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1. Defective DNA repair mechanisms in prostate cancer: impact of olaparib

Author

De Felice F, Tombolini V, Marampon F, Musella A, and Marchetti C

Subjects
prostate cancer, metastatic disease, castration-resistant, BRCA, DNA-repair, PARP, olaparib., Therapeutics. Pharmacology, RM1-950
Abstract

Francesca De Felice,1 Vincenzo Tombolini,1 Francesco Marampon,2 Angela Musella,3 Claudia Marchetti3 1Department of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, Rome, 2Department of Biotechnological and Applied Clinical Sciences, Laboratory of Radiobiology, University of L’Aquila, L’Aquila, 3Department of Gynecological and Obstetrical Sciences and Urological Sciences, “Sapienza” University of Rome, Rome, Italy Abstract: The field of prostate oncology has continued to change dramatically. It has truly become a field that is intensely linked to molecular genetic alterations, especially DNA-repair defects. Germline breast cancer 1 gene (BRCA1) and breast cancer 2 gene (BRCA2) mutations are implicated in the highest risk of prostate cancer (PC) predisposition and aggressiveness. Poly adenosine diphosphate ribose polymerase (PARP) proteins play a key role in DNA repair mechanisms and represent a valid target for new therapies. Olaparib is an oral PARP inhibitor that blocks DNA repair pathway and coupled with BRCA mutated-disease results in tumor cell death. In phase II clinical trials, including patients with advanced castration-resistant PC, olaparib seems to be efficacious and well tolerated. Waiting for randomized phase III trials, olaparib should be considered as a promising treatment option for PC. Keywords: prostate cancer, metastatic disease, castration resistant, BRCA, DNA-repair, PARP, olaparib

Published
2017

2. Intensified Total Neoadjuvant Therapy in Patients With Locally Advanced Rectal Cancer: Long-term Results of a Prospective Phase II Study

Author

De Felice, F., Archetti, L., D'Ambrosio, G., Iafrate, F., Picone, V., Magliocca, F.M., Musio, D., Roberto, M., Casella, G., Clementi, I., Bulzonetti, N., Picchetto, A., Vitti, E., Merenda, E., Gentili, C., Lanzilao, M., Miccini, M., Illuminati, G., Delle Donne, A., Crocetti, D., Minozzi, M., Mongardini, M., Caronna, R., Fiori, E., and Cortesi, E.

Published
2025
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3. Gaia Data Release 2: The astrometric solution

Author

Lindegren, L., Hernandez, J., Bombrun, A., Klioner, S., Bastian, U., Ramos-Lerate, M., de Torres, A., Steidelmuller, H., Stephenson, C., Hobbs, D., Lammers, U., Biermann, M., Geyer, R., Hilger, T., Michalik, D., Stampa, U., McMillan, P. J., Castaneda, J., Clotet, M., Comoretto, G., Davidson, M., Fabricius, C., Gracia, G., Hambly, N. C., Hutton, A., Mora, A., Portell, J., van Leeuwen, F., Abbas, U., Abreu, A., Altmann, M., Andrei, A., Anglada, E., Balaguer-Nunez, L., Barache, C., Becciani, U., Bertone, S., Bianchi, L., Bouquillon, S., Bourda, G., Brusemeister, T., Bucciarelli, B., Busonero, D., Buzzi, R., Cancelliere, R., Carlucci, T., Charlot, P., Cheek, N., Crosta, M., Crowley, C., de Bruijne, J., de Felice, F., Drimmel, R., Esquej, P., Fienga, A., Fraile, E., Gai, M., Garralda, N., Gonzalez-Vidal, J. J., Guerra, R., Hauser, M., Hofmann, W., Holl, B., Jordan, S., Lattanzi, M. G., Lenhardt, H., Liao, S., Licata, E., Lister, T., Loffler, W., Marchant, J., Martin-Fleitas, J. -M., Messineo, R., Mignard, F., Morbidelli, R., Poggio, E., Riva, A., Rowell, N., Salguero, E., Sarasso, M., Sciacca, E., Siddiqui, H., Smart, R. L., Spagna, A., Steele, I., Taris, F., Torra, J., van Elteren, A., van Reeven, W., and Vecchiato, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Gaia Data Release 2 (Gaia DR2) contains results for 1693 million sources in the magnitude range 3 to 21 based on observations collected by the European Space Agency Gaia satellite during the first 22 months of its operational phase. We describe the input data, models, and processing used for the astrometric content of Gaia DR2, and the validation of these results performed within the astrometry task. Some 320 billion centroid positions from the pre-processed astrometric CCD observations were used to estimate the five astrometric parameters (positions, parallaxes, and proper motions) for 1332 million sources, and approximate positions at the reference epoch J2015.5 for an additional 361 million mostly faint sources. Special validation solutions were used to characterise the random and systematic errors in parallax and proper motion. For the sources with five-parameter astrometric solutions, the median uncertainty in parallax and position at the reference epoch J2015.5 is about 0.04 mas for bright (G<14 mag) sources, 0.1 mas at G=17 mag, and 0.7 mas at G=20 mag. In the proper motion components the corresponding uncertainties are 0.05, 0.2, and 1.2 mas/yr, respectively. The optical reference frame defined by Gaia DR2 is aligned with ICRS and is non-rotating with respect to the quasars to within 0.15 mas/yr. From the quasars and validation solutions we estimate that systematics in the parallaxes depending on position, magnitude, and colour are generally below 0.1 mas, but the parallaxes are on the whole too small by about 0.03 mas. Significant spatial correlations of up to 0.04 mas in parallax and 0.07 mas/yr in proper motion are seen on small (<1 deg) and intermediate (20 deg) angular scales. Important statistics and information for the users of the Gaia DR2 astrometry are given in the appendices., Comment: 25 pages, 29 figures. Special A&A issue on Gaia Data Release 2

Published
2018
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4. Gaia Data Release 1. Testing the parallaxes with local Cepheids and RR Lyrae stars

