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2. The Association between Patient Body Mass Index and Initial Procedure Performed as Treatment of Fibroids

Author

H. Curlin, Zhizhuang Joe Zhao, D.R. Velez Edwards, L.F.B. Harvey, and K.F. Chaves

Subjects
medicine.medical_specialty, Hysterectomy, business.industry, Uterine fibroids, Obstetrics, medicine.medical_treatment, Obstetrics and Gynecology, Retrospective cohort study, Overweight, Logistic regression, medicine.disease, Obesity, female genital diseases and pregnancy complications, Obstructive sleep apnea, Medicine, medicine.symptom, business, Body mass index
Abstract

Study Objective To compare the distribution of initial procedures performed as treatment of uterine fibroids between the different classes of patient body mass index (BMI). Design Retrospective cohort study. Setting Academic medical center. Patients or Participants We included patients (N=1982) with known fibroids (based on ICD codes and ultrasound findings) who underwent a fibroid procedural intervention between 2008 and 2015. Interventions Uterine fibroid embolization (UFE), myomectomy (excluding hysteroscopic procedures), or hysterectomy Measurements and Main Results The main exposure was patient BMI class: normal weight (n=498), overweight (n=518), and class I (n=413), II (n=260), and III (n=293) obesity. The main outcome was the first fibroid procedural intervention (UFE, myomectomy, or hysterectomy) performed during the study time period. Amongst women of normal weight who underwent a fibroid procedural intervention, 67.5% of the time this procedure was hysterectomy. Comparatively, overweight women and women with class I, II, and III obesity underwent hysterectomy as their initial procedure 71.4%, 77.7%, 78.1%, and 78.8% of the time (p Multivariable logistic regression adjusted for patient age, race, and the presence of the obesity-related comorbidities of hypertension, diabetes, and obstructive sleep apnea. When compared to women of normal weight, women with class I (aOR 1.8, 95% CI 1.3-2.5, p Conclusion Obese women were significantly more likely to undergo hysterectomy as their initial fibroid procedural intervention as opposed to uterine-preserving procedures, even when adjusted for key factors that may influence a patient's and surgeon's decision regarding operative management. Future studies elaborating on indication for surgery and fibroid burden may shed light on this phenomenon.

Published
2021
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3. Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

Author

Dennis O. Mook-Kanamori, J M Gaziano, Harst Pvd., Derek Klarin, K A Birdwell, Josh C. Denny, Martin Farrall, Thibaud Boutin, Najim Lahrouchi, Nabi Shah, Scott M. Damrauer, Cecilia P. Chung, Neil Poulter, Herzig K-H., E E Siew, John Concato, Yan V. Sun, Sara M. Willems, Louise V. Wain, Philip S. Tsao, Massimo Mangino, Wei W-Q., Ioanna Ntalla, Brian S. Mautz, David Schlessinger, Daniel I. Chasman, Branwen J. Hennig, Christopher Newton-Cheh, Michael E. Matheny, Palmer Cna., Caroline Hayward, Zhao J-H., Eleftheria Zeggini, Paul Elliott, C M Lindgren, Praveen Surendran, Csaba P. Kovesdy, Jacob M. Keaton, Chengxiang Qiu, Claudia Langenberg, Christopher Oldmeadow, Stéphanie Debette, D.R. Velez Edwards, Evangelos Evangelou, Howson Jmm., Adriana M. Hung, Yaomin Xu, Nicholas J. Wareham, James P. Cook, Scott L. DuVall, Peter Almgren, Jacklyn N. Hellwege, Sébastien Thériault, Helen R. Warren, Jian'an Luan, Ching-Ti Liu, Christopher J. O'Donnell, Michael Boehnke, Peter S. Sever, Ruifang Li-Gao, Cassianne Robinson-Cohen, Robert A. Scott, Muralidharan Sargurupremraj, Mark J. Caulfield, Jarvelin M-R., Tim D. Spector, Todd L. Edwards, Elena V. Feofanova, Francesco Cucca, Jihwan Park, Savita Karthikeyan, J C Smith, Wilson Pwf., Markku Laakso, Ayush Giri, Christianne L. Roumie, Rojesh Shrestha, Claudia P. Cabrera, Kelly Cho, Laura J. Scott, Elvis A. Akwo, Yu Wang, Tom G. Richardson, Patricia B. Munroe, Eric S. Torstenson, Katalin Susztak, John Attia, Bruce M. Psaty, Aldi T. Kraja, Olle Melander, Nicholas J. Timpson, George Dedoussis, Paul M. Ridker, Niek Verweij, David Conen, Philippe Amouyel, Otis D. Wilson, Nuno Sepúlveda, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cardiology, ACS - Heart failure & arrhythmias, Cardiovascular Centre (CVC), Luan, Jian'an [0000-0003-3137-6337], Zhao, Jing Hua [0000-0003-4930-3582], Surendran, Praveen [0000-0002-4911-6077], Karthikeyan, Savita [0000-0002-4798-5746], Langenberg, Claudia [0000-0002-5017-7344], Wareham, Nicholas [0000-0003-1422-2993], Howson, Joanna [0000-0001-7618-0050], and Apollo - University of Cambridge Repository

