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1. 2.8 INVASIVE STUDY FOR TESTING NON-INVASIVE METHODS OF AORTIC PRESSURE ESTIMATION

Author

Andrea Guala, F. Tosello, D. Leone, L. Sabia, F. D’Ascenzo, T. Crea, C. Moretti, F. Gaita, F. Veglio, L. Ridolfi, and A. Milan

Subjects
Specialties of internal medicine, RC581-951, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Purpose: Aortic blood pressure has a superior prognostic value with respect to the brachial pressure [ 1]. Nonetheless, the low efficacy of the most used non-invasive methods (i.e., approaches based on the generalized transfer function (GTF)) may hamper the detection of this superiority in population studies [2]. In this sense, low-order, patient-specific whole-body mathematical models might help to bridge brachial to aortic pressure waveforms. We aimed to compare (i) GTF, (ii) a patient-specific 1D-0D mathematical model, and (iii) brachial blood pressure in the estimation of invasive aortic pressure measured through catheter. Method: One-hundred patients referred to diagnostic coronary angiography were included in this study. Brachial pressure was measured with a validated automatic oscillometric device simultaneously to invasive aortic pressure, which was measured with a calibrated fluid-filled catheter. End-systolic and end-diastolic left ventricular volumes, carotid-femoral pulse wave velocity and tonometric radial waveform were measured immediately prior to the invasive procedure and were used to set GTF and the mathematical model. Results: Oscillometric brachial pressure overestimated both systolic (2.4 ± 12.6 mmHg, R2 = 0.71) and diastolic (3.7 ± 9.8 mmHg, R2 = 0.48) aortic pressure. GTF method underestimated systolic (9.4 ± 11 mmHg, R2 = 0.71) and overestimated diastolic (4.5 ± 10.2 mmHg, R2 = 0.4) aortic pressure. Mathematical model underestimated both systolic (4 ± 16.5 mmHg, R2 = 0.47) and diastolic (3.9 ± 10.4 mmHg, R2 = 0.62) aortic pressure. Brachial pressure and GTF methods presented trends toward systolic and diastolic pressure overestimation for higher aortic pressure, while mathematical modeling not. Conclusions: Systolic and diastolic oscillometric brachial pressures give a better predictor of aortic pressure extremes with respect to both GTF- and mathematical model-based methods.

Published
2017
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3. Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

Author

Sadiya Parveen, Jessica Shen, Shichun Lun, Liang Zhao, Jesse Alt, Benjamin Koleske, Robert D. Leone, Rana Rais, Jonathan D. Powell, John R. Murphy, Barbara S. Slusher, and William R. Bishai

Subjects
Science
Abstract

Abstract As one of the most successful human pathogens, Mycobacterium tuberculosis (Mtb) has evolved a diverse array of determinants to subvert host immunity and alter host metabolic patterns. However, the mechanisms of pathogen interference with host metabolism remain poorly understood. Here we show that a glutamine metabolism antagonist, JHU083, inhibits Mtb proliferation in vitro and in vivo. JHU083-treated mice exhibit weight gain, improved survival, a 2.5 log lower lung bacillary burden at 35 days post-infection, and reduced lung pathology. JHU083 treatment also initiates earlier T-cell recruitment, increased proinflammatory myeloid cell infiltration, and a reduced frequency of immunosuppressive myeloid cells when compared to uninfected and rifampin-treated controls. Metabolomic analysis of lungs from JHU083-treated Mtb-infected mice reveals citrulline accumulation, suggesting elevated nitric oxide (NO) synthesis, and lowered levels of quinolinic acid which is derived from the immunosuppressive metabolite kynurenine. JHU083-treated macrophages also produce more NO potentiating their antibacterial activity. When tested in an immunocompromised mouse model of Mtb infection, JHU083 loses its therapeutic efficacy suggesting the drug’s host-directed effects are likely to be predominant. Collectively, these data reveal that JHU083-mediated glutamine metabolism inhibition results in dual antibacterial and host-directed activity against tuberculosis.

Published
2023
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5. Serine synthesis pathway upregulated by E-cadherin is essential for the proliferation and metastasis of breast cancers

Author

Geonhui Lee, Claudia Wong, Anna Cho, Junior J. West, Ashleigh J. Crawford, Gabriella C. Russo, Bishwa Ranjan Si, Jungwoo Kim, Lauren Hoffner, Cholsoon Jang, Moonjung Jung, Robert D. Leone, Konstantinos Konstantopoulos, Andrew J. Ewald, Denis Wirtz, and Sangmoo Jeong

Subjects
Article
Abstract

The loss of E-cadherin (E-cad), an epithelial cell adhesion molecule, has been implicated in the epithelial-mesenchymal transition (EMT), promoting invasion and migration of cancer cells and, consequently, metastasis. However, recent studies have demonstrated that E-cad supports the survival and proliferation of metastatic cancer cells, suggesting that our understanding of E-cad in metastasis is far from comprehensive. Here, we report that E-cad upregulates thede novoserine synthesis pathway (SSP) in breast cancer cells. The SSP provides metabolic precursors for biosynthesis and resistance to oxidative stress, critically beneficial for E-cad-positive breast cancer cells to achieve faster tumor growth and more metastases. Inhibition of PHGDH, a rate- limiting enzyme in the SSP, significantly and specifically hampered the proliferation of E-cad- positive breast cancer cells and rendered them vulnerable to oxidative stress, inhibiting their metastatic potential. Our findings reveal that E-cad adhesion molecule significantly reprograms cellular metabolism, promoting tumor growth and metastasis of breast cancers.

Published
2023

8. Data from Interrogation of T Cell–enriched Tumors Reveals Prognostic and Immunotherapeutic Implications of Polyamine Metabolism

Author

Jonathan D. Powell, Elana Fertig, Drew Pardoll, Carole Fakhry, Tanguy Seiwert, Robert A. Casero, Mark Burns, Raj Mandal, Rossin Erbe, Tracy Murray-Stewart, Robert D. Leone, Michael Considine, Rajeev Pandey, and R. Alex Harbison

Abstract

Metabolic features of the tumor microenvironment (TME) antagonize antitumor immunity. We hypothesized that T cell–infiltrated (Thi) tumors with a known antigen should exhibit superior clinical outcomes, though some fare worse given unfavorable metabolic features leveraging T cell–infiltrated (Thi), human papillomavirus–related (HPV+) head and neck squamous cell carcinomas (HNSC) to test this hypothesis. Expression of 2,520 metabolic genes was analyzed among Thi HPV+ HNSCs stratified by high-risk molecular subtype. RNA sequencing (RNA-seq) data from The Cancer Genome Atlas (TCGA; 10 cancer types), single-cell RNA-seq data, and an immunotherapy-treated melanoma cohort were used to test the association between metabolic gene expression and clinical outcomes and contribution of tumor versus stromal cells to metabolic gene expression. Polyamine (PA) metabolism genes were overexpressed in high-risk, Thi HPV+ HNSCs. Genes involved in PA biosynthesis and transport were associated with T-cell infiltration, recurrent or persistent cancer, overall survival status, primary site, molecular subtype, and MYC genomic alterations. PA biogenesis gene sets were associated with tumor-intrinsic features while myeloid cells in HPV+ HNSCs were enriched in PA catabolism, regulatory, transport, putrescine, and spermidine gene set expression. PA gene set expression also correlated with IFNγ or cytotoxic T-cell single-sample gene set enrichment analysis (ssGSEA) scores across TCGA tumor types. PA transport ssGSEA scores were associated with poor survival whereas putrescine ssGSEA scores portended better survival for several tumor types. Thi melanomas enriched in PA synthesis or combined gene set expression exhibited worse anti-PD-1 responses. These data address hurdles to antitumor immunity warranting further investigation of divergent PA metabolism in the TME.Significance:Despite the presence of tumor-infiltrating lymphocytes and antigen, antitumor immunity is often insufficient in tumor control. We leverage HPV-related head and neck cancers to identify metabolic challenges to antitumor immune responses. PA metabolism is associated with tumor-intrinsic features while the myeloid compartment exhibits enriched PA regulatory gene expression.

Published
2023

9. Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities againstMycobacterium tuberculosis

Author

Sadiya Parveen, Jessica Shen, Shichun Lun, Liang Zhao, Benjamin Koleske, Robert D. Leone, Rana Rais, Jonathan D. Powell, John R. Murphy, Barbara S. Slusher, and William R. Bishai

Subjects
Article
Abstract

As one of the most successful human pathogens,Mycobacterium tuberculosis(Mtb) has evolved a diverse array of determinants to subvert host immunity and alter host metabolic patterns. However, the mechanisms of pathogen interference with host metabolism remain poorly understood. Here we show that a novel glutamine metabolism antagonist, JHU083, inhibitsMtbproliferation in vitro and in vivo. JHU083-treated mice exhibit weight gain, improved survival, a 2.5 log lower lung bacillary burden at 35 days post-infection, and reduced lung pathology. JHU083 treatment also initiates earlier T-cell recruitment, increased proinflammatory myeloid cell infiltration, and a reduced frequency of immunosuppressive myeloid cells when compared to uninfected and rifampin-treated controls. Metabolomics analysis of lungs from JHU083-treatedMtb-infected mice revealed reduced glutamine levels, citrulline accumulation suggesting elevated NOS activity, and lowered levels of quinolinic acid which is derived from the immunosuppressive metabolite kynurenine. When tested in an immunocompromised mouse model ofMtbinfection, JHU083 lost its therapeutic efficacy suggesting the drug’s host-directed effects are likely to be predominant. Collectively, these data reveal that JHU083-mediated glutamine metabolism inhibition results in dual antibacterial and host-directed activity against tuberculosis.

Published
2023

10. Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug

Author

Rana Rais, Kathryn M. Lemberg, Lukáš Tenora, Matthew L. Arwood, Arindom Pal, Jesse Alt, Ying Wu, Jenny Lam, Joanna Marie H. Aguilar, Liang Zhao, Diane E. Peters, Carolyn Tallon, Rajeev Pandey, Ajit G. Thomas, Ranjeet P. Dash, Tanguy Seiwert, Pavel Majer, Robert D. Leone, Jonathan D. Powell, and Barbara S. Slusher

Subjects
Multidisciplinary, Glutamine, Neoplasms, Diazooxonorleucine, Humans, Prodrugs, CD8-Positive T-Lymphocytes, Enzyme Inhibitors
Abstract

6-Diazo-5-oxo- l -norleucine (DON) is a glutamine antagonist that suppresses cancer cell metabolism but concurrently enhances the metabolic fitness of tumor CD8 + T cells. DON showed promising efficacy in clinical trials; however, its development was halted by dose-limiting gastrointestinal (GI) toxicities. Given its clinical potential, we designed DON peptide prodrugs and found DRP-104 [isopropyl( S )-2-(( S )-2-acetamido-3-(1 H -indol-3-yl)-propanamido)-6-diazo-5-oxo-hexanoate] that was preferentially bioactivated to DON in tumor while bioinactivated to an inert metabolite in GI tissues. In drug distribution studies, DRP-104 delivered a prodigious 11-fold greater exposure of DON to tumor versus GI tissues. DRP-104 affected multiple metabolic pathways in tumor, including decreased glutamine flux into the TCA cycle. In efficacy studies, both DRP-104 and DON caused complete tumor regression; however, DRP-104 had a markedly improved tolerability profile. DRP-104’s effect was CD8 + T cell dependent and resulted in robust immunologic memory. DRP-104 represents a first-in-class prodrug with differential metabolism in target versus toxicity tissue. DRP-104 is now in clinical trials under the FDA Fast Track designation.

Published
2022

12. Experimental investigation on the fatigue and fracture properties of a fine pearlitic rail steel

Author

D. Leonetti and B. Schotsman

Subjects
r350ht rail steel, fatigue crack growth, rotating bending, fracture toughness, Mechanical engineering and machinery, TJ1-1570, Structural engineering (General), TA630-695
Abstract

This study reports an experimental investigation of the fatigue and fracture resistance of R350HT, a heat-treated pearlitic rail steel with refined microstructure used in rails. Monotonic tensile, rotating bending, linear elastic plane strain fracture toughness, and fatigue crack growth rate tests are presented. The results are used to outline the basic properties and are corroborated by fractographic investigation. This enables the identification of the dominant type of fracture. Regarding fatigue and fracture resistance, the investigated material shows similar properties as other pearlitic rail steels, such as R260. At room temperature, the dominating fracture is of brittle cleavage type, showing some ductile regions associated with pro-eutectoid.

Published
2024
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13. Strong slope‐aspect control of regolith thickness by bedrock foliation

Author

R. P. Callahan, Clifford S. Riebe, Bradley J. Carr, Jon Chorover, Jordan D. Leone, W. Steven Holbrook, and Ty P. A. Ferré

Subjects
geography, geography.geographical_feature_category, Bedrock, Geography, Planning and Development, Earth and Planetary Sciences (miscellaneous), Critical zone, Saprolite, Petrology, Regolith, Foliation, Geology, Earth-Surface Processes
Published
2020

14. Next steps for clinical translation of adenosine pathway inhibition in cancer immunotherapy

Author

Ryan C. Augustin, Robert D. Leone, Aung Naing, Lawrence Fong, Riyue Bao, and Jason J. Luke

Subjects
Pharmacology, Cancer Research, Adenosine, Oncology, Neoplasms, Immunology, Molecular Medicine, Immunology and Allergy, Humans, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunotherapy, RC254-282
Abstract

Increasing evidence supports targeting the adenosine pathway in immuno-oncology with several clinical programs directed at adenosine A2 receptor (A2AR, A2BR), CD73 and CD39 in development. Through a cyclic-AMP-mediated intracellular cascade, adenosine shifts the cytokine and cellular profile of the tumor microenvironment away from cytotoxic T cell inflammation toward one of immune tolerance. A perpetuating cycle of tumor cell proliferation, tissue injury, dysregulated angiogenesis, and hypoxia promote adenosine accumulation via ATP catabolism. Adenosine receptor (eg, A2AR, A2BR) stimulation of both the innate and adaptive cellular precursors lead to immunosuppressive phenotypic differentiation. Preclinical work in various tumor models with adenosine receptor inhibition has demonstrated restoration of immune cell function and tumor regression. Given the broad activity but known limitations of anti-programmed cell death protein (PD1) therapy and other checkpoint inhibitors, ongoing studies have sought to augment the successful outcomes of anti-PD1 therapy with combinatorial approaches, particularly adenosine signaling blockade. Preliminary data have demonstrated an optimal safety profile and enhanced overall response rates in several early phase clinical trials with A2AR and more recently CD73 inhibitors. However, beneficial outcomes for both monotherapy and combinations have been mostly lower than expected based on preclinical studies, indicating a need for more nuanced patient selection or biomarker integration that might predict and optimize patient outcomes. In the context of known immuno-oncology biomarkers such as tumor mutational burden and interferon-associated gene expression, a comparison of adenosine-related gene signatures associated with clinical response indicates an underlying biology related to immunosuppression, angiogenesis, and T cell inflammation. Importantly, though, adenosine associated gene expression may point to a unique intratumoral phenotype independent from IFN-γ related pathways. Here, we discuss the cellular and molecular mechanisms of adenosine-mediated immunosuppression, preclinical investigation of adenosine signaling blockade, recent response data from clinical trials with A2AR, CD73, CD39 and PD1/L1 inhibitors, and ongoing development of predictive gene signatures to enhance combinatorial immune-based therapies.

Published
2022

15. Lipid-Oxidizing B Cells Enable Successful Vaccine Response Despite Immunosuppression

Author

Elizabeth Thompson, Katerina Roznik, Andrew H. Karaba, Katherine Cascino, Luca Biavati, Laura A. Sena, Santosh Dahkal, Wabathi Ngecu, Aura T. Abedon, Jennifer L. Alejo, Sabra Klein, Daniel S. Warren, Samuel B. Warner, Caroline X. Qin, Jonathan Mitchell, Teresa Po-Yu Chiang, Allan B. Massie, Jacqueline M. Garonzik-Wang, Brian J. Boyarsky, Joel N. Blankson, Yolanda Eby, Robert D. Leone, Michael J. Wolfgang, Erika L. Pearce, Edward J. Pearce, Christine M. Durand, Dorry Segev, Aaron A.R. Tobian, William A. Werbel, Andrea L. Cox, and Justin Bailey

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2022

17. Abstract 2115: Glutamine blockade via prodrug JHU083 reprograms immunosuppressive tumor associated macrophages (TAMs) and drives tumor immunity in urologic cancers

Author

Monali Praharaj, Fan Shen, Liang Zhao, Thomas R. Nirschl, Laura Sena, Alok K. Singh, Debebe Theodros, Xiaoxu Wang, Raekwon A. Williams, Elizabeth Thompson, Ada Tam, Srinivasan Yegnasubramanian, Robert D. Leone, Jesse Al, Rana Rais, Barbara S. Slusher, Drew M. Pardoll, Jonathan D. Powell, and Jelani C. Zarif

Subjects
Cancer Research, Oncology
Abstract

Introduction: Metastatic prostate cancer is currently incurable and kills more than 30,000 men in the United States each year, making it the second leading cancer related cause of death and an area of unmet need. Previously, we reported increased infiltration of immunosuppressive CD206-positive tumor associated macrophages (TAMs) with disease progression in prostate adenocarcinoma.[1] Glutamine metabolism has been implicated in immunosuppressive TAMs as well as metastatic castration resistant prostate cancer (mCRPC)[2] and radioresistant urothelial carcinoma.[3] As such, we hypothesize that rational metabolic interventions could be a promising strategy to simultaneously target both TAMs and cancer cells, resulting in anti-tumor immunity. Methods: We utilized a novel pro-drug (JHU083) derived from 6-Diazo-5-oxo-L-norleucine (DON) which has significantly lowered toxicity to treat two urological syngeneic immunogenic mouse tumor models in vivo; B6CaP (prostate cancer) and MB49 (bladder cancer). We studied the direct effect on tumor cells, as well as the required immune compartment for drug efficacy in vivo using antibody targeted depletions or adoptively transferred TAMs. Moreover, we used RNA-sequencing and multi-parameter flow cytometry to characterize the effect of JHU083 on TAMs transcriptional programming and proteomic expression profiles in vivo. Lastly, we assessed the phagocytotic capacity of macrophages after treatment with JHU083 with flow cytometry and immunofluorescence (IF) microscopy. Results: JHU083 treatment showed significant tumor regression in both urologic cancer models. Using in vivo depletion of CD4 or CD8 T cells, or adoptively transferring previously in-vivo JHU083 treated TAMs we established a direct anti-tumor role of TAMs. These TAMs were more inflammatory as shown by the increased TNF-positivity. Strikingly, in the TME we also observed an increase of Glut1 and Hexokinase II indicating metabolic reprogramming of these TAMs towards glycolytic phenotype. Importantly, JHU083-treated TAMs showed significantly increased phagocytic activity of cancer cells, providing direct evidence of functional reprogramming. Conclusion: We found that JHU083 has two distinct functions in vivo; first, it directly impairs cancer cells which are glutamine dependent and second, it reprograms TAMs from an immunosuppressive to an inflammatory state via antagonism of glutamine metabolism in vivo. These macrophages convert to a highly glycolytic state, have increased TNF production, and have improved phagocytic activity against tumor cells. As urologic cancers are heavily infiltrated with immunosuppressive TAMs, JHU083 is an excellent preclinical candidate for these diseases. It remains to be seen if JHU083 treatment can be effectively combined with checkpoint therapy to elicit durable anti-tumor immunity. Citation Format: Monali Praharaj, Fan Shen, Liang Zhao, Thomas R. Nirschl, Laura Sena, Alok K. Singh, Debebe Theodros, Xiaoxu Wang, Raekwon A. Williams, Elizabeth Thompson, Ada Tam, Srinivasan Yegnasubramanian, Robert D. Leone, Jesse Al, Rana Rais, Barbara S. Slusher, Drew M. Pardoll, Jonathan D. Powell, Jelani C. Zarif. Glutamine blockade via prodrug JHU083 reprograms immunosuppressive tumor associated macrophages (TAMs) and drives tumor immunity in urologic cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2115.

