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1. Erratum to: The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs

Author: D. S. Akerib, C. W. Akerlof, D. Yu. Akimov, A. Alquahtani, S. K. Alsum, T. J. Anderson, N. Angelides, H. M. Araújo, A. Arbuckle, J. E. Armstrong, M. Arthurs, H. Auyeung, S. Aviles, X. Bai, A. J. Bailey, J. Balajthy, S. Balashov, J. Bang, M. J. Barry, D. Bauer, P. Bauer, A. Baxter, J. Belle, P. Beltrame, J. Bensinger, T. Benson, E. P. Bernard, A. Bernstein, A. Bhatti, A. Biekert, T. P. Biesiadzinski, H. J. Birch, B. Birrittella, K. E. Boast, A. I. Bolozdynya, E. M. Boulton, B. Boxer, R. Bramante, S. Branson, P. Brás, M. Breidenbach, C. A. J. Brew, J. H. Buckley, V. V. Bugaev, R. Bunker, S. Burdin, J. K. Busenitz, R. Cabrita, J. S. Campbell, C. Carels, D. L. Carlsmith, B. Carlson, M. C. Carmona-Benitez, M. Cascella, C. Chan, J. J. Cherwinka, A. A. Chiller, C. Chiller, N. I. Chott, A. Cole, J. Coleman, D. Colling, R. A. Conley, A. Cottle, R. Coughlen, G. Cox, W. W. Craddock, D. Curran, A. Currie, J. E. Cutter, J. P. da Cunha, C. E. Dahl, S. Dardin, S. Dasu, J. Davis, T. J. R. Davison, L. de Viveiros, N. Decheine, A. Dobi, J. E. Y. Dobson, E. Druszkiewicz, A. Dushkin, T. K. Edberg, W. R. Edwards, B. N. Edwards, J. Edwards, M. M. Elnimr, W. T. Emmet, S. R. Eriksen, C. H. Faham, A. Fan, S. Fayer, S. Fiorucci, H. Flaecher, I. M. Fogarty Florang, P. Ford, V. B. Francis, E. D. Fraser, F. Froborg, T. Fruth, R. J. Gaitskell, N. J. Gantos, D. Garcia, V. M. Gehman, R. Gelfand, J. Genovesi, R. M. Gerhard, C. Ghag, E. Gibson, M. G. D. Gilchriese, S. Gokhale, B. Gomber, T. G. Gonda, A. Greenall, S. Greenwood, G. Gregerson, M. G. D. van der Grinten, C. B. Gwilliam, C. R. Hall, D. Hamilton, S. Hans, K. Hanzel, T. Harrington, A. Harrison, J. Harrison, C. Hasselkus, S. J. Haselschwardt, D. Hemer, S. A. Hertel, J. Heise, S. Hillbrand, O. Hitchcock, C. Hjemfelt, M. D. Hoff, B. Holbrook, E. Holtom, J. Y-K. Hor, M. Horn, D. Q. Huang, T. W. Hurteau, C. M. Ignarra, M. N. Irving, R. G. Jacobsen, O. Jahangir, S. N. Jeffery, W. Ji, M. Johnson, J. Johnson, P. Johnson, W. G. Jones, A. C. Kaboth, A. Kamaha, K. Kamdin, V. Kasey, K. Kazkaz, J. Keefner, D. Khaitan, M. Khaleeq, A. Khazov, A. V. Khromov, I. Khurana, Y. D. Kim, W. T. Kim, C. D. Kocher, D. Kodroff, A. M. Konovalov, L. Korley, E. V. Korolkova, M. Koyuncu, J. Kras, H. Kraus, S. W. Kravitz, H. J. Krebs, L. Kreczko, B. Krikler, V. A. Kudryavtsev, A. V. Kumpan, S. Kyre, A. R. Lambert, B. Landerud, N. A. Larsen, A. Laundrie, E. A. Leason, H. S. Lee, J. Lee, C. Lee, B. G. Lenardo, D. S. Leonard, R. Leonard, K. T. Lesko, C. Levy, J. Li, Y. Liu, J. Liao, F.-T. Liao, J. Lin, A. Lindote, R. Linehan, W. H. Lippincott, R. Liu, X. Liu, C. Loniewski, M. I. Lopes, E. Lopez-Asamar, B. López Paredes, W. Lorenzon, D. Lucero, S. Luitz, J. M. Lyle, C. Lynch, P. A. Majewski, J. Makkinje, D. C. Malling, A. Manalaysay, L. Manenti, R. L. Mannino, N. Marangou, D. J. Markley, P. MarrLaundrie, T. J. Martin, M. F. Marzioni, C. Maupin, C. T. McConnell, D. N. McKinsey, J. McLaughlin, D.