Subjects
Male, LOCI, Gene Expression, Physiology, Blood Pressure, Genome-wide association study, IDENTIFIES 8, Mice, 0302 clinical medicine, Ethnicity, PARTITIONING HERITABILITY, Genetics & Heredity, 0303 health sciences, Kidney, Blood Pressure-International Consortium of Exome Chip Studies, Million Veteran Program, PULSE PRESSURE, 11 Medical And Health Sciences, Middle Aged, Up-Regulation, 3. Good health, Pulse pressure, Kidney Tubules, medicine.anatomical_structure, VINTAGE, International Consortium for Blood Pressure, AUTOSOMAL-DOMINANT HYPERTENSION, Female, Life Sciences & Biomedicine, Understanding Society Scientific Group, Adolescent, Diastole, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, Genetics, medicine, Animals, Humans, GENOME-WIDE ASSOCIATION, Gene, 030304 developmental biology, Genetic association, Science & Technology, 06 Biological Sciences, GLOBAL BURDEN, MEAN ARTERIAL, GENE, Blood pressure, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, SOLUBLE GUANYLYL CYCLASE, Transcriptome, 030217 neurology & neurosurgery, Genome-Wide Association Study, Developmental Biology
Abstract

International audience; In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.

Published
2019
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4. First-trimester bleeding characteristics associate with increased risk of preterm birth: data from a prospective pregnancy cohort

Author

D.R. Velez Edwards, Reem Hasan, Katherine E Hartmann, David A. Savitz, and Donna D. Baird

Subjects
Adult, Risk, Pediatrics, medicine.medical_specialty, Adolescent, Hemorrhage, macromolecular substances, environment and public health, Ultrasonography, Prenatal, Cohort Studies, Pregnancy, Odds Ratio, medicine, Humans, Vaginal bleeding, Prospective Studies, Prospective cohort study, integumentary system, business.industry, Rehabilitation, Obstetrics and Gynecology, Original Articles, Odds ratio, medicine.disease, Pregnancy Trimester, First, Reproductive Medicine, Premature birth, Cohort, Premature Birth, Regression Analysis, Female, medicine.symptom, business, Risk assessment, Cohort study
Abstract

