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2. Mapping QTLs for grain yiellow pigment content in the cultivated durum wheat germplasm

Author

MACCAFERRI, MARCO, CORNETI, SIMONA, FRANCIA, ROSSELLA, TUBEROSA, ROBERTO, SANGUINETI, MARIA CORINNA, DEMONTIS A., MASSI A., DE AMBROGIO E., JURMAN I., MORGANTE M., AMMAR K., MACCAFERRI M., CORNETI S., FRANCIA R., DEMONTIS A., MASSI A., DE AMBROGIO E., JURMAN I., MORGANTE M., AMMAR K., TUBEROSA R., and SANGUINETI M.C.

Published
2009

3. Identification of QTLs for grain yield in durum wheat grown cross a broad range of Mediterranean environments

Author

MACCAFERRI, MARCO, SANGUINETI, MARIA CORINNA, STEFANELLI, SANDRA, TUBEROSA, ROBERTO, ARAUS ORTEGA J. L., BEN SALEM M., BORT J., DE AMBROGIO E., DEL MORAL G. L. F., DE MONTIS A., EL AHMED A., MAALOUF F., MACHLAB H., MARTOS V., MOTAWAI J., NACHIT M., NSERALLAH N., OUABBOU H., ROYO C., SLAMA A., VILLEGAS D., MACCAFERRI M., SANGUINETI M.C., STEFANELLI S., ARAUS ORTEGA J.L., BEN SALEM M., BORT J., DE AMBROGIO E., DEL MORAL G.L.F., DE MONTIS A., EL-AHMED A., MAALOUF F., MACHLAB H., MARTOS V., MOTAWAI J., NACHIT M., NSERALLAH N., OUABBOU H., ROYO C., SLAMA A., VILLEGAS D., and TUBEROSA R.

Published
2009

4. Searching for QTLs for adaptation to reduced water and nitrogen inputs in durum wheat

Author

MACCAFERRI, MARCO, SANGUINETI, MARIA CORINNA, CORNETI, SIMONA, STEFANELLI, SANDRA, TUBEROSA, ROBERTO, AMMAR K., DE AMBROGIO E., DEMONTIS A., MASSI A., REYNOLDS M., ORTIZ MONASTERI I., MACCAFERRI M., SANGUINETI M.C., AMMAR K., DE AMBROGIO E., DEMONTIS A., MASSI A., REYNOLDS M., ORTIZ-MONASTERI I., CORNETI S., STEFANELLI S., and TUBEROSA R.

Published
2008

5. QTLs for yield and adaptation to reduced water and nitrogen inputs in durum wheat

Author

MACCAFERRI, MARCO, SANGUINETI, MARIA CORINNA, CORNETI, SIMONA, STEFANELLI, SANDRA, TUBEROSA, ROBERTO, AMMAR K., DEMONTIS A., DE AMBROGIO E., MASSI A., ORTIZ MONASTERIO I., REYNOLDS M., APPEL R., EASTWOOD R., LAGUDAH E., LANGRIDGE P., MACKAY M., MCINTYRE L., SHARP P., MACCAFERRI M., SANGUINETI M.C., AMMAR K., DEMONTIS A., DE AMBROGIO E., MASSI A., ORTIZ-MONASTERIO I., REYNOLDS M., CORNETI S., STEFANELLI S., and TUBEROSA R.

Subjects
food and beverages
Abstract

A population of 181 recombinant inbred lines (RILs) derived from the cross Meridiano × Claudio was evaluated in five field trials varying for water and nitrogen regimes. A preliminary analysis carried out with 213 SSR and DArT markers evidenced two major QTL clusters for grain yield, yield components and several other traits on chrs. 4B and 5A. Favourable alleles were inherited from the parental cultivar Claudio at the 4B QTL region and from Meridiano at the 5A QTL. Additional markers with highly significant effects on grain yield were found on chrs. 2B, 3B, 5B and 7B, with favourable alleles contributed by both parents, thus accounting for the wide transgressive segregation observed among the RILs. Grain yield of the RILs was highly predictable based on the SSR alleles present at four key-chromosome regions.