Author

Gaia Collaboration, Clementini, G., Eyer, L., Ripepi, V., Marconi, M., Muraveva, T., Garofalo, A., Sarro, L. M., Palmer, M., Luri, X., Molinaro, R., Rimoldini, L., Szabados, L., Musella, I., Anderson, R. I., Prusti, T., de Bruijne, J. H. J., Brown, A. G. A., Vallenari, A., Babusiaux, C., Bailer-Jones, C. A. L., Bastian, U., Biermann, M., Evans, D. W., Jansen, F., Jordi, C., Klioner, S. A., Lammers, U., Lindegren, L., Mignard, F., Panem, C., Pourbaix, D., Randich, S., Sartoretti, P., Siddiqui, H. I., Soubiran, C., Valette, V., van Leeuwen, F., Walton, N. A., Aerts, C., Arenou, F., Cropper, M., Drimmel, R., Høg, E., Katz, D., Lattanzi, M. G., O'Mullane, W., Grebel, E. K., Holland, A. D., Huc, C., Passot, X., Perryman, M., Bramante, L., Cacciari, C., Castañeda, J., Chaoul, L., Cheek, N., De Angeli, F., Fabricius, C., Guerra, R., Hernández, J., Jean-Azntoine-Piccolo, A., Masana, E., Messineo, R., Mowlavi, N., Nienartowicz, K., Ordóñez-Blanco, D., Panuzzo, P., Portell, J., Richards, P. J., Riello, M., Seabroke, G. M., Tanga, P., Thévenin, F., Torra, J., Els, S. G., Gracia-Abril, G., Comoretto, G., Garcia-Reinaldos, M., Lock, T., Mercier, E., Altmann, M., Andrae, R., Astraatmadja, T. L., Bellas-Velidis, I., Benson, K., Berthier, J., Blomme, R., Busso, G., Carry, B., Cellino, A., Cowell, S., Creevey, O., Cuypers, J., Davidson, M., De Ridder, J., de Torres, A., Delchambre, L., Dell'Oro, A., Ducourant, C., Frémat, Y., García-Torres, M., Gosset, E., Halbwachs, J. -L., Hambly, N. C., Harrison, D. L., Hauser, M., Hestroffer, D., Hodgkin, S. T., Huckle, H. E., Hutton, A., Jasniewicz, G., Jordan, S., Kontizas, M., Korn, A. J., Lanzafame, A. C., Manteiga, M., Moitinho, A., Muinonen, K., Osinde, J., Pancino, E., Pauwels, T., Petit, J. -M., Recio-Blanco, A., Robin, A. C., Siopis, C., Smith, M., Smith, K. W., Sozzetti, A., Thuillot, W., van Reeven, W., Viala, Y., Abbas, U., Aramburu, A. Abreu, Accart, S., Aguado, J. J., Allan, P. M., Allasia, W., Altavilla, G., Álvarez, M. A., Alves, J., Andrei, A. H., Varela, E. Anglada, Antiche, E., Antoja, T., Antón, S., Arcay, B., Bach, N., Baker, S. G., Balaguer-Núñez, L., Barache, C., Barata, C., Barbier, A., Barblan, F., Navascués, D. Barrado y, Barros, M., Barstow, M. A., Becciani, U., Bellazzini, M., García, A. Bello, Belokurov, V., Bendjoya, P., Berihuete, A., Bianchi, L., Bienaymé, O., Billebaud, F., Blagorodnova, N., Blanco-Cuaresma, S., Boch, T., Bombrun, A., Borrachero, R., Bouquillon, S., Bourda, G., Bouy, H., Bragaglia, A., Breddels, M. A., Brouillet, N., Brüsemeister, T., Bucciarelli, B., Burgess, P., Burgon, R., Burlacu, A., Busonero, D., Buzzi, R., Caffau, E., Cambras, J., Campbell, H., Cancelliere, R., Cantat-Gaudin, T., Carlucci, T., Carrasco, J. M., Castellani, M., Charlot, P., Charnas, J., Chiavassa, A., Clotet, M., Cocozza, G., Collins, R. S., Costigan, G., Crifo, F., Cross, N. J. G., Crosta, M., Crowley, C., Dafonte, C., Damerdji, Y., Dapergolas, A., David, P., David, M., De Cat, P., de Felice, F., de Laverny, P., De Luise, F., De March, R., de Souza, R., Debosscher, J., del Pozo, E., Delbo, M., Delgado, A., Delgado, H. E., Di Matteo, P., Diakite, S., Distefano, E., Dolding, C., Anjos, S. Dos, Drazinos, P., Durán, J., Dzigan, Y., Edvardsson, B., Enke, H., Evans, N. W., Bontemps, G. Eynard, Fabre, C., Fabrizio, M., Faigler, S., Falcão, A. J., Casas, M. Farràs, Federici, L., Fedorets, G., Fernández-Hernánde, J., Fernique, P., Fienga, A., Figueras, F., Filippi, F., Findeisen, K., Fonti, A., Fouesneau, M., Fraile, E., Fraser, M., Fuchs, J., Gai, M., Galleti, S., Galluccio, L., Garabato, D., García-Sedano, F., Garralda, N., Gavras, P., Gerssen, J., Geyer, R., Gilmore, G., Girona, S., Giuffrida, G., Gomes, M., González-Marcos, A., González-Núñez, J., González-Vidal, J. J., Granvik, M., Guerrier, A., Guillout, P., Guiraud, J., Gúrpide, A., Gutiérrez-Sánchez, R., Guy, L. P., Haigron, R., Hatzidimitriou, D., Haywood, M., Heiter, U., Helmi, A., Hobbs, D., Hofmann, W., Holl, B., Holland, G., Hunt, J. A. S., Hypki, A., Icardi, V., Irwin, M., de Fombelle, G. Jevardat, Jofré, P., Jonker, P. G., Jorissen, A., Julbe, F., Karampelas, A., Kochoska, A., Kohley, R., Kolenberg, K., Kontizas, E., Koposov, S. E., Kordopatis, G., Koubsky, P., Krone-Martins, A., Kudryashova, M., Kull, I., Bachchan, R. K., Lacoste-Seris, F., Lanza, A. F., Lavigne, J. -B., Poncin-Lafitte, C. Le, Lebreton, Y., Lebzelter, T., Leccia, S., Leclerc, N., Lecoeur-Taibi, I., Lemaitre, V., Lenhardt, H., Leroux, F., Liao, S., Licata, E., Lindstrøm, H. E. P., Lister, T. A., Livanou, E., Lobel, A., Löffler, W., López, M., Lorenz, D., MacDonald, I., Fernandes, T. Magalhães, Managau, S., Mann, R. G., Mantelet, G., Marchal, O., Marchant, J. M., Marinoni, S., Marrese, P. M., Marschalkó, G., Marshall, D. J., Martín-Fleitas, J. M., Martino, M., Mary, N., Matijevič, G., Mazeh, T., McMillan, P. J., Messina, S., Michalik, D., Millar, N. R., Miranda, B. M. H., Molina, D., Molinaro, M., Molnár, L., Moniez, M., Montegriffo, P., Mor, R., Mora, A., Morbidelli, R., Morel, T., Morgenthaler, S., Morris, D., Mulone, A. F., Narbonne, J., Nelemans, G., Nicastro, L., Noval, L., Ordénovic, C., Ordieres-Meré, J., Osborne, P., Pagani, C., Pagano, I., Pailler, F., Palacin, H., Palaversa, L., Parsons, P., Pecoraro, M., Pedrosa, R., Pentikäinen, H., Pichon, B., Piersimoni, A. M., Pineau, F. -X., Plachy, E., Plum, G., Poujoulet, E., Prša, A., Pulone, L., Ragaini, S., Rago, S., Rambaux, N., Ramos-Lerate, M., Ranalli, P., Rauw, G., Read, A., Regibo, S., Reylé, C., Ribeiro, R. A., Riva, A., Rixon, G., Roelens, M., Romero-Gómez, M., Rowell, N., Royer, F., Ruiz-Dern, L., Sadowski, G., Sellés, T. Sagristà, Sahlmann, J., Salgado, J., Salguero, E., Sarasso, M., Savietto, H., Schultheis, M., Sciacca, E., Segol, M., Segovia, J. C., Segransan, D., Shih, I-C., Smareglia, R., Smart, R. L., Solano, E., Solitro, F., Sordo, R., Nieto, S. Soria, Souchay, J., Spagna, A., Spoto, F., Stampa, U., Steele, I. A., Steidelmüller, H., Stephenson, C. A., Stoev, H., Suess, F. F., Süveges, M., Surdej, J., Szegedi-Elek, E., Tapiador, D., Taris, F., Tauran, G., Taylor, M. B., Teixeira, R., Terrett, D., Tingley, B., Trager, S. C., Turon, C., Ulla, A., Utrilla, E., Valentini, G., van Elteren, A., Van Hemelryck, E., van Leeuwen, M., Varadi, M., Vecchiato, A., Veljanoski, J., Via, T., Vicente, D., Vogt, S., Voss, H., Votruba, V., Voutsinas, S., Walmsley, G., Weiler, M., Weingrill, K., Wevers, T., Wyrzykowski, Ł., Yoldas, A., Žerjal, M., Zucker, S., Zurbach, C., Zwitter, T., Alecu, A., Allen, M., Prieto, C. Allende, Amorim, A., Anglada-Escudé, G., Arsenijevic, V., Azaz, S., Balm, P., Beck, M., Bernstein, H. -H., Bigot, L., Bijaoui, A., Blasco, C., Bonfigli, M., Bono, G., Boudreault, S., Bressan, A., Brown, S., Brunet, P. -M., Bunclark, P., Buonanno, R., Butkevich, A. G., Carret, C., Carrion, C., Chemin, L., Chéreau, F., Corcione, L., Darmigny, E., de Boer, K. S., de Teodoro, P., de Zeeuw, P. T., Luche, C. Delle, Domingues, C. D., Dubath, P., Fodor, F., Frézouls, B., Fries, A., Fustes, D., Fyfe, D., Gallardo, E., Gallegos, J., Gardiol, D., Gebran, M., Gomboc, A., Gómez, A., Grux, E., Gueguen, A., Heyrovsky, A., Hoar, J., Iannicola, G., Parache, Y. Isasi, Janotto, A. -M., Joliet, E., Jonckheere, A., Keil, R., Kim, D. -W., Klagyivik, P., Klar, J., Knude, J., Kochukhov, O., Kolka, I., Kos, J., Kutka, A., Lainey, V., LeBouquin, D., Liu, C., Loreggia, D., Makarov, V. V., Marseille, M. G., Martayan, C., Martinez-Rubi, O., Massart, B., Meynadier, F., Mignot, S., Munari, U., Nguyen, A. -T., Nordlander, T., O'Flaherty, K. S., Ocvirk, P., Sanz, A. Olias, Ortiz, P., Osorio, J., Oszkiewicz, D., Ouzounis, A., Park, P., Pasquato, E., Peltzer, C., Peralta, J., Péturaud, F., Pieniluoma, T., Pigozzi, E., Poels, J., Prat, G., Prod'homme, T., Raison, F., Rebordao, J. M., Risquez, D., Rocca-Volmerange, B., Rosen, S., Ruiz-Fuertes, M. I., Russo, F., Sembay, S., Vizcaino, I. Serraller, Short, A., Siebert, A., Silva, H., Sinachopoulos, D., Slezak, E., Soffel, M., Sosnowska, D., Straižys, V., ter Linden, M., Terrell, D., Theil, S., Tiede, C., Troisi, L., Tsalmantza, P., Tur, D., Vaccari, M., Vachier, F., Valles, P., Van Hamme, W., Veltz, L., Virtanen, J., Wallut, J. -M., Wichmann, R., Wilkinson, M. I., Ziaeepour, H., and Zschocke, S.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

