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1. Numerical approximations of McKean Anticipative Backward Stochastic Differential Equations arising in Initial Margin requirements

Author

Agarwal, A., De Marco, S., Gobet, E., Lopez-Salas, J. G., Noubiagain, F., and Zhou, A.

Subjects
Quantitative Finance - Pricing of Securities, Mathematics - Optimization and Control, Mathematics - Probability
Abstract

We introduce a new class of anticipative backward stochastic differential equations with a dependence of McKean type on the law of the solution, that we name MKABSDE. We provide existence and uniqueness results in a general framework with relatively general regularity assumptions on the coefficients. We show how such stochastic equations arise within the modern paradigm of derivative pricing where a central counterparty (CCP) requires the members to deposit variation and initial margins to cover their exposure. In the case when the initial margin is proportional to the Conditional Value-at-Risk (CVaR) of the contract price, we apply our general result to define the price as a solution of a MKABSDE. We provide several linear and non-linear simpler approximations, which we solve using different numerical (deterministic and Monte-Carlo) methods.

Published
2024
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2. Seismic Analyses of Menta Embankment Dam: Formulation and Synthesis of Results

Author

Russo, G., Cecconi, M., Vecchietti, A., Pane, V., Fiorino, A., De Marco, S., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Bolzon, Gabriella, editor, Sterpi, Donatella, editor, Mazzà, Guido, editor, and Frigerio, Antonella, editor

Published
2021
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3. Impairment of Renal and Hematopoietic Stem/Progenitor Cell Compartments in Frailty Syndrome: Link with Oxidative Stress, Plasma Cytokine Profiles and Nuclear DNA Damage

Author

Bombelli, S, Grasselli, C, Mazzola, P, Veronesi, V, Morabito, I, Zucchini, N, Scollo, C, Blanco, S, De Marco, S, Torsello, B, Vitarelli, F, Antolini, L, Bianchi, C, Leoni, V, Bellelli, G, Perego, R, Bombelli, Silvia, Grasselli, Chiara, Mazzola, Paolo, Veronesi, Valentina, Morabito, Ivana, Zucchini, Nicola, Scollo, Chiara M, Blanco, Salvatore I, De Marco, Sofia, Torsello, Barbara, Vitarelli, Federica, Antolini, Laura, Bianchi, Cristina, Leoni, Valerio, Bellelli, Giuseppe, Perego, Roberto A, Bombelli, S, Grasselli, C, Mazzola, P, Veronesi, V, Morabito, I, Zucchini, N, Scollo, C, Blanco, S, De Marco, S, Torsello, B, Vitarelli, F, Antolini, L, Bianchi, C, Leoni, V, Bellelli, G, Perego, R, Bombelli, Silvia, Grasselli, Chiara, Mazzola, Paolo, Veronesi, Valentina, Morabito, Ivana, Zucchini, Nicola, Scollo, Chiara M, Blanco, Salvatore I, De Marco, Sofia, Torsello, Barbara, Vitarelli, Federica, Antolini, Laura, Bianchi, Cristina, Leoni, Valerio, Bellelli, Giuseppe, and Perego, Roberto A

Abstract

Frailty is an age-related syndrome that drives multiple physiological system impairments in some older adults, and its pathophysiological mechanisms remain unclear. We evaluated whether frailty-related biological processes could impair stem cell compartments, specifically the renal stem compartment, given that kidney dysfunctions are frequent in frailty. A well-characterized in vitro nephrosphere model of human adult renal stem/progenitor cells has been instrumental to and was appropriate for verifying this hypothesis in our current research. Evaluating the effects of plasma from older individuals with frailty (frail plasma) on allogeneic renal stem/progenitor cells, we showed significant functional impairment and nuclear DNA damage in the treated cells of the renal stem compartment. The analysis of the frail plasma revealed mitochondrial functional impairment associated with the activation of oxidative stress and a unique inflammatory mediator profile in frail individuals. In addition, the plasma of frail subjects also contained the highest percentage of DNA-damaged autologous circulating hematopoietic progenitor/stem cells. The integration of both molecular and functional data obtained allowed us to discern patterns associated with frailty status, irrespective of the comorbidities present in the frail individuals. The data obtained converged toward biological conditions that in frailty caused renal and hematopoietic impairment of stem cells, highlighting the possibility of concomitant exhaustion of several stem compartments.