-M. Mei, Y. Meng, E. H. Miller, Z. J. Minaker, E. Mizrachi, J. Mock, D. Molash, A. Monte, M. E. Monzani, J. A. Morad, E. Morrison, B. J. Mount, A. St. J. Murphy, D. Naim, A. Naylor, C. Nedlik, C. Nehrkorn, H. N. Nelson, J. Nesbit, F. Neves, J. A. Nikkel, J. A. Nikoleyczik, A. Nilima, J. O’Dell, H. Oh, F. G. O’Neill, K. O’Sullivan, I. Olcina, M. A. Olevitch, K. C. Oliver-Mallory, L. Oxborough, A. Pagac, D. Pagenkopf, S. Pal, K. J. Palladino, V. M. Palmaccio, J. Palmer, M. Pangilinan, N. Parveen, S. J. Patton, E. K. Pease, B. P. Penning, G. Pereira, C. Pereira, I. B. Peterson, A. Piepke, S. Pierson, S. Powell, R. M. Preece, K. Pushkin, Y. Qie, M. Racine, B. N. Ratcliff, J. Reichenbacher, L. Reichhart, C. A. Rhyne, A. Richards, Q. Riffard, G. R. C. Rischbieter, J. P. Rodrigues, H. J. Rose, R. Rosero, P. Rossiter, R. Rucinski, G. Rutherford, J. S. Saba, L. Sabarots, D. Santone, M. Sarychev, A. B. M. R. Sazzad, R. W. Schnee, M. Schubnell, P. R. Scovell, M. Severson, D. Seymour, S. Shaw, G. W. Shutt, T. A. Shutt, J. J. Silk, C. Silva, K. Skarpaas, W. Skulski, A. R. Smith, R. J. Smith, R. E. Smith, J. So, M. Solmaz, V. N. Solovov, P. Sorensen, V. V. Sosnovtsev, I. Stancu, M. R. Stark, S. Stephenson, N. Stern, A. Stevens, T. M. Stiegler, K. Stifter, R. Studley, T. J. Sumner, K. Sundarnath, P. Sutcliffe, N. Swanson, M. Szydagis, M. Tan, W. C. Taylor, R. Taylor, D. J. Taylor, D. Temples, B. P. Tennyson, P. A. Terman, K. J. Thomas, J. A. Thomson, D. R. Tiedt, M. Timalsina, W. H. To, A. Tomás, T. E. Tope, M. Tripathi, D. R. Tronstad, C. E. Tull, W. Turner, L. Tvrznikova, M. Utes, U. Utku, S. Uvarov, J. Va’vra, A. Vacheret, A. Vaitkus, J. R. Verbus, T. Vietanen, E. Voirin, C. O. Vuosalo, S. Walcott, W. L. Waldron, K. Walker, J. J. Wang, R. Wang, L. Wang, W. Wang, Y. Wang, J. R. Watson, J. Migneault, S. Weatherly, R. C. Webb, W.-Z. Wei, M. While, R. G. White, J. T. White, D. T. White, T. J. Whitis, W. J. Wisniewski, K. Wilson, M. S. Witherell, F. L. H. Wolfs, J. D. Wolfs, D. Woodward, S. D. Worm, X. Xiang, Q. Xiao, J. Xu, M. Yeh, J. Yin, I. Young, C. Zhang, and P. Zarzhitsky
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published: 2022
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2. The LUX-ZEPLIN (LZ) radioactivity and cleanliness control programs

Author: D. S. Akerib, C. W. Akerlof, D. Yu. Akimov, A. Alquahtani, S. K. Alsum, T. J. Anderson, N. Angelides, H. M. Araújo, A. Arbuckle, J. E. Armstrong, M. Arthurs, H. Auyeung, S. Aviles, X. Bai, A. J. Bailey, J. Balajthy, S. Balashov, J. Bang, M. J. Barry, D. Bauer, P. Bauer, A. Baxter, J. Belle, P. Beltrame, J. Bensinger, T. Benson, E. P. Bernard, A. Bernstein, A. Bhatti, A. Biekert, T. P. Biesiadzinski, H. J. Birch, B. Birrittella, K. E. Boast, A. I. Bolozdynya, E. M. Boulton, B. Boxer, R. Bramante, S. Branson, P. Brás, M. Breidenbach, C. A. J. Brew, J. H. Buckley, V. V. Bugaev, R. Bunker, S. Burdin, J. K. Busenitz, R. Cabrita, J. S. Campbell, C. Carels, D. L. Carlsmith, B. Carlson, M. C. Carmona-Benitez, M. Cascella, C. Chan, J. J. Cherwinka, A. A. Chiller, C. Chiller, N. I. Chott, A. Cole, J. Coleman, D. Colling, R. A. Conley, A. Cottle, R. Coughlen, G. Cox, W. W. Craddock, D. Curran, A. Currie, J. E. Cutter, J. P. da