Prior evidence linking first-trimester bleeding with preterm birth (PTB,37 weeks gestation) risk has been inconsistent and may be biased by subject selection and/or incomplete documentation of bleeding episodes for all participants. Prior studies have not carefully examined the role of bleeding characteristics in PTB risk. In the present study, we estimate the association between first-trimester bleeding and PTB in a non-clinical prospective cohort and test whether bleeding characteristics better predict risk.Women were enrolled in Right from the Start (2000-2009), a prospective pregnancy cohort. Data about bleeding and bleeding characteristics were examined with logistic regression to assess association with PTB.Among 3978 pregnancies 344 were PTB and 3634 term. Bleeding was reported by 986 (26%) participants. After screening candidate confounders, only multiple gestations remained in the model. Bleeding associated with PTB [odds ratio (OR)(adjusted) = 1.40, 95% confidence interval (CI) 1.09-1.80]. Risk did not vary by race/ethnicity. Compared with non-bleeders, PTB risk was higher for bleeding with red color (OR(adjusted) = 1.92, 95% CI, 1.32-2.82), for heavy episodes (OR(adjusted) = 2.40, 95% CI 1.18-4.88) and long duration (OR(adjusted) = 1.67, 95% CI 1.17-2.38).Bleeding associated with PTB was not confounded by common risk factors for bleeding or PTB. PTB risk was greatest for women with heavy bleeding episodes with long duration and red color and would suggest that combining women with different bleeding characteristics may affect the accuracy of risk assessment. These data suggest a candidate etiologic pathway for PTB and warrant further investigation of the biologic mechanisms.

Published
2011
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5. Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Author

