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1. DIAGNOSTIC UTILITY OF ALDEHYDE DEGRADATION DEFICIENCY SYNDROME USING PROTEOMIC ANALYSIS

Author

M. Wakamatsu, H. Muramatsu, H. Sato, M. Ishikawa, D. Nakajima, R. Konno, Y. Kawashima, M. Hamada, Y. Okuno, O. Ohara, and Y. Takahashi

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Introduction: Inherited bone marrow failure syndrome (IBMFS) is characterized by a heterogeneous group of disorders with marked cytopenia in one hematopoietic cell lineage. Aldehyde Degradation Deficiency Syndrome (ADDS) is one of the newly discovered IBMFS, caused by a combined deficiency of ADH5 and ALDH2, which are important for the degradation of endogenously produced formaldehyde. Here, we utilized recent technological advances in data-independent proteomic analysis to establish a diagnostic testing for IBMFS, including ADDS. Methods: We performed a multi-omics analysis of in-depth proteomic analysis, targeted capture DNA sequencing, and RNA sequencing among patients with IBMFS. Results: In-depth non-targeted proteomic analysis was performed on 74 samples obtained from 60 patients with IBMFS and 14 healthy controls. We identified eight independent proteomic clusters (C1-C8), with ribosome pathway-related proteins specifically downregulated in C1 and C2, enriched for Diamond-Blackfan anemia and Schwachman-Diamond syndrome, respectively. In the 74 samples, four patients with ADDS showed significantly reduced ADH5 protein expression, whereas the remaining samples showed normal expression. To provide a large-scale rapid screening system in a practical clinical setting, targeted proteomic analysis was performed using a small panel, including ADH5 proteins, in a developmental cohort of 417 samples with hematological malignancies and healthy controls. ADH5 protein expression levels were significantly reduced in ADDS, and its sensitivity and specificity values were 100.0% and 97.5%, respectively. Conclusions: We have performed the first integrated multi-omics analysis for IBMFS, and demonstrated that clinical applications of targeted proteomic assays would be useful in diagnosing for IBMFS, including ADDS.

Published
2024
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2. Hypernuclear production cross section in the reaction of 6Li + 12C at 2A GeV

Author

C. Rappold, T.R. Saito, O. Bertini, S. Bianchin, V. Bozkurt, E. Kim, M. Kavatsyuk, Y. Ma, F. Maas, S. Minami, D. Nakajima, B. Özel-Tashenov, K. Yoshida, P. Achenbach, S. Ajimura, T. Aumann, C. Ayerbe Gayoso, H.C. Bhang, C. Caesar, S. Erturk, T. Fukuda, B. Göküzüm, E. Guliev, J. Hoffmann, G. Ickert, Z.S. Ketenci, D. Khaneft, M. Kim, S. Kim, K. Koch, N. Kurz, A. Le Fèvre, Y. Mizoi, L. Nungesser, W. Ott, J. Pochodzalla, A. Sakaguchi, C.J. Schmidt, M. Sekimoto, H. Simon, T. Takahashi, G.J. Tambave, H. Tamura, W. Trautmann, S. Voltz, and C.J. Yoon

Subjects
Hypernuclei, Production cross section, Yield ratio, Relativistic energy, Heavy ion collision, Physics, QC1-999
Abstract

Hypernuclear production cross sections have been deduced for the first time with induced reaction of heavy ion beam on fixed target and by means of the invariant mass method by the HypHI Collaboration exploiting the reaction of 6Li + 12C at 2A GeV or sNN=2.70 GeV. A production cross section of 3.9±1.4 μb for 3ΛH and of 3.1±1.0 μb for 4ΛH respectively in the projectile rapidity region was inferred as well as the total production cross section of the Λ hyperon was measured and found to be equal to 1.7±0.8 mb. A global fit based on a Bayesian approach was performed in order to include and propagate statistical and systematic uncertainties. Production ratios of 3ΛH/4ΛH, 3ΛH/Λ and 4ΛH/Λ were included in the inference procedure. The strangeness population factors S3 and S4 of 3ΛH and 4ΛH respectively were extracted. In addition, the multiplicities of the Λ hyperon, 3ΛH, and 4ΛH together with the rapidity and transversal momentum density distributions of the observed hypernuclei were extracted and reported.

Published
2015
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3. Conversion Gain Enhancement of a UTC-PD-Integrated HEMT Photonic Double-Mixer by High-Intensity Optical Subcarrier Signal

Author

D. Nakajima, K. Nishimura, M. Watanabe, T. T. Lin, K. Kasai, M. Yoshida, T. Suemitsu, T. Otsuji, and A. Satou

Abstract

We experimentally investigate the effect of high-intensity subcarrier signal input to the UTC-PD-integrated HEMT working for optical-to-wireless carrier frequency down-conversion on enhancement of its double-mixing conversion gain. The fabricated UTC-PD-integrated HEMT demonstrated the linear increase in the conversion gain by up to +7 dB with increasing the subcarrier signal intensity without saturation, and the conversion gain enhancement of +6.8 dB from -51.0 dB to -44.2 dB was achieved.

Published
2023

10. Optical-to-Wireless Carrier Frequency Down-Conversion by UTC-PD-Integrated HEMT: Dependence of Conversion Gain on UTC-PD Mesa Size

Author

Kazuki Nishimura, D. Nakajima, Tetsuya Suemitsu, Taiichi Otsuji, Akira Satou, Tomotaka Hosotani, and Katsumi Iwatsuki

Subjects
Materials science, business.industry, Transistor, High-electron-mobility transistor, Subcarrier, Photodiode, law.invention, Photomixing, Optical Carrier transmission rates, law, Optoelectronics, Radio frequency, Photonics, business
Abstract

To realize future ultra-broadband ubiquitous, resilient 6G/7G communication networks, the seamless, transparent linkage between optical and wireless networks is required [1] . We have studied the so-called photonic double-mixing functionality of transistors as a candidate of an efficient carrier frequency down-converter [2] . Its down-conversion process consists of photomixing of an optical carrier and subcarrier signals, generating the difference-frequency beat-note of the MMW/THz data signal, and RF mixing of the beat-note MMW/THz data and LO signals, generating an IF data signal. Recently, we have developed a MMW/THz carrier frequency down-converter based on an InGaAs-channel high-electron-mobility transistor (HEMT) with the uni-traveling-carrier photodiode (UTC-PD) structure (UTC-PD-integrated HEMT, see Fig. 1(a) ), demonstrating the significant enhancement of its double-mixing conversion gain by over 34 dB from that of a standard HEMT [3] . The conversion gain of the UTC-PD-integrated HEMT depends on various material and geometrical parameters through cutoff frequencies of the UTC-PD and HEMT, photoabsorption efficiency of the UTC-PD, etc. with complicated trade-off relations, so that the comprehensive device design principles are to be developed. In this work, we studied the scaling rule of the conversion gain on UTC-PD mesa size, and experimentally revealed the conversion gain increases with decreasing the mesa size up to the diffraction limit.

Published
2021

11. Donor prone positioning protects lungs from injury during warm ischemia

Author

Manyin Chen, C. Summers, L. Caldarone, Aadil Ali, T. Kanou, Shaf Keshavjee, Khaled Ramadan, Mingyao Liu, Yu Zhang, M. Galasso, R. Qaqish, Marcelo Cypel, M. Pipkin, Harley Chan, Thomas K. Waddell, Yohei Taniguchi, Y. Watanabe, D. Nakajima, Tatsuaki Watanabe, and Lorenzo Del Sorbo

Subjects
Extracorporeal Circulation, Supine position, Swine, Inflammation, 030230 surgery, 03 medical and health sciences, 0302 clinical medicine, Prone Position, medicine, Animals, Immunology and Allergy, Pharmacology (medical), Warm Ischemia, Asystole, Lung, Transplantation, business.industry, Organ Preservation, respiratory system, medicine.disease, Warm ischemia, Circulatory death, Tissue Donors, respiratory tract diseases, Death, Prone position, medicine.anatomical_structure, Reperfusion Injury, Anesthesia, Breathing, medicine.symptom, business, Lung Transplantation
Abstract

A large proportion of controlled donation after circulatory death (cDCD) donor lungs are declined because cardiac arrest does not occur within a suitable time after the withdrawal of life-sustaining therapy. Improved strategies to preserve lungs after asystole may allow the recovery team to arrive after death actually occurs and enable the recovery of lungs from more cDCD donors. The aim of this study was to determine the effect of donor positioning on the quality of lung preservation after cardiac arrest in a cDCD model. Cardiac arrest was induced by withdrawal of ventilation under anesthesia in pigs. After asystole, animals were divided into 2 groups based on body positioning (supine or prone). All animals were subjected to 3 hours of warm ischemia. After the observation period, donor lungs were explanted and preserved at 4°C for 6 hours, followed by 6 hours of physiologic and biological lung assessment under normothermic ex vivo lung perfusion. Donor lungs from the prone group displayed significantly greater quality as reflected by better function during ex vivo lung perfusion, less edema formation, less cell death, and decreased inflammation compared with the supine group. A simple maneuver of donor prone positioning after cardiac arrest significantly improves lung graft preservation and function.

Published
2019

12. The Stereoscopic Analog Trigger of the MAGIC Telescopes

Author

R. Maier, Takashi Saito, Derek Strom, S. Metz, D. Corti, M. Shayduk, T. Schweizer, R. Mirzoyan, J. R. Garcia, D. Häfner, S. Tran, D. Nakajima, Francesco Dazzi, G. Ceribella, Mosè Mariotti, A. Dettlaff, Martin Will, Masahiro Teshima, D. Herranz, Julian Sitarek, and M. Lopez-Moya

Subjects
Physics, Nuclear and High Energy Physics, Photon, business.industry, Astrophysics::High Energy Astrophysical Phenomena, Night sky, Astrophysics::Instrumentation and Methods for Astrophysics, Photodetector, law.invention, Telescope, Data acquisition, Optics, Nuclear Energy and Engineering, law, Física nuclear, MAGIC (telescope), Electrical and Electronic Engineering, Photonics, business, Cherenkov radiation
Abstract

The current generation of ground-based imaging atmospheric Cherenkov telescopes (IACTs) operate in the very-high-energy (VHE) domain from similar to 100 GeV to similar to 100 TeV. They use electronic digital trigger systems to discern the Cherenkov light flashes emitted by extensive air showers (EASs), from the overwhelming light of the night sky (LoNS) background. Near the telescope energy threshold, the number of emitted Cherenkov photons by gamma-ray-induced EASs is comparable to the fluctuations of the LoNS and the photon distribution at the Cherenkov-imaging camera plane becomes patchy. This results in a severe loss of effectiveness of the digital triggers based on combinatorial logic of thresholded signals. A stereoscopic analog trigger system has been developed for improving the detection capabilities of the Major Atmospheric Gamma-ray Imaging Cherenkov (MAGIC) telescopes at the lowest energies. It is based on the analog sum of the photosensor electrical signals. In this article, the architectural design, technical performances, and configuration of this stereoscopic analog trigger, dubbed "Sum-Trigger-II," are described.

Published
2021

18. Cytomegalovirus Infection After Lung Transplantation

Author

H. Kayawake, S. Tanaka, Y. Yamada, Y. Yutaka, A. Ohsumi, D. Nakajima, M. Hamaji, M. Nagao, and H. Date

Subjects
Pulmonary and Respiratory Medicine, Transplantation, Surgery, Cardiology and Cardiovascular Medicine
Published
2022

20. Pig lung transplant survival model

Author

Marcelo Cypel, Shaf Keshavjee, Jonathan C. Yeung, Mingyao Liu, D. Nakajima, A. Mariscal, L. Caldarone, Jussi Tikkanen, and Manyin Chen

Subjects
0301 basic medicine, medicine.medical_specialty, Swine, medicine.medical_treatment, Acute Lung Injury, Ischemia, Primary Graft Dysfunction, 030230 surgery, Lung injury, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, medicine, Animals, Lung transplantation, Survival analysis, Lung, business.industry, Critical factors, respiratory system, medicine.disease, Survival Analysis, Surgery, surgical procedures, operative, 030104 developmental biology, medicine.anatomical_structure, Models, Animal, business, Reperfusion injury, Lung Transplantation
Abstract

Although lung transplant is a life-saving therapy for some patients, primary graft dysfunction (PGD) is a leading cause of mortality and morbidity soon after a transplant. Ischemia reperfusion injury is known to be one of the most critical factors in PGD development. PGD is by definition an acute lung injury syndrome that occurs during the first 3 d following lung transplantation. To successfully translate laboratory discoveries to clinical practice, a reliable and practical large animal model is critical. This protocol describes a surgical technique for swine lung transplantation and postoperative management for a further 3 d post transplant. The protocol includes the background and rationale, required supplies, and a detailed description of the donor operation, transplant surgery, postoperative care, and sacrifice surgery. A pig lung transplant model is reliably produced in which the recipients survive for 3 d post transplant. This 3-d survival model can be used by lung transplant researchers to assess the development of PGD and to test therapeutic strategies targeting PGD. In total, the protocol requires 5 h for the surgeries, plus ~2 h in total for the postoperative care.

Published
2018

21. A technique for estimating the absolute gain of a photomultiplier tube

Author

Hideaki Katagiri, S. Gunji, Tokonatsu Yamamoto, T. Saito, Daniel Mazin, Yukikatsu Terada, J. Takeda, D. Nakajima, Aya Bamba, Takeshi Nakamori, Yusuke Konno, Tatsuo Yoshida, Y. Inome, S. Yoshii, Razmik Mirzoyan, Soki Sakurai, Hideyuki Ohoka, J. Kushida, K. Nishijima, Masahiro Teshima, D. Hadasch, T. Nagayoshi, M. Takahashi, S. Mashuda, S. Nozaki, M. Hayashida, Hidetoshi Kubo, Fuyuki Tokanai, and Reiko Orito

Subjects
Nuclear and High Energy Physics, Photomultiplier, Physics - Instrumentation and Detectors, Photon, Physics::Instrumentation and Detectors, FOS: Physical sciences, Poisson distribution, 01 natural sciences, Signal, Absolute gain, symbols.namesake, Optics, 0103 physical sciences, Physics::Atomic and Molecular Clusters, Physics::Atomic Physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, Instrumentation, Physics, 010308 nuclear & particles physics, business.industry, Noise (signal processing), Instrumentation and Detectors (physics.ins-det), Photoelectric effect, Amplification factor, symbols, Astrophysics - Instrumentation and Methods for Astrophysics, business
Abstract

Detection of low-intensity light relies on the conversion of photons to photoelectrons, which are then multiplied and detected as an electrical signal. To measure the actual intensity of the light, one must know the factor by which the photoelectrons have been multiplied. To obtain this amplification factor, we have developed a procedure for estimating precisely the signal caused by a single photoelectron. The method utilizes the fact that the photoelectrons conform to a Poisson distribution. The average signal produced by a single photoelectron can then be estimated from the number of noise events, without requiring analysis of the distribution of the signal produced by a single photoelectron. The signal produced by one or more photoelectrons can be estimated experimentally without any assumptions. This technique, and an example of the analysis of a signal from a photomultiplier tube, are described in this study., Comment: 18 pages, 6 figures

Published
2018

22. α 1 -Anti-trypsin improves function of porcine donor lungs during ex-vivo lung perfusion

Author

Jussi Tikkanen, Marcelo Cypel, Feng Tian, Zhe Wang, Lei Ding, Huiqing Lin, Shaf Keshavjee, Hei Yu Andrew Cheung, David M. Hwang, Mingyao Liu, Manyin Chen, A. Mariscal, and D. Nakajima

Subjects
0301 basic medicine, Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, medicine.medical_treatment, Inflammation, 030230 surgery, Pulmonary compliance, Lung injury, 03 medical and health sciences, 0302 clinical medicine, medicine.artery, medicine, Lung transplantation, Transplantation, Lung, business.industry, respiratory system, Pulmonary edema, medicine.disease, respiratory tract diseases, 030104 developmental biology, medicine.anatomical_structure, Anesthesia, Pulmonary artery, Vascular resistance, Surgery, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract

Background Ex-vivo lung perfusion (EVLP), a technique for donor lung assessment, also represents a platform for donor lung repair and immunomodulation. α 1 -Anti-trypsin (A1AT), a medication used to treat emphysema in A1AT-deficient patients, has anti-inflammatory properties and has been shown to attenuate ischemia–reperfusion injury in rat and pig lung transplants . The objective of this study was to determine whether administration of A1AT during EVLP can improve donor lung quality after prolonged hypothermic preservation. Methods Pig donor lungs were retrieved, preserved at 4°C for 24 hours, and then subjected to normothermic EVLP for 12 hours using the Toronto protocol. The treatment group (n = 6) received 3 mg/ml A1AT (Zemaira) in the EVLP perfusate, acellular Steen solution. The control group (n = 6) was perfused with Steen solution only. Physiologic functions and gas exchange were measured hourly. Pulmonary edema, lung injury, apoptosis and inflammatory mediators were evaluated in lung tissues and perfusate. Results A1AT treatment significantly reduced pulmonary arterial pressure , pulmonary vascular resistance and airway pressure changes from the baseline when compared with controls. A1AT treatment significantly improved both dynamic and static pulmonary compliance , and change in partial pressure of oxygen (ΔPO 2 ) between the left atrium and the pulmonary artery. Furthermore, A1AT treatment also significantly reduced pulmonary edema (wet-to-dry ratio), pulmonary cell apoptosis and pro-inflammatory cytokine levels (interleukin-1α and -8) in the perfusate. Conclusion Treatment of 24-hour-preserved pig donor lungs with A1AT during EVLP resulted in improved physiologic function, reduced pulmonary edema and inflammation and decreased cell death. Our findings suggest that treatment of donor lungs during EVLP with A1AT is a promising strategy to attenuate early lung injury and improve donor lung function before lung transplantation.