Published
2022

18. Broadband Multi-wavelength Properties of M87 during the 2017 Event Horizon Telescope Campaign

Author

Algaba, J.C. Anczarski, J. Asada, K. Baloković, M. Chandra, S. Cui, Y.-Z. Falcone, A.D. Giroletti, M. Goddi, C. Hada, K. Haggard, D. Jorstad, S. Kaur, A. Kawashima, T. Keating, G. Kim, J.-Y. Kino, M. Komossa, S. Kravchenko, E.V. Krichbaum, T.P. Lee, S.-S. Lu, R.-S. Lucchini, M. Markoff, S. Neilsen, J. Nowak, M.A. Park, J. Principe, G. Ramakrishnan, V. Reynolds, M.T. Sasada, M. Savchenko, S.S. Williamson, K.E. Akiyama, K. Alberdi, A. Alef, W. Anantua, R. Azulay, R. Baczko, A.-K. Ball, D. Barrett, J. Bintley, D. Benson, B.A. Blackburn, L. Blundell, R. Boland, W. Bouman, K.L. Bower, G.C. Boyce, H. Bremer, M. Brinkerink, C.D. Brissenden, R. Britzen, S. Broderick, A.E. Broguiere, D. Bronzwaer, T. Byun, D.-Y. Carlstrom, J.E. Chael, A. Chan, C.-K. Chatterjee, S. Chatterjee, K. Chen, M.-T. Chen, Y. Chesler, P.M. Cho, I. Christian, P. Conway, J.E. Cordes, J.M. Crawford, T.M. Crew, G.B. Cruz-Osorio, A. Davelaar, J. De Laurentis, M. Deane, R. Dempsey, J. Desvignes, G. Dexter, J. Doeleman, S.S. Eatough, R.P. Falcke, H. Farah, J. Fish, V.L. Fomalont, E. Ford, H.A. Fraga-Encinas, R. Friberg, P. Fromm, C.M. Fuentes, A. Galison, P. Gammie, C.F. García, R. Gentaz, O. Georgiev, B. Gold, R. Gómez, J.L. Gómez-Ruiz, A.I. Gu, M. Gurwell, M. Hecht, M.H. Hesper, R. Ho, L.C. Ho, P. Honma, M. Huang, C.-W.L. Huang, L. Hughes, D.H. Ikeda, S. Inoue, M. Issaoun, S. James, D.J. Jannuzi, B.T. Janssen, M. Jeter, B. Jiang, W. Jiménez-Rosales, A. Johnson, M.D. Jung, T. Karami, M. Karuppusamy, R. Kettenis, M. Kim, D.-J. Kim, J. Kim, J. Koay, J.Y. Kofuji, Y. Koch, P.M. Koyama, S. Kramer, M. Kramer, C. Kuo, C.-Y. Lauer, T.R. Levis, A. Li, Y.-R. Li, Z. Lindqvist, M. Lico, R. Lindahl, G. Liu, J. Liu, K. Liuzzo, E. Lo, W.-P. Lobanov, A.P. Loinard, L. Lonsdale, C. Macdonald, N.R. Mao, J. Marchili, N. Marrone, D.P. Marscher, A.P. Martí-Vidal, I. Matsushita, S. Matthews, L.D. Medeiros, L. Menten, K.M. Mizuno, I. Mizuno, Y. Moran, J.M. Moriyama, K. Moscibrodzka, M. Müller, C. Musoke, G. Mejías, A.M. Nagai, H. Nagar, N.M. Nakamura, M. Narayan, R. Narayanan, G. Natarajan, I. Nathanail, A. Neri, R. Ni, C. Noutsos, A. Okino, H. Olivares, H. Ortiz-León, G.N. Oyama, T. Ozel, F. Palumbo, D.C.M. Patel, N. Pen, U.-L. Pesce, D.W. Piétu, V. Plambeck, R. Popstefanija, A. Porth, O. Pötzl, F.M. Prather, B. Preciado-López, J.A. Psaltis, D. Pu, H.-Y. Rao, R. Rawlings, M.G. Raymond, A.W. Rezzolla, L. Ricarte, A. Ripperda, B. Roelofs, F. Rogers, A. Ros, E. Rose, M. Roshanineshat, A. Rottmann, H. Roy, A.L. Ruszczyk, C. Rygl, K.L.J. Sánchez, S. Sánchez-Arguelles, D. Savolainen, T. Schloerb, F.P. Schuster, K.-F. Shao, L. Shen, Z. Small, D. Sohn, B.W. Soohoo, J. Sun, H. Tazaki, F. Tetarenko, A.J. Tiede, P. Tilanus, R.P.J. Titus, M. Toma, K. Torne, P. Trent, T. Traianou, E. Trippe, S. Van Bemmel, I. Van Langevelde, H.J. Van Rossum, D.R. Wagner, J. Ward-Thompson, D. Wardle, J. Weintroub, J. Wex, N. Wharton, R. Wielgus, M. Wong, G.N. Wu, Q. Yoon, D. Young, A. Young, K. Younsi, Z. Yuan, F. Yuan, Y.-F. Zensus, J.A. Zhao, G.-Y. Zhao, S.-S. Principe, G. Giroletti, M. D'Ammando, F. Orienti, M. Abdalla, H. Adam, R. Aharonian, F. Benkhali, F.A. Angüner, E.O. Arcaro, C. Armand, C. Armstrong, T. Ashkar, H. Backes, M. Baghmanyan, V. Barbosa Martins, V. Barnacka, A. Barnard, M. Becherini, Y. Berge, D. Bernlöhr, K. Bi, B. Böttcher, M. Boisson, C. Bolmont, J. De Bony De Lavergne, M. Breuhaus, M. Brun, F. Brun, P. Bryan, M. Büchele, M. Bulik, T. Bylund, T. Caroff, S. Carosi, A. Casanova, S. Chand, T. Chen, A. Cotter, G. Curyło, M. Damascene Mbarubucyeye, J. Davids, I.D. Davies, J. Deil, C. Devin, J. Dewilt, P. Dirson, L. Djannati-Ataï, A. Dmytriiev, A. Donath, A. Doroshenko, V. Duffy, C. Dyks, J. Egberts, K. Eichhorn, F. Einecke, S. Emery, G. Ernenwein, J.-P. Feijen, K. Fegan, S. Fiasson, A. De Clairfontaine, G.F. Fontaine, G. Funk, S. Füßling, M. Gabici, S. Gallant, Y.A. Giavitto, G. Giunti, L. Glawion, D. Glicenstein, J.F. Gottschall, D. Grondin, M.-H. Hahn, J. Haupt, M. Hermann, G. Hinton, J.A. Hofmann, W. Hoischen, C. Holch, T.L. Holler, M. Hörbe, M. Horns, D. Huber, D. Jamrozy, M. Jankowsky, D. Jankowsky, F. Jardin-Blicq, A. Joshi, V. Jung-Richardt, I. Kasai, E. Kastendieck, M.A. Katarzyński, K. Katz, U. Khangulyan, D. Khélifi, B. Klepser, S. Kluźniak, W. Komin, N. Konno, R. Kosack, K. Kostunin, D. Kreter, M. Lamanna, G. Lemiere, A. Lemoine-Goumard, M. Lenain, J.-P. Levy, C. Lohse, T. Lypova, I. Mackey, J. Majumdar, J. Malyshev, D. Malyshev, D. Marandon, V. Marchegiani, P. Marcowith, A. Mares, A. Martí-Devesa, G. Marx, R. Maurin, G. Meintjes, P.J. Meyer, M. Moderski, R. Mohamed, M. Mohrmann, L. Montanari, A. Moore, C. Morris, P. Moulin, E. Muller, J. Murach, T. Nakashima, K. Nayerhoda, A. De Naurois, M. Ndiyavala, H. Niederwanger, F. Niemiec, J. Oakes, L. O'Brien, P. Odaka, H. Ohm, S. Olivera-Nieto, L. De Ona Wilhelmi, E. Ostrowski, M. Panter, M. Panny, S. Parsons, R.D. Peron, G. Peyaud, B. Piel, Q. Pita, S. Poireau, V. Noel, A.P. Prokhorov, D.A. Prokoph, H. Pühlhofer, G. Punch, M. Quirrenbach, A. Rauth, R. Reichherzer, P. Reimer, A. Reimer, O. Remy, Q. Renaud, M. Rieger, F. Rinchiuso, L. Romoli, C. Rowell, G. Rudak, B. Ruiz-Velasco, E. Sahakian, V. Sailer, S. Sanchez, D.A. Santangelo, A. Sasaki, M. Scalici, M. Schutte, H.M. Schwanke, U. Schwemmer, S. Seglar-Arroyo, M. Senniappan, M. Seyffert, A.S. Shafi, N. Shiningayamwe, K. Simoni, R. Sinha, A. Sol, H. Specovius, A. Spencer, S. Spir-Jacob, M. Stawarz, Ł. Sun, L. Steenkamp, R. Stegmann, C. Steinmassl, S. Steppa, C. Takahashi, T. Tavernier, T. Taylor, A.M. Terrier, R. Tiziani, D. Tluczykont, M. Tomankova, L. Trichard, C. Tsirou, M. Tuffs, R. Uchiyama, Y. Van Der Walt, D.J. Van Eldik, C. Van Rensburg, C. Van Soelen, B. Vasileiadis, G. Veh, J. Venter, C. Vincent, P. Vink, J. Völk, H.J. Vuillaume, T. Wadiasingh, Z. Wagner, S.J. Watson, J. Werner, F. White, R. Wierzcholska, A. Wong, Y.W. Yusafzai, A. Zacharias, M. Zanin, R. Zargaryan, D. Zdziarski, A.A. Zech, A. Zhu, S.J. Zorn, J. Zouari, S. Żywucka, N. Acciari, V.A. Ansoldi, S. Antonelli, L.A. Engels, A.A. Artero, M. Asano, K. Baack, D. Babić, A. Baquero, A. De Almeida, U.B. Barrio, J.A. Becerra González, J. Bednarek, W. Bellizzi, L. Bernardini, E. Bernardos, M. Berti, A. Besenrieder, J. Bhattacharyya, W. Bigongiari, C. Biland, A. Blanch, O. Bonnoli, G. Bošnjak, Ž. Busetto, G. Carosi, R. Ceribella, G. Cerruti, M. Chai, Y. Chilingarian, A. Cikota, S. Colak, S.M. Colombo, E. Contreras, J.L. Cortina, J. Covino, S. D'Amico, G. D'Elia, V. Da Vela, P. Dazzi, F. De Angelis, A. De Lotto, B. Delfino, M. Delgado, J. Delgado Mendez, C. Depaoli, D. Di Pierro, F. Di Venere, L. Do Souto Espineira, E. Dominis Prester, D. Donini, A. Dorner, D. Doro, M. Elsaesser, D. Fallah Ramazani, V. Fattorini, A. Ferrara, G. Fonseca, M.V. Font, L. Fruck, C. Fukami, S. García López, R.J. Garczarczyk, M. Gasparyan, S. Gaug, M. Giglietto, N. Giordano, F. Gliwny, P. Godinović, N. Green, J.G. Green, D. Hadasch, D. Hahn, A. Heckmann, L. Herrera, J. Hoang, J. Hrupec, D. Hütten, M. Inada, T. Inoue, S. Ishio, K. Iwamura, Y. Jiménez, I. Jormanainen, J. Jouvin, L. Kajiwara, Y. Karjalainen, M. Kerszberg, D. Kobayashi, Y. Kubo, H. Kushida, J. Lamastra, A. Lelas, D. Leone, F. Lindfors, E. Lombardi, S. Longo, F. López-Coto, R. López-Moya, M. López-Oramas, A. Loporchio, S. Machado De Oliveira Fraga, B. Maggio, C. Majumdar, P. Makariev, M. Mallamaci, M. Maneva, G. Manganaro, M. Mannheim, K. Maraschi, L. Mariotti, M. Martínez, M. Mazin, D. Menchiari, S. Mender, S. Mićanović, S. Miceli, D. Miener, T. Minev, M. Miranda, J.M. Mirzoyan, R. Molina, E. Moralejo, A. Morcuende, D. Moreno, V. Moretti, E. Neustroev, V. Nigro, C. Nilsson, K. Nishijima, K. Noda, K. Nozaki, S. Ohtani, Y. Oka, T. Otero-Santos, J. Paiano, S. Palatiello, M. Paneque, D. Paoletti, R. Paredes, J.M. Pavletić, L. Penil, P. Perennes, C. Persic, M. Moroni, P.G.P. Prandini, E. Priyadarshi, C. Puljak, I. Rhode, W. Ribó, M. Rico, J. Righi, C. Rugliancich, A. Saha, L. Sahakyan, N. Saito, T. Sakurai, S. Satalecka, K. Saturni, F.G. Schleicher, B. Schmidt, K. Schweizer, T. Sitarek, J. Šnidarić, I. Sobczynska, D. Spolon, A. Stamerra, A. Strom, D. Strzys, M. Suda, Y. Surić, T. Takahashi, M. Tavecchio, F. Temnikov, P. Terzić, T. Teshima, M. Tosti, L. Truzzi, S. Tutone, A. Ubach, S. Van Scherpenberg, J. Vanzo, G. Vazquez Acosta, M. Ventura, S. Verguilov, V. Vigorito, C.F. Vitale, V. Vovk, I. Will, M. Wunderlich, C. Zarić, D. Adams, C.B. Benbow, W. Brill, A. Capasso, M. Christiansen, J.L. Chromey, A.J. Daniel, M.K. Errando, M. Farrell, K.A. Feng, Q. Finley, J.P. Fortson, L. Furniss, A. Gent, A. Giuri, C. Hassan, T. Hervet, O. Holder, J. Hughes, G. Humensky, T.B. Jin, W. Kaaret, P. Kertzman, M. Kieda, D. Kumar, S. Lang, M.J. Lundy, M. Maier, G. Moriarty, P. Mukherjee, R. Nieto, D. Nievas-Rosillo, M. O'Brien, S. Ong, R.A. Otte, A.N. Patel, S. Pfrang, K. Pohl, M. Prado, R.R. Pueschel, E. Quinn, J. Ragan, K. Reynolds, P.T. Ribeiro, D. Richards, G.T. Roache, E. Rulten, C. Ryan, J.L. Santander, M. Sembroski, G.H. Shang, R. Weinstein, A. Williams, D.A. Williamson, T.J. Hirota, T. Cui, L. Niinuma, K. Ro, H. Sakai, N. Sawada-Satoh, S. Wajima, K. Wang, N. Liu, X. Yonekura, Y.

Subjects
Astrophysics::High Energy Astrophysical Phenomena, Astrophysics::Cosmology and Extragalactic Astrophysics
Abstract

In 2017, the Event Horizon Telescope (EHT) Collaboration succeeded in capturing the first direct image of the center of the M87 galaxy. The asymmetric ring morphology and size are consistent with theoretical expectations for a weakly accreting supermassive black hole of mass ∼6.5 × 109 M o˙. The EHTC also partnered with several international facilities in space and on the ground, to arrange an extensive, quasi-simultaneous multi-wavelength campaign. This Letter presents the results and analysis of this campaign, as well as the multi-wavelength data as a legacy data repository. We captured M87 in a historically low state, and the core flux dominates over HST-1 at high energies, making it possible to combine core flux constraints with the more spatially precise very long baseline interferometry data. We present the most complete simultaneous multi-wavelength spectrum of the active nucleus to date, and discuss the complexity and caveats of combining data from different spatial scales into one broadband spectrum. We apply two heuristic, isotropic leptonic single-zone models to provide insight into the basic source properties, but conclude that a structured jet is necessary to explain M87's spectrum. We can exclude that the simultaneous γ-ray emission is produced via inverse Compton emission in the same region producing the EHT mm-band emission, and further conclude that the γ-rays can only be produced in the inner jets (inward of HST-1) if there are strongly particle-dominated regions. Direct synchrotron emission from accelerated protons and secondaries cannot yet be excluded. © 2021. The Author(s). Published by the American Astronomical Society..

Published
2021

19. Enhanced T cell effector function upon differentiation of CD8+ and CD4+ T cells in the presence of BioE-1197 through potential off target ARK family inhibition

Author

Rachel Shannon Helms, Chirag H. Patel, Robert D. Leone, Bridget Duvall, Run-Duo Gao, Takashi Tsukamoto, Barbara S. Slusher, Joel L. Pomerantz, and Jonathan D Powell

Subjects
Immunology, Immunology and Allergy
Abstract

We sought to evaluate PAS domain containing kinase (PASK) inhibition during T cell differentiation using the previously described PASK inhibitor BioE-1197. Notably, CD8+, Th1, and Th2 T cells activated and expanded in the presence of BioE-1197 display elevated lineage specific cytokine production upon restimulation compared to control differentiated T cells, suggesting BioE-1197 may prove to be a powerful means to enhance T cell function. Curiously however, BioE-1197 mediated these effects even in PASK KO T cells suggesting its mechanism of action was independent of PASK. BLAST alignment of the PASK kinase domain revealed members of the AMPK related kinases (ARK) family as potential targets of BioE-1197. ARKs phosphorylate class IIa histone deacetylases (HDACs) in response to activation. To assess whether BioE-1197 inhibits ARK family member activity, we activated and expanded CD8+ T cells with or without BioE-1197. Control differentiated CD8s show elevated phosphorylated and total HDAC7 over time after activation. However, BioE-1197 differentiated cells do not exhibit elevated phosphorylation or total expression of HDAC7 after activation. Concurrent reduction of phosphorylation and total HDAC7 is a phenotype previously reported in cells treated with ARK family kinase inhibitors, suggesting BioE-1197 may be functioning to inhibit an ARK family member(s). Ongoing work aims to definitively demonstrate that the ability of BioE-1197 to enhance effector function is via inhibition of ARK family members and the subsequent regulation of HDAC7. Overall these studies identify BioE-1197 as a novel agent to enhance effector T cell function and suggests potential utility in tumor immunotherapy and enhancing vaccine efficacy. Supported by grants from NIH (P41EB028239-03, R01AI077610-10) and the Bloomberg-Kimmel Institute for Cancer Immunotherapy.

Published
2022

21. Change behaviour and raise awareness about the Adriatic’s underwater treasures as common goods: the UnderwaterMuse Project

Author

R. Auriemma, C. Beltrame, I. Kamenjarin, D. Leone, I. Šuta, M. Turchiano, Auriemma, R., Beltrame, C., Kamenjarin, I., Leone, D., Šuta, I., and Turchiano, M.

Subjects
Settore L-ANT/10 - Metodologie della Ricerca Archeologica, UnderwaterMuse Interreg Italia-Croatia Project, valorization, accessibility, underwater archaeology, underwater cultural heritage, in situ preservation, underwater park / path, VR, GIS
Abstract

The project aims at applying on sample areas (maritime landscapes of Torre Santa Sabina, Grado, Resnik/Siculi, Caorle) a methodological and technological protocol based on research/ knowledge and development/communication of an underwater archeological site that is complex and multi-stratified, characterized by strong diversity. The project’s objective is therefore to transform the site into an underwater archaeological park (or eco-museum) through innovative and/or experimental methodologies and techniques in order to try to reduce the loss of important cultural heritages as well as to guarantee an economic spin-off deriving directly from the creation of a sector linked to the tourist-cultural promotion of the context of reference. UnderwaterMuse will target local communities as long-term keepers of vitality at tourist destinations, promote co-creative partnerships among tourism and cultural actors, public decision makers, creative companies, associations of citizens, facilitating exchange of information. An immersive VR approach renders underwater sites accessible to a wider public, including people with different kinds of disabilities. Building capacity for professionals already working in this field will help them adapt to a “museum for all” concept, in spite of limited organizational or financial resources.Training diving guides will improve the immersive experience of underwater sites. Regional action plans will enhance environmental management and preservation of coastal areas harbouring those sites. Based on the gained experience, an innovative promotional GIS tool, the ‘UnderwaterMuse MAP’ for promoting underwater sites with accessibility standards, will be developed. The ‘UnderwaterMuse MAP’ will be promoted at transnational, national and local level, in the Adriatic and beyond, thus guaranteeing its sustainability and transferability during and after its implementation. The interdisciplinary partnership from 4 different regions will carry on pilot actions focusing on transform sites with a strong potential as experience-based tourist destinations testing a sustainable tourist offer in areas less interested by major tourist flows.