Published
2024

5. Biological conditions related to friality and their effects on adult renal stem cells cultured as nephrospheres

Author

Grasselli, C, Bombelli, S, Tropeano, C, De Marco, S, Torsello, B, Bianchi, C, Antolini, L, Mazzola, P, Leoni, V, Bellelli, G, Perego, R, Grasselli C, Bombelli S, Tropeano C, De Marco S, Torsello B, Bianchi C, Antolini L, Mazzola P, Leoni V, Bellelli G, Perego RA, Grasselli, C, Bombelli, S, Tropeano, C, De Marco, S, Torsello, B, Bianchi, C, Antolini, L, Mazzola, P, Leoni, V, Bellelli, G, Perego, R, Grasselli C, Bombelli S, Tropeano C, De Marco S, Torsello B, Bianchi C, Antolini L, Mazzola P, Leoni V, Bellelli G, and Perego RA

Published
2022

6. DNA damage and reactive oxygen species as promising biological indicators of friality

Author

Bombelli, S, Grasselli, C, Tropeano, C, De Marco, S, Torsello, B, Bianchi, C, Antolini, L, Mazzola, P, Leoni, V, Bellelli, G, Perego, R, Bombelli S, Grasselli C, Tropeano C, De Marco S, Torsello B, Bianchi C, Antolini L, Mazzola P, Leoni V, Bellelli G, Perego RA, Bombelli, S, Grasselli, C, Tropeano, C, De Marco, S, Torsello, B, Bianchi, C, Antolini, L, Mazzola, P, Leoni, V, Bellelli, G, Perego, R, Bombelli S, Grasselli C, Tropeano C, De Marco S, Torsello B, Bianchi C, Antolini L, Mazzola P, Leoni V, Bellelli G, and Perego RA

Published
2022

7. Hematopoietic Stem Cell (HSC)-Independent Progenitors Are Susceptible to Mll-Af9-Induced Leukemic Transformation

Author

Barone, C, Orsenigo, R, Cazzola, A, D'Errico, E, Patelli, A, Quattrini, G, Vergani, B, Bombelli, S, De Marco, S, D'Orlando, C, Bianchi, C, Leone, B, Meneveri, R, Biondi, A, Cazzaniga, G, Rabbitts, T, Brunelli, S, Azzoni, E, Barone, C, Orsenigo, R, Cazzola, A, D'Errico, E, Patelli, A, Quattrini, G, Vergani, B, Bombelli, S, De Marco, S, D'Orlando, C, Bianchi, C, Leone, B, Meneveri, R, Biondi, A, Cazzaniga, G, Rabbitts, T, Brunelli, S, and Azzoni, E

Abstract

Infant acute myeloid leukemia (AML) is a heterogeneous disease, genetically distinct from its adult counterpart. Chromosomal translocations involving the KMT2A gene (MLL) are especially common in affected infants of less than 1 year of age, and are associated with a dismal prognosis. While these rearrangements are likely to arise in utero, the cell of origin has not been conclusively identified. This knowledge could lead to a better understanding of the biology of the disease and support the identification of new therapeutic vulnerabilities. Over the last few years, important progress in understanding the dynamics of fetal hematopoiesis has been made. Several reports have highlighted how hematopoietic stem cells (HSC) provide little contribution to fetal hematopoiesis, which is instead largely sustained by HSC-independent progenitors. Here, we used conditional Cre-Lox transgenic mouse models to engineer the Mll-Af9 translocation in defined subsets of embryonic hematopoietic progenitors. We show that embryonic hematopoiesis is generally permissive for Mll-Af9-induced leukemic transformation. Surprisingly, the selective introduction of Mll-Af9 in HSC-independent progenitors generated a transplantable myeloid leukemia, whereas it did not when introduced in embryonic HSC-derived cells. Ex vivo engineering of the Mll-Af9 rearrangement in HSC-independent progenitors using a CRISPR/Cas9-based approach resulted in the activation of an aberrant myeloid-biased self-renewal program. Overall, our results demonstrate that HSC-independent hematopoietic progenitors represent a permissive environment for Mll-Af9-induced leukemic transformation, and can likely act as cells of origin of infant AML.

Published
2023

8. High glucose induces an activated state of partial epithelial-mesenchymal transition in human primary tubular cell cultures

Author

Torsello, B, De Marco, S, Bombelli, S, Cifola, I, Morabito, I, Invernizzi, L, Meregalli, C, Zucchini, N, Strada, G, Perego, R, Bianchi, C, Torsello, Barbara, De Marco, Sofia, Bombelli, Silvia, Cifola, Ingrid, Morabito, Ivana, Invernizzi, Lara, Meregalli, Chiara, Zucchini, Nicola, Strada, Guido, Perego, Roberto A, Bianchi, Cristina, Torsello, B, De Marco, S, Bombelli, S, Cifola, I, Morabito, I, Invernizzi, L, Meregalli, C, Zucchini, N, Strada, G, Perego, R, Bianchi, C, Torsello, Barbara, De Marco, Sofia, Bombelli, Silvia, Cifola, Ingrid, Morabito, Ivana, Invernizzi, Lara, Meregalli, Chiara, Zucchini, Nicola, Strada, Guido, Perego, Roberto A, and Bianchi, Cristina