Published
2018

23. Evaluation of novel PMTs of worldwide best parameters for the CTA project

Author

Tokonatsu Yamamoto, J. Hose, T. Toyama, D. Müller, Masahiro Teshima, U. Menzel, M. Takahashi, D. Nakajima, and Razmik Mirzoyan

Subjects
Physics, Nuclear and High Energy Physics, Photomultiplier, 010308 nuclear & particles physics, business.industry, Detector, Dynode, Cherenkov Telescope Array, 01 natural sciences, Particle detector, Optics, 0103 physical sciences, Quantum efficiency, Photonics, business, 010303 astronomy & astrophysics, Instrumentation, Cherenkov radiation
Abstract

Photomultiplier Tubes (PMT) are the most widespread detectors for measuring fast and faint light signals. About six years ago, we started an improvement program for the PMT candidates for the Cherenkov Telescope Array (CTA) project in cooperation with the companies Hamamatsu Photonics K.K. (Japan) and Electron Tubes Enterprises Ltd. (England). CTA is the next major Imaging Atmospheric Cherenkov Telescopes array for ground-based high energy gamma-ray astrophysics. A total of ∼ 100 telescopes of sizes of 23 m, 12 m and 4 m in diameter will be built in northern and southern hemispheres. For CTA we need PMTs with the highest quantum efficiency and photoelectron collection efficiency, short pulse width of a few ns, low transit time spread and very low afterpulsing. The manufacturers were able to produce 1.5′ PMTs of enhanced peak quantum efficiency of ∼ 40 % . These collect up to 95–98% of photoelectrons onto the first dynode for the wavelengths ≥ 400 nm . A pulse width of ≤ 3 ns has been achieved at the selected operational gain of 40k. The afterpulsing for a threshold of ≥ 4 photoelectrons is dramatically reduced, down to the level of 0.02%. We will report on the measurements of 1.5′ PMTs from Hamamatsu and Electron Tubes Enterprises as candidate PMTs for the CTA project. The novel 1.5′ PMTs have the worldwide best parameters.

Published
2017

24. Donor bronchial wash bile acid and suitability of donor lungs for transplantation

Author

Mingyao Liu, D. Nakajima, Marcelo Cypel, Shaf Keshavjee, and T. Martinu

Subjects
Pulmonary and Respiratory Medicine, Transplantation, medicine.medical_specialty, Bile acid, medicine.drug_class, business.industry, 030204 cardiovascular system & hematology, Bronchial wash, Gastroenterology, Donor lungs, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Surgery, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business
Published
2018

25. Mesenchymal stromal cell therapy during ex vivo lung perfusion ameliorates ischemia-reperfusion injury in lung transplantation

Author

David M. Hwang, Thomas K. Waddell, Akihiro Ohsumi, R. Coutinho, Shaf Keshavjee, John E. Davies, Pierre Mordant, Tereza Martinu, M. Pipkin, Stephen C. Juvet, Tomohito Saito, Manyin Chen, L. Caldarone, Marcelo Cypel, Mingyao Liu, Y. Watanabe, T. Kanou, Rohin K. Iyer, D. Nakajima, and Ryan Lam

Subjects
0301 basic medicine, Pulmonary and Respiratory Medicine, Male, Pathology, medicine.medical_specialty, Swine, medicine.medical_treatment, Cold storage, Lung injury, Mesenchymal Stem Cell Transplantation, 03 medical and health sciences, Random Allocation, 0302 clinical medicine, medicine, Lung transplantation, Animals, Lung, Transplantation, business.industry, Mesenchymal stem cell, medicine.disease, Perfusion, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Reperfusion Injury, Surgery, Hepatocyte growth factor, Cardiology and Cardiovascular Medicine, business, Reperfusion injury, medicine.drug, Lung Transplantation
Abstract

BACKGROUND The application of mesenchymal stromal cell (MSC)–based therapy during ex vivo lung perfusion (EVLP) could repair injured donor lungs before transplantation. The aim of this study was to determine the efficacy of MSC therapy performed during EVLP on ischemia-reperfusion injury using a pig lung transplant model. METHODS Following 24 hours of cold storage, pig lungs were randomly assigned to 2 groups (n = 6 each), the control group without MSC vs the MSC group, where 5 × 106 cells/kg MSCs were delivered through the pulmonary artery during EVLP. After 12 hours of EVLP, followed by a 1-hour second cold preservation period, the left lung was transplanted and reperfused for 4 hours. RESULTS EVLP perfusate hepatocyte growth factor (HGF) level at 12 hours was significantly elevated in the MSC group compared with the control and was associated with a significant decrease in cell death markers, cleaved caspase-3 and terminal deoxynucleotidyl transferase dUTP nick end labeling–positive cells, in the MSC group. The MSC group showed significantly lower interleukin (IL)-18 and interferon gamma levels and a significantly higher IL-4 level in lung tissue at 12 hours of EVLP than the control group. After transplantation, the MSC group showed a significant increase in lung tissue HGF level compared with the control group, associated with a significantly reduced lung tissue wet-to-dry weight ratio. Lung tissue tumor necrosis factor-α level and pathological acute lung injury score were significantly lower in the MSC group than the control group. CONCLUSIONS The administration of MSCs ameliorated ischemic injury in donor lungs during EVLP and attenuated the subsequent ischemia-reperfusion injury after transplantation.

Published
2019

26. Mesenchymal stem cell treatment is associated with decreased perfusate concentration of interleukin-8 during ex vivo perfusion of donor lungs after 18-hour preservation

Author

Thomas K. Waddell, R. Coutinho, Pierre Mordant, Ilker Iskender, John E. Davies, L. Maahs, Rohin K. Iyer, Marcelo Cypel, Mingyao Liu, D. Nakajima, P. Behrens, R. Kalaf, and Shaf Keshavjee

Subjects
Vascular Endothelial Growth Factor A, 0301 basic medicine, Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Swine, medicine.medical_treatment, 030204 cardiovascular system & hematology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine.artery, medicine, Animals, Lung transplantation, Lung, Transplantation, business.industry, Interleukin-8, Mesenchymal stem cell, Mesenchymal Stem Cells, Perfusion, Vascular endothelial growth factor, 030104 developmental biology, medicine.anatomical_structure, chemistry, Pulmonary artery, Surgery, Cardiology and Cardiovascular Medicine, business, Ex vivo, Lung Transplantation
Abstract

Background Ex vivo lung perfusion (EVLP) presents a unique therapeutic opportunity to administer mesenchymal stromal cells (MSCs) to lung grafts before transplantation. We sought to determine the optimal route and dose of viable human umbilical cord–derived MSCs to be delivered into ex vivo–perfused damaged swine lungs, and to measure their effect on concentration of growth factors and inflammatory mediators. Methods Pig lungs were conventionally retrieved, cold preserved for 18 hours, and perfused normothermically ex vivo for 12 hours. Physiologic data were recorded. No cells were administered to a control group of animals ( n = 5). To examine the routes of administration, lungs were administered 50 × 10 6 MSCs endobronchially ( n = 3) or via the pulmonary artery ( n = 3). To determine the doses, a dose-escalation study was performed wherein lungs were administered 50 × 10 6 ( n = 3), 150 × 10 6 ( n = 5) and 300 × 10 6 ( n = 3) MSCs via the pulmonary artery. Concentrations of human growth factors and pig cytokines were measured in lung biopsies and perfusate. Results Intravascular administration of 50 × 10 6 MSCs was associated with significant and sustained retention of MSCs in lung parenchyma, whereas intrabronchial administration was not. Intravascular administration of 150 × 10 6 MSCs was the optimal tolerated dose and was associated with increased concentrations of human vascular endothelial growth factor (VEGF) in lung biopsies and decreased concentrations of pig interleukin-8 (IL-8) in the perfusate during 12 hours of EVLP. Conclusions Intravascular delivery of 150 × 10 6 MSCs showed preferred outcome compared with intrabronchial delivery to damaged lungs perfused ex vivo. The method was well tolerated and associated with an increased concentration of human VEGF in the lung tissue and a decreased concentration of pig IL-8 in the perfusate.

Published
2016

27. Human α1-antitrypsin improves early post-transplant lung function: Pre-clinical studies in a pig lung transplant model

Author

Jin Sakamoto, Thomas K. Waddell, Marcelo Cypel, Hyunhee Kim, David M. Hwang, Huiqing Lin, Ilker Iskender, D. Nakajima, Shaf Keshavjee, Manyin Chen, Mingyao Liu, Z. Guan, and Lorenzo Del Sorbo

Subjects
0301 basic medicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Pathology, Swine, medicine.medical_treatment, Antithrombin III, Urology, Primary Graft Dysfunction, 030204 cardiovascular system & hematology, Lung injury, Pulmonary compliance, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, Lung transplantation, Lung, Transplantation, business.industry, Pulmonary edema, medicine.disease, Rats, Clinical trial, 030104 developmental biology, medicine.anatomical_structure, Reperfusion Injury, Surgery, Cardiology and Cardiovascular Medicine, business, Reperfusion injury, Lung Transplantation, Peptide Hydrolases
Abstract

Background The translation of novel drugs in lung transplantation is challenged by different physiologic conditions between small animals and humans. Large-animal models provide important pre-clinical evidence and the next step that best informs clinical trials. In the present study, we used a pig lung transplant model to determine whether human α 1 -antitrypsin (A1AT), a medication shown to prevent pulmonary ischemia-reperfusion injury in rats, could attenuate reperfusion injury after prolonged hypothermic preservation in a large-animal lung transplant model. Methods Donor lungs were preserved for 24 hours at 4°C, followed by lung transplantation. In a randomized and blinded fashion, intravenous A1AT (240 mg/kg; n = 5) or human albumin ( n = 5) was administered to the recipient before reperfusion. Allograft gas exchange function and lung mechanics were monitored during a 4-hour reperfusion period. Microscopic lung injury, inflammatory response, coagulation activity, and cell death were assessed. Results Pulmonary gas exchange was significantly better during the 4-hour reperfusion period in the A1AT group. Treatment with A1AT improved static pulmonary compliance and significantly reduced pulmonary edema and lung permeability. A1AT treatment inhibited inflammatory mediators in the circulation, with reduced activation of nuclear factor-κB and inflammasome, reduced formation of thrombin-antithrombin complex in plasma, and reduced apoptosis in the allografts. Conclusions Administration of human A1AT before reperfusion in recipients improved immediate post-transplant lung function in pigs. A large-animal survival model should be considered to support further advancement toward a clinical trial of A1AT to prevent primary graft dysfunction in lung transplantation.

Published
2016

28. MAGIC upper limits on the GRB 090102 afterglow

Author

M. Gaug, Elisa Bernardini, Gianluca Giavitto, A. González Muñoz, C. Delgado Mendez, Victor Stamatescu, T. Schweizer, A. De Angelis, Mosè Mariotti, A.-K. Overkemping, D. Dominis Prester, Robert Wagner, L. A. Antonelli, Julian Sitarek, Saverio Lombardi, M. L. Knoetig, P. Antoranz, J. Hose, Natalia Lewandowska, T. Toyama, A. Sillanpää, Nikola Godinovic, Takashi Saito, P. Temnikov, Benito Marcote, Abelardo Moralejo, A. La Barbera, Fabrizio Tavecchio, M. V. Fonseca, A. Bouvier, J. Moldón, D. Garrido Terrats, Konstancja Satalecka, Ll. Font, Reiko Orito, Francisco Prada, W. Idec, Julia Thaele, Michele Doro, M. Palatiello, Dario Hrupec, Jelena Aleksić, M. A. Lopez, E. Colombo, P. Da Vela, V. Scalzotto, Dominik Elsaesser, U. Barres de Almeida, A. Niedzwiecki, M. Doert, Damir Lelas, Fabio Zandanel, Ralph Bock, L. O. Takalo, K. Frantzen, Q. Weitzel, Tihomir Surić, M. Uellenbeck, David Paneque, Francesco Dazzi, Patrick Vogler, Hiroyasu Tajima, I. Snidaric, D. Carreto Fidalgo, Ana Babić, Dorota Sobczyńska, G. De Caneva, U. Menzel, M. Salvati, Stefano Ansoldi, S. Rügamer, Juan Abel Barrio, Riccardo Paoletti, Nina Nowak, Diego F. Torres, A. Herrero, Christian Fruck, S. Partini, M. Hayashida, Francesco Longo, E. Lorenz, S. Paiano, Kari Nilsson, Karl Mannheim, Nijil Mankuzhiyil, K. Berger, P. Munar-Adrover, I. Lozano, D. Hadasch, Giacomo Bonnoli, E. Prandini, J. M. Paredes, M. Garczarczyk, Antonio Stamerra, Silvia Preziuso, Marc Ribó, P. G. Prada Moroni, J. Kushida, Aldo Treves, Jose Luis Contreras, J. Krause, B. De Lotto, Masahiro Teshima, O. Tibolla, Juan Cortina, Martin Makariev, Oscar Blanch, Tomislav Terzić, A. Hadamek, J. Storz, Ivica Puljak, Alicia López-Oramas, Pierre Colin, J. Becerra González, Emanuele Paolo Farina, S. Bonnefoy, Aaron Dominguez, Mario Meucci, R. Mirzoyan, D. Eisenacher, E. Carmona, Daniel Ferenc, Thomas Bretz, S. N. Shore, Wlodek Bednarek, Alessandro Carosi, Ruben Lopez-Coto, Felix Spanier, D. Nakajima, C. Schultz, V. Scapin, Jose Miguel Miranda, F. Borracci, Wolfgang Rhode, Ignasi Reichardt, G. Maneva, R. Zanin, A. Saggion, Adrian Biland, J. Rico, R. Reinthal, L. Maraschi, Elina Lindfors, Daniel Mazin, K. Mallot, R. J. García López, Stefano Covino, S. Sun, Massimo Persic, A. Boller, L. Cossio, D. Tescaro, T. Krähenbühl, K. Saito, J. Masbou, M. I. Martínez, V. Kadenius, S. R. Gozzini, J. Rodriguez Garcia, Daniela Dorner, J., Aleksic, S., Ansoldi, L. A., Antonelli, P., Antoranz, A., Babic, U. B., de Almeida, J. A., Barrio, J. B., Gonzalez, W., Bednarek, K., Berger, E., Bernardini, A., Biland, O., Blanch, R. K., Bock, A., Boller, S., Bonnefoy, G., Bonnoli, F., Borracci, T., Bretz, E., Carmona, A., Carosi, D. C., Fidalgo, P., Colin, E., Colombo, J. L., Contrera, J., Cortina, L., Cossio, S., Covino, P., Da Vela, F., Dazzi, A., De Angeli, G., De Caneva, B., De Lotto, C. D., Mendez, M., Doert, A., Dominguez, D. D., Prester, D., Dorner, M., Doro, D., Eisenacher, D., Elsaesser, E., Farina, D., Ferenc, M. V., Fonseca, L., Font, K., Frantzen, C., Fruck, R. J. G., Lopez, M., Garczarczyk, D. G., Terrat, M., Gaug, G., Giavitto, N., Godinovic, A. G., Munoz, S. R., Gozzini, A., Hadamek, D., Hadasch, A., Herrero, J., Hose, D., Hrupec, W., Idec, V., Kadeniu, M. L., Knoetig, T., Krahenbuhl, J., Krause, J., Kushida, A. L., Barbera, D., Lela, N., Lewandowska, E., Lindfor, S., Lombardi, R., Lopez Coto, M., Lopez, A., Lopez Orama, E., Lorenz, I., Lozano, M., Makariev, K., Mallot, G., Maneva, N., Mankuzhiyil, K., Mannheim, L., Maraschi, B., Marcote, M., Mariotti, M., Martinez, J., Masbou, D., Mazin, U., Menzel, M., Meucci, J. M., Miranda, R., Mirzoyan, J., Moldon, A., Moralejo, P., Munar Adrover, D., Nakajima, A., Niedzwiecki, K., Nilsson, N., Nowak, R., Orito, A., Overkemping, S., Paiano, M., Palatiello, D., Paneque, R., Paoletti, J. M., Parede, S., Partini, M., Persic, F., Prada, P. G. P., Moroni, E., Prandini, S., Preziuso, I., Puljak, I., Reichardt, R., Reinthal, W., Rhode, M., Ribo, J., Rico, J. R., Garcia, S., Rugamer, A., Saggion, K., Saito, T., Saito, M., Salvati, K., Satalecka, V., Scalzotto, V., Scapin, C., Schultz, T., Schweizer, S. N., Shore, A., Sillanpaa, J., Sitarek, I., Snidaric, D., Sobczynska, F., Spanier, V., Stamatescu, A., Stamerra, J., Storz, S., Sun, T., Suric, L., Takalo, F., Tavecchio, P., Temnikov, T., Terzic, D., Tescaro, M., Teshima, J., Thaele, O., Tibolla, D. F., Torre, T., Toyama, A., Treve, M., Uellenbeck, P., Vogler, R. M., Wagner, Q., Weitzel, F., Zandanel, R., Zanin, A., Bouvier, M., Hayashida, H., Tajima, and Longo, Francesco

