rate episodes (AHREs) and subclinical atrial fibrillation (AF) are frequently registered in asymptomatic patients with cardiac implantable electronic devices (CIEDs) and insertable cardiac monitors (ICMs). While an increased risk of thromboembolic events (e.g., stroke) and benefits from anticoagulation have been widely assessed in the setting of clinical AF, concerns persist about optimal clinical management of subclinical AF/AHREs. As a matter of fact, an optimal threshold of subclinical episodes’ duration to predict stroke risk is still lacking and recently published randomized clinical trials assessing the impact of anticoagulation on thromboembolic events in this specific setting have shown contrasting results. The aim of this review is to summarize current evidence regarding classification and clinical impact of subclinical AF/AHREs and to discuss the latest evidence regarding the potential benefit of anticoagulation in this setting, highlighting which clinical questions are still unanswered.
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- 2024
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44. Educational value of international and intercultural differences in prescribing: the international and interprofessional student-run clinic project
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Bakkum, Michiel J., Donker, Erik M., Spitaleri Timpone, Pietro, Hagen, Charlotte A. M., Richir, Milan C., van Agtmael, Michiel A., De Ponti, Fabrizio, and Tichelaar, Jelle
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- 2023
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45. Updating approach for lexicographic optimization-based planning to improve cervical cancer plan quality
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Paolo Caricato, Sara Trivellato, Roberto Pellegrini, Gianluca Montanari, Martina Camilla Daniotti, Bianca Bordigoni, Valeria Faccenda, Denis Panizza, Sofia Meregalli, Elisa Bonetto, Peter Voet, Stefano Arcangeli, and Elena De Ponti
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Lexicographic optimization ,Automated planning ,Cervical cancer ,VMAT ,Plan quality ,Plan comparison ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background To investigate the capability of a not-yet commercially available fully automated lexicographic optimization (LO) planning algorithm, called mCycle (Elekta AB, Stockholm, Sweden), to further improve the plan quality of an already-validated Wish List (WL) pushing on the organs-at-risk (OAR) sparing without compromising target coverage and plan delivery accuracy. Material and Methods Twenty-four mono-institutional consecutive cervical cancer Volumetric-Modulated Arc Therapy (VMAT) plans delivered between November 2019 and April 2022 (50 Gy/25 fractions) have been retrospectively selected. In mCycle the LO planning algorithm was combined with the a-priori multi-criterial optimization (MCO). Two versions of WL have been defined to reproduce manual plans (WL01), and to improve the OAR sparing without affecting minimum target coverage and plan delivery accuracy (WL02). Robust WLs have been tuned using a subset of 4 randomly selected patients. The remaining plans have been automatically re-planned by using the designed WLs. Manual plans (MP) and mCycle plans (mCP01 and mCP02) were compared in terms of dose distributions, complexity, delivery accuracy, and clinical acceptability. Two senior physicians independently performed a blind clinical evaluation, ranking the three competing plans. Furthermore, a previous defined global quality index has been used to gather into a single score the plan quality evaluation. Results The WL tweaking requests 5 and 3 working days for the WL01 and the WL02, respectively. The re-planning took in both cases 3 working days. mCP01 best performed in terms of target coverage (PTV V95% (%): MP 98.0 [95.6–99.3], mCP01 99.2 [89.7–99.9], mCP02 96.9 [89.4–99.5]), while mCP02 showed a large OAR sparing improvement, especially in the rectum parameters (e.g., Rectum D50% (Gy): MP 41.7 [30.2–47.0], mCP01 40.3 [31.4–45.8], mCP02 32.6 [26.9–42.6]). An increase in plan complexity has been registered in mCPs without affecting plan delivery accuracy. In the blind comparisons, all automated plans were considered clinically acceptable, and mCPs were preferred over MP in 90% of cases. Globally, automated plans registered a plan quality score at least comparable to MP. Conclusions This study showed the flexibility of the Lexicographic approach in creating more demanding Wish Lists able to potentially minimize toxicities in RT plans.
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- 2023
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46. Harmonic functions and gravity localization
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G. Bruno De Luca, Nicolò De Ponti, Andrea Mondino, and Alessandro Tomasiello
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Classical Theories of Gravity ,Flux Compactifications ,Spacetime Singularities ,Superstring Vacua ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract In models with extra dimensions, matter particles can be easily localized to a ‘brane world’, but gravitational attraction tends to spread out in the extra dimensions unless they are small. Strong warping gradients can help localize gravity closer to the brane. In this note we give a mathematically rigorous proof that the internal wave-function of the massless graviton is constant as an eigenfunction of the weighted Laplacian, and hence is a power of the warping as a bound state in an analogue Schrödinger potential. This holds even in presence of singularities induced by thin branes. We also reassess the status of AdS vacuum solutions where the graviton is massive. We prove a bound on scale separation for such models, as an application of our recent results on KK masses. We also use them to estimate the scale at which gravity is localized, without having to compute the spectrum explicitly. For example, we point out that localization can be obtained at least up to the cosmological scale in string/M-theory solutions with infinite-volume Riemann surfaces; and in a known class of N $$ \mathcal{N} $$ = 4 models, when the number of NS5- and D5-branes is roughly equal.
