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1. Integration studies of RF solid-state generators in the electrical system of NBTF experiments and ITER HNB

Author

Casagrande, R., Maistrello, A., Recchia, M., De Nardi, M., Bigi, M., Zanotto, L., Boldrin, M., and Decamps, H.

Subjects
Physics - Plasma Physics, Physics - Accelerator Physics
Abstract

SPIDER operation, started in 2018, pointed out performance-limiting issues caused by the technology employed in RF generators, based on tetrode free-running oscillators. One of these limits, namely the onset of frequency instabilities, prevented operation at the full rated power of 200 kW. In addition, tetrodes require high voltage to operate, which translates to risk of flashovers and the necessity to perform conditioning procedures, limiting the overall reliability. These disadvantages, combined with the positive experience gained in the meanwhile on smaller facilities with solid state amplifiers, led to the proposal of a complete re-design of the radiofrequency power supplies. This paper describes the modelling activities used to define specifications and design criteria of the solid-state amplifiers for SPIDER and MITICA, which can be directly transposed to the ITER HNB units when their functionality is proven. We detail the topology of the generators, consisting of class D amplifier modules combined to achieve the required 200 kW, which design is mainly driven by the necessity to deliver nominal power to the ion source, mitigate the risk of obsolescence, and improve the reliability through modularity. Due to the non-standard application, we gave particular focus to the integration of generators in the RF systems of SPIDER and MITICA. Numerical analyses were performed to verify the impact of harmonic distortion on transmission line and RF load components, to address the effect of mutual coupling between RF circuits on the generator output modulation, and to assess the magnitude of common mode currents in the electric system. These studies, as well as the experience gained from SPIDER operation, helped to define dedicated circuit design provisions and control strategies, which are currently being implemented in the detailed design and construction phase of the new RF amplifiers.

Published
2023
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2. Lessons learned after three years of SPIDER operation and the first MITICA integrated tests

Author

Marcuzzi, D., Toigo, V., Boldrin, M., Chitarin, G., Bello, S. Dal, Grando, L., Luchetta, A., Pasqualotto, R., Pavei, M., Serianni, G., Zanotto, L., Agnello, R., Agostinetti, P., Agostini, M., Aprile, D., Barbisan, M., Battistella, M., Berton, G., Bigi, M., Brombin, M., Candela, V., Candeloro, V., Canton, A., Casagrande, R., Cavallini, C., Cavazzana, R., Cordaro, L., Cruz, N., Palma, M. Dalla, Dan, M., De Lorenzi, A., Delogu, R., De Muri, M., De Nardi, M., Denizeau, S., Fadone, M., Fellin, F., Ferro, A., Gaio, E., Gasparrini, C., Gnesotto, F., Jain, P., La Rosa, A., Lopez-Bruna, D., Lorenzini, R., Maistrello, A., Manduchi, G., Manfrin, S., Marconato, N., Mario, I., Martini, G., Milazzo, R., Patton, T., Peruzzo, S., Pilan, N., Pimazzoni, A., Poggi, C., Pomaro, N., Pouradier-Duteil, B., Recchia, M., Rigoni-Garola, A., Rizzetto, D., Rizzolo, A., Santoro, F., Sartori, E., Segalini, B., Shepherd, A., Siragusa, M., Sonato, P., Sottocornola, A., Spada, E., Spagnolo, S., Spolaore, M., Taliercio, C., Tinti, P., Tomsič, P., Trevisan, L., Ugoletti, M., Valente, M., Valisa, M., Veronese, F., Vignando, M., Zaccaria, P., Zagorski, R., Zaniol, B., Zaupa, M., Zuin, M., Cavenago, M., Boilson, D., Rotti, C., Decamps, H., Geli, F., Sharma, A., Veltri, P., Zacks, J., Simon, M., Paolucci, F., Garbuglia, A., Gutierrez, D., Masiello, A., Mico, G., Labate, C., Readman, P., Bragulat, E., Bailly-Maitre, L., Gomez, G., Kouzmenko, G., Albajar, F., Kashiwagi, M., Tobari, H., Kojima, A., Murayama, M., Hatakeyama, S., Oshita, E., Maejima, T., Shibata, N., Yamashita, Y., Watanabe, K., Singh, N. P., Singh, M. J., Dhola, H., Fantz, U., Heinemann, B., Wimmer, C., Wünderlich, D., Tsumori, K., Croci, G., Gorini, G., Muraro, A., Rebai, M., Tardocchi, M., Giacomelli, L., Rigamonti, D., Taccogna, F., Bruno, D., Rutigliano, M., Longo, S., Deambrosis, S., Miorin, E., Montagner, F., Tonti, A., and Panin, F.

Subjects
Physics - Plasma Physics, Physics - Accelerator Physics
Abstract

ITER envisages the use of two heating neutral beam injectors plus an optional one as part of the auxiliary heating and current drive system. The 16.5 MW expected neutral beam power per injector is several notches higher than worldwide existing facilities. A Neutral Beam Test Facility (NBTF) was established at Consorzio RFX, exploiting the synergy of two test beds, SPIDER and MITICA. SPIDER is dedicated to developing and characterizing large efficient negative ion sources at relevant parameters in ITER-like conditions: source and accelerator located in the same vacuum where the beam propagates, immunity to electromagnetic interferences of multiple radio-frequency (RF) antennas, avoidance of RF-induced discharges on the outside of the source. Three years of experiments on SPIDER have addressed to the necessary design modifications to enable full performances. The source is presently under a long shut-down phase to incorporate learnings from the experimental campaign. Parallelly, developments on MITICA, the full-scale prototype of the ITER NBI featuring a 1 MV accelerator and ion neutralization, are underway including manufacturing of in-vessel components, while power supplies and auxiliary plants are already under final testing and commissioning. Integration, commissioning and tests of the 1MV power supplies are essential for this first-of-kind system, unparalleled both in research and industry field. The integrated test to confirm 1MV output by combining invertor systems, DC generators and transmission lines extracted errors/accidents in some components. To realize a concrete system for ITER, solutions for the repair and the improvement of the system were developed. Hence, NBTF is emerging as a necessary facility, due to the large gap with existing injectors, effectively dedicated to identify issues and find solutions to enable successful ITER NBI operations in a time bound fashion.

Published
2023
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4. Highlights of recent SPIDER results and improvements

Author

Sartori, E, Agnello, R, Agostini, M, Barbisan, M, Bigi, M, Boldrin, M, Brombin, M, Candeloro, V, Casagrande, R, Dal Bello, S, Dan, M, Pouradier Duteil, B, Fadone, M, Grando, L, Jain, P, Maistrello, A, Mario, I, Pasqualotto, R, Pavei, M, Pimazzoni, A, Poggi, C, Rizzolo, A, Shepherd, A, Ugoletti, M, Veltri, P, Zaniol, B, Agostinetti, P, Aprile, D, Berton, G, Cavallini, C, Cavenago, M, Chitarin, G, Croci, G, Delogu, R, De Muri, M, De Nardi, M, Denizeau, S, Fellin, F, Ferro, A, Gaio, E, Gasparrini, C, Luchetta, A, Lunardon, F, Manduchi, G, Marconato, N, Marcuzzi, D, Mccormack, O, Milazzo, R, Muraro, A, Patton, T, Pilan, N, Recchia, M, Rigoni-Garola, A, Santoro, F, Segalini, B, Siragusa, M, Spolaore, M, Taliercio, C, Toigo, V, Zaccaria, P, Zagorski, R, Zanotto, L, Zaupa, M, Zuin, M, Serianni, G, Sartori E., Agnello R., Agostini M., Barbisan M., Bigi M., Boldrin M., Brombin M., Candeloro V., Casagrande R., Dal Bello S., Dan M., Pouradier Duteil B., Fadone M., Grando L., Jain P., Maistrello A., Mario I., Pasqualotto R., Pavei M., Pimazzoni A., Poggi C., Rizzolo A., Shepherd A., Ugoletti M., Veltri P., Zaniol B., Agostinetti P., Aprile D., Berton G., Cavallini C., Cavenago M., Chitarin G., Croci G., Delogu R., De Muri M., De Nardi M., Denizeau S., Fellin F., Ferro A., Gaio E., Gasparrini C., Luchetta A., Lunardon F., Manduchi G., Marconato N., Marcuzzi D., McCormack O., Milazzo R., Muraro A., Patton T., Pilan N., Recchia M., Rigoni-Garola A., Santoro F., Segalini B., Siragusa M., Spolaore M., Taliercio C., Toigo V., Zaccaria P., Zagorski R., Zanotto L., Zaupa M., Zuin M., Serianni G., Sartori, E, Agnello, R, Agostini, M, Barbisan, M, Bigi, M, Boldrin, M, Brombin, M, Candeloro, V, Casagrande, R, Dal Bello, S, Dan, M, Pouradier Duteil, B, Fadone, M, Grando, L, Jain, P, Maistrello, A, Mario, I, Pasqualotto, R, Pavei, M, Pimazzoni, A, Poggi, C, Rizzolo, A, Shepherd, A, Ugoletti, M, Veltri, P, Zaniol, B, Agostinetti, P, Aprile, D, Berton, G, Cavallini, C, Cavenago, M, Chitarin, G, Croci, G, Delogu, R, De Muri, M, De Nardi, M, Denizeau, S, Fellin, F, Ferro, A, Gaio, E, Gasparrini, C, Luchetta, A, Lunardon, F, Manduchi, G, Marconato, N, Marcuzzi, D, Mccormack, O, Milazzo, R, Muraro, A, Patton, T, Pilan, N, Recchia, M, Rigoni-Garola, A, Santoro, F, Segalini, B, Siragusa, M, Spolaore, M, Taliercio, C, Toigo, V, Zaccaria, P, Zagorski, R, Zanotto, L, Zaupa, M, Zuin, M, Serianni, G, Sartori E., Agnello R., Agostini M., Barbisan M., Bigi M., Boldrin M., Brombin M., Candeloro V., Casagrande R., Dal Bello S., Dan M., Pouradier Duteil B., Fadone M., Grando L., Jain P., Maistrello A., Mario I., Pasqualotto R., Pavei M., Pimazzoni A., Poggi C., Rizzolo A., Shepherd A., Ugoletti M., Veltri P., Zaniol B., Agostinetti P., Aprile D., Berton G., Cavallini C., Cavenago M., Chitarin G., Croci G., Delogu R., De Muri M., De Nardi M., Denizeau S., Fellin F., Ferro A., Gaio E., Gasparrini C., Luchetta A., Lunardon F., Manduchi G., Marconato N., Marcuzzi D., McCormack O., Milazzo R., Muraro A., Patton T., Pilan N., Recchia M., Rigoni-Garola A., Santoro F., Segalini B., Siragusa M., Spolaore M., Taliercio C., Toigo V., Zaccaria P., Zagorski R., Zanotto L., Zaupa M., Zuin M., and Serianni G.