Subjects
Photon, General, Non-thermal - gamma-ray burst, Radiation mechanisms, Astrophysics::High Energy Astrophysical Phenomena, gamma-ray burst: general, Hadron, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, general [gamma-ray burst], 7. Clean energy, 01 natural sciences, law.invention, Telescope, law, 0103 physical sciences, MAGIC (telescope), 010306 general physics, 010303 astronomy & astrophysics, Cherenkov radiation, High Energy Astrophysical Phenomena (astro-ph.HE), astro-ph.HE, Physics, ta115, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Astronomy and Astrophysics, radiation mechanisms: non-thermal, non-thermal [radiation mechanisms], Afterglow, gamma-rays bursts: general, Space and Planetary Science, ddc:520, Electrónica, Física nuclear, Electricidad, Astrophysics - High Energy Astrophysical Phenomena, Gamma-ray burst, Fermi Gamma-ray Space Telescope
Abstract

Indications of a GeV component in the emission from GRBs are known since the EGRET observations during the 1990's and they have been confirmed by the data of the Fermi satellite. These results have, however, shown that our understanding of GRB physics is still unsatisfactory. The new generation of Cherenkov observatories and in particular the MAGIC telescope, allow for the first time the possibility to extend the measurement of GRBs from several tens up to hundreds of GeV energy range. Both leptonic and hadronic processes have been suggested to explain the possible GeV/TeV counterpart of GRBs. Observations with ground-based telescopes of very high energy photons (E>30 GeV) from these sources are going to play a key role in discriminating among the different proposed emission mechanisms, which are barely distinguishable at lower energies. MAGIC telescope observations of the GRB 090102 (z=1.547) field and Fermi Large Area Telescope (LAT) data in the same time interval are analysed to derive upper limits of the GeV/TeV emission. We compare these results to the expected emissions evaluated for different processes in the framework of a relativistic blast wave model for the afterglow. Simultaneous upper limits with Fermi and a Cherenkov telescope have been derived for this GRB observation. The results we obtained are compatible with the expected emission although the difficulties in predicting the HE and VHE emission for the afterglow of this event makes it difficult to draw firmer conclusions. Nonetheless, MAGIC sensitivity in the energy range of overlap with space-based instruments (above about 40 GeV) is about one order of magnitude better with respect to Fermi. This makes evident the constraining power of ground-based observations and shows that the MAGIC telescope has reached the required performance to make possible GRB multiwavelength studies in the very high energy range., 8 pages, 5 figures, 2 tables. Submitted to MNRAS

Published
2014

29. Ex Vivo Perfusion Treatment of Infection in Human Donor Lungs

Author

Marcelo Cypel, R. Bonato, V. Linacre, Tiago N. Machuca, Manyin Chen, R. Coutinho, Shaf Keshavjee, David M. Hwang, D. Nakajima, Tereza Martinu, K. Hashimoto, Sassan Azad, Shahid Husain, Thomas K. Waddell, Ilker Iskender, and Mingyao Liu

Subjects
Adult, Male, Extracorporeal Circulation, medicine.medical_specialty, Tissue and Organ Procurement, medicine.drug_class, medicine.medical_treatment, Antibiotics, 030204 cardiovascular system & hematology, 030230 surgery, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Anti-Infective Agents, Internal medicine, Bronchopneumonia, medicine, Humans, Immunology and Allergy, Lung transplantation, Pharmacology (medical), Lung, Transplantation, medicine.diagnostic_test, business.industry, Extracorporeal circulation, Middle Aged, respiratory system, Prognosis, Bacterial Load, Tissue Donors, respiratory tract diseases, 3. Good health, Perfusion, Bronchoalveolar lavage, medicine.anatomical_structure, Case-Control Studies, Immunology, Vancomycin, Female, business, Bronchoalveolar Lavage Fluid, Follow-Up Studies, Lung Transplantation, medicine.drug
Abstract

Ex vivo lung perfusion (EVLP) is a platform to treat infected donor lungs with antibiotic therapy before lung transplantation. Human donor lungs that were rejected for transplantation because of clinical concern regarding infection were randomly assigned to two groups. In the antibiotic group (n = 8), lungs underwent EVLP for 12 h with high-dose antibiotics (ciprofloxacin 400 mg or azithromycin 500 mg, vancomycin 15 mg/kg, and meropenem 2 g). In the control group (n = 7), lungs underwent EVLP for 12 h without antibiotics. A quantitative decrease in bacterial counts in bronchoalveolar lavage (BAL) was found in all antibiotic-treated cases but in only two control cases. Perfusate endotoxin levels at 12 h were significantly lower in the antibiotic group compared with the control group. EVLP with broad-spectrum antibiotic therapy significantly improved pulmonary oxygenation and compliance and reduced pulmonary vascular resistance. Perfusate endotoxin levels at 12 h were strongly correlated with levels of perfusates tumor necrosis factor α, IL-1β and macrophage inflammatory proteins 1α and 1β at 12 h. In conclusion, EVLP treatment of infected donor lungs with broad-spectrum antibiotics significantly reduced BAL bacterial counts and endotoxin levels and improved donor lung function.

Published
2016

30. Extension of donor lung preservation with hypothermic storage after normothermic ex vivo lung perfusion

Author

Manyin Chen, Shaf Keshavjee, K. Hashimoto, Jingu Lee, Hyunhee Kim, Pedro Reck dos Santos, Michael Kuan Yew Hsin, Constantine Harmantas, Ilker Iskender, Marcelo Cypel, Mingyao Liu, D. Nakajima, Jin Sakamoto, David M. Hwang, and Thomas K. Waddell

Subjects
Pulmonary and Respiratory Medicine, Extracorporeal Circulation, medicine.medical_specialty, Time Factors, Swine, medicine.medical_treatment, Organ Preservation Solutions, Respiratory physiology, 030204 cardiovascular system & hematology, 030230 surgery, Lung injury, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Lung transplantation, Transplantation, business.industry, Cold Ischemia, Ex vivo lung perfusion, Organ Preservation, Oxygenation, respiratory system, Surgery, Donor lungs, Perfusion, Disease Models, Animal, Reperfusion Injury, Anesthesia, Lung preservation, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies, Lung Transplantation
Abstract

Background Ex vivo lung perfusion (EVLP) allows normothermic evaluation and treatment of donor lungs not currently acceptable for transplant and improves organ use. Donor lungs undergo a period of cold preservation before (cold ischemic time [CIT]-1) and after (CIT-2) EVLP. We investigated the effect of an extended CIT-2 on lung function after transplantation. Methods Explanted pig lungs, preserved in low-potassium dextran flush (Perfadex) at 4°C for 10 hours, were subjected to 6 hours of EVLP. They were subsequently allocated to 2 groups: short CIT-2 (CIT-2 = 2 hours; n = 5), and long CIT-2 (CIT-2 = 10 hours; n = 5). In a control group ( n = 6), explanted lungs were placed in cold static preservation for 24 hours without EVLP. After the total preservation period, the left lung was transplanted in all groups. Results After 4 hours of reperfusion, oxygenation function, acute lung injury score, inflammatory markers, and cell death pathway markers were similar between short and long CIT-2 groups. Both EVLP groups fared significantly better than the control group in oxygenation function ( p Conclusions The intervention of EVLP improved lung function after transplantation, and this was not affected by a prolonged cold static preservation time after EVLP. These results provide the basis for a practical prolonged lung preservation strategy using a combination of cold and warm preservation techniques, which may improve lung transplantation logistics and outcomes.

Published
2016

32. Evaluation of the basic propertied of the novel 1.5 in. size PMTs from Hamamatsu Photonics and Electron Tubes Enterprises

Author

J. Hose, U. Menzel, Tokonatsu Yamamoto, Y. Hanabata, Masahiro Teshima, D. Nakajima, Razmik Mirzoyan, Takeshi Toyama, and M. Takahashi

Subjects
Physics, Nuclear and High Energy Physics, Photomultiplier, business.industry, Electron, Cherenkov Telescope Array, Cathode, law.invention, Optics, Upgrade, law, Quantum efficiency, Photonics, business, Instrumentation, Cherenkov radiation
Abstract

Currently the standard light sensors for Imaging Atmospheric Cherenkov Telescopes are the classical photo multiplier tubes that are using bialkali photocathodes. About 8 years ago we initiated an improvement program with the Photo Multiplier Tube manufacturers Hamamatsu in Japan, Electron Tubes Enterprises in England and Photonis in France for the needs of Imaging Atmospheric Cherenkov Telescopes. As a result, after about 40 years of “stagnation” of the peak Quantum Efficiency on the level of 25–27%, new PMTs appeared with a peak QE of 35%. These have got the name “super-bialkali”. The second significant upgrade has happened very recently, as a result of a dedicated improvement program for the candidate PMT for Cherenkov Telescope Array. The latter is going to be the next generation major instrument in the field of very high energy gamma astrophysics and will consist of over 100 telescopes of three different sizes of 23 m, 12 m and 4–7 m. Now PMTs with average peak Quantum Efficiency of approximately 40% became available. Also, the photo electron collection efficiency of the previous generation PMTs of 80–90% has been enhanced towards 95–98% for the new ones. The after-pulsing of novel PMTs has been reduced towards the level of 0.02% for the set threshold of 4 photo electrons. Hamamatsu produced the PMT R-12992-100 as the final version for Cherenkov Telescope Array project. Electron Tubes produced the latest PMT D569/3SA as intermediate version and will produce the final version in 2015. We will report on the PMT development work by the companies Electron Tubes Enterprises and Hamamatsu Photonics K.K., show the achieved results and the current status.

Published
2015

33. MAGIC detection of short-term variability of the high-peaked BL Lac object 1ES 0806+524

Author

A. De Angelis, A. Treves, Vitaly Neustroev, R. Zanin, Adrian Biland, J. Rico, G. Maneva, Dario Hrupec, Thomas Bretz, M. Palatiello, Dario Gasparrini, I. Lozano, M. A. Lopez, A. González Muñoz, Louis Antonelli, Walter Max-Moerbeck, Diego F. Torres, Jelena Aleksić, R. López-Coto, X. Paredes-Fortuny, A. Niedzwiecki, D. Nakajima, Julian Sitarek, Francesco Dazzi, A. Fernández-Barral, Patrick Vogler, P. Munar-Adrover, J. M. Paredes, J. Kushida, Jose Luis Contreras, Masahiro Teshima, Ivica Puljak, Filippo D'Ammando, Daniela Dorner, K. Mallot, Wolfgang Rhode, Pierre Colin, R. J. García López, Elina Lindfors, A. Sillanpää, Juan Abel Barrio, David Paneque, Juan Cortina, C. Fruck, M. Gaug, D. Fidalgo, T. Toyama, Antonio Stamerra, Daniel Mazin, Takashi Saito, J. Krause, W. Bednarek, J. Herrera, B. De Lotto, Fabrizio Tavecchio, Julia Thaele, S. N. Shore, K. Berger, Ll. Font, Koji Noda, Reiko Orito, Elisa Bernardini, J. Hose, I. Snidaric, J. L. Richards, D. Elsaesser, E. de Oña Wilhelmi, Francesco Longo, H. Takami, Abelardo Moralejo, K. Nishijima, F. Di Pierro, C. Delgado Mendez, D. Dominis Prester, T. Steinbring, Massimo Persic, Yusuke Konno, Juri Poutanen, E. Lorenz, M. Hayashida, Stefano Covino, G. De Caneva, M. V. Fonseca, Kari Nilsson, K. Kodani, Y. Hanabata, K. Saito, G. Bonnoli, Talvikki Hovatta, M. Will, Marc Ribó, D. Tescaro, P. Antoranz, Konstancja Satalecka, R. Reinthal, P. Temnikov, Michele Doro, M. L. Knoetig, S. Buson, Razmik Mirzoyan, Hidetoshi Kubo, P. G. Prada Moroni, D. Garrido Terrats, Damir Lelas, V. Scalzotto, Nikola Godinovic, Benito Marcote, Dorota Sobczyńska, Oscar Blanch, Ana Babić, P. Da Vela, Stefano Ansoldi, T. Schweizer, Riccardo Paoletti, E. Prandini, F. Borracci, Alessandro Carosi, D. Hadasch, Jose Miguel Miranda, C. Schultz, V. Scapin, Anthony C. S. Readhead, M. Strzys, L. Maraschi, B. Biasuzzi, Tomislav Terzić, D. Galindo, M. I. Martínez, P. Bangale, Sabrina Einecke, S. R. Gozzini, J. Rodriguez Garcia, M. Makariev, U. Menzel, W. Idec, E. Colombo, L. O. Takalo, Mosè Mariotti, A.-K. Overkemping, Saverio Lombardi, Hanna Kellermann, K. Frantzen, V. Kadenius, S. Bonnefoy, S. Paiano, Karl Mannheim, D. Eisenacher, E. Carmona, Markus Garczarczyk, Alicia López-Oramas, Natalia Lewandowska, A. La Barbera, M. Nievas Rosillo, J. Becerra González, Aalto-yliopisto, Aalto University, Aleksi , J., Ansoldi, Stefano, Antonelli, L. A., Antoranz, P., Babic, A., Bangale, P., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bernardini, E., Biasuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Carmona, E., Carosi, A., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Da Vela, P., Dazzi, F., De Angelis, A., De Caneva, G., De Lotto, B., de Ona Wilhelmi, E., Delgado Mendez, C., Di Pierro, F., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Eisenacher, D., Elsaesser, D., Fernandez Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C., Galindo, D., Garcia Lopez, R. J., Garczarczyk, M., Garrido Terrats, D., Gaug, M., Godinovi , N., Gonzalez Munoz, A., Gozzini, S. R., Hadasch, D., Hanabata, Y., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Idec, W., Kadenius, V., Kellermann, H., Knoetig, M. L., Kodani, K., Konno, Y., Krause, J., Kubo, H., Kushida, J., La Barbera, A., Lelas, D., Lewandowska, N., Lindfors, E., Lombardi, S., Longo, Francesco, Lopez, M., Lopez Coto, R., Lopez Oramas, A., Lorenz, E., Lozano, I., Makariev, M., Mallot, K., Maneva, G., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martinez, M., Mazin, D., Menzel, U., Miranda, J. M., Mirzoyan, R., Moralejo, A., Munar Adrover, P., Nakajima, D., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nilsson, K., Nishijima, K., Noda, K., Orito, R., Overkemping, A., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Paredes Fortuny, X., Persic, M., Poutanen, J., Prada Moroni, P. G., Prandini, E., Puljak, I., Reinthal, R., Rhode, W., Ribo, M., Rico, J., Rodriguez Garcia, J., Saito, T., Saito, K., Satalecka, K., Scalzotto, V., Scapin, V., Schultz, C., Schweizer, T., Shore, S. N., Sillanpaa, A., Sitarek, J., Snidaric, I., Sobczynska, D., Stamerra, A., Steinbring, T., Strzys, M., Takalo, L., Takami, H., Tavecchio, F., Temnikov, P., Terzi , T., Tescaro, D., Teshima, M., Thaele, J., Torres, D. F., Toyama, T., Treves, A., Vogler, P., Will, M., Zanin, R., Berger, K., Buson, S., D'Ammando, F., Gasparrini, D., Hovatta, T., Max Moerbeck, W., Readhead, A., and Richards, J.

