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3. Selecting Informative Variables in the Identification Problem

Author

Eugene D. Mihov and Oleg V. Nepomnyashchiy

Subjects
Parameter identification problem, business.industry, General Mathematics, General Physics and Astronomy, Pattern recognition, Artificial intelligence, Machine learning, computer.software_genre, business, computer, Mathematics
Published
2016
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4. Mathematical Modeling of H-processes

Author

Oleg V. Nepomnyashchikh, A. V. Medvedev, and Eugene D. Mihov

Subjects
priori information, urogenital system, Computer science, General Mathematics, Dimension (graph theory), Nonparametric statistics, Structure (category theory), непараметрические алгоритмы, General Physics and Astronomy, идентификация, непараметрическая модель, H-модели, H-model, Space (mathematics), Quantitative Biology::Cell Behavior, Quantitative Biology::Subcellular Processes, Algebra, Identification (information), пространство дробной размерности, априорная информация, nonparametric algorithms, identification, fractional dimension space, Nonparametric model, nonparametric model
Abstract

The problem of the discrete continuous processes having "tubular" structure in space "input-output" variables’s modeling is investigated. The fact that when the trained parametrical models of "tubular" processes’s creating, it’s important to use corresponding nonparametric indicators, is reflected. Some private examples of "tubular" processes’s modeling are reviewed. This examples proves that "tubular" processes proceed in the space of fractional dimension Исследуется проблема моделирования дискретно-непрерывных процессов, имеющих «трубчатую» структуру в пространстве «входных–выходных» переменных. Отражено то, что при постро- ении обучающихся параметрических моделей «трубчатых» процессов необходимо использование соответствующих непараметрических индикаторов. Рассмотрены некоторые частные примеры моделирования «трубчатых» процессов, из которых следует, что «трубчатые» процессы протекают в пространстве дробной размерности

Published
2016
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5. Saturday, 17 July 2010

