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The present investigation was conducted to assess the effect of different seed soaking treatments and media on growth and alkaloid content of Indian cheese maker–Withania coagulans (Stocks) Dunal. to develop effective nursery production technology. The experiment was conducted in completely randomized design with factorial concept, including twenty treatment combinations comprising of four levels of seed treatments with GA3 (0, 50, 100, 150 ppm) and five levels of different growing media. Among various concentrations of GA3 as pre-soaking treatment, 100 ppm GA3 (S3) showed significantly better results for germination, growth, biomass and alkaloid content in W. coagulans. Similarly, among growing media, red soil (M1) recorded maximum germination percentage, collar diameter, number of branches per plant, number of leaves per plant, total leaf area, length of the main root, thickness of main root, root dry biomass, shoot dry biomass, fresh weight of plant, dry weight of plant, survival percentage of the plant and total alkaloid content of plant. Overall, the result indicated that that pre-sowing W. coagulans seeds with GA3 -150 ppm for 24 hrs and subsequently sowing treated seeds in M1 media comprising of red soil (control) can enhance growth and alkaloid content.

The different elements are essentials for growth and fertilization of plants. Such as carbon, nitrogen, phosphorous, potash and some other materials are essential for plants in proper proportion. The qualities of soil are different at different area and it also fit for different crops. We analyzed thousands of soil samples by using various chemical and instrumental methods for Daskroi-taluka of Ahmedabad District, like pH metry, conductometry, colorimetric. Here action of soil measured by pH, amount of soluble salt measured by Electric conductivity, organic carbon and phosphorous measured by colorimetric and potash measured by flame photometer. These results also compare with the standard elemental data available for particular crops. Finally we explore excess or deficiency of carbon, nitrogen, phosphorous, potash and some other materials in the soil and discussed some important results for the land of Daskroi-taluka of Ahmedabad district.

Aim: To study the safety profile and effectiveness of Anti Snake venom (ASV) in western India Methods: This retrospective study gathered safety, and clinicoepidemiologicaldata on 157 patients admitted at Shri Sainath Hospital, Dharampur, Gujarat, from July 2022 to February 2023. Results: Majority were bitten between August and November. There were 88 males, 5 to70 yrs. (mean 39.14), 69 females, 2 to 70 years (mean 40.32). 6 of these were children ranging from 2 to 12 years.134 were agricultural labourers. 120 cases were analysable. 17 had neurotoxicity and 103 had haemotoxicity. Mean (SD) number of vials used was 10.1(6.2), time to discontinue ASV was 3.0(5.2) hours, and duration of hospital stay was 4.5(2.6) days. Patients bitten by saw scaled vipers were discharged early. In Russel’s Viper bites, number of vials used, was higher if the bite to needle time was less than 6 hours 9 patients suffered 24 adverse events, with two possible cases of anaphylaxis. One case had urticaria, itching and tachycardia as a triad. The remaining were isolated events of mild urticaria, itching, tachycardia, hypotension, cough, rigor. Conclusion: 10.1 vials were needed on average for control of envenomation with no fatalities or severe comorbidities. Adverse events were reported in 5.7% cases. The ASV brand used was well tolerated. Patients who were brought late suffered more renal complications [ABSTRACT FROM AUTHOR]

Abstract People with type 1 and type 2 diabetes are at risk of developing progressive chronic kidney disease (CKD) and end-stage kidney failure. Hypertension is a major, reversible risk factor in people with diabetes for development of albuminuria, impaired kidney function, end-stage kidney disease and cardiovascular disease. Blood pressure control has been shown to be beneficial in people with diabetes in slowing progression of kidney disease and reducing cardiovascular events. However, randomised controlled trial evidence differs in type 1 and type 2 diabetes and different stages of CKD in terms of target blood pressure. Activation of the renin-angiotensin-aldosterone system (RAAS) is an important mechanism for the development and progression of CKD and cardiovascular disease. Randomised trials demonstrate that RAAS blockade is effective in preventing/ slowing progression of CKD and reducing cardiovascular events in people with type 1 and type 2 diabetes, albeit differently according to the stage of CKD. Emerging therapy with sodium glucose cotransporter-2 (SGLT-2) inhibitors, non-steroidal selective mineralocorticoid antagonists and endothelin-A receptor antagonists have been shown in randomised trials to lower blood pressure and further reduce the risk of progression of CKD and cardiovascular disease in people with type 2 diabetes. This guideline reviews the current evidence and makes recommendations about blood pressure control and the use of RAAS-blocking agents in different stages of CKD in people with both type 1 and type 2 diabetes.

Surface texturing plays an increasingly important role as it can directly influence the tribological behaviors of contact surfaces in many ways. In texturing, tribological performance depends upon the types of design texture used and methods of fabricating texture on the surface. In this research work, friction and wear behaviors of surface textured EN-31 alloy steel have been investigated under wet condition by using DUCOM linear reciprocating tribometer. The textured dimples are fabricated by micro-EDM and micro-drilling CNC machining processes. Initially un-textured surfaces of EN-31 alloy steel with EN-8 steel pin are experimented for friction and wear under ISO-68 and ISO-220 lubricant oil. Under the different normal load conditions, it has been observed that the ISO 68 oil gives better friction-wear characteristics with respect to ISO-220 oil. Then after textured surfaces were investigated by using optimized ISO-68 lubricant. Experimental results on micro-EDM provide better friction and wear properties with respect to micro-drilling CNC. Surface texturing may act as wear debris trapper, lubricant reservoirs, hydrodynamic lift, and retarding the lubricant molecules flow in a particular path where potential exists. In this work, it has observed that texturing by micro-EDM enhanced mixed lubrication and minimum friction in mixed lubrication leads to decrement of wear loss

A gas jet produced by adiabatic expansion of gas through a slit nozzle into a vacuum has been served as a target in the study of high harmonic generation or laser wakefield electron acceleration. In this work, Mach–Zehnder interferometry was utilized to obtain the gas density distribution in an argon cluster gas jet produced from a supersonic slit nozzle. The interference fringe distortion caused by the gas jet along the slit width under high backing pressure was recorded and inverted to a gas density profile. The gas backing pressure was up to 80 bars to obtain a gas jet with a higher density. It is found that the gas density in the jet is not uniform along the width direction of the slit nozzle and is the highest at the center of the jet. Along the gas jet, the highest gas density roughly decreases linearly. However, a steep density gradient is observed at P0 = 60–80 bars. Meanwhile, the highest gas density depends linearly on the gas backing pressure and the degree of dependence gradually decreases along the gas jet.

Abstract Farming in India is experiencing a structural change leading to a crisis. The growth rate of agricultural output is steadily declining in recent years. The relative contribution of the farming sector to the total GDP has been decreasing over time increasingly. The present study was conducted in Ahmedabad district of Gujarat, India. Total 100 agricultural landholders from 20 villages were selected to identify factors experienced by them for avoiding farming as a livelihood by employing Ex-Post-Facto research design. It is observed that ‘r’ computed between factors to avoid agriculture as a livelihood and age (0.589), education (0.330), farming experience (0.250), occupation (0.446), livestock possession (0.207), annual income (− 0.236) was found to be significant at 0.01 level of significance. It could be observed from regression analysis that the personal factors had a powerful effect (0.730) on avoiding agriculture as a profession, influencing in a positive direction. Followed by this, economic factor (0.291) and social factor (0.229) also influenced positively and significantly. The information on the personal, social, economic, psychological, market, situational, labor and next-generation factors experienced by agricultural landholders is analyzed to have in-depth knowledge of each factor. The analyzed suggestions will help to make agriculture a profitable enterprise and attract the farmers and youths to continue the farming activities. The solution to the problem is not in a few packages and programs but in drastic changes in the present policies related to agriculture need to be focused. Other sector’s growth and development must not be at the cost of agriculture.

Surface texturing plays a significant role on the tribological performance of contact surfaces. The tribological characteristics are mostly dependent upon the different pattern and methods of surface texturing. This research works investigates lubricated wear behaviour on circular dimples textured EN-31 alloy steel materials using DUCOM linear reciprocating tribometer. The surface dimples are fabricated by micro-EDM and micro-drilling CNC methods. Initially plane surfaces are tested under different lubricants ISO-68 and ISO-220 oil on a couple of EN31 plates with EN8 steel pin. At loading conditions the results clearly shows that the ISO 68 oil gives better performance than ISO-220 oil in terms of frictional force and COF. The operation during test under ISO-220 oil observed is very noisy and wear rate is also more. Then after experiments under different load conditions on textured surfaces were investigated using optimized ISO-68 oil. An experimental results on m-EDM provides superior frictional characteristics with respect to m-CNC. Surface texturing may act as wear debris trapper, lubricant reservoirs, hydrodynamic lift, and retarding the lubricant molecules flow in a particular path where potential exists. Here micro-dimples EDM surface textures can enhance mixed lubrication and in mixed lubrication the friction is least and this may leads to decrement of wear loss.

Magnesium alloys have generated renewed interest as a light alloys; replacing some conventional structural materials for weight reduction in applications like aerospace, automotive and electronics industries. In interior components and powertrains, cast alloys are widely used and represent more than 99% of magnesium alloys used today, whereas only a few wrought products are used. Mostly in automotive applications, Mg-engine block can noticeably reduce the weight and consequently its fuel consumption and environmental impact. Due to solid-state precipitates, these alloys are strong in nature and are produced by an age-hardening heat treatment process. In the present work the age hardening behavior of the as cast Mg–Zn–Al alloys (ZA85 alloy) in the composition of 8 wt. %Zn, 5 wt. %Al has been investigated. Through the differential thermal analysis (DTA) studies, it has been found out that dissolution temperature of ternary eutectic precipitates is present in the alloy. Based on the DTA results, the as cast samples have been solutionised at 360 °C temperature for different intervals of time. Solutionising time has been optimized from the enthalpy values of un-dissolved precipitates. The solution treated samples have been then aged at temperature of 180° C for different time intervals. From the peak hardness values, the ageing conditions have been optimized.

The use of multiple current terminals on millimeter-scale graphene p-n junction devices fabricated with Corbino geometries, or quantum Hall resistance dartboards, has enabled the measurement of several fractional multiples of the quantized Hall resistance at the ν = 2 plateau (RH ≈ 12 906 Ω). Experimentally obtained values agreed with the corresponding numerical simulations performed with the LTspice circuit simulator. More complicated designs of the quantum Hall resistance dartboard were simulated to establish the potential parameter space within which these Corbino-type devices could output resistance. Most importantly, these measurements support simpler processes of ultraviolet lithography as a more efficient means of scaling up graphene-based device sizes while maintaining sufficiently narrow junctions.

Aim: This study aimed to evaluate the efficacy of Doublesynch and Estradoublesynch protocols on estrus induction, conception rates, plasma progesterone, protein, and cholesterol profile in anestrus Gir heifers. Materials and Methods: In this study, 50 pubertal anestrus Gir heifers were selected from the field and farm conditions. The heifers were dewormed (injection ivermectin, 100 mg, s/c) and supplemented with minerals and vitamins (injection organic phosphorus 800 mg and injection Vitamin AD3E and Biotin 10 ml i/m) and multi-mineral bolus at 1 bolus daily for 7 days. The heifers were randomly divided into three groups: Doublesynch (n=20), Estradoublesynch (n=20), and control (n=10). The animals were monitored for estrus response, estrus interval, behavioral signs, and conception rates after induced/first, second, and third cycle post-treatment. Blood samples were obtained on day 0, day 9, day 12, and on day 12 post-artificial insemination (AI) for determination of plasma progesterone, protein, and cholesterol profile. Results: The estrus response rate between Doublesynch and Estradoublesynch protocols was similar between treated heifers (85% and 95%). The interval from the second prostaglandin F2α (PGF2α) injection to estrus induction did not differ between the groups (63.87±4.19 vs. 58.27±3.83 h). The conception rates following induced estrus (20% vs. 30%), at the second cycle (23.07% vs. 16.66%), at the third cycle (22.22% vs. 30.00%), and the overall conception rate (45% and 55%) within 27.89±5.75 and 26.45±5.48 days were the same across the treatment groups. The mean plasma progesterone concentrations were significantly (p

Context: Elder abuse has devastating consequences such as poor quality of life, psychological distress and loss of property and security. Abuse of elderly patients with depression has not been adequately researched in India. Aims: To explore the prevalence and predictors of abuse and its relation to various sociodemographic variables in elderly patients with depression. Settings and Design: A cross-sectional, observational study carried out at a tertiary care centre in Jamnagar. Methods and Materials: In all, 100 elderly patients with depression, attending Out Patient Department of Psychiatry at Shree M. P. Shah Government Medical College and Guru Gobind Singh Hospital, Jamnagar, were selected using simple random sampling by lottery method. Actual Abuse Tool and Elder Abuse Suspicion Index were used to detect abuse. Geriatric Depression Scale was used to assess depression, and Mini Mental State Examination was used to rule out dementia. Statistical Analysis: Descriptive statistics, Chi-square test, and binary logistic regression were used. Results: The prevalence of abuse was 24%. Among those who had experienced abuse, 50% had experienced psychological abuse, 17% had experienced neglect, 8% had experienced exploitation and 4% had experienced physical abuse. About 54% of patients with severe depression had experienced abuse. Daughters-in-law (54%) and sons (42%) were the most common perpetrators. Illiteracy and severe depression were found to be the predictors of abuse. Conclusion: Prevalence of abuse in elderly patients with depression is high. Severe depression and illiteracy are important predictors of experiencing abuse.

Aim: The work was conducted to diagnose peste des petits ruminants (PPR) outbreak through an in house developed indirect ELISA (thereafter referred as iELISA) its comparison with other available diagnostic tests and description of practical considerations in its development, utility and limitations. Materials and Methods: An outbreak resembled to PPR occurred in two different places of southern Gujarat viz. Vapi and Navsari, affecting 622 animals, including both goat (n = 476) and sheep (n = 146). Animals displayed the typical signs of PPR at Vapi; however diarrhea was the inconsistent feature in animals of Navsari. The affection caused morbidity of 100% and mortality were 73.68% (n = 392/532) and 56.67% (n = 51/90) in Vapi and Navsari outbreaks, respectively. Relevant ante mortem and post mortem samples were collected from representative animals. At the outset of the epidemic no kit was available with us, so agar gel immunodiffusion (AGID) was carried out and a commercial ELISA (cELISA) kit was ordered for making diagnosis through antibody demonstration. Meanwhile, an iELISA was developed in house using PPR vaccine as antigen and protein G conjugated HRPO antibody as detector. Histopathology and results of sandwich ELISA were also used to diagnose PPR virus (PPRV) in the outbreak. Results: The iELISA developed had detected PPRV antibodies in 22/24 samples (91.66%). Significant difference was observed in disease sensitivity pattern of two species by Chi-square test. While AGID failed to detect antibodies in any sample. Results were reconfirmed by comparing with commercially available cELISA kit. Conclusion: PPR is an economically important disease and for the rapid diagnosis of PPR the in house developed antibody capture iELISA can be a suitable cost effective alternative.

This paper presents the design, analysis, and experimental validation of the passive case of a variable stiffness suspension system. The central concept is based on a recently designed variable stiffness mechanism. It consists of a horizontal control strut and a vertical strut. The main idea is to vary the load transfer ratio by moving the location of the point of attachment of the vertical strut to the car body. This movement is controlled passively using the horizontal strut. The system is analyzed using an L2-gain analysis based on the concept of energy dissipation. The analyses, simulation, and experimental results show that the variable stiffness suspension achieves better performance than the constant stiffness counterpart. The performance criteria used are; ride comfort, characterized by the car body acceleration, suspension deflection, and road holding, characterized by tire deflection.

Complexes of Co(II), Ni(II) and Cu(II) were synthesized from Schiff base 2-{[(2-aminophenyl)imino]methyl}phenol and metformin. The authenticity of the transition metal complexes were characterized by elemental analyses, conductance and magnetic susceptibility measurements, as well as spectroscopic (IR, electronic) and thermal studies. IR spectral studies revealed the existence of the ligands in the amine form in the solid state. The magnetic and electronic spectral studies suggest an octahedral geometry for all the complexes. The metformin acts as a bidentate ligand and Schiff base of o-phynelendiamine and salicylaldehyde acts as a tridentate ligand. Antimicrobial screening of the Schiff base, metformin and transition metal complexes were determined against the bacteria Escherichia coli and Bacillus megaterium.

Novel bisazo-bisazomethine disperse dyes were prepared by the coupling of diazotized solutions of various aromatic amines with 2,2'-{sulfonylbis [4,1-phenylene nitrilomethylylidene]} diphenol (SB). Above Schiff base was prepared by the condensation of 2-hydroxybenzaldehyde with 4,4’-sulphonyl- dianiline (Dapson). The resultant dyes were characterized by elemental analysis, IR and1H NMR spectral studies. The UV Visible absorption spectral data were investigated in dimethylformamide (DMF) and are discussed in terms of structural property relationship. Their dyeing performance as disperse dyes has been assessed on polyester fabrics. The results show that a better hue was obtained on polyester fabrics and have mild to moderate fastness properties.

To study the metal ligand equilibrium in aqueous solution, the well known Irving-Rossotti titration method was used. The temperature selected is 30±0.10C at ionic strength 0.2 M (NaClO4) which was maintained constant through out the work. The binary metal complex (ML2) formation was studied. The metals selected are Sm3+, Gd3+, Dy3+ and Yb3+. The diamine ligands taken are ethylenediamine, 1,2 diamino propane, 1,3 diamino propane, N-N diethyl ethylenediamine and N-N -dimethyl ethylenediamine. Factors that affected the stability of the complexes are size and ionic potential of lanthanone ions, basicity of ligands, ring size and steric effect of ligands.

We introduce a new class of mappings satisfying the “common limit range property” in symmetric spaces and utilize the same to establish common fixed point theorems for such mappings in symmetric spaces. Our results generalize and improve some recent results contained in the literature of metric fixed point theory. Some illustrative examples to highlight the realized improvements are also furnished.

A novel mutation of low density lipoprotein (LDL)-receptor gene was found in an Italian family hypercholesterolemia (FH) patient during a screening of 300 FH patients. The proband as well as her daughter were found to be heterozygotes for the mutation. Binding, internalization, and degradation of 125I-labeled LDL by the proband's fibroblasts were reduced to approximately 50% compared to values found in control cells. DNA analysis by Southern blotting showed that the mutant allele was characterized by an insertion of about 10 kb, which resulted from a duplication of exons 9-14 of the LDL-receptor gene. In addition, Northern blot analysis of the proband's RNA showed, besides the normal sized LDL-receptor mRNA (5.3 kb), an additional mRNA of about 6.2 kb. The junction between exon 14 and the duplicated exon 9 was amplified by polymerase chain reaction (PCR) from the cDNA. The sequence of the amplified fragment showed that exon 14 joined the duplicated exon 9 without changing the reading frame. The derived amino acid sequence indicated that the mutated receptor protein had a partial duplication of the EGF precursor homology domain. Ligand and immunoblotting revealed that proband's fibroblasts contained one-half of the normal amount of LDL-receptor protein (molecular mass 130 kDa) and an abnormally large receptor of approximately 160 kDa. The amount of this abnormal receptor as detected by two monoclonal antibodies (10A2 and 4B3) was found to be approximately 30% that of the normal LDL-receptor present in the same cells.(ABSTRACT TRUNCATED AT 250 WORDS)

Mucoadhesive drug delivery systems are those that provide intimate contact of the drug with the mucosa for an extended period of time. In present work, mucoadhesive chitosan microspheres of Levosalbutamol sulphate were prepared by Spray drying method. Formulations were characterized for various physicochemical attributes size, encapsulation efficiency, swelling ability, in vitro release study and mucoadhesion study by rat ileum. Through these parameters we conclude that the batch B 2 was found to be best mainly by mucoadhesion study and in vitro drug release. Mucoadhesion was found to be increased with incresed concentration of polymer and visa versa in case of drug release. Batch B 3 had also similar results with that of Batch B 2 . That′s why here Batch B 2 was said to be the best batch with less polymeric content as compare to Batch B 3 .

[Vet World 2009; 2(7.000): 283-283]