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To cope with massive development, many urban and surrounding rural areas have been agglomerated into a greater metropolitan area, aiming for regional economic development. Many of these metropolitan areas have experienced a dramatic increase in impacted area and economic loss from annual flooding. The issues and challenges emerging from transboundary river flood risk management have become a major concern for the Jakarta metropolitan area with a long river basin crossing several administrative jurisdictions. Previous studies have addressed the challenges of flood risk, but they have tended to overlook transboundary issues and power sharing. To tackle future flood events, this paper aims to unveil transboundary challenges and power sharing in flood management, learning from Ciliwung River. As the longest river basin crossing cities and regencies of Greater Jakarta, the complexity of Ciliwung flood risk management was driven by flood variables triggered not only by natural, physical, and socioeconomic factors, but also by transboundary challenges and power sharing. A total of 13 significant transboundary flood drivers were identified from the literature, policy, and practices. Using Matrice d'Impacts Croisés Multiplication Appliquée á un Classement (MICMAC), a power–dependency model, several strategic key flood drivers were further recognized based on key stakeholders' perspectives obtained from in-depth interviews and focus group discussions (FGDs). Findings of the study show that a lack of control of spatial plans and weak stakeholder coordination–cooperation are found to be the priority key flood drivers for risk reduction intervention. Finally, this study contributes to the literature on governance of flood risk management by emphasizing the need for a coordinated and integrated approach to mitigate flood risks that extend beyond administrative boundaries, enhancing overall resilience and sustainability.

Objective: Ficus septica is an Indonesian medicinal plant traditionally used to treat various illness, including cancer. The n-hexane insoluble fraction of the ethanolic extract of F. septica leaves (HIFFS) shows a potential anticancer activity against breast cancer cell line T47D. Considering that angiogenesis is a pivotal factor in malignant cancer growth, progression, and invasion, we aimed to investigate the antiangiogenic effect of HIFFS on chicken chorioallantoic membrane (CAM) induced by bFGF. We also evaluated tylophorine, the cytotoxic alkaloid of F. septica., Methods: Chicken CAM was used to assess the antiangiogenic effect. Fertilized chicken eggs were induced with basic fibroblast growth factor (bFGF) ex ovo. Prior to bFGF induction, HIFFS (2.33, 4.65, 6.98, and 9.30 μg/mL) or tylophorine (9.20 µM) was added (10 µL) to a paper disk and implanted to the CAM. After 48 h of incubation, each treatment group was photographed, and the number of new blood vessel was calculated and compared with that in the solvent-treated group to determine the antiangiogenic activity. Histology of the CAM was evaluated after hematoxylin-eosin and Mallory acid fuchsin staining., Results: We found that HIFFS at low concentrations (2.33, 4.65, 6.98, and 9.30 μg/mL) inhibited angiogenesis activity (31.87, 41.99, 53.65, and 70.08, respectively) in chicken CAM induced by bFGF. Tylophorine (9.20 µM) also showed similar antiangiogenesis activity in the same model. Histopathology analysis revealed that HIFFS and tylophorine reduced the number of new blood vessels in CAM induced by bFGF., Conclusion: HIFFS and tylophorine showed antiangiogenic effect on chicken CAM induced by bFGF. This finding emphasized the potential of F. septica as a candidate anticancer agent.