Author

I. Dimova, R. Hlushchuk, A. Makanya, V. Djonov, M. Theurl, W. Schgoer, K. Albrecht, A. Beer, J. R. Patsch, P. Schratzberger, S. Mahata, R. Kirchmair, M. Didie, P. Christalla, T. Rau, T. Eschenhagen, U. Schumacher, Q. Lin, M. Zenke, W. Zimmmermann, M. Hoch, P. Fischer, B. Stapel, E. Missol-Kolka, S. Erschow, M. Scherr, H. Drexler, D. Hilfiker-Kleiner, I. Diebold, A. Petry, P. Kennel, T. Djordjevic, J. Hess, A. Goerlach, J. Castellano, R. Aledo, J. Sendra, P. Costales, L. Badimon, V. Llorente-Cortes, E. Dworatzek, S. Mahmoodzadeh, V. Regitz-Zagrosek, A. Posa, C. Varga, A. Berko, M. Veszelka, P. Szablics, B. Vari, I. Pavo, F. Laszlo, M. Brandenburger, J. Wenzel, R. Bogdan, D. Richardt, M. Reppel, J. Hescheler, H. Terlau, A. Dendorfer, J. Heijman, Y. Rudy, R. Westra, P. Volders, R. Rasmusson, V. Bondarenko, M. D. Ertas Gokhan, M. D. Ural Ertan, P. H. D. Karaoz Erdal, P. H. D. Aksoy Ayca, M. D. Kilic Teoman, M. D. Kozdag Guliz, M. D. Vural Ahmet, M. D. Ural Dilek, C. Poulet, T. Christ, E. Wettwer, U. Ravens, C. Van Der Pouw Kraan, S. Schirmer, J. Fledderus, P. Moerland, T. Leyen, J. Piek, N. Van Royen, A. Horrevoets, F. Fleissner, V. Jazbutyte, J. Fiedler, P. Galuppo, M. Mayr, G. Ertl, J. Bauersachs, T. Thum, S. Protze, A. Bussek, F. Li, R. Hoo, K. Lam, A. Xu, P. Subramanian, E. Karshovska, R. Megens, S. Akhtar, K. Heyll, Y. Jansen, C. Weber, A. Schober, M. Zafeiriou, C. Noack, A. Renger, R. Dietz, L. Zelarayan, M. Bergmann, I. Meln, A. Malashicheva, S. Anisimov, N. Kalinina, V. Sysoeva, A. Zaritskey, A. Barbuti, A. Scavone, N. Mazzocchi, A. Crespi, D. Capilupo, D. Difrancesco, L. Qian, W. Shim, Y. Gu, S. Mohammed, P. Wong, M. Zafiriou, H. Schaeffer, P. Kovacs, J. Simon, A. Varro, P. Athias, J. Wolf, O. Bouchot, D. Vandroux, A. Mathe, A. De Carvalho, G. Laurent, P. Rainer, M. Huber, F. Edelmann, T. Stojakovic, A. Trantina-Yates, M. Trauner, B. Pieske, D. Von Lewinski, A. De Jong, A. Maass, S. Oberdorf-Maass, I. Van Gelder, Y. Lin, J. Li, F. Wang, Y. He, X. Li, H. Xu, X. Yang, R. Coppini, C. Ferrantini, C. Ferrara, A. Rossi, A. Mugelli, C. Poggesi, E. Cerbai, N. Rozmaritsa, N. Voigt, D. Dobrev, M.-C. Kienitz, G. Zoidl, K. Bender, L. Pott, Z. Kohajda, A. Kristof, L. Virag, N. Jost, A. Trafford, B. Prnjavorac, E. Mujaric, J. Jukic, K. Abduzaimovic, K. Brack, V. Patel, J. Coote, G. Ng, R. Wilders, A. Van Ginneken, A. Verkerk, P. Xaplanteris, C. Vlachopoulos, K. Baou, C. Vassiliadou, I. Dima, N. Ioakeimidis, C. Stefanadis, W. Ruifrok, C. Qian, H. Sillje, H. Van Goor, D. Van Veldhuisen, W. Van Gilst, R. De Boer, K. Schmidt, F. Kaiser, J. Erdmann, C. De Wit, O. Barnett, Y. Kyyak, F. Cesana, L. Boffi, T. Mauri, M. Alloni, M. Betelli, S. Nava, C. Giannattasio, G. Mancia, R. Vilskersts, J. Kuka, B. Svalbe, E. Liepinsh, M. Dambrova, A. Zakrzewicz, J. Maroski, B. Vorderwuelbecke, K. Fiedorowicz, L. Da Silva-Azevedo, A. Pries, B. Gryglewska, M. Necki, M. Zelawski, T. Grodzicki, E. Scoditti, M. Massaro, M. Carluccio, A. Distante, C. Storelli, R. De Caterina, O. Kocgirli, S. Valcaccia, V. Dao, T. Suvorava, S. Kumpf, M. Floeren, M. Oppermann, G. Kojda, C. Leo, J. Ziogas, J. Favaloro, O. Woodman, W. Goettsch, A. Marton, C. Goettsch, H. Morawietz, E. Khalifa, Z. Ashour, V. Rupprecht, F. Scalera, J. Martens-Lobenhoffer, S. Bode-Boeger, W. Li, Y. Kwan, G. Leung, F. Patella, A. Mercatanti, L. Pitto, G. Rainaldi, I. Tsimafeyeu, Y. Tishova, N. Wynn, S. Kalinchenko, M. Clemente Lorenzo, M. Grande, F. Barriocanal, M. Aparicio, A. Martin, J. Hernandez, J. Lopez Novoa, C. Martin Luengo, A. Kurlianskaya, T. Denisevich, N. Barth, A. Loot, I. Fleming, Y. Wang, A. Gabrielsen, R. Ripa, E. Jorgensen, J. Kastrup, G. Arderiu, E. Pena, K. Kobus, J. Czyszek, A. Kozlowska-Wiechowska, P. Milkiewicz, M. Milkiewicz, R. Madonna, E. Montebello, Y. Geng, J. Chin-Dusting, D. Michell, M. Skilton, J. Dixon, A. Dart, X. Moore, M. Ehrbar, P. Reichmuth, N. Heinimann, B. Hewing, V. Stangl, K. Stangl, M. Laule, G. Baumann, A. Ludwig, R. Widmer-Teske, A. Mueller, P. Stieger, H. Tillmanns, R. Braun-Dullaeus, D. Sedding, K. Troidl, L. Eller, I. Benli, H. Apfelbeck, W. Schierling, C. Troidl, W. Schaper, T. Schmitz-Rixen, R. Hinkel, T. Trenkwalder, A. Pfosser, F. Globisch, G. Stachel, C. Lebherz, I. Bock-Marquette, C. Kupatt, C. Seyler, E. Duthil-Straub, E. Zitron, E. Scholz, D. Thomas, J. Gierten, C. Karle, R. Fink, T. Padro, R. Lugano, M. Garcia-Arguinzonis, M. Schuchardt, J. Pruefer, M. Toelle, N. Pruefer, V. Jankowski, J. Jankowski, W. Zidek, M. Van Der Giet, P. Fransen, C. Van Hove, C. Michiels, J. Van Langen, H. Bult, R. Quarck, M. Wynants, E. Alfaro-Moreno, M. Rosario Sepulveda, F. Wuytack, D. Van Raemdonck, B. Meyns, M. Delcroix, F. Christofi, S. Wijetunge, P. Sever, A. Hughes, J. Ohanian, S. Forman, V. Ohanian, C. Gibbons, S. Vernia, A. Das, V. Shah, M. Casado, W. Bielenberg, J. Daniel, J.-M. Daniel, K. Hersemeyer, T. Schmidt-Woell, D. Kaetzel, H. Tillmans, S. Kanse, E. Tuncay, H. Kandilci, E. Zeydanli, N. Sozmen, D. Akman, S. Yildirim, B. Turan, N. Nagy, K. Acsai, A. Farkas, J. Papp, A. Toth, C. Viero, S. Mason, A. Williams, S. Marston, D. Stuckey, E. Dyer, W. Song, M. El Kadri, G. Hart, M. Hussain, A. Faltinova, J. Gaburjakova, L. Urbanikova, M. Hajduk, B. Tomaskova, M. Antalik, A. Zahradnikova, P. Steinwascher, K. Jaquet, A. Muegge, G. Wang, M. Zhang, C. Tesi, H. Ter Keurs, S. Kettlewell, G. Smith, A. Workman, I. Lenaerts, P. Holemans, S. Sokolow, S. Schurmans, A. Herchuelz, K. Sipido, G. Antoons, X. Wehrens, N. Li, J. R. Respress, A. De Almeida, R. Van Oort, H. Lohmann, M. Saes, A. Messer, O. Copeland, M. Leung, F. Matthes, J. Steinbrecher, G. Salinas-Riester, L. Opitz, G. Hasenfuss, S. Lehnart, G. Caracciolo, M. Eleid, S. Carerj, K. Chandrasekaran, B. Khandheria, P. Sengupta, I. Riaz, L. Tyng, Y. Dou, A. Seymour, C. Dyer, S. Griffin, S. Haswell, J. Greenman, S. Yasushige, P. Amorim, T. Nguyen, M. Schwarzer, F. Mohr, T. Doenst, S. Popin