Published
2020

22. Duchenne muscular dystrophy: Preliminary experience with sacubitril-valsartan in patients with asymptomatic left ventricular dysfunction

Author

P, Lamendola, G A, Lanza, V, Melita, A, Villano, C, Palermo, D, Leone, A, Lombardo, F, Pennestrì, F, Crea, E M, Mercuri, and M, Pane

Subjects
Adult, Duchenne muscular, Left ventricular dysfunction, Maximum Tolerated Dose, Aminobutyrates, Biphenyl Compounds, Dystrophy, Muscular Dystrophy, Duchenne, Angiotensin Receptor Antagonists, Drug Combinations, Ventricular Dysfunction, Left, Young Adult, Echocardiography, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Humans, Valsartan, Sacubitril/valsartan
Abstract

Duchenne muscular dystrophy (DMD) is an inherited X-linked recessive neuromuscular disease caused by mutations of the dystrophin gene, leading to early and progressive muscle deterioration and dilated cardiomyopathy. The aim of this investigation was to assess whether treatment with sacubitril/valsartan (S/V) is well tolerated and may have beneficial effects in DMD patients with left ventricle (LV) dysfunction.We administered S/V to 3 DMD patients (19-29 yeard old) with LV ejection fraction35% at echocardiography but no symptoms of heart failure. All patients were on optimal medical therapy. S/V was initiated at a very low dose of 12/13 mg/die, after withdrawal of angiotensin-converting enzyme inhibitor therapy, and slowly titrated to the dose of 49/51 mg twice daily or the maximally tolerated dose. Clinical and echocardiographic follow-up was performed after 3, 6 and 12 months.At baseline, the LV ejection fraction was 32±1%. A significant improvement of LV ejection fraction was observed at 3 months (44.0±6.0%; p0.05), which was maintained at 6 (45.7±5.0%) and 12 (43.3±3.2%) months (p0.05 for both). No relevant side effects were reported throughout the period of the study.Our preliminary data suggest that, in DMD patients with reduced LV ejection fraction, S/V is safe and may improve LV function.

Published
2020

23. Impact of rock fracture geometry on geotechnical barrier integrity – A numerical study

Author

Ivars Neretnieks, Luis Moreno, Michael Trumm, Achim Wenka, D. Leone, Thorsten Schäfer, and Florian Huber

Subjects
Aperture, Flow (psychology), 0211 other engineering and technologies, 02 engineering and technology, Geotechnical Engineering and Engineering Geology, Standard deviation, Darcy–Weisbach equation, Flow velocity, Erosion, Fracture (geology), Mean flow, Geotechnical engineering, Geology, 021102 mining & metallurgy, 021101 geological & geomatics engineering
Abstract

The effect of fracture geometry on bentonite erosion for a generic repository site in crystalline host rock environment was investigated by means of 2-d numerical simulations. Fracture geometry was varied systematically using random aperture normal distributions with a mean aperture of 1 mm and standard deviations between 0 and 0.7 mm, respectively. Moreover, two aperture correlation lengths (0.2 m and 2 m) were applied. Based on the synthetic fracture aperture fields generated the cubic law in conjunction with the Darcy equation is used to simulate fracture flow fields for mean flow velocities in the fracture between 1 × 10 −5 m/s and 1 × 10−7 m/s. These flow fields are used in a two-way coupling approach to bentonite erosion simulations. The results of the study clearly show the influence of variable fracture aperture on bentonite erosion behaviour and erosion rates (kg/a). Increasing fracture aperture standard deviation leads to increasing heterogeneous flow velocity distributions governing the erosion behaviour and erosion rates. Calculated steady state erosion rates are in the range of ~0.25 kg/a down to ~0.014 kg/a. The highest erosion rate is calculated for the highest mean flow velocity in conjunction with the highest standard deviation. The effect of aperture heterogeneity diminishes for the lowest flow velocities. In summary, the results show the effect of fracture heterogeneity on bentonite erosion, especially for high to medium mean flow velocities combined with high to medium fracture heterogeneity under the model boundary conditions and model capabilities and limitations considered. An increase of up to ~83% in erosion rate compared to the constant aperture case highlights the need to consider fracture aperture heterogeneity and its effect on the bentonite erosion in the assessment of the safety and evolution of a high-level nuclear waste repository.

Published
2021

24. VIEWING ONLY POSTERS1323Evaluation of right ventricular transverse strain and strain rate in patients with acute ST-segment elevation myocardial infarction: a cardiac magnetic resonance feature tracking study1333Cardiac resynchronization in ischemic heart failure patients: a comparison between therapy guided by cardiac magnetic resonance imaging and 2D-speckle tracking echocardiography1338Cardiac magnetic resonance versus bisphosphonate scintigraphy for diagnosis of cardiac amyloidosis1341Strain relaxation index, a novel tagged MRI-derived diastolic function parameter, is impaired in metabolic syndrome1349Global Longitudinal Strain Predicts Chronic Myocardial Infarction in Patients with Normal Ejection Fraction1352Optimal Dose Of Dobutamine During Low-Dose Dobutamine Stress Echocardiography In Correctly Identify Viable Segments On Cardiovascular Magnetic Resonance1368Absolute wall thickening and left ventricular ejection fraction–a unifying theory of myocardial contraction and heart failure?1376Transient St Elevation in Acs Like Myocarditis1379Patients after Fontan with a 'total cavopulmonary connection' Fontan modification develop more collateral flow compared to 'old-fashioned' Fontan modifications1387A MRI–derived 3D patient specific model for fibrosis quantification in atrial fibrillation1391Scar burden and survival in patients with ischemic cardiomyopathy and poor LV ejection fraction1392Relation of inflammatory markers with myocardial and microvascular injury in patients with reperfused ST- elevation myocardial infarction1406Equivalence of segmented conventional and fast single-shot late gadolinium enhancement (LGE) techniques for1410Cardiac Mri Appearances of Tuberculosis - A Review of Varied Presentations in India1415Atheroma burden, cardiac remodelling and epicardial fat: A comparison between healthy South Asian and European adults using Whole Body Cardiovascular MR1418Symptomatic Ventricular Arrhythmias: Diagnostic Yield of Cardiac Magnetic Resonance1421CMR assessment of aortic stiffness in asymptomatic low risk patients with type 2 diabetes mellitus1436Shock index as a predictor of myocardial damage and clinical outcome in ST-elevation myocardial infarction1451Combined biomarker testing for the prediction of microvascular obstruction after primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction1452A novel oscillometric technique compared with cardiac magnetic resonance for the assessment of aortic pulse wave velocity in ST-segment elevation myocardial infarction1456Aorto-pulmonary collaterals evaluated by CMR is associated to reduced 'effective' cardiac index late after Fontan palliation1458Evaluation of pulmonary transit time and Pulmonary Blood Volume with first-pass perfusion CMR imaging in adult with repaired Congenital Heart disease1459Prognostic value of the cardiac magnetic resonance as a predictor of improvement in ventricular function after TakoTsubo syndrome1462Diagnostic performance of ECG detection of left atrial enlargement in patients with arterial hypertension relative to the cardiac magnetic resonance gold-standard: impact of obesity1463Utility of cardiac magnetic resonance imaging for diagnosis of cardiac sarcoidosis and prediction of therapeutic effects in patients with complete heart block and implanted magnetic resonance-conditional pacemaker: A multicenter study1467Cardiac magnetic resonance late gadolinium enhancement in patients with genetic dilated cardiomyopathy14712.Left ventricular hypertrophy in hypertensive patients–comparison of Cardiac Magnetic Resonance and Echocardiographic analysis of morphological and functional LV-parameters1472Is Angiographic Perfusion Score assessed in patients with acute myocardial infarction correlated with Cardiac Magnetic Resonance infarct size and N-terminal pro-brain natriuretic peptide in 6-month follow-up1476Cardiac Magnetic Resonance Patterns of Left Ventricular Diastolic Function In Hypertrophic Cardiomyopathy1477Impact of platelet volume on thrombus burden and tissue reperfusion in patients with STEMI treated with primary angioplasty: MRI study1479Right ventricle systolic function assessment and its prognostic implications in cardiac amyloidosis1484Cardiac MRI - an important tool in the evaluation of multsystemic inflamatory diseases. An Erdheim-Chester Disease case report1485Predictive value of cardiac magnetic resonance for future adverse cardiac events in patients with ST-segment elevation myocardial infarction1486Time-to-treatment but not thrombectomy influence infarct size and microvascular obstruction in patients with acute ST-segment elevation myocardial infarction treated with primary coronary intervention1489Primary PCI versus Early Routine Post Fibrinolysis PCI for ST Elevation Myocardial Infarction1490Evaluation of ventricular function in Fontan patients undergoing feature tracking magnetic resonance strain1491Impacts of atrialized right ventricle and left ventricular displacement in Ebstein's anomaly on left ventricular function assessed by cardiovascular MRI1494Final diagnosis for patients presenting with chest pain, electrocardiographic changes or troponin rise and normal coronary arteries: insights from Cardiovascular MRI in our population1495Early Predictive Factors of LV Remodeling after STEMI; Assessment by Coronary Angiogram and Cadiovascular Magnetic Resonance1497The Pathobiologic Mechanisms and the Prognostic Meaning of t wave Inversion in Acute Myocarditis. a Study Performed by Cardiac Magnetic Resonance1501The Influence of Left Atrial Function on Exercise Tolerance in Patients with Heart Failure and Preserved Ejection Fraction: A Cardiac Magnetic Resonance Feature Tracking Study1504Microvascular Obstruction in Patients with Anterior ST-Elevation Myocardial Infarction who Underwent Primary Percutaneous Coronary Intervention: Predictors and Impact on the Left Ventricular Function1508Histological Validation of ECV Quantification by Cardiac Magnetic Resonance T1 Mapping in Cardiac Amyloidosis1513Comparative Evaluation of Flow Quantification Across the Atrioventricular Valve in Patients with Functional Univentricular Heart After Fontan's Surgery and Healthy Controls: Measurement by 4D Flow Magnetic Resonance Imaging and Streamline Visualization1515Does arterial switch for d-transposition of the great arteries alter myocardial deformation of the ventricles?1527Accuracy of T1 Mapping by multi-professional CMR operators to predict myocardial infarct1531Detecting hypertensive heart disease: the additive value of cardiovascular magnetic resonance imaging1534Diagnostic Performance of Cardiac Magnetic Resonance Strain Parameters in Assesment of Myocardial Ischemia1535Relationships between left ventricular filling pressures and longitudinal dysfunction with myocardial fibrosis in uncomplicated hypertensive patients1539Predictive Clinical Factors of Tissue Damage Severity in Reperfused Acute Myocardial Infarction as Visualized by Cardiac Magnetic Resonance1541Which CMR derived parameter predicts better the need of invasive treatment in aortic coarctation?1543Contrast-enhanced magnetic resonance tomography in patients with supraventricular tachyarrhythmias1546Prognostic Value of CMR Imaging Biomarkers on Outcome in Peripheral Arterial Disease: a 6-year Follow-up Pilot Study1549Dobutamine-Stress-CMR in Young Adults after Arterial Switch Operation as Neonates1553Impact of posteromedial papillary muscle infarction on mitral regurgitation after ST-segment elevation myocardial infarction1556Role of cardiac magnetic resonance imaging in assessment of left ventricular hypertrophy1569Using intrinsic Cardiac Shear Waves to measure Myocardial Stiffness: Preliminary results from Patients with Heart failure with preserved Ejection Fraction1571Relationship of cerebrovascular reactivity and MRI pattern of carotid atherosclerotic plaque1577Feasibility study of an MR conditional pedal ergometer for cardiac stress MRI–preliminary results in healthy volunteers and patients with suspected coronary artery disease1581Pulmonary valve replacement for severe pulmonary stenosis has a positive effect on left ventricular remodeling1582The RV after cardiac surgery, more resilient than thought: multiparametric quantification shows altered rather than reduced function1584Usefulness of cardiovascular magnetic resonance to differentate coronary artery disease from non ischemic cardiomyoptathy in patients with heart failure1593What does CMR add to the ESC Risk Prediction Model to Assess the Occurrence of Sudden Cardiac Death in Patients with HCM?1597Detecting Progression of Diffuse Interstitial Fibrosis in Alstrom Syndrome1612Diffuse fibrosis in the ventricles of patients with transposition of great arteries late after atrial switch1631Utility of Cardiac Magnetic Resonance in the diagnosis and stratification of arrhythmic risk in patients with confirmed or suspected ventricular arrhythmias1635Size matters: pulmonary veins geometry by cardiac magnetic resonance imaging in atrial fibrillation patients1642How do the differences in Left Ventricular wall measurements from Echocardiography and CMR in patients with Hypertrophic Cardiomyopathy affect current Sudden Cardiac Death Risk Scores?1651Noninvasive assessment of intracardiac viscous energy loss in Fontan patients from 4D Flow CMR1653Behcet and Myocardial Infarction: A Rare Combination1328Impact of New Cerebral Ischemic Lesions On the Occurrence of Delirium after Transcatheter Aortic Valve Implantation1329Heart T2* assessment to measure iron overload using different software tools in patients with Thalassemia Major1332Hypertrabeculated Left Ventricle at Cardiac Magnetic Resonance Imaging: β-Thalassemia Major vs. Left Ventricular Non -Compaction Disease1335Aortic Regurgitation following Transcatheter Aortic Valve Implantation (TAVI): a CMR Study of two prosthesis designs1336Incremental value of semi-quantitative evaluation of myocardium perfusion with 3T stress cardiac MRI1343Left ventricular morphological quantification with single shot and free-breathing SSFP cine imaging compared with standard breath-hold SSFP cine imaging1344Changes of cardiac iron and function during pregnancy in transfusion-dependent thalassemia patients1346Significant improvement of survival by T2* MRI in thalassemia major1350The impact of trans-catheter aortic valve implantation induced left-bundle branch block on cardiac reverse remodelling1351Value of magnetic resonance myocardial perfusion imaging in patients with indeterminate coronary computed tomography angiography results1353Gender differences in response to Transcatheter Aortic Valve implantation in patients with severe aortic stenosis assessed by feature tracking1354A qualitative assessment of first-pass perfusion bolus timings in the assessment of myocardial ischemia: A magnetic resonance study1355MRI prospective survey on cardiac iron and function and on hepatic iron in non transfusion-dependent thalassemia intermedia patients treated with desferrioxamine or non chelated1358Coronary Calcification Compromises Myocardial Perfusion Irrespective of Luminal Stenosis1359Non–contrast three–dimensional magnetic resonance imaging for pre–procedural assessment of aortic annulus dimensions in patients undergoing transcatheter aortic valve implantation1360'Systolic ventricularization' of the left atrium with bileaflet mitral valve prolapse: impact on quantification of mitral regurgitation1361CMR assessment of left ventricular remodeling 6 months after percutaneous edge-to-edge repair using Mitraclip1363Accuracy of Transthoracic Echocardiography (TTE) in comparison with Cardiac Magnetic Resonance (CMR)1374CMR for myocardial iron overload assessment: a new calibration curve from the MIOT project1381Can Speckle Tracking Imaging Reveal Myocardial Iron Overload in Thalassemia Major? A Combined Echocardiography and Cardiac Magnetic Resonance Study1382Native myocardial T1 mapping in patients with pulmonary hypertension and age matched volunteers1384A Insidious Line Between Thalassemia Intermedia And Left Ventricular Non-Compaction Disease: The Role Of Cardiac Magnetic Resonance1388Pulmonary Artery : Ascending Aorta Diameter - An Important and Easily Measureable Prognostic Parameter1394Novel carotid artery ultrasound index–Extra-media thickness and a well-established cardiac magnetic resonance fat quantification method1403Validation of CMR-derived LVOT diameters against direct in-vivo measurements1409Early myocardial perfusion measured by CMR in acute myocardial infarction treated by primary PCI–a postconditioning study1420Assessment of paravalvular aortic regurgitation after transcatheter aortic valve implantation using cardiac magnetic resonance imaging: a comparative study with echocardiography and angiography1422Left atrial strain measured by feature tracking predicts left ventricular end diastolic filling pressure1426Validation of extracellular volume equation by serial cardiac magnetic resonance imaging measurements in patients with varying hematocrit1427Assessing diastolic function applying Cardiovascular Magnetic Resonance - comparison with the gold standard1475Role of Adenosine Stress Cardiac Mri in the Setting of Chronic Total Occlusion of Coronary Arteries1520Aortic Elasticity Indexes by Magnetic Resonance Predict Progression of Ascending Aorta Dilation1522Combined atrioventricular assessment of diastolic function by cardiac magnetic resonance1537Safety, image quality and clinical utility of cardiac magnetic resonance in patients with antiarrhythmic devices1538Usefulness of cardiac magnetic resonance to predict the need for surgical procedures in patients with mitral regurgitation1550Normal T1, T2, T2* and extracellular volume reference values in healthy volunteers at 3 Tesla cardiac magnetic resonance1551Comprehensive intra-ventricular myocardial deformation strain analysis in healthy volunteers: implications for regional myocardial disease processes1557Elastic properties changes of aorta in patients with dilatation of the ascending aorta evaluated by Magnetic Resonance1558The prevalence of active myocarditis assessed by cardiovascular magnetic resonance in patients with clinically suspected myocarditis1563Quantitative assessment of myocardial scar heterogeneity using texture analysis to risk stratify post–MI patients for ICD insertion1564Gender differences in exercise capacity and LV remodeling in response to pressure overload in aortic stenosis1572Myocardial wall stress as a novel CMR measure to assess cardiac function1573Feature tracking cardiac magnetic resonance to assess LV mechanics in pressure and volume overload1574Safety, feasibility and clinical impact of Cardiovascular Magnetic Resonance in patients with MR-conditional devices1576T1 Mapping at 1-Year Following Aortic Valve Replacement: Baseline Geometry Defines Magnitude of Fibrosis Regression1583Normal values of LV global myocardial mechanics using two and three-dimensional cardiovascular magnetic resonance1585Prediction of infarct transmurality in acute myocardial infarction based on cardiac magnetic resonance deformation analysis1595Measuring invasive blood pressure by catheters guided solely by Cardiovascular Magnetic Resonance by using a new guidewire without the need of a hybrid CMR-fluoroscopy suite1599Influence of active and passive cardiac implants on CMR image quality: results from a consecutive patient series1600Reproducibility of aortic 4D flow measurements in healthy volunteers1601An automatic approach to extract 4D flow hemodynamic markers: application in BAV-affected patients1602Global myocardial mechanics with 2 and 3-Dimensional cardiovascular magnetic resonance feature tracking in patients with myocarditis1603A CMR-based clinician-friendly assessment of in vivo left ventricle hemodynamics1604Reproducibility of left atrial strain using cardiovascular magnetic resonance myocardial feature tracking1605The severity of myocardial infarction in STEMI, determined by transmurality of infarct and infarct characteristics, impacts on myocardial T2 values1606MicroRNA as potential biomarkers of acute myocardial damage following STEMI1607Myocardial blush grade is associated with microvascular obstruction on CMR following STEMI16084D Flow CMR imaging: Comparison of conventional parallel imaging and variable density k-t acceleration1609In-vitro comparison of segmented-gradient-echo versus non-segmented echo planar imaging 4D Flow CMR: validation of flow volume and 3D vortex ring assessment1614Not just 2D but also 4D flow measurements in pulsatile phantom are accurate and reproducible1615Diffusion Tensor Imaging: Comparison of Hypertrophic Cardiomyopathy, Hypertension and Healthy Cohorts1624Impact of myocardial fibrosis measured by cardiac magnetic resonance imaging on reverse left ventricular remodelling after transcatheter aortic valve implantation1625Prosthetic valve regurgitation after transcatheter aortic valve implantation with new-generation devices compared to surgical aortic valve replacement–a cardiac magnetic resonance imaging flow measurement analysis1637Assessment of Aortic and Pulmonary Artery stiffness in Patients with COPD using Cardiac Magnetic Resonance1638Myocardial Mechanics implications using 2D Cardiovascular Magnetic Resonance in Aortic Regurgitation1639Delineation of myocardial infarction & viability by 12 lead ECG vs cardiac magnetic resonance1641Regional variation in native T1 values in normal healthy volunteers?1645Feasibility of myocardial strain assessment using tissue tracking at 3.0T CMR following ST-segment elevation myocardial infarction1648Diagnostic Impact of Cardiac Magnetic Resonance in patients with acute chest pain, troponin elevation and no significant angiographic coronary artery disease