Abstract

Three years of experiments on SPIDER allowed characterization of the main features of the source plasma and of the negative ion beam, in the original design configuration. For the large dimensions of the source chamber, and of the extraction area, the investigation of the single-beamlet currents and of the source plasma uniformity had to be carried out to extend the knowledge gained in smaller prototype sources. The configuration of the multiple RF drivers and filter field topologies were found to cause a peculiar behavior in the plasma confinement in the drivers, creating left-right asymmetries which were also visible in the extracted negative ion currents, even after the early implementation of a new scheme of plasma-grid current send and return busbars that greatly improved performance at high filter fields. The plasma properties in the driver and expansion region as well as the positive ion energy at the extraction region were studied in different experimental conditions, and interpreted also with the support of numerical models, suggesting that an improved plasma confinement could contribute to the increase of the plasma density, and to a certain extent to a lowering of the plasma potential profile; both effects shall contribute to increase the presence of cold negative ions for the formation of low-divergence beamlets. Early results related to unwanted RF discharges on the back of the plasma source and the gas conductance of the beam source suggested the reduction of the vessel pressure as mitigation, leading to the definition of a new pumping system. The difficulties related to the simultaneous operation, stable control and high-power operation of multiple RF self-oscillating vacuum tube based RF generators were an unambiguous obstruction to the experimentation, calling for the implementation of RF solid-state amplifiers. The initial tests related to caesium management, the non-uniform plasma properties at different locations across the plasma grid, and the c

Published
2023

5. Lessons learned after three years of SPIDER operation and the first MITICA integrated tests

Author

Marcuzzi, D, Toigo, V, Boldrin, M, Chitarin, G, Dal Bello, S, Grando, L, Luchetta, A, Pasqualotto, R, Pavei, M, Serianni, G, Zanotto, L, Agnello, R, Agostinetti, P, Agostini, M, Aprile, D, Barbisan, M, Battistella, M, Berton, G, Bigi, M, Brombin, M, Candela, V, Candeloro, V, Canton, A, Casagrande, R, Cavallini, C, Cavazzana, R, Cordaro, L, Cruz, N, Dalla Palma, M, Dan, M, De Lorenzi, A, Delogu, R, De Muri, M, De Nardi, M, Denizeau, S, Fadone, M, Fellin, F, Ferro, A, Gaio, E, Gasparrini, C, Gnesotto, F, Jain, P, La Rosa, A, Lopez-Bruna, D, Lorenzini, R, Maistrello, A, Manduchi, G, Manfrin, S, Marconato, N, Mario, I, Martini, G, Milazzo, R, Patton, T, Peruzzo, S, Pilan, N, Pimazzoni, A, Poggi, C, Pomaro, N, Pouradier-Duteil, B, Recchia, M, Rigoni-Garola, A, Rizzetto, D, Rizzolo, A, Santoro, F, Sartori, E, Segalini, B, Shepherd, A, Siragusa, M, Sonato, P, Sottocornola, A, Spada, E, Spagnolo, S, Spolaore, M, Taliercio, C, Tinti, P, Tomsic, P, Trevisan, L, Ugoletti, M, Valente, M, Valisa, M, Veronese, F, Vignando, M, Zaccaria, P, Zagorski, R, Zaniol, B, Zaupa, M, Zuin, M, Cavenago, M, Boilson, D, Rotti, C, Decamps, H, Geli, F, Sharma, A, Veltri, P, Zacks, J, Simon, M, Paolucci, F, Garbuglia, A, Gutierrez, D, Masiello, A, Mico, G, Labate, C, Readman, P, Bragulat, E, Bailly-Maitre, L, Gomez, G, Kouzmenko, G, Albajar, F, Kashiwagi, M, Tobari, H, Kojima, A, Murayama, M, Hatakeyama, S, Oshita, E, Maejima, T, Shibata, N, Yamashita, Y, Watanabe, K, Singh, N, Singh, M, Dhola, H, Fantz, U, Heinemann, B, Wimmer, C, Wunderlich, D, Tsumori, K, Croci, G, Gorini, G, Muraro, A, Rebai, M, Tardocchi, M, Giacomelli, L, Rigamonti, D, Taccogna, F, Bruno, D, Rutigliano, M, Longo, S, Deambrosis, S, Miorin, E, Montagner, F, Tonti, A, Panin, F, Marcuzzi D., Toigo V., Boldrin M., Chitarin G., Dal Bello S., Grando L., Luchetta A., Pasqualotto R., Pavei M., Serianni G., Zanotto L., Agnello R., Agostinetti P., Agostini M., Aprile D., Barbisan M., Battistella M., Berton G., Bigi M., Brombin M., Candela V., Candeloro V., Canton A., Casagrande R., Cavallini C., Cavazzana R., Cordaro L., Cruz N., Dalla Palma M., Dan M., De Lorenzi A., Delogu R., De Muri M., De Nardi M., Denizeau S., Fadone M., Fellin F., Ferro A., Gaio E., Gasparrini C., Gnesotto F., Jain P., La Rosa A., Lopez-Bruna D., Lorenzini R., Maistrello A., Manduchi G., Manfrin S., Marconato N., Mario I., Martini G., Milazzo R., Patton T., Peruzzo S., Pilan N., Pimazzoni A., Poggi C., Pomaro N., Pouradier-Duteil B., Recchia M., Rigoni-Garola A., Rizzetto D., Rizzolo A., Santoro F., Sartori E., Segalini B., Shepherd A., Siragusa M., Sonato P., Sottocornola A., Spada E., Spagnolo S., Spolaore M., Taliercio C., Tinti P., Tomsic P., Trevisan L., Ugoletti M., Valente M., Valisa M., Veronese F., Vignando M., Zaccaria P., Zagorski R., Zaniol B., Zaupa M., Zuin M., Cavenago M., Boilson D., Rotti C., Decamps H., Geli F., Sharma A., Veltri P., Zacks J., Simon M., Paolucci F., Garbuglia A., Gutierrez D., Masiello A., Mico G., Labate C., Readman P., Bragulat E., Bailly-Maitre L., Gomez G., Kouzmenko G., Albajar F., Kashiwagi M., Tobari H., Kojima A., Murayama M., Hatakeyama S., Oshita E., Maejima T., Shibata N., Yamashita Y., Watanabe K., Singh N. P., Singh M. J., Dhola H., Fantz U., Heinemann B., Wimmer C., Wunderlich D., Tsumori K., Croci G., Gorini G., Muraro A., Rebai M., Tardocchi M., Giacomelli L., Rigamonti D., Taccogna F., Bruno D., Rutigliano M., Longo S., Deambrosis S., Miorin E., Montagner F., Tonti A., Panin F., Marcuzzi, D, Toigo, V, Boldrin, M, Chitarin, G, Dal Bello, S, Grando, L, Luchetta, A, Pasqualotto, R, Pavei, M, Serianni, G, Zanotto, L, Agnello, R, Agostinetti, P, Agostini, M, Aprile, D, Barbisan, M, Battistella, M, Berton, G, Bigi, M, Brombin, M, Candela, V, Candeloro, V, Canton, A, Casagrande, R, Cavallini, C, Cavazzana, R, Cordaro, L, Cruz, N, Dalla Palma, M, Dan, M, De Lorenzi, A, Delogu, R, De Muri, M, De Nardi, M, Denizeau, S, Fadone, M, Fellin, F, Ferro, A, Gaio, E, Gasparrini, C, Gnesotto, F, Jain, P, La Rosa, A, Lopez-Bruna, D, Lorenzini, R, Maistrello, A, Manduchi, G, Manfrin, S, Marconato, N, Mario, I, Martini, G, Milazzo, R, Patton, T, Peruzzo, S, Pilan, N, Pimazzoni, A, Poggi, C, Pomaro, N, Pouradier-Duteil, B, Recchia, M, Rigoni-Garola, A, Rizzetto, D, Rizzolo, A, Santoro, F, Sartori, E, Segalini, B, Shepherd, A, Siragusa, M, Sonato, P, Sottocornola, A, Spada, E, Spagnolo, S, Spolaore, M, Taliercio, C, Tinti, P, Tomsic, P, Trevisan, L, Ugoletti, M, Valente, M, Valisa, M, Veronese, F, Vignando, M, Zaccaria, P, Zagorski, R, Zaniol, B, Zaupa, M, Zuin, M, Cavenago, M, Boilson, D, Rotti, C, Decamps, H, Geli, F, Sharma, A, Veltri, P, Zacks, J, Simon, M, Paolucci, F, Garbuglia, A, Gutierrez, D, Masiello, A, Mico, G, Labate, C, Readman, P, Bragulat, E, Bailly-Maitre, L, Gomez, G, Kouzmenko, G, Albajar, F, Kashiwagi, M, Tobari, H, Kojima, A, Murayama, M, Hatakeyama, S, Oshita, E, Maejima, T, Shibata, N, Yamashita, Y, Watanabe, K, Singh, N, Singh, M, Dhola, H, Fantz, U, Heinemann, B, Wimmer, C, Wunderlich, D, Tsumori, K, Croci, G, Gorini, G, Muraro, A, Rebai, M, Tardocchi, M, Giacomelli, L, Rigamonti, D, Taccogna, F, Bruno, D, Rutigliano, M, Longo, S, Deambrosis, S, Miorin, E, Montagner, F, Tonti, A, Panin, F, Marcuzzi D., Toigo V., Boldrin M., Chitarin G., Dal Bello S., Grando L., Luchetta A., Pasqualotto R., Pavei M., Serianni G., Zanotto L., Agnello R., Agostinetti P., Agostini M., Aprile D., Barbisan M., Battistella M., Berton G., Bigi M., Brombin M., Candela V., Candeloro V., Canton A., Casagrande R., Cavallini C., Cavazzana R., Cordaro L., Cruz N., Dalla Palma M., Dan M., De Lorenzi A., Delogu R., De Muri M., De Nardi M., Denizeau S., Fadone M., Fellin F., Ferro A., Gaio E., Gasparrini C., Gnesotto F., Jain P., La Rosa A., Lopez-Bruna D., Lorenzini R., Maistrello A., Manduchi G., Manfrin S., Marconato N., Mario I., Martini G., Milazzo R., Patton T., Peruzzo S., Pilan N., Pimazzoni A., Poggi C., Pomaro N., Pouradier-Duteil B., Recchia M., Rigoni-Garola A., Rizzetto D., Rizzolo A., Santoro F., Sartori E., Segalini B., Shepherd A., Siragusa M., Sonato P., Sottocornola A., Spada E., Spagnolo S., Spolaore M., Taliercio C., Tinti P., Tomsic P., Trevisan L., Ugoletti M., Valente M., Valisa M., Veronese F., Vignando M., Zaccaria P., Zagorski R., Zaniol B., Zaupa M., Zuin M., Cavenago M., Boilson D., Rotti C., Decamps H., Geli F., Sharma A., Veltri P., Zacks J., Simon M., Paolucci F., Garbuglia A., Gutierrez D., Masiello A., Mico G., Labate C., Readman P., Bragulat E., Bailly-Maitre L., Gomez G., Kouzmenko G., Albajar F., Kashiwagi M., Tobari H., Kojima A., Murayama M., Hatakeyama S., Oshita E., Maejima T., Shibata N., Yamashita Y., Watanabe K., Singh N. P., Singh M. J., Dhola H., Fantz U., Heinemann B., Wimmer C., Wunderlich D., Tsumori K., Croci G., Gorini G., Muraro A., Rebai M., Tardocchi M., Giacomelli L., Rigamonti D., Taccogna F., Bruno D., Rutigliano M., Longo S., Deambrosis S., Miorin E., Montagner F., Tonti A., and Panin F.