Parallaxes for 331 classical Cepheids, 31 Type II Cepheids and 364 RR Lyrae stars in common between Gaia and the Hipparcos and Tycho-2 catalogues are published in Gaia Data Release 1 (DR1) as part of the Tycho-Gaia Astrometric Solution (TGAS). In order to test these first parallax measurements of the primary standard candles of the cosmological distance ladder, that involve astrometry collected by Gaia during the initial 14 months of science operation, we compared them with literature estimates and derived new period-luminosity ($PL$), period-Wesenheit ($PW$) relations for classical and Type II Cepheids and infrared $PL$, $PL$-metallicity ($PLZ$) and optical luminosity-metallicity ($M_V$-[Fe/H]) relations for the RR Lyrae stars, with zero points based on TGAS. The new relations were computed using multi-band ($V,I,J,K_{\mathrm{s}},W_{1}$) photometry and spectroscopic metal abundances available in the literature, and applying three alternative approaches: (i) by linear least squares fitting the absolute magnitudes inferred from direct transformation of the TGAS parallaxes, (ii) by adopting astrometric-based luminosities, and (iii) using a Bayesian fitting approach. TGAS parallaxes bring a significant added value to the previous Hipparcos estimates. The relations presented in this paper represent first Gaia-calibrated relations and form a "work-in-progress" milestone report in the wait for Gaia-only parallaxes of which a first solution will become available with Gaia's Data Release 2 (DR2) in 2018., Comment: 29 pages, 25 figures. Accepted for publication by A&A