Cunha, C. E. Dahl, S. Dardin, S. Dasu, J. Davis, T. J. R. Davison, L. de Viveiros, N. Decheine, A. Dobi, J. E. Y. Dobson, E. Druszkiewicz, A. Dushkin, T. K. Edberg, W. R. Edwards, B. N. Edwards, J. Edwards, M. M. Elnimr, W. T. Emmet, S. R. Eriksen, C. H. Faham, A. Fan, S. Fayer, S. Fiorucci, H. Flaecher, I. M. Fogarty Florang, P. Ford, V. B. Francis, E. D. Fraser, F. Froborg, T. Fruth, R. J. Gaitskell, N. J. Gantos, D. Garcia, V. M. Gehman, R. Gelfand, J. Genovesi, R. M. Gerhard, C. Ghag, E. Gibson, M. G. D. Gilchriese, S. Gokhale, B. Gomber, T. G. Gonda, A. Greenall, S. Greenwood, G. Gregerson, M. G. D. van der Grinten, C. B. Gwilliam, C. R. Hall, D. Hamilton, S. Hans, K. Hanzel, T. Harrington, A. Harrison, J. Harrison, C. Hasselkus, S. J. Haselschwardt, D. Hemer, S. A. Hertel, J. Heise, S. Hillbrand, O. Hitchcock, C. Hjemfelt, M. D. Hoff, B. Holbrook, E. Holtom, J. Y-K. Hor, M. Horn, D. Q. Huang, T. W. Hurteau, C. M. Ignarra, M. N. Irving, R. G. Jacobsen, O. Jahangir, S. N. Jeffery, W. Ji, M. Johnson, J. Johnson, P. Johnson, W. G. Jones, A. C. Kaboth, A. Kamaha, K. Kamdin, V. Kasey, K. Kazkaz, J. Keefner, D. Khaitan, M. Khaleeq, A. Khazov, A. V. Khromov, I. Khurana, Y. D. Kim, W. T. Kim, C. D. Kocher, D. Kodroff, A. M. Konovalov, L. Korley, E. V. Korolkova, M. Koyuncu, J. Kras, H. Kraus, S. W. Kravitz, H. J. Krebs, L. Kreczko, B. Krikler, V. A. Kudryavtsev, A. V. Kumpan, S. Kyre, A. R. Lambert, B. Landerud, N. A. Larsen, A. Laundrie, E. A. Leason, H. S. Lee, J. Lee, C. Lee, B. G. Lenardo, D. S. Leonard, R. Leonard, K. T. Lesko, C. Levy, J. Li, Y. Liu, J. Liao, F.-T. Liao, J. Lin, A. Lindote, R. Linehan, W. H. Lippincott, R. Liu, X. Liu, C. Loniewski, M. I. Lopes, E. Lopez-Asamar, B. López Paredes, W. Lorenzon, D. Lucero, S. Luitz, J. M. Lyle, C. Lynch, P. A. Majewski, J. Makkinje, D. C. Malling, A. Manalaysay, L. Manenti, R. L. Mannino, N. Marangou, D. J. Markley, P. MarrLaundrie, T. J. Martin, M. F. Marzioni, C. Maupin, C. T. McConnell, D. N. McKinsey, J. McLaughlin, D.-M. Mei, Y. Meng, E. H. Miller, Z. J. Minaker, E. Mizrachi, J. Mock, D. Molash, A. Monte, M. E. Monzani, J. A. Morad, E. Morrison, B. J. Mount, A. St. J. Murphy, D. Naim, A. Naylor, C. Nedlik, C. Nehrkorn, H. N. Nelson, J. Nesbit, F. Neves, J. A. Nikkel, J. A. Nikoleyczik, A. Nilima, J. O’Dell, H. Oh, F. G. O’Neill, K. O’Sullivan, I. Olcina, M. A. Olevitch, K. C. Oliver-Mallory, L. Oxborough, A. Pagac, D. Pagenkopf, S. Pal, K. J. Palladino, V. M. Palmaccio, J. Palmer, M. Pangilinan, N. Parveen, S. J. Patton, E. K. Pease, B. P. Penning, G. Pereira, C. Pereira, I. B. Peterson, A. Piepke, S. Pierson, S. Powell, R. M. Preece, K. Pushkin, Y. Qie, M. Racine, B. N. Ratcliff, J. Reichenbacher, L. Reichhart, C. A. Rhyne, A. Richards, Q. Riffard, G. R. C. Rischbieter, J. P. Rodrigues, H. J. Rose, R. Rosero, P. Rossiter, R. Rucinski, G. Rutherford, J. S. Saba, L. Sabarots, D. Santone, M. Sarychev, A. B. M. R. Sazzad, R. W. Schnee, M. Schubnell, P. R. Scovell, M. Severson, D. Seymour, S. Shaw, G. W. Shutt, T. A. Shutt, J. J. Silk, C. Silva, K. Skarpaas, W. Skulski, A. R. Smith, R. J. Smith, R. E. Smith, J. So, M. Solmaz, V. N. Solovov, P. Sorensen, V. V. Sosnovtsev, I. Stancu, M. R. Stark, S. Stephenson, N. Stern, A. Stevens, T. M. Stiegler, K. Stifter, R. Studley, T. J. Sumner, K. Sundarnath, P. Sutcliffe, N. Swanson, M. Szydagis, M. Tan, W. C. Taylor, R. Taylor, D. J. Taylor, D. Temples, B. P. Tennyson, P. A. Terman, K. J. Thomas, J. A. Thomson, D. R. Tiedt, M. Timalsina, W. H. To, A. Tomás, T. E. Tope, M. Tripathi, D. R. Tronstad, C. E. Tull, W. Turner, L. Tvrznikova, M. Utes, U. Utku, S. Uvarov, J. Va’vra, A. Vacheret, A. Vaitkus, J. R. Verbus, T. Vietanen, E. Voirin, C. O. Vuosalo, S. Walcott, W. L. Waldron, K. Walker, J. J. Wang, R. Wang, L. Wang, W. Wang, Y. Wang, J. R. Watson, J. Migneault, S. Weatherly, R. C. Webb, W.-Z. Wei, M. While, R. G. White, J. T. White, D. T. White, T. J. Whitis, W. J. Wisniewski, K. Wilson, M. S. Witherell, F. L. H. Wolfs, J. D. Wolfs, D. Woodward, S. D. Worm, X. Xiang, Q. Xiao, J. Xu, M. Yeh, J. Yin, I. Young, C. Zhang, and P. Zarzhitsky
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract LUX-ZEPLIN (LZ) is a second-generation direct dark matter experiment with spin-independent WIMP-nucleon scattering sensitivity above $${1.4 \times 10^{-48}}\, {\hbox {cm}}^{2}$$ 1.4 × 10 - 48 cm 2 for a WIMP mass of $${40}\, \hbox {GeV}/{\hbox {c}}^{2}$$ 40 GeV / c 2 and a $${1000}\, \hbox {days}$$ 1000 days exposure. LZ achieves this sensitivity through a combination of a large $${5.6}\, \hbox {t}$$ 5.6 t fiducial volume, active inner and outer veto systems, and radio-pure construction using materials with inherently low radioactivity content. The LZ collaboration performed an extensive radioassay campaign over a period of six years to inform material selection for construction and provide an input to the experimental background model against which any possible signal excess may be evaluated. The campaign and its results are described in this paper. We present assays of dust and radon daughters depositing on the surface of components as well as cleanliness controls necessary to maintain background expectations through detector construction and assembly. Finally, examples from the campaign to highlight fixed contaminant radioassays for the LZ photomultiplier tubes, quality control and quality assurance procedures through fabrication, radon emanation measurements of major sub-systems, and bespoke detector systems to assay scintillator are presented.
