1. Rapid methods for determination of fluoxetine in pharmaceutical formulations
- Author
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D Visini, Vincenzo Pucci, G. Varani, Meri Raggi, and Roberto Mandrioli
- Subjects
Chromatography ,Chemistry ,Capillary action ,Clinical Biochemistry ,Extraction (chemistry) ,Fluorescence spectrometry ,Electrophoresis, Capillary ,Reproducibility of Results ,Pharmaceutical Science ,Capsules ,Electrolyte ,Dosage form ,Analytical Chemistry ,Dilution ,Spectrometry, Fluorescence ,Capillary electrophoresis ,Fluoxetine ,Drug Discovery ,Quantitative analysis (chemistry) ,Spectroscopy - Abstract
Two different analytical methods for the quality control of fluoxetine in commercial formulations have been developed and compared: a spectrofluorimetric method and a capillary zone electrophoretic (CZE) method. The fluorescence emission values were measured at λ =293 nm when exciting at λ =230 nm. The CZE method used an uncoated fused-silica capillary and pH 2.5 phosphate buffer as the background electrolyte. The extraction of fluoxetine from the capsules consisted of a simple one-step dissolution with methanol/water, filtration and dilution. Both methods gave satisfactory results in terms of precision; the best results were obtained for the electrophoretic method, with RSD% values always lower than 2.0%. The accuracy was assessed by means of recovery studies, which gave very good results, between 97.5 and 102.6%. Furthermore, both methods also have the advantage of being very rapid.
- Published
- 2002