Published
2008

6. Two QTL clusters on chromosomes 2BL and 3BS influence grain yield and other morpho-physiological traits in durum wheat across a broad range of Mediterranean environments

Author

MACCAFERRI, MARCO, SANGUINETI, MARIA CORINNA, STEFANELLI, SANDRA, ARAUS J. L., BEN SALEM M., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L. F., DEMONTIS A., EL AHMED A., MAALOUF F., MACHLAB V., MARTOS V., MOTAWAI J., NACHIT M. M., NSERALLAH N., OUABBOU H., ROYO C., SLAMA A., VILLEGAS D., MACCAFERRI M., SANGUINETI M.C., STEFANELLI S., ARAUS J.L., BEN SALEM M., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L.F., DEMONTIS A., EL-AHMED A., MAALOUF F., MACHLAB V., MARTOS V., MOTAWAI J., NACHIT M.M., NSERALLAH N., OUABBOU H., ROYO C., SLAMA A., and VILLEGAS D.

Published
2008

8. A four-parental map suitable for multi-allelic QTL discovery in durum wheat

Author

GIULIANI, SILVIA, MACCAFERRI, MARCO, MASSI A., DE AMBROGIO E., TREBBI D., LENSINK D., PELEMAN J. D., SØRENSEN A. P., GIULIANI S., MACCAFERRI M., MASSI A., DE AMBROGIO E., TREBBI D., LENSINK D., PELEMAN J.D., and SØRENSEN A.P.

Subjects
multiparental mapping population, wheat, genetic mapping, SNP
Published
2008

9. Two epistatic QTLs on chromosomes 2BL and 3BS influence grain yield of durum wheat across a broad range of water regimes

Author

MACCAFERRI, MARCO, SANGUINETI, MARIA CORINNA, CORNETI, SIMONA, STEFANELLI, SANDRA, CONTI, SERGIO, TUBEROSA, ROBERTO, ARAUS ORTEGA J. L., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L. F., DEMONTIS A., EL AHMED A., MAALOUF F., MACHLAB H., MARTOS V., MORAGUES M., MOTAWAJ J., NACHIT M., NSARELLAH N., OUABBOU H., ROYO C., SLAMA A., MACCAFERRI M., SANGUINETI M.C., CORNETI S., STEFANELLI S., ARAUS ORTEGA J.L., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L.F., DEMONTIS A., EL-AHMED A., MAALOUF F., MACHLAB H., MARTOS V., MORAGUES M., MOTAWAJ J., NACHIT M., NSARELLAH N., OUABBOU H., ROYO C., SLAMA A., CONTI S., and TUBEROSA R.

Published
2008

10. Genome-wide association mapping in durum wheat

Author

MACCAFERRI, MARCO, SANGUINETI, MARIA CORINNA, CORNETI, SIMONA, STEFANELLI, SANDRA, TUBEROSA, ROBERTO, ARAUS ORTEGA J. L., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L. F., DEMONTIS A., EL AHMED A., MAALOUF F., MACHLAB H., MARTOS V., MORAGUES M., MOTAWAJ J., NACHIT M., NSARELLAH N., OUABBOU H., ROYO C., SLAMA A., MACCAFERRI M., SANGUINETI M.C., CORNETI S., STEFANELLI S., ARAUS ORTEGA J.L., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L.F., DEMONTIS A., EL-AHMED A., MAALOUF F., MACHLAB H., MARTOS V., MORAGUES M., MOTAWAJ J., NACHIT M., NSARELLAH N., OUABBOU H., ROYO C., SLAMA A., and TUBEROSA R.