Sanja, D. Lalosevic, I. Capo, T. Momcilov Popin, A. Astvatsatryan, M. Senan, G. Shafieian, N. Goncalves, I. Falcao-Pires, T. Henriques-Coelho, D. Moreira-Goncalves, A. Leite-Moreira, L. Bronze Carvalho, J. Azevedo, M. Andrade, I. Arroja, M. Relvas, G. Morais, M. Seabra, A. Aleixo, J. Winter, M. Zabunova, I. Mintale, D. Lurina, I. Narbute, I. Zakke, A. Erglis, Z. Marcinkevics, S. Kusnere, A. Abolins, J. Aivars, U. Rubins, Y. Nassar, D. Monsef, G. Hamed, S. Abdelshafy, L. Chen, Y. Wu, J. Wang, C. Cheng, M. Sternak, T. Khomich, A. Jakubowski, M. Szafarz, W. Szczepanski, L. Mateuszuk, J. Szymura-Oleksiak, S. Chlopicki, J. Sulicka, M. Strach, I. Kierzkowska, A. Surdacki, T. Mikolajczyk, W. Balwierz, T. Guzik, V. Dmitriev, E. Oschepkova, O. Polovitkina, V. Titov, A. Rogoza, R. Shakur, S. Metcalfe, J. Bradley, S. Demyanets, C. Kaun, S. Kastl, S. Pfaffenberger, I. Huk, G. Maurer, K. Huber, J. Wojta, O. Eriksson, M. Aberg, A. Siegbahn, G. Niccoli, G. Sgueglia, M. Conte, S. Giubilato, N. Cosentino, G. Ferrante, F. Crea, D. Ilisei, M. Leon, F. Mitu, E. Kyriakakis, M. Philippova, M. Cavallari, V. Bochkov, B. Biedermann, G. De Libero, P. Erne, T. Resink, C. Bakogiannis, C. Antoniades, D. Tousoulis, M. Demosthenous, C. Psarros, N. Sfyras, K. Channon, S. Del Turco, T. Navarra, G. Basta, V. Carnicelli, S. Frascarelli, R. Zucchi, A. Kostareva, G. Sjoberg, A. Gudkova, E. Semernin, E. Shlyakhto, T. Sejersen, N. Cucu, M. Anton, D. Stambuli, A. Botezatu, C. Arsene, E. Lupeanu, G. Anton, J. Patsch, E. Huber, C. Lande, A. Cecchettini, L. Tedeschi, M. Trivella, L. Citti, B. Chen, Y. Ma, Y. Yang, X. Ma, F. Liu, M. Hasanzad, L. Rejali, M. Fathi, A. Minassian, R. Mohammad Hassani, A. Najafi, M. Sarzaeem, S. Sezavar, A. Akhmedov, R. Klingenberg, K. Yonekawa, C. Lohmann, S. Gay, W. Maier, M. Neithard, T. Luescher, X. Xie, Z. Fu, A. Kevorkov, L. Verduci, F. Cremisi, A. Wonnerth, K. Katsaros, G. Zorn, T. Weiss, R. De Rosa, G. Galasso, F. Piscione, G. Santulli, G. Iaccarino, R. Piccolo, R. Luciano, M. Chiariello, M. Szymanski, R. Schoemaker, H. Hillege, S. Rizzo, C. Basso, G. Thiene, M. Valente, S. Rickelt, W. Franke, G. Bartoloni, S. Bianca, E. Giurato, C. Barone, G. Ettore, I. Bianca, P. Eftekhari, G. Wallukat, A. Bekel, F. Heinrich, M. Fu, M. Briedert, J. Briand, J. Roegel, K. Pilichou, S. Korkmaz, T. Radovits, S. Pali, K. Hirschberg, S. Zoellner, S. Loganathan, M. Karck, G. Szabo, A. Pucci, J. Pantaleo, S. Martino, G. Pelosi, M. Matteucci, C. Kusmic, N. Vesentini, F. Piccolomini, F. Viglione, A. L'abbate, J. Slavikova, M. Chottova Dvorakova, W. Kummer, A. Campanile, L. Spinelli, M. Ciccarelli, S. De Gennaro, E. Assante Di Panzillo, B. Trimarco, R. Akbarzadeh Najar, S. Ghaderian, A. Tabatabaei Panah, H. Vakili, A. Rezaei Farimani, G. Rezaie, A. Beigi Harchegani, N. Hamdani, C. Gavina, J. Van Der Velden, H. Niessen, G. Stienen, W. Paulus, C. Moura, I. Lamego, C. Eloy, J. Areias, T. Bonda, M. Dziemidowicz, T. Hirnle, I. Dmitruk, K. Kaminski, W. Musial, M. Winnicka, A. Villar, D. Merino, M. Ares, F. Pilar, E. Valdizan, M. Hurle, J. Nistal, V. Vera, P. Karuppasamy, S. Chaubey, T. Dew, R. Sherwood, J. Desai, L. John, M. Marber, G. Kunst, E. Cipolletta, A. Attanasio, C. Del Giudice, P. Campiglia, M. Illario, A. Berezin, E. Koretskaya, E. Bishop, I. Fearon, J. Heger, B. Warga, Y. Abdallah, B. Meyering, K. Schlueter, H. Piper, G. Euler, A. Lavorgna, S. Cecchetti, T. Rio, G. Coluzzi, C. Carrozza, E. Conti, F. Andreotti, A. Glavatskiy, O. Uz, E. Kardesoglu, O. Yiginer, S. Bas, O. Ipcioglu, N. Ozmen, M. Aparci, B. Cingozbay, F. Ivanes, M. Hillaert, S. Susen, F. Mouquet, P. Doevendans, B. Jude, G. Montalescot, E. Van Belle, C. Castellani, A. Angelini, O. De Boer, C. Van Der Loos, G. Gerosa, A. Van Der Wal, I. Dumitriu, P. Baruah, J. Kaski, O. Maytham, J. D Smith, M. Rose, A. Cappelletti, A. Pessina, M. Mazzavillani, G. Calori, A. Margonato, S. Cassese, C. D'anna, A. Leo, A. Silenzi, M. Baca', L. Biasucci, D. Baller, U. Gleichmann, J. Holzinger, T. Bitter, D. Horstkotte, A. Antonopoulos, A. Miliou, C. Triantafyllou, W. Masson, D. Siniawski, P. Sorroche, L. Casanas, W. Scordo, J. Krauss, A. Cagide, T. Huang, A. Wiedon, S. Lee, K. Walker, K. O'dea, P. Perez Berbel, V. Arrarte Esteban, M. Garcia Valentin, M. Sola Villalpando, C. Lopez Vaquero, L. Caballero, M. Quintanilla Tello, F. Sogorb Garri, G. Duerr, N. Elhafi, T. Bostani, L. Swieny, E. Kolobara, A. Welz, W. Roell, O. Dewald, N. Kaludercic, E. Takimoto, T. Nagayama, K. Chen, J. Shih, D. Kass, F. Di Lisa, N. Paolocci, L. Vinet, M. Pezet, F. Briec, M. Previlon, P. Rouet-Benzineb, A. Hivonnait, F. Charpentier, J. Mercadier, M. Cobo, M. Llano, C. Montalvo, V. Exposito, L. Meems, B. Westenbrink, L. Biesmans, V. Bito, R. Driessen, C. Huysmans, I. Mourouzis, C. Pantos, G. Galanopoulos, M. Gavra, P. Perimenis, D. Spanou, D. Cokkinos, T. Panasenko, S. Partsch, C. Harjung, A. Bogdanova, D. Mihov, P. Mocharla, S. Yakushev, J. Vogel, M. Gassmann, R. Tavakoli, D. Johansen, E. Sanden, C. Xi, R. Sundset, K. Ytrehus, M. Bliksoen, A. Rutkovskiy, L. Mariero, I. Vaage, K. Stenslokken, O. Pisarenko, V. Shulzhenko, I. Studneva, L. Serebryakova, O. Tskitishvili, Y. Pelogeykina, A. Timoshin, A. Vanin, L. Ziberna, M. Lunder, G. Drevensek, S. Passamonti, L. Gorza, B. Ravara, C. Scapin, M. Vitadello, F. Zigrino, J. Gwathmey, F. Del Monte, G. Vilahur, O. Juan-Babot, B. Onate, L. Casani, S. Lemoine, G. Calmettes, B. Jaspard-Vinassa, C. Duplaa, T. Couffinhal, P. Diolez, P. Dos Santos, A. Fusco, D. Sorriento, P. Cervero, A. Feliciello, E. Barnucz, K. Kozichova, M. Hlavackova, J. Neckar, F. Kolar, O. Novakova, F. Novak, C. Barsanti, N. Abraham, D. Muntean, S. Mirica, O. Duicu, A. Raducan, M. Hancu, O. Fira-Mladinescu, V. Ordodi, J. Voelkl, B. Haubner, G. Neely, C. Moriell, S. Seidl, O. Pachinger, J. Penninger, and B. Metzler