Aravinda Chakravarti, Jennifer E. Huffman, Meixia Ren, Veikko Salomaa, Christopher Newton-Cheh, Johan Sundström, Alan L. James, Joris Deelen, Raha Pazoki, Michela Traglia, Tõnu Esko, Seppo Koskinen, Christopher J. O'Donnell, Csaba P. Kovesdy, Daniel I. Chasman, Paul F. O'Reilly, Roby Joehanes, Paul M. Ridker, G. Abecasis, Lars Lind, Dragana Vuckovic, Yingchang Lu, Antonietta Robino, Anders Hamsten, Muralidharan Sargurupremraj, Caterina Barbieri, Anne U. Jackson, Anna Morgan, Claudia Langenberg, Peter S. Braund, Rainer Rettig, Murielle Bochud, Vilmundur Gudnason, Eleftheria Zeggini, David J. Stott, Joop Jukema, Nick Shrine, Jun Ding, Olle Melander, Massimo Mangino, Borbala Mifsud, Frank H. Collins, Liewald Dcm., Tineka Blake, Peter K. Joshi, Yan V. Sun, Aarno Palotie, Maciej Tomaszewski, Jarvelin M-R., Kati Kristiansson, L. J. Launer, Sara M. Willems, Ian J. Deary, Christophe Tzourio, Alan J. Gow, Caroline Hayward, Guillaume Paré, Christopher Oldmeadow, John M. Starr, Paul Elliott, Morris A. Swertz, C M van Duijn, Sekar Kathiresan, Lorna M. Lopez, Neil R Poulter, Mike A. Nalls, Erik Ingelsson, Eric Boerwinkle, Catharina A. Hartman, Giorgia Girotto, Ben A. Oostra, Markus Perola, Paul Knekt, Lyytikäinen L-P., T.B. Harris, J. C. Bis, Harriëtte Riese, J. Marrugat, Samuli Ripatti, Howson Jmm., Archie Campbell, C M Lindgren, Adam S. Butterworth, Xiuqing Guo, Lin W-Y., Priyanka Nandakumar, David Mosen-Ansorena, Alison Pattie, Marco Brumat, Annette Peters, Georgios Ntritsos, Ivana Kolcic, Alexander Teumer, Ulf Gyllensten, Joanne Knight, Stella Trompet, K. Witkowska, Hottenga J-J., Tim D. Spector, Maris Laan, Vilmantas Giedraitis, Bram P. Prins, Loos Rjf., M. H. de Borst, Antti Jula, Lynda M. Rose, Massimiliano Cocca, Daniela Toniolo, Igor Rudan, P. J. van der Most, Fu Liang Ng, Heather J. Cordell, Walter Palmas, John Danesh, John Attia, Dan E. Arking, Ganesh Chauhan, C Gieger, P. van der Harst, Penninx Bwjh., Kristin L. Ayers, Germaine C. Verwoert, Bruce M. Psaty, Jaspal S. Kooner, Ruifang Li-Gao, Benjamin Lehne, Khaw K-T., Sandosh Padmanabhan, Franco Giulianini, Erwin P. Bottinger, Roberto Elosua, Christopher P. Nelson, Ozren Polasek, D.R. Velez Edwards, Martin Farrall, Ioanna Tzoulaki, Peter Vollenweider, Uwe Völker, Albertine J. Oldehinkel, Åsa Johansson, Helen R. Warren, Evan Tzanis, Albert V. Smith, Hwang S-J., Teresa Ferreira, E.J.C. de Geus, Evangelos Evangelou, Niek Verweij, R. J. Scott, Pekka Jousilahti, Elin Org, Stefan Enroth, Dorret I. Boomsma, Harry Campbell, Andrew D. Johnson, David Conen, James F. Wilson, Edward G. Lakatta, Anuj Goel, Raymond Noordam, Najaf Amin, David P. Strachan, Martin D. Tobin, Francesco Cucca, Doney Asf., Todd L. Edwards, Jerome I. Rotter, Mika Kähönen, Hugh Watkins, Rossella Sorice, John M. C. Connell, David S. Siscovick, Sébastien Thériault, Jian'an Luan, Marty Larson, Philippe Amouyel, A C Morrison, Louise V. Wain, Reedik Mägi, Jonathan Marten, Thibaud Boutin, Nabi Shah, Weihua Zhang, Palmer Cna., Daniela Ruggiero, Zhao J-H., Olli T. Raitakari, Bernard Keavney, Peter S. Sever, Philip S. Tsao, Jie Yao, André G. Uitterlinden, Marina Evangelou, Zoltán Kutalik, Robert A. Scott, Helena Schmidt, J. Tuomilehto, Nilesh J. Samani, Quang Tri Nguyen, John Michael Gaziano, Georg Ehret, Praveen Surendran, Terho Lehtimäki, Mark J. Caulfield, Denis C. Shields, Rick Jansen, Sarin A-P., Alice Stanton, Mattias Frånberg, Cumhur Y Demirkale, Stéphanie Debette, Paolo Gasparini, Ilaria Gandin, Simon Thom, Kent D. Taylor, Andrew D. Morris, Claudia P. Cabrera, Teemu J. Niiranen, Nicholas J. Wareham, Andrew P. Morris, Yasaman Saba, Daniel Levy, Aki S. Havulinna, Kelly Cho, Sarah E. Harris, Li Lin, Janina S. Ried, Michael R. Barnes, Sarah H. Wild, Patricia B. Munroe, Vergnaud A-C., Lorenz Risch, Rona J. Strawbridge, Y. Milaneschi, John C. Chambers, Yong Qian, Cristina Menni, Anubha Mahajan, Peter Almgren, Gary Davies, Jacklyn N. Hellwege, Elizabeth G. Holliday, A. Metspalu, Ilja M. Nolte, Peter J. Munson, He Gao, Marcus Dörr, Cinzia Sala, Peter P. Pramstaller, Teresa Nutile, Wilson Pwf., Gonneke Willemsen, Markku Laakso, Chiara Batini, Harold Snieder, Ibrahim Karaman, Adriana M. Hung, Reinhold Schmidt, R. de Mutsert, Michael Boehnke, Lili Milani, Alan F. Wright, Edith Hofer, Siim Sõber, Ahmad Vaez, Albert Hofman, Oscar H. Franco, Yongmei Liu, Tatijana Zemunik, Kenneth Rice, Veronique Vitart, Marina Ciullo, Niki Dimou, Morris J. Brown, Crysovalanto Mamasoula, A.M. Erzurumluoglu, Andrew A. Hicks, Ayush Giri, Dennis O. Mook-Kanamori, Home Office, UNIVERSITY OF OULU, Commission of the European Communities, Medical Research Council (MRC), Action on Hearing Loss, British Heart Foundation, National Institute for Health Research, Imperial College Healthcare NHS Trust- BRC Funding, and UK DRI Ltd