Published
2008

12. Durum wheat germplasm variability for adaptation to rainfed Mediterranean environments

Author

MACCAFERRI, MARCO, SANGUINETI, MARIA CORINNA, STEFANELLI, SANDRA, TUBEROSA, ROBERTO, ARAUS ORTEGA J. L., BEN SALEM M., BORT J., CHENENAOUI S., DE AMBROGIO E., DE MONTIS A., EL AHMED A., ELOUAFI I., GARCIA DEL MORAL L. F., MAALOUF F., MACHLAB H., NACHIT M. M., NATOLI V., NSERALLAH N., OUABBOU H., RHARRABTI Y., RHOUMA A., ROYO C., VILLEGAS D., JURMAN J., OLIVIERI A., MORGANTE M., MACCAFERRI M., SANGUINETI M.C., ARAUS ORTEGA J.L., BEN SALEM M., BORT J., CHENENAOUI S., DE AMBROGIO E., DE MONTIS A., EL-AHMED A., ELOUAFI I., GARCIA DEL MORAL L.F., MAALOUF F., MACHLAB H., NACHIT M.M., NATOLI V., NSERALLAH N., OUABBOU H., RHARRABTI Y., RHOUMA A., ROYO C., STEFANELLI S., VILLEGAS D., JURMAN J., OLIVIERI A., MORGANTE M., and TUBEROSA R.

Published
2006

13. IDuWUE: Improving Durum wheat for Water-Use Efficiency and yield stability through physiological amd molecular approaches

Author

MACCAFERRI, MARCO, SANGUINETI, MARIA CORINNA, TUBEROSA, ROBERTO, NATOLI V., ARAUS ORTEGA J. L., BEN SALEM M., BORT J., DE AMBROGIO E., DE MONTIS A., EL AHMED A., GARCIA DEL MORAL L. F., ISIDRO J., MAALOUF F., MARTOS V., MOTAWAJ J., NACHIT M. M., NSERALLAH N., OUABBOU H., RHOUMA S., ROYO C., SLAMA A., VILLEGAS D., MACCAFERRI M., SANGUINETI M.C., NATOLI V., ARAUS ORTEGA J.L., BEN SALEM M., BORT J., DE AMBROGIO E., DE MONTIS A., EL-AHMED A., GARCIA DEL MORAL L.F., ISIDRO J., MAALOUF F., MARTOS V., MOTAWAJ J., NACHIT M.M., NSERALLAH N., OUABBOU H., RHOUMA S., ROYO C., SLAMA A., VILLEGAS D., and TUBEROSA R.

Published
2006

14. IDuWUE: a EU-funded project for improving water-use efficiency and yield stability in durum wheat

Author

SANGUINETI, MARIA CORINNA, MACCAFERRI, MARCO, TUBEROSA, ROBERTO, NATOLI V., ARAUS ORTEGA J. L., BEN SALEM M., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L. F., DE MONTIS A., EL AHMED A., ELOUAFI I., MAALOUF F., MARTOS V., NACHIT M. M., NSERALLAH N., OUABBOU H., RHARRABTI Y., RHOUMA S., ROYO C., SLAMA A., VILLEGAS D., SANGUINETI M.C., MACCAFERRI M., NATOLI V., ARAUS ORTEGA J.L., BEN SALEM M., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L.F., DE MONTIS A., EL-AHMED A., ELOUAFI I., MAALOUF F., MARTOS V., NACHIT M.M., NSERALLAH N., OUABBOU H., RHARRABTI Y., RHOUMA S., ROYO C., SLAMA A., VILLEGAS D., and TUBEROSA R.