Abstract

ITER envisages the use of two heating neutral beam injectors plus an optional one as part of the auxiliary heating and current drive system, to reach the desired performances during its various phases of operation. The 16.5 MW expected neutral beam power per injector is several notches higher than worldwide existing facilities. In order to enable such development, a Neutral Beam Test Facility (NBTF) was established at Consorzio RFX, exploiting the synergy of two test beds, called SPIDER and MITICA. SPIDER is dedicated developing and characterizing large efficient negative ion sources at relevant parameters in ITER-like conditions: source and accelerator located in the same vacuum where the beam propagates, immunity to electromagnetic interferences of multiple radio-frequency (RF) antennas, avoidance of RF-induced discharges on the outside of the source. Three years of experiments on SPIDER have addressed to the necessary design modifications to enable full performances. The source is presently under a long shut-down phase to incorporate learnings from the experimental campaign, in particular events/issues occurred during operation, which led to the identification of improvement opportunities/necessities (e.g. RF discharges, local burns, water leaks, other damages, configuration/design upgrades to maximize chances/margin to quest target parameters). Parallelly, developments on MITICA, the full-scale prototype of the ITER Neutral Beam Injector (NBI) featuring a 1 MV accelerator and ion neutralization, are underway including manufacturing of the beam source, accelerator and the beam line components, while power supplies and auxiliary plants, already installed, are under final testing and commissioning. Integration, commissioning and tests of the 1 MV power supplies are essential for this first-of-kind system, unparalleled both in research and industry field. 1.2 MV dc insulating tests of high voltage components were successfully completed. The integrated test to confir

Published
2023

7. Highlights of recent SPIDER results and improvements

Author

Sartori, E., primary, Agnello, R., additional, Agostini, M., additional, Barbisan, M., additional, Bigi, M., additional, Boldrin, M., additional, Brombin, M., additional, Candeloro, V., additional, Casagrande, R., additional, Dal Bello, S., additional, Dan, M., additional, Pouradier Duteil, B., additional, Fadone, M., additional, Grando, L., additional, Jain, P., additional, Maistrello, A., additional, Mario, I., additional, Pasqualotto, R., additional, Pavei, M., additional, Pimazzoni, A., additional, Poggi, C., additional, Rizzolo, A., additional, Shepherd, A., additional, Ugoletti, M., additional, Veltri, P., additional, Zaniol, B., additional, Agostinetti, P., additional, Aprile, D., additional, Berton, G., additional, Cavallini, C., additional, Cavenago, M., additional, Chitarin, G., additional, Croci, G., additional, Delogu, R., additional, De Muri, M., additional, De Nardi, M., additional, Denizeau, S., additional, Fellin, F., additional, Ferro, A., additional, Gaio, E., additional, Gasparrini, C., additional, Luchetta, A., additional, Lunardon, F., additional, Manduchi, G., additional, Marconato, N., additional, Marcuzzi, D., additional, McCormack, O., additional, Milazzo, R., additional, Muraro, A., additional, Patton, T., additional, Pilan, N., additional, Recchia, M., additional, Rigoni-Garola, A., additional, Santoro, F., additional, Segalini, B., additional, Siragusa, M., additional, Spolaore, M., additional, Taliercio, C., additional, Toigo, V., additional, Zaccaria, P., additional, Zagorski, R., additional, Zanotto, L., additional, Zaupa, M., additional, Zuin, M., additional, and Serianni, G., additional

Published
2023
Full Text
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8. Lessons learned after three years of SPIDER operation and the first MITICA integrated tests

Author

Marcuzzi, D., primary, Toigo, V., additional, Boldrin, M., additional, Chitarin, G., additional, Dal Bello, S., additional, Grando, L., additional, Luchetta, A., additional, Pasqualotto, R., additional, Pavei, M., additional, Serianni, G., additional, Zanotto, L., additional, Agnello, R., additional, Agostinetti, P., additional, Agostini, M., additional, Aprile, D., additional, Barbisan, M., additional, Battistella, M., additional, Berton, G., additional, Bigi, M., additional, Brombin, M., additional, Candela, V., additional, Candeloro, V., additional, Canton, A., additional, Casagrande, R., additional, Cavallini, C., additional, Cavazzana, R., additional, Cordaro, L., additional, Cruz, N., additional, Dalla Palma, M., additional, Dan, M., additional, De Lorenzi, A., additional, Delogu, R., additional, De Muri, M., additional, De Nardi, M., additional, Denizeau, S., additional, Fadone, M., additional, Fellin, F., additional, Ferro, A., additional, Gaio, E., additional, Gasparrini, C., additional, Gnesotto, F., additional, Jain, P., additional, La Rosa, A., additional, Lopez-Bruna, D., additional, Lorenzini, R., additional, Maistrello, A., additional, Manduchi, G., additional, Manfrin, S., additional, Marconato, N., additional, Mario, I., additional, Martini, G., additional, Milazzo, R., additional, Patton, T., additional, Peruzzo, S., additional, Pilan, N., additional, Pimazzoni, A., additional, Poggi, C., additional, Pomaro, N., additional, Pouradier-Duteil, B., additional, Recchia, M., additional, Rigoni-Garola, A., additional, Rizzetto, D., additional, Rizzolo, A., additional, Santoro, F., additional, Sartori, E., additional, Segalini, B., additional, Shepherd, A., additional, Siragusa, M., additional, Sonato, P., additional, Sottocornola, A., additional, Spada, E., additional, Spagnolo, S., additional, Spolaore, M., additional, Taliercio, C., additional, Tinti, P., additional, Tomsič, P., additional, Trevisan, L., additional, Ugoletti, M., additional, Valente, M., additional, Valisa, M., additional, Veronese, F., additional, Vignando, M., additional, Zaccaria, P., additional, Zagorski, R., additional, Zaniol, B., additional, Zaupa, M., additional, Zuin, M., additional, Cavenago, M., additional, Boilson, D., additional, Rotti, C., additional, Decamps, H., additional, Geli, F., additional, Sharma, A., additional, Veltri, P., additional, Zacks, J., additional, Simon, M., additional, Paolucci, F., additional, Garbuglia, A., additional, Gutierrez, D., additional, Masiello, A., additional, Mico, G., additional, Labate, C., additional, Readman, P., additional, Bragulat, E., additional, Bailly-Maitre, L., additional, Gomez, G., additional, Kouzmenko, G., additional, Albajar, F., additional, Kashiwagi, M., additional, Tobari, H., additional, Kojima, A., additional, Murayama, M., additional, Hatakeyama, S., additional, Oshita, E., additional, Maejima, T., additional, Shibata, N., additional, Yamashita, Y., additional, Watanabe, K., additional, Singh, N.P., additional, Singh, M.J., additional, Dhola, H., additional, Fantz, U., additional, Heinemann, B., additional, Wimmer, C., additional, Wünderlich, D., additional, Tsumori, K., additional, Croci, G., additional, Gorini, G., additional, Muraro, A., additional, Rebai, M., additional, Tardocchi, M., additional, Giacomelli, L., additional, Rigamonti, D., additional, Taccogna, F., additional, Bruno, D., additional, Rutigliano, M., additional, Longo, S., additional, Deambrosis, S., additional, Miorin, E., additional, Montagner, F., additional, Tonti, A., additional, and Panin, F., additional

Published
2023
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11. The design of the ECH system of DTT

Author

Romano A., Baiocchi B., Balbinot L., Bin W., Bruschi A., Busi D., Bussolan A., De Nardi M., Fanale F., Fanelli P., Figini L., Gaio E., Garavaglia S., Giorgetti F., Granucci G., Moro A., Pepato A., and Platania P.