Subjects
Genetics & Heredity, 0301 basic medicine, Netherlands Twin Register (NTR), Science & Technology, computer.internet_protocol, Million Veteran Program, Genome-wide association study, Computational biology, 06 Biological Sciences, Biology, Genetic analysis, 03 medical and health sciences, 030104 developmental biology, Genetics, Genome informatics, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Life Sciences & Biomedicine, computer, 11 Medical and Health Sciences, XML, Developmental Biology
Abstract

In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly in the XML. The error has now been corrected in the HTML version of the paper.

Published
2018
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6. Parkinson Disease Loci in the mid-Western Amish

Author

William K. Scott, Jonathan L. Haines, Denise Fuzzell, Renee Laux, Margaret A. Pericak-Vance, Lan Jiang, D.R. Velez Edwards, Stephen L. Lee, Anna C. Cummings, Mary F. Davis, Laura D'Aoust, and Lori Reinhart-Mercer

Subjects
Indiana, Genotype, Genetic Linkage, Population, Genome-wide association study, Biology, Polymorphism, Single Nucleotide, Article, Locus heterogeneity, Genetic linkage, Genetics, medicine, Humans, Genetic Predisposition to Disease, education, Genetics (clinical), Ohio, Linkage (software), education.field_of_study, Genetic heterogeneity, Chromosomes, Human, Pair 10, Genome, Human, Computational Biology, Parkinson Disease, medicine.disease, Human genetics, Pedigree, Genetic Loci, Chromosomes, Human, Pair 5, Chromosomes, Human, Pair 6, Amish, Genome-Wide Association Study
Abstract

Previous evidence has shown that Parkinson disease (PD) has a heritable component, but only a small proportion of the total genetic contribution to PD has been identified. Genetic heterogeneity complicates the verification of proposed PD genes and the identification of new PD susceptibility genes. Our approach to overcome the problem of heterogeneity is to study a population isolate, the mid-western Amish communities of Indiana and Ohio. We performed genome-wide association and linkage analyses on 798 individuals (31 with PD), who are part of a 4,998 member pedigree. Through these analyses, we identified a region on chromosome 5q31.3 that shows evidence of association (p value

Published
2013

7. 13: Genetic determinants of pelvic organ prolapse in women of european american descent: The women’s health initiative

Author

Kari E. North, Christy L. Avery, Renée M Ward, Misa Graff, Barbara V. Howard, Todd L. Edwards, Nawar Shara, Ayush Giri, Jennifer M. Wu, D.R. Velez Edwards, and Amy J. Park

Subjects
Pelvic organ, medicine.medical_specialty, business.industry, Women's Health Initiative, Processing cost, Obstetrics and Gynecology, Cost savings, Surgery, Patient safety, Unexpected events, Medicine, Operations management, business, health care economics and organizations
Abstract

CONCLUSION: Instrument utilization in the Gynecologic operating room is low but comparable to other surgical specialties, and the cost of processing instruments is significant. Availability of certain instruments is necessary for patient safety in the event of rare unexpected events. However, given that significantly less than half of the instruments pulled for surgery are utilized and that total processing cost per instrument exceeds three dollars, careful review of what instruments are included in each tray and elimination of wasted resource allocation can result in significant cost savings without reducing safety.