Published
2006

15. QTLs for yield and related traits in a durum wheat RIL population evaluated in the Mediterranean basin under different water availabilities

Author

MACCAFERRI, MARCO, SANGUINETI, MARIA CORINNA, TUBEROSA, ROBERTO, NATOLI V., ARAUS ORTEGA J. L., BEN SALEM M., BORT J., DE AMBROGIO E., DE MONTIS A., EL AHMED A., GARCIA DEL MORAL L. F., ISIDRO J., MAALOUF F., MARTOS V., MOTAWAJ J., NACHIT M. M., NSERALLAH N., OUABBOU H., RHOUMA S., ROYO C., SLAMA A., VILLEGAS D., MACCAFERRI M., SANGUINETI M.C., NATOLI V., ARAUS ORTEGA J.L., BEN SALEM M., BORT J., DE AMBROGIO E., DE MONTIS A., EL-AHMED A., GARCIA DEL MORAL L.F., ISIDRO J., MAALOUF F., MARTOS V., MOTAWAJ J., NACHIT M.M., NSERALLAH N., OUABBOU H., RHOUMA S., ROYO C., SLAMA A., VILLEGAS D., and TUBEROSA R.

Published
2006

17. IDuWUE project. I. Identification of QTLs for drought-related traits in a durum wheat RIL population evaluated in the Mediterranean area under varying water regimes

Author

MACCAFERRI, MARCO, SANGUINETI, MARIA CORINNA, ROTONDO, FRANCESCA, TUBEROSA, ROBERTO, ARAUS J. L., BEN SALEM M., BORT J., DE AMBROGIO E., DEMONTIS A., EL AHMED A., GARCIA DEL MORAL L. F., ISIDRO J., MAALOUF F., MARTOS V., MOTAWAI J., NACHIT M. M., NSERALLAH N., OUABBOU H., RHOUMA S., ROYO C., SLAMA A., VILLEGAS D., MACCAFERRI M., SANGUINETI M.C., ROTONDO F., ARAUS J.L., BEN SALEM M., BORT J., DE AMBROGIO E., DEMONTIS A., EL-AHMED A., GARCIA DEL MORAL L.F., ISIDRO J., MAALOUF F., MARTOS V., MOTAWAI J., NACHIT M.M., NSERALLAH N., OUABBOU H., RHOUMA S., ROYO C., SLAMA A., VILLEGAS D., and TUBEROSA R.

Published
2006

18. Dissection of durable leaf rust resistance in durum wheat

Author

MANTOVANI, PAOLA, MACCAFERRI, MARCO, GIULIANI, SILVIA, SANGUINETI, MARIA CORINNA, TUBEROSA, ROBERTO, MASSI A., DE AMBROGIO E., MANTOVANI P., MACCAFERRI M., GIULIANI S., MASSI A., DE AMBROGIO E., SANGUINETI M.C., and TUBEROSA R.

Published
2006

21. Comparaison of agronomic, morpho-physiological traits and grain yield for a panel of durum and bread wheat under water-limited conditions

Author

BELHAJ FREJ M., CHOUK H., BEN HAJ SALAH H., LATIRI K., HABASH D. Z., PARRY M. A. J., ARAUS J. L., BORT J., NACHIT M., REYNOLDS M., DE AMBROGIO E., TUBEROSA, ROBERTO, SANGUINETI, MARIA CORINNA, BELHAJ FREJ M., CHOUK H., BEN HAJ SALAH H., LATIRI K., HABASH D.Z., PARRY M.A.J., TUBEROSA R., SANGUINETI M.C., ARAUS J.L., BORT J., NACHIT M., REYNOLDS M., and DE AMBROGIO E.

Published
2005

22. IDuWUE: a collaborative EU-funded project for improving water-use efficiency and yield stability in durum wheat

Author

SANGUINETI, MARIA CORINNA, MACCAFERRI, MARCO, GIULIANI, SILVIA, TUBEROSA, ROBERTO, ARAUS ORTEGA J. L., BEN SALEM M., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L. F., DE MONTIS A., EL AHMED A., ELOUAFI L., MAALOUF F., NACHIT M. M., NATOLI V., NSERALLAH N., OUABBOU H., RHARRABTI Y., RHOUMA S., ROYO C., SLAMA A., VILLEGAS D., SANGUINETI M.C., MACCAFERRI M., ARAUS-ORTEGA J.L., BEN SALEM M., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L.F., DE MONTIS A., EL-AHMED A., ELOUAFI L., GIULIANI S., MAALOUF F., NACHIT M.M., NATOLI V., NSERALLAH N., OUABBOU H., RHARRABTI Y., RHOUMA S., ROYO C., SLAMA A., VILLEGAS D., and TUBEROSA R.