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- 2023
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47. Outcome of patients with stage I immature teratoma after surveillance or adjuvant chemotherapy
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Giuseppe Marino, Tommaso Grassi, Elena De Ponti, Serena Negri, Filippo Testa, Daniela Giuliani, Martina Delle Marchette, Cristina Dell’Oro, Diletta Fumagalli, Gianluca Donatiello, Giulia Besana, Liliana Marchetta, Cristina Maria Bonazzi, Andrea Alberto Lissoni, Fabio Landoni, and Robert Fruscio
- Subjects
immature teratoma of the ovary ,germ cell tumor ,chemotherapy ,oncologic outcome ,ovarian cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
ObjectiveImmature teratomas are rare malignant ovarian germ cell tumours, typically diagnosed in young women, where fertility-sparing surgery is the treatment of choice. The role of adjuvant chemotherapy in stage I disease remains controversial. We evaluated the impact of surveillance versus chemotherapy on the recurrence rate in stage I immature teratomas.MethodsWe collected a single centre retrospective series of patients with stage I immature teratomas treated with fertility-sparing surgery at San Gerardo Hospital, Monza, Italy, between 1980 and 2019. Potential risk factors for recurrence were investigated by multivariate logistic regression.ResultsOf the 74 patients included, 12% (9/74) received chemotherapy, while 88% (65/74) underwent surveillance. Median follow-up was 188 months. No difference in recurrence was found in stage IA/IB and IC immature teratomas [10% (6/60) vs. 28.6% (4/14) (P=0.087)], grade 1, grade 2, and grade 3 [7.1% (2/28) vs. 14.3% (4/28) vs. 22.2% (4/18) (p=0.39)], and surveillance versus chemotherapy groups [13.9% (9/65) vs. 11.1% (1/9)) (p = 1.00)]. In univariate analysis, the postoperative approach had no impact on recurrence. The 5-year disease-free survival was 87% and 90% in the surveillance and chemotherapy groups, respectively; the overall survival was 100% in both cohorts.ConclusionsOur results support the feasibility of surveillance in stage I immature teratomas. Adjuvant chemotherapy may be reserved for relapses. However, the potential benefit of chemotherapy should be discussed, especially for high-risk tumours. Prospective series are warranted to confirm our findings.What is already known on this topicTo date, no consensus has been reached regarding the role of adjuvant chemotherapy in stage I immature teratomas of the ovary. Some studies suggest that only surveillance is an acceptable choice. However, guidelines are not conclusive on this topic.What this study addsNo difference in terms of recurrence was observed between the surveillance and the adjuvant chemotherapy group. All patients who relapsed were successfully cured with no disease-related deaths.How this study might affect research, practice or policyAdjuvant chemotherapy should be appropriately discussed with patients. However, it may be reserved for relapse according to our data.
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- 2024
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48. Entropy-Transport distances between unbalanced metric measure spaces
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De Ponti, Nicoló and Mondino, Andrea
- Subjects
Mathematics - Metric Geometry ,Mathematics - Optimization and Control - Abstract
Inspired by the recent theory of Entropy-Transport problems and by the $\mathbf{D}$-distance of Sturm on normalised metric measure spaces, we define a new class of complete and separable distances between metric measure spaces of possibly different total mass. We provide several explicit examples of such distances, where a prominent role is played by a geodesic metric based on the Hellinger-Kantorovich distance. Moreover, we discuss some limiting cases of the theory, recovering the "pure transport" $\mathbf{D}$-distance and introducing a new class of "pure entropic" distances. We also study in detail the topology induced by such Entropy-Transport metrics, showing some compactness and stability results for metric measure spaces satisfying Ricci curvature lower bounds in a synthetic sense., Comment: 39 pages. Added a section with a comparison with the conic Gromov-Wasserstein distance. Some other minor improvements. Final version, to appear on "Probability Theory and Related Fields"
- Published
- 2020
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49. The equality case in Cheeger's and Buser's inequalities on $\mathsf{RCD}$ spaces
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De Ponti, Nicolò, Mondino, Andrea, and Semola, Daniele
- Subjects
Mathematics - Functional Analysis ,Mathematics - Differential Geometry ,Mathematics - Metric Geometry - Abstract
We prove that the sharp Buser's inequality obtained in the framework of $\mathsf{RCD}(1,\infty)$ spaces by the first two authors is rigid, i.e. equality is obtained if and only if the space splits isomorphically a Gaussian. The result is new even in the smooth setting. We also show that the equality in Cheeger's inequality is never attained in the setting of $\mathsf{RCD}(K,\infty)$ spaces with finite diameter or positive curvature, and we provide several examples of spaces with Ricci curvature bounded below where these assumptions are not satisfied and the equality is attained., Comment: Added new results: the discussion on Cheeger's inequality now fits into the study of a family of inequalities relating eigenvalues of the p-Laplacian. To appear on Journal of Functional Analysis
- Published
- 2020
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50. Topological rainbow trapping for elastic energy harvesting in graded SSH systems
- Author
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Chaplain, Gregory J., De Ponti, Jacopo M., Aguzzi, Giulia, Colombi, Andrea, and Craster, Richard V.
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Physics - Applied Physics ,Physics - Classical Physics - Abstract
We amalgamate two fundamental designs from distinct areas of wave control in physics, and place them in the setting of elasticity. Graded elastic metasurfaces, so-called metawedges, are combined with the now classical Su-Schrieffer-Heeger (SSH) model from the field of topological insulators. The resulting structures form one-dimensional graded-SSH-metawedges that support multiple, simultaneous, topologically protected edge states. These robust, enhanced localised modes are leveraged for applications in elastic energy harvesting using the piezoelectric effect. The designs we develop are first motivated by applying the SSH model to mass-loaded Kirchhoff-Love thin elastic plates. We then extend these ideas to using graded resonant rods, and create SSH models, coupled to elastic beams and full elastic half-spaces.
- Published
- 2020
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