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Big data technologies and analytics enable new digital services and are often associated with superior performance. However, firms investing in big data often fail to attain those advantages. To answer the questions of how and when big data pay off, marketing scholars need new theoretical approaches and empirical tools that account for the digitized world. Building on affordance theory, the authors develop a novel, conceptually rigorous, and practice-oriented framework of the impact of big data investments on service innovation and performance. Affordances represent action possibilities, namely what individuals or organizations with certain goals and capabilities can do with a technology. The authors conceptualize and operationalize three important big data marketing affordances: customer behavior pattern spotting, real-time market responsiveness, and data-driven market ambidexterity. The empirical analysis establishes construct validity and offers a preliminary nomological test of direct, indirect, and conditional effects of big data marketing affordances on perceived big data performance., Author(s): Luigi M. De Luca [sup.1] , Dennis Herhausen [sup.2] , Gabriele Troilo [sup.3] , Andrea Rossi [sup.1] [sup.4] Author Affiliations: (1) grid.5600.3, 0000 0001 0807 5670, Cardiff University Business [...]

Hydroxylammonium nitrate (HAN; NH3OH+NO3-), a green and non-toxic monopropellant, finds wide application in liquid and controllable solid propulsion. Gel propulsion enjoys advantages such as a high throttling capacity and encouraging operational safety. This study prepared three HAN-based gel propellant samples with gelling agent contents ranging from 2 to 4 wt%. Their decomposition processes were analyzed using thermogravimetry (TG), differential scanning calorimetry (DSC), and mass spectrometry (MS), and a microthruster was designed to investigate their combustion characteristics under varying voltages and flow rates. Results reveal the presence of three exothermic peaks in the HAN-based gel propellants at temperatures of 204, 306 °C and 441 °C. The gel propellants experienced violent decomposition between 100 °C and 400 °C, producing low-molecular-weight organics such as C3H8, C2H6, H2O, O2, and NH3. For the initial ignition, the flow rate exerts a greater effect of reducing the delay time than the voltage. The reignition exhibited a shorter delay time than the initial ignition, and increasing voltage led to a more significant decrease in the reignition delay time than increasing the flow rate. Under a gelling agent content of approximately 4 wt%, the reignition delay time decreased from 2.35 s to 0.65 s as the voltage increased from 150 V to 250 V, with the flame length and light intensity during the reignition greater than those in the initial ignition. At the end of combustion, the extinguishment delay time changed insignificantly under high voltage. As revealed by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) analyses, residues with numerous cavities emerged due to incomplete combustion and the severe agglomeration of the gel propellants, exhibiting a maximum chlorine content of up to 77.73%. [ABSTRACT FROM AUTHOR]

Research about innovation management explores how the future is created—who is creating it (organizations, collaborations, etc.), for what aims (customer satisfaction, market performance, etc.), and with what broader effects (social, environmental, etc.). With this extended essay, we explore the potential futures of innovation management research in three ways. First, we briefly review the history of past research agendas and priorities published in the Journal of Product Innovation Management (JPIM), highlighting three broad topic areas (technological, social/environmental, and organizational) that have emerged over time and their potential disruptive implications for innovation management research. Second, we describe the outcome of a gathering of leading scholars in innovation management tasked with the challenge of identifying critical research paths for our field. This collaboration resulted in five "deep dive" essays into areas ripe for innovation management research in the years ahead: liquid innovation, artificial intelligence in innovation, business model innovation, public value innovation, and responsible innovation. Third, we reflect on this expansive effort and offer a discussion of implications (tensions, challenges, and opportunities) for future innovation management scholarship. [ABSTRACT FROM AUTHOR]

Penile cancer, while rare, is a critical public health issue due to its profound impact on patients and the complexities of its management. The disease's multifactorial etiology includes risk factors such as HPV infection, poor hygiene, smoking, genetic predispositions, and socioeconomic determinants. This article provides a comprehensive review and analysis of these diverse risk factors, aiming to enhance understanding of the disease's underlying causes. By elucidating these factors, the article seeks to inform and improve prevention strategies, early detection methods, and therapeutic interventions. A nuanced grasp of the multifactorial nature of penile cancer can enable healthcare professionals to develop more effective approaches to reducing incidence rates and improving patient outcomes. [ABSTRACT FROM AUTHOR]

Circulating α1-acid glycoprotein (AGP) and C-reactive protein (CRP) are commonly measured to assess inflammation, but these biomarkers fail to reveal the complex molecular biology of inflammation. We mined the maternal plasma proteome to detect proteins that covary with AGP and CRP. In 435 gravida predominantly in <12-week gestation, we correlated the relative quantification of plasma proteins assessed via a multiplexed aptamer assay (SOMAScan®) with AGP and CRP, quantified by immunoassay. We defined a plasma inflammasome as protein correlates meeting a false discovery rate <0.05. We examined potential pathways using principal component analysis. A total of 147 and 879 of 6431 detected plasma proteins correlated with AGP and CRP, respectively, of which 61 overlapped with both biomarkers. Positive correlates included serum amyloid, complement, interferon-induced, and immunoregulatory proteins. Negative correlates were micronutrient and lipid transporters and pregnancy-related anabolic proteins. The principal components (PCs) of AGP were dominated by negatively correlated anabolic proteins associated with gestational homeostasis, angiogenesis, and neurogenesis. The PCs of CRP were more diverse in function, reflecting cell surface and adhesion, embryogenic, and intracellular and extra-hepatic tissue leakage proteins. The plasma proteome of AGP or CRP reveals wide proteomic variation associated with early gestational inflammation, suggesting mechanisms and pathways that merit future research. [ABSTRACT FROM AUTHOR]