Author

João Pais, Sheraz A. Nazir, Amardeep Ghosh Dastidar, GL. Alonso Salinas, Estefania De Garate, Constanze Merten, Laura-Ann McGill, Ana Beatriz Solana, Mohammed S.M. Elbaz, Kaoru Tanaka, Elisa McAlindon, R. Hinojar, Chiara Baggi, B. Berlot, Filippo Piatti, RLF. van der Palen, Sebastian Hilbert, Sohrab Fratz, F. Valente, TA. Treibel, A. Baritussio, Alessandra Scatteia, Thu-Thao Le, Anvesha Singh, TGJ Gibbs, Tomasz Brzostowicz, Katarzyna Katulska, Clotilde Roy, Begoña Igual, Begoña Igual-Muñoz, G.D. Aquaro, Giovanni Donato Aquaro, Giovanni Malanchini, J. Kermer, Siri Lagethon Heck, JRJ. Foley, Najime Bouhzam, Anne Bethke, Sajid Aslam, Maciej Haberka, Andreas A. Kammerlander, F. Macaione, Laura Saunders, F. Pizzino, A. Meloni, D. Leone, Bernard P. Paelinck, Gabriella Vincenti, Marco Barbanti, Michael Y. Henein, S. Matthew, C. Schneeweis, LE. Dobson, Antonella Meloni, C. Richmond, Chun-Ho Yun, TA. Musa, Chiodi Elisabetta, Masieh Abawi, M. Bensaoud, Vivian P. Kamphuis, Jessica Webb, Giulia Vinco, N. Shehu, S. Baig, Theano Papavassiliu, Juan Sztajzel, Menacho Katia, M.M. Winter, Agnes Mayr, A.S. Maksimova, aSara E. Fawal, Klug Gert, M. Frick, Harrie CM. van den Bosch, O.V. Mochula, B. Igual Muñoz, Begoña Igual Muñoz, Carla Contaldi, Max Charalambos, G. Bainbridge, B.E.U. Burkhardt, Hoi Lam She, Franz Duca, Ahmad A. Mahmoud, M. von Roeder, Alberto Cipriani, Arthur Cescau, Albert TEIS, Akio Inage, Sameh Mohamed Shaheen, J. Rajewska-Tabor, R. Bica, Luís Almeida-Morais, Nazario Carrabba, P. Agudo-Quílez, Agata Brzozowska-Czarnek, Alexandra Sousa, Makoto Orii, Tamas Erdei, A. Tercero Martínez, L. Ait Ali, P. Festa, Hans-Josef Feistritzer, Sebastian J. Reinstadler, Rachel Kan, Claudia Camaioni, Jonathan Weir-McCall, Zeeshan S. A. Lakhani, K. Arnhold, Martin Reindl, E. Nyktari, Maddalena Valinoti, Naira Mkrtchyan, Giuseppe Gibelli, Jonathan Rodrigues, E. Abdul Rahman, GJ. Fent, Ricardo Ladeiras-Lopes, Chrysanthos Grigoratos, Tomas Lapinskas, Paulius Bucius, Augustinas P. Fedaravicius, Laura Urbonaite, Agnieta Stabinskaite, Remigijus Zaliunas, Cannizzaro Maria Teresa, De Falco Alfano Daniele, Riccardo Righi, Michela Zerbini, Positano Vincenzo, Corrado Cittanti, Melchiore Giganti, Benea Giorgio, Dario Genovesi, Assuero Giorgetti, Sara Chiappino, Andrea Barison, Giuseppe Vergaro, Giancarlo Todiere, Michele Emdin, Paolo Marzullo, Henrique Turin-Moreira, Nuno Bettencourt, Ricardo Fontes-Carvalho, Francisco Sampaio, Bharath Ambale-Venkatesh, Colin Wu, Kiang Liu, Alain Bertoni, Pamela Ouyang, David Bluemke, João Lima, P. Garg, JF. Foley, P. Haaf, JP. Greenwood, S. Plein, PP. Swoboda, JR. Ismail, R. Najme Khir, CW. Lim, N. Chua, ZO. Ibrahim, HA. Zainal Abidin, MK. Mohd Arshad, SS. Kasim, Ben Rooms, Katie Hyde, Stephen Rohan, Mark Hamilton, Chiara Bucciarelli‐Ducci, Angus Nightingale, Julian Paton, Nathan Manghat, David MacIver, Walter Demolli, Alessandra Russo, Chiara Minoia, Salvatore Biasi, Christin Eltschkner, Meierhofer Christian, Peter Ewert, Stefan Martinoff, Heiko Stern, Claudio Fabbri, Roberto Mantovan, Stefano Severi, Cristiana Corsi, V. Vassiliou, M. Arzanauskaite, C. Izgi, W. Lam, S. Prasad, Sebastian Johannes Reinstadler, Gert Klug, Johannes Mair, Werner Jaschke, Wolfgang-Michael Franz, Bernhard Metzler, F. Muehlberg, S. Fritschi, S. Funk, M. Prothmann, F. von Knobelsdorff-Brenkenhoff, J. Schulz-Menger, B. Mohan, G A. karthik, Vimal Raj, Deirdre B Cassidy, Jill JF Belch, Stephen J Gandy, Graeme Houston, Matthew A Lambert, Roberta Littleford, Janice Rowland, Allan D Struthers, Faisel Khan, Marjorie Salel, Alexia Hennig, Olivier Corneloup, Michel Montaudon, François Laurent, Hubert Cochet, Bara Erhayiem, Adam K. McDiarmid, Pankaj Garg, Laura E. Dobson, Tarique A. Musa, David Ripley, Ramzi Ajjan, John P. Greenwood, Sven Plein, Peter P. Swoboda, Georg Fuernau, Charlotte Eitel, Suzanne de Waha, Steffen Desch, Gerhard Schuler, Holger Thiele, Ingo Eitel, A. Cadoni, C. D'andrea, S. Costa, P. Keilberg, A. Lunardini, GD. Aquaro, G. Peritore, F. Ricci, D. De Marchi, C. Passino, J. Navarro Cuartero, J.G. Córdoba Soriano, S. Calero Núñez, T. Cros Ruiz de Galarreta, M. Villar García, J.C. Gallego Page, J.C. García López, M. Barambio Ruiz, Jonathan C. Rodrigues, Bethannie McIntyre, Amy E. Burchell, Laura Ratcliffe, Emma C. Hart, Julian F. Paton, Angus K. Nightingale, Nathan E. Manghat, Takashi Tanimoto, Shingo Ota, Tsuyoshi Nishiguchi, Hiroto Tsujioka, Akio Kuroi, Takashi Yamano, Yoshiki Matsuo, Yasushi Ino, Hironori Kitabata, Takashi Kubo, Atsushi Tanaka, Takeshi Hozumi, Takashi Akasaka, Teresa Pinho, Paulo Canedo, Luís Lopes, Olga Azevedo, António Madureira, Adriana Belo, José Silva Cardoso, José Carlos Machado, Elisabete Martins, Andrzej Urbanik, Tomasz Rakowski, E. Pozo-Osinalde, D. Viliani, MJ. Olivera, P. Caballero, LJ. Jiménez-Borreguero, F. Alfonso, Giulia Angeloni, Angela Migliorini, Renato Valenti, Guido Parodi, David Antoniucci, Ana Galrinho, Luísa Moura-Branco, Nuno Tavares-Jalles, Marta António, João Abreu, Ana Teresa Timóteo, Pedro Pinto-Teixeira, Sílvia Aguiar-Rosa, Inês Rodrigues, Pedro Modas-Daniel, Rui Cruz-Ferreira, D. Dobre, S. Stanciu, E. Acatrinei, A. Nour, L. Stefan, P. Calistru, M. Pyda, M. Janus, A. Siniawski, Walid Abdel-Azim Elhammady, Mohamed Ismail Ahmed, Ahmed Samir Abdel-Hakim, Lamyaa Elsayed Allam, Ayman Mohamed Helal, Naokazu Mizuno, Gladys JUNCÀ, Javier ARCE, David ARMARIO, Damien Logeart, Barnabas Gelen, Genevie`ve Derumeaux, Eric Vicaut, Jean-Jacques Mercadier, Marc Sirol, Manuel De Lazzari, Angela Susana, Alessandro Zorzi, Anna Baritussio, Mariachiara Siciliano, Martina Marinato, Francesca Prevedello, Benedetta Giorgi, Roberto Vezzaro, Domenico Corrado, Martina Perazzolo Marra, K.-P. Rommel, J.T. Kowallick, S. Blazek, K. Fengler, J. Lotz, G. Hasenfuß, Ch. Lücke, M. Gutberlet, G. Schuler, A. Schuster, Ph. Lurz, Osama Rifaie, Ahmed Samir, Lamyaa Allam, Caroline Zotter-Tufaro, Stefan Aschauer, Diana Bonderman, Julia Mascherbauer, Arno A.W. Roest, Pieter J. van den Boogaard, Emmeline E. Calkoen, Rob J. van der Geest, Mark G. Hazekamp, Albert de Roos, Jos J.M. Westenberg, C.J. Kellenberger, J. Geiger, B. Ruecker, E.R. Valsangiacomo Buechel, J.R.J. Foley, G. Fent, T.A. Musa, L. Dobson, P.P. Swoboda, J.P. Greenwood, Amy Burchell, Laura Ratcliffe BSc(Hons), Emma Hart, Adrian Monserrat, Alicia Maceira gonzalez, Luis Tuset, Vicente Miro, Amparo Hernandiz, Rubén Fernandez, Asunción Sauri, Pilar Sepúlveda, Jose Luis Diez, Anastasio Montero, Massimo Imbriaco, Gianmarco Alcidi, Andrea Ponsiglione, Ciro Santoro, Marta Puglia, Luigi Barbuto, Alberto Cuocolo, Bruno Trimarco, Maurizio Galderisi, Elena Sanchez, Diego Plaza, Pilar Sepúlveda sanchis, Alicia Maceira Gonzalez, Alex vazquez, Luis Martinez, Hernandez Caballero Alfredo, Domingo Valero Diana, Maceira Gonzalez Alicia, Estornell Erill Jordi, Valera martinez Francisco Jose, Vazquez Sanchez Alejandro, Montero Argudo Anastasio, T.A. Shelkovnikova, S.V. Popov, P.I. Lukyanenok, A.A. Shelupanov, A.I. Oferkin, T.A. Bakhmet'eva, W.Yu. Ussov, Jos JM. Westenberg, Wikke Setz-Pels, Erik Kersten, Alexander Tielbeek, Lucien EM. Duijm, Johannes Post, Joep A.W. Teijink, A. Kirschfink, E. Mühler, N. Marx, H. Hövels-Gürich, Feistritzer Hans-Josef, Reinstadler Sebastian, Reindl Martin, Seidner Benjamin, Mayr Agnes, Müller Sylvana, Metzler Bernhard, aMamdouh Zidan, Ondrej Holub, Rachel Clough, Gerald Carr-White, Reza Razavi, Ralph Sinkus, E.E. Bobrikova, I.L. Bukhovets, M.P. Plotnikov, Yu.V. Rogovskaya, M.S. Rebenkova, W.Yu. Usov, Christian Kremser, Michael Schocke, F.R. Pluchinotta, G. Giusti, F. Secchi, L. Piazza, M. Carminati, M. Chessa, J.P. Bokma, B.J. Bouma, B.J. Mulder, M. Lombardi, Treibel Thomas, Kozor Rebecca, Bulluck Heeraj, Moon James, Manisty Charlotte, Fabienne Bertron, Sueheyla Oezkan, Dirk Lossnitzer, Stefan O. Schoenberg, Martin Borggrefe, Christina Doesch, NC. Edwards, B. Liu, MK. Hayer, CH. Dawson, T. Geberhiwot, RP. Steeds, H. Stern, N. Mkrtchyan, C. Meierhofer, S. Martinoff, P. Ewert, S. Fratz, Bruno Piçarra, Ana Rita Santos, Rui Guerreiro, Kisa Hyde Congo, João Carvalho, David Neves, José Aguiar, Kady Fischer, Chantal Labelle, Sylvie Gelineau, Sandra Farkas, Julie Lebel, Matthias G. Friedrich, Adriana Villa, Imane Bekri, Joy Shome, Tom Teall, Gabriella Di Giovine, Eva Sammut, Khaled Al-Fakih, Amedeo Chiribiri, Arno AW. Roest, Lucia JM. Kroft, Nico A. Blom, Mohammed SM. Elbaz, A. Soufiani, H. Barahioui, A. Bayi, N. Fellat, H. Benjelloun, Z. Tazi, A. Uddin, PP. Swoboa, CJ. Malkin, DJ. Blackman, Hiram G. Bezerra, Maria Rita Gamberini, Maria Giovanna Neri, Liana Cuccia, Domenico Giuseppe D'Ascola, Chiara Tudisca, Valentina Vinci, Vincenzo Positano, Alessia Pepe, Caterina Borgna-Pignatti, Giovanni Carlo Del Vecchio, Maria Antonietta Romeo, Federico Bonetti, Massimiliano Missere, Cristina Salvatori, TA. Fairbairn, OJ. Bebb, J. Foley, J. Eckert, M. Tröbs, A. Magedanz, M. Schmidt, T. Voigtländer, A. Schmermund, S. Achenbach, GF. Fent, J. Weir McCall, S.J. Gandy, W.G. Milne, J.G Houston, P. Ricchi, A. Spasiano, MG. Neri, A. Vallone, MC. Resta, R. Righi, V. Santamaria, V. Positano, A. Pepe, Tarek Bengrid, Rachel Nicoll, Ying Zhao, Bengt Johansson, Axel Schmermund, Irene Cascone, Eligio Miccichè, Sergio Buccheri, Sebastiano Immè, Gerlando Pilato, Claudia Tamburino, Martina Patanè, Simona Gulino, Denise Todaro, Tatiana Salerno, Valeria Garretto, Gianbattista Privitera, Davide Capodanno, Corrado Tamburino, Alessio La Manna, Pier-Giorgio Masci, Tobias Rutz, Jonathan De Blois, Juerg Schwitter, Pierre Monney, Tom Vandendriessche, Dina De Bock, Paul M. Parizel, Inez E. Rodrigus, Marc J. Claeys, F. Tosello, G. Bruno, E. Avenatti, R. Faletti, A Ravera, F. Veglio, A. Milan, A. Maggio, F. Leto, L. Pitrolo, A. Terrizzi, M. Serra, M. Allò, G. Di Bella, C. Zito, Neil J. Stewart, Charlotte Hammerton, David Capener, Valentina O Puntmann, Martin J. Graves, David G. Kiely, Jim M. Wild, Andrew J. Swift, A. Barison, N. Salvatore, P. Assennato, Beatrice A. Marzluf, Klaus Knechtelsdorfer, Matthias Wiesinger, Daniel Dalos, Stefan Pfaffenberger, Maciej Sosnowski, Zbigniew Gąsior, Ismail El-Hamamsy, François-Pierre Mongeon SM, Jan Eritsland, Limalanathan Shanmuganathan, Mikael Abdelnoor, Geir Øystein Andersen, Nils Einar Kløw, Pavel Hoffmann, Jérôme Caudron, Christophe Tron, Carlos Rodriguez Camacho, Alain Cribier, Jean Nicolas Dacher, Hélène Eltchaninoff, Geeta Gulati, Florian Von Knobelsdorff-Brenkenhoff, Tryggve Holck Storås, Jeanette Schulz-Menger, Torbjørn Omland, J. Traber, W. Utz, P. Hennig, M. Menza, B. Jung, A. Greiser, J. Kuijer, P. Barckow, A. Töpper, J Schulz-Menger, Sara Moscatelli, Luca Balzarini, Maria Pia Del Corral, Gabriele Gasparini, Orsola Montini, Lorenzo Monti, Alessandra Briatico, Patrizia Toia, Lamia Ait-Ali, Massimo Midiri, Antonio Raffaele Cotroneo, Pierluigi Festa, G. Todiere, C. Grigoratos, María Jose Sancho-Tello de Carranza, Alicia Maceira-Gonzalez, Francisco Buendía-Fuentes, Jordi Estornell-Erill, Oscar Cano-Perez, Jorge Sanz, Alicia Maceira, Ana Bel Minguez, Manuel Perez Guillen, Raquel Lopez, Alex Vazquez, Oscar rené, Pilar sepúlveda, Anastasio Montero argudo, Alisson Slimani, Mihaela Amzulescu, Christophe de Meester de Ravenstein, Agnès Pasquet, David Vancraeyenest, Jean-Louis Vanoverschelde, Bernhard Gerber, Anne-Catherine Pouleur, Stephen Lyen, Estefania De Gerate, Dudley Pennell, Chiara Bucciarelli-Ducci, Anna Kociemba, Justyna Rajewska-Tabor, Magdalena Janus, Andrzej Siniawski, Marek Stajgis, Małgorzata Pyda, Marta Brzostowicz, AD Villa, E Sammut, G Mullen, B Ganeshan, A Chiribir, Gerry P McCann, Boyang Su, Jiasheng Cai, Yiying Han, Ru San Tan, Stuart A Cook, Calvin WL Chin, E. Mara Vollema, Melissa Leung, Nina Ajmone Marsan, Jeroen J Bax, Victoria Delgado, E. De Garate, A. Ghosh Dastidar, N. Ahmed, A. Scatteia, J. Rodrigues, C. Lawton, Glyn Thomas, Edward Duncan, Tim Cripps, Ihab Diab, C. Bucciarelli-Ducci, M. Fontana, R. Kozor, R. Macrae, JW. Malcolmson, KD. Menacho, PR. Scully, DR. Lawrence, AM. Sheikh, AS. Herrey, C. Manisty, JC. Moon, C. Fernandez Golfin, JC. Portugal, A. Esteban, A. Megias, A. Gonzalez Gomez, LM. Rincon, JJ. Jimenez Nacher, JL. Zamorano, L. Gutierrez, G. Maldonado, V. Pineda, B. Agliano, L. Galian, G. Teixido, MT. Gonzalez-Allujas, A. Evangelista, D. Garcia-Dorado, JF. Rodriguez-Palomares, Kristina Belker, Susanne Naumann, Nerejda Shehu, Christian Meierhofer, Andreas Eicken, Alexander Weber, Sabrina Oebel, Gerhard Hindricks, Cosima Jahnke, Ingo Paetsch, AAW. Roest, PJ. van den Boogaard, NA. Blom, A. de Roos, JJM. Westenberg, Francesco Sturla, Selene Pirola, Emiliano Votta, Igor Nesteruk, Massimo Lombardi, Alessandro Della Corte, Malenka Bissell, Enrico Gianluca Caiani, Alberto Redaelli, MA Fernandez Mendez, A. García, G. Alonso, A. Marco, E. Casas, Francesca Pluchinotta, Amardeep Dastidar, Ben Littlejohns, Saadeh Suleiman, Andreas Baumbach, Vincenzo Vizzi, Yves Fierens, Jan Nijs, Johan De Mey, Peng Lai, Hubert Raeymaekers, Johannes Toger, Einar Heiberg, Jos J. Westenberg, Fatih Hafalir, Piero Ghedin, A. Shimakawa, C. Anja, Pedro Ferreira, Andrew D Scott, Sonia Nielles-Vallespin, Archontis Giannakidis, Philip J Kilner, Peter D Gatehouse, Ranil de Silva, David N Firmin, Dudley J Pennell, Hans-Wilko Beurich, Dirk Zachow, Mohamed El-Mawardy, Mohamed Abdel-Wahab, Gert Richardt, Ralph Tölg, Giovanni Biglino, Wilson Aileen, James Dodd, A. González Gómez, C. Fernández Golfín, A. Marco del Castillo, J. Monteagudo, M. Pascual Izco, A. Megías, A. García Martín, JJ. Jiménez Nacher, JL Zamorano, Alexander Carpenter, Alberto Palazzuoli, Catherine Wilson, Samantha Kestenbaum, Gergely Szantho, Chris Benny Lawton, Abhishek Shetye, Jamal N. Khan, Prathap Kanagala, Daniel Swarbrick, Gaurav Gulsin, Matthew Graham-Brown, Anthony Gershlick, and Gerry P. McCann

Subjects
Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine
Published
2016

26. Sulle tracce del cibo. Le analisi dei residui organici nelle ceramiche per la ricostruzione dei paesaggi della Puglia settentrionale tra Tardoantico e Medioevo

Author

M. T. Giannotta, FAVIA, PIETRO, D. Leone, M. Lettieri, F. Notarstefano, M. Turchiano, G. Volpe, G. Volpe, Giannotta, M. T., Favia, Pietro, Leone, D., Lettieri, M., Notarstefano, F., Turchiano, M., and Volpe, G.