Subjects
Electron Cyclotron Resonant Heating, Divertor Tokamak Test Facility, DTT, ECRH
Published
2022

13. Integrating digital and field surveillance to complement efforts to manage epidemic diseases of livestock: African swine fever as a case study

Author

Ceschi P, Muñoz-Gómez, De Nardi M, Olga Munoz, Ilaria Capua, Paolotti D, Viltrop A, and Tizzani M

Subjects
African swine fever, Population level, business.industry, Infectious disease (medical specialty), Preparedness, Pandemic, Livestock, business, Environmental planning, Public attention, Field (computer science)
Abstract

The SARS-CoV-2 pandemic has unveiled the importance of stakeholders and ordinary citizens in managing infectious disease emergencies. Efficient management of infectious diseases requires a top-down approach which must be complemented with a bottom-up response to be effective. Here we investigate a novel approach to surveillance for transboundary animal diseases using African Swine fever as a model. We were able to collect data at a population level on information-seeking behavior and at a local level through a targeted questionnaire-based survey to relevant stakeholders such as farmers and veterinary authorities. Our study shows how information-seeking behavior and resulting public attention during an epidemic, can be addressed through novel data streams from digital platforms such as Wikipedia. We also bring evidence on how field surveys aimed at local workers (e.g. farmers) and public authorities remain a crucial tool to assess more in-depth preparedness and awareness among front-line actors. We conclude that they should be used in combination to maximize the outcome of surveillance and prevention activities for selected transboundary animal diseases.

Published
2021
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14. Status of the upgrade of RFX-mod2

Author

Marrelli L., Abate D., Agostinetti P., Agostini P., Aprile D., Auriemma F., Berton G., Bettini P., Bigi M., Boldrin M., Bolzonella T., Bonfiglio D., Bonotto M., Brombin M., Bustreo C., Candeloro V., Canton A., Cappello S., Carraro L., Cavallini C., Cavazzana R., Cordaro L., Dalla Palma M., Dal Bello S., Dan M., De Lorenzi A., De Masi G., De Nardi M., Di Giannatale G., Fadone M., Escande D.F., Fassina A., Ferro A., Ferron N., Fiorucci D., Franz P., Gaio E., Gambetta G., Gasparini F., Gnesotto F., Gobbin M., Grando L., Innocente P., Kryzhanovskyy A., Lorenzini R., Lunardon F., Maistrello A., Manduchi G., Manfrin S., Marchiori G., Marconato N., Martines E., Martini G., Martini S., Milazzo R., Momo B., Paccagnella R., Pavei M., Peruzzo S., Pigatto L., Pomaro N., Predebon I., Piovan R., Puiatti M.E., Recchia M., Rigoni A., Rizzetto D., Rizzolo A., Sattin F., Scarin P., Siragusa M., Sonato P., Spagnolo S., Spinicci L., Spizzo G., Spolaore M., Terranova D., Tinti P., Valisa M., Verando M., Vianello N., Vivenzi N., Voltolina D., Zanca P., Zaniol B., Zanotto L., and Zuin M.

Subjects
RFX-mod2 upgrade, RFX-mod2
Abstract

The RFX-mod Reversed Field Pinch device passive boundary is being improved: - Drastic reduction of resistivity of first shell surrounding the plasma; - Reduction of plasma-stabilizing conductor distance from b/a=1.11 to b/a=1.04. The RFX-mod core upgrades consist of: - Removal of Inconel vacuum vessel; - Modification of the stainless steel Support Structure to ensure Vacuum Tightness (VTSS); - Modification of the copper Passive Stabilizing Shell (PSS); - Installation of upgraded sensors inside the vacuum vessel. Initial main points of investigation in the new device are discussed.

Published
2021

15. SPIDER, the negative ion source prototype for ITER: first operations with caesium

Author

Serianni G., Sartori E., Agnello R., Agostini M., Barbisan M., Bigi M., Boldrin M., Brombin M., Candeloro V., Casagrande R., Dal Bello S., Dan M., Duteil B.P., Fadone M., Grando L., Jain P., Maistrello A., Mario I., Pasqualotto R., Pavei M., Pimazzoni A., Poggi C., Rizzolo A., Shepherd A., Ugoletti M., Veltri P., Zaniol B., Agostinetti P., Aprile D., Berton G., Cavallini C., Cavazzana R., Cavenago M., Chitarin G., Cristofaro S., Croci G., Cruz N., Dalla Palma M., Delogu R., De Muri M., De Nardi M., Denizeau S., Fellin F., Ferro A., Gaio E., Gasparrini C., Luchetta A., Lunardon F., Manduchi G., Marconato N., Marcuzzi D., McCormack O., Milazzo R., Muraro A., Patton T., Pilan N., Recchia M., Rigoni Garola A., Santoro F., Segalini B., Siragusa M., Spolaore M., Taliercio C., Zaccaria P., Zagorski R., Zanotto L., Zaupa M., Zuin M., and Toigo V.

Subjects
ITER, negative ion source prototype, caesium, SPIDER
Abstract

To reach fusion conditions and control the plasma configuration in ITER, the next step in tokamak fusion research, two neutral beam injectors (NBIs) will supply 17MW each, by neutralizing accelerated negative hydrogen or deuterium ions. The requirements of ITER NBIs (40A/1MeV D- ions for

Published
2021

16. RF Stray Currents in SPIDER and MITICA power circuits: model assessment and experimental results

Author

De Nardi M., Casagrande R., Maistrello A., Recchia M., Bigi M., and Zanotto L.

Subjects
MITICA, RF Stray Currents, SPIDER
Abstract

The ITER Neutral Beam Test Facility (NBTF) in Padova (Italy) hosts two different experiments: SPIDER, the prototype of the ion source of ITER Neutral Beam Injector (NBI) and MITICA, the prototype of the ITER NBI. The ion sources of SPIDER and MITICA are driven by Radio-Frequency (RF) power, for a total of 800kW at 1MHz. The RF power is delivered to the Inductively Coupled Plasma (ICP) drivers of the ion source by four tetrode oscillators through four RF circuits, each one consisting of a coaxial transmission line and a capacitive matching network. During SPIDER experimental campaign, the circulation of RF Stray Currents in the electric system has been pointed out. These currents hinder the correct operation of the system, thus preventing to achieve the full performances due to the excessive overheating of its components. To have a better comprehension of the issue, after an overall circuital investigation and the identification of a possible reclosing path for the RF Stray Currents, a simplified model of SPIDER electric system was developed, initially focusing on a single RF generator. The aim of the work presented in this paper is to upgrade this model, through a step-by-step procedure, by adding the other three RF oscillators, and their related RF circuits, in order to model a more complete version of the electric system of SPIDER. This upgraded model will allow increasing the knowledge of the issue and, in particular, understanding the impact of the four RF oscillators on the RF Stray Currents, also thanks to the support of the SPIDER's experimental results. After that, the task is trying to apply this model also to the MITICA ion source RF circuit in order to try predicting and, if possible, limiting the circulation of the RF Stray Currents during future MITICA operations.

Published
2021

17. Early operational experience and improvements of SPIDER ion source power supplies at beam energies exceeding 30 keV

Author

Bigi M., Agostini M., Casagrande R., Dan M., Jain P., Lunardon F., Maistrello A., De Nardi M., Recchia M., Santoro F., and Zanotto L.

Subjects
SPIDER, beam energies exceeding 30 keV, ion source power
Abstract

At the ITER Neutral Beam Test Facility in Padua (Italy), the ion source full scale prototype SPIDER has been in operation since June 2018. SPIDER is designed for an acceleration voltage of -100 kV, however early operation has taken place with a limit of -30 kV. As of March 2021, the limitation has been lifted and the experiment begun to explore the range of beam energies exceeding 30 keV. This has revealed a number of novel issues with the power supplies of ion source and extractor, mainly associated to grid breakdowns. Those power supplies include a set of high current single quadrant resonant converters, known as Source Support power supplies and a high voltage pulse step modulator feeding the extraction gap. The Source support power supplies perform a variety of functions, ranging from providing magnetic filter field current to polarising electrodes for minimization of the co-extracted electrons, from heating of the filaments to polarising the magnetic cores for protection from grid breakdowns. The Extraction Grid power supply extracts a negative ion and electron beam from the source, by applying a high voltage down to -12 kV dc to the gap between Plasma Grid and Extraction Grid. Grid breakdowns at beam energies exceeding 30 keV have shown the capability to upset the output measurements of the Source Support power supplies, limiting operation and reducing reliability of the whole system. The paper describes work undertaken firstly to identify the issues, found to belong to two distinct categories, general failures of all Source Support power supplies measurements and trips from the output voltage measurements of a well-defined subset of power supplies. Further investigation has associated the events to specific experimental conditions, pointing out weak points of the design and suggesting remedial actions. A number of modifications could be deployed quickly and tested in June 2021, before the stop to SPIDER operation for a planned major shutdown. The results of those tests are reported, along with the plan of future modifications for achieving immunity of the Source Support power supplies to the adverse effects of grid breakdowns at full acceleration voltage.