Published
2017
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5. Gaia Data Release 1. Open cluster astrometry: performance, limitations, and future prospects

Author

Gaia Collaboration, van Leeuwen, F., Vallenari, A., Jordi, C., Lindegren, L., Bastian, U., Prusti, T., de Bruijne, J. H. J., Brown, A. G. A., Babusiaux, C., Bailer-Jones, C. A. L., Biermann, M., Evans, D. W., Eyer, L., Jansen, F., Klioner, S. A., Lammers, U., Luri, X., Mignard, F., Panem, C., Pourbaix, D., Randich, S., Sartoretti, P., Siddiqui, H. I., Soubiran, C., Valette, V., Walton, N. A., Aerts, C., Arenou, F., Cropper, M., Drimmel, R., Høg, E., Katz, D., Lattanzi, M. G., O'Mullane, W., Grebel, E. K., Holland, A. D., Huc, C., Passot, X., Perryman, M., Bramante, L., Cacciari, C., Castañeda, J., Chaoul, L., Cheek, N., De Angeli, F., Fabricius, C., Guerra, R., Hernández, J., Jean-Antoine-Piccolo, A., Masana, E., Messineo, R., Mowlavi, N., Nienartowicz, K., Ordóñez-Blanco, D., Panuzzo, P., Portell, J., Richards, P. J., Riello, M., Seabroke, G. M., Tanga, P., Thévenin, F., Torra, J., Els, S. G., Gracia-Abril, G., Comoretto, G., Garcia-Reinaldos, M., Lock, T., Mercier, E., Altmann, M., Andrae, R., Astraatmadja, T. L., Bellas-Velidis, I., Benson, K., Berthier, J., Blomme, R., Busso, G., Carry, B., Cellino, A., Clementini, G., Cowell, S., Creevey, O., Cuypers, J., Davidson, M., De Ridder, J., de Torres, A., Delchambre, L., Dell'Oro, A., Ducourant, C., Frémat, Y., García-Torres, M., Gosset, E., Halbwachs, J. -L., Hambly, N. C., Harrison, D. L., Hauser, M., Hestroffer, D., Hodgkin, S. T., Huckle, H. E., Hutton, A., Jasniewicz, G., Jordan, S., Kontizas, M., Korn, A. J., Lanzafame, A. C., Manteiga, M., Moitinho, A., Muinonen, K., Osinde, J., Pancino, E., Pauwels, T., Petit, J. -M., Recio-Blanco, A., Robin, A. C., Sarro, L. M., Siopis, C., Smith, M., Smith, K. W., Sozzetti, A., Thuillot, W., van Reeven, W., Viala, Y., Abbas, U., Aramburu, A. Abreu, Accart, S., Aguado, J. J., Allan, P. M., Allasia, W., Altavilla, G., Álvarez, M. A., Alves, J., Anderson, R. I., Andrei, A. H., Varela, E. Anglada, Antiche, E., Antoja, T., Antón, S., Arcay, B., Bach, N., Baker, S. G., Balaguer-Núñez, L., Barache, C., Barata, C., Barbier, A., Barblan, F., Navascués, D. Barrado y, Barros, M., Barstow, M. A., Becciani, U., Bellazzini, M., García, A. Bello, Belokurov, V., Bendjoya, P., Berihuete, A., Bianchi, L., Bienaymé, O., Billebaud, F., Blagorodnova, N., Blanco-Cuaresma, S., Boch, T., Bombrun, A., Borrachero, R., Bouquillon, S., Bourda, G., Bouy, H., Bragaglia, A., Breddels, M. A., Brouillet, N., Brüsemeister, T., Bucciarelli, B., Burgess, P., Burgon, R., Burlacu, A., Busonero, D., Buzzi, R., Caffau, E., Cambras, J., Campbell, H., Cancelliere, R., Cantat-Gaudin, T., Carlucci, T., Carrasco, J. M., Castellani, M., Charlot, P., Charnas, J., Chiavassa, A., Clotet, M., Cocozza, G., Collins, R. S., Costigan, G., Crifo, F., Cross, N. J. G., Crosta, M., Crowley, C., Dafonte, C., Damerdji, Y., Dapergolas, A., David, P., David, M., De Cat, P., de Felice, F., de Laverny, P., De Luise, F., De March, R., de Martino, D., de Souza, R., Debosscher, J., del Pozo, E., Delbo, M., Delgado, A., Delgado, H. E., Di Matteo, P., Diakite, S., Distefano, E., Dolding, C., Anjos, S. Dos, Drazinos, P., Durán, J., Dzigan, Y., Edvardsson, B., Enke, H., Evans, N. W., Bontemps, G. Eynard, Fabre, C., Fabrizio, M., Faigler, S., Falcão, A. J., Casas, M. Farràs, Federici, L., Fedorets, G., Fernández-Hernández, J., Fernique, P., Fienga, A., Figueras, F., Filippi, F., Findeisen, K., Fonti, A., Fouesneau, M., Fraile, E., Fraser, M., Fuchs, J., Gai, M., Galleti, S., Galluccio, L., Garabato, D., García-Sedano, F., Garofalo, A., Garralda, N., Gavras, P., Gerssen, J., Geyer, R., Gilmore, G., Girona, S., Giuffrida, G., Gomes, M., González-Marcos, A., González-Núñez, J., González-Vidal, J. J., Granvik, M., Guerrier, A., Guillout, P., Guiraud, J., Gúrpide, A., Gutiérrez-Sánchez, R., Guy, L. P., Haigron, R., Hatzidimitriou, D., Haywood, M., Heiter, U., Helmi, A., Hobbs, D., Hofmann, W., Holl, B., Holland, G., Hunt, J. A. S., Hypki, A., Icardi, V., Irwin, M., de Fombelle, G. Jevardat, Jofré, P., Jonker, P. G., Jorissen, A., Julbe, F., Karampelas, A., Kochoska, A., Kohley, R., Kolenberg, K., Kontizas, E., Koposov, S. E., Kordopatis, G., Koubsky, P., Krone-Martins, A., Kudryashova, M., Kull, I., Bachchan, R. K., Lacoste-Seris, F., Lanza, A. F., Lavigne, J. -B., Poncin-Lafitte, C. Le, Lebreton, Y., Lebzelter, T., Leccia, S., Leclerc, N., Lecoeur-Taibi, I., Lemaitre, V., Lenhardt, H., Leroux, F., Liao, S., Licata, E., Lindstrøm, H. E. P., Lister, T. A., Livanou, E., Lobel, A., Löffer, W., López, M., Lorenz, D., MacDonald, I., Fernandes, T. Magalhães, Managau, S., Mann, R. G., Mantelet, G., Marchal, O., Marchant, J. M., Marconi, M., Marinoni, S., Marrese, P. M., Marschalkó, G., Marshall, D. J., Martín-Fleitas, J. M., Martino, M., Mary, N., Matijevič, G., Mazeh, T., McMillan, P. J., Messina, S., Michalik, D., Millar, N. R., Miranda, B. M. H., Molina, D., Molinaro, R., Molinaro, M., Molnár, L., Moniez, M., Montegrio, P., Mor, R., Mora, A., Morbidelli, R., Morel, T., Morgenthaler, S., Morris, D., Mulone, A. F., Muraveva, T., Musella, I., Narbonne, J., Nelemans, G., Nicastro, L., Noval, L., Ordénovic, C., Ordieres-Meré, J., Osborne, P., Pagani, C., Pagano, I., Pailler, F., Palacin, H., Palaversa, L., Parsons, P., Pecoraro, M., Pedrosa, R., Pentikäinen, H., Pichon, B., Piersimoni, A. M., Pineau, F. -X., Plachy, E., Plum, G., Poujoulet, E., Prša, A., Pulone, L., Ragaini, S., Rago, S., Rambaux, N., Ramos-Lerate, M., Ranalli, P., Rauw, G., Read, A., Regibo, S., Reylé, C., Ribeiro, R. A., Rimoldini, L., Ripepi, V., Riva, A., Rixon, G., Roelens, M., Romero-Gómez, M., Rowell, N., Royer, F., Ruiz-Dern, L., Sadowski, G., Sellés, T. Sagristà, Sahlmann, J., Salgado, J., Salguero, E., Sarasso, M., Savietto, H., Schultheis, M., Sciacca, E., Segol, M., Segovia, J. C., Segransan, D., Shih, I-C., Smareglia, R., Smart, R. L., Solano, E., Solitro, F., Sordo, R., Nieto, S. Soria, Souchay, J., Spagna, A., Spoto, F., Stampa, U., Steele, I. A., Steidelmüller, H., Stephenson, C. A., Stoev, H., Suess, F. F., Süveges, M., Surdej, J., Szabados, L., Szegedi-Elek, E., Tapiador, D., Taris, F., Tauran, G., Taylor, M. B., Teixeira, R., Terrett, D., Tingley, B., Trager, S. C., Turon, C., Ulla, A., Utrilla, E., Valentini, G., van Elteren, A., Van Hemelryck, E., van Leeuwen, M., Varadi, M., Vecchiato, A., Veljanoski, J., Via, T., Vicente, D., Vogt, S., Voss, H., Votruba, V., Voutsinas, S., Walmsley, G., Weiler, M., Weingril, K., Wevers, T., Wyrzykowski, Ł., Yoldas, A., Žerjal, M., Zucker, S., Zurbach, C., Zwitter, T., Alecu, A., Allen, M., Prieto, C. Allende, Amorim, A., Anglada-Escudé, G., Arsenijevic, V., Azaz, S., Balm, P., Beck, M., Bernsteiny, H. -H., Bigot, L., Bijaoui, A., Blasco, C., Bonfigli, M., Bono, G., Boudreault, S., Bressan, A., Brown, S., Brunet, P. -M., Bunclarky, P., Buonanno, R., Butkevich, A. G., Carret, C., Carrion, C., Chemin, L., Chéreau, F., Corcione, L., Darmigny, E., de Boer, K. S., de Teodoro, P., de Zeeuw, P. T., Luche, C. Delle, Domingues, C. D., Dubath, P., Fodor, F., Frézouls, B., Fries, A., Fustes, D., Fyfe, D., Gallardo, E., Gallegos, J., Gardio, D., Gebran, M., Gomboc, A., Gómez, A., Grux, E., Gueguen, A., Heyrovsky, A., Hoar, J., Iannicola, G., Parache, Y. Isasi, Janotto, A. -M., Joliet, E., Jonckheere, A., Keil, R., Kim, D. -W., Klagyivik, P., Klar, J., Knude, J., Kochukhov, O., Kolka, I., Kos, J., Kutka, A., Lainey, V., LeBouquin, D., Liu, C., Loreggia, D., Makarov, V. V., Marseille, M. G., Martayan, C., Martinez-Rubi, O., Massart, B., Meynadier, F., Mignot, S., Munari, U., Nguyen, A. -T., Nordlander, T., O'Flaherty, K. S., Ocvirk, P., Sanz, A. Olias, Ortiz, P., Osorio, J., Oszkiewicz, D., Ouzounis, A., Palmer, M., Park, P., Pasquato, E., Peltzer, C., Peralta, J., Péturaud, F., Pieniluoma, T., Pigozzi, E., Poelsy, J., Prat, G., Prod'homme, T., Raison, F., Rebordao, J. M., Risquez, D., Rocca-Volmerange, B., Rosen, S., Ruiz-Fuertes, M. I., Russo, F., Sembay, S., Vizcaino, I. Serraller, Short, A., Siebert, A., Silva, H., Sinachopoulos, D., Slezak, E., Soffel, M., Sosnowska, D., Straižys, V., ter Linden, M., Terrell, D., Theil, S., Tiede, C., Troisi, L., Tsalmantza, P., Tur, D., Vaccari, M., Vachier, F., Valles, P., Van Hamme, W., Veltz, L., Virtanen, J., Wallut, J. -M., Wichmann, R., Wilkinson, M. I., Ziaeepour, H., and Zschocke, S.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