Abstract

Nell'ambito di un progetto di ricerca sistematico sui paesaggi tardo antichi e medioevali del Nord della Puglia, sono state condotte analisi chimiche dei residui organici su 50 frammenti ceramici, provenienti dai siti archeologici di San Giusto, Faragola, San Giovanni in Canosa, San Lorenzo a Carmignano, Montecorvino. Le indagini chimiche hanno contribuito in modo significativo a raccogliere nuove informazioni sui contenuti delle ceramiche, rivelando dati precedentemente sconosciuti per la ricostruzione delle abitudini alimentari e suggerendo nuove prospettive attraverso il confronto con i risultati degli studi archeobotanici e archeozoologici negli stessi siti.

Published
2018

27. Iterative optimisation of Monte Carlo detector models using measurements and simulations

Author

D. Leone and O. Marzocchi

Subjects
Physics, Set (abstract data type), Nuclear and High Energy Physics, Iterative method, Detector, Monte Carlo method, Dynamic Monte Carlo method, System of linear equations, Instrumentation, Algorithm, Particle detector, Linear equation
Abstract

This work proposes a new technique to optimise the Monte Carlo models of radiation detectors, offering the advantage of a significantly lower user effort and therefore an improved work efficiency compared to the prior techniques. The method consists of four steps, two of which are iterative and suitable for automation using scripting languages. The four steps consist in the acquisition in the laboratory of measurement data to be used as reference; the modification of a previously available detector model; the simulation of a tentative model of the detector to obtain the coefficients of a set of linear equations; the solution of the system of equations and the update of the detector model. Steps three and four can be repeated for more accurate results. This method avoids the “try and fail” approach typical of the prior techniques.

Published
2015

28. Measurement of the absolute branching ratio of the K+→π+π−π+(γ) decay with the KLOE detector

Author

C. Bacci, F. Crucianelli, S. Giovannella, G. De Zorzi, P. Ciambrone, P. Massarotti, Barbara Sciascia, M. Martini, G. Venanzoni, G. Lanfranchi, F. Ambrosino, P. Valente, S. Chi, P. Franzini, M. Palutan, M. L. Ferrer, W. Mei, S. Miscetti, F. Perfetto, T. Capussela, F. Ceradini, B. Di Micco, G. Bencivenni, R. Versaci, G. Saracino, Massimo Antonelli, J. Lee-Franzini, S. Meola, F. Nguyen, Alessandra Doria, C. Forti, G. Xu, F. Cesario, C. Bloise, Claudio Gatti, A. Antonelli, Margherita Primavera, A. Di Domenico, Francesco Lacava, F. Bossi, F. Archilli, A.L. Sibidanov, M. Napolitano, M. Testa, D. Leone, L. Tortora, T. Spadaro, A. Passeri, S. Fiore, Edoardo Gorini, P. De Simone, E. Graziani, G. Felici, P. Branchini, M. Dreucci, Vincenzo Patera, Enrico Pasqualucci, V. V. Kulikov, Cesare Bini, W. Kluge, A. Sciubba, M. Moulson, A. De Santis, E. De Lucia, Pierluigi Campana, F. Murtas, S. Müller, S. Bertolucci, A. Denig, P. Gauzzi, M. Martemianov, Simona Serena Bocchetta, G. Chiefari, C. Di Donato, P. Santangelo, G. Capon, P. Beltrame, and Andrea Ferrari

Subjects
Nuclear physics, Physics, Nuclear and High Energy Physics, Particle physics, Meson, Branching fraction, Electron–positron annihilation, Detector, Pi, Physics::Accelerator Physics, High Energy Physics::Experiment, Radiation
Abstract

The absolute branching ratio of the K+ -> pi(+) pi(-) pi(+) (gamma) decay, inclusive of final-state radiation, has been measured using similar to 17 million tagged K+ mesons collected with the KLOE detector at DA Phi NE, the Frascati phi-factory. The result is: BR(K+ -> pi(+) pi(-) pi(+) (gamma)) = 0.05565 +/- 0.00031(stat) +/- 0.00025(syst) a factor similar or equal to 5 more precise with respect to the previous result. This work completes the program of precision measurements of the dominant kaon branching ratios at KLOE.

Published
2014

29. Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

Author

Jonathon Kaiser, Peter J. O'Dwyer, Angela DeMichele, Andrea B. Troxel, Leslie A. Fecher, Yunyoung C. Chang, Maryann Gallagher, Amy Kramer, Lynn M. Schuchter, Kay See Tan, Robert D. Leone, Lisa E. Davis, Laura Pontiggia, Shengfu Piao, Ravi K. Amaravadi, Tracey L. Evans, Daniel F. Heitjan, Reshma Rangwala, Katherine L. Nathanson, and Glenda Rodgers

Subjects
Adult, Male, autophagy, medicine.medical_specialty, hydroxychloroquine, Nausea, medicine.medical_treatment, Pharmacology, Biology, chemotherapy, Gastroenterology, Pharmacokinetics, Refractory, Neoplasms, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Temozolomide, melanoma, medicine, Humans, Molecular Biology, Aged, Neoplasm Staging, Aged, 80 and over, Chemotherapy, Dose-Response Relationship, Drug, Melanoma, clinical trial, Hydroxychloroquine, Cell Biology, Middle Aged, medicine.disease, 3. Good health, Dacarbazine, Treatment Outcome, Pharmacodynamics, Female, Clinical Research Paper, medicine.symptom, medicine.drug
Abstract

Blocking autophagy with hydroxychloroquine (HCQ) augments cell death associated with alkylating chemotherapy in preclinical models. This phase I study evaluated the maximum tolerated dose (MTD), safety, preliminary activity, pharmacokinetics, and pharmacodynamics of HCQ in combination with dose-intense temozolomide (TMZ) in patients with advanced solid malignancies. Forty patients (73% metastatic melanoma) were treated with oral HCQ 200 to 1200 mg daily with dose-intense oral TMZ 150 mg/m (2) daily for 7/14 d. This combination was well tolerated with no recurrent dose-limiting toxicities observed. An MTD was not reached for HCQ and the recommended phase II dose was HCQ 600 mg twice daily combined with dose-intense TMZ. Common toxicities included grade 2 fatigue (55%), anorexia (28%), nausea (48%), constipation (20%), and diarrhea (20%). Partial responses and stable disease were observed in 3/22 (14%) and 6/22 (27%) patients with metastatic melanoma. In the final dose cohort 2/6 patients with refractory BRAF wild-type melanoma had a near complete response, and prolonged stable disease, respectively. A significant accumulation in autophagic vacuoles (AV) in peripheral blood mononuclear cells was observed in response to combined therapy. Population pharmacokinetics (PK) modeling, individual PK simulations, and PK-pharmacodynamics (PD) analysis identified a threshold HCQ peak concentration that predicts therapy-associated AV accumulation. This study indicates that the combination of high-dose HCQ and dose-intense TMZ is safe and tolerable, and is associated with autophagy modulation in patients. Prolonged stable disease and responses suggest antitumor activity in melanoma patients, warranting further studies of this combination, or combinations of more potent autophagy inhibitors and chemotherapy in melanoma.

Published
2014

30. Poster session Wednesday 11 December all day display: 11/12/2013, 09:30-16:00 * Location: Poster area

Author

S. Bosi, K. Wierzbowska-Drabik, W. Mullens, C. Goh, M. Abdel Ghany, J. Monmeneu, M. Perez Guillen, B. Zaborska, A. Di Lenarda, H. Mueller, M. Dluzniewski, R. Del Pozo Contreras, E. Laraudogoitia Zaldumbide, S. Yurdakul, O. Bech-Hanssen, M. Fernandez Garcia, R. Ippolito, C. Torromeo, B. Popescu, M. Cameli, P. Gaudron, M. Salvetti, R. Amano, E. Osto, P. Cabeza Lainez, G. Generati, C.H. Attenhofer Jost, J. Rueda-Soriano, F. Negri, T. Zielinski, M. El Serafi, Y. Agmon, I. Losano, Y. Qin, I. Castiglione, G. Santambrogio, A. Farhati, P. Menasche, K. Wdowiak-Okrojek, R. Juneja, G. Di Sciascio, N. Gaibazzi, D. Shin, F. Romeo, O. Huttin, P. Puddu, I. Ikonomidis, T. Baran, G. Tinica, A. Bel Minguez, E. Erdogan, M. Herruzo Rojas, I. Ter Horst, J. Suarez De Lezo, P. Bertrand, B. Putnikovic, O. Kretschmar, M. Gigli, F. Scholz, M. Lainscak, O. Rifaie, E. Tahirovic, A. Svanadze, G. Makavos, L. Iliuta, L. G. T. Zacharias, M. Baldelli, A. Porto, C. Di Nora, O. Asghar, A. Ramalli, W. Krol, M. Ahmed Abdel-Rahman, R. Autschbach, R. Tripodi, A. Budaj, V. Velagic, J. Kurcz, J. Aguilar, V. V. Kochmasheva, O. Enescu, H. Triantafyllidi, J. Diago, J. Park, J. Breur, F. Tona, M. Cikes, C. Maurea, T. Edvardsen, B. Igual Munoz, B. Michalski, J. Separovic Hanzevacki, A. Hagege, L. Gullestad, P. Sogaard, T. Fritz-Hansen, M. Rosca, A. Kuch-Wocial, C. Gonzalez Canovas, H. Uyarel, M. Guazzi, E. Pigatto, M. Carminati, R. Soyka, P. Tortoli, D. Djordjevic-Radojkovic, D. De Palma, L. Yuan, E. Mazzotta, M. Henein, D. Botezatu, J. Feng, L. Casteilla, C. Vignati, I. Burazor, M. Krestjyaninov, E. Zhdanova, D. Milicic, H. Mahfoudhi, A. Aziz, P. Trivilou, R. Hoffmann, A. Mysiak, C. Martini, K. Haugaa, F J V M Francisco Jose Valera Martinez, J. Lessick, M. Maccherini, C. Olympios, D. Mutlak, B. Haugen, M. Martin, A. Santoro, A. Orda, B. Skoric, S. Mihaila, M. Jung, G. Leenders, A. Bozkurt, M. Greco, M. Muratori, A. Subinas Elorriaga, Z. Radunovic, A. Osa-Saez, Z. Suciu, M. Alloni, F. Alamanni, J. Choi, J. Schwartz, M. Mericskay, M. Gurzun, D. Leone, P. Omede, J. Sawicki, D. Saura Espin, E. W. Remme, M. Bando, M. Varoudi, J. Gonzalez Carrillo, G. F. Gjerdalen, S. Aakhus, T. Bombardini, F. Veglio, L. Baduena, A. Calin, B. Austin, C. Viacroze, S. Aytekin, C. Santoro, I. Benedek, S. Comenale Pinto, F. Verbrugge, G. Styczynski, M. Sunbul, N. Pandian, T. Forster, J. Hisdal, S. Mondillo, M. Mourali, L. Magda, A. Quesada-Carmona, E. Caiani, G. Pavlidis, S. Ojeda, W. Ding, S. Ramakrishnan, L. Stefanczyk, A. Voumbourakis, A. M. Maceira Gonzalez, B. Igual, C. Selton-Suty, O. B. Kerbikov, B. Karolko, P. Lipiec, F. Meijboom, T. Andersen, M. Pellegrino, M. Lopez-Lereu, J. Kasprzak, Y. Zhao, R. Lang, M. Valdés Chávarri, J. Muir, A. Goetzenich, J. Hooper, M. Driessen, M. Greutmann, S. Casablanca, V. Curci, P. Szymanski, M. Cramer, F. Tosello, C. Gronlund, M. Chiavarelli, A. Cuvelier, P. Mogutova, F. Bandera, G. Greil, P. Fernandez Garcia, E.R. Valsangiacomo Buechel, M. Sobczynska, M. Kennedy, S. Boitard, D. Voilliot, H. Bellsham-Revell, A. Casacalenda, M. Sata, P. J. Sanchez Millan, S. Nishio, C. Chrisochoou, S. Mirfeizi, C. Beladan, K. Steine, M. Lisi, N. Krylova, A. Vlahovic-Stipac, S. Carerj, A. Oxenius, B. Geloneze, R. Calabro, E. Occhetta, P. Caso, R. Massey, B. Cengiz, M. Palencia-Perez, X. Xu, S. Brili, A. Evangelista, D. Mesa, S. Abadi, V. Reskovic Luksic, G. De La Morena Valenzuela, M. Anzini, S. Iliceto, A. Saxena, D. Vinereanu, G. Ussia, M. Sikora-Frac, S. Censi, R. Razavi, T. Wakatsuki, M. Romero, L. Punzi, C. Stefanadis, M. Pepi, E. Chueca Gonzalez, D. Rea, R. Chistol, I. Michalowska, N. Hayes, J. D'hoge, H. Aloui, D. Verhaert, I. Lekuona Goya, O. Sklyanna, K. Taamallah, S. Urheim, B. Natali, G. Sieswerda, M. Casartelli, D. Czarnecka, K. Lagerstrand, T. Chamova, E. Solberg, L. Sabia, M. Vatankulu, M. Obremska, D. Stolfo, H. Haouala, G. Bajraktari, G. Oria Gonzalez, I. Tournev, N. Olsen, O. R. Coelho, F. Spano, J. Yip, M. Anastasiou-Nana, A. Montero Argudo, S. Poli, J.-M. Sellal, P. Kulakowski, K. Kawecka-Jaszcz, O. Sonmez, M. Merlo, A. Chiru, A. Moreo, A. Colombo, R. Dahmani, W. Fehri, V. Rameev, D. Liu, A. Olszanecka, G. Placha, N. Kouris, A. Zaroui, J. Ljubas, G. Famoso, A. Massoni, S. Gao, M. Delgado, I Rodriguez Sanchez, R. Vazquez Garcia, D. Peluso, V. Planat-Benard, J. Cosin-Sales, E. Avenatti, V. Karidas, G. Sinagra, B. Jako, E. Alfonzetti, C. Hernandez Acuna, H. Farouk, D. Foley, M. Chmiela, P. Gripari, G. Patti, J. C. Pareja, Y. Hwang, C. Polte, D. Damaskos, D. Aronson, T. Rechcinski, T. Soeki, D. Simon, D. Anderson, N. Maurea, A. Brunet, C. Florescu, M. Marchei, A. Safarova, F. Cozzi, A. Neskovic, S. Mega, V. Miro-Palau, K. Darahim, B. Bednarz, A. Bitto, F. De Stefano, E. Kostarska-Srokosz, A. Nemes, G. Vizzari, T. Leiner, N. E. Hasselberg, P. Maffei, F. Mezni, Z. Bogdanovic, S. Kul, W. Kosmala, M. Rivero-Ayerza, G. Piscopo, M. Schiariti, V. Cammalleri, V. Kostopoulos, S. Storve, S. Stoerk, I. Planinc, B. Mutlu, J. R. M. Souza, J. J. Onaindia Gandarias, V. Donghi, H. Hamdi, G. Bagadur, A. Mabrouk Salem Omar, M. Floria, A. Klisiewicz, G. Barbati, A. Akhundova, A. Cacicedo, M. Annabi, D. Domingo-Valero, J. Simpson, J. Suarez De Lezo Herreros De Tejada, F. Cesana, D. Sergi, G. Alongi, M. Coppola, L. Grieten, G. Woo, L. Badano, G. Ertl, L. Caballero Jimenez, E. Donal, A. Kalapos, A. Anna Klisiewicz, H. Duengen, F. Mazuelos, U. Aguirre Larracoechea, N. Hasselberg, P. Domsik, L. Fusini, Z. Rezine, M. Misailidou, M. Rodriguez Serrano, D. Waterhouse, K. Keramida, F. Procaccio, G. Dell'era, N. Popova, F. Musumeci, D. Presutti, S F de Marchi, J. Van 'T Sant, S. Moisseyev, K. Paraskevopoulos, L. Molano, J. Estornell Erill, M. Gaspari, Z. Kobalava, I. Jedrzejewska, M. Galderisi, S. Neubauer, Piotr Hoffman, U. Cucchini, O. Miller, W. Kong, A. Swiatowiec, M. Vrolix, C. Grattoni, K. Broch, P. Ibrahimi, M. Garcia Navarro, R. Sheahan, P. Hoffman, M. Boratynska, J. Castillo Ortiz, R. Jankovic-Tomasevic, S. Wijers, P. Lindqvist, C. Tiu, V De Francesco, C. Goffredo, P. Agostoni, H. Yamada, V. Varano, T. Al-Maimoony, P. Wester, P. Schoof, J. Son, P. Piotr Szymanski, F. Righini, O. Agbulut, P. Nardinocchi, A. Aljalloud, I. Stankovic, O. A. Smiseth, L. Halmai, A. Bacaksiz, S. Rayasamudra, D. Filipiak, D. Muraru, D. Zysko, S. Muscoli, O. Goktekin, M. Przewlocka-Kosmala, S. Ryu, Z. Baricevic, M. Meine, J. Monmeneu Menadas, L. Gheorghe, A. Cremonesi, M. Lipczynska, A. Chaim, M. K. Smedsrud, M.D. Espinosa García, S. Mbarki, I. Stamatopoulos, L. Ling, F. Jashari, Y. Juilliere, D. Lahidheb, B. Mcadam, B. Bijnens, B. Pezo Nikolic, V. Guergueltcheva, J.-P. Vallee, O. Erdogan, R. Muscariiello, R. Mincu, M. Deljanin Ilic, C. Coppola, F. Arenga, J. Walker, M. Bono, J. Segura, R. Mechmeche, H. Uppal, S. Hayashi, A. Alhadad, M. Klinger, S. Herrmann, S. Snare, J. Estornell, M. Grecu, L. Lukasz Mazurkiewicz, J. Hotchi, C. Cipresso, E. Esposito, T. Marwick, N. Poteshkina, C. Zito, A. Squeri, V. Razin, I. Paraskevaidis, M. Jemaa, R. Marcun, R. Potluri, A. Anton Ladislao, F. Buendia-Fuentes, M. Pavlovic, S. Salinger-Martinovic, B. Igual-Munoz, T. Seoane, K. Mischke, G. Tamborini, G. Kim, A. Kardos, G. Pizzino, C. Matei, N. Hatam, V. P. Dityatev, H. Torp, A. Degiovanni, F. Rigo, M. Janulewicz, M. Gospodinova, M. Pan, P. Vallerio, F. Gaita, X. Jin, M. Akkaya, B. Pinamonti, A. Javanbakht, B. Lamia, N. A. Yaroshchuk, L. Musial-Bright, W. J. Nadruz, I. Papadakis, G. Kunszt, Y. Hirata, A. Shim, P. Maciejewski, M. Oliva Sandoval, S. Kadivec, E. Pilichowska-Paszkiet, F. Ranocchi, H. Neametalla, K. Hu, I. Sari, F. Carrasco, R. Ancona, R. Weber, R. Ivanova, A. Bartorelli, K. Eskesen, L. Teresi, P. Lopez Lereu, A. Holmgren, M. Kosnik, M. Turfan, M. Sobieszczanska-Malek, E. Kongsgaard, A. Bell, G. Hong, S. Denchev, A. Tasal, D. Mihalcea, F. Weidemann, G. De Caridi, A. Haggui, N. Hajlaoui, P. Alonso-Fernandez, A. Quattrone, M. Massetti, W. Braksator, I. Lekakis, T. Sahin, S. Carasso, F. Dassie, C. Bucca, C. Ginghina, C. A. Szmigielski, J. Baran, Z. Li, E. Aliot, A. Milan, J. Farkas, C. Smeets, D. Stanojevic, H. Dalen, S. Apostolovic, C. Moretti, G. Bruno, X. Zhao, E. Christoforatou, C. Arra, H. Poorzand, J. Ruvira, R. Matasic, F. Maffessanti, T. Vaugrenard, E. Szymczyk, R. Gimaev, S. Tellatin, C. Magnino, S. Velasco Del Castillo, P. Vandervoort, P. Doevendans, A. Dragan, M. Florescu, D. Carballo, P. Marino, D. Lovric, J. Nilson, L. Tong, H. Khorshid, R. Enache, A. Ruck, T. Benedek, R. Winter, M. Ruiz Ortiz, and E. Johansson

Subjects
medicine.medical_specialty, business.industry, medicine, Radiology, Nuclear Medicine and imaging, Medical physics, General Medicine, Session (computer science), Cardiology and Cardiovascular Medicine, business
Published
2013

31. Measuring the Pion From Factor via Radiative Return at large photon angles with KLOE

Author

D. Leone, KLOE Collaboration, GORINI, Edoardo, PRIMAVERA, Margherita, VENTURA, Andrea, D., Leone, Gorini, Edoardo, Primavera, Margherita, Ventura, Andrea, and Kloe, Collaboration

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Muon, Photon, Nuclear Theory, Hadron, KLOE Pion form factor, Atomic and Molecular Physics, and Optics, law.invention, Nuclear physics, Cross section (physics), Pion, law, Radiative transfer, Physics::Accelerator Physics, High Energy Physics::Experiment, Invariant mass, Nuclear Experiment, Collider
Abstract

The KLOE experiment at the electron-positron collider DAΦNE uses the radiative return to measure the hadronic cross section σ ( e + e − → π + π − ) . The energy of DAΦNE is fixed at s = M Φ = 1020 MeV , but the emission of one (or more) photons in the initial state (ISR) reduces the collision energy, allowing to cover the two-pion invariant mass M π π in the region from the two pion threshold to m ϕ . The precise measurement of this cross section is used to calculate the hadronic contribution to the muon anomaly a μ . A first measurement, in which the ISR-photon is detected at small polar angles, has already been performed at KLOE. Here we present the status of a complementary analysis at large photon polar angles. This allows to extend the measurement of the two-pion cross section to low masses below 600 MeV.