Bladder cancer ranks as the 10th most prevalent cancer globally with an increasing incidence. Radical cystectomy combined with urinary diversion represents the standard treatment for muscle-invasive bladder cancer, offering a range of techniques tailored to patient factors. Overall, urinary diversions are divided into non-continent and continent. Among the first category, cutaneous ureterostomy and ileal conduit represent the most common procedures while in the second category, it could be possible to describe another subclassification which includes ureterosigmoidostomy, continent diversions requiring catheterization and orthotopic voiding pouches and neobladders. In this comprehensive review, urinary diversions are described in their technical aspects, providing a summary of almost all alternatives to urinary diversion post-radical cystectomy. [ABSTRACT FROM AUTHOR]

This study delves into the construction of reduced-order models (ROMs) of a flow field over a NACA 0012 airfoil at a moderate Reynolds number and an angle of attack of 8 ∘ . Numerical simulations were computed through the finite-volume solver OpenFOAM. The analysis considers two different reduction techniques: the standard Galerkin projection method, which involves projecting the governing equations onto proper orthogonal decomposition modes (POD−ROMs), and the cluster-based network model (CNM), a fully data-driven nonlinear approach. An analysis of the topology of the dominant POD modes was conducted, uncovering a traveling wave pattern in the wake dynamics. We compared the performances of both ROM techniques regarding their prediction of flow field behavior and integral quantities. The ROM framework facilitates the practical actuation of control strategies with significantly reduced computational demands compared to the full-order approach. [ABSTRACT FROM AUTHOR]

This study reports the first time-resolved particle image velocimetry characterization of a planar two-phase mixing layer flow, whose velocity field is measured simultaneously in gas and liquid streams. Two parallel air and water flows meet downstream of a splitter plate, giving rise to an initially spanwise invariant configuration. The aim is to elucidate further the mechanisms leading to the flow breakup in gas-assisted atomization. The complete experimental characterization of the velocity field represents a database that could be used in data-driven reduced-order models to investigate the global behaviour of the flow system. After the analysis of a selected reference case, a parametric study of the flow behaviour is performed by varying the liquid (Rel) and gas (Reg) Reynolds numbers, and as a consequence also the gas-to-liquid dynamic pressure ratio (M), shedding light on both time-averaged (mean) and unsteady velocity fields. In the reference case, it is shown that the mean flow exhibits a wake region just downstream of the splitter plate, followed by the development of a mixing layer. By increasing both Rel and Reg, the streamwise extent of the wake decreases and eventually vanishes, the flow resulting in a pure mixing layer regime. The spectral analysis of the normal-to-flow velocity fluctuations outlines different flow regimes by variation of the governing parameters, giving more insights into the global characteristics of the flow field. As a major result, it is found that at high Reg and M values, the velocity fluctuations are characterized by low-frequency temporal oscillations synchronized in several locations within the flow field, which suggest the presence of a global mode of instability. The proper orthogonal decomposition of velocity fluctuations, performed in both gas and liquid phases, reveals finally that the synchronized oscillations are associated with a low-frequency dominant flapping mode of the gas-liquid interface. Higher-order modes correspond to interfacial wave structures travelling with the so-called Dimotakis velocity. For lower gas Reynolds numbers, the leading modes describe higher frequency fingers shedding at the interface. [ABSTRACT FROM AUTHOR]

Egyptian women's religious expressions in papyrus letters (Bagnall and Cribiore, 2006) were divided into five categories: None , no god(s) mentioned; Pray , containing "Pray" without gods; Gods , for Greek Gods; Sarapis/local Gods/ προσκυνήµα for letters containing prayers in which obeisance before a God is expressed in the Egyptian reverential manner, a προσκυνήµα ; Θεός / Κύριος / Χριστός letters to the Christian God. The None category is prevalent during the early 300 BC to 100 AD period followed by an increase in, and then stable, formulaic/religious expressions. The Pray category peaked in the second and third centuries AD, and the Gods category, referring to pagan Gods, showed a steady and significant decline from the first to the fourth century AD inverse to the rise in prevalence of letters in the Θεός / Κύριος / Χριστός category. The shift to monotheism with Christianity is rendered in graphic form, and permits an appreciation of feminine popular sentiment on religion and its Gods in Egypt. [ABSTRACT FROM AUTHOR]