Published
2005

23. Improving durum wheat for water use efficiency and yield stability, an EU collaborative project among European and WANA countries

Author

MACCAFERRI, MARCO, SANGUINETI, MARIA CORINNA, STEFANELLI, SANDRA, TUBEROSA, ROBERTO, ARAUS ORTEGA J. L., BEN SALEM M., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L. F., DE MONTIS A., EL AHMED A., ELOUAFI I., MAALOUF F., MACHLAB H., NACHIT M. M., NSERALLAH N., OUABBOU H., RHARRABTI Y., ROYO C., SLAMA A., VILLEGAS D., MACCAFERRI M., SANGUINETI M.C., ARAUS ORTEGA J.L., BEN SALEM M., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L.F., DE MONTIS A., EL-AHMED A., ELOUAFI I., MAALOUF F., MACHLAB H., NACHIT M.M., NSERALLAH N., OUABBOU H., RHARRABTI Y., ROYO C., SLAMA A., STEFANELLI S., VILLEGAS D., and TUBEROSA R.

Published
2005

24. Miglioramento dell'efficienza idrica in frumento duro mediante approcci genomici e fisiologici

Author

MACCAFERRI, MARCO, SANGUINETI, MARIA CORINNA, GIULIANI, SILVIA, TUBEROSA, ROBERTO, ARAUS ORTEGA J. L., BEN SALEM M., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L. F., DE MONTIS A., EL AHMED A., ELOUAFI I., MAALOUF F., NACHIT M. M., NATOLI V., NSERALLAH N., OUABBO H., RHARRABTI Y., ROYO C., SLAMA A., VILLEGAS D., MACCAFERRI M., SANGUINETI M.C., ARAUS-ORTEGA J.L., BEN SALEM M., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L.F., DE MONTIS A., EL-AHMED A., ELOUAFI I., GIULIANI S., MAALOUF F., NACHIT M.M., NATOLI V., NSERALLAH N., OUABBO H., RHARRABTI Y., ROYO C., SLAMA A., VILLEGAS D., and TUBEROSA R.

Published
2005

25. IDuWUE: an EU-funded project for the improvement of water-use efficiency and yield stability in durum wheat

Author

MACCAFERRI, MARCO, SANGUINETI, MARIA CORINNA, GIULIANI, SILVIA, TUBEROSA, ROBERTO, ARAUS ORTEGA J. L., BEN SALEM M., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L. F., DE MONTIS A., EL AHMED A., ELOUAFI I., MAALOUF F., MACHLAB H., NACHIT M. M., NATOLI V., NSERALLAH N., OUABBOU H., RHARRABTI Y., ROYO C., SLAMA A., VILLEGAS D., MACCAFERRI M., SANGUINETI M.C., ARAUS-ORTEGA J.L., BEN SALEM M., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L.F., DE MONTIS A., EL-AHMED A., ELOUAFI I., GIULIANI S., MAALOUF F., MACHLAB H., NACHIT M.M., NATOLI V., NSERALLAH N., OUABBOU H., RHARRABTI Y., ROYO C., SLAMA A., VILLEGAS D., and TUBEROSA R.