Abstract

Tubulointerstitial fibrosis is observed in diabetic nephropathy. It is still debated whether tubular cells, undergoing epithelial-mesenchymal transition (EMT) in high glucose (HG) conditions, may contribute to interstitial fibrosis development. In this study, we investigated the phenotypic and molecular EMT-like changes and the alteration of inflammatory and fibrogenic secretome induced by HG in human primary tubular cell cultures. Taking advantage of this in vitro cell model composed of proximal and distal tubular cells, we showed that HG-treated tubular cells acquired a fibroblast-like morphology with increased cytoplasmic stress fibers, maintaining the expression of the epithelial markers specific of proximal and distal tubular cells. HG increased Snail1, miRNA210 and Vimentin mesenchymal markers, decreased N-cadherin expression and migration ability of primary tubular cells, while E-cadherin expression and focal adhesion distribution were not affected. Furthermore, HG treatment of tubular cells altered the inflammatory cytokine secretion creating a secretome able to enhance the proliferation and migration of fibroblasts. Our findings show that HG promotes an activated state of partial EMT in human tubular primary cells and induces a pro-inflammatory and pro-fibrogenic microenvironment, supporting the active role of tubular cells in diabetic nephropathy onset.

Published
2023

10. Weak approximations and VIX option price expansions in forward variance curve models.

Author

Bourgey, F., De Marco, S., and Gobet, E.

Subjects
*PRICES, *STOCK index futures, *OPTIONS (Finance), *FUTURES
Abstract

We provide explicit approximation formulas for VIX futures and options in forward variance models, with particular emphasis on the family of so-called Bergomi models: the one-factor Bergomi model, the rough Bergomi model, and an enhanced version of the rough model that can generate realistic positive skew for VIX smiles–introduced simultaneously by De Marco and Guyon at the Bachelier World Congress 2018, that we refer to as 'mixed rough Bergomi model'. Following the methodology set up in previous works of Gobet and Miri on asymptotic approximations for integrated diffusion processes, we derive weak approximations for the law of the VIX, leading to option price approximations under the form of explicit combinations of Black–Scholes prices and greeks. As new contributions, we cope with the fractional integration kernel appearing in rough models, and treat the case of non-smooth payoffs, so as to encompass VIX futures, call, and put options. We stress that our approach does not rely on small maturity asymptotics, and can therefore be applied to any VIX option maturity. Our results are illustrated by several numerical experiments over a wide range of model parameter configurations, and by calibration tests to VIX market data. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Molecular characterization of nephrosphere-derived PKH/CD133+/CD24- stem-like cells evidenced possible new marker for renal stem cells in situ identification

Author

Bombelli, S, Eriani, S, Grasselli, C, Bolognesi, M, Rossetti, G, Ranzani, V, Torsello, B, De Marco, S, Bianchi, C, Pagani, M, Cattoretti, G, Perego, R, Bombelli S, Eriani S, Grasselli C, Bolognesi M, Rossetti G, Ranzani V, Torsello B, De Marco S, Bianchi C, Pagani M, Cattoretti G, Perego RA, Bombelli, S, Eriani, S, Grasselli, C, Bolognesi, M, Rossetti, G, Ranzani, V, Torsello, B, De Marco, S, Bianchi, C, Pagani, M, Cattoretti, G, Perego, R, Bombelli S, Eriani S, Grasselli C, Bolognesi M, Rossetti G, Ranzani V, Torsello B, De Marco S, Bianchi C, Pagani M, Cattoretti G, and Perego RA

Published
2021

12. Clear cell renal cell carcinoma invasion is modulated by TGFb/Arg interaction

Author

De Marco, S, Torsello, B, Bombelli, S, Grasselli, C, Zucchini, N, Strada, G, Perego, R, Bianchi, C, De Marco S, Torsello B, Bombelli S, Grasselli C, Zucchini N, Strada G, Perego RA, Bianchi C, De Marco, S, Torsello, B, Bombelli, S, Grasselli, C, Zucchini, N, Strada, G, Perego, R, Bianchi, C, De Marco S, Torsello B, Bombelli S, Grasselli C, Zucchini N, Strada G, Perego RA, and Bianchi C

Published
2021

16. The relationship between cardiac injury, inflammation and coagulation in predicting COVID-19 outcome

Author

Mengozzi, A., Georgiopoulos, G., Falcone, M., Tiseo, G., Pugliese, N. R., Dimopoulos, M. A., Ghiadoni, L., Barbieri, G., Forfori, F., Carrozzi, L., Santini, M., Monzani, F., De Marco, S., Menichetti, F., Virdis, A., Masi, S., Sabrina, A. D. I., Martina, B., Matteo, B., Elia, N., Stefano, S., Rachele, A., Valeria, C., Simone, P., Rubia, B., Pietro, B., Giulia, B., Forfori, Francesco, Alessandra, D. R., Fabio, G., Paolo, M., Marco, M., Chiara, P., Alessandro, C., Francesco, C., Naria, P., Luciano, C., Chiara, S., Valentina, G., Uliana, M., Francesca, R., Giovanna, F., and Maria, S.

