1. 68Ga-PSMA PET/CT vs. mpMRI for locoregional prostate cancer staging: correlation with final histopathology
- Author
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Raymond Ko, Celi Varol, D. V. Shetty, Richard Ferguson, I. Berger, C. Annabattula, Mohamed Khadra, Mohan Arianayagam, J. Lewis, Han Loh, B. Canagasingham, F. Maclean, Jonathan Kam, and Matthew Winter
- Subjects
Cancer Research ,PET-CT ,medicine.medical_specialty ,medicine.diagnostic_test ,Index Lesion ,business.industry ,Prostatectomy ,Urology ,medicine.medical_treatment ,urologic and male genital diseases ,medicine.disease ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Oncology ,Positron emission tomography ,030220 oncology & carcinogenesis ,medicine ,Histopathology ,Prostate cancer staging ,Nuclear medicine ,business ,Multiparametric Magnetic Resonance Imaging - Abstract
Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) can be used to locate lesions based on PSMA avidity, however guidelines on its use are limited by its infancy. We aimed to compare multiparametric magnetic resonance imaging (mpMRI) and PSMA PET/CT to prostatectomy histopathology. We conducted a chart review from February 2015 to January 2017 of 50 male patients staged for prostate cancer using PSMA PET/CT and mpMRI who then underwent radical prostatectomy. Pre-operative PSMA PET/CT and mpMRI were paired with corresponding histopathology. Correlations, sensitivity, and specificity were used for comparisons. A total of 81 lesions were confirmed by histopathology. Fifty index lesions were detected by histopathology, all of which were detected by PSMA PET/CT (100% detection), and 47 by mpMRI (94% detection). Thirty-one histologically confirmed secondary lesions were detected, 29 of which were detected by PSMA PET/CT (93.5% detection), and 16 by mpMRI (51.6% detection). PSMA had better sensitivity for index lesion localization than mpMRI (81.1 vs. 64.8%). Specificity was similar for PSMA PET/CT and mpMRI (84.6 vs. 82.7%). SUVmax of index lesions ranged from 2.9 to 39.6 (M = 9.27 ± 6.41). Index lesion SUVmax was positively correlated with PSA (rho = 0.48, p
- Published
- 2018