Published
2005

26. IDuWUE: a project for the improvement of water-use efficiency and drought tolerance of durum wheat

Author

MACCAFERRI, MARCO, SANGUINETI, MARIA CORINNA, STEFANELLI, SANDRA, GOBBO, RENZO, TUBEROSA, ROBERTO, ARAUS ORTEGA J. L., SALEM M. B., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L. F., DE MONTIS A., EL AHMED A., ELOUAFI I., MAALOUF F., MACHLAB H., NACHIT M. M., NATOLI V., NSERALLAH N., OUABBOU H., RHARRABTI Y., ROYO C., SLAMA A., VILLEGAS D., MACCAFERRI M., SANGUINETI M.C., ARAUS ORTEGA J.L., SALEM M.B., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L.F., DE MONTIS A., EL-AHMED A., ELOUAFI I., STEFANELLI S., GOBBO R., MAALOUF F., MACHLAB H., NACHIT M.M., NATOLI V., NSERALLAH N., OUABBOU H., RHARRABTI Y., ROYO C., SLAMA A., VILLEGAS D., and TUBEROSA R.

Published
2005

27. IDuWUE: a collaborative project for improving durum wheat for water-use efficiency and yield stability

Author

MACCAFERRI, MARCO, SANGUINETI, MARIA CORINNA, GIULIANI, SILVIA, TUBEROSA, ROBERTO, ARAUS ORTEGA J. L., BEN SALEM M., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L. F., DE MONTIS A., EL AHMED A., ELOUAFI I., MAALOUF F., MACHLAB H., MILOUDI NACHIT M., NATOLI E., NSERALLAH N., OUABBOU H., RHARRABTI Y., ROYO C., SLAMA A., VILLEGAS D., MACCAFERRI M., SANGUINETI M.C., ARAUS-ORTEGA J.L., BEN SALEM M., BORT J., DE AMBROGIO E., GARCIA DEL MORAL L.F., DE MONTIS A., EL-AHMED A., ELOUAFI I., GIULIANI S., MAALOUF F., MACHLAB H., MILOUDI NACHIT M., NATOLI E., NSERALLAH N., OUABBOU H., RHARRABTI Y., ROYO C., SLAMA A., VILLEGAS D., and TUBEROSA R.

Published
2005

29. A panel of elite accessions of durum wheat (Triticum durumDesf.) suitable for association mapping studies

Author

Cynda Chenenaoui, Fouad Maalouf, Moncef Ben Salem, Enzo De Ambrogio, H. Machlab, Jihan Motawaj, Luis F. García del Moral, Jordi Bort, Mark Moragues, Maria Corinna Sanguineti, Roberto Tuberosa, Ahmed El-Ahmed, Marco Maccaferri, Andrea De Montis, M. M. Nachit, Conxita Royo, H. Ouabbou, José Luis Araus Ortega, V. Natoli, N. Nserallah, MACCAFERRI M., SANGUINETI M.C., NATOLI V., ARAUS ORTEGA J.L., BEN SALEM M., BORT J., CHENENAOUI C., DE AMBROGIO E., GARCIA DEL MORAL L.F., DE MONTIS A., EL-AHMED A., MAALOUF F., MACHLAB H., MORAGUES M., MOTAWAJ J., NACHIT M.M., NSERALLAH N., OUABBOU H., ROYO C., and TUBEROSA R.

Subjects
Linkage disequilibrium, AFLP, Population structure, durum wheat, Plant Science, Biology, SSR, Centimorgan, Agronomy, Triticum durum, Genetics, Microsatellite, Amplified fragment length polymorphism, Cultivar, Gene pool, association mapping, Association mapping, Agronomy and Crop Science, linkage disequilibrium
Abstract

The effectiveness of association mapping (AM) based on linkage disequilibrium (LD) is currently being tested in a number of crops. An important prerequisite for the application of AM is the availability of collections of accessions with a suitable level of genetic variation for target traits and with limited spurious LD due to the presence of population structure. Herein, the results of a genome-wide molecular characterization of a collection of elite durum wheat accessions well-adapted to Mediterranean environments are presented. Ninety-seven highly polymorphic simple sequence repeats and 166 amplified fragment length polymorphism markers were used to characterize 189 durum accessions, mainly cultivars and advanced breeding lines. Genome-wide significant and sizeable LD indices at a centimorgan scale were observed, while LD mainly decayed within 10 cM. On the other hand, effects due to spurious LD were notably lower than those previously observed in a durum wheat collection sampling durum gene pools of more diverse origin. These results, coupled with the high level of genetic variability detected for a number of important morpho-physiological traits and their high heritability, indicate the suitability of this collection for AM studies targeting agronomically important traits.