Subjects
Male, Hemodynamics, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Prognostic markers, 0302 clinical medicine, Clinical endpoint, Hospital Mortality, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, education.field_of_study, Multidisciplinary, Confounding, Low-Molecular-Weight, Blood Coagulation Disorders, Middle Aged, Prognosis, C-Reactive Protein, Cardiology, Medicine, Female, Risk, medicine.medical_specialty, Heart Diseases, medicine.drug_class, Science, Population, Low molecular weight heparin, Predictive markers, COVID-19, Fibrin Fibrinogen Degradation Products, Heparin, Low-Molecular-Weight, Humans, Inflammation, SARS-CoV-2, Troponin T, Article, 03 medical and health sciences, Internal medicine, medicine, Coagulopathy, education, Heparin, business.industry, medicine.disease, Observational study, business
Abstract

Introduction: High sensitivity troponin T (hsTnT) is a strong predictor of adverse outcome during SARS-CoV-2 infection. However, its determinants remain partially unknown. We aimed to assess the relationship between severity of inflammatory response/coagulation abnormalities and hsTnT in Coronavirus Disease 2019 (COVID-19). We then explored the relevance of these pathways in defining mortality and complications risk and the potential effects of the treatments to attenuate such risk.Methods: In this single-center, prospective, observational study we enrolled 266 consecutive patients hospitalized for SARS-CoV-2 pneumonia. Primary endpoint was in-hospital COVID-19 mortality. Results: hsTnT, even after adjustment for confounders, was associated with mortality. D-dimer and CRP presented stronger associations with hsTnT than PaO2. Changes of hsTnT, D-dimer and CRP were related but only D-dimer was associated with mortality. Moreover, low molecular weight heparin showed attenuation of the mortality in the whole population, particularly in subjects with higher hsTnT.Conclusions: D-dimer possessed a strong relationship with hsTnT and mortality. Anticoagulation treatment showed greater benefits with regard to mortality. These findings suggest a major role of SARS-CoV-2 coagulopathy in hsTnT elevation and its related mortality in COVID-19. A better understanding of the mechanisms related to COVID-19 might pave the way to therapy tailoring in these high-risk individuals.

Published
2021

17. Biological conditions related to frailty influence the behavior of renal stem/progenitor cells grown as nephrospheres

Author

Bombelli, S, Grasselli, C, Veronesi, V, Tropeano, C, Dominici, G, De Marco, S, Torsello, B, Bianchi, C, Antolini, L, Mazzola, P, Bellelli, G, Leoni, V, Perego, R, S. Bombelli, C. Grasselli, V. Veronesi, C. Tropeano, G. Dominici, S. De Marco, B. Torsello, C. Bianchi, L. Antolini, P. Mazzola, G. Bellelli, V. Leoni, R. A. Perego, Bombelli, S, Grasselli, C, Veronesi, V, Tropeano, C, Dominici, G, De Marco, S, Torsello, B, Bianchi, C, Antolini, L, Mazzola, P, Bellelli, G, Leoni, V, Perego, R, S. Bombelli, C. Grasselli, V. Veronesi, C. Tropeano, G. Dominici, S. De Marco, B. Torsello, C. Bianchi, L. Antolini, P. Mazzola, G. Bellelli, V. Leoni, and R. A. Perego

Published
2022

18. PPAR-alpha and PPAR-gamma involvement in grade-dependent lipid storage of clear cell renal cell carcinoma cells

Author

De Marco, S, Torsello, B, Morabito, I, Grasselli, C, Bombelli, S, Cifola, I, Zucchini, N, Perego, R, Bianchi, C, S. De Marco, B. Torsello, I. Morabito, C. Grasselli, S. Bombelli, I. Cifola, N. Zucchini, R. A. Perego, C. Bianchi, De Marco, S, Torsello, B, Morabito, I, Grasselli, C, Bombelli, S, Cifola, I, Zucchini, N, Perego, R, Bianchi, C, S. De Marco, B. Torsello, I. Morabito, C. Grasselli, S. Bombelli, I. Cifola, N. Zucchini, R. A. Perego, and C. Bianchi

Published
2022

19. PKHhigh/CD133+/CD24- Renal Stem-Like Cells Isolated from Human Nephrospheres Exhibit In Vitro Multipotency

Author

Bombelli, S, Meregalli, C, Grasselli, C, Bolognesi, M, Bruno, A, Eriani, S, Torsello, B, De Marco, S, Bernasconi, D, Zucchini, N, Mazzola, P, Bianchi, C, Grasso, M, Albini, A, Cattoretti, G, Perego, R, Bombelli S., Meregalli C., Grasselli C., Bolognesi M. M., Bruno A., Eriani S., Torsello B., De Marco S., Bernasconi D. P., Zucchini N., Mazzola P., Bianchi C., Grasso M., Albini A., Cattoretti G., Perego R. A., Bombelli, S, Meregalli, C, Grasselli, C, Bolognesi, M, Bruno, A, Eriani, S, Torsello, B, De Marco, S, Bernasconi, D, Zucchini, N, Mazzola, P, Bianchi, C, Grasso, M, Albini, A, Cattoretti, G, Perego, R, Bombelli S., Meregalli C., Grasselli C., Bolognesi M. M., Bruno A., Eriani S., Torsello B., De Marco S., Bernasconi D. P., Zucchini N., Mazzola P., Bianchi C., Grasso M., Albini A., Cattoretti G., and Perego R. A.

Abstract

The mechanism upon which human kidneys undergo regeneration is debated, though different lineage-tracing mouse models have tried to explain the cellular types and the mechanisms involved. Different sources of human renal progenitors have been proposed, but it is difficult to argue whether these populations have the same capacities that have been described in mice. Using the nephrosphere (NS) model, we isolated the quiescent population of adult human renal stem-like PKHhigh/CD133+/CD24- cells (RSC). The aim of this study was to deepen the RSC in vitro multipotency capacity. RSC, not expressing endothelial markers, generated secondary nephrospheres containing CD31+/vWf+ cells and cytokeratin positive cells, indicating the coexistence of endothelial and epithelial commitment. RSC cultured on decellularized human renal scaffolds generated endothelial structures together with the proximal and distal tubular structures. CD31+ endothelial committed progenitors sorted from nephrospheres generated spheroids with endothelial-like sprouts in Matrigel. We also demonstrated the double commitment toward endothelial and epithelial lineages of single RSC. The ability of the plastic RSC population to recapitulate the development of tubular epithelial and endothelial renal lineages makes these cells a good tool for the creation of organoids with translational relevance for studying the parenchymal and endothelial cell interactions and developing new therapeutic strategies.

Published
2020

21. The relationship between cardiac injury, inflammation and coagulation in predicting COVID-19 outcome

Author

Mengozzi, A. Georgiopoulos, G. Falcone, M. Tiseo, G. Pugliese, N.R. Dimopoulos, M.A. Ghiadoni, L. Barbieri, G. Forfori, F. Carrozzi, L. Santini, M. Monzani, F. De Marco, S. Menichetti, F. Virdis, A. Masi, S. Sabrina, A.D.I. Martina, B. Matteo, B. Elia, N. Stefano, S. Rachele, A. Valeria, C. Simone, P. Rubia, B. Pietro, B. Giulia, B. Francesco, C. Alessandra, D.R. Fabio, G. Paolo, M. Marco, M. Chiara, P. Alessandro, C. Francesco, C. Naria, P. Alessandro, C. Luciano, C. Chiara, S. Valentina, G. Uliana, M. Francesca, R. Giovanna, F. Maria, S. Pisa Covid Study Group

Abstract

High sensitivity troponin T (hsTnT) is a strong predictor of adverse outcome during SARS-CoV-2 infection. However, its determinants remain partially unknown. We aimed to assess the relationship between severity of inflammatory response/coagulation abnormalities and hsTnT in Coronavirus Disease 2019 (COVID-19). We then explored the relevance of these pathways in defining mortality and complications risk and the potential effects of the treatments to attenuate such risk. In this single-center, prospective, observational study we enrolled 266 consecutive patients hospitalized for SARS-CoV-2 pneumonia. Primary endpoint was in-hospital COVID-19 mortality. hsTnT, even after adjustment for confounders, was associated with mortality. D-dimer and CRP presented stronger associations with hsTnT than PaO2. Changes of hsTnT, D-dimer and CRP were related; but only D-dimer was associated with mortality. Moreover, low molecular weight heparin showed attenuation of the mortality in the whole population, particularly in subjects with higher hsTnT. D-dimer possessed a strong relationship with hsTnT and mortality. Anticoagulation treatment showed greater benefits with regard to mortality. These findings suggest a major role of SARS-CoV-2 coagulopathy in hsTnT elevation and its related mortality in COVID-19. A better understanding of the mechanisms related to COVID-19 might pave the way to therapy tailoring in these high-risk individuals. © 2021, The Author(s).

Published
2021

22. Estimated pulse wave velocity improves risk stratification for all-cause mortality in patients with COVID-19

Author

Stamatelopoulos, K., Georgiopoulos, G., Baker, K. F., Tiseo, G., Delialis, D., Lazaridis, C., Barbieri, G., Masi, S., Vlachogiannis, N. I., Sopova, K., Mengozzi, A., Ghiadoni, L., van der Loeff, I. S., Hanrath, A. T., Ajdini, B., Vlachopoulos, C., Dimopoulos, M. A., Duncan, C. J. A., Falcone, M., Stellos, K., Monzani, F., Menichetti, F., Virdis, A., Forfori, F., Rubia, B., Pietro, B., Giulia, B., Francesco, C., Alessandra, D. R., Fabio, G., Paolo, M., Marco, M., Chiara, P., Naria, P., Alessandro, C., Carrozzi, L., Santini, M., Martina, B., Matteo, B., Elia, N., Stefano, S., Francesca, R., Giovanna, F., Maria, S., De Marco, S., Rachele, A., Valeria, C., Simone, P., Luciano, C., Chiara, S., Valentina, G., Uliana, M., Tee, S. A., Capstick, R., Marchitelli, G., Li, A., Barr, A., Eid, A., Ahmed, S., Bajwa, D., and Mohammed, O.