Published
2021

18. SPIDER, the Negative Ion Source Prototype for ITER: Overview of Operations and Cesium Injection

Author

Serianni, G., Sartori, E., Agnello, R., Agostini, M., Barbisan, M., Bigi, M., Boldrin, M., Brombin, M., Candeloro, V., Casagrande, R., Dal Bello, S., Dan, M., Duteil, B. P., Fadone, M., Grando, L., Jain, P., Maistrello, A., Mario, I., Pasqualotto, R., Pavei, M., Pimazzoni, A., Poggi, C., Rizzolo, A., Shepherd, A., Ugoletti, M., Veltri, P., Zaniol, B., Agostinetti, P., Aprile, D., Berton, G., Cavallini, C., Cavazzana, R., Cavenago, M., Chitarin, G., Cristofaro, S., Croci, G., Cruz, N., Dalla Palma, M., Delogu, R., De Muri, M., De Nardi, M., Denizeau, S., Fellin, F., Ferro, A., Gaio, E., Gasparrini, C., Luchetta, A., Lunardon, F., Manduchi, G., Marconato, N., Marcuzzi, D., McCormack, O., Milazzo, R., Muraro, A., Patton, T., Pilan, N., Recchia, M., Rigoni-Garola, A., Santoro, F., Segalini, B., Siragusa, M., Spolaore, M., Taliercio, C., Zaccaria, P., Zagorski, R., Zanotto, L., Zaupa, M., Zuin, M., and Toigo, V.

Abstract

An overview of the recent operations and the main results of cesium injection in the Source for the Production of Ions of Deuterium Extracted from Rf plasma (SPIDER) negative ion source are described in this contribution. In experiments without cesium injection, all SPIDER plants were tested to verify the basic expectations on the operational parameters (e.g., electron cooling effectiveness of magnetic filter field) and to determine its operational region. For beam properties, it was shown that the current density varies across the beam in the vertical direction. In preliminary cesium experiments, the expected increase of negative ion current and simultaneous decrease of co-extracted electrons were found, along with the influence of the control parameters (polarization of the plasma electrodes, magnetic filter field) on the SPIDER beam uniformity in the horizontal and vertical directions. It was shown that non-Gaussian tails can be identified in the angular distribution on the plane perpendicular to the beam propagation direction. Stray particles, nonhomogeneous beam and large divergence might result in unexpected heat and particle loads over ITER neutral beam injector (NBI) accelerator grids; it is the goal of SPIDER to assess and possibly to identify suitable methods for controlling these beam features. A major shutdown, planned for late 2021, to solve the issues identified during the operation and to carry out scheduled modifications, is outlined. Such improvements are expected to allow SPIDER to pursue the ITER requirements in terms of negative ion current, electron-to-ion ratio, and beam duration.

Published
2023
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20. Remembering Spaces of Work

Author

de Nardi, M., Orange, H., High, S., Koskinen-Koivisto, E., Pleasant, Emma, Strangleman, Tim, de Nardi, M., Orange, H., High, S., Koskinen-Koivisto, E., Pleasant, Emma, and Strangleman, Tim

Abstract

This chapter examines how the experience of work is embedded in multiple ways in place and places of work. Drawing on two research projects it looks in detail and the affect of work. It draws on and contributes to literature on the place of work, nostalgia and memory.

Published
2020

25. Modelling the species jump: towards assessing the risk of human infection from novel avian influenzas

Author

Hill, A A, Dewé, T, Kosmider, R, Von Dobschuetz, S, Munoz, O, Hanna, A, Fusaro, A, De Nardi, M, Howard, W, Stevens, K, Kelly, L, Havelaar, A, Stärk, K, Hill, A A, Dewé, T, Kosmider, R, Von Dobschuetz, S, Munoz, O, Hanna, A, Fusaro, A, De Nardi, M, Howard, W, Stevens, K, Kelly, L, Havelaar, A, and Stärk, K

Abstract

The scientific understanding of the driving factors behind zoonotic and pandemic influenzas is hampered by complex interactions between viruses, animal hosts and humans. This complexity makes identifying influenza viruses of high zoonotic or pandemic risk, before they emerge from animal populations, extremely difficult and uncertain. As a first step towards assessing zoonotic risk of influenza, we demonstrate a risk assessment framework to assess the relative likelihood of influenza A viruses, circulating in animal populations, making the species jump into humans. The intention is that such a risk assessment framework could assist decision-makers to compare multiple influenza viruses for zoonotic potential and hence to develop appropriate strain-specific control measures. It also provides a first step towards showing proof of principle for an eventual pandemic risk model. We show that the spatial and temporal epidemiology is as important in assessing the risk of an influenza A species jump as understanding the innate molecular capability of the virus. We also demonstrate data deficiencies that need to be addressed in order to consistently combine both epidemiological and molecular virology data into a risk assessment framework.

Published
2015

26. Modelling the species jump: towards assessing the risk of human infection from novel avian influenzas

Author

dIRAS RA-2, Risk Assessment, Hill, A A, Dewé, T, Kosmider, R, Von Dobschuetz, S, Munoz, O, Hanna, A, Fusaro, A, De Nardi, M, Howard, W, Stevens, K, Kelly, L, Havelaar, A, Stärk, K, dIRAS RA-2, Risk Assessment, Hill, A A, Dewé, T, Kosmider, R, Von Dobschuetz, S, Munoz, O, Hanna, A, Fusaro, A, De Nardi, M, Howard, W, Stevens, K, Kelly, L, Havelaar, A, and Stärk, K

Published
2015

30. Influenza at the animal-human interface: A review of the literature for virological evidence of human infection with swine or avian influenza viruses other than A(H5N1)

Author

Freidl, G.S. (Gudrun), Meijer, A. (Adam), Bruin, E. (Erwin) de, de Nardi, M. (Marco), Munoz, O. (Olga), Capua, I. (Ilaria), Breed, A.C., Harris, K. (Kate), Hill, A. (Andrew), Kosmider, R. (Rowena), Banks, J. (Jill), von Dobschuetz, S. (Sophie), Stärk, K.D.C. (Katharina D. C.), Wieland, B., Stevens, K., Werf, S. (Sylvie) van der, Enouf, V. (Vincent), van der Meulen, K. (Karen), Reeth, K. van, Dauphin, G. (Gwenaelle), Koopmans D.V.M., M.P.G. (Marion), Freidl, G.S. (Gudrun), Meijer, A. (Adam), Bruin, E. (Erwin) de, de Nardi, M. (Marco), Munoz, O. (Olga), Capua, I. (Ilaria), Breed, A.C., Harris, K. (Kate), Hill, A. (Andrew), Kosmider, R. (Rowena), Banks, J. (Jill), von Dobschuetz, S. (Sophie), Stärk, K.D.C. (Katharina D. C.), Wieland, B., Stevens, K., Werf, S. (Sylvie) van der, Enouf, V. (Vincent), van der Meulen, K. (Karen), Reeth, K. van, Dauphin, G. (Gwenaelle), and Koopmans D.V.M., M.P.G. (Marion)

Abstract

Factors that trigger human infection with animal influenza virus progressing into a pandemic are poorly understood. Within a project developing an evidence-based risk assessment framework for influenza viruses in animals, we conducted a review of the literature for evidence of human infection with animal influenza viruses by diagnostic methods used. The review covering Medline, Embase, SciSearch and CabAbstracts yielded 6,955 articles, of which we retained 89; for influenza A(H5N1) and A(H7N9), the official case counts of the World Health Organization were used. An additional 30 studies were included by scanning the reference lists. Here, we present the findings for confirmed infections with virological evidence. We found reports of 1,419 naturally infected human cases, of which 648 were associated with avian influenza virus (AIV) A(H5N1), 375 with other AIV subtypes, and 396 with swine influenza virus (SIV). Human cases naturally infected with AIV spanned haemagglutinin subtypes H5, H6, H7, H9 and H10. SIV cases were associated with endemic SIV of H1 and H3 subtype de

Published
2014

31. Influenza at the animal-human interface:A review of the literature for virological evidence of human infection with swine or avian influenza viruses other than A(H5N1)

Author

Freidl, G. S., Meijer, A., de Bruin, E., de Nardi, M., Munoz, O., Capua, I., Breed, A. C., Harris, K., Hill, A., Kosmider, R., Banks, J., von Dobschuetz, S., Stark, K., Wieland, B., Stevens, K., van der Werf, S., Enouf, V., van der Meulen, K., Van Reeth, K., Dauphin, G., Koopmans, M., Freidl, G. S., Meijer, A., de Bruin, E., de Nardi, M., Munoz, O., Capua, I., Breed, A. C., Harris, K., Hill, A., Kosmider, R., Banks, J., von Dobschuetz, S., Stark, K., Wieland, B., Stevens, K., van der Werf, S., Enouf, V., van der Meulen, K., Van Reeth, K., Dauphin, G., and Koopmans, M.

Abstract

Factors that trigger human infection with animal influenza virus progressing into a pandemic are poorly understood. Within a project developing an evidence-based risk assessment framework for influenza viruses in animals, we conducted a review of the literature for evidence of human infection with animal influenza viruses by diagnostic methods used. The review covering Medline, Embase, SciSearch and CabAbstracts yielded 6,955 articles, of which we retained 89; for influenza A(H5N1) and A(H7N9), the official case counts of the World Health Organization were used. An additional 30 studies were included by scanning the reference lists. Here, we present the findings for confirmed infections with virological evidence. We found reports of 1,419 naturally infected human cases, of which 648 were associated with avian influenza virus (AIV) A(H5N1), 375 with other AIV subtypes, and 396 with swine influenza virus (SIV). Human cases naturally infected with AIV spanned haemagglutinin subtypes H5, H6, H7, H9 and H10. SIV cases were associated with endemic SIV of H1 and H3 subtype descending from North American and Eurasian SIV lineages and various reassortants thereof. Direct exposure to birds or swine was the most likely source of infection for the cases with available information on exposure.