Published
2006
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30. Searching for wheat plants with low toxicity in celiac disease: Between direct toxicity and immunologic activation

Author

Francesca Fayer, Lidia Di Prima, Gaetana Di Fede, Vincenzo Villanacci, Norberto Pogna, Giuseppe Ambrosiano, Giuseppe Iacono, Antonio Carroccio, Davide Noto, Enzo De Ambrogio, Domenico Lafiandra, Karen M. Lammers, and Carroccio A, Di Prima L, Noto D, Fayer F, Ambrosiano G, Villanacci V, Lammers K, Lafiandra D, De Ambrogio E, Di Fede G, Iacono G, Pogna N.

Subjects
Settore MED/09 - Medicina Interna, Enterocyte, medicine.medical_treatment, Antibodies, Tissue Culture Techniques, Immunologic activation, Interferon-gamma, medicine, Humans, Intestinal Mucosa, Prolamin, Common wheat, Triticum, Hepatology, biology, Gastroenterology, food and beverages, toxicity, immunologic activation, Interleukin-10, Cytokine, medicine.anatomical_structure, Anti-transglutaminase antibodies, Immunology, Toxicity, biology.protein, Interleukin-2, Antibody, Gene Deletion, wheat plant, celiac disease, Prolamins
Abstract

Background Natural or induced variations in the noxiousness of gluten proteins for celiac disease (CD) patients are currently being investigated for their potential in breeding wheat crops with reduced toxicity. Aims We evaluated the bread wheat line C173 for its effects on the in vitro -grown duodenal mucosa of CD patients. Methods In vitro -grown duodenal mucosa biopsies of 19 CD patients on a gluten-free diet were exposed to peptic/tryptic-digested prolamins from bread wheat line C173 lacking gliadin–glutenin subunits, analyzed for morphology, cytokine and anti-tTG antibody production, and compared with mucosa biopsies exposed to prolamins from wild-type cv. San Pastore. Results Duodenal mucosa biopsies exposed to prolamins from C173 and San Pastore released higher amounts of IFN-γ, IL-2, IL-10 and anti-tTG antibodies in the culture medium than untreated controls. The line C173 differed from cv. San Pastore as it did not produce negative effects on enterocyte height, suggesting that manipulating prolamin composition can affect innate immune responses of CD mucosa to wheat gluten. Conclusions Our data demonstrated that this gliadin-deficient wheat has a lower direct toxicity but activates an immunologic reaction of the duodenal mucosa like that of the common wheat species.

Published
2011

31. Mapping genetic factors for resistance to Soil-Borne cereal mosaic virus (SBCMV) in durum wheat

Author

MARCO MACCAFERRI, CLAUDIO RATTI, CONCEPCION RUBIES AUTONELL, ROBERTO TUBEROSA, Demontis, A., Massi, A., Ambrogio, E., Stefanelli, Sandra, Vallega, V., Sanguineti, Maria Corinna, MACCAFERRI M., RATTI C., RUBIES-AUTONELL C., TUBEROSA R., DEMONTIS A., MASSI A., DE AMBROGIO E., STEFANELLI S., VALLEGA V., SANGUINETI M.C., RUBIES AUTONELL C., and DEAMBROGIO E.