Subjects
Physiology, Physiology (medical), Cardiology and Cardiovascular Medicine
Published
2010
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6. A strategic development model for the role of the biomedical physicist in the education of healthcare professionals in Europe

Author

Michael Wucherer, Carmel J. Caruana, Jan H. Meijer, Eliseo Vano, M.R. Malisan, Violeta Karenauskaite, Marta Wasilewska-Radwanska, Eugeniusz Rokita, D. Mihov, Philip P. Dendy, Andre H. Aurengo, Matti Weckström, Vojtech Mornstein, Soren Mattson, Physics and medical technology, and ICaR - Heartfailure and pulmonary arterial hypertension

Subjects
Engineering, Models, Educational, academic role development, Knowledge management, Biomedical Research, 020205 medical informatics, Health Personnel, Physics education, Biophysics, General Physics and Astronomy, Context (language use), strategic planning, 02 engineering and technology, Audit, Gap analysis, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Health care, 0202 electrical engineering, electronic engineering, information engineering, Radiology, Nuclear Medicine and imaging, biomedical physics education, SWOT analysis, Strategic planning, business.industry, Physics, General Medicine, Benchmarking, SWOT audit, Europe, Engineering ethics, medical education, business
Abstract

This is the third of a series of articles targeted at biomedical physicists providing educational services to other healthcare professions, whether in a university faculty of medicine/health sciences or otherwise (e.g., faculty of science, hospital-based medical physics department). The first paper identified the past and present role of the biomedical physicist in the education of the healthcare professions and highlighted issues of concern. The second paper reported the results of a comprehensive SWOT (strengths, weaknesses, opportunities, threats) audit of that role. In this paper we present a strategy for the development of the role based on the outcomes of the SWOT audit. The research methods adopted focus on the importance of strategic planning at all levels in the provision of educational services. The analytical process used in the study was a pragmatic blend of the various theoretical frameworks described in the literature on strategic planning research as adapted for use in academic role development. Important results included identification of the core competences of the biomedical physicist in this context; specification of benchmarking schemes based on experiences of other biomedical disciplines; formulation of detailed mission and vision statements; gap analysis for the role. The paper concludes with a set of strategies and specific actions for gap reduction.