Subjects
radiation mechanisms: non-thermal, galaxies: active, BL Lacertae objects: individual: 1ES 0806+524, galaxies: jets, gamma rays: galaxies, Astrophysics::High Energy Astrophysical Phenomena, astro-ph.GA, galaxies: active, jets [galaxies], Flux, FOS: Physical sciences, radiation mechanisms: non-thermal, BL Lacertae objects: individual: 1ES 0806+524, galaxies: jets, gamma rays: galaxies, individual: 1ES 0806+524 [BL Lacertae objects], Astrophysics, law.invention, law, MAGIC (telescope), Blazar, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), astro-ph.HE, ta115, ta213, Compton scattering, Astronomy, Astronomy and Astrophysics, non-thermal [radiation mechanisms], non-thermal, galaxies: active, BL Lacertae objects: individual: 1ES 0806+524, galaxies: jets, gamma rays: galaxies [radiation mechanisms], Astrophysics - Astrophysics of Galaxies, Galaxies: active, Galaxies: jets, Gamma rays: galaxies, Radiation mechanisms: non-thermal, Space and Planetary Science, Crab Nebula, Astrophysics of Galaxies (astro-ph.GA), active [galaxies], galaxies [gamma rays], ddc:520, Spectral energy distribution, Astrophysics - High Energy Astrophysical Phenomena, BL Lac object, Flare
Abstract

Monthly notices of the Royal Astronomical Society 451(1), 739 - 750 (2015). doi:10.1093/mnras/stv895, The high-frequency-peaked BL Lac (HBL) 1ES 0806+524 (z = 0.138) was discovered in very high energy (VHE) γ-rays in 2008. Until now, the broad-band spectrum of 1ES 0806+524 has been only poorly characterized, in particular at high energies. We analysed multiwavelength observations from γ-rays to radio performed from 2011 January to March, which were triggered by the high activity detected at optical frequencies. These observations constitute the most precise determination of the broad-band emission of 1ES 0806+524 to date. The stereoscopic Major Atmospheric Gamma-Ray Imaging Cherenkov (MAGIC) observations yielded a γ-ray signal above 250 GeV of (3.7 ± 0.7) per cent of the Crab Nebula flux with a statistical significance of 9.9σ. The multiwavelength observations showed significant variability in essentially all energy bands, including a VHE γ-ray flare that lasted less than one night, which provided unprecedented evidence for short-term variability in 1ES 0806+524. The spectrum of this flare is well described by a power law with a photon index of 2.97 ± 0.29 between ∼150 GeV and 1 TeV and an integral flux of (9.3 ± 1.9) per cent of the Crab nebula flux above 250 GeV. The spectrum during the non-flaring VHE activity is compatible with the only available VHE observation performed in 2008 with VERITAS when the source was in a low optical state. The broad-band spectral energy distribution can be described with a one-zone synchrotron self-Compton model with parameters typical for HBLs, indicating that 1ES 0806+524 is not substantially different from the HBLs previously detected., Published by Oxford Univ. Press, Oxford

Published
2015

34. Proton spectra from Non-Mesonic Weak Decay of p-shell Λ-hypernuclei and evidence for the two-nucleon induced process

Author

A. Andronenkov, F. L. Fabbri, Haruhiko Outa, V. Lenti, P. Genova, D. Calvo, Aldo Zenoni, Michiko Sekimoto, R. Wheadon, G. D'Erasmo, Tullio Bressani, N. Grion, Paolo Camerini, M. Palomba, O. Morra, E. M. Fiore, G. A. Beer, V. Lucherini, N. Mirfakhrai, A. Filippi, Michelangelo Agnello, O. Hartmann, F. De Mori, Akihiro Toyoda, G. Simonetti, Paola Gianotti, Luigi Benussi, D. Nakajima, Stefania Bufalino, E. Pace, M. Bertani, B. Dalena, Andrea Fontana, G. Garbarino, Tomofumi Maruta, A. Panzarasa, L. Busso, Paolo Montagna, Marco Bregant, A. Pantaleo, Rinaldo Rui, S. Marcello, S. Piano, V. Paticchio, F. Pompili, A. Feliciello, Germano Bonomi, Tomofumi Nagae, Hiroyuki Fujioka, Elena Botta, H. C. Bhang, M., Agnello, A., Andronenkov, G., Beer, L., Benussi, M., Bertani, H. C., Bhang, G., Bonomi, E., Botta, M., Bregant, T., Bressani, S., Bufalino, L., Busso, D., Calvo, Camerini, Paolo, B., Dalena, F., De Mori, G., D'Erasmo, F. L., Fabbri, A., Feliciello, A., Filippi, E. M., Fiore, A., Fontana, H., Fujioka, P., Genova, P., Gianotti, N., Grion, O., Hartmann, V., Lenti, V., Lucherini, S., Marcello, T., Maruta, N., Mirfakhrai, P., Montagna, O., Morra, T., Nagae, D., Nakajima, H., Outa, E., Pace, M., Palomba, A., Pantaleo, A., Panzarasa, V., Paticchio, S., Piano, F., Pompili, Rui, Rinaldo, M., Sekimoto, G., Simonetti, A., Toyoda, R., Wheadon, A., Zenoni, and G., Garbarino

Subjects
Mass number, Physics, Nuclear and High Energy Physics, Range (particle radiation), Proton, Branching fraction, Nuclear Theory, Shell (structure), FOS: Physical sciences, lambda hypernuclei, Kinetic energy, Spectral line, Nuclear physics, non-mesonic decay, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Atomic physics, Nucleon, Nuclear Experiment
Abstract

New spectra from the FINUDA experiment of the Non Mesonic Weak Decay (NMWD) proton kinetic energy for 9(Lambda)Be, 11(Lambda)B, 12(Lambda)C, 13(Lambda)C, 15 (Lambda)N and 16(Lambda)O are presented and discussed along with the published data on 5(Lambda)He and 7(Lambda)Li. Exploiting the large mass number range and the low energy threshold (15 MeV) for the proton detection of FINUDA, an evaluation of both Final State Interactions (FSI) and the two nucleon induced NMWD contributions to the decay process has been done. Based on this evaluation, a linear dependence of FSI on the hypernuclear mass number A is found and for the two nucleon stimulated decay rate the experimental value of Gamma2/Gammap=0.43+-0.25 is determined for the first time. A value for the two nucleon stimulated decay rate to the total decay rate Gamma2/GammaNMWD=0.24+-0.10 is also extracted., 11 pages and 2 figures

Published
2010

35. Study of two-body non-mesonic decays of light hypernuclei with FINUDA

Author

Haruhiko Outa, B. Dalena, Tullio Bressani, F. L. Fabbri, N. Mirfakhrai, Andrea Fontana, Germano Bonomi, F. Moia, Stefano Piano, G. Simonetti, Paolo Camerini, R. Wheadon, E. M. Fiore, D. Calvo, N. Grion, V. Paticchio, F. De Mori, P. Genova, Tomofumi Nagae, G. D'Erasmo, D. Nakajima, Luigi Benussi, B. H. Kang, Rinaldo Rui, S. Marcello, E. Botta, V. Lucherini, M. Bertani, O. Morra, A. Filippi, Akihiro Toyoda, Michelangelo Agnello, Stefania Bufalino, Marco Bregant, Paola Gianotti, H. C. Bhang, F. Pompili, A. Feliciello, Aldo Zenoni, L. Busso, A. Pantaleo, Tomofumi Maruta, Hiroyuki Fujioka, M., Agnello, L., Benussi, M., Bertani, H. C., Bhang, G., Bonomi, E., Botta, M., Bregant, T., Bressani, S., Bufalino, L., Busso, D., Calvo, Camerini, Paolo, B., Dalena, F., De Mori, G., D'Erasmo, F. L., Fabbri, A., Feliciello, A., Filippi, E. M., Fiore, A., Fontana, H., Fujioka, P., Genova, P., Gianotti, N., Grion, B., Kang, V., Lucherini, S., Marcello, T., Maruta, N., Mirfakhrai, F., Moia, O., Morra, T., Nagae, D., Nakajima, H., Outa, A., Pantaleo, V., Paticchio, S., Piano, F., Pompili, Rui, Rinaldo, G., Simonetti, A., Toyoda, R., Wheadon, and A., Zenoni

Subjects
Physics, Nuclear physics, Non Mesonic Weak Decay, Nuclear and High Energy Physics, hypernucleu, hypernucleus, non-mesonic decay, Light Hypernuclei, High Energy Physics::Experiment, Nuclear Experiment, Branching (polymer chemistry)
Abstract

The Non-Mesonic two-body decays He Λ 4 → d d , p t and He Λ 5 → d t have been studied by the FINUDA experiment. The branching ratios for these rare decay channels are given.

Published
2010

36. Development of a Hundred-Picoseconds Pulse Laser as a Calibration Source

Author

Tokonatsu Yamamoto, Masahiro Teshima, Y. Inome, D. Nakajima, H. Ohoka, and Razmik Mirzoyan

Subjects
Photon, Materials science, Laser diode, 010308 nuclear & particles physics, business.industry, Physics::Optics, 01 natural sciences, law.invention, Semiconductor laser theory, Pulsed laser deposition, Full width at half maximum, Optics, law, Picosecond, 0103 physical sciences, Calibration, Physics::Atomic Physics, business, Pulse-width modulation
Abstract

We have developed a pulse laser for a calibration of photon sensors used in a high energy experiments. The pulse width of the laser beam is 110 ps in full width at half maximum (FWHM) and its peak intensity is adjustable up to 100 mW. This pulse laser is composed of a simple electric circuit which generates short electric pulse and a laser diode. It is contained in a few cm aluminum case. Details of this pulse laser are reported in this contribution.

Published
2017

37. The role of biomechanical anatomical modeling via computed tomography for identification of restrictive allograft syndrome

Author

Kristy K. Brock, Pascal Salazar, Luigia D'Errico, Matthew Binnie, Tomohito Saito, D. Nakajima, Narinder Paul, M. Horie, Kazuhiro Yasufuku, Shaf Keshavjee, and Joanne Moseley

Subjects
Adult, Male, Models, Anatomic, Pathology, medicine.medical_specialty, Bronchiolitis obliterans, Computed tomography, Pilot Projects, Disease, 030230 surgery, Sensitivity and Specificity, 030218 nuclear medicine & medical imaging, Pulmonary function testing, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Transplantation, Homologous, In patient, Bronchiolitis Obliterans, Lung, Lung function, Qualitative Research, Aged, Retrospective Studies, Transplantation, medicine.diagnostic_test, business.industry, Retrospective cohort study, Syndrome, Middle Aged, medicine.disease, Biomechanical Phenomena, medicine.anatomical_structure, Chronic Disease, Female, Radiology, Primary Graft Dysfunction, business, Tomography, X-Ray Computed, Lung Transplantation
Abstract

Chronic lung allograft dysfunction (CLAD) reduces long-term graft survival. It is important to distinguish CLAD subtypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS) as RAS has a worse prognosis and accurate subtyping could facilitate targeted treatments. However, the current diagnosis of CLAD subtypes is based on pulmonary function test (PFT) results that reflect global estimates of lung function; anatomical modeling based on computed tomography (CT) has the potential to provide detailed analysis of global and regional lung function. The purpose of this study is to evaluate the utility of CT-based anatomical modeling for the identification of RAS. This retrospective study included 51 patients (CLAD: 17 BOS and 17 RAS, control: 17 No-CLAD). CT data were assessed using a biomechanical model-based platform (MORFEUS) to characterize changes in lung deformation between baseline and disease onset. Lung deformation demonstrated high sensitivity and specificity (>80%) in differentiating RAS from BOS (P

Published
2017

38. Very-high-energy gamma-ray observations of the Type Ia Supernova SN 2014J with the MAGIC telescopes

Author

K. Mallot, F. Di Pierro, Francesco Longo, R. J. García López, D. Hadasch, Daniela Dorner, U. Barres de Almeida, Damir Lelas, S. Paiano, Karl Mannheim, W. Idec, Mosè Mariotti, Dariusz Gora, Gaia Vanzo, D. Nakajima, D. Elsaesser, Dorota Sobczyńska, P. Da Vela, M. Gaug, Arka Chatterjee, R. Zanin, Adrian Biland, Saverio Lombardi, Abelardo Moralejo, Wlodek Bednarek, Alessandro Carosi, Max Ludwig Ahnen, J. Becerra González, M. Palatiello, M. Hayashida, Ruben Lopez-Coto, J. Herrera, D. Fidalgo, Martin Makariev, Pratik Majumdar, M. V. Fonseca, Massimo Persic, Alessio Berti, Marc Ribó, P. Bangale, Hidetoshi Kubo, E. Moretti, Alexander Hahn, Dario Hrupec, M. A. Lopez, Francesco Dazzi, A. Fernández-Barral, M. Vazquez Acosta, J. Rico, I. Reichardt, Rodolfo Carosi, Oscar Blanch, E. Colombo, P. Giammaria, P. Temnikov, Gareth Hughes, J. M. Paredes, L. Nogués, B. Biasuzzi, Koji Noda, Stefano Covino, U. Menzel, Antonio Stamerra, K. Kodani, L. O. Takalo, Elisa Bernardini, Kyoshi Nishijima, Nikola Godinovic, Benito Marcote, Jose Miguel Miranda, E. Prandini, L. Perri, Yusuke Konno, Diego F. Torres, M. Doert, M. H. Wu, L. A. Antonelli, M. I. Martínez, M. Garczarczyk, A. La Barbera, Marcel Strzys, S. Bonnefoy, Julian Sitarek, D. Eisenacher Glawion, X. Paredes-Fortuny, M. Peresano, D. Dominis Prester, Sabrina Einecke, B. De Lotto, Kari Nilsson, D. Tescaro, J. Hose, A. Niedzwiecki, C. Fruck, M. Engelkemeier, F. Borracci, M. Nievas Rosillo, M. Will, A. De Angelis, A. Treves, Vitaly Neustroev, R. Mirzoyan, T. Toyama, Fabrizio Tavecchio, T. Surić, J. R. Garcia, David Paneque, A. Sillanpää, Ll. Font, S. Schroeder, Giacomo Bonnoli, L. Maraschi, D. Guberman, D. Garrido Terrats, Ivica Puljak, Pierre Colin, I. Snidaric, V. Fallah Ramazani, Elina Lindfors, Takashi Saito, G. Maneva, J. Palacio, J. E. Ward, Masahiro Teshima, Daniel Mazin, Juan Abel Barrio, E. de Oña Wilhelmi, Ievgen Vovk, Aaron Dominguez, Stefano Ansoldi, P. G. Prada Moroni, T. Schweizer, Riccardo Paoletti, Tomislav Terzić, Marina Manganaro, Ana Babić, D. Galindo, B. Banerjee, C. Arcaro, Juri Poutanen, J. Kushida, G. Pedaletti, Thomas Bretz, Jose Luis Contreras, P. Antoranz, P. Cumani, Konstancja Satalecka, Michele Doro, Juan Cortina, Wolfgang Rhode, K. Frantzen, Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Antoranz, P., Arcaro, C., Babic, A., Banerjee, B., Bangale, P., Barres De Almeida, U., Barrio, J. A., Becerra González, J., Bednarek, W., Bernardini, E., Berti, Alessio, Biasuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Carosi, R., Carosi, A., Chatterjee, A., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Cumani, P., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., De Onã Wilhelmi, E., DI Pierro, F., Doert, M., Domã­nguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Eisenacher Glawion, D., Elsaesser, D., Engelkemeier, M., Fallah Ramazani, V., Fernández Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C, Galindo, D., Garciá López, R. J., Garczarczyk, M., Garrido Terrats, D., Gaug, M., Giammaria, P., Godinoviä , N., Gora, D., Guberman, D., Hadasch, D., Hahn, A., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Hughes, G., Idec, W., Kodani, K., Konno, Y., Kubo, H., Kushida, J., La Barbera, A., Lelas, D., Lindfors, E., Lombardi, S., Longo, Francesco, Lã³pez, M., López Coto, R., Majumdar, P., Makariev, M., Mallot, K., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martã­nez, M., Mazin, D., Menzel, U., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moretti, E., Nakajima, D., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nilsson, K., Nishijima, K., Noda, K., Noguã©s, L., Paiano, S., Palacio, J., Palatiello, Michele, Paneque, D., Paoletti, R., Paredes, J. M., Paredes Fortuny, X., Pedaletti, G., Peresano, M., Perri, L., Persic, M., Poutanen, J., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Reichardt, I., Rhode, W., Ribã³, M., Rico, J., Saito, T., Satalecka, K., Schroeder, S., Schweizer, T., Sillanpaã¤, A., Sitarek, J., Snidaric, I., Sobczynska, D., Stamerra, A., Strzys, M., Suriä , T., Takalo, L., Tavecchio, F., Temnikov, P., Terziä , T., Tescaro, D., Teshima, M., Torres, D. F., Toyama, T., Treves, A., Vanzo, G., Vazquez Acosta, M., Vovk, I., Ward, J. E., Will, M., Wu, M. H., and Zanin, R.

Subjects
Individual: SN 2014J [Supernovae], Gamma rays: General, Supernovae: Individual: SN 2014J, Astronomy and Astrophysics, Space and Planetary Science, air, Astrophysics::High Energy Astrophysical Phenomena, Hadron, VHE [gamma ray], FOS: Physical sciences, Astrophysics, Type (model theory), power spectrum, 01 natural sciences, 0103 physical sciences, supernova, MAGIC (telescope), 010303 astronomy & astrophysics, Cherenkov radiation, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Spectral index, 010308 nuclear & particles physics, photon, Gamma ray, imaging, General [Gamma rays], Astronomy and Astrophysic, MAGIC, gamma rays: general, supernovae: individual (SN 2014J), flux, Supernova, Cherenkov counter, ddc:520, high [energy], Electrónica, Física nuclear, Electricidad, Astrophysics - High Energy Astrophysical Phenomena, Energy (signal processing)
Abstract

In this work we present data from observations with the MAGIC telescopes of SN 2014J detected in January 21 2014, the closest Type Ia supernova since Imaging Air Cherenkov Telescopes started to operate. We probe the possibility of very-high-energy (VHE; $E\geq100$ GeV) gamma rays produced in the early stages of Type Ia supernova explosions. We performed follow-up observations after this supernova explosion for 5 days, between January 27 and February 2 in 2014. We search for gamma-ray signal in the energy range between 100 GeV and several TeV from the location of SN 2014J using data from a total of $\sim5.5$ hours of observations. Prospects for observing gamma-rays of hadronic origin from SN 2014J in the near future are also being addressed. No significant excess was detected from the direction of SN 2014J. Upper limits at 95$\%$ confidence level on the integral flux, assuming a power-law spectrum, d$F/$d$E\propto E^{-\Gamma}$, with a spectral index of $\Gamma=2.6$, for energies higher than 300 GeV and 700 GeV, are established at $1.3\times10^{-12}$ and $4.1\times10^{-13}$ photons~cm$^{-2}$s$^{-1}$, respectively. For the first time, upper limits on the VHE emission of a Type Ia supernova are established. The energy fraction isotropically emitted into TeV gamma rays during the first $\sim10$ days after the supernova explosion for energies greater than 300 GeV is limited to $10^{-6}$ of the total available energy budget ($\sim 10^{51}$ erg). Within the assumed theoretical scenario, the MAGIC upper limits on the VHE emission suggest that SN 2014J will not be detectable in the future by any current or planned generation of Imaging Atmospheric Cherenkov Telescopes., Comment: 5 pages, 2 figures. Accepted for publication in A&A

Published
2017

39. Prospects for Cherenkov Telescope Array Observations of the Young Supernova Remnant RX J1713.7−3946

Author

Csaba Balázs, M. Servillat, F. D'Ammando, D. Nosek, T. Yamamoto, A. Bilinsky, H.-S. Zechlin, Francesco Dazzi, A. Fernández-Barral, Satoshi Yoshiike, Catherine Boisson, Philippe Laporte, K. Nishijima, Yutaka Fujita, T. Armstrong, A. Shalchi, S. Kimura, D. Nakajima, Fuyuki Tokanai, Francesco Longo, S. Pavy, Philip Kaaret, W. van Driel, Gianpiero Tagliaferri, L. Nogués, F. Di Pierro, Wystan Benbow, T. Stolarczyk, Marco Padovani, T. Di Girolamo, Johan Bregeon, J. Rico, R. Wischnewski, A. Sillanpää, T. Grabarczyk, E. Pueschel, P. Blasi, S. D. Vergani, A. De Franco, C. Bonavolontà, J. Prast, J. Zorn, Elisabetta Bissaldi, Giuseppe Malaguti, A. Pe'Er, Stefano Covino, Akira Okumura, Takashi Saito, C. Aramo, Hermine Landt, R. Zanin, E. Fedorova, Shinji Hara, Yutaka Ohira, Petr Janecek, Petar Temnikov, T. B. Humensky, E. Fiandrini, C. Townsley, R. J. White, A. Fiasson, Koji Noda, Takanori Yoshikoshi, Y. Ikeno, Elena Amato, Yasuo Fukui, J. P. Lees, M. Nievas-Rosillo, Vito Conforti, Kazunori Kohri, I. Oya, M. Trifoglio, Gavin Rowell, Jacek Niemiec, Juan Abel Barrio, R. Walter, Stefan Wagner, Teresa Mineo, J. J. Watson, Reiko Orito, Masahiro Teshima, Jim Hinton, A. Pisarski, G. Rodriguez Fernandez, F. De Frondat, Robert Wagner, Pedro L. Luque-Escamilla, G. Morlino, Thomas Lohse, B. Rudak, Olaf Reimer, Josep Martí, Subir Sarkar, Martin White, Johann Cohen-Tanugi, Michiyuki Chikawa, Dusan Mandat, T. Montaruli, M. Mohammed, M. Iori, Oscar Blanch, Giovanni Bonanno, Benjamin Koch, M. A. Lopez, Julien Rousselle, M. Heller, Yusuke Konno, G. Maurin, J. Palacio, S. Gunji, C. Di Giulio, M. Zavrtanik, J.-P. Lenain, Adrian Biland, Michael Backes, Miroslav Filipovic, M. I. Martínez, M. Vazquez Acosta, Nicola Giglietto, J. M. Paredes, G. Fontaine, R. Moderski, A.A. Zdziarski, D. Tescaro, V. Vassiliev, C. van Eldik, H. Siejkowski, Stefan Kimeswenger, Shu Koyama, A. Bonardi, R. Gnatyk, S. Vorobiov, Oleh Petruk, M. Del Santo, Michał Szanecki, C. Delgado, Carole Mundell, Tomasz Szepieniec, Michael G. Burton, Bohdan Hnatyk, M. Capalbi, Kunihito Ioka, Jonathan Granot, Bohdan Novosyadlyj, Petr Schovanek, A. Weinstein, M. Stephan, Vikram V. Dwarkadas, L. Valore, Sabrina Einecke, P. Goldoni, J. Jacquemier, Hiroshi Muraishi, Andreas Quirrenbach, Takeshi Nakamori, Stefan Ohm, G. Busetto, Marcos Santander, A. Wierzcholska, Jaime Rosado, M. Yoshida, M. Huetten, S. Eschbach, Tatsuo Yoshida, Tomasz Bulik, Gino Tosti, Valentina Fioretti, Makoto Sawada, D. Zavrtanik, P. A. Caraveo, Mohamed Rameez, Sylvain Chaty, Nu. Komin, D. Dumas, Michael Zacharias, J. M. Huet, Reshmi Mukherjee, F. Lucarelli, L. Di Venere, Shuta J. Tanaka, F. de Palma, Shiu-Hang Lee, A. W. Chen, A. Giuliani, R. L. C. Starling, V. Beshley, Jonathan S. Lapington, Gilles Ferrand, Giovanni Covone, Rodrigo Nemmen, Tsuyoshi Inoue, R. C. Shellard, P. Cumani, G. Lamanna, Stefan Funk, Michele Doro, Koji Mori, G. Pühlhofer, Hidetoshi Sano, Susumu Inoue, Luis Ángel Tejedor, G. Kukec Mezek, Anderson Caproni, L. Freixas Coromina, M. de Naurois, D. Jankowsky, Yoshiyuki Inoue, Elina Lindfors, Saverio Lombardi, D. della Volpe, Giancarlo Cusumano, Andrea Orlati, S. Mangano, Samar Safi-Harb, Alexandre Marcowith, R. López-Coto, Martin Pohl, J. Lefaucheur, Vincenzo Rizi, Masayuki Tanaka, Shigehiro Nagataki, J. L. Rodriguez, Diego Falceta-Gonçalves, J. E. Ward, Petr Travnicek, I. Sadeh, Dominik Elsässer, P. Wilcox, Tsunefumi Mizuno, Kohta Murase, K. Lalik, M. Ostrowski, Vincenzo Testa, Tsuguya Naito, Matteo Cerruti, N. La Palombara, Yukikatsu Terada, Emmanuel Moulin, A. Balzer, M. Palatka, Samo Stanič, D. D'Urso, Łukasz Stawarz, D. Simone, Giuseppe Romeo, Francesco Giordano, Luca Zampieri, Michiko Ohishi, Giuseppe Leto, J.F. Glicenstein, G. De Cesare, Eleonora Torresi, R. A. Cameron, Katsuaki Asano, Ricardo Graciani, Gernot Maier, Paweł Wójcik, R. A. Ong, Jörg R. Hörandel, Carlo Vigorito, S. P. Wakely, Valerio Vagelli, Andrea Bulgarelli, J. Takeda, S. Brau-Nogué, Garret Cotter, Claudio Melioli, Hiroaki Yamamoto, M. Vrastil, Ryo Yamazaki, G. Maneva, N. Maxted, David A. Williams, K. Kosack, Konrad Bernlöhr, Markus Böttcher, Andreas Zech, Jürgen Knödlseder, Daniel Nieto, Paola Grandi, Maria Concetta Maccarone, Y. Inome, I. Telezhinsky, Fabio Acero, Michael C. B. Ashley, D. A. Sanchez, C. de Lisio, Francisco J. Franco, J. L. Dournaux, M. Kraus, G. Bonnoli, Xian Chen, Massimo Persic, Jonathan Blazek, Giacomo Principe, Louis Antonelli, H. Hakobyan, A. De Angelis, Marek Nikolajuk, F. Schüssler, T. Nagayoshi, P.-O. Petrucci, P. Sangiorgi, N. Sakaki, Anthony M. Brown, S. Tsujimoto, J. J. Rodríguez Vázquez, A. Morselli, B. De Lotto, Juan Carlos Helo, S. Nozaki, M. Takahashi, Lili Yang, H. Schoorlemmer, Catherine Braiding, Justin Vandenbroucke, J. A. Graham, P. Vallania, Stanislav Stefanik, M. Fesquet, Roberto Aloisio, Diego F. Torres, Ciro Bigongiari, C. Díaz, Shohei Yanagita, M. Garczarczyk, Abelardo Moralejo, Hideaki Katagiri, R. de los Reyes Lopez, A. Burtovoi, M. Hussein, Hiroyasu Tajima, M. Prouza, M. Renaud, C. Trichard, M. K. Daniel, Maria Chernyakova, Tarek M. Hassan, A. Ziegler, E. M. de Gouveia Dal Pino, Ll. Font, J. Kocot, Jiri Chudoba, J. P. Amans, Enrico Junior Schioppa, Alessandro Costa, Aya Bamba, A. Förster, F. Arqueros, Jan Ebr, M. Hayashida, A. J. Green, Marc Ribó, Olga Sergijenko, Hidetoshi Kubo, A. Porcelli, Tomohiro Inada, J. Biteau, J. Kushida, Jose Luis Contreras, S. Colafrancesco, Nestor Mirabal, V. Bugaev, R. J. García López, Vitalii Sliusar, I. Jung, Kathrin Egberts, G. Fasola, Maxim V. Barkov, Seiji Masuda, P. Romano, Enrico Cascone, V. I. Zhdanov, Elisa Prandini, Helene Sol, Rodolfo Carosi, S. Vercellone, Manuela Vecchi, German Martinez, A. Gadola, S. Griffiths, Satyendra Thoudam, Département d'Astrophysique (ex SAP) (DAP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPP), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), CTA Consortium, High Energy Astrophys. & Astropart. Phys (API, FNWI), Acero F., Aloisio R., Amans J., Amato E., Antonelli L. A., Aramo C., Armstrong T., Arqueros F., Asano K., Ashley M., Backes M., Balazs C., Balzer A., Bamba A., Barkov M., Barrio J. A., Benbow W., Bernlöhr K., Beshley V., Bigongiari C., Biland A., Bilinsky A., Bissaldi E., Biteau J., Blanch O., Blasi P., Blazek J., Boisson C., Bonanno G., Bonardi A., Bonavolontà C., Bonnoli G., Braiding C., Brau-Nogué S., Bregeon J., Brown A. M., Bugaev V., Bulgarelli A., Bulik T., Burton M., Burtovoi A., Busetto G., Böttcher M., Cameron R., Capalbi M., Caproni A., Caraveo P., Carosi R., Cascone E., Cerruti M., Chaty S., Chen A., Chen X., Chernyakova M., Chikawa M., Chudoba J., Cohen-Tanugi J., Colafrancesco S., Conforti V., Contreras J. L., Costa A., Cotter G., Covino S., Covone G., Cumani P., Cusumano G., D’Ammando F., D’Urso D., Daniel M., Dazzi F., De Angelis A., De Cesare G., De Franco A., De Frondat F., de Gouveia Dal Pino E. M., De Lisio C., de los Reyes Lopez R., De Lotto B., de Naurois M., De Palma F., Del Santo M., Delgado C., della Volpe D., Di Girolamo T., Di Giulio C., Di Pierro F., Di Venere L., Doro M., Dournaux J., Dumas D., Dwarkadas V., Díaz C., Ebr J., Egberts K., Einecke S., Elsässer D., Eschbach S., Falceta-Goncalves D., Fasola G., Fedorova E., Fernández-Barral A., Ferrand G., Fesquet M., Fiandrini E., Fiasson A., Filipovíc M. D., Fioretti V., Font L., Fontaine G., Franco F. J., Coromina L. Freixa, Fujita Y., Fukui Y., Funk S., Förster A., Gadola A., López R. Garcia, Garczarczyk M., Giglietto N., Giordano F., Giuliani A., Glicenstein J., Gnatyk R., Goldoni P., Grabarczyk T., Graciani R., Graham J., Grandi P., Granot J., Green A. J., Griffiths S., Gunji S., Hakobyan H., Hara S., Hassan T., Hayashida M., Heller M., Helo J. C., Hinton J., Hnatyk B., Huet J., Huetten M., Humensky T. B., Hussein M., Hörandel J., Ikeno Y., Inada T., Inome Y., Inoue S., Inoue T., Inoue Y., Ioka K., Iori M., Jacquemier J., Janecek P., Jankowsky D., Jung I., Kaaret P., Katagiri H., Kimeswenger S., Kimura S., Knödlseder J., Koch B., Kocot J., Kohri K., Komin N., Konno Y., Kosack K., Koyama S., Kraus M., Kubo H., Mezek G. Kukec, Kushida J., Palombara N. La, Lalik K., Lamanna G., Landt H., Lapington J., Laporte P., Lee S., Lees J., Lefaucheur J., Lenain J.-P., Leto G., Lindfors E., Lohse T., Lombardi S., Longo F., Lopez M., Lucarelli F., Luque-Escamilla P. L., López-Coto R., Maccarone M. C., Maier G., Malaguti G., Mandat D., Maneva G., Mangano S., Marcowith A., Martí J., Martínez M., Martínez G., Masuda S., Maurin G., Maxted N., Melioli C., Mineo T., Mirabal N., Mizuno T., Moderski R., Mohammed M., Montaruli T., Moralejo A., Mori K., Morlino G., Morselli A., Moulin E., Mukherjee R., Mundell C., Muraishi H., Murase K., Nagataki S., Nagayoshi T., Naito T., Nakajima D., Nakamori T., Nemmen R., Niemiec J., Nieto D., Nievas-Rosillo M., Nikołajuk M., Nishijima K., Noda K., Nogues L., Nosek D., Novosyadlyj B., Nozaki S., Ohira Y., Ohishi M., Ohm S., Okumura A., Ong R. A., Orito R., Orlati A., Ostrowski M., Oya I., Padovani M., Palacio J., Palatka M., Paredes J. M., Pavy S., Pe’Er A., Persic M., Petrucci P., Petruk O., Pisarski A., Pohl M., Porcelli A., Prandini E., Prast J., Principe G., Prouza M., Pueschel E., Pühlhofer G., Quirrenbach A., Rameez M., Reimer O., Renaud M., Ribó M., Rico J., Rizi V., Rodriguez J., Fernandez G. Rodriguez, Vázquez J. J. Rodríguez, Romano P., Romeo G., Rosado J., Rousselle J., Rowell G., Rudak B., Sadeh I., Safi-Harb S., Saito T., Sakaki N., Sanchez D., Sangiorgi P., Sano H., Santander M., Sarkar S., Sawada M., Schioppa E. J., Schoorlemmer H., Schovanek P., Schussler F., Sergijenko O., Servillat M., Shalchi A., Shellard R. C., Siejkowski H., Sillanpää A., Simone D., Sliusar V., Sol H., Stanič S., Starling R., Stawarz Ł., Stefanik S., Stephan M., Stolarczyk T., Szanecki M., Szepieniec T., Tagliaferri G., Tajima H., Takahashi M., Takeda J., Tanaka M., Tanaka S., Tejedor L. A., Telezhinsky I., Temnikov P., Terada Y., Tescaro D., Teshima M., Testa V., Thoudam S., Tokanai F., Torres D. F., Torresi E., Tosti G., Townsley C., Travnicek P., Trichard C., Trifoglio M., Tsujimoto S., Vagelli V., Vallania P., Valore L., van Driel W., van Eldik C., Vandenbroucke J., Vassiliev V., Vecchi M., Vercellone S., Vergani S., Vigorito C., Vorobiov S., Vrastil M., Acosta M. L. Vázquez, Wagner S. J., Wagner R., Wakely S. P., Walter R., Ward J. E., Watson J. J., Weinstein A., White M., White R., Wierzcholska A., Wilcox P., Williams D. A., Wischnewski R., Wojcik P., Yamamoto T., Yamamoto H., Yamazaki R., Yanagita S., Yang L., Yoshida T., Yoshida M., Yoshiike S., Yoshikoshi T., Zacharias M., Zampieri L., Zanin R., Zavrtanik M., Zavrtanik D., Zdziarski A., Zech A., Zechlin H., Zhdanov V., Ziegler A., Zorn J., Acero, F., Aloisio, R., Amans, J., Amato, E., Antonelli, L. A., Aramo, C., Armstrong, T., Arqueros, F., Asano, K., Ashley, M., Backes, M., Balazs, C., Balzer, A., Bamba, A., Barkov, M., Barrio, J. A., Benbow, W., Bernlöhr, K., Beshley, V., Bigongiari, C., Biland, A., Bilinsky, A., Bissaldi, E., Biteau, J., Blanch, O., Blasi, P., Blazek, J., Boisson, C., Bonanno, G., Bonardi, A., Bonavolontà, C., Bonnoli, G., Braiding, C., Brau Nogué, S., Bregeon, J., Brown, A. M., Bugaev, V., Bulgarelli, A., Bulik, T., Burton, M., Burtovoi, A., Busetto, G., Böttcher, M., Cameron, R., Capalbi, M., Caproni, A., Caraveo, P., Carosi, R., Cascone, E., Cerruti, M., Chaty, S., Chen, A., Chen, X., Chernyakova, M., Chikawa, M., Chudoba, J., Cohen Tanugi, J., Colafrancesco, S., Conforti, V., Contreras, J. L., Costa, A., Cotter, G., Covino, S., Covone, G., Cumani, P., Cusumano, G., D’Ammando, F., D’Urso, D., Daniel, M., Dazzi, F., De Angelis, A., De Cesare, G., De Franco, A., De Frondat, F., de Gouveia Dal Pino, E. M., De Lisio, C., de los Reyes Lopez, R., De Lotto, B., de Naurois, M., De Palma, F., Del Santo, M., Delgado, C., della Volpe, D., Di Girolamo, T., Di Giulio, C., Di Pierro, F., Di Venere, L., Doro, M., Dournaux, J., Dumas, D., Dwarkadas, V., Díaz, C., Ebr, J., Egberts, K., Einecke, S., Elsässer, D., Eschbach, S., Falceta Goncalves, D., Fasola, G., Fedorova, E., Fernández Barral, A., Ferrand, G., Fesquet, M., Fiandrini, E., Fiasson, A., Filipovíc, M. D., Fioretti, V., Font, L., Fontaine, G., Franco, F. J., Coromina, L. Freixa, Fujita, Y., Fukui, Y., Funk, S., Förster, A., Gadola, A., López, R. Garcia, Garczarczyk, M., Giglietto, N., Giordano, F., Giuliani, A., Glicenstein, J., Gnatyk, R., Goldoni, P., Grabarczyk, T., Graciani, R., Graham, J., Grandi, P., Granot, J., Green, A. J., Griffiths, S., Gunji, S., Hakobyan, H., Hara, S., Hassan, T., Hayashida, M., Heller, M., Helo, J. C., Hinton, J., Hnatyk, B., Huet, J., Huetten, M., Humensky, T. B., Hussein, M., Hörandel, J., Ikeno, Y., Inada, T., Inome, Y., Inoue, S., Inoue, T., Inoue, Y., Ioka, K., Iori, M., Jacquemier, J., Janecek, P., Jankowsky, D., Jung, I., Kaaret, P., Katagiri, H., Kimeswenger, S., Kimura, S., Knödlseder, J., Koch, B., Kocot, J., Kohri, K., Komin, N., Konno, Y., Kosack, K., Koyama, S., Kraus, M., Kubo, H., Mezek, G. Kukec, Kushida, J., Palombara, N. La, Lalik, K., Lamanna, G., Landt, H., Lapington, J., Laporte, P., Lee, S., Lees, J., Lefaucheur, J., Lenain, J. P., Leto, G., Lindfors, E., Lohse, T., Lombardi, S., Longo, Francesco, Lopez, M., Lucarelli, F., Luque Escamilla, P. L., López Coto, R., Maccarone, M. C., Maier, G., Malaguti, G., Mandat, D., Maneva, G., Mangano, S., Marcowith, A., Martí, J., Martínez, M., Martínez, G., Masuda, S., Maurin, G., Maxted, N., Melioli, C., Mineo, T., Mirabal, N., Mizuno, T., Moderski, R., Mohammed, M., Montaruli, T., Moralejo, A., Mori, K., Morlino, G., Morselli, A., Moulin, E., Mukherjee, R., Mundell, C., Muraishi, H., Murase, K., Nagataki, S., Nagayoshi, T., Naito, T., Nakajima, D., Nakamori, T., Nemmen, R., Niemiec, J., Nieto, D., Nievas Rosillo, M., Nikołajuk, M., Nishijima, K., Noda, K., Nogues, L., Nosek, D., Novosyadlyj, B., Nozaki, S., Ohira, Y., Ohishi, M., Ohm, S., Okumura, A., Ong, R. A., Orito, R., Orlati, A., Ostrowski, M., Oya, I., Padovani, M., Palacio, J., Palatka, M., Paredes, J. M., Pavy, S., Pe’Er, A., Persic, M., Petrucci, P., Petruk, O., Pisarski, A., Pohl, M., Porcelli, A., Prandini, E., Prast, J., Principe, G., Prouza, M., Pueschel, E., Pühlhofer, G., Quirrenbach, A., Rameez, M., Reimer, O., Renaud, M., Ribó, M., Rico, J., Rizi, V., Rodriguez, J., Fernandez, G. Rodriguez, Vázquez, J. J. Rodríguez, Romano, P., Romeo, G., Rosado, J., Rousselle, J., Rowell, G., Rudak, B., Sadeh, I., Safi Harb, S., Saito, T., Sakaki, N., Sanchez, D., Sangiorgi, P., Sano, H., Santander, M., Sarkar, S., Sawada, M., Schioppa, E. J., Schoorlemmer, H., Schovanek, P., Schussler, F., Sergijenko, O., Servillat, M., Shalchi, A., Shellard, R. C., Siejkowski, H., Sillanpää, A., Simone, D., Sliusar, V., Sol, H., Stanič, S., Starling, R., Stawarz, Ł., Stefanik, S., Stephan, M., Stolarczyk, T., Szanecki, M., Szepieniec, T., Tagliaferri, G., Tajima, H., Takahashi, M., Takeda, J., Tanaka, M., Tanaka, S., Tejedor, L. A., Telezhinsky, I., Temnikov, P., Terada, Y., Tescaro, D., Teshima, M., Testa, V., Thoudam, S., Tokanai, F., Torres, D. F., Torresi, E., Tosti, G., Townsley, C., Travnicek, P., Trichard, C., Trifoglio, M., Tsujimoto, S., Vagelli, V., Vallania, P., Valore, L., van Driel, W., van Eldik, C., Vandenbroucke, J., Vassiliev, V., Vecchi, M., Vercellone, S., Vergani, S., Vigorito, C., Vorobiov, S., Vrastil, M., Acosta, M. L. Vázquez, Wagner, S. J., Wagner, R., Wakely, S. P., Walter, R., Ward, J. E., Watson, J. J., Weinstein, A., White, M., White, R., Wierzcholska, A., Wilcox, P., Williams, D. A., Wischnewski, R., Wojcik, P., Yamamoto, T., Yamamoto, H., Yamazaki, R., Yanagita, S., Yang, L., Yoshida, T., Yoshida, M., Yoshiike, S., Yoshikoshi, T., Zacharias, M., Zampieri, L., Zanin, R., Zavrtanik, M., Zavrtanik, D., Zdziarski, A., Zech, A., Zechlin, H., Zhdanov, V., Ziegler, A., Zorn, J., Acero et al, F., PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPhP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Acero, F, Aloisio, R, Amans, J, De Lisio, C, Di Girolamo, T, Valore, L, Covone, G, and Al., Et