Context. The first Gaia Data Release contains the Tycho-Gaia Astrometric Solution (TGAS). This is a subset of about 2 million stars for which, besides the position and photometry, the proper motion and parallax are calculated using Hipparcos and Tycho-2 positions in 1991.25 as prior information. Aims. We investigate the scientific potential and limitations of the TGAS component by means of the astrometric data for open clusters. Methods. Mean cluster parallax and proper motion values are derived taking into account the error correlations within the astrometric solutions for individual stars, an estimate of the internal velocity dispersion in the cluster, and, where relevant, the effects of the depth of the cluster along the line of sight. Internal consistency of the TGAS data is assessed. Results. Values given for standard uncertainties are still inaccurate and may lead to unrealistic unit-weight standard deviations of least squares solutions for cluster parameters. Reconstructed mean cluster parallax and proper motion values are generally in very good agreement with earlier Hipparcos-based determination, although the Gaia mean parallax for the Pleiades is a significant exception. We have no current explanation for that discrepancy. Most clusters are observed to extend to nearly 15 pc from the cluster centre, and it will be up to future Gaia releases to establish whether those potential cluster-member stars are still dynamically bound to the clusters. Conclusions. The Gaia DR1 provides the means to examine open clusters far beyond their more easily visible cores, and can provide membership assessments based on proper motions and parallaxes. A combined HR diagram shows the same features as observed before using the Hipparcos data, with clearly increased luminosities for older A and F dwarfs., Comment: Accepted for publication by A&A. 21 pages main text plus 46 pages appendices. 34 figures main text, 38 figures appendices. 8 table in main text, 19 tables in appendices

Published
2017
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9. Gaia Data Release 1: Astrometry - one billion positions, two million proper motions and parallaxes

Author

Lindegren, L., Lammers, U., Bastian, U., Hernández, J., Klioner, S., Hobbs, D., Bombrun, A., Michalik, D., Ramos-Lerate, M., Butkevich, A., Comoretto, G., Joliet, E., Holl, B., Hutton, A., Parsons, P., Steidelmüller, H., Abbas, U., Altmann, M., Andrei, A., Anton, S., Bach, N., Barache, C., Becciani, U., Berthier, J., Bianchi, L., Biermann, M., Bouquillon, S., Bourda, G., Brüsemeister, T., Bucciarelli, B., Busonero, D., Carlucci, T., Castañeda, J., Charlot, P., Clotet, M., Crosta, M., Davidson, M., de Felice, F., Drimmel, R., Fabricius, C., Fienga, A., Figueras, F., Fraile, E., Gai, M., Garralda, N., Geyer, R., González-Vidal, J. J., Guerra, R., Hambly, N. C., Hauser, M., Jordan, S., Lattanzi, M. G., Lenhardt, H., Liao, S., Löffler, W., McMillan, P. J., Mignard, F., Mora, A., Morbidelli, R., Portell, J., Riva, A., Sarasso, M., Serraller, I., Siddiqui, H., Smart, R., Spagna, A., Stampa, U., Steele, I., Taris, F., Torra, J., van Reeven, W., Vecchiato, A., Zschocke, S., de Bruijne, J., Gracia, G., Raison, F., Lister, T., Marchant, J., Messineo, R., Soffel, M., Osorio, J., de Torres, A., and O'Mullane, W.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Gaia Data Release 1 (Gaia DR1) contains astrometric results for more than 1 billion stars brighter than magnitude 20.7 based on observations collected by the Gaia satellite during the first 14 months of its operational phase. We give a brief overview of the astrometric content of the data release and of the model assumptions, data processing, and validation of the results. For stars in common with the Hipparcos and Tycho-2 catalogues, complete astrometric single-star solutions are obtained by incorporating positional information from the earlier catalogues. For other stars only their positions are obtained by neglecting their proper motions and parallaxes. The results are validated by an analysis of the residuals, through special validation runs, and by comparison with external data. Results. For about two million of the brighter stars (down to magnitude ~11.5) we obtain positions, parallaxes, and proper motions to Hipparcos-type precision or better. For these stars, systematic errors depending e.g. on position and colour are at a level of 0.3 milliarcsecond (mas). For the remaining stars we obtain positions at epoch J2015.0 accurate to ~10 mas. Positions and proper motions are given in a reference frame that is aligned with the International Celestial Reference Frame (ICRF) to better than 0.1 mas at epoch J2015.0, and non-rotating with respect to ICRF to within 0.03 mas/yr. The Hipparcos reference frame is found to rotate with respect to the Gaia DR1 frame at a rate of 0.24 mas/yr. Based on less than a quarter of the nominal mission length and on very provisional and incomplete calibrations, the quality and completeness of the astrometric data in Gaia DR1 are far from what is expected for the final mission products. The results nevertheless represent a huge improvement in the available fundamental stellar data and practical definition of the optical reference frame., Comment: Accepted for publication in Astronomy & Astrophysics

Published
2016
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17. VHEE CONVENTIONAL AND FLASH TREATMENT PLANNING: THE CASE OF CHORDOMA AND MENINGIOMA LESIONS

Author

Muscato, A., primary, Battistoni, G., additional, Campana, L., additional, Carlotti, D., additional, De Felice, F., additional, De Gregorio, A., additional, De Simoni, M., additional, Di Felice, C., additional, Dong, Y., additional, Fischetti, M., additional, Franciosini, G., additional, Marafini, M., additional, Mattei, I., additional, Mirabelli, R., additional, Muraro, S., additional, Pacilio, M., additional, Palumbo, L., additional, Patera, V., additional, Schiavi, A., additional, Sciubba, A., additional, Schwarz, M., additional, Sorbino, S., additional, Tombolini, V., additional, Toppi, M., additional, Traini, G., additional, Trigilio, A., additional, and Sarti, A., additional

Published
2023
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18. Strains and Jets in Black Hole Fields

Author

Bini, D., de Felice, F., and Geralico, A.

Subjects
General Relativity and Quantum Cosmology
Abstract

We study the behaviour of an initially spherical bunch of particles emitted along trajectories parallel to the symmetry axis of a Kerr black hole. We show that, under suitable conditions, curvature and inertial strains compete to generate jet-like structures., Comment: To appear in the Proceedings of the Spanish Relativity Meeting 2007 held in Tenerife (Spain) 3 Figures

Published
2007
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19. Naked Singularities, Cosmic Time Machines and Impulsive Events

Author

de Felice, F.

Subjects
General Relativity and Quantum Cosmology
Abstract

Continued gravitational collapse gives rise to curvature singularities. If a curvature singularity is globally naked then the space-time may be causally future ill-behaved admitting closed time-like or null curves which extend to asymptotic distances and generate a Cosmic Time Machine (de Felice (1995) Lecture Notes in Physics 455, 99). The conjecture that Cosmic Time Machines give rise to high energy impulsive events is here considered in more details., Comment: 15 pages, 2 figures

Published
2007
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25. A General Relativistic Model of Light Propagation in the Gravitational Field of the Solar System: the Static Case

Author

de Felice, F., Crosta, M. T., Vecchiato, A., Lattanzi, M. G., and Bucciarelli, B.