Published
2006

32. MODERATED POSTER SESSION: Diseases impact on left ventricular function: Friday 5 December 2014, 08:30-18:00 * Location: Moderated Poster area

Author

J. Ternacle, G. Pedrizzetti, M. Maciel, M. Trivigno, S.O Rosillo Rodriguez, A. Milan, A. Ravera, T. Lopez Fernandez, A. Guellich, L. Hittinger, I. Ponz De Antonio, D. Bodez, J. Silva-Cardoso, Z. Friedman, J. Rodrigues, I. Rangel, F. Cicogna, F. Macedo, A. Kremzer, J.-L. Dubois-Rande, M. De Buyzere, D. Projevska-Donegati, E. Zemtsovsky, M. Omelchenko, E. Avenatti, V. Milazzo, Payman Zamani, D. Leone, D. Cantisani, V. Plante-Bordeneuve, C.-M. Tissot, P. Almeida, Dirk De Bacquer, F. Veglio, Thierry C. Gillebert, N. Smirin, Z. Blazquez Bermejo, S. Shimoni, J.-F. Deux, L. Sabia, A. Goncalves, Ernst Rietzschel, S. Rappeneau, Prithvi Shiva-Kumar, M. Moreno Yanguela, T. Damy, L. Georgievska-Ismail, S. Cimino, R. Mori Junco, T. Berezina, Julio A. Chirinos, C. Sousa, L. Agati, A. Fabbri, D. Adam, J Caro Codon, A. Hagendorff, Z. Hristovski, Tom Claessens, Patrick Segers, L. Vasina, G. Tonti, Scott Akers, J. Lopez-Sendon, E. Malev, F. Tosello, C. Caira, D. Gemma, T. Samura, G. Bruno, A. Berezin, H. Khamis, and S. Valbuena

Subjects
medicine.medical_specialty, Ventricular function, business.industry, Physical therapy, medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Session (computer science), Cardiology and Cardiovascular Medicine, business
Published
2014

33. 'Interrogating Fallacies, Stereotypes and Denigrations of Africa in Eurocentric Discourse'

Author

Ovie-D ' Leone and Alex Igho

Subjects
Underdevelopment, Geography, Paradise lost, Annals, medicine, Ethnology, medicine.symptom, Collapse (medical), Genealogy
Abstract

Africa is one continent that has suffered some of the worst forms of physical and psychological bashing in the hands of European explorers, Colonists and historians alike. Compared to other locations in the world, the rich annals of the continent have also been seemingly twisted out of rhythm with the intent to justify long years of exploitations and stereotyping of the people and their cultures cast in the imageries of barbarians and cannibals. Such a ‘paradise lost’ is also presented as a social abnormality that defies any form of redemption. This paper interrogates the logic of such bland Eurocentric misconceptions/stereotypes with a view to highlighting how such skewed imageries invariably have contributed adversely to the ‘development of underdevelopment’ across Africa over the years. The paper concludes that, there is now a dire need for the European interlopers to genuinely begin to partner with Africans with a view to correcting such skewed imageries that have thus far brought Africa to the precipice of imminent systemic collapse.

Published
2013

34. Autophagy: a targetable linchpin of cancer cell metabolism

Author

Robert D. Leone and Ravi K. Amaravadi

Subjects
Programmed cell death, Mechanism (biology), Endocrinology, Diabetes and Metabolism, Autophagy, Metabolism, Biology, Article, Cell biology, Endocrinology, Downregulation and upregulation, Neoplasms, Organelle, Cancer cell, Animals, Humans, Intracellular
Abstract

Cancer cells display several features of aberrant cellular metabolism. Two consequences of this dysregulated metabolism are rapid depletion of intracellular nutrients and a buildup of aggregated proteins and damaged organelles. Autophagy provides a mechanism for recycling proteins, lipids, and organelles. In cancer cells, oncogenes and conditions of severe stress drive profound upregulation of autophagy. In this setting, autophagy ameliorates the ill effects of dysregulated cellular metabolism, allowing a steady supply of nutrients and removal of damaged organelles. Although therapeutic strategies targeting cancer cell metabolism and autophagy are already entering clinical trials, further study of the precise mechanisms of interplay between oncogenic signaling, cellular metabolism, and autophagy will provide more effective strategies in the future.

Published
2013

35. Poster session: Dobutamine stress echo

Author

C. Vizza, X. Jeanrenaud, M. Satendra, L. Monti, A. Kovacs, D. Vanoli, V. Charles, A. Kardos, M. Chiarlo, C. Gruner, C. Monaco, A. Kuch-Wocial, K. Mizia-Stec, L. Sargento, D. Kautznerova, N. Resseguier, G. Tamborini, C. Cruz, P. Jurzak, A. Cogo, E. Lira, D. Al Mesned, Y. Aizawa, A. Chmiel, R. Corti, K. Kim, G. N. Elkilany, M. Haarman, R. Badagliacca, R. Weber, R. Bruno, L. Di Pino, I. Kaplanis, D. Kalimanovska-Ostric, D. Tsounis, M. Varoudi, H. Yoon, P. Goncalves, G. Mpitsios, I. Garcia-Lunar, P. Min, R. Mogelvang, K. Gieszczyk-Strozik, A. Blundo, A. Tarr, E. W. Remme, David Garcia-Dorado, V. Petronilli, A. Patel, C. Sousa, R. M. Lang, J. Mcghie, V. Monivas Palomero, C. Nomura, H. Yoshikawa, N. Lagopati, M. Gomberg-Maitland, R. Kalil, H. K. Jeon, K. Mrabet, A. Riberi, C. Zito, A. Khalatbari, D. Tarasov, L. Fusini, P. Marques, S. Hassantash, I. Zimbarra Cabrita, M. Francone, A. Germain, A. Theron, J. Sousa, A. Kantorova, F. Collart, C. J. Vrints, A. Forteza, C. Tamburino, D. Cerna, S. Buccheri, M. Taborsky, I. P. Monte, F. Elmkies, A. Castro Beiras, S. Ranjbar, A. Perpinia, O. A. Tolba, R. Pretre, T. Chua, F. Fedele, M. Calcagnino, D. Dragulescu, M. Greutmann, M. Pepi, M. Bartesaghi, S. Urheim, R. Muscariello, F. Ben Moussa, W. Saib, M. Thameur, J. Ternacle, V. Matzraki, M. Ghannouchi, G. Kocabay, A. Margulescu, R. Sicari, R. Ippolito, M. Kloeckner, A. Toth, J. Gonzalez Mirelis, K. Sugi, M. Geleijnse, T. Otsuka, A. Hervold, S. Benyoussef, B. Basnyat, H. Suomi, L. Gargani, M. Stosic, P. Monney, J. Segovia Cubero, M. Karvandi, P. Sousa, J. Gonzalez-Mirelis, P. Caso, M. Murata, M. Vieira, C. Fulcheri, M. Júlia Maciel, P. Garcia-Pavia, M. Bobbo, J. Sun, B. Nardi, V. Pyrgakis, J. W. Kim, F. Alamanni, D. Ozel, A. Cordovil, S. Cimino, S. Papa, A. Carro, E. Leiballi, S. Karakas, J. Cho, C. Mornos, H. Masai, M. D'angelo, S. Mingo Santos, J. Kang, N. Nishiyama, J. Brugada, W. Tsang, Y. Yoon, B. Herzog, F. Dominguez Rodriguez, G. Ertl, E.R. Valsangiacomo Buechel, H. Shin, M. Palinsky, P. Gaudron, O. Gaemperli, A. Bouzas Mosquera, R. Bogle, J. Rodriguez-Palomares, N. Liel-Cohen, J. Burrello, M. Henein, H. Yilmaz, M. Laine, C. Foucher, K. Tanimoto, P. Schiattarella, G. Teixido, V. Schiano Lomoriello, M. R. El-Shanshory, N. Lousada, T. Minarik, F. Machado, G. Hashimoto, Y. Ishikawa, P. Atkinson, I. Zairi, B. Lee, V. Lanska, T. Biering-Sorensen, D. Vinereanu, H. Dores, M. Nakamura, R. Kockova, A. Chenzbraun, A. Manrique, N. A. Garcia, C. Zimmermann, L. Carpinteiro, H. Youn, J. Guimaraes, P. Meimoun, M. Mohammed, A. Gaspar, G. Styczynski, M. Castella, R. Esposito, A. Karavidas, F. Tosello, J. Mills, J. E. Sanderson, Y. Lau, D. Lee, C. Chin, M. Dostanic, D. Liu, P. Lupinek, T. Sato, M. Lewis, M. Reali, E. Cervesato, A. Apor, D. Sharif, S. Leggio, T. Ono, S. Wos, S. Kadrabulatova, S. Miyoshi, B. Milakovic, M. Gonzalez-Alujas, Y. Y. Lam, W. Tietge, M. Tramarin, L. Balzarini, E.-S. El-Hawary, G. E. Nagib Elkilany, P. Lim, P. Lindqvist, F. Veronesi, G. Flahaut, M. Thomas, A. Redheuil, Y. Ahn, M. Galderisi, M. Cavero Gibanel, J. Roquette, G. D. Lenders, F. Cicogna, P. Nihoyannopoulos, S. Taddei, C. Shahla, O. Mirea, A. Aleixo, E. Altekin, A. Milan, J. Roncalli, V. Mor-Avi, P. Crapanzano, S. Wang, A. Rodrigues, D. De Palma, M. Sitges, J. Peteiro, G. Maldonado, A. Nagy, J. Wang, M. Miglioranza, M. J. Claeys, J. Kluin, R. H. Strasser, J. Masura, B. Pezzuto, S. Aakhus, M C De Knegt, F. Broullon, N. Bhave, Y. Kusunose, R. Domburg, S. Moral Torres, J. Song, G. Carlomagno, P. Carrilho-Ferreira, A. Mornos, K. Sedlacek, Y. Villain, S. Arapi, M. Segetova, T. Le Tourneau, M. Kucuk, H. Tsuruta, J.-L. Monin, L. Badano, C. Mueller, C. Jorge, J. Kautzner, U. Schubert, L. Zhong, B. Suran, J. Clerc, I. Demir, S. Chamuleau, P. Tittel, E. Boussabah, P. Punjabi, L. Guimaraes, C. Magnino, B. Delasalle, D. Leone, J. Gruenenfelder, H. Blafield, F. Thuny, J. Jensen, J. Silva Cardoso, S. Stoebe, S. Sioua, K. Fukuda, M. Nocioni, P. Linden, V. Sanchez, D. Silva, V. Sikula, F. Pizzino, L. Kryze, A. Lebreiro, M. Deljanin-Ilic, A. Arsenio, S. Takatsuki, M. Kaldararova, A. Sikora-Puz, M. Cinello, S. Naffati, M. Pirscova, V. Lisignoli, A. Hagendorff, T. Iwaki, M. Niemann, E. Rees, U. Rosenschein, V. Vrsanska, C. A. Szmigielski, G. L. Nicolosi, G. Di Bella, D. Pfeiffer, R. Giorgi, K. Korpi, E. Paucca, M. Sanchez Garcia, S. Kammoun, M. Rodolico, Arturo Evangelista, I. Baka, J. Lima, C. Yu, B. Hong, C. Fischer, P. Morera, F. C. Tanner, R. Manganaro, M. Mezzapesa, B. Seifert, A. Berruezo, H. Guterman, K. Sveric, U. Wiklund, R. Sant'anna, R. Piazza, L. Oreto, L. Mont, J. Rosso, B. P. Paelinck, S. Severino, J. Park, S. Morhy, S. Mingo, A. Ledakowicz-Polak, L. Arcari, E. E.-S. El-Hawary, E. Caiani, R. Fabregas Casal, A. Bensaid, N. A. E.-A. El-Shitany, F. Veglio, L. Gutierrez, R. Massey, R. Mimo, A. Yanikoglu, A. Al Akhfash, J. Rodriguez Garrido, S. Kovalova, N. Patrascu, M. Liu, B. Bijnens, J.-L. Dubois-Rande, M. Suzuki, I. Garcia Lunar, D. Muraru, S. Iwanaga, R. Borras, R. Karpov, T. Nastasovic, T. Gonzalez-Alujas, M. Jasinski, H. Marques, W. Voelker, D. Maan Hasson, K. Murbrach, J. Yoon, M. Cusma-Piccione, S. Carerj, E. Hopp, D. A. Rees, M. Zielinska, M. Forkmann, M. Sotiropoulos, I. Zegri, Y. Neuder, V. Hraska, R. Iengo, I. Losano, P. Gripari, J. Avierinos, I. Simkova, M. Yaacobi, F. Weidemann, C. Sordelli, H. Jeong, T. Osaki, M. Kubanek, R. Sharma, M. Yamamoto, D. Bettex, J. Sivertsen, G. Bruno, A E Van Den Bosch, P. Kracht, P. L. Van Herck, J. Roos-Hesselink, D. Cozma, E. Teiger, L. Said, B. Freed, A. Loimaala, T. Pinho, L. Pomidori, A. Mantovani, A. Santoro, R. Kadour, R. Calabro, S. Rim, L. Sim, B. Merkely, P. Gueret, R. Jansen, G. Curatolo, C.H. Attenhofer Jost, C. Gambardella, V. Jarvinen, P. Hol, D. Mihalcea, P. Sogaard, D. Peluso, O. Kretschmar, F. Fang, H. Cuellar, F. Maffessanti, R Palma Dos Reis, J. Grapsa, A. Sharif-Rasslan, H. Kwon, P. Novak, R. Gallet, C. Sportouch, O. Enescu, H. Chung, M. Valtonen, D. Dawson, A. G. Fraser, M. Lyra Georgosopoulou, Q. Shang, V. Leonelli, L. Agati, A. Khalil, G. Habib, M. Cavero, A. Ionac, M. Florescu, S. Pescariu, L. Ascione, M. Carmo, A. Marouen, A. D'Andrea, S. Champagne, S. Iliceto, J. P. Halcox, M. Mizia, Z. Gasior, M. Cramer, S F de Marchi, S. Goncalves, L. Dal Bianco, N. Cortez-Dias, U. Richter, I. Santos, U. Naslund, E. Gonzalez Lopez, M. Rover, H. Vago, A. E.-A. El-Shitany, G Teixido Tura, M. Sramko, J. Necas, S. Fennira, M. Gomez Bueno, L. Zakhama, L. Costanzo, H. Zemir, F. Dunstan, R. Pecoraro, R. Hocking, L. Gabrielli, R. Tan, J. Tintera, L. Pratali, V. Monivas, B. Bouzas Zubeldia, B. Segafredo, T. Leiria, R. Mincu, A. Kaczynska, L. Petrescu, J. M. Bosmans, A. Ben Yaala, A. Ploussi, K. Hu, Z. Frikha, L. De Luca, E. Choi, J. Yanez Wonenburger, I. Serbanoiu, C. Iacoboni, J. Trochu, S. Montserrat, X. Luo, E. Pavlukova, D. Martinez Ruiz, G. Lazaros, B. Tan, D. Hudziak, J. Petrovicova, S. Herrmann, P. Biaggi, E. Picano, I. E. Rodrigus, Y. Lam, M. Jeong, M. Fedorco, P. Beltran Correas, C. Felix, L. Polak, C. Wunderlich, S. Hohlfeld, S. Tripepi, M. Haberka, R. Poscia, L. Halmai, A. Luycx-Bore, K. Tunstall, D. Becker, H. Dave, P. Lemarchand, and M. Carvalho

Subjects
Leading edge, business.industry, Reference values, Healthy subjects, Medicine, Radiology, Nuclear Medicine and imaging, Geometry, General Medicine, Edge (geometry), Cardiology and Cardiovascular Medicine, business
Published
2012

36. The EURADOS-kit training course on Monte Carlo methods for the calibration of body counters

Author

D. Leone, M. A. Lopez, B. Breustedt, O. Marzocchi, J.M. Gómez-Ros, S. Poelz, A. L. Shutt, David Broggio, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), and Centro de Investigaciones Energéticas Medioambientales y Tecnológicas [Madrid] (CIEMAT)

Subjects
Engineering drawing, Course materials, Inservice Training, Process (engineering), Computer science, Training course, International Cooperation, [SDV]Life Sciences [q-bio], Monte Carlo method, Potassium Radioisotopes, 01 natural sciences, Whole-Body Counting, 030218 nuclear medicine & medical imaging, Formal evaluation, Iodine Radioisotopes, 03 medical and health sciences, 0302 clinical medicine, Radiation Monitoring, Germany, 0103 physical sciences, ComputingMilieux_COMPUTERSANDEDUCATION, Calibration, Humans, Radiology, Nuclear Medicine and imaging, Computer Simulation, Lung, Whole body counting, Radiation, Radiological and Ultrasound Technology, 010308 nuclear & particles physics, Phantoms, Imaging, Public Health, Environmental and Occupational Health, General Medicine, Cesium Radioisotopes, Radiation monitoring, Monte Carlo Method
Abstract

International audience; Monte Carlo (MC) methods are numerical simulation techniques that can be used to extend the scope of calibrations performed in in vivo monitoring laboratories. These methods allow calibrations to be carried out for a much wider range of body shapes and sizes than would be feasible using physical phantoms. Unfortunately, nowadays, this powerful technique is still used mainly in research institutions only. In 2013, EURADOS and the in vivo monitoring laboratory of Karlsruhe Institute of Technology (KIT) organized a 3-d training course to disseminate knowledge on the application of MC methods for in vivo monitoring. It was intended as a hands-on course centered around an exercise which guided the participants step by step through the calibration process using a simplified version of KIT's equipment. Only introductory lectures on in vivo monitoring and voxel models were given. The course was based on MC codes of the MCNP family, widespread in the community. The strong involvement of the participants and the working atmosphere in the classroom as well as the formal evaluation of the course showed that the approach chosen was appropriate. Participants liked the hands-on approach and the extensive course materials on the exercise. © The Author 2016. Published by Oxford University Press. All rights reserved.