Subjects
Male, Comorbidity, Prognostic markers, Risk Factors, 80 and over, Medicine, Longitudinal Studies, Pulse wave velocity, Aged, 80 and over, Core (anatomy), Multidisciplinary, Middle Aged, Pulse pressure, arterial stiffness, Italy, Cardiovascular Diseases, Cohort, Cardiology, Female, medicine.medical_specialty, aortic stiffness, pulse wave velocity, Science, Predictive markers, Article, cardiovascular events, Vascular Stiffness, Internal medicine, Humans, reflections, increases, Aged, Retrospective Studies, business.industry, COVID-19, Retrospective cohort study, prediction, United Kingdom, medicine.disease, stage, pulse wave velocity, COVID-19, inflammation, Mean blood pressure, Viral infection, Arterial stiffness, business
Abstract

Accurate risk stratification in COVID-19 patients consists a major clinical need to guide therapeutic strategies. We sought to evaluate the prognostic role of estimated pulse wave velocity (ePWV), a marker of arterial stiffness which reflects overall arterial integrity and aging, in risk stratification of hospitalized patients with COVID-19. This retrospective, longitudinal cohort study, analyzed a total population of 1671 subjects consisting of 737 hospitalized COVID-19 patients consecutively recruited from two tertiary centers (Newcastle cohort: n = 471 and Pisa cohort: n = 266) and a non-COVID control cohort (n = 934). Arterial stiffness was calculated using validated formulae for ePWV. ePWV progressively increased across the control group, COVID-19 survivors and deceased patients (adjusted mean increase per group 1.89 m/s, P p P P

Published
2021

23. Abl2 knockdown affects TGFb-mediated 3D invasion of ccRCC cells

Author

DE MARCO, S, Torsello, B, Minutiello, E, Bossi, M, Bombelli, S, Grasselli, C, Bianchi, C, Perego, R, De Marco Sofia, Torsello Barbara, Minutiello Emanuela, Bossi Mario, Bombelli Silvia, Grasselli Chiara, Bianchi Cristina, Perego Roberto, DE MARCO, S, Torsello, B, Minutiello, E, Bossi, M, Bombelli, S, Grasselli, C, Bianchi, C, Perego, R, De Marco Sofia, Torsello Barbara, Minutiello Emanuela, Bossi Mario, Bombelli Silvia, Grasselli Chiara, Bianchi Cristina, and Perego Roberto

Published
2021

24. Abl2 is required for TGFb1-induced invasion of clear cell Renal Cell Carcinoma cells

Author

Torsello, B, DE MARCO, S, Bossi, M, Bombelli, S, Grasselli, C, Zucchini, N, Bianchi, C, Perego, R, Torsello Barbara, De Marco Sofia, Bossi Mario, Bombelli Silvia, Grasselli Chiara, Zucchini Nicola, Bianchi Cristina, Perego Roberto, Torsello, B, DE MARCO, S, Bossi, M, Bombelli, S, Grasselli, C, Zucchini, N, Bianchi, C, Perego, R, Torsello Barbara, De Marco Sofia, Bossi Mario, Bombelli Silvia, Grasselli Chiara, Zucchini Nicola, Bianchi Cristina, and Perego Roberto

Published
2021

25. Abl2 is involved in TGF-induced invasion and invadopodia maturation of clear cell renal cell carcinoma cells

Author

De Marco, S, Torsello, B, Bombelli, S, Grasselli, C, Zucchini, N, Lucarelli, G, Perego, R, Bianchi, C, S. De Marco, B. Torsello, S. Bombelli, C. Grasselli, N. Zucchini, G. Lucarelli, R. Perego, C. Bianchi, De Marco, S, Torsello, B, Bombelli, S, Grasselli, C, Zucchini, N, Lucarelli, G, Perego, R, Bianchi, C, S. De Marco, B. Torsello, S. Bombelli, C. Grasselli, N. Zucchini, G. Lucarelli, R. Perego, and C. Bianchi

Published
2021

29. Abstracts of the 30th Meeting of the European Renal Cell Study Group (ERCSG)

Author

De Marco, S, Bianchi, C, Torsello, B, Bombelli, S, Zucchini, N, Viganò, P, Perego, R, De Marco S., Bianchi C., Torsello B., Bombelli S., Zucchini N., Viganò P., Perego R., De Marco, S, Bianchi, C, Torsello, B, Bombelli, S, Zucchini, N, Viganò, P, Perego, R, De Marco S., Bianchi C., Torsello B., Bombelli S., Zucchini N., Viganò P., and Perego R.

Published
2018

30. 36-kDa Annexin A3 Isoform Negatively Modulates Lipid Storage in Clear Cell Renal Cell Carcinoma Cells

Author

Bombelli, S, Torsello, B, De Marco, S, Lucarelli, G, Cifola, I, Grasselli, C, Strada, G, Bovo, G, Perego, R, Bianchi, C, Bombelli, Silvia, Torsello, Barbara, De Marco, Sofia, Lucarelli, Giuseppe, Cifola, Ingrid, Grasselli, Chiara, Strada, Guido, Bovo, Giorgio, Perego, Roberto, Bianchi, Cristina, Bombelli, S, Torsello, B, De Marco, S, Lucarelli, G, Cifola, I, Grasselli, C, Strada, G, Bovo, G, Perego, R, Bianchi, C, Bombelli, Silvia, Torsello, Barbara, De Marco, Sofia, Lucarelli, Giuseppe, Cifola, Ingrid, Grasselli, Chiara, Strada, Guido, Bovo, Giorgio, Perego, Roberto, and Bianchi, Cristina

Abstract

The adipocyte-like morphology of clear cell renal cell carcinoma (ccRCC) cells results from a grade-dependent neutral lipid accumulation; however, the molecular mechanism and role in renal cancer progression have yet to be clarified. ccRCC shows a gene expression signature consistent with adipogenesis, and the phospholipid-binding protein annexin A3 (AnxA3), a negative regulator of adipocyte differentiation, is down-regulated in RCC and shows a differential expression pattern for two isoforms of 36 and 33 kDa. Using primary cell cultures and cell lines, we investigated the involvement of AnxA3 isoforms in lipid storage modulation of ccRCC cells. We found that the increased accumulation of lipids into ccRCC cells correlated with a decrease of the 36/33 isoform ratio. Treatment with adipogenic medium induced a significant increment of lipid storage in ccRCC cells that had a low 36-kDa AnxA3 expression and 36/33 ratio. The 36-kDa AnxA3 silencing in ccRCC cells increased lipid storage induced by adipogenic medium. These data suggest that 36-kDa AnxA3 negatively modulates the response to adipogenic treatment and may act as negative regulator of lipid storage in ccRCC cells. The subcellular distribution of AnxA3 in the cellular endocytic compartment suggests its involvement in modulation of vesicular trafficking, and it might serve as a putative mechanism of lipid storage regulation in ccRCC cells, opening novel translational outcomes.

Published
2020

33. Role of interactions among Arg tyrosine kinase, TGFb1 and lysyl oxidase in ccRCC progression

Author

De Marco, S, Bianchi, C, Torsello, B, Meregalli, C, Bombelli, S, Zucchini, N, Viganò, P, STRADA, GUIDO RAFFAELE, Perego, R, De Marco, S, Bianchi, C, Torsello, B, Meregalli, C, Bombelli, S, Zucchini, N, Viganò, P, Strada, G, and Perego, R

Subjects
lysyl oxidase, Arg tyrosine kinase, TGFb1, clear cell Renal Cell Carcinoma, tumor progression
Published
2018

41. Numerical approximations of McKean anticipative backward stochastic differential equations arising in initial margin requirements

Author

Agarwal, A., De Marco, S., Gobet, Emmanuel, López Salas, José Germán, Noubiagain, F., Zhou, A., Agarwal, A., De Marco, S., Gobet, Emmanuel, López Salas, José Germán, Noubiagain, F., and Zhou, A.

Abstract

[Abstract]: We introduce a new class of anticipative backward stochastic differential equations with a dependence of McKean type on the law of the solution, that we name MKABSDE. We provide existence and uniqueness results in a general framework with relatively general regularity assumptions on the coefficients. We show how such stochastic equations arise within the modern paradigm of derivative pricing where a central counterparty (CCP) requires the members to deposit variation and initial margins to cover their exposure. In the case when the initial margin is proportional to the Conditional Value-at-Risk (CVaR) of the contract price, we apply our general result to define the price as a solution of a MKABSDE. We provide several linear and non-linear simpler approximations, which we solve using different numerical (deterministic and Monte-Carlo) methods.

Published
2019

42. The 1ALCTL and 1BLCTL isoforms of Arg/Abl2 induce fibroblast activation and extra cellular matrix remodelling differently

Author

Torsello, B, DE MARCO, S, Bombelli, S, Chisci, E, Cassina, V, Corti, R, Bernasconi, D, Giovannoni, R, Bianchi, C, Perego, R, DE MARCO, SOFIA, CHISCI, ELISA, CORTI, ROBERTA, Torsello, B, DE MARCO, S, Bombelli, S, Chisci, E, Cassina, V, Corti, R, Bernasconi, D, Giovannoni, R, Bianchi, C, Perego, R, DE MARCO, SOFIA, CHISCI, ELISA, and CORTI, ROBERTA

Abstract

The fibrotic tissue and the stroma adjacent to cancer cells are characterised by the presence of activated fibroblasts (myofibroblasts) which play a role in creating a supportive tissue charac-terised by abundant extracellular matrix (ECM) secretion. The myofibroblasts remodel this tissue through secreted molecules and modulation of their cytoskeleton and specialized con-tractile structures. The non-receptor protein tyrosine kinase Arg (also called Abl2) has the unique ability to bind directly to the actin cytoskeleton, transducing diverse extracellular sig-nals into cytoskeletal rearrangements. In this study we analysed the 1ALCTL and 1BLCTL Arg isoforms in Arg-/- murine embryonal fibroblasts (MEF) cell line, focusing on their capac-ity to activate fibroblasts and to remodel ECM. The results obtained showed that Arg isoform 1BLCTL has a major role in proliferation, migration/invasion of MEF and in inducing a milieu able to modulate tumour cell morphology, while 1ALCTL isoform has a role in MEF adhesion maintaining active focal adhesions. On the whole, the presence of Arg in MEF supports the proliferation, activa-tion, adhesion, ECM contraction and stiffness, while the absence of Arg affected these myofibroblast features

Published
2019

43. Molecular interactions among Arg/abl2, TGFb and Lox and functional role in clear cell Renal Cell Carcinoma (ccRCC) progression

Author

DE MARCO, S, Bianchi, C, Torsello, B, Minutiello, E, Bombelli, S, Grasselli, C, Eriani, S, Zucchini, N, Viganò, P, Strada, G, Perego, R, De Marco Sofia, Bianchi Cristina, Torsello Barbara, Minutiello Emanuela, Bombelli Silvia, Grasselli Chiara, Eriani Stefano, Zucchini Nicola, Viganò Paolo, Strada Giorgio, Perego Roberto, DE MARCO, S, Bianchi, C, Torsello, B, Minutiello, E, Bombelli, S, Grasselli, C, Eriani, S, Zucchini, N, Viganò, P, Strada, G, Perego, R, De Marco Sofia, Bianchi Cristina, Torsello Barbara, Minutiello Emanuela, Bombelli Silvia, Grasselli Chiara, Eriani Stefano, Zucchini Nicola, Viganò Paolo, Strada Giorgio, and Perego Roberto

Published
2019

44. Molecular interaction among TGFb, Lox and Arg/Abl2 in clear cell Renal Cell carcinoma (ccRCC) and in its progression

Author

DE MARCO, S, Torsello, B, Minutiello, E, Bombelli, S, Grasselli, C, Eriani, S, Zucchini, N, Strada, G, Bianchi, C, Perego, R, De Marco Sofia, Torsello Barbara, Minutiello Emanuela, Bombelli Silvia, Grasselli Chiara, Eriani Stefano, Zucchini Nicola, Strada Guido, Bianchi Cristina, Perego Roberto, DE MARCO, S, Torsello, B, Minutiello, E, Bombelli, S, Grasselli, C, Eriani, S, Zucchini, N, Strada, G, Bianchi, C, Perego, R, De Marco Sofia, Torsello Barbara, Minutiello Emanuela, Bombelli Silvia, Grasselli Chiara, Eriani Stefano, Zucchini Nicola, Strada Guido, Bianchi Cristina, and Perego Roberto

Published
2019

45. PKHhigh/CD133+/CD24- stem-like cells isolated from human nephrospheres exibit in vitro multipotency

Author

Bombelli, S, Grasselli, C, Bolognesi, M, Bruno, A, Eriani, S, Torsello, B, DE MARCO, S, Bianchi, C, Strada, G, Zucchini, N, Albini, A, Cattoretti, G, Perego, R, Bombelli Silvia, Grasselli Chiara, Bolognesi maddalena, Bruno Antonino, Eriani Stefano, Torsello barbara, De Marco Sofia, Bianchi Cristina, Strada Guido, Zucchini Nicola, Albini Adriana, Cattoretti Giorgio, Perego Roberto, Bombelli, S, Grasselli, C, Bolognesi, M, Bruno, A, Eriani, S, Torsello, B, DE MARCO, S, Bianchi, C, Strada, G, Zucchini, N, Albini, A, Cattoretti, G, Perego, R, Bombelli Silvia, Grasselli Chiara, Bolognesi maddalena, Bruno Antonino, Eriani Stefano, Torsello barbara, De Marco Sofia, Bianchi Cristina, Strada Guido, Zucchini Nicola, Albini Adriana, Cattoretti Giorgio, and Perego Roberto

Published
2019

47. Endogenous lysyl-oxidase in clear cell renal cell carcinoma promotes tumor progression and collagen stiffness

Author

TORSELLO, BARBARA ROSA, BIANCHI, CRISTINA, CASSINA, VALERIA, CORTI, ROBERTA, MEREGALLI, CHIARA, BOMBELLI, SILVIA, STRADA, GUIDO RAFFAELE, PEREGO, ROBERTO, Di Stefano, V, Battaglia, C, Cifola, I, Mangano, E, Bovo, G, De Marco, S, Vigano’, P, Torsello, B, Di Stefano, V, Bianchi, C, Battaglia, C, Cifola, I, Mangano, E, Bovo, G, Cassina, V, De Marco, S, Corti, R, Meregalli, C, Bombelli, S, Vigano’, P, Strada, G, and Perego, R

Subjects
ccRCC, lox
Published
2016

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