Published
2010
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7. A comprehensive SWOT audit of the role of the biomedical physicist in the education of healthcare professionals in Europe

Author

Andre H. Aurengo, M.R. Malisan, Eliseo Vano, Michael Wucherer, Marta Wasilewska-Radwanska, Carmel J. Caruana, Eugeniusz Rokita, Philip P. Dendy, D. Mihov, Matti Weckström, Vojtech Mornstein, Violeta Karenauskaite, Jan H. Meijer, Biophysics Photosynthesis/Energy, LaserLaB - Energy, Physics and medical technology, and Other Research

Subjects
Models, Educational, Engineering, Knowledge management, Higher education, Health Personnel, Biophysics, General Physics and Astronomy, Audit, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, SDG 17 - Partnerships for the Goals, Health care, Curriculum development, Humans, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, SWOT analysis, Curriculum, Strategic planning, business.industry, General Medicine, Public relations, Europe, business, Health Physics, Strengths and weaknesses
Abstract

Although biomedical physicists provide educational services to the healthcare professions in the majority of universities in Europe, their precise role with respect to the education of the healthcare professions has not been studied systematically. To address this issue we are conducting a research project to produce a strategic development model for the role using the well-established SWOT (Strengths, Weaknesses, Opportunities, Threats) methodology. SWOT based strategic planning is a two-step process: one first carries out a SWOT position audit and then uses the identified SWOT themes to construct the strategic development model. This paper reports the results of a SWOT audit for the role of the biomedical physicist in the education of the healthcare professions in Europe. Internal Strengths and Weaknesses of the role were identified through a qualitative survey of biomedical physics departments and biomedical physics curricula delivered to healthcare professionals across Europe. External environmental Opportunities and Threats were identified through a systematic survey of the healthcare, healthcare professional education and higher education literature and categorized under standard PEST (Political, Economic, Social-Psychological, Technological-Scientific) categories. The paper includes an appendix of terminology. Defined terms are marked with an asterisk in the text. © 2009 Associazione Italiana di Fisica Medica.

Published
2010
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8. Study on the Phase equilibrium in the Systems Sodium Selenate — Cadmium Selenate — Water and Sodium Selenate — Manganese Selenate — Water at 25 °C

Author

D. Mihov and T. Oykova

Subjects
chemistry.chemical_classification, Cadmium, Chemistry, Phase equilibrium, Inorganic chemistry, chemistry.chemical_element, General Chemistry, Manganese, Condensed Matter Physics, Selenate, law.invention, Sodium selenate, chemistry.chemical_compound, law, General Materials Science, Crystallization, Solubility, Inorganic compound, Nuclear chemistry
Abstract

The phase equilibrium in the systems Na2SeO4CdSeO4H2O and Na2SeO4MnSeO4H2O were studied and it was established that new phases were obtained — double salts with a composition: Na2Cd(SeO4)2 · 2 H2O and Na2Mn(SeO4)2 · 2 H2O. The fields of phase equilibrium of the double salts in the triple systems were determined. The composition of the new phases and the number of the water molecules of crystallization were investigated, respectively by the Schreinemackers' method of physico-chemical analysis and thermogravimetrical analysis. An X-ray diffraction analysis of the new phases obtained was done. Untersucht wurden die Phasengleichgewichte in den Systemen Na2SeO4CdSeO4H2O und Na2SeO4MnSeO4H2O. Dabei wurde festgestellt, das in beiden Phasen neue Phasen entstehen, namlich Doppelsalze der Zusammensetzung Na2Cd(SeO4)2 · 2 H2O und Na2Mn(SeO4)2 · 2 H2O. Die Felder der im Gleichgewicht existierenden Doppelsalze in den Dreistoffystemen wurden bestimmt. Die Zusammensetzung der neuen Phasen wird auf physikalisch-chemischem Wege nach der Methode von Schreinemackers, die Anzahl der Kristallwassermolekule auch durch derivatographische Analyse bestimmt. Die entstandenen neuen Phasen wurden mittels Rontgenphasenanalyse untersucht.

Published
1992
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9. Phase Interaction in the Systems Sodium Selenate – Copper Selenate – Water and Sodium Selenate – Zinc Selenate – Water at 25 °C

Author

D. Mihov, P. Pavlova, and T. Oykova

Subjects
chemistry.chemical_classification, Inorganic chemistry, chemistry.chemical_element, General Chemistry, Zinc, Condensed Matter Physics, Selenate, Copper, law.invention, Sodium selenate, chemistry.chemical_compound, chemistry, law, X-ray crystallography, General Materials Science, Solubility, Crystallization, Inorganic compound, Nuclear chemistry
Abstract

The phase equilibrium in the systems Na2SeO4–CuSeO4–H2O and Na2SeO4–ZnSeO4–H2O were studied and it was established that new phases were obtained – double salts with a composition: Na2Cu(SeO4)2 · 2 H2O and Na2Zn(SeO4)2 · 2 H2O. The fields of phase equilibrium of the double salts in the triple systems were determined. The composition of the new phases was investigated by the Schreinemackers' method of physico-chemical analysis, and the number of the water molecules of crystallization – by thermogravimetrical analysis. An X-ray diffraction analysis of the new phases obtained was done. Untersucht werden die Phasengleichgewichte in den Systemen Na2SeO4 – CuSeO4 – H2O und Na2SeO4–ZnSeO4–H2O. Dabei wird festgestellt, das in beiden Phasen neue Phasen entstehen, namlich Doppelsalze der Zusammensetzung Na2Cu(SeO4)2 · 2H2O und Na2Zn(SeO4)2 · 2H2O. Die Felder der im Gleichgewicht existierenden Doppelsalze in den Dreistoffsystemen werden bestimmt. Die Zusammensetzung der neuen Phasen wird auf physikalisch-chemischem Wege nach der Methode von Schreinemackers, die Anzahl der Kristallwassermolekule auch durch derivatographische Analyse bestimmt. Die entstandenen neuen Phasen werden mittels Rontgenphasenanalyse untersucht.