Subjects
electron, Supernova Remnants, PARTICLE-ACCELERATION, Cherenkov Telescope Array, Astronomy, leptonic, Telescope Array Experiment, pi, Astrophysics, 01 natural sciences, Supernova Remnant, LARGE-AREA TELESCOPE, Spectral line, spectrum, ISM: individual objects, HESS, Supernova remnant, 010303 astronomy & astrophysics, cosmic ray, Physics, cosmic rays gamma rays: ISM ISM: individual objects (RX J1713.7-3946, G347.3-0.5), spatial distribution, Gamma Ray, Cherenkov radiation, MAGNETIC-FIELD, Gamma ray, COSMIC-RAYS, ISM: individual objects (RX J1713.7–3946, G347.3–0.5), Supernova, cosmic rays, gamma rays: ISM, ISM: individual objects (RX J1713.7-3946, G347.3-0.5), Astronomy and Astrophysics, Space and Planetary Science, gamma ray: emission, G347.3–0.5, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, DIFFUSIVE SHOCK ACCELERATION, Electrónica, Física nuclear, Electricidad, individual objects: RX J1713.7–3946 [ISM], Compton scattering, Gamma Rays, G347.3-0.5), NONTHERMAL, accelerator, X-RAYS, Astrophysics::High Energy Astrophysical Phenomena, INSTABILITY, Cosmic ray, hadronic, GLAST, ISM: individual objects (RX J1713.7-3946, ISM [gamma rays], gas, 0103 physical sciences, supernova, ddc:530, X-ray: emission, GAMMA-RAY EMISSION, AMPLIFICATION, BROAD-BAND EMISSION, MOLECULAR CLOUDS, STREAMING, Astrophysics::Galaxy Astrophysics, Astroparticle physics, 010308 nuclear & particles physics, p: relativistic, Institut für Physik und Astronomie, ASTROFÍSICA, gamma ray: VHE, ddc:520, time dependence, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], RAIOS CÓSMICOS
Abstract

著者人数: 382名 (JAXA職員: 井上, 芳幸 : 小山, 志勇 : Lee, Shiu-Hang), Accepted: 2017-04-12, 資料番号: SA1170071000

Published
2017

40. Ex Vivo Organ Repair (Drug and Gene Delivery)

Author

Marcelo Cypel, Shaf Keshavjee, and D. Nakajima

Subjects
Drug, Lung, business.industry, media_common.quotation_subject, medicine.medical_treatment, respiratory system, Gene delivery, Bioinformatics, respiratory tract diseases, Donor lungs, Transplantation, medicine.anatomical_structure, medicine, Lung transplantation, Personalized medicine, business, Ex vivo, media_common
Abstract

Lung transplantation is a life-saving intervention for patients with end-stage lung diseases. However, ultimately, the success of lung transplantation is dependent on the quality and function of the transplanted donor lungs, which are frequently subjected to multiple different injuries. Recent innovations, in particular the development of ex vivo lung perfusion (EVLP) in which donor lungs are preserved under normothermic conditions outside the body, have enabled clinicians to more accurately evaluate the donor lung function prior to transplantation and have significantly impacted donor lung assessment and utilization worldwide. The advancement of EVLP from organ assessment to organ repair will be the next important and challenging step not only to expand the donor lung pool but also to improve graft survival and long-term outcomes after transplantation. The application of enhanced EVLP techniques combined with targeted repairs and molecular therapeutic strategies, including gene and cell-based therapy, will result in improved rehabilitation of injured donor lungs and provide a framework for the application of a personalized medicine approach in lung transplantation.

Published
2017

41. On the measured lifetime of light hypernuclei 3ΛH and 4ΛH

Author

V. Bozkurt, S. Bianchin, Kazuki Yoshida, O. Bertini, D. Nakajima, Y. Ma, M. Kavatsyuk, F. E. Maas, S. Minami, C. Rappold, Eun-Hee Kim, T.R. Saito, and B. Özel-Tashenov

Subjects
Physics, Nuclear physics, Nuclear and High Energy Physics, Lifetime measurement, Posterior probability, Hypernuclei, Bayesian approach, Credible interval, ddc:530, Lambda, Hypertriton, Averaged combination
Abstract

A statistical combination of the experimental lifetime estimations available in the literatures is performed for 3 Λ H and 4 Λ H, including several recent measurements. The combined average values of the lifetime for 3 Λ H and 4 Λ H are respectively 216−16+19 ps and 192−18+20 ps with a reduced χ2 of 0.89 and 0.48. A new insight into the lifetime estimation of the HypHI Phase 0 experiment by a Bayesian approach is also presented. In this approach, several different prior distributions including the combination of previous lifetime data and a Jeffrey prior are used. The principal mode and the smallest credible interval at 68% of the posterior distribution, given by the prior belief of the previous measurements, are 217−16+19 ps and 194−18+20 ps respectively for 3 Λ H and 4 Λ H. The two employed approaches have revealed that the lifetime of hypernuclei 3 Λ H and 4 Λ H can be shorter than the Λ –hyperon lifetime.

Published
2014
Full Text
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42. Hypernuclear spectroscopy of products from Li-6 projectiles on a carbon target at 2 A GeV

Author

Patrick Achenbach, L. Nungesser, T. Hiraiwa, G.J. Tambave, Hiroyuki Tamura, C.J. Yoon, S. Voltz, J. Pochodzalla, T.R. Saito, W. Ott, G. Ickert, Yutaka Mizoi, S. Minami, Tomofumi Nagae, C. Rappold, M. Sekimoto, B. Özel-Tashenov, J. Hoffmann, A. Okamura, Tomokazu Fukuda, S. Bianchin, H. Simon, S. Erturk, M. Sako, T. Takahashi, Atsushi Sakaguchi, B. Göküzüm, S. Ajimura, C. Caesar, S. J. Kim, C. Ayerbe Gayoso, A. Le Fèvre, M. Moritsu, E. Guliev, N. Yokota, M. Kavatsyuk, Z.S. Ketenci, K. Koch, N. Kurz, C.J. Schmidt, Minu Kim, K. Yoshida, V. Bozkurt, O. Bertini, D. Nakajima, T. Aumann, Y. Ma, E. H. Kim, D. Khaneft, H. C. Bhang, F. E. Maas, H. Sugimura, W. Trautmann, KVI - Center for Advanced Radiation Technology, Mizoi, Yutaka -- 0000-0002-4749-0815, Ayerbe Gayoso, Carlos -- 0000-0001-8640-5380, Rappold, Christophe -- 0000-0002-5390-5052, Achenbach, Patrick -- 0000-0002-6754-653X, Caesar, Christoph -- 0000-0001-5844-7073, [Rappold, C.] Univ Giessen, D-35392 Giessen, Germany -- [Rappold, C. -- Kim, E. -- Nakajima, D. -- Saito, T. R. -- Bertini, O. -- Bianchin, S. -- Bozkurt, V. -- Ma, Y. -- Maas, F. -- Minami, S. -- Oezel-Tashenov, B. -- Yoshida, K. -- Aumann, T. -- Gokuzum, B. -- Hoffmann, J. -- Ickert, G. -- Khaneft, D. -- Koch, K. -- Kurz, N. -- Le Fevre, A. -- Ott, W. -- Schmidt, C. J. -- Simon, H. -- Trautmann, W. -- Voltz, S.] GSI Helmholtz Ctr Heavy Ion Res, D-64291 Darmstadt, Germany -- [Kim, E. -- Bhang, H. C. -- Kim, M. -- Kim, S. -- Yoon, C. J.] Seoul Natl Univ, Seoul 151747, South Korea -- [Nakajima, D.] Univ Tokyo, Bunkyo Ku, Tokyo 1130033, Japan -- [Saito, T. R. -- Bertini, O. -- Ma, Y. -- Maas, F. -- Achenbach, P. -- Gayoso, C. Ayerbe -- Khaneft, D. -- Nungesser, L. -- Pochodzalla, J.] Johannes Gutenberg Univ Mainz, D-55099 Mainz, Germany -- [Saito, T. R. -- Maas, F. -- Yoshida, K.] HIM, D-55099 Mainz, Germany -- [Bozkurt, V. -- Erturk, S. -- Gokuzum, B. -- Ketenci, Z. S.] Nigde Univ, TR-51100 Nigde, Turkey -- [Kavatsyuk, M. -- Guliev, E. -- Tambave, G. J.] Univ Groningen, KVI, NL-9747 AA Groningen, Netherlands -- [Yoshida, K. -- Sakaguchi, A.] Osaka Univ, Toyonaka, Osaka 5600043, Japan -- [Ajimura, S.] RCNP, Osaka 5670047, Japan -- [Aumann, T. -- Caesar, C.] Tech Univ Darmstadt, D-64289 Darmstadt, Germany -- [Fukuda, T. -- Mizoi, Y.] Osaka Electrocommun Univ, Neyagawa, Osaka 5728530, Japan -- [Hiraiwa, T. -- Moritsu, M. -- Nagae, T. -- Okamura, A. -- Sako, M. -- Sugimura, H. -- Yokota, N.] Kyoto Univ, Kyoto 6068502, Japan -- [Le Fevre, A.] SUBATECH, F-44307 Nantes 3, France -- [Sekimoto, M. -- Takahashi, T.] KEK, Tsukuba, Ibaraki 3050801, Japan -- [Tamura, H.] Tohoku Univ, Aoba Ku, Sendai, Miyagi 9807875, Japan, and 0-Belirlenecek

Subjects
Nuclear reaction, (Li-6, E=2 GeV/nucleon, Nuclear and High Energy Physics, Maximum likelihood, WEAK DECAY, FOS: Physical sciences, LIFETIME, T-1/2. Compared with other data, deduced Lambda mass, C-12(LAMBDA), H-4), T-1/2, measured Lambda, H-3,H-4 Lambda-hypernuclei invariant mass distribution, T-1/2, measured Lambda, Invariant mass, Nuclear Experiment (nucl-ex), LIGHT HYPERFRAGMENTS, Spectroscopy, Nuclear Experiment, X), Physics, H-4 Lambda-hypernuclei invariant mass distribution, H-3, Projectile, Significance values, lifetime measurement, deduced Lambda mass, H-3,H-4 Lambda-hypernuclei mass, T-1/2. Compared with other data, lifetime measurement, NUCLEAR REACTIONS C(Li-6, Decay time, LAMBDA-HYPERNUCLEI, Atomic physics, t), NUCLEAR REACTIONS C(Li-6, X), (Li-6, t), (Li-6, H-4), E=2 GeV/nucleon, H-4 Lambda-hypernuclei mass, Hypertriton, RELATIVISTIC HYPERNUCLEI
Abstract

WOS: 000322848900009, A novel experiment, aiming at demonstrating the feasibility of hypernuclear spectroscopy with heavy ion beams, was conducted. Using the invariant mass method, the spectroscopy of hypernuclear products of Li-6 projectiles on a carbon target at 2 A GeV was performed. Signals of the Lambda-hyperon and H-3(Lambda) and H-4(Lambda) hypernuclei were observed for final states of p + pi(-), He-3 + pi(-) and He-4 + pi(-), respectively, with significance values of 6.7, 4.7 and 4.9 sigma. By analyzing the proper decay time from secondary vertex distribution with the unbinned maximum likelihood fitting method, their lifetime values were deduced to be 262(-43)(+56) +/- 45 ps for Lambda, 183(-32)(+42) +/- 37 ps for H-3(Lambda), and 140(-33)(+48) +/- 35 ps for H-4(Lambda). (c) 2013 Elsevier B.V. All rights reserved., Electronics Department of the Institute for Nuclear Physics of Mainz University; Helmholtz association as Helmholtz-University Young Investigators Group at GSI [VH-NG-239]; German Research Foundation (DFG) [SA 1696/1-1]; Ministry of Education, Science and Culture of Japan [18042008]; EU FP7 Hadron-Physics-2 SPHERE; GSI Department of Accelerator; GSI Department of Experimental Electronics; GSI Department of the Detector Laboratory; GSI Department of the Target Laboratory, The authors would like to thank the GSI Departments of Accelerator, of Experimental Electronics, of the Detector Laboratory and of the Target Laboratory and the Electronics Department of the Institute for Nuclear Physics of Mainz University for supporting the project. The HypHI project is funded by the Helmholtz association as Helmholtz-University Young Investigators Group VH-NG-239 at GSI, and the German Research Foundation (DFG) under contract number SA 1696/1-1. The authors acknowledge the financial support provided by the Ministry of Education, Science and Culture of Japan, Grant-in-Aid for Scientific Research on Priority Areas 449, and Grant-in-Aid for promotion of Cooperative Research in Osaka Electro-Communication University (2004-2006). This work is also supported by the Ministry of Education, Science and Culture of Japan, Grants-in-Aid for Scientific Research 18042008 and EU FP7 Hadron-Physics-2 SPHERE. A part of this work was carried out on the HIMSTER high performance computing infrastructure provided by the Helmholtz-Institute Mainz.

Published
2013

43. Imaging of surface plasmon polariton propagation on a Au thin film by using tip-enhanced Rayleigh scattering

Author

D. Nakajima, Yoshihiro Ogawa, S. Takahashi, and Fujio Minami

Subjects
Materials science, business.industry, Quantitative Biology::Tissues and Organs, Surface plasmon, Biophysics, Physics::Optics, General Chemistry, Condensed Matter Physics, Interference (wave propagation), Biochemistry, Surface plasmon polariton, Molecular physics, Atomic and Molecular Physics, and Optics, Light scattering, symbols.namesake, Wavelength, Optics, Dispersion relation, symbols, Rayleigh scattering, Thin film, business
Abstract

Surface plasmon polariton (SPP) propagation on a Au thin film has been observed by tip-enhanced Rayleigh scattering. The interference pattern has been observed around the edge of the film. The interference is due to the near-field scattering light at the tip and SPP radiation from the edge of the film. From the interference width, we evaluated the wave number of SPP on the Au film. By changing the wavelength of the incidence light, we have obtained the dispersion relation of the SPP. The experimentally obtained dispersion relation is well corresponding to the calculated one using bulk Au parameters.

Published
2013

44. Lung Lavage and Surfactant Replacement During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced Donor Lung Injury

Author

Ilker Iskender, Manyin Chen, Martin Post, Akihiro Ohsumi, D. Nakajima, Shaf Keshavjee, Marcelo Cypel, Ruud A. W. Veldhuizen, Michael Hsin, Sassan Azad, L. Maahs, R. Kalaf, Tereza Martinu, R. Coutinho, T. Kanou, Thomas K. Waddell, P. Behrens, James F. Lewis, Mingyao Liu, and Brandon Baer

Subjects
Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Pathology, Extracorporeal Circulation, Swine, medicine.medical_treatment, Sus scrofa, 030204 cardiovascular system & hematology, Lung injury, Gastroenterology, Bronchoalveolar Lavage, Statistics, Nonparametric, Gastric Acid, 03 medical and health sciences, chemistry.chemical_compound, Random Allocation, 0302 clinical medicine, Pulmonary surfactant, Internal medicine, Phosphatidylcholine, Preoperative Care, medicine, Lung transplantation, Animals, Transplantation, Analysis of Variance, Lung, business.industry, Interleukin, Pulmonary Surfactants, Lung Injury, Organ Preservation, respiratory system, Tissue Donors, respiratory tract diseases, Respiratory Function Tests, Disease Models, Animal, medicine.anatomical_structure, 030228 respiratory system, chemistry, Reperfusion Injury, Gastric acid, Surgery, Cardiology and Cardiovascular Medicine, business, Lung Transplantation
Abstract

Background Ex vivo lung perfusion (EVLP) provides opportunities to treat injured donor lungs before transplantation. We investigated whether lung lavage, to eliminate inflammatory inhibitory components, followed by exogenous surfactant replacement, could aid lung recovery and improve post-transplant lung function after gastric aspiration injury. Methods Gastric acid aspiration was induced in donor pigs, which were ventilated for 6 hours to develop lung injury. After retrieval and 10 hours of cold preservation, EVLP was performed for 6 hours. The lungs were randomly divided into 4 groups (n = 5, each): (1) no treatment (control), (2) lung lavage, (3) surfactant administration, and (4) lung lavage, followed by surfactant administration. After another 2-hour period of cold preservation, the left lung was transplanted and reperfused for 4 hours. Results Physiologic lung function significantly improved after surfactant administration during EVLP. The EVLP perfusate from the lavage + surfactant group showed significantly lower levels of interleukin (IL)-1β, IL-6, IL-8, and secretory phospholipase A 2 . Total phosphatidylcholine was increased, and minimum surface tension was recovered to normal levels (≤5 mN/m) in the bronchioalveolar fluid after surfactant administration. Lysophosphatidylcholine in bronchioalveolar fluid was significantly lower in the lavage + surfactant group than in the surfactant group. Post-transplant lung function was significantly better in the lavage + surfactant group compared with all other groups. Conclusions Lung lavage, followed by surfactant replacement during EVLP, reduced inflammatory mediators and prevented hydrolysis of phosphatidylcholine, which contributed to the superior post-transplant function in donor lungs with aspiration injury.

Published
2016

45. Performance studies of the new stereoscopic Sum-Trigger-II of MAGIC after one year of operation

Author

D. Nakajima, Francesco Dazzi, D. Herranz Lazaro, Mercedes López, J. Rodriguez Garcia, and T. Schweizer

Subjects
Pixel, Trigger strategy, Computer science, Crab Pulsar, Astrophysics::High Energy Astrophysical Phenomena, Real-time computing, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Stereoscopy, law.invention, Telescope, law, MAGIC (telescope), Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Energy (signal processing), Cherenkov radiation
Abstract

MAGIC is a stereoscopic system of two Imaging Air Cherenkov Telescopes (IACTs) located at La Palma (Canary Islands, Spain) and working in the field of very high energy gamma-ray astronomy. It makes use of a traditional digital trigger with an energy threshold of around 55 GeV. A novel trigger strategy, based on the analogue sum of signals from partially overlapped patches of pixels, leads to a lower threshold. In 2008, this principle was proven by the detection of the Crab Pulsar at 25 GeV by MAGIC in single telescope operation. During Winter 2013/14, a new system, based on this concept, was implemented for stereoscopic observations after several years of development. In this contribution the strategy of the operative stereoscopic trigger system, as well as the first performance studies, are presented. Finally, some possible future improvements to further reduce the energy threshold of this trigger are addressed., 34th International Cosmic Ray Conference 2015

Published
2016

47. Investigating the peculiar emission from the new VHE gamma-ray source H1722+119

Author

M. Hayashida, M. Makariev, B. Biasuzzi, K. Mallot, R. J. García López, Louis Antonelli, D. Dominis Prester, E. Prandini, M. Doert, M. H. Wu, Massimo Persic, F. D'Ammando, Marc Ribó, G. Bonnoli, Abelardo Moralejo, Juri Poutanen, R. Reinthal, V. Fallah Ramazani, P. Bangale, Y. Hanabata, Razmik Mirzoyan, U. Barres de Almeida, Damir Lelas, T. Steinbring, Marina Manganaro, P. G. Prada Moroni, Stefano Covino, Hidetoshi Kubo, P. Antoranz, D. Galindo, J. Becerra González, G. Pedaletti, Dorota Sobczyńska, D. Nakajima, Thomas Bretz, J. Hose, Andrei Berdyugin, Pratik Majumdar, M. V. Fonseca, S. Bonnefoy, A. Sillanpää, Arka Chatterjee, Francesco Longo, D. Elsaesser, F. Di Pierro, K. Kodani, Alexander Hahn, Konstancja Satalecka, Walter Max-Moerbeck, Tomoki Saito, D. Tescaro, Ivica Puljak, Pierre Colin, H. Takami, L. Nogués, U. Menzel, Michele Doro, M. I. Martínez, Gareth Hughes, Talvikki Hovatta, C. Schultz, E. Moretti, Marcel Strzys, D. Fidalgo, Vassil Verguilov, Aaron Dominguez, Diego F. Torres, Julia Thaele, E. de Oña Wilhelmi, Reiko Orito, F. Verrecchia, Sabrina Einecke, Junko Kushida, P. Da Vela, R. López-Coto, J. Rodriguez Garcia, J. E. Ward, M. Palatiello, Elina Lindfors, A. Niedzwiecki, Kyoshi Nishijima, Ievgen Vovk, Wolfgang Rhode, Daniel Mazin, Oscar Blanch, Julian Sitarek, Juan Abel Barrio, L. Maraschi, Francesco Dazzi, David Paneque, A. Fernández-Barral, Markus Garczarczyk, Yusuke Konno, C. Fruck, B. De Lotto, M. Villata, T. Schweizer, T. Toyama, D. Guberman, Tomislav Terzić, K. Frantzen, J. L. Richards, Mosè Mariotti, A.-K. Overkemping, S. Paiano, Saverio Lombardi, Karl Mannheim, D. Hadasch, L. Perri, A. La Barbera, D. Eisenacher Glawion, X. Paredes-Fortuny, P. Temnikov, M. Nievas Rosillo, W. Idec, A. González Muñoz, E. Colombo, B. Banerjee, S. Buson, L. O. Takalo, Masahiro Teshima, Daniela Dorner, R. Zanin, Dariusz Gora, Adrian Biland, M. Gaug, J. Rico, J. Herrera, Koji Noda, Elisa Bernardini, A. De Angelis, A. Treves, Vitaly Neustroev, Jose Luis Contreras, Juan Cortina, G. Maneva, C. M. Raiteri, Nikola Godinovic, Benito Marcote, Max Ludwig Ahnen, Kari Nilsson, P. Giammaria, M. Will, Dario Hrupec, M. A. Lopez, R. Clavero, D. Garrido Terrats, W. Bednarek, Fabrizio Tavecchio, Ll. Font, I. Snidaric, Ana Babić, Stefano Ansoldi, Riccardo Paoletti, J. Palacio, J. M. Paredes, Antonio Stamerra, Alessandro Carosi, Jose Miguel Miranda, F. Borracci, Anthony C. S. Readhead, Universitat de Barcelona, Aalto-yliopisto, Aalto University, Ahnen ML, Ansoldi S, Antonelli LA, Antoranz P, Babic A, Banerjee B, Bangale P, de Almeida UB, Barrio JA, Gonzalez JB, Bednarek W, Bernardini E, Biasuzzi B, Biland A, Blanch O, Bonnefoy S, Bonnoli G, Borracci F, Bretz T, Buson S, Carosi A, Chatterjee A, Clavero R, Colin P, Colombo E, Contreras JL, Cortina J, Covino S, Da Vela P, Dazzi F, De Angelis A, De Lotto B, Wilhelmi ED, Di Pierro F, Doert M, Dominguez A, Prester DD, Dorner D, Doro M, Einecke S, Glawion DE, Elsaesser D, Ramazani VF, Fernandez-Barral A, Fidalgo D, Fonseca MV, Font L, Frantzen K, Fruck C, Galindo D, Lopez RJG, Garczarczyk M, Terrats DG, Gaug M, Giammaria P, Godinovic N, Munoz AG, Gora D, Guberman D, Hadasch D, Hahn A, Hanabata Y, Hayashida M, Herrera J, Hose J, Hrupec D, Hughes G, Idec W, Kodani K, Konno Y, Kubo H, Kushida J, La Barbera A, Lelas D, Lindfors E, Lombardi S, Longo F, Lopez M, Lopez-Coto R, Majumdar P, Makariev M, Mallot K, Maneva G, Manganaro M, Mannheim K, Maraschi L, Marcote B, Mariotti M, Martinez M, Mazin D, Menzel U, Miranda JM, Mirzoyan R, Moralejo A, Moretti E, Nakajima D, Neustroev V, Niedzwiecki A, Rosillo MN, Nilsson K, Nishijima K, Noda K, Nogues L, Orito R, Overkemping A, Paiano S, Palacio J, Palatiello M, Paneque D, Paoletti R, Paredes JM, Paredes-Fortuny X, Pedaletti G, Perri L, Persic M, Poutanen J, Moroni PGP, Prandini E, Puljak I, Rhode W, Ribo M, Rico J, Garcia JR, Saito T, Satalecka K, Schultz C, Schweizer T, Sillanpaa A, Sitarek J, Snidaric I, Sobczynska D, Stamerra A, Steinbring T, Strzys M, Takalo L, Takami H, Tavecchio F, Temnikov P, Terzic T, Tescaro D, Teshima M, Thaele J, Torres DF, Toyama T, Treves A, Verguilov V, Vovk I, Ward JE, Will M, Wu MH, Zanin R, DAmmando F, Berdyugin A, Hovatta T, Max-Moerbeck W, Raiteri CM, Readhead ACS, Reinthal R, Richards JL, Verrecchia F, Villata M, Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Antoranz, P., Babic, A., Banerjee, B., Bangale, P., Barres De Almeida, U., Barrio, J. A., Becerra González, J., Bednarek, W., Bernardini, E., Biasuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Buson, S., Carosi, A., Chatterjee, A., Clavero, R., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., De Oña Wilhelmi, E., Di Pierro, F., Doert, M., Domínguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Eisenacher Glawion, D., Elsaesser, D., Fallah Ramazani, V., Fernández Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C., Galindo, D., García López, R. J., Garczarczyk, M., Garrido Terrats, D., Gaug, M., Giammaria, P., Godinović, N., González Muñoz, A., Gora, D., Guberman, D., Hadasch, D., Hahn, A., Hanabata, Y., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Hughes, G., Idec, W., Kodani, K., Konno, Y., Kubo, H., Kushida, J., La Barbera, A., Lelas, D., Lindfors, E., Lombardi, S., Longo, Francesco, López, M., López Coto, R., Majumdar, P., Makariev, M., Mallot, K., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martínez, M., Mazin, D., Menzel, U., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moretti, E., Nakajima, D., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nilsson, K., Nishijima, K., Noda, K., Nogués, L., Orito, R., Overkemping, A., Paiano, S., Palacio, J., Palatiello, Michele, Paneque, D., Paoletti, R., Paredes, J. M., Paredes Fortuny, X., Pedaletti, G., Perri, L., Persic, M., Poutanen, J., Prada Moroni, P. G., Prandini, E., Puljak, I., Rhode, W., Ribó, M., Rico, J., Rodriguez Garcia, J., Saito, T., Satalecka, K., Schultz, C., Schweizer, T., Sillanpää, A., Sitarek, J., Snidaric, I., Sobczynska, D., Stamerra, A., Steinbring, T., Strzys, M., Takalo, L., Takami, H., Tavecchio, F., Temnikov, P., Terzić, T, Tescaro, D., Teshima, M., Thaele, J., Torres, D. F., Toyama, T., Treves, A., Verguilov, V., Vovk, I., Ward, J. E., Will, M., Wu, M. H., Zanin, R., D'Ammando, F., Berdyugin, A., Hovatta, T., Max Moerbeck, W., Raiteri, C. M., Readhead, A. C. S., Reinthal, R., Richards, J. L., Verrecchia, F., and Villata, M.