Published
2008

32. QTLs associated to yield under different water and nitrogen availability in durum wheat

Author

Demontis, A., MARCO MACCAFERRI, Ammar, K., Massi, A., Deambrogio, E., Reynolds, M., Ortiz-Monasterio, I., Corneti, S., Stefanelli, S., Tuberosa, R., Sanguineti, M. C., ROSSI PISA P., DEMONTIS A., MACCAFERRI M., AMMAR K., MASSI A., DE AMBROGIO E., REYNOLDS M., ORTIZ-MONASTERIO I., CORNETI S., STEFANELLI S., TUBEROSA R., and SANGUINETI M.C.

Published
2008

33. Searching for major QTLs for tolerance to abiotic and biotic stresses in durum wheat

Author

MARCO MACCAFERRI, Sanguineti, Maria Corinna, Ambrogio, E., Demontis, A., Massi, A., Ammar, K., Araus Ortega, J. L., Ben Salem, M., Conti, Sergio, Del Moral, L. F. G., El Ahmed, A., Giuliani, Silvia, Maalouf, F., Mantovani, Paola, Nachit, M., Nserallah, N., Ortiz Monasterio, I., CLAUDIO RATTI, Reynolds, M., Royo, C., CONCEPCION RUBIES AUTONELL, Vallega, V., ROBERTO TUBEROSA, MACCAFERRI M., SANGUINETI M.C., DE AMBROGIO E., DEMONTIS A., MASSI A., AMMAR K., ARAUS ORTEGA J.L., BEN SALEM M., CONTI S., DEL MORAL L.F.G., EL-AHMED A., GIULIANI S., MAALOUF F., MANTOVANI P., NACHIT M., NSERALLAH N., ORTIZ-MONASTERIO I., RATTI C., REYNOLDS M., ROYO C., RUBIES-AUTONELL C., VALLEGA V., and TUBEROSA R.

34. Searching for wheat plants with low toxicity in celiac disease: Between direct toxicity and immunologic activation.

Author

Carroccio A, Di Prima L, Noto D, Fayer F, Ambrosiano G, Villanacci V, Lammers K, Lafiandra D, De Ambrogio E, Di Fede G, Iacono G, and Pogna N

Subjects
Antibodies metabolism, Celiac Disease immunology, Celiac Disease pathology, Gene Deletion, Humans, Interferon-gamma metabolism, Interleukin-10 metabolism, Interleukin-2 metabolism, Intestinal Mucosa immunology, Intestinal Mucosa pathology, Prolamins immunology, Tissue Culture Techniques, Triticum genetics, Triticum immunology, Celiac Disease metabolism, Intestinal Mucosa metabolism, Prolamins toxicity, Triticum toxicity
Abstract

Background: Natural or induced variations in the noxiousness of gluten proteins for celiac disease (CD) patients are currently being investigated for their potential in breeding wheat crops with reduced toxicity., Aims: We evaluated the bread wheat line C173 for its effects on the in vitro-grown duodenal mucosa of CD patients., Methods: In vitro-grown duodenal mucosa biopsies of 19 CD patients on a gluten-free diet were exposed to peptic/tryptic-digested prolamins from bread wheat line C173 lacking gliadin-glutenin subunits, analyzed for morphology, cytokine and anti-tTG antibody production, and compared with mucosa biopsies exposed to prolamins from wild-type cv. San Pastore., Results: Duodenal mucosa biopsies exposed to prolamins from C173 and San Pastore released higher amounts of IFN-γ, IL-2, IL-10 and anti-tTG antibodies in the culture medium than untreated controls. The line C173 differed from cv. San Pastore as it did not produce negative effects on enterocyte height, suggesting that manipulating prolamin composition can affect innate immune responses of CD mucosa to wheat gluten., Conclusions: Our data demonstrated that this gliadin-deficient wheat has a lower direct toxicity but activates an immunologic reaction of the duodenal mucosa like that of the common wheat species., (Copyright © 2010 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)

Published
2011
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