Published
1991
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10. SU-FF-T-516: Parameter Invariant TCP Radiation Therapy Plan Ranking

Author

D Mihov, K Markov, N Stavreva, and P Stavrev

Subjects
medicine.medical_treatment, General Medicine, Invariant (physics), Poisson distribution, Tumor site, Standard deviation, Combinatorics, Normal distribution, Radiation therapy, symbols.namesake, Histogram, Statistics, medicine, symbols, Dosimetry, Mathematics
Abstract

Purpose: To demonstrate via numerical simulations that the following statement cannot be rejected: If for a given value of the radiosensitivity a, the following inequality TCP(SF2,{vi,di}1) > TCP(SF2,{vi,di}2) is valid, then it is valid for any other value of a, where TCP=exp(‐ r S vi SF2 di/2). The parameterization in terms of SF2 = e‐2a was chosen because SF2 is defined in the closed interval [0,1]. The dose‐volume histograms (DVH) ‐ {vi,di}1 and {vi,di}2 ‐ correspond to two rival radiation treatment (RT) plans, for a given tumor site. Method and Materials: It has been indicated in previous works that even though the exact parameter values of TCP and NTCP models might not be known with an apodictive certainty, the TCP/NTCP values may be used as a measure for RT plan ranking (1,2). We investigate only TCP based plan ranking here. It has been shown that gross tumor differential DVHs could be well represented by the Normal distribution with a certain mean and standard deviation (3,4). We generated 105 pairs of pseudo GTV DVHs, with a mean in the dose interval [40,70] Gy and a standard deviation ‐ [1,4] Gy. For each pair of DVHs representing a pair of rival RT plans the corresponding TCP values as a function of SF2 were calculated and compared. Results: No cases contradicting the above statement were observed. Conclusion: The knowledge of the exact values of the Poisson TCP model parameters is irrelevant for the purpose of RT plan ranking on the basis of comparing the outcome produced by the plans in terms of TCP

Published
2009
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11. Geomagnetic Fluctuations and Self-Poisoning Attempted Suicides

Author

V. Milev and D. Mihov

Subjects
Geomagnetic storm, Geography, Earth's magnetic field, Human organism, Climatology, Self poisoning
Abstract

In our opinion, changes in the geomagnetic field induced by solar activity undoubtedly have a definite effect on the human organism. Previous investigations have not found any correlation between geomagnetic fluctuations and the number of suicidal attempts. A. D. Pokorny and R. B. Mefferd1 studied 2497 suicides in Texas, committed during the period 1959–1961. Geomagnetic activity was characterized by means of 3-hour Kp-indexes. No correlation between suicides and geomagnetic fluctuations was established. R. Danneel2 explored 3033 suicides in the province of Northern Rhein attempted during the period of January — December 1971. Geomagnetic activity was measured with S9-index. Again, no correlation between geomagnetic activity and suicides was found.

Published
1984
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12. Selecting Informative Variables in the Identification Problem

Author

Eugene D. Mihov, Oleg V. Nepomnyashchiy, Eugene D. Mihov, and Oleg V. Nepomnyashchiy

Abstract

The problem of multidimensional object classification with small training sample is considered. The following algorithms of estimating variable informativeness are considered: Ad, Del, AdDel. A new algorithm for selecting informative variables is proposed. It is based on the optimization of the coefficient vector of the kernel fuzziness. Some modification of this algorithm is also discussed. The comparative analysis of existing methods for selecting informative variables is presented.

13. Activity of two hyaluronan preparations on primary human oral fibroblasts.

Author

Asparuhova MB, Kiryak D, Eliezer M, Mihov D, and Sculean A

Subjects
Cell Movement drug effects, Cell Proliferation drug effects, Cells, Cultured, Collagen Type III genetics, Collagen Type III metabolism, Drug Compounding, Fibroblasts metabolism, Gene Expression drug effects, Gene Expression genetics, Gingiva cytology, Humans, Matrix Metalloproteinase 2 genetics, Matrix Metalloproteinase 2 metabolism, Matrix Metalloproteinase 3 genetics, Matrix Metalloproteinase 3 metabolism, Palate cytology, Regenerative Endodontics, Transforming Growth Factor beta3 genetics, Transforming Growth Factor beta3 metabolism, Wound Healing genetics, Connective Tissue physiology, Fibroblasts drug effects, Fibroblasts physiology, Hyaluronic Acid administration & dosage, Hyaluronic Acid pharmacology, Regeneration drug effects, Wound Healing drug effects
Abstract

Background and Objective: The potential benefit of using hyaluronan (HA) in reconstructive periodontal surgery is still a matter of debate. The aim of the present study was to evaluate the effects of two HA formulations on human oral fibroblasts involved in soft tissue wound healing/regeneration., Material and Methods: Metabolic, proliferative and migratory abilities of primary human palatal and gingival fibroblasts were examined upon HA treatment. To uncover the mechanisms whereby HA influences cellular behavior, wound healing-related gene expression and activation of signaling kinases were analyzed by qRT-PCR and immunoblotting, respectively., Results: The investigated HA formulations maintained the viability of oral fibroblasts and increased their proliferative and migratory abilities. They enhanced expression of genes encoding type III collagen and transforming growth factor-β3, characteristic of scarless wound healing. The HAs upregulated the expression of genes encoding pro-proliferative, pro-migratory, and pro-inflammatory factors, with only a moderate effect on the latter in gingival fibroblasts. In palatal but not gingival fibroblasts, an indirect effect of HA on the expression of matrix metalloproteinases 2 and 3 was detected, potentially exerted through induction of pro-inflammatory cytokines. Finally, our data pointed on Akt, Erk1/2 and p38 as the signaling molecules whereby the HAs exert their effects on oral fibroblasts., Conclusion: Both investigated HA formulations are biocompatible and enhance the proliferative, migratory and wound healing properties of cell types involved in soft tissue wound healing following regenerative periodontal surgery. Our data further suggest that in gingival tissues, the HAs are not likely to impair the healing process by prolonging inflammation or causing excessive MMP expression at the repair site., (© 2018 The Authors. Journal of Periodontal Research Published by John Wiley & Sons Ltd.)

Published
2019
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14. Glycosaminoglycans: Sorting determinants in intracellular protein traffic.

Author

Mihov D and Spiess M

Subjects
Animals, Cell Nucleus metabolism, Endocytosis, Endoplasmic Reticulum metabolism, Endosomes metabolism, Epithelial Cells ultrastructure, Glycosaminoglycans chemistry, Golgi Apparatus metabolism, Humans, Protein Transport, Proteoglycans chemistry, Secretory Vesicles metabolism, Epithelial Cells metabolism, Glycosaminoglycans metabolism, Protein Processing, Post-Translational, Proteoglycans metabolism
Abstract

Intracellular transport of proteins to their appropriate destinations is crucial for the maintenance of cellular integrity and function. Sorting information is contained either directly in the amino acid sequence or in a protein's post-translational modifications. Glycosaminoglycans (GAGs) are characteristic modifications of proteoglycans. GAGs are long unbranched polysaccharide chains with unique structural and functional properties also contributing to protein sorting in various ways. By deletion or insertion of GAG attachment sites it has been shown that GAGs affect polarized sorting in epithelial cells, targeting to and storage in secretory granules, and endocytosis. Most recently, the role of GAGs as signals for rapid trans-Golgi-to-cell surface transport, dominant over the cytosolic sorting motifs in the core protein, was demonstrated. Here, we provide an overview on existing data on the roles of GAGs on protein and proteoglycan trafficking., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Published
2015
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15. Chondroitin Sulfate Accelerates Trans-Golgi-to-Surface Transport of Proteoglycan Amyloid Precursor Protein.

Author

Mihov D, Raja E, and Spiess M

Subjects
Endosomes metabolism, HeLa Cells, Humans, Protein Transport, Amyloid beta-Protein Precursor metabolism, Cell Membrane metabolism, Chondroitin Sulfate Proteoglycans metabolism, Chondroitin Sulfates metabolism, Protein Processing, Post-Translational, trans-Golgi Network metabolism
Abstract

The amyloid precursor protein (APP) is a membrane protein implicated in the pathogenesis of Alzheimer's disease. APP is a part-time proteoglycan, as splice variants lacking exon 15 are modified by a chondroitin sulfate glycosaminoglycan (GAG) chain. Investigating the effect of the GAG chain on the trafficking of APP in non-polarized cells, we found it to increase the steady-state surface-to-intracellular distribution, to reduce the rate of endocytosis and to accelerate transport kinetics from the trans-Golgi network (TGN) to the plasma membrane. Deletion of the cytosolic domain resulted in delayed surface arrival of GAG-free APP, but did not affect the rapid export kinetics of the proteoglycan form. Protein-free GAG chains showed the same TGN-to-cell surface transport kinetics as proteoglycan APP. Endosome ablation experiments were performed to distinguish between indirect endosomal and direct pathways to the cell surface. Surprisingly, TGN-to-cell surface transport of both GAG-free and proteoglycan APP was found to be indirect via transferrin-positive endosomes. Our results show that GAGs act as alternative sorting determinants in cellular APP transport that are dominant over cytoplasmic signals and involve distinct sorting mechanisms., (© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2015
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16. Erythropoietin activates nitric oxide synthase in murine erythrocytes.

Author

Mihov D, Vogel J, Gassmann M, and Bogdanova A

Subjects
Animals, Enzyme Activation, Enzyme Inhibitors metabolism, Erythropoietin genetics, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Nitrates metabolism, Nitric Oxide metabolism, Nitric Oxide Synthase Type III genetics, Nitrites metabolism, Oxidation-Reduction, Phosphatidylinositol 3-Kinases metabolism, Protein Binding, Proto-Oncogene Proteins c-akt metabolism, Superoxides metabolism, Erythrocytes enzymology, Erythropoietin metabolism, Nitric Oxide Synthase Type III metabolism
Abstract

Erythropoietin (Epo) is the main regulator of erythrocyte production and a potent cytoprotective factor. It was suggested that some of Epo cytoprotective properties are due to its regulation of nitric oxide (NO) production. Recently, functionally active endothelial type NO synthase (eNOS) was discovered in mature murine and human red blood cells (RBC-eNOS). The goal of the present study was to characterize the effect of physiological and therapeutic doses of Epo on RBC-eNOS function. We found that recombinant human Epo (rHuEpo) binds specifically to mouse erythrocytes. Epo binding sites are not equally distributed through the RBC population but prevail in reticulocytes and young erythrocytes with about 105 receptors/cell, compared with adult and old erythrocytes containing 1-4 receptors/cell. The treatment of mouse erythrocytes with rHuEpo resulted in a time- and dose-dependent upregulation of NO production mediated via activation of the phosphatidylinositol-3-kinase /Akt pathway and RBC-eNOS phosphorylation at Ser-1177. Finally, when erythrocytes were incubated in L-arginine-free medium, rHuEpo treatment resulted in upregulation of superoxide radical production with concomitant shifting of the cellular redox state toward more oxidized state. Epo-induced changes in erythrocyte redox potential were absent in erythrocytes from eNOS-deficient mice.

Published
2009
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17. Erythropoietin protects from reperfusion-induced myocardial injury by enhancing coronary endothelial nitric oxide production.

Author

Mihov D, Bogdanov N, Grenacher B, Gassmann M, Zünd G, Bogdanova A, and Tavakoli R

Subjects
Animals, Apoptosis drug effects, Atrial Natriuretic Factor blood, Body Water metabolism, Cardiotonic Agents pharmacology, Coronary Vessels metabolism, Disease Models, Animal, Drug Evaluation, Preclinical methods, Endothelium, Vascular metabolism, Erythropoietin pharmacology, Heart Transplantation pathology, Male, Myocardial Reperfusion Injury metabolism, Myocardial Reperfusion Injury pathology, Oxidative Stress, Rats, Rats, Inbred Lew, Recombinant Proteins, Systemic Inflammatory Response Syndrome blood, Systemic Inflammatory Response Syndrome prevention & control, Troponin T blood, Cardiotonic Agents therapeutic use, Coronary Vessels drug effects, Endothelium, Vascular drug effects, Erythropoietin therapeutic use, Myocardial Reperfusion Injury prevention & control, Nitric Oxide biosynthesis
Abstract

Objective: Cardioprotective properties of recombinant human Erythropoietin (rhEpo) have been shown in in vivo regional or ex vivo global models of ischemia-reperfusion (I/R) injury. The aim of this study was to characterize the cardioprotective potential of rhEPO in an in vivo experimental model of global I/R approximating the clinical cardiac surgical setting and to gain insights into the myocardial binding sites of rhEpo and the mechanism involved in its cardioprotective effect., Methods: Hearts of donor Lewis rats were arrested with cold crystalloid cardioplegia and after 45 min of cold global ischemia grafted heterotopically into the abdomen of recipient Lewis rats. Recipients were randomly assigned to control non-treated or Epo-treated group receiving 5000 U/kg of rhEpo intravenously 20 min prior to reperfusion. At 5 time points 5-1440 min after reperfusion, the recipients (n=6-8 at each point) were sacrificed, blood and native and grafted hearts harvested for subsequent analysis., Results: Treatment with rhEpo resulted in a significant reduction in myocardial I/R injury (plasma troponin T) in correlation with preservation of the myocardial redox state (reduced glutathione). The extent of apoptosis (activity of caspase 3 and caspase 9, TUNEL test) in our model was very modest and not significantly affected by rhEpo. Immunostaining of the heart tissue with anti-Epo antibodies showed an exclusive binding of rhEpo to the coronary endothelium with no binding of rhEpo to cardiomyocytes. Administration of rhEpo resulted in a significant increase in nitric oxide (NO) production assessed by plasma nitrite levels. Immunostaining of heart tissue with anti-phospho-eNOS antibodies showed that after binding to the coronary endothelium, rhEpo increased the phosphorylation and thus activation of endothelial nitric oxide synthase (eNOS) in coronary vessels. There was no activation of eNOS in cardiomyocytes., Conclusions: Intravenous administration of rhEpo protects the heart against cold global I/R. Apoptosis does not seem to play a major role in the process of tissue injury in this model. After binding to the coronary endothelium, rhEpo enhances NO production by phosphorylation and thus activation of eNOS in coronary vessels. Our results suggest that cardioprotective properties of rhEpo are at least partially mediated by NO released by the coronary endothelium.

Published
2009
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18. Enhanced erythro-phagocytosis in polycythemic mice overexpressing erythropoietin.

Author

Bogdanova A, Mihov D, Lutz H, Saam B, Gassmann M, and Vogel J

Subjects
Animals, Disease Models, Animal, Erythrocytes cytology, Erythrocytes pathology, Erythropoietin physiology, Flow Cytometry, Gene Expression Regulation, Humans, Macrophages physiology, Mice, Mice, Transgenic, Potassium blood, Reticulocytes cytology, Reticulocytes pathology, Erythrocytes physiology, Erythropoietin genetics, Phagocytosis physiology, Polycythemia Vera genetics
Abstract

Adaptive mechanisms to hematocrit levels of 0.9 in our erythropoietin-overexpressing mice (tg6) include increased plasma nitric oxide levels and erythrocyte flexibility. Doubled reticulocyte counts in tg6 suggest an increased erythrocyte turnover. Here we show that compared with wild-type (wt) animals, erythrocyte lifespan in tg6 is 70% lower in tg6 mice. Transgenic mice have a younger erythrocyte population as indicated by higher intercellular water and potassium content, higher flexibility, decreased density, increased surface to volume ratio, and decreased osmotic fragility. Interestingly, despite being younger, the tg6 erythrocyte population also harbors characteristics of accelerated aging such as an increased band 4.1a to 4.1b ratio, signs of oxidative stress, or decreased surface CD47 and sialic acids. In tg6, in vivo tracking of PKH26-labeled erythrocytes revealed dramatically increased erythrocyte incorporation by their liver macrophages. In vitro experiments showed that tg6 macrophages are more active than wt macrophages and that tg6 erythrocytes are more attractive for macrophages than wt ones. In conclusion, in tg6 mice erythrocyte aging is accelerated, which results, together with an increased number and activity of their macrophages, in enhanced erythrocyte clearance. Our data points toward a new mechanism down-regulating red cell mass in excessive erythrocytosis in mice.

Published
2007
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