Published
2016

37. NOTIZIARIO

Author

Zaccagnini, Guido, Sorrento, Luigi, and Mattei-Cerasoli, D. Leone

Published
1933

38. Monte Carlo modelling for the in vivo lung monitoring of enriched uranium: Results of an international comparison

Author

Telma Cristina Ferreira Fonseca, J.-A. Cruzate, Erick Cardenas-Mendez, D. Leone, Tomas Vrba, S. Gossio, L. Liu, Carla Oliveira, Gary H. Kramer, Jad Farah, Kevin Capello, C. Simões, Gianfranco Gualdrini, J. Bento, Uwe Reichelt, C. Li, B. Heide, M. Caldeira, L. C. Freire, A. Kyrieleis, David Broggio, J. Li, D. Sommer, M. A. Lopez, Filip Vanhavere, L.-C. Mihailescu, J. Huikari, Osamu Kurihara, D. Franck, M. Moraleda, J. F. Navarro, C. Konvalinka, M. Takahashi, N. Puerta, Pedro Teles, A. L. Lebacq, B. Perez, J.M. Gómez-Ros, J. G. Hunt, P. Cowan, Sakae Kinase, Laboratoire d'évaluation de la dose interne (DRPH/SDI/LEDI), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Instituto Tecnológico e Nuclear, Instituto Superior Técnico, Universidade Técnica de Lisboa (IST), Centre d'Etude de l'Energie Nucléaire (SCK-CEN), Technische Universität Dresden = Dresden University of Technology (TU Dresden), Department of Engineering Physics [Beijing], Tsinghua University [Beijing] (THU), Centro de Investigaciones Energéticas Medioambientales y Tecnológicas [Madrid] (CIEMAT), Autoridad Regulatoria Nuclear (ARN), Escola Superior de Tecnologia da Saude de Lisboa, Radiation and Nuclear Safety Authority [Helsinki] (STUK), Instituto de Radioproteção e Dosimetria, Japan Atomic Energy Agency, Faculty of Nuclear Sciences and Physical Engineering [Prague] (FJFI CTU), Czech Technical University in Prague (CTU), and Agenzia Nazionale per le nuove Tecnologie, l’energia e lo sviluppo economico sostenibile (ENEA)

Subjects
medicine.medical_specialty, [SDV]Life Sciences [q-bio], Nuclear engineering, Monte Carlo method, In-vivo measurement, Voxel phantoms, Monte carlo computation, Enriched uranium, Imaging phantom, 030218 nuclear medicine & medical imaging, Counting system, 03 medical and health sciences, 0302 clinical medicine, In-vivo, MC simulation, MONTE CARLO, Calibration, medicine, Numerical calibration, Internal dosimetry, Medical physics, Instrumentation, International comparison, Intercomparisons, Radiation, Monte Carlo modelling, Counting efficiency, Monte Carlo methods, Computer simulation, 030220 oncology & carcinogenesis, Uranium, Environmental science, Experiments
Abstract

In order to assess the reliability of Monte Carlo (MC)-based numerical calibration of in vivo counting systems the EURADOS network supported a comparison of MC simulation of well-defined experiments. This action also provided training for the use of voxel phantoms. In vivo measurements of enriched uranium in a thoracic phantom have been carried out and the needed information to simulate these measurements was distributed to 17 participants. About half of the participants managed to simulate the measured counting efficiency without support from the organisers. Following additional support all participants managed to simulate the counting efficiencies within a typical agreement of ±5% with experiment. © 2012 Elsevier Ltd. All rights reserved.

Published
2012

39. Nutritional status in a cohort of children with type 1 and 2 spinal muscular atrophy

Author

C. Palermo, A. Ciliberti, D. Panico, S. Filoni, V. Giorgio, E. Blasi, F. Proli, D. Leone, and Marika Pane

Subjects
Pediatrics, medicine.medical_specialty, Physical medicine and rehabilitation, Hepatology, business.industry, Cohort, Gastroenterology, medicine, Nutritional status, Spinal muscular atrophy, medicine.disease, business
Published
2017

40. Simulation of phoswich detectors using MCNPX and EGSNRC

Author

B. Breustedt and D. Leone

Subjects
Physics::Instrumentation and Detectors, Monte Carlo method, Cesium, Sodium Iodide, Crystal, Radiation Monitoring, Humans, Radiology, Nuclear Medicine and imaging, Radiometry, Lung, Physics, Photons, Americium, Radiation, Radiological and Ultrasound Technology, Germanium, Detector, Public Health, Environmental and Occupational Health, Equipment Design, General Medicine, Iodides, Computational physics, Semiconductor detector, Monte carlo code, Monte Carlo Method, Algorithms, Software
Abstract

The in vivo monitoring Lab at KIT uses two phoswich detectors for routine lung counting. A simplified model of one of them has been implemented in the two Monte Carlo codes EGSnrc and MCNPX. The active part of the detector consists of a crystal of NaI(Tl) and one of CsI(Tl): the energy deposited in both the crystals have been studied to consider the effect of the anticoincidence logic, present in the read-out electronics of the detectors and not yet studied with Monte Carlo simulations. Only the NaI(Tl) crystal has then been used to study the escape peaks at several energies, which are more prominent at low energies. The results from the two codes have been compared. The comparison of the codes predictions for the escape peaks has been then extended using the model of a germanium detector.

Published
2010

41. Poster session IV * Friday 10 December 2010, 14:00-18:00

Author

B. Mora, E. Base, W. Schmid, M. Andreas, U. Weber, M. Junreitmaier, F. Foerster, M. Hiesmayr, H. D. Tschernich, D. Guldbrand, O. Goetzsche, B. Eika, S. Fumagalli, S. Francini, D. Gabbai, S. Pedri, M. Casalone Rinaldi, Y. Makhanian, R. Sollami, F. Tarantini, N. Marchionni, P. M. Azcarate, S. Castano, M. Rodriguez-Manero, M. Arraiza, B. Levy, J. Barba, G. Rabago, G. Bastarrika, H. Rus, M. Radoi, C. Ciurea, D. Boda, T. Erdei, M. Denes, A. Mihalcz, A. Kardos, C. S. Foldesi, A. Temesvari, M. Lengyel, M. Cameli, M. Lisi, F. Righini, P. Ballo, M. Henein, S. Mondillo, S. Nistri, M. Galderisi, P. C. Ballo, L. Pagliani, I. Olivotto, A. Santoro, B. Papesso, P. Innelli, F. Cecchi, K. Hristova, T. Z. Katova, V. Kostova, Y. Simova, N. Nesheva, B. Ivanovic, M. T. Tadic, D. S. Simic, C. M. Rao, D. Aguglia, G. Casciola, C. Imbesi, A. Marvelli, M. Sgro, D. Benedetto, G. Tripepi, C. Zoccali, F. A. Benedetto, L. Mantziari, V. Kamperidis, E. Damvopoulou, I. Ventoulis, G. Giannakoulas, S. Paraskevaidis, V. Vassilikos, H. Karvounis, I. H. Styliadis, T. K. Sonder, B. B. Loegstrup, J. Lambrechtsen, L. M. Van Bortel, P. Segers, K. Egstrup, A. Tho, P. Moceri, D. Bertora, P. Gibelin, E. J. Cho, K. Y. Choi, B. J. Kim, D. B. Kim, S. W. Jang, C. S. Park, H. O. Jung, H. K. Jeon, H. J. Youn, J. H. Kim, E. Donal, N. Coquerel, S. Bodi, C. Thebault, G. Kervio, F. Carre, M. J. Daly, S. L. Fairley, R. Doherty, K. Ashfield, R. Kirkpatrick, B. Smith, J. Buchanan, L. Hill, L. J. Dixon, M. Rosca, K. O' Connor, J. Magne, G. Romano, A. Calin, B. A. Popescu, C. C. Beladan, L. Pierard, C. Ginghina, P. Lancellotti, T. Bochenek, K. Wita, Z. Tabor, M. Grabka, M. Elzbieciak, M. Trusz-Gluza, O. Moreau, C. Leclercq, A. Sahlen, K. Shahgaldi, A. Aminoff, P. Aagaard, A. Manouras, R. Winter, E. Ehrenborg, F. Braunschweig, G. Bedetti, L. Gargani, C. Pizzi, R. Sicari, E. Picano, J. Zhang, H. B. Zhang, Y. Y. Duan, L. L. Chen, J. Li, L. W. Liu, T. Zhu, H. L. Li, H. L. Su, X. D. Zhou, M. Ruiz Ortiz, D. Mesa Rubio, M. Delgado Ortega, E. Romo Penas, F. Toledano Degado, C. Leon Del Pino, J. Lopez Aguilera, E. Villanueva Fernandez, L. Cejudo Diaz Del Campo, J. Suarez De Lezo, E. Abergel, M. Simon, P. Dehant, E. Bogino, M. Jimenez, J. C. Verdier, C. Chauvel, A. E. Albertsen, J. C. Nielsen, P. T. Mortensen, H. Egeblad, G. M. Nasr, S. Tawfik, A. Omar, M. Olofsson, K. Boman, N. Rezzoug, B. Vaes, J. Degryse, J.-L. Vanoverschelde, A. A. Pasquet, D. Poggio, M. Bonadies, V. Pacher, S. Mazzetti, M. Grillo, E. D'elia, T. Khouri, G. Specchia, C. Mornos, D. Rusinaru, D. Cozma, A. Ionac, L. Petrescu, R. Rotzak, Y. Rosenman, R. D. Patterson, S. Ratnatheepan, R. G. Bogle, B. Goebel, O. Gjesdal, D. Kottke, S. Otto, C. Jung, T. Edvardsen, H. R. Figulla, T. C. Poerner, T. Otsuka, M. Suzuki, H. Yoshikawa, G. Hashimoto, N. Itou, T. Ono, M. Yamamoto, T. Osaki, T. Tsuchida, K. Sugi, T. Wolber, L. Haegeli, D. Huerlimann, C. Brunckhorst, F. Duru, Z. M. Wu, X. H. Shu, L. L. Dong, B. Fan, J. B. Ge, M. Greutmann, D. Tobler, P. Biaggi, M. Mah, A. Crean, E. N. Oechslin, C. K. Silversides, S. Giusca, R. Jurcut, I. Ghiorghiu, I. M. Coman, M. Amzulescu, R. Ionescu, M. Delcroix, J. U. Voigt, R. Piatkowski, J. Kochanowski, P. Scislo, M. Grabowski, M. Marchel, M. Roik, D. Kosior, G. Opolski, A. M. Maceira Gonzalez, J. Cosin-Sales, E. Dalli, B. Igual, J. V. Monmeneu, P. Lopez-Lereu, J. Estornell, J. Ruvira, J. Sotillo, A. Stevanovic, A. Toncev, S. Dimkovic, M. Dekleva, N. Paunovic, D. Toncev, N. Sekularac, O. Yildirimturk, F. F. Helvacioglu, Y. Tayyareci, S. Yurdakul, I. C. C. Demiroglu, S. Aytekin, M. Pinedo Gago, I. Amat Santos, A. Revilla Orodea, J. Lopez Diaz, R. Arnold, L. De La Fuente Galan, A. Recio Platero, I. Gomez Salvador, A. Puerto Sanz, J. A. San Roman Calvar, R. Yotti, J. Bermejo, T. Mombiela, Y. Benito, P. L. Sanchez, J. Solis, R. Prieto, F. Fernandez-Aviles, R. Zilberszac, H. Gabriel, S. Graf, G. Mundigler, G. Maurer, R. Rosenhek, C. Zito, J. Salvia, C. Longordo, D. Donato, E. Alati, M. Miceli, A. Pardeo, S. Arcidiaco, G. Oreto, S. Carerj, S. Hadjimiltiades, G. Sianos, K. Anastasiadis, V. Grosomanidis, G. Efthimiadis, G. Parcharidis, M. Yousry, A. Rickenlund, J. Petrini, T. Gustafsson, J. Liska, A. Hamsten, P. Eriksson, A. Franco-Cereceda, M. J. Eriksson, K. Caidahl, K. Mizia-Stec, P. Pysz, M. Jasinski, A. Drzewiecka-Gerber, M. Krejca, A. Bochenek, S. Wos, Z. Gasior, M. Tendera, K. Niki, M. Sugawara, I. Takamisawa, H. Watanabe, T. Sumiyoshi, S. Hosoda, T. Ida, S. Takanashi, N. T. Olsen, P. Sogaard, C. Jons, R. Mogelvang, H. B. W. Larsson, J. P. Goetze, O. W. Nielsen, T. Fritz-Hansen, N. Sayar, A. L. Orhan, H. B. Erer, M. Eren, H. Atmaca, H. Y. Yilmaz, N. Cakmak, S. Altay, S. Terzi, K. Yesilcimen, R. Garcia Orta, E. Moreno, M. Lopez, I. Uribe, M. Vidal, M. F. Ruiz-Lopez, M. Gonzalez-Molina, J. M. Oyonarte, S. Lopez, J. Azpitarte, C. Szymanski, R. A. Levine, H. Zheng, M. D. Handschumacher, A. Tawakol, J. Hung, F. Le Ven, Y. Etienne, Y. Jobic, I. Frachon, P. Castellant, M. Fatemi, J. J. Blanc, C. Tribouilloy, F. Grigioni, J.-F. Avierinos, A. Barbieri, O. Buiciuc, M. Enriquez-Sarano, K. Said, A. K. Farag, M. El-Ramly, H. Rizk, A. Iorio, B. Pinamonti, M. Bobbo, M. Merlo, L. Massa, G. Faganello, A. Di Lenarda, G. Sinagra, R. Margato, H. Ribeiro, C. Ferreira, A. Matias, P. Fontes, J. I. Moreira, A. Milan, E. Puglisi, C. Magnino, A. Fabbri, D. Leone, A. Vairo, V. Crudo, A. Iannaccone, V. Milazzo, F. Veglio, N. Maroz-Vadalazhskaya, I. Ostrovskiy, E. Imbalzano, A. Saitta, M. Cusma-Piccione, G. Di Bella, R. Nava, M. Ferro, G. Falanga, A. Frigy, J. Buzogany, C. S. Szabados, L. Dan, E. Carasca, I. Ikonomidis, J. Lekakis, S. Tzortzis, D. T. Kremastinos, C. Papadopoulos, I. Paraskevaidis, H. Triantafyllidi, P. Trivilou, K. Venetsanou, M. Anastasiou-Nana, K. Wierzbowska-Drabik, M. Kurpesa, E. Trzos, T. Rechcinski, M. Mozdzan, J. D. Kasprzak, W. Kosmala, T. Kotwica, M. Przewlocka-Kosmala, A. Mysiak, D. Skultetyova, S. Filipova, P. Chnupa, G. Pechlivanidis, H. Dimitroula, W.-C. Tsai, Y.-W. Liu, C.-C. Lin, Y.-Y. Huang, L.-M. Tsai, S. M. Park, Y. H. Kim, S. M. Shin, W. J. Shim, A. Gonzalez Mansilla, J. Torres Macho, V. Sanchez Sanchez, P. Diez, J. Delgado, S. Borruel, C. Saenz De La Calzada, S. Pyxaras, M. Valentincic, G. Barbati, F. Lo Giudice, A. Perkan, S. Magnani, T. Palecek, D. Ambroz, P. Jansa, J. Lindner, M. Vitovec, P. Polacek, K. Jiratova, A. Linhart, M. Baskurt, G. M. Dogan, O. Abaci, A. Kaya, S. Kucukoglu, A. Duszanska, T. Kukulski, I. Skoczylas, A. Majsnerowska, A. Nowowiejska-Wiewiora, W. Streb, M. Szulik, L. Polonski, Z. Kalarus, P. O. Yerly, M. Prella, A. Joly, L. Nicod, J. D. Aubert, N. Aebischer, H. Dores, S. Leal, I. Rosario, M. J. Correia, J. Monge, A. M. Grilo, I. Arroja, C. Fonseca, A. Aleixo, A. Silva, E. Perez-David, M. Sanchez-Alegre, I. Gomez Anta, J. De La Torre, J. Alarcon, J. A. Garcia Robles, J. Lafuente, C. J. Garcia Alonso, N. Vallejo Camazon, A. Gonzalez Guardia, R. Nunez, C. Bosch Carabante, L. Mateu, F. Gual Capllonch, E. Ferrer Sistach, J. Lopez Ayerbe, A. Bayes Genis, A. Tomaszewski, A. Kutarski, M. Tomaszewski, D. Bramos, A. Kalantaridou, D. Takos, E. Skaltsiotis, C. Trika, N. Tsirikos, C. Pamboukas, G. Kottis, S. Toumanidis, C. Aggeli, I. Felekos, G. Roussakis, C. Kazazaki, K. Lampropoulos, S. Lagoudakou, C. Stergiou, C. Pitsavos, C. Stefanadis, C. Kihara, K. Murata, Y. Wada, T. Tanaka, K. Uchida, S. Okuda, T. Susa, M. Matsuzaki, A. Abrahamsson, P. Gudmundsson, L. Brodin, F. Knebel, S. Schattke, W. Sanad, I. Schimke, S. Schroeckh, L. Brechtel, J. Lock, R. Makauskiene, G. Baumann, A. C. Borges, H. E. Moelmen-Hansen, U. Wisloff, I. L. Aamot, A. Stoylen, C. B. Ingul, M.-E. Estensen, J. O. Beitnes, G. Grindheim, T. Henriksen, L. Aaberge, O. A. Smiseth, L. Gullestad, S. Aakhus, G. Agoston, A. Moggi Pignone, E. Capati, L. Badano, A. Moreo, S. Bombardieri, A. Varga, M. Carrideo, S. Faricelli, A. Corazzini, R. Ippedico, B. Ruggieri, A. Di Blasio, E. D'angelo, A. Di Baldassarre, P. Ripari, S. Gallina, A. Kentrschynskyj, B. Hylander, S. Jacobson, A. Pagels, S. I. Dumitrescu, I. Tintoiu, V. Greere, G. Cristian, L. Chiriac, F. Pinte, I. Droc, G. Neagoe, S. Stanciu, V. A. Voicu, A. Kuch-Wocial, P. Pruszczyk, C. A. Szmigielski, M. Szulc, G. Styczynski, M. Sinski, A. Kaczynska, A. Ryabikov, S. Malyutina, J. Halcox, M. Bobak, Y. U. Nikitin, M. Marmot, D. Barbosa, G. Kiss, F. Orderud, B. Amundsen, R. Jasaityte, D. Loeckx, P. Claus, H. Torp, J. D'hooge, J. T. Kuhl, J. Lonborg, A. Fuchs, M. Andersen, N. Vejlstrup, T. Engstrom, J. E. Moller, K. F. Kofoed, L. A. Smith, A. Bhan, M. Paul, M. J. Monaghan, B. Zaborska, S. Stec, M. Sikora-Frac, T. Krynski, P. Kulakowski, K. Pushparajah, D. Dashwood, A. Barlow, K. Nugent, O. Miller, J. Simpson, N. Valeur, M. K. Ersboll, J. Kjaergaard, R. Greibe, N. Risum, C. Hassager, L. Kober, D. Popovic, I. Nedeljkovic, M. Petrovic, B. Vujisic-Tesic, A. Arandjelovic, S. Stojiljkovic, B. Jakovljevic, S. Damjanovic, M. Ostojic, I. A. Agrios, D. B. Bramos, H. S. Skaltsiotis, D. T. Takos, A. Kaladaridis, N. V. Vasiladiotis, G. K. Kottis, A. A. Antoniou, C. P. Pamboucas, S. T. T. Toumanidis, G. Locorotondo, I. Porto, L. Paraggio, E. Fedele, S. Barchetta, A. R. De Caterina, A. G. Rebuzzi, F. Crea, L. Galiuto, P. Lipiec, E. Szymczyk, B. Michalski, B. Wozniakowski, L. Stefanczyk, A. Rotkiewicz, A. Shim, J. Vainer, J. Habets, A. Lousberg, C. Pont De, J. Waltenberger, H. Farouk, H. Heshmat, A. Adel, K. El Chilali, Y. Baghdady, K. Sorour, U. Gustafsson, M. Larsson, A. Bjallmark, P. Lindqvist, R. A'roch, M. Haney, A. Waldenstrom, Z. Mladenovic, D. Tavciovski, Z. Mijailovic, A. Djordjevic - Dikic, S. Obradovic, R. Matunovic, Z. Jovic, P. Djuric, S. Aase, H. Dalen, T. Sarkola, A. N. Redington, F. Keeley, T. Bradley, E. Jaeggi, and H. Sahlen

Subjects
medicine.medical_specialty, medicine.anatomical_structure, Myocardial ischemia, business.industry, Ventricle, Internal medicine, Cardiology, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine, business, Rotation
Published
2010

42. Study of the a0(980) meson via the radiative decay ϕ→ηπ0γ with the KLOE detector

Author

G. Capon, G. Saracino, S. Fiore, G. F. Xu, S. Bertolucci, Simona Serena Bocchetta, P. Massarotti, S. Meola, E. Graziani, G. Chiefari, C. Di Donato, Barbara Sciascia, M. Martini, S. Chi, G. Lanfranchi, P. Gauzzi, C. Bloise, T. Spadaro, R. Versaci, V. V. Kulikov, G. Felici, S. Müller, Francesco Lacava, C. Bacci, F. Archilli, Edoardo Gorini, Massimo Antonelli, P. Santangelo, P. Ciambrone, Vincenzo Patera, W. Kluge, Alessandra Doria, A.L. Sibidanov, S. Miscetti, F. Perfetto, A. Denig, A. Sciubba, M. Moulson, A. De Santis, F. Ceradini, B. Di Micco, E. De Lucia, Claudio Gatti, M. Testa, M. Palutan, Enrico Pasqualucci, F. Bossi, S. Giovannella, Margherita Primavera, P. Valente, A. Ferrari, A. Passeri, W. Mei, P. Beltrame, P. De Simone, P. Branchini, D. Leone, M. Dreucci, C. Forti, G. Venanzoni, Pierluigi Campana, A. Di Domenico, M. L. Ferrer, G. De Zorzi, F. Murtas, M. Napolitano, F. Ambrosino, R. Volpe, P. Franzini, F. Nguyen, J. Lee-Franzini, G. Bencivenni, T. Capussela, Cesare Bini, A. Antonelli, and L. Tortora

Subjects
Physics, Nuclear physics, Nuclear and High Energy Physics, Particle decay, Pion, Meson, Branching fraction, Electron–positron annihilation, Hadron, Particle identification, Dimensionless quantity
Abstract

We have studied the ϕ → a 0 ( 980 ) γ process with the KLOE detector at the Frascati ϕ-factory DAΦNE by detecting the ϕ → η π 0 γ decays in the final states with η → γ γ and η → π + π − π 0 . We have measured the branching ratios for both final states: Br ( ϕ → η π 0 γ ) = ( 7.01 ± 0.10 ± 0.20 ) × 10 − 5 and ( 7.12 ± 0.13 ± 0.22 ) × 10 − 5 , respectively. We have also extracted the a 0 ( 980 ) mass and its couplings to η π 0 , K + K − , and to the ϕ meson from the fit of the η π 0 invariant mass distributions using different phenomenological models.