Published: 2020
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3. Constraints on effective field theory couplings using 311.2 days of LUX data

Author: A. St. J. Murphy, Adam Bernstein, T. P. Biesiadzinski, M.I. Lopes, Jilei Xu, C. Nehrkorn, S. Alsum, M. Horn, P. A. Terman, A. Fan, J. T. White, P. Rossiter, Sergey Burdin, A. Baxter, S. J. Haselschwardt, R. Taylor, T. J. Whitis, A. Manalaysay, D. Byram, Antonin Vacheret, B. G. Lenardo, Q. Riffard, N. Swanson, P. Brás, K. T. Lesko, V. Velan, Ethan Bernard, A. Nilima, Matthew Szydagis, T. J. Sumner, S. Shaw, R. G. Jacobsen, K. Palladino, P. Sorensen, D. Khaitan, R. C. Webb, L. de Viveiros, J. A. Morad, M. Solmaz, B. P. Tennyson, O. Jahangir, U. Utku, W. C. Taylor, X. Bai, K. Kazkaz, E. Leason, J. Bang, H. N. Nelson, Henrique Araujo, W. Ji, L. Tvrznikova, V. A. Kudryavtsev, F. Neves, D. R. Tiedt, J. Balajthy, B. Boxer, C. M. Ignarra, A. Lindote, R. L. Mannino, S. A. Hertel, S. Fiorucci, Carl Gwilliam, T. A. Shutt, W. H. To, D. S. Akerib, E. Druszkiewicz, V. N. Solovov, C. R. Hall, K. C. Oliver-Mallory, D. Woodward, D. J. Taylor, Chao Zhang, D. P. Hogan, M. C. Carmona-Benitez, M. G. D. Gilchriese, C. Rhyne, N. Marangou, Elena Korolkova, J. Liao, G. R. C. Rischbieter, R. J. Gaitskell, Dongming Mei, F. L. H. Wolfs, E. M. Boulton, K. Kamdin, X. Xiang, J. Lin, Daniel McKinsey, A. Naylor, J. E. Cutter, D. Q. Huang, C. Ghag, Michael S. Witherell, Catarina Silva, C. Chan, A. Vaitkus, S. Kravitz, and Science and Technology Facilities Council (STFC)
Subjects: Cosmology and Nongalactic Astrophysics (astro-ph.CO), SPECTROSCOPIC SURVEY, Nuclear Theory, FOS: Physical sciences, Astronomy & Astrophysics, Atomic, 7. Clean energy, 01 natural sciences, Physics, Particles & Fields, Particle and Plasma Physics, 0103 physical sciences, Effective field theory, DARK-MATTER, Order (group theory), Nuclear, 010306 general physics, Mathematical physics, Physics, Quantum Physics, Science & Technology, 010308 nuclear & particles physics, Astrophysics::Instrumentation and Methods for Astrophysics, Molecular, Nuclear & Particles Physics, Physical Sciences, astro-ph.CO, Astronomical and Space Sciences, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: We report here the results of an Effective Field Theory (EFT) WIMP search analysis using LUX data. We build upon previous LUX analyses by extending the search window to include nuclear recoil energies up to $\sim$180 keV$_{nr}$, requiring a reassessment of data quality cuts and background models. In order to use a binned Profile Likelihood statistical framework, the development of new analysis techniques to account for higher-energy backgrounds was required. With a 3.14$\times10^4$ kg$\cdot$day exposure using data collected between 2014 and 2016, we set 90\% C.L. exclusion limits on non-relativistic EFT WIMP couplings to neutrons and protons, providing the most stringent constraints on a significant fraction of the possible EFT WIMP interactions. Additionally, we report world-leading exclusion limits on inelastic EFT WIMP-nucleon recoils., 19 Pages, 10 Figures, 4 Table
Published: 2021
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4. Discrimination of electronic recoils from nuclear recoils in two-phase xenon time projection chambers

Author: F. L. H. Wolfs, E. M. Boulton, T. A. Shutt, Ethan Bernard, P. Brás, Kareem Kazkaz, T. P. Biesiadzinski, J. T. White, Henrique Araujo, L. Tvrznikova, C. R. Hall, S. Uvarov, X. Bai, E. Druszkiewicz, M. Horn, M. G. D. Gilchriese, Carl Gwilliam, D. J. Taylor, Daniel McKinsey, E. Leason, Q. Riffard, V. A. Kudryavtsev, C. M. Ignarra, Catarina Silva, S. Alsum, A. Naylor, Robert A. Taylor, P. Rossiter, M. Moongweluwan, C. Chan, Chao Zhang, S. Kravitz, D. Q. Huang, T. J. Whitis, Elena Korolkova, B. G. Lenardo, