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179 results on '"DE FELICE, L"'

2. Optimal strategies for the decumulation of retirement savings under differing appetites for liquidity and investment risks

Author

Avanzi, B, De Felice, L, Avanzi, B, and De Felice, L

Abstract

A retiree’s appetite for risk is a common input into the lifetime utility models that are traditionally used to find optimal strategies for the decumulation of retirement savings. In this work, we consider a retiree with potentially differing appetites for the key financial risks of decumulation: liquidity risk and investment risk. We set out to determine whether these differing risk appetites have a significant impact on the retiree’s optimal choice of decumulation strategy. To do so, we design and implement a framework which selects the optimal decumulation strategy from a general set of admissible strategies in line with a retiree’s goals, and under differing appetites for the key risks of decumulation. Overall, we find significant evidence to suggest that a retiree’s differing appetites for different decumulation risks will impact their optimal choice of strategy at retirement. Through an illustrative example calibrated to the Australian context, we find results which are consistent with actual behaviours in this jurisdiction (in particular, a shallow market for annuities), which lends support to our framework and may provide some new insight into the so-called annuity puzzle.

Published
2024

6. Poor-Risk Acute Myelogenous Leukemia Patients Undergoing the Fludarabine – Cytosine Arabinoside – Filgrastim Regimen: Multidrug Resistance Expression, Granulocyte Colony-Stimulating Factor Priming Activity and Clinical Response

Author

Petti, M. C., Martelli, M. P., Tosti, S., De Felice, L., Valentini, T., Tafuri, A., Petrucci, M. T., Mandelli, F., Büchner, T., editor, Schellong, G., editor, Ritter, J., editor, Creutzig, U., editor, Hiddemann, W., editor, and Wörmann, B., editor

Published
1997
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21. Living Planet Report 2018: Aiming Higher

Author

Barrett, M., Belward, A., Bladen, S, Breeze, T., Burgess, N., Butchart, S., Clewclow, H., Cornell, S., Cottam, A., Croft, S., de Carlo, G., de Felice, L., de Palma, A., Deinet, S., Downie, R., Drijver, C., Fischler, B., Freeman, R., Gaffney, O., Galli, A, Gamblin, P., Garratt, M., Gorelick, N., Green, J., Grooten, M., Hanscom, L., Hill, S., Hilton-Taylor, C., Jones, A., Juniper, T., Khan, H., Kroodsma, D., Leclere, D., Llewellyn, G., Mace, G., McRae, L., Mo, K., Opperman, J., Orgiazzi, A., Orr, S., Pacheco, P., Palomares, D., Pauly, D., Pekel, J.-F., Pendleton, L., Purvis, A., Radcliffe, N., Roxburgh, T., Scholes, B, Senapathi, D., Tanzer, D., Thieme, M., Tickner, D., Tittonell, P., Trathan, P., Visconti, P., Wackernagel, M., West, C., Zwaal, N., Barrett, M., Belward, A., Bladen, S, Breeze, T., Burgess, N., Butchart, S., Clewclow, H., Cornell, S., Cottam, A., Croft, S., de Carlo, G., de Felice, L., de Palma, A., Deinet, S., Downie, R., Drijver, C., Fischler, B., Freeman, R., Gaffney, O., Galli, A, Gamblin, P., Garratt, M., Gorelick, N., Green, J., Grooten, M., Hanscom, L., Hill, S., Hilton-Taylor, C., Jones, A., Juniper, T., Khan, H., Kroodsma, D., Leclere, D., Llewellyn, G., Mace, G., McRae, L., Mo, K., Opperman, J., Orgiazzi, A., Orr, S., Pacheco, P., Palomares, D., Pauly, D., Pekel, J.-F., Pendleton, L., Purvis, A., Radcliffe, N., Roxburgh, T., Scholes, B, Senapathi, D., Tanzer, D., Thieme, M., Tickner, D., Tittonell, P., Trathan, P., Visconti, P., Wackernagel, M., West, C., and Zwaal, N.

Published
2018

22. Impact of nucleic acid testing for hepatitis B virus, hepatitis C virus, and human immunodeficiency virus on the safety of blood supply in Italy: a 6-year survey

Author

Claudio, Velati, Luisa, Romano, Laura, Fomiatti, Lorella, Baruffi, Alessandro Remo Zanetti, Research Group: Sciariada, Simti L., Lobbiani, L., Prati, D., Marconi, M., Ravagnani, E., Rossi, E., Rossini, S., Bellavita, P., Moroni, G. A., Bodini, U., Pagliaro, P., Azzario, F., Rossi, D., Sciorelli, G., Salvaneschi, L., Cambie, G., Marini, M., Pizzoccolo, G., Gazzola, G. B., Peres, E., Mariottini, C., Graziani, G., Baicchi, U., Palla, P., Vacri, L., Strada, P., Miceli, M., Iudicone, P., Girelli, Gabriella, Ursitti, A., De Silvestro, G., Gentile, R., Di Paola, P., Manca, M., Martinelli, L., Bonomo, P., Calabrese, S., Pistolese, G., Aprili, G., Bressan, F., Ripamonti, M., Catalano, A., Gallerano, P., Giacalone, I., Fiorilla, A., Giannotti, G., Cantella, R., Di Persia, M. G., Esposito, V., Sardella, C., Di Monte, D., Bajorek, M., Reina, A., Silvani, C. M., Piani, M., Salvoni, G., De Felice, L., Macri, M., De Palma, M., Vecchi, C., Belloni, M., Bettini, C., Ghiazza, P., De Santis, D., Di Mauro, L., Antoncecchi, S., Rinaldi, C., Allegreita, G., Siracusano, L., Adami, R., Lanteri, M., Mazzei, C., Tagariello, G., Gajo, G. B., Berti, P., Giordano, C., Palazzesi, G., Del Gusto, B., Pavone, A., Vacchini, M., Tomasini, A., Vaselli, G., Fiorin, F., Bresolin, G., Bertola, F., Testa, D., Semino, G., Tomasini, I., Zucchelli, P., Chicchi, R., Peano, G., Franchi, D., Sabelli, M., Miloro, G., Di Gregorio, P., Reimondo, P., Cimino, G., Tripodi, G., Borzini, P., Tarditi, M., Cocchi, T., Pata, V., Santarelli, R., Geremicca, W., Minerva, A., Maccarione, F. P., Solanda, F., Rivasi, P., Carubia, F., Prinoth, O., Ostuni, A., Bossio, M., Maggiotto, A., Valentino, F., Puzzonia, P., and Source Musto, C.

Subjects
Adult, Male, Hepatitis B virus, Genotype, Hepacivirus, Hepatitis C virus, Immunology, Blood Donors, HIV Infections, medicine.disease_cause, Virus, Flaviviridae, Orthohepadnavirus, Risk Factors, Seroepidemiologic Studies, medicine, Humans, Mass Screening, Immunology and Allergy, Aged, biology, business.industry, HIV, virus diseases, Hematology, Middle Aged, Hepatitis B, biology.organism_classification, medicine.disease, Hepatitis C, Virology, digestive system diseases, Italy, Hepadnaviridae, Virus Diseases, Health Care Surveys, Blood Banks, Female, Morbidity, Safety, business, Risk Reduction Behavior
Abstract

BACKGROUND: Nucleic acid testing (NAT) for hepatitis C virus (HCV) and human immunodeficiency virus (HIV) has been implemented in several European countries and in the United States, while hepatitis B virus (HBV) NAT is still being questioned by opinions both in favor and against such an option, depending on the HBV endemicity, health care resources, and expected benefits. STUDY DESIGN AND METHODS: This survey was aimed to assess the NAT impact in improving the safety of blood supply in Italy, 6 years after implementation. The study involved 93 Italian transfusion centers and was carried out in 2001 through 2006. A total of 10,776,288 units were tested for the presence of HCV RNA, 7,932,430 for HIV RNA, and 3,405,497 for HBV DNA, respectively. RESULTS: Twenty-seven donations or 2.5 per million tested were HCV RNA–positive/anti-HCV–negative; 14 or 1.8 per million units tested were HIV RNA–positive/anti-HIV–negative; and 197 or 57.8 per million donations tested were HBV DNA–positive/hepatitis B surface antigen–negative. Of the latter, 8 (2.3/106) were collected from donors in the window phase of infection and 189 (55.5/106) from donors with occult HBV. Sixty-eight percent of the latter donors had hepatitis B surface antibody, 74.5 percent of whom with concentrations considered protective (≥10 mIU/mL). CONCLUSION: NAT implementation has improved blood safety by reducing the risk of entering 2.5 HCV and 1.8 HIV infectious units per million donations into the blood supply. The yield of NAT in detecting infectious blood before transfusion was higher for HBV than for HCV or HIV. However, the benefit of HBV NAT in terms of avoided HBV-related morbidity and mortality in blood recipients needs to be further evaluated.

Published
2008

36. Flt3LP3nduces the ex-vivo amplification of umbilical cord blood committed progenitors and early stem cells in short-term cultures

Author

De Felice, L, Di Pucchio, T, Mascolo, M, Agostini, F, Breccia, M, Guglielmi, C, Ricciardi, M, Tafuri, A, Screnci, M, Mandelli, F, and Arcese, W

Subjects
Cultured, Cells, Infant, Newborn, Infant, Receptor Protein-Tyrosine Kinases, Antigens, CD34, Newborn, Fetal Blood, Flow Cytometry, Hematopoietic Stem Cells, Proto-Oncogene Proteins, Cells, Cultured, Humans, fms-Like Tyrosine Kinase 3, Immunophenotyping, CD34, Antigens, Settore MED/15 - Malattie del Sangue
Abstract

Umbilical cord blood (UCB) has been successfully used for haemopoietic stem cell transplantation, although its use has been cautiously limited to paediatric patients because of the reduced volume produced. The clinical results have confirmed that either engraftment or survival significantly correlate with cell dose infused. We have standardized a culture method providing in a short time a significant amplification of both committed progenitors and primitive stem cells for clinical use. Eight-day culture of UCB cells with flt3L/SCF/PIXY 321 induced a 10-fold amplification of CD34+ cells and the expansion of multipotent (CFU-GEMM) and committed (CFU-GM, BFU-E) progenitors respectively of 5-, 7- and 9-fold over input cells. As to the early stem cell pool, the primitive CD34+Thy-1+ cell fraction increased 6-fold and the LTC-IC were amplified 17-fold. Furthermore, the in vitro proliferation was detected by the gradual loss of fluorescence of the CD34+ cells tracked at day 0 with the dye PKH26. After 8 d of amplification6% of the CD34+ cells remained intensely fluorescent. This subpopulation represents a deeply quiescent cell fraction unresponsive to cytokines and very enriched of primitive stem cells. These cells are most likely to be responsible for long-term reconstitution after transplant.

Published
1999

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