1. Bone Tissue Engineering: 3D PCL-based Nanocomposite Scaffolds with Tailored Properties
- Author
-
Francesco Langella, D. Ronca, Teresa Russo, Paulo Jorge Da Silva Bartolo, Ugo D'Amora, Antonio Gloria, Marco Domingos, Luigi Ambrosio, and Marianna Chierchia
- Subjects
Materials science ,Additive Manufacturing ,0206 medical engineering ,Nanoparticle ,02 engineering and technology ,Tissue Regeneration ,Bone tissue ,Bone tissue engineering ,Nanocomposite scaffolds ,Biological property ,medicine ,Bone ,General Environmental Science ,Nanocomposite Scaffolds ,Nanocomposite ,Manufacturing process ,Regeneration (biology) ,021001 nanoscience & nanotechnology ,Autologous bone ,020601 biomedical engineering ,medicine.anatomical_structure ,Tissue regeneration ,General Earth and Planetary Sciences ,0210 nano-technology ,Biomedical engineering - Abstract
In the field of reconstructive surgery, a great challenge is represented by bone injuries beyond the self-repair threshold. Autologous bone grafts may be considered the gold standard. Anyway, such approach is limited by the amount of tissue required for grafting and by donor site morbidity. To overcome these drawbacks, bone tissue engineering represents a promising solution. 3D fully biodegradable and nanocomposite scaffolds for bone tissue regeneration, consisting of poly(ɛ-caprolactone) (PCL) reinforced with hydroxyapatite (HA) nanoparticles, were developed using an additive manufacturing process. The effect of nanoparticles and architecture (i.e., lay-down pattern) on the mechanical/functional and biological properties was discussed.
- Published
- 2016
- Full Text
- View/download PDF