Published
2014

33. Rabies Vaccination: Higher Failure Rates in Imported Dogs than in those Vaccinated in Italy.

Author

Rota Nodari, E., Alonso, S., Mancin, M., De Nardi, M., Hudson‐Cooke, S., Veggiato, C., Cattoli, G., and De Benedictis, P.

Subjects
RABIES vaccines, RABIES in dogs, RABIES, DISEASE risk factors
Abstract

The current European Union ( EU) legislation decrees that pets entering the EU from a rabies-infected third country have to obtain a satisfactory virus-neutralizing antibody level, while those moving within the EU require only rabies vaccination as the risk of moving a rabid pet within the EU is considered negligible. A number of factors driving individual variations in dog vaccine response have been previously reported, including a high rate of vaccine failure in puppies, especially those subject to commercial transport. A total of 21 001 observations collected from dogs (2006-2012) vaccinated in compliance with the current EU regulations were statistically analysed to assess the effect of different risk factors related to rabies vaccine efficacy. Within this framework, we were able to compare the vaccination failure rate in a group of dogs entering the Italian border from EU and non- EU countries to those vaccinated in Italy prior to international travel. Our analysis identified that cross-breeds and two breed categories showed high vaccine success rates, while Beagles and Boxers were the least likely to show a successful response to vaccination (88.82% and 90.32%, respectively). Our analysis revealed diverse performances among the commercially available vaccines, in terms of serological peak windows, and marked differences according to geographical area. Of note, we found a higher vaccine failure rate in imported dogs (13.15%) than in those vaccinated in Italy (5.89%). Our findings suggest that the choice of vaccine may influence the likelihood of an animal achieving a protective serological level and that time from vaccination to sampling should be considered when interpreting serological results. A higher vaccine failure in imported compared to Italian dogs highlights the key role that border controls still have in assessing the full compliance of pet movements with EU legislation to minimize the risk of rabies being reintroduced into a disease-free area. [ABSTRACT FROM AUTHOR]

Published
2017
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35. Influenza surveillance in animals: what is our capacity to detect emerging influenza viruses with zoonotic potential?

Author

Stärk, Katharina D.C., Morgan, Dilys, VON DOBSCHUETZ, S., DE NARDI, M., HARRIS, K. A., MUNOZ, O., BREED, A. C., WIELAND, B., DAUPHIN, G., LUBROTH, J., and STÄRK, K. D. C.

Abstract

A survey of national animal influenza surveillance programmes was conducted to assess the current capacity to detect influenza viruses with zoonotic potential in animals (i.e. those influenza viruses that can be naturally transmitted between animals and humans) at regional and global levels. Information on 587 animal influenza surveillance system components was collected for 99 countries from Chief Veterinary Officers (CVOs) (n = 94) and published literature. Less than 1% (n = 4) of these components were specifically aimed at detecting influenza viruses with pandemic potential in animals (i.e. those influenza viruses that are capable of causing epidemic spread in human populations over large geographical regions or worldwide), which would have zoonotic potential as a prerequisite. Those countries that sought to detect influenza viruses with pandemic potential searched for such viruses exclusively in domestic pigs. This work shows the global need for increasing surveillance that targets potentially zoonotic influenza viruses in relevant animal species. [ABSTRACT FROM AUTHOR]

Published
2015
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38. Redox properties and cross-linking of the dithiol disulfide active-sites of mammalian protein disulfide-isomerase

Author

Hawkins, Hilary C., de Nardi, M., Freedman, Robert B., Hawkins, Hilary C., de Nardi, M., and Freedman, Robert B.

Abstract

1. The redox properties of the active-site dithiol/disulphide groups of PDI were determined by equilibrating the enzyme with an excess of GSH + GSSG, rapidly alkylating the dithiol form of the enzyme to inactivate it irreversibly, and determining the proportion of the disulphide form by measuring the residual activity under standard conditions. 2. The extent of reduction varied with the applied redox potential; to a first approximation, the data fitted a model in which all the enzyme dithiol/disulphide groups are independent and equivalent and the equilibrium constant between these sites and the GSH/GSSG redox couple is 42-mu-M at pH 7.5. 3. The standard redox potential for PDI active-site dithiol/disulphide couples was calculated from this result and found to be -0.11 V; hence PDI is a stronger oxidant and weaker reductant than GSH, nicotinamide cofactors, thioredoxin and dithiothreitol. 4. The redox equilibrium data for PDI with the GSH/GSSG redox couple showed sigmoidal deviations from linearity. The sigmoidicity could be modelled closely by assuming a Hill coefficient of 1.5. 5.This evidence of co-operative interactions between the four active sites in a PDI dimer was extended by studying the reaction between PDI and homobifunctional alkylating agents with various lengths between the reactive groups. A species whose electrophoretic mobility suggested it contained an intrachain cross-link was observed in all cases, whereas there was no evidence for cross-linking between the chains of the PDI homodimer. Most effective cross-linking was achieved with reagents containingfive or more methylene spacer groups, implying a minimum distance of 1.6 nm (16 angstrom) between the active-site reactive groups within the two thioredoxin-like domains of the PDI polypeptide.

Published
1991

41. SPIDER, the negative ion source prototype for ITER: overview of operations and caesium injection

Author

Serianni, G., Sartori, E., Agnello, R., Agostini, M., Barbisan, M., Bigi, M., Boldrin, M., Brombin, M., Candeloro, V., Casagrande, R., Dal Bello, S., Dan, M., Duteil, B. P., Fadone, M., Grando, L., Jain, P., Maistrello, A., Mario, I., Pasqualotto, R., Pavei, M., Pimazzoni, A., Poggi, C., Rizzolo, A., Shepherd, A., Ugoletti, M., Veltri, P., Zaniol, B., Agostinetti, P., Aprile, D., Berton, G., Cavallini, C., Cavazzana, R., Cavenago, M., Chitarin, G., Cristofaro, S., Croci, G., Cruz, N., Dalla Palma, M., Delogu, R., De Muri, M., De Nardi, M., Denizeau, S., Fellin, F., Ferro, A., Gaio, E., Gasparrini, C., Luchetta, A., Lunardon, F., Manduchi, G., Marconato, N., Marcuzzi, D., Mccormack, O., Milazzo, R., Muraro, A., Patton, T., Pilan, N., Recchia, M., Rigoni-Garola, A., Santoro, F., Segalini, B., Siragusa, M., Spolaore, M., Taliercio, C., Zaccaria, P., Zagorski, R., Zanotto, L., Zaupa, M., Zuin, M., and Toigo, V.

42. Influenza at the animal–human interface: a review of the literature for virological evidence of human infection with swine or avian influenza viruses other than A(H5N1)

Author

Freidl, G S, Meijer, A, De Bruin, E, De Nardi, M, Munoz, O, Capua, I, Breed, A C, Harris, K, Hill, A, Kosmider, R, Banks, J, Von Dobschuetz, S, Staerk, K D C, Wieland, B, Stevens, K, Van Der Werf, S, Enouf, V, Van Der Meulen, K, Van Reeth, K, Dauphin, G, Koopmans, M, FLURISK Consortium, AHVLA, Erasmus Medical Center, FAO - Rome, Ghent, IDS, The Netherlands, Inst Pasteur, and Ist Zooprofilatt

Subjects
viruses, animal diseases, virus diseases
Abstract

Factors that trigger human infection with animal influenza virus progressing into a pandemic are poorly understood. Within a project developing an evidence-based risk assessment framework for influenza viruses in animals, we conducted a review of the literature for evidence of human infection with animal influenza viruses by diagnostic methods used. The review covering Medline, Embase, SciSearch and CabAbstracts yielded 6,955 articles, of which we retained 89; for influenza A(H5N1) and A(H7N9), the official case counts of the World Health Organization were used. An additional 30 studies were included by scanning the reference lists. Here, we present the findings for confirmed infections with virological evidence. We found reports of 1,419 naturally infected human cases, of which 648 were associated with avian influenza virus (AIV) A(H5N1), 375 with other AIV subtypes, and 396 with swine influenza virus (SIV). Human cases naturally infected with AIV spanned haemagglutinin subtypes H5, H6, H7, H9 and H10. SIV cases were associated with endemic SIV of H1 and H3 subtype descending from North American and Eurasian SIV lineages and various reassortants thereof. Direct exposure to birds or swine was the most likely source of infection for the cases with available information on exposure.