Published
2009

43. Measurement of the branching ratio and search for a CP violating asymmetry in the η→π+π−e+e−(γ) decay at KLOE

Author

Massimo Antonelli, P. Beltrame, Enrico Pasqualucci, S. Fiore, D. Leone, G. Felici, E. Graziani, Achim Denig, Filippo Ceradini, S. Bertolucci, B. Di Micco, R. Versaci, Paolo Ciambrone, T. Spadaro, Stefan E. Müller, S. Meola, F. Bossi, A. Antonelli, S. Bocchetta, P. Gauzzi, G. Capon, L. Tortora, A. Passeri, G. F. Xu, C. Di Donato, Paolo Santangelo, F. Murtas, P. Massarotti, Barbara Sciascia, M. Martini, P. De Simone, F. Nguyen, F. Perfetto, M. Napolitano, G. Lanfranchi, S. Miscetti, Vincenzo Patera, M. Palutan, A. Di Domenico, Claudio Gatti, C. Bloise, M. Moulson, P. Valente, A. De Santis, F. Crucianelli, G. Venanzoni, M. Testa, G. De Zorzi, G. Bencivenni, Cesare Bini, F. Ambrosino, Juliet Lee-Franzini, S. Giovannella, P. Franzini, P. Branchini, M. Dreucci, E. De Lucia, Flavio Archilli, and T. Capussela

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Meson, Branching fraction, media_common.quotation_subject, Gamma ray, Pi, Radiative transfer, CP violation, Asymmetry, media_common
Abstract

We have studied the η → π + π − e + e − ( γ ) decay using about 1.7 fb − 1 collected by the KLOE experiment at the DAΦNE ϕ -factory. This corresponds to about 72 millions η mesons produced in ϕ radiative decays. We have measured the branching ratio, inclusive of radiative effects, with 4% accuracy: BR ( η → π + π − e + e − ( γ ) ) = ( 26.8 ± 0.9 Stat . ± 0.7 Syst . ) × 10 − 5 . We have obtained the first measurement of the CP-odd ππ – ee decay planes angular asymmetry, A ϕ = ( − 0.6 ± 2.5 Stat . ± 1.8 Syst . ) × 10 − 2 .

Published
2009

44. Search for the KS→e+e− decay with the KLOE detector

Author

Massimo Antonelli, S. Bocchetta, Enrico Pasqualucci, P. Gauzzi, A.L. Sibidanov, G. Lanfranchi, A. Denig, M. Moulson, P. Franzini, P. Branchini, M. Dreucci, A. De Santis, Paolo Santangelo, Pierluigi Campana, F. Nguyen, F. Murtas, P. Valente, Filippo Ceradini, Stefan E. Müller, C. Di Donato, F. Perfetto, T. Capussela, Juliet Lee-Franzini, Paolo Ciambrone, D. Capriotti, M. Palutan, Cesare Bini, G. Venanzoni, Vincenzo Patera, S. Giovannella, A. Sciubba, G. Felici, D. Leone, V. V. Kulikov, M. L. Ferrer, G. De Zorzi, P. De Simone, A. Antonelli, M. Testa, F. Ambrosino, F. Crucianelli, M. Napolitano, A. Passeri, A. Di Domenico, S. Bertolucci, S. Meola, L. Tortora, S. Miscetti, T. Spadaro, F. Bossi, Claudio Gatti, C. Bloise, P. Beltrame, G. Bencivenni, P. Massarotti, Barbara Sciascia, M. Martini, B. Di Micco, G. Capon, S. Fiore, E. Graziani, R. Versaci, W. Kluge, E. De Lucia, and Flavio Archilli

Subjects
Physics, Nuclear physics, Nuclear and High Energy Physics, Luminosity (scattering theory), Electron–positron annihilation, Detector, Direct search, Particle identification, Order of magnitude, Calorimeter
Abstract

We present the result of a direct search for the decay K S → e + e − , obtained with a sample of e + e − → ϕ → K S K L events produced at DAΦNE, the Frascati ϕ-factory, for an integrated luminosity of 1.9 fb−1. The search has been performed using a pure K S beam tagged by the simultaneous detection of a K L interaction in the calorimeter. Background rejection has been optimized by using both kinematic and particle identification cuts. We find BR ( K S → e + e − ) 9 × 10 − 9 at 90% CL, which improves by an order of magnitude on the previous best limit.

Published
2009

45. Scalar mesons at KLOE

Author

A. Ferrari, G. Lanfranchi, P. Branchini, M. Dreucci, A.L. Sibidanov, C. Bacci, Cesare Bini, F. Ceradini, B. Di Micco, C. Bloise, R. Versaci, G. Felici, P. Ciambrone, Edoardo Gorini, Enrico Pasqualucci, G. Saracino, S. Bocchetta, Francesco Lacava, Margherita Primavera, S. Miscetti, F. Perfetto, V. V. Kulikov, P. De Simone, S. Chi, S. Müller, P. Franzini, T. Capussela, A. Passeri, Vincenzo Patera, C. Forti, M. Testa, Massimo Antonelli, D. Leone, A. Sciubba, M. Napolitano, G. De Zorzi, A. Di Domenico, F. Ambrosino, G. Venanzoni, Andrea Doria, M. L. Ferrer, A. Antonelli, J. Lee-Franzini, Paolo Valente, P. Santangelo, S. Fiore, M. Moulson, E. Graziani, A. De Santis, W. Kluge, S. Meola, F. Murtas, P. Gauzzi, L. Tortora, A. G. Denig, E. De Lucia, G. Chiefari, C. Di Donato, G. Capon, P. Beltrame, S. Bertolucci, T. Spadaro, G. Bencivenni, M. Palutan, Claudio Gatti, F. Archilli, F. Bossi, W. Mei, G. F. Xu, P. Massarotti, Barbara Sciascia, M. Martini, F. Nguyen, F. Crucianelli, P. Campana, S. Giovannella, Ambrosino, Fabio, Chiefari, Giovanni, C., Di Donato, A., Doria, Massarotti, Paolo, Napolitano, Marco, and Saracino, Giulio

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Meson, Atomic and Molecular Physics, Scalar (mathematics), and Optics, Atomic and Molecular Physics, and Optics
Abstract

New results concerning the scalar mesons f 0 ( 980 ) produced in the ϕ → π π γ decays, and the a 0 ( 980 ) scalar mesons in the ϕ → a 0 ( 980 ) γ → η π 0 γ decays, are presented.

Published
2009

46. Measurement of σ(e+e−→π+π−γ(γ)) and the dipion contribution to the muon anomaly with the KLOE detector

Author

Enrico Pasqualucci, S. Bertolucci, B. Di Micco, G. Saracino, R. Versaci, F. Bossi, G. Bencivenni, P. De Simone, V. V. Kulikov, T. Spadaro, G. De Zorzi, Cesare Bini, S. Müller, Francesco Lacava, S. Meola, F. Ambrosino, Paolo Santangelo, Pierluigi Campana, F. Murtas, W. Mei, M. Moulson, A. De Santis, P. Massarotti, S. Miscetti, Barbara Sciascia, F. Perfetto, B. Valeriani, M. Martini, S. Fiore, G. Lanfranchi, C. Bacci, Filippo Ceradini, C. Forti, E. Graziani, P. Branchini, M. Dreucci, P. Franzini, G. Capon, M. Napolitano, G. Xu, Claudio Gatti, Massimo Antonelli, A. Di Domenico, W. Kluge, Juliet Lee-Franzini, Paolo Ciambrone, A.L. Sibidanov, M. Incagli, S. Giovannella, P. Beltrame, E. De Lucia, S. Di Falco, F. Archilli, M. Testa, G. Felici, Alessandra Doria, A. Denig, M. Martemianov, Simona Serena Bocchetta, G. Chiefari, C. Di Donato, C. Bloise, Edoardo Gorini, P. Valente, Margherita Primavera, A. Ferrari, S. Chi, F. Crucianelli, T. Capussela, D. Leone, Vincenzo Patera, F. Nguyen, A. Sciubba, M. Palutan, P. Gauzzi, A. Antonelli, L. Tortora, A. Passeri, G. Venanzoni, and M. L. Ferrer

Subjects
Nuclear physics, Physics, Nuclear and High Energy Physics, Particle physics, Luminosity (scattering theory), Muon, Pion, Photon, Electron–positron annihilation, Form factor (quantum field theory), Radiation, Anomaly (physics)
Abstract

We have measured the cross section σ ( e + e − → π + π − γ ( γ ) ) at DAΦNE, the Frascati ϕ-factory, using events with initial state radiation photons emitted at small angle and inclusive of final state radiation. We present the analysis of a new data set corresponding to an integrated luminosity of 240 pb−1. We have achieved a reduced systematic uncertainty with respect to previously published KLOE results. From the cross section we obtain the pion form factor and the contribution to the muon magnetic anomaly from two-pion states in the mass range 0.592 M π π 0.975 GeV . For the latter we find Δ π π a μ = ( 387.2 ± 0.5 stat ± 2.4 exp ± 2.3 th ) × 10 −10 .

Published
2009

47. Study of the process e+e−→ωπ0 in the ϕ-meson mass region with the KLOE detector

Author

Cesare Bini, G. F. Xu, P. Franzini, W. Kluge, R. Versaci, P. Massarotti, S. Bocchetta, Barbara Sciascia, M. Martini, Enrico Pasqualucci, G. Bencivenni, S. Miscetti, P. De Simone, M. Testa, D. Leone, M. Moulson, A. De Santis, F. Bossi, B. Di Micco, P. Valente, F. Archilli, S. Müller, Massimo Antonelli, P. Beltrame, M. Napolitano, G. Lanfranchi, T. Capussela, G. Capon, L. Tortora, Paolo Santangelo, Pierluigi Campana, P. Branchini, A. Di Domenico, M. Dreucci, Filippo Ceradini, F. Murtas, Claudio Gatti, C. Bloise, S. Fiore, E. Graziani, F. Perfetto, G. Venanzoni, A. Antonelli, M. L. Ferrer, P. Gauzzi, Juliet Lee-Franzini, Paolo Ciambrone, S. Giovannella, A. G. Denig, E. De Lucia, A.L. Sibidanov, C. Di Donato, A. Passeri, F. Nguyen, Vincenzo Patera, A. Sciubba, S. Meola, G. De Zorzi, F. Ambrosino, M. Palutan, G. Felici, F. Crucianelli, S. Bertolucci, and T. Spadaro

Subjects
Nuclear physics, Physics, Nuclear and High Energy Physics, Meson, Branching fraction, Electron–positron annihilation, Atomic physics
Abstract

We have studied the e + e − → ω π 0 cross section in the s interval 1000–1030 MeV using the π + π − π 0 π 0 and π 0 π 0 γ final states with a sample of ∼ 600 pb −1 collected with the KLOE detector at DAΦNE. By fitting the observed interference pattern around M ϕ for both final states, we extract the ratio of the decay widths Γ ( ω → π 0 γ ) / Γ ( ω → π + π − π 0 ) = 0.0897 ± 0.0016 and derive the branching fractions BR ( ω → π + π − π 0 ) = ( 90.24 ± 0.19 ) % , BR ( ω → π 0 γ ) = ( 8.09 ± 0.14 ) % . The parameters describing the e + e − → π + π − π 0 π 0 reaction around M ϕ are also used to extract the branching fraction for the OZI and G-parity violating ϕ → ω π 0 decay: BR ( ϕ → ω π 0 ) = ( 4.4 ± 0.6 ) × 10 −5 .

Published
2008

48. Measurement of the absolute branching ratio of the K+→π+π0(γ) decay with the KLOE detector

Author

F. Ambrosino, A. Antonelli, M. Antonelli, F. Archilli, C. Bacci, P. Beltrame, G. Bencivenni, S. Bertolucci, C. Bini, C. Bloise, S. Bocchetta, F. Bossi, P. Branchini, P. Campana, G. Capon, T. Capussela, F. Ceradini, F. Cesario, S. Chi, G. Chiefari, P. Ciambrone, F. Crucianelli, E. De Lucia, A. De Santis, P. De Simone, G. De Zorzi, A. Denig, A. Di Domenico, C. Di Donato, B. Di Micco, A. Doria, M. Dreucci, G. Felici, A. Ferrari, M.L. Ferrer, S. Fiore, C. Forti, P. Franzini, C. Gatti, P. Gauzzi, S. Giovannella, E. Gorini, E. Graziani, W. Kluge, V. Kulikov, F. Lacava, G. Lanfranchi, J. Lee-Franzini, D. Leone, M. Martemianov, M. Martini, P. Massarotti, W. Mei, S. Meola, S. Miscetti, M. Moulson, S. Müller, F. Murtas, M. Napolitano, F. Nguyen, M. Palutan, E. Pasqualucci, A. Passeri, V. Patera, F. Perfetto, M. Primavera, P. Santangelo, G. Saracino, B. Sciascia, A. Sciubba, A. Sibidanov, T. Spadaro, M. Testa, L. Tortora, P. Valente, G. Venanzoni, R. Versaci, and G. Xu

Subjects
Nuclear and High Energy Physics
Published
2008

49. Tests of CPT and Quantum Mechanics: experiment

Author

M. Moulson, A. De Santis, Francesco Lacava, Juliet Lee-Franzini, C. Forti, F. Perfetto, M. Napolitano, M. A. Matsyuk, Andrea Doria, Luca Tortora, V. V. Kulikov, Enrico Pasqualucci, B. Valeriani, F. Cervelli, Ludovico Pontecorvo, M. Testa, G. Lanfranchi, G. Venanzoni, A. Di Domenico, E. De Lucia, M. L. Ferrer, P. De Simone, P. Campana, S. Dell'Agnello, M. Martemianov, Margherita Primavera, Paolo Santangelo, W. Mei, S. Chi, S. Giovannella, F. Murtas, E. Spiriti, L. Passalacqua, D. Leone, P. Massarotti, T. Spadaro, S. Bocchetta, Barbara Sciascia, M. Martini, P. Branchini, M. Dreucci, M. Barva, S. Fiore, F. Nguyen, A. G. Denig, Stefano Veneziano, D. Bowring, E. Graziani, S. Bertolucci, S. Ventura, Claudio Gatti, A. Ventura, R. Messi, G. Chiefari, E. Santovetti, M. Palutan, C. Di Donato, T. Capussela, G. Capon, B. Di Micco, C. Bacci, Cesare Bini, Filippo Ceradini, G. Carboni, S. Conetti, W. Kluge, S. Di Falco, G. Felici, M. Incagli, R. D. Schamberger, P. Beltrame, S. Miscetti, G. Saracino, Fabrizio Scuri, Paolo Ciambrone, F. Ambrosino, M. Antonelli, R. Caloi, S. Meola, G. Finocchiaro, A. Antonelli, A.L. Sibidanov, I. Villella, V. Bocci, M. Tabidze, G. De Zorzi, A. Passeri, P. Gauzzi, R. Versaci, A. Farilla, Igor Sfiligoi, Edoardo Gorini, F. Bossi, G. Xu, C. Bloise, P. Franzini, S. Müller, S. A. Bulychjov, G. Bencivenni, Vincenzo Patera, A. Sciubba, P. Valente, and A. Ferrari

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Quantum decoherence, T-symmetry, CPT symmetry, Quantum mechanics, High Energy Physics::Phenomenology, Quantum interference, Time evolution, High Energy Physics::Experiment, Atomic and Molecular Physics, and Optics, Communication channel
Abstract

Neutral kaons provide one of the systems most sensitive to quantum mechanics and CPT violation. Models predicting quantum mechanics violation, also related to CPT violation, have been tested at the CPLEAR and KLOE experiments. In this report results of CPLEAR obtained by studying the time evolution of single and two entangled kaons are reviewed. New or improved limits on decoherence and CPT violation parameters have been obtained by KLOE studying the quantum interference in the channel ϕ → K S K L → π + π − π + π − . No deviations from the expectations of quantum mechanics and CPT symmetry have been observed.

Published
2007

50. EURADOS 241Am skull measurement intercomparison

Author

A. L. Lebacq, B. Pérez-López, A. L. Shutt, Sergei Y. Tolmachev, J. Scott, D. Franck, J. Huikari, M. A. Lopez, B. Breustedt, Jakub Ośko, W. Buchholz, Barry M. Hauck, Timothy P. Lynch, Karin Fantinova, David Broggio, Chunsheng Li, I. Malatova, Kevin Capello, Tomas Vrba, P. Fojtík, D. Leone, O. Marzocchi, George Etherington, T. Pliszczyński, Pedro Alves Nogueira, J.F. Navarro-Amaro, W. Rühm, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Centro de Investigaciones Energéticas Medioambientales y Tecnológicas [Madrid] (CIEMAT), National Center for Nuclear Research (NCBJ), Washington State University (WSU), Helmholtz-Zentrum München (HZM), Czech Technical University in Prague (CTU), Federal Office for Radiation Protection (BfS), Radiation and Nuclear Safety Authority [Helsinki] (STUK), Karlsruhe Institute of Technology (KIT), Centre d'Etude de l'Energie Nucléaire (SCK-CEN), and 02NUK015BU.S. Department of Energy, USDOE AU-13, DE-HS0000073

Subjects
Radiation, business.industry, [SDV]Life Sciences [q-bio], Imaging phantom, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Skull, 0302 clinical medicine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, medicine, Calibration, Environmental science, Skull bone, Nuclear medicine, business, Instrumentation
Abstract

International audience; In 2011 a measurement intercomparison was launched by EURADOS WG7, with the objective of providing the participants with the tools to calibrate their detection systems for detection of 241Am in the skull bone, and evaluate the variability due to the used of the different calibration phantoms. Three skull phantoms were used in this intercomparison the USTUR Case 0102 skull phantom, the BfS skull phantom and the CSR skull phantom. Very good agreement was found between the results of the twelve participating laboratories, with relative deviations of less than 15% for the BfS phantom and less than 17% for the USTUR phantom when measurement efficiency in defined positions was compared. However, the phantoms' measured absolute 241Am activities showed discrepancies of up to a factor of 3.4. This is mainly due to the physical differences between the standard calibration phantoms used by the participants and those used in this intercomparison exercise. © 2015 Elsevier Ltd. All rights reserved.

Published
2015

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