Published
2016
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8. Synopsis of preterm birth genetic association studies: the preterm birth genetics knowledge base (PTBGene)

Author

Siobhan M. Dolan, Muin J. Khoury, Sachin Bagade, X. Zheng, R. A. Dubin, Lars Bertram, Bruce K. Lin, Judith Nace, Ramkumar Menon, Mario Merialdi, Tomas Allen, Chaya B. Abelow, M. V. Hollegaard, Ana Pilar Betrán, John P. A. Ioannidis, and D.R. Velez Edwards

Subjects
medicine.medical_specialty, Genes/*genetics, Knowledge Bases, Bioinformatics, Field (computer science), Meta-Analysis as Topic, Pregnancy, Medicine, Humans, Genetic Predisposition to Disease, Genetics (clinical), Genetic association, Premature Birth/*genetics, Polymorphism, Genetic, business.industry, Public Health, Environmental and Occupational Health, Online database, Infant, Newborn, Knowledge base, Genes, Meta-analysis, Family medicine, Polymorphism, Genetic/*genetics, Premature Birth, Female, business, Genome-Wide Association Study
Abstract

Aim: Our goal wasto produce a field synopsis of genetic associations with preterm birth and to set up a publicly available online database summarizing the data. Methods: We performed a systematic review and meta-analyses to identify genetic associations with preterm birth. We have set up a publicly available online database of genetic association data on preterm birth called PTBGene (http://ric.einstein.yu.edu/ptbgene/index.html) and report on a structured synopsis thereof as of December 1, 2008. Results: Data on 189 polymorphisms in 84 genes have been included and 36 meta-analyses have been performed. Five gene variants (4 in maternal DNA, one in newborn DNA) have shown nominally significant associations, but all have weak epidemiological credibility. Conclusion: After publishing this field synopsis, the PTBGene database will be regularly updated to keep track of the evolving evidence base of genetic factors in preterm birth with the goal of promoting knowledge sharing and multicenter collaboration among preterm birth research groups.

Published
2010

10. Exome chip evaluation of genetic variants for association with uterine fibroids

Author

Todd L. Edwards, D.R. Velez Edwards, and Katherine E Hartmann

Subjects
Gynecology, medicine.medical_specialty, Uterine fibroids, business.industry, Genetic variants, Obstetrics and Gynecology, Institute of medicine, medicine.disease, Bioinformatics, Reproductive Medicine, Obstetrics and gynaecology, Epidemiology, medicine, business, Exome
Abstract

EXOMECHIP EVALUATION OF GENETIC VARIANTS FOR ASSOCIATION WITH UTERINE FIBROIDS. T. L. Edwards, K. E. Hartmann, D. R. Velez Edwards. Department of Medicine and Division of Epidemiology, Nashville, TN; Vanderbilt Epidemiology Center, Nashville, TN; Center for Human Genetics Research, Nashville, TN; Institute of Medicine and Public Health, Nashville, TN; Department of Obstetrics and Gynecology, Nashville, TN.

Published
2014
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11. Common genetic variants may identify women with large uterine fibroids on ultrasound: the cardia women’s study (CWS)

Author

Katherine E Hartmann, D.R. Velez Edwards, Melissa Wellons, Todd L. Edwards, and M. Fornage

Subjects
Gynecology, medicine.medical_specialty, Reproductive Medicine, Obstetrics and gynaecology, Uterine fibroids, business.industry, medicine, Genetic variants, Obstetrics and Gynecology, medicine.disease, business, Body mass index, Preventive healthcare
Abstract

ASSOCIATION OF BODY MASS INDEX (BMI) AND ADIPOKINES WITH THE PREVALENCE OF FIBROIDS IN YOUNG AFRICANAMERICAN WOMEN: A CASE-CONTROL STUDY. E. E. Marsh, M. Steinberg, L. Bernardi, P. de Chavez, M. S. Ghant, L. M. Neff, M. Carnethon. Obstetrics and Gynecology REI Division, Northwestern University Feinberg School of Medicine, Chicago, IL; Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL; Medicine Division of Endocrinology andMetabolism, Northwestern University Feinberg School of Medicine, Chicago, IL.

Published
2014
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