43. Lessons learned after three years of SPIDER operation and the first MITICA integrated tests

Author

D. Marcuzzi, V. Toigo, M. Boldrin, G. Chitarin, S. Dal Bello, L. Grando, A. Luchetta, R. Pasqualotto, M. Pavei, G. Serianni, L. Zanotto, R. Agnello, P. Agostinetti, M. Agostini, D. Aprile, M. Barbisan, M. Battistella, G. Berton, M. Bigi, M. Brombin, V. Candela, V. Candeloro, A. Canton, R. Casagrande, C. Cavallini, R. Cavazzana, L. Cordaro, N. Cruz, M. Dalla Palma, M. Dan, A. De Lorenzi, R. Delogu, M. De Muri, M. De Nardi, S. Denizeau, M. Fadone, F. Fellin, A. Ferro, E. Gaio, C. Gasparrini, F. Gnesotto, P. Jain, A. La Rosa, D. Lopez-Bruna, R. Lorenzini, A. Maistrello, G. Manduchi, S. Manfrin, N. Marconato, I. Mario, G. Martini, R. Milazzo, T. Patton, S. Peruzzo, N. Pilan, A. Pimazzoni, C. Poggi, N. Pomaro, B. Pouradier-Duteil, M. Recchia, A. Rigoni-Garola, D. Rizzetto, A. Rizzolo, F. Santoro, E. Sartori, B. Segalini, A. Shepherd, M. Siragusa, P. Sonato, A. Sottocornola, E. Spada, S. Spagnolo, M. Spolaore, C. Taliercio, P. Tinti, P. Tomsič, L. Trevisan, M. Ugoletti, M. Valente, M. Valisa, F. Veronese, M. Vignando, P. Zaccaria, R. Zagorski, B. Zaniol, M. Zaupa, M. Zuin, M. Cavenago, D. Boilson, C. Rotti, H. Decamps, F. Geli, A. Sharma, P. Veltri, J. Zacks, M. Simon, F. Paolucci, A. Garbuglia, D. Gutierrez, A. Masiello, G. Mico, C. Labate, P. Readman, E. Bragulat, L. Bailly-Maitre, G. Gomez, G. Kouzmenko, F. Albajar, M. Kashiwagi, H. Tobari, A. Kojima, M. Murayama, S. Hatakeyama, E. Oshita, T. Maejima, N. Shibata, Y. Yamashita, K. Watanabe, N.P. Singh, M.J. Singh, H. Dhola, U. Fantz, B. Heinemann, C. Wimmer, D. Wünderlich, K. Tsumori, G. Croci, G. Gorini, A. Muraro, M. Rebai, M. Tardocchi, L. Giacomelli, D. Rigamonti, F. Taccogna, D. Bruno, M. Rutigliano, S. Longo, S. Deambrosis, E. Miorin, F. Montagner, A. Tonti, F. Panin, Marcuzzi, D, Toigo, V, Boldrin, M, Chitarin, G, Dal Bello, S, Grando, L, Luchetta, A, Pasqualotto, R, Pavei, M, Serianni, G, Zanotto, L, Agnello, R, Agostinetti, P, Agostini, M, Aprile, D, Barbisan, M, Battistella, M, Berton, G, Bigi, M, Brombin, M, Candela, V, Candeloro, V, Canton, A, Casagrande, R, Cavallini, C, Cavazzana, R, Cordaro, L, Cruz, N, Dalla Palma, M, Dan, M, De Lorenzi, A, Delogu, R, De Muri, M, De Nardi, M, Denizeau, S, Fadone, M, Fellin, F, Ferro, A, Gaio, E, Gasparrini, C, Gnesotto, F, Jain, P, La Rosa, A, Lopez-Bruna, D, Lorenzini, R, Maistrello, A, Manduchi, G, Manfrin, S, Marconato, N, Mario, I, Martini, G, Milazzo, R, Patton, T, Peruzzo, S, Pilan, N, Pimazzoni, A, Poggi, C, Pomaro, N, Pouradier-Duteil, B, Recchia, M, Rigoni-Garola, A, Rizzetto, D, Rizzolo, A, Santoro, F, Sartori, E, Segalini, B, Shepherd, A, Siragusa, M, Sonato, P, Sottocornola, A, Spada, E, Spagnolo, S, Spolaore, M, Taliercio, C, Tinti, P, Tomsic, P, Trevisan, L, Ugoletti, M, Valente, M, Valisa, M, Veronese, F, Vignando, M, Zaccaria, P, Zagorski, R, Zaniol, B, Zaupa, M, Zuin, M, Cavenago, M, Boilson, D, Rotti, C, Decamps, H, Geli, F, Sharma, A, Veltri, P, Zacks, J, Simon, M, Paolucci, F, Garbuglia, A, Gutierrez, D, Masiello, A, Mico, G, Labate, C, Readman, P, Bragulat, E, Bailly-Maitre, L, Gomez, G, Kouzmenko, G, Albajar, F, Kashiwagi, M, Tobari, H, Kojima, A, Murayama, M, Hatakeyama, S, Oshita, E, Maejima, T, Shibata, N, Yamashita, Y, Watanabe, K, Singh, N, Singh, M, Dhola, H, Fantz, U, Heinemann, B, Wimmer, C, Wunderlich, D, Tsumori, K, Croci, G, Gorini, G, Muraro, A, Rebai, M, Tardocchi, M, Giacomelli, L, Rigamonti, D, Taccogna, F, Bruno, D, Rutigliano, M, Longo, S, Deambrosis, S, Miorin, E, Montagner, F, Tonti, A, and Panin, F

Subjects
Accelerator Physics (physics.acc-ph), iter, Mechanical Engineering, FOS: Physical sciences, nbtf, neutral beam injector, mitica, Physics - Plasma Physics, Plasma Physics (physics.plasm-ph), Nuclear Energy and Engineering, Physics - Accelerator Physics, General Materials Science, spider, Civil and Structural Engineering
Abstract

ITER envisages the use of two heating neutral beam injectors plus an optional one as part of the auxiliary heating and current drive system, to reach the desired performances during its various phases of operation. The 16.5 MW expected neutral beam power per injector is several notches higher than worldwide existing facilities.In order to enable such development, a Neutral Beam Test Facility (NBTF) was established at Consorzio RFX, exploiting the synergy of two test beds, called SPIDER and MITICA. SPIDER is dedicated developing and char-acterizing large efficient negative ion sources at relevant parameters in ITER-like conditions: source and accel-erator located in the same vacuum where the beam propagates, immunity to electromagnetic interferences of multiple radio-frequency (RF) antennas, avoidance of RF-induced discharges on the outside of the source. Three years of experiments on SPIDER have addressed to the necessary design modifications to enable full perfor-mances. The source is presently under a long shut-down phase to incorporate learnings from the experimental campaign, in particular events/issues occurred during operation, which led to the identification of improvement opportunities/necessities (e.g. RF discharges, local burns, water leaks, other damages, configuration/design upgrades to maximize chances/margin to quest target parameters).Parallelly, developments on MITICA, the full-scale prototype of the ITER Neutral Beam Injector (NBI) featuring a 1 MV accelerator and ion neutralization, are underway including manufacturing of the beam source, accel-erator and the beam line components, while power supplies and auxiliary plants, already installed, are under final testing and commissioning.Integration, commissioning and tests of the 1 MV power supplies are essential for this first-of-kind system, unparalleled both in research and industry field. 1.2 MV dc insulating tests of high voltage components were successfully completed. The integrated test to confirm 1 MV output by combining invertor systems, DC gener-ators and transmission lines extracted errors/accidents in some components. To realize a concrete system for ITER, said events have been addressed and solutions for the repair and the improvement of the system were developed.Hence, NBTF is emerging as a necessary facility, due to the large gap with existing injectors, effectively dedicated to identify issues and find solutions to enable successful ITER NBI operations in a time bound fashion. The lessons learned during the implementation on NBTF and future perspectives are here discussed.

Published
2023
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44. Family and Government Insurance: Wage, Earnings, and Income Risks in the Netherlands and the U.S

Author

Marike Knoef, Mariacristina De Nardi, Raun van Ooijen, Giulio Fella, Gonzalo Paz-Pardo, Research programme EEF, De Nardi M, Fella G, Knoef M, Paz-Pardo G, and Van Ooijen R

Subjects
Economics and Econometrics, Self-insurance, Wage risk, media_common.quotation_subject, education, Wage, Social insurance, Transfer payment, Income distribution, 0502 economics and business, Economics, Progressive taxation, 050207 economics, health care economics and organizations, 050205 econometrics, media_common, Earnings, Life-cycle, 05 social sciences, Redistribution (cultural anthropology), Redistribution, Household income, Demographic economics, NA, Finance
Abstract

We document new facts about risk in male wages and earnings, household earnings, and pre- and post-tax income in the Netherlands and the United States. We find that, in both countries, earnings display important deviations from the typical assumptions of linearity and normality. Individual-level male wage and earnings risk is relatively high at the beginning and end of the working life, and for those in the lower and upper parts of the income distribution. Hours are the main driver of the negative skewness and, to a lesser extent, the high kurtosis of earnings changes. Even though we find no evidence of added-worker effects, the presence of spousal earnings reduces the variability of household income compared to that of male earnings. In the Netherlands, government transfers are a major source of insurance, substantially reducing the standard deviation, negative skewness, and kurtosis of income changes. In the U.S. the role of family insurance is much larger than in the Netherlands. Family and government insurance reduce, but do not eliminate non-linearities in household disposable income by age and previous earnings in either country.

Published
2019

45. ACUTE EFFECTS OF PARTIAL-BODY CRYOTHERAPY ON ISOMETRIC STRENGTH: MAXIMUM HANDGRIP STRENGTH EVALUATION

Author

R. Benis, Massimo De Nardi, Luisa Pizzigalli, Margherita Micheletti Cremasco, Federica Caffaro, De Nardi, M, Pizzigalli, L, Benis, R, Caffaro, F, and Micheletti Cremasco, M

Subjects
Acute effects, Adult, Male, medicine.medical_specialty, cryostimulation, medicine.medical_treatment, Physical Therapy, Sports Therapy and Rehabilitation, Cryotherapy, Isometric exercise, 03 medical and health sciences, 0302 clinical medicine, medicine, cryocabin, Humans, Orthopedics and Sports Medicine, muscle performance, Hand Strength, business.industry, hand dynamometer, 030229 sport sciences, General Medicine, Middle Aged, hand grip strenght, cryocabin, hand dynamometer, muscle performance, cryostimulation, hand grip strenght, Physical therapy, Muscle strength, Female, business, Single session, 030217 neurology & neurosurgery
Abstract

De Nardi, M, Pizzigalli, L, Benis, R, Caffaro, F, and Cremasco, MM. Acute effects of partial-body cryotherapy on isometric strength: maximum handgrip strength evaluation. J Strength Cond Res 31(12): 3497-3502, 2017-The aim of the study was to evaluate the influence of a single partial-body cryotherapy (PBC) session on the maximum handgrip strength (JAMAR Hydraulic Hand dynamometer). Two hundred healthy adults were randomized into a PBC group and a control group (50 men and 50 women in each group). After the initial handgrip strength test (T0), the experimental group performed a 150-second session of PBC (temperature range between -130 and -160° C), whereas the control group stayed in a thermo neutral room (22.0 ± 0.5° C). Immediately after, both groups performed another handgrip strength test (T1). Data underlined that both groups showed an increase in handgrip strength values, especially the experimental group (Control: T0 = 39.48 kg, T1 = 40.01 kg; PBC: T0 = 39.61 kg, T1 = 41.34 kg). The analysis also reported a statistical effect related to gender (F = 491.99, P ≤ 0.05), with women showing lower handgrip strength values compared with men (women = 30.43 kg, men = 52.27 kg). Findings provide the first evidence that a single session of PBC leads to the improvement of muscle strength in healthy people. The results of the study imply that PBC could be performed also before a training session or a sport competition, to increase hand isometric strength.