Subjects
galaxie [Gamma-rays], gamma-rays: galaxies, UPGRADE, Astrophysics, DETECTED BLAZARS, 01 natural sciences, LARGE-AREA TELESCOPE, law.invention, Raigs gamma, law, galaxies: active, BL Lacertae objects: individual: H1722+119, galaxies, distances and redshifts, BL LACERTAE OBJECTS, ALL-SKY SURVEY, MAGIC, TELESCOPES, LAC OBJECTS, SOURCE CATALOG, MAJOR, HELICAL JETS, CRAB-NEBULA, MAGIC (telescope), 010303 astronomy & astrophysics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), distances and redshift [Galaxies], active BL Lacertae objects, individual, H1722+119 galaxies, distances and redshifts gamma-rays, Galaxies: active, Galaxies: distances and redshifts, Gamma-rays: galaxies, Astronomy and Astrophysics, Space and Planetary Science, galaxies [Gamma-rays], Extragalactic background light, Spectral energy distribution, Electrónica, Física nuclear, Electricidad, Astrophysics - High Energy Astrophysical Phenomena, BL Lac object, active [Galaxies], Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Owens Valley Radio Observatory, Astrophysics::Cosmology and Extragalactic Astrophysics, Telescope, galaxies: active, BL Lacertae objects: individual: H1722+119, galaxies: distances and redshifts, gamma-rays: galaxies, 0103 physical sciences, individual: H1722+119 [BL Lacertae objects], distances and redshifts [Galaxies], ta115, 010308 nuclear & particles physics, Gamma rays, Astronomy, Astronomy and Astrophysic, Redshift, Crab Nebula, 13. Climate action, Galàxies actives, Active galaxies, ddc:520
Abstract

The MAGIC (Major Atmospheric Gamma-ray Imaging Cherenkov) telescopes observed the BL Lac object H1722+119 (redshift unknown) for six consecutive nights between 2013 May 17 and 22, for a total of 12.5 h. The observations were triggered by high activity in the optical band measured by the KVA (Kungliga Vetenskapsakademien) telescope. The source was for the first time detected in the very high energy (VHE, $E > 100$ GeV) $\gamma$-ray band with a statistical significance of 5.9 $\sigma$. The integral flux above 150 GeV is estimated to be $(2.0\pm 0.5)$ per cent of the Crab Nebula flux. We used contemporaneous high energy (HE, 100 MeV $ < E < 100$ GeV) $\gamma$-ray observations from Fermi-LAT (Large Area Telescope) to estimate the redshift of the source. Within the framework of the current extragalactic background light models, we estimate the redshift to be $z = 0.34 \pm 0.15$. Additionally, we used contemporaneous X-ray to radio data collected by the instruments on board the Swift satellite, the KVA, and the OVRO (Owens Valley Radio Observatory) telescope to study multifrequency characteristics of the source. We found no significant temporal variability of the flux in the HE and VHE bands. The flux in the optical and radio wavebands, on the other hand, did vary with different patterns. The spectral energy distribution (SED) of H1722+119 shows surprising behaviour in the $\sim 3\times10^{14} - 10^{18}$ Hz frequency range. It can be modelled using an inhomogeneous helical jet synchrotron self-Compton model., Comment: 12 pages, 5 figures, 2 tables

Published
2016

48. Study of the airborne behavior of cedar pollen and its allergen released from cedar forests in the Kanto plain of Japan

Author

S. Dong, Qingyue Wang, Kazuhiko Sekiguchi, M. Suzuki, S. Lu, D. Nakajima, Makoto Miwa, G. Otsuka, and Y. Takai

Subjects
010504 meteorology & atmospheric sciences, Pollination, 010501 environmental sciences, medicine.disease_cause, 01 natural sciences, Cedar pollen, Altitude, Transportation distance, Habitat, Pollen, medicine, Environmental science, Trajectory analysis, Physical geography, Air mass, 0105 earth and related environmental sciences
Abstract

In recent years, pollinosis has been considered a “national disease” with the big social problems in urban areas of Japan. In this study, the airborne behavior of cedar pollen in the Kanto plain of Japan was observed by a real time pollen automatic measuring instrument during the 2014 pollination season. For calculating cedar pollen source contribution, the backward trajectory analysis was used for calculating 72 hours of trajectories of air mass with the altitude of 500 m from the urban of Saitama city to different areas. It was found that cedar pollen grains transported to Saitama city were mainly derived from the forest of Gunma prefecture located on the north side of Saitama city and the forest of Kanagawa prefecture located on the south side of the city. Transportation of cedar pollen grains depends on the weather conditions, habitat density of cedar trees and transportation distance. The variations in daily pollen counts among different transporting times showed three pollen dispersal peaks observed in the morning, the day time and the night time, while these occurrence rates were different in each month. The peak pollen counts in the day time correlated positively with the daily maximum temperature. The highest pollen counts were observed in the night time within three pollen dispersal peaks. At the same time, the size-segregated allergenic particles were also collected using Andersen high-volume air samplers at the roadside of urban residential zones of Saitama city and on the 10th floor of the research building in Saitama University. Allergenic

Published
2016

50. Observations of Sagittarius A* during the pericenter passage of the G2 object with MAGIC

Author

D. Paneque, D. Garrido Terrats, T. Schweizer, L. Nogués, M. Engelkemeier, M. Makariev, Masahiro Teshima, J. Becerra González, Alessandro Carosi, X. Paredes-Fortuny, F. Di Pierro, A. González Muñoz, A.-K. Overkemping, M. Hayashida, Ruben Lopez-Coto, Elina Lindfors, Laura Maraschi, S. Ansoldi, B. Biasuzzi, Ana Babić, D. Nakajima, J. Rico, M. V. Fonseca, Daniel Mazin, A. Berti, P. Da Vela, Juan Abel Barrio, Jose Miguel Miranda, Arka Chatterjee, Iva Šnidarić, Kyoshi Nishijima, Abelardo Moralejo, A. Treves, Vitaly Neustroev, P. Majumdar, Jose Carlos Herrera, R. J. García López, Benito Marcote, S. Schroeder, T. Steinbring, C. Arcaro, Dariusz Gora, E. Moretti, Pierre Colin, F. Borracci, M. Ribó, Kari Nilsson, K. Frantzen, A. De Angelis, Yusuke Konno, M. Will, Christian Fruck, Stefano Covino, Julian Sitarek, D. Lelas, U. Menzel, I. Puljak, A. Niedzwiecki, Riccardo Paoletti, Julia Thaele, Elisa Prandini, J. Kushida, Dario Hrupec, D. Hadasch, Markus Gaug, D. Galindo, Aaron Dominguez, I. Reichardt, Petar Temnikov, G. Vanzo, R. Zanin, Razmik Mirzoyan, Jose Luis Contreras, Simona Paiano, J. Palacio, M. A. Lopez, Elisa Bernardini, G. Pedaletti, Juan Cortina, A. Biland, Antonio Stamerra, K. Noda, D. Fidalgo, M. Mariotti, J. E. Ward, Juri Poutanen, Dorota Sobczyńska, D. Guberman, Tihomir Surić, Giacomo Bonnoli, J. M. Paredes, S. Bonnefoy, P. Antoranz, G. Maneva, Marina Manganaro, E. de Ona Wilhelmi, M. I. Martínez, W. Idec, P. Bangale, M. Strzys, P. G. Prada Moroni, Diego F. Torres, Konstancja Satalecka, Sabrina Einecke, Michele Doro, A. Sillanpää, K. Kodani, Francesco Longo, V. Fallah Ramazani, Karl Mannheim, Takashi Saito, Max Ludwig Ahnen, Oscar Blanch, M. H. Wu, U. Barres de Almeida, L. Perri, A. La Barbera, Takeshi Toyama, D. Eisenacher Glawion, K. Mallot, M. Nievas Rosillo, J. R. Garcia, Massimo Persic, Leo O. Takalo, Ievgen Vovk, A. Hahn, Hidetoshi Kubo, B. De Lotto, M. Doert, W. Bednarek, V. Verguilov, J. Hose, S. Buson, D. Elsaesser, Markus Garczarczyk, B. Banerjee, Thomas Bretz, S. N. Shore, D. Dominis Prester, S. Lombardi, M. Peresano, Gareth Hughes, Tomislav Terzić, D. Tescaro, N. Godinović, D. Dorner, L. A. Antonelli, R. Clavero, Fabrizio Tavecchio, Eduardo Colombo, Ll. Font, P. Giammaria, M. Palatiello, Francesco Dazzi, A. Fernández-Barral, W. Rhode, Ahnen, M. L., Ansoldi, S., Antonelli, L. A., Antoranz, P., Arcaro, C., Babic, A., Banerjee, B., Bangale, P., Barres De Almeida, U., Barrio, J. A., Becerra González, J., Bednarek, W., Bernardini, E., Berti, Alessio, Biasuzzi, B., Biland, A., Blanch, O., Bonnefoy, S., Bonnoli, G., Borracci, F., Bretz, T., Buson, S., Carosi, A., Chatterjee, A., Clavero, R., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., De Oña Wilhelmi, E., Di Pierro, F., Doert, M., Domã­nguez, A., Dominis Prester, D., Dorner, D., Doro, M., Einecke, S., Eisenacher Glawion, D., Elsaesser, D., Engelkemeier, M., Fallah Ramazani, V., Fernández Barral, A., Fidalgo, D., Fonseca, M. V., Font, L., Frantzen, K., Fruck, C, Galindo, D., García López, R. J., Garczarczyk, M., Garrido Terrats, D., Gaug, M., Giammaria, P., Godinoviä , N., González Muñoz, A., Gora, D., Guberman, D., Hadasch, D., Hahn, A., Hayashida, M., Herrera, J., Hose, J., Hrupec, D., Hughes, G., Idec, W., Kodani, K., Konno, Y., Kubo, H., Kushida, J., La Barbera, A., Lelas, D., Lindfors, E., Lombardi, S., Longo, Francesco, Lã³pez, M., López Coto, R., Majumdar, P., Makariev, M., Mallot, K., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Marcote, B., Mariotti, M., Martã­nez, M., Mazin, D., Menzel, U., Miranda, J. M., Mirzoyan, R., Moralejo, A., Moretti, E., Nakajima, D., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nilsson, K., Nishijima, K., Noda, K., Noguã©s, L., Overkemping, A., Paiano, S., Palacio, J., Palatiello, Michele, Paneque, D., Paoletti, R., Paredes, J. M., Paredes Fortuny, X., Pedaletti, G., Peresano, M., Perri, L., Persic, M., Poutanen, J., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Reichardt, I., Rhode, W., Ribã³, M., Rico, J., Saito, T., Satalecka, K., Schroeder, S., Schweizer, T., Shore, S. N., Sillanpã¤ã¤, A., Sitarek, J., Snidaric, I., Sobczynska, D., Stamerra, A., Steinbring, T., Strzys, M., Suriä , T., Takalo, L., Tavecchio, F., Temnikov, P., Terziä , T., Tescaro, D., Teshima, M., Thaele, J., Torres, D. F., Toyama, T., Treves, A., Vanzo, G., Verguilov, V., Vovk, I., Ward, J. E., Will, M., Wu, M. H., and Zanin, R.

Subjects
Astrophysics::High Energy Astrophysical Phenomena, black hole physics, general [Gamma rays], Galaxy: center, gamma rays: general, FOS: Physical sciences, Context (language use), Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Black hole physic, 0103 physical sciences, MAGIC (telescope), Black hole physics, Gamma rays: general, Astronomy and Astrophysics, Space and Planetary Science, Supernova remnant, 010303 astronomy & astrophysics, Cherenkov radiation, Astrophysics::Galaxy Astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, 010308 nuclear & particles physics, Galactic Center, center [Galaxy], Astronomy and Astrophysic, Galaxy, Black hole, Sagittarius A, ddc:520, Física nuclear, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Astronomy and astrophysics 601, A33 (2017). doi:10.1051/0004-6361/201629355, Context. We present the results of a multi-year monitoring campaign of the Galactic center (GC) with the MAGIC telescopes. These observations were primarily motivated by reports that a putative gas cloud (G2) would be passing in close proximity to the super-massive black hole (SMBH), associated with Sagittarius A*, located at the center of our galaxy. This event was expected to give astronomers a unique chance to study the effect of in-falling matter on the broad-band emission of a SMBH.Aims. We search for potential flaring emission of very-high-energy (VHE; ≥100 GeV) gamma rays from the direction of the SMBH at the GC due to the passage of the G2 object. Using these data we also study the morphology of this complex region.Methods. We observed the GC region with the MAGIC Imaging Atmospheric Cherenkov Telescopes during the period 2012–2015, collecting 67 h of good-quality data. In addition to a search for variability in the flux and spectral shape of the GC gamma-ray source, we use a point-source subtraction technique to remove the known gamma-ray emitters located around the GC in order to reveal the TeV morphology of the extended emission inside that region.Results. No effect of the G2 object on the VHE gamma-ray emission from the GC was detected during the 4 yr observation campaign. We confirm previous measurements of the VHE spectrum of Sagittarius A*, and do not detect any significant variability of the emission from the source. Furthermore, the known VHE gamma-ray emitter at the location of the supernova remnant G0.9+0.1 was detected, as well as the recently discovered VHE source close to the GG radio arc.Key words: Galaxy: center / gamma rays: general / black hole physics, Published by EDP Sciences, Les Ulis

Published
2016

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