Subjects
Astrophysics
Abstract

We develop here a new approach for the relativistic modeling of the photons moving into a quasi-Minkowskian space-time, where the metric is generated by an arbitrary n-body distribution within an isolated Solar System. Our model is built on the prescriptions of the theory of General Relativity and leaves the choices of the metric, as well as that of the motion of the observer, arbitrary. Adopting a quasi-Minkowskian expression of the metric accurate to order (v/c)^2, a thorough numerical test campaign is conducted to verify correctness and reliability of the model equations. The test results show that the model behaves according to predictions. Specifically, comparisons to true (simulated) data demonstrate that stellar distances are reconstructed up to the specified level of accuracy. Although the (v/c)^2 approximation is not always sufficient for its application to future astrometric experiments, which require modeling to (v/c)^3, this work serves also as a natural test-ground for the higher order model, whose formulation is now close to completion, and will be presented in a forthcoming paper., Comment: 60 pages, 15 figures. Accepted by ApJ

Published
2004
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27. Jet dynamics in black hole physics: acceleration during subparsec collimation

Author

de Felice, F. and Zanotti, O.

Subjects
Astrophysics, General Relativity and Quantum Cosmology
Abstract

We study the processes of particle acceleration which take place in the field of a rotating black hole as part of a mechanism of formation of galactic jets within the first parsec from the central source, where gravitation is supposed to be dominant. We find the Lorentz factor that a stream of particles acquires as function of distance, when the orbital parameters vary slightly due to a local electromagnetic field or a pressure gradient., Comment: 39 pages, 14 figures, accepted for publication on the General Relativity and Gravitation

Published
1999
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28. Black holes in sources with a periodic component of variability

Author

Karas, V., Semerak, O., and de Felice, F.

Subjects
Astrophysics
Abstract

Three recent papers have been collected here, discussing the possibility and properties of periodic modulation of a signal from accreting black holes surrounded by orbiting clumps of gas., Comment: 19 pages, 7 figures; LaTeX2.09, contains a collection of three related preprints, to appear in PASJ and ApJ

Published
1999

29. Treatment planning of intracranial lesions with VHEE: comparing conventional and FLASH irradiation potential with state-of-the-art photon and proton radiotherapy

Author

Muscato, A., primary, Arsini, L., additional, Battistoni, G., additional, Campana, L., additional, Carlotti, D., additional, De Felice, F., additional, De Gregorio, A., additional, De Simoni, M., additional, Di Felice, C., additional, Dong, Y., additional, Franciosini, G., additional, Marafini, M., additional, Mattei, I., additional, Mirabelli, R., additional, Muraro, S., additional, Pacilio, M., additional, Palumbo, L., additional, Patera, V., additional, Schiavi, A., additional, Sciubba, A., additional, Schwarz, M., additional, Sorbino, S., additional, Tombolini, V., additional, Toppi, M., additional, Traini, G., additional, Trigilio, A., additional, and Sarti, A., additional

Published
2023
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31. A method to determine the parameters of black holes in AGNs and galactic X-ray sources with periodic modulation of variability

Author

Semerak, O., de Felice, F., and Karas, V.

Subjects
Astrophysics
Abstract

We propose a simple and unambiguous way to deduce the parameters of black holes which may reside in AGNs and some types of X-ray binaries. The black-hole mass and angular momentum are determined in physical units. The method is applicable to the sources with periodic components of variability, provided one can assume the following: (i) Variability is due to a star or a stellar-mass compact object orbiting the central black hole and passing periodically through an equatorial accretion disk (variability time-scale is given by the orbital period). (ii) The star orbits almost freely, deviation of its trajectory due to passages through the disk being very weak (secular); the effect of the star on the disk, on the other hand, is strong enough to yield observable photometric and spectroscopic features. (iii) The gravitational field within the nucleus is that of the (Kerr) black hole, the star and the disk contribute negligibly., Comment: 17 pages, 4 figures, 2 tables; LaTeX2.09 (aas2pp4.sty); submitted to the Astrophysical Journal; also available at http://astro.mff.cuni.cz/karas/papers.htm with additional illustrations

Published
1998
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32. An Anisotropic Wormhole:TUNNELLING in Time and Space

Author

de Alfaro, M. Cavaglia' V. and de Felice, F.

Subjects
General Relativity and Quantum Cosmology
Abstract

We discuss the structure of a gravitational euclidean instanton obtained through coupling of gravity to electromagnetism. Its topology at fixed $t$ is $S^1\times S^2$. This euclidean solution can be interpreted as a tunnelling to a hyperbolic space (baby universe) at $t=0$ or alternatively as a static wormhole that joins the two asymptotically flat spaces of a Reissner--Nordstr\"om type solution with $M=0$., Comment: PLAIN-TEX, 16 pages (4 figures not included), Report DFTT 2/93

Published
1993
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33. MO-0477 Potential of Very High Energy Electron (FLASH) beams in pancreatic and head-and-neck treatments

Author

Muscato, A., primary, Arsini, L., additional, Campana, L., additional, Carlotti, D., additional, De Gregorio, A., additional, De Felice, F., additional, Di Felice, C., additional, Fischetti, M., additional, Fiore, M., additional, Franciosini, G., additional, Marafini, M., additional, Marè, V., additional, Mattei, I., additional, Pacilio, M., additional, Patera, V., additional, Ramella, S., additional, Schiavi, A., additional, Sciubba, A., additional, Schwarz, M., additional, Toppi, M., additional, Traini, G., additional, Trigilio, A., additional, and Sarti, A., additional

Published
2023
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34. PO-1193 Pattern of practice in elderly patients with HPV positive oropharyngeal cancer: a multicenter study

Author

Bonomo, P., primary, Romei, A., additional, Salvestrini, V., additional, Doccioli, C., additional, Belgioia, L., additional, Maddalo, M., additional, Fanetti, G., additional, De Franco, P., additional, Bertocci, S., additional, De Felice, F., additional, Ursino, S., additional, Merlotti, A., additional, Alterio, D., additional, Iacovelli, A.N., additional, Miccichè, F., additional, D'Angelo, E., additional, Becherini, C., additional, Desideri, I., additional, Caini, S., additional, and Livi, L., additional

Published
2023
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36. PO-1401 Elderly Anal Cancer Patients Treated With Intensity-Modulated Radiation Therapy: A Multicenter Study

Author

Caravatta, L., primary, Mantello, G., additional, Valvo, F., additional, Franco, P., additional, Gasparini, L., additional, Di Guglielmo, F.C., additional, Slim, N., additional, Manfrida, S., additional, Gambacorta, M.A., additional, De Felice, F., additional, Gerardi, M.A., additional, Vagge, S., additional, Krengli, M., additional, Palazzari, E., additional, Osti, M.F., additional, Gonnelli, A., additional, Catalano, G., additional, Pittoni, P., additional, Ivaldi, G.B., additional, Galardi, A., additional, Lupattelli, M., additional, Rosetto, M.E., additional, Niespolo, R.M., additional, Guido, A., additional, Durante, O., additional, Macchia, G., additional, Munoz, F., additional, Khouzai, B.E., additional, Lucido, M.R., additional, D'Angelillo, R.M., additional, Porreca, A., additional, Di Nicola, M., additional, and Genovesi, D., additional

Published
2023
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38. Transvaginal ultrasound-guided biopsy in patients with suspicious primary advanced tubo-ovarian carcinoma

Author

Mascilini, F., Quagliozzi, L., Mirandola, M., Moro, Francesca, D'Alessandris, N., De Felice, F., Testa, Antonia Carla, Scambia, Giovanni, Fagotti, Anna, Moro F., Testa A. C. (ORCID:0000-0003-2217-8726), Scambia G. (ORCID:0000-0003-2758-1063), Fagotti A. (ORCID:0000-0001-5579-335X), Mascilini, F., Quagliozzi, L., Mirandola, M., Moro, Francesca, D'Alessandris, N., De Felice, F., Testa, Antonia Carla, Scambia, Giovanni, Fagotti, Anna, Moro F., Testa A. C. (ORCID:0000-0003-2217-8726), Scambia G. (ORCID:0000-0003-2758-1063), and Fagotti A. (ORCID:0000-0001-5579-335X)

Abstract

Objective To assess the accuracy of pathological diagnosis by transvaginal ultrasound-guided biopsy versus surgery in patients with suspicious primary advanced tubo-ovarian carcinoma. The Feasibility, adequacy, and safety of the procedure were also evaluated. Methods Consecutive women with pre-operative suspicious primary advanced tubo-ovarian carcinoma presenting between July 2019 and September 2021 were enrolled. Accuracy was calculated including only cases who underwent surgery. Feasibility was defined as the number of cases in which ultrasound-guided biopsy was possible according to tumor characteristics (morphology and site). Adequacy was defined as the number of conclusive diagnoses out of the samples collected. Safety was defined by the number of major complications which were defined as hospitalization, surgery, and/or blood transfusion. Results A total of 278 patients were eligible for the study; 158 were enrolled, while 120 were excluded for logistic reasons or patient refusal. Ultrasound-guided biopsy was not feasible in 30 (19%) patients. The samples obtained in the remaining 128 patients were all adequate (100%), and no major complications were noted. A total of 26 (20%) patients started neoadjuvant chemotherapy on the basis of the diagnosis obtained by ultrasound, whereas 102 (80%) patients underwent surgery. Accuracy of ultrasound-guided biopsy versus surgery was 94% (96/102), with six false negative cases at ultrasound (6%). Site (prevesical peritoneum) and size (<8 mm) of the nodules resulted as major predictive factors for ultrasound-guided biopsy failure (false negative). Ultrasound-guided biopsy correctly identified 86 primary invasive tubo-ovarian carcinomas and 10 metastatic tumors. Conclusion Ultrasound-guided biopsy is a feasible, safe, and accurate method to provide histological diagnosis in suspicious advanced tubo-ovarian cancer patients.

Published
2023

44. CO-02.2 - VHEE CONVENTIONAL AND FLASH TREATMENT PLANNING: THE CASE OF CHORDOMA AND MENINGIOMA LESIONS

Author

Muscato, A., Battistoni, G., Campana, L., Carlotti, D., De Felice, F., De Gregorio, A., De Simoni, M., Di Felice, C., Dong, Y., Fischetti, M., Franciosini, G., Marafini, M., Mattei, I., Mirabelli, R., Muraro, S., Pacilio, M., Palumbo, L., Patera, V., Schiavi, A., Sciubba, A., Schwarz, M., Sorbino, S., Tombolini, V., Toppi, M., Traini, G., Trigilio, A., and Sarti, A.

Published
2023
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47. Quality of life and sexual functioning among endometrial cancer patients treated with one week adjuvant high-dose-rate vaginal brachytherapy schedule

Author

Facondo, G., Vullo, G., De Sanctis, V., Vitiello, C., Nieddu, L., Alfo', M., Scaringi, C., De Felice, F., Rotondi, M., De Giacomo, F., Ruscito, I., Valeriani, M., and Osti, M. F.

Subjects
quality of life, Oncology, brachytherapy, endometrial carcinoma, fatigue, Radiology, Nuclear Medicine and imaging, sexual disfunction
Abstract

To examine quality of life (QOL) and sexual functioning in a series of patients with intermediate- and high-intermediate risk endometrial cancer, treated with exclusive adjuvant one week high-dose-rate (HDR) vaginal brachytherapy (VBT) schedule.Between July 2008 and October 2013, 55 patients with diagnosis of endometrial cancer were treated with adjuvant exclusive VBT. All patients had undergone surgical treatment with a laparotomy approach before VBT. Post-operative VBT was administered 6-8 weeks after surgery. Treatment was delivered to vaginal vault using Nucletron HDR unit with iridium-192 source at a dose of 21 Gy/3 fractions of 7 Gy each, three times a week, every other day, prescribed at 0.5 cm depth of vaginal wall, and 3 cm in length from the apex. QOL was assessed using European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire Core-30 (QLQ-C30), and EORTC cancer-specific quality of life questionnaire (QLQ-CX24).Median follow-up time was 92 months (range, 42-162 months). Questionnaires were carried out respectively at 1, 3, 6, 12, 24, 36, 48, and 60 months after the end of BT. Response rate to questionnaires was 100% (One week brachytherapy schedule to vaginal cuff is generally well-tolerated. QOL does not worsen after applying vaginal brachytherapy.

Published
2022
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49. MT39 Factors Influencing the Uptake of Magnetic Resonance Imaging-Guided High Intensity Focused Ultrasound for Painful Bone Metastases in Europe: A Group Concept Mapping Study

Author

Galendi, J, primary, Siefen, AC, additional, Moretti, D, additional, Yeo, SY, additional, Bratke, G, additional, Grüll, H, additional, Morganti, AG, additional, Gasperini, C, additional, Bazzocchi, A, additional, De Felice, F, additional, Blanco, R, additional, Huhtala, M, additional, Nijholt, I, additional, Boomsma, MF, additional, Bos, C, additional, Verkooijen, HM, additional, Müller, D, additional, and Stock, S, additional

Published
2022
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