Published
2017

46. Nonlinear household earnings dynamics, self-insurance, and welfare

Author

Giulio Fella, Mariacristina De Nardi, Gonzalo Paz-Pardo, De Nardi M, Fella G, and Paz-Pardo G

Subjects
Consumption (economics), Earnings, Inequality, media_common.quotation_subject, education, 05 social sciences, Self-insurance, Social security, Shock (economics), Panel Study of Income Dynamics, 0502 economics and business, 8. Economic growth, Econometrics, Economics, NA, 050207 economics, General Economics, Econometrics and Finance, Welfare, health care economics and organizations, 050205 econometrics, media_common
Abstract

Earnings dynamics are much richer than typically assumed in macro models with heterogeneous agents. This holds for individual-pre-tax and household-post-tax earnings and across administrative (Social Security Administration) and survey (Panel Study of Income Dynamics) data. We study the implications of two processes for household, post-tax earnings in a standard life-cycle model: a canonical earnings process (that includes a persistent and a transitory shock) and a rich earnings dynamics process (that allows for age-dependence of moments, non-normality, and nonlinearity in previous earnings and age). Allowing for richer earnings dynamics implies a substantially better fit of the evolution of cross-sectional consumption inequality over the life cycle and of the individual-level degree of consumption insurance against persistent earnings shocks. Richer earnings dynamics also imply lower welfare costs of earnings risk, but, as the canonical earnings process, do not generate enough concentration at the upper tail of the wealth distribution.

47. Effects of cryo-facial mask on running performance in amateur middle-distance runners.

Author

De Nardi M, Filipas L, Di Gennaro S, Allemano S, Gallo G, Meloni A, Della Guardia L, Luzi L, La Torre A, and Codella R

Subjects
Humans, Male, Adult, Cross-Over Studies, Skin Temperature, Cold Temperature, Face, Cryotherapy methods, Cryotherapy instrumentation, Physical Endurance, Exercise Test, Running physiology, Heart Rate, Masks, Athletic Performance physiology
Abstract

The excess heat accumulated during exercise can lead to stress-induced fatigue, possibly impairing athletic performance. Various precooling techniques have been applied to enhance thermal comfort, reduce perception of effort, and improve endurance. In this randomized crossover study, twelve male amateur middle-distance runners (age: 33.69 ± 5.9 years; body mass: 71.9 ± 4.4 kg; height: 178.4 ± 5.6 cm; V˙O 2 peak: 63.3 ± 5.6 mL min -1 ·kg -1 ) wore a facial cooling mask before a time-to-exhaustion (TTE) test on a treadmill, under cryostimulation or control conditions. The running performance comprised also two constant load trials, one conducted before and another after wearing the mask, both performed at the velocity of the first ventilatory threshold. Under cryostimulation condition, the TTE was 13 % higher than the control condition (p = 0.0049; d = -0.19) with a significant main effect of time for both ratings of perceived exertion (F 1, 22  = 50.10; p < 0.0001; η 2 p = 0.69) and heart rate (F 1, 22  = 31.53; p < 0.0001; η 2 p = 0.59). A significant interaction "condition × time" was found for facial skin temperature (F 2, 44  = 36.93; p < 0.0001; η 2 p = 0.63) and for heart rate during the constant load trial after wearing the mask (F 1, 22  = 5.90; p = 0.0238; η 2 p = 0.21). The localized cryostimulation provided by the mask lowered the skin temperature on the face, potentially mitigating the negative effects of heat stress during running. Incorporating the cryo-facial mask as part of a pre-exercise routine for runners may offer a practical and convenient method to optimize performance and enhance overall training outcomes., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The mask was purchased on a voluntary basis; the manufacturer was utterly unaware of this proof-of-concept study., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2024
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48. Partial-body cryostimulation procured performance and perceptual improvements in amateur middle-distance runners.

Author

De Nardi M, Filipas L, Facheris C, Righetti S, Tengattini M, Faelli E, Bisio A, Gallo G, La Torre A, Ruggeri P, and Codella R

Subjects
Adult, Humans, Middle Aged, Athletes, Heart Rate physiology, Oxygen Consumption physiology, Time Factors, Cross-Over Studies, Cancer Vaccines, Running physiology
Abstract

The purpose of this study was to investigate the effects of partial-body cryostimulation on middle-distance runners before two 3000-m tests at the speed of the first and second ventilatory threshold, and before a time to exhaustion test at 110% of the maximal aerobic speed. Twelve amateur runners (age: 46 ± 9 years; VO2max: 51.7 ± 4.9 ml·kg-1·min-1) completed six running testing sessions in a randomized counterbalanced cross-over fashion: three of them were preceded by a partial-body cryostimulation and the other three by a control condition. The testing sessions consisted of: 1) a 3000-m continuous running test at the speed of the first ventilatory threshold; 2) a 3000-m continuous running test at the speed of the second ventilatory threshold; 3) a time to exhaustion test at 110% of the maximal aerobic speed. Heart rate, ratings of perceived exertion and visual analogue scale relative to muscle pain were recorded throughout the tests. Total quality recovery was evaluated 24-48 h after the end of each test. Distance to exhaustion was higher after partial-body cryostimulation than control condition (p = 0.018; partial-body cryostimulation: 988 ± 332 m, control: 893 ± 311 m). There were differences in the ratings of perceived exertion during each split of the 3000-m continuous running test at the speed of the second ventilatory threshold (p = 0.001). Partial-body cryostimulation can be positively considered to enhance middle-distance running performance and reduce perception of effort in amateur runners., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 De Nardi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Published
2023
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49. Thermal responses induced by nitrogen and forced convection based partial-body cryostimulation.

Author

De Nardi M, Allemano S, Bisio A, Faelli E, La Torre A, Ruggeri P, and Codella R

Subjects
Humans, Convection, Cold Temperature
Abstract

Partial Body Cryostimulation (PBC) involves a very cold air flow directed to the body of subjects with minimal clothing. PBC is performed in a rapid timeframe, inside an on-purposed designed cryo-cabin. Recently, cryo-cabins have been built with different energy systems, however a validation study on relative thermal responses is missing. This study was aimed at comparing thermal responses following a PBC in an electrically powered cryo-cabin based on forced convection or into a standard nitrogen-fueled cryo-cabin. In a randomized crossover fashion, thirty-six subjects (F=20; M=16) underwent both cryo-exposures lasting 150 s each. Thermal responses were assessed before and immediately after completing each PBC session. Mixed model analysis of variance revealed a significantly colder temperature after electric PBC in all the body regions (except for the thighs) with respect to a standard nitrogen based PBC (F: 16.4 ± 1.4 vs 18 ± 5.8 °C; M: 16.4 ± 1.7 vs 20.9 ± 4 °C). Moreover, a significant lower thermal discomfort was perceived at the end of electric PBC as compared to that one felt following standard PBC. For the first time, the safety and thermo-effectiveness of an electric cryo-cabin based on forced convection was ensured. This methodology can be viable for practitioners of PBC and clinicians., Competing Interests: Declaration of competing interest None, (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Published
2023
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50. Epidemic intelligence data of Crimean-Congo haemorrhagic fever, European Region, 2012 to 2022: a new opportunity for risk mapping of neglected diseases.

Author

Fanelli A, Schnitzler JC, De Nardi M, Donachie A, Capua I, Lanave G, Buonavoglia D, Caceres-Soto P, and Tizzani P

Subjects
Humans, Neglected Diseases epidemiology, Bayes Theorem, Hemorrhagic Fever, Crimean diagnosis, Hemorrhagic Fever, Crimean epidemiology, Hemorrhagic Fever Virus, Crimean-Congo, Epidemics
Abstract

BackgroundThe Epidemic Intelligence from Open Sources (EIOS) system, jointly developed by the World Health Organisation (WHO), the Joint Research Centre (JRC) of the European Commission and various partners, is a web-based platform that facilitate the monitoring of information on public health threats in near real-time from thousands of online sources.AimsTo assess the capacity of the EIOS system to strengthen data collection for neglected diseases of public health importance, and to evaluate the use of EIOS data for improving the understanding of the geographic extents of diseases and their level of risk.MethodsA Bayesian additive regression trees (BART) model was implemented to map the risk of Crimean-Congo haemorrhagic fever (CCHF) occurrence in 52 countries and territories within the European Region between January 2012 and March 2022 using data on CCHF occurrence retrieved from the EIOS system.ResultsThe model found a positive association between all temperature-related variables and the probability of CCHF occurrence, with an increased risk in warmer and drier areas. The highest risk of CCHF was found in the Mediterranean basin and in areas bordering the Black Sea. There was a general decreasing risk trend from south to north across the entire European Region.ConclusionThe study highlights that the information gathered by public health intelligence can be used to build a disease risk map. Internet-based sources could aid in the assessment of new or changing risks and planning effective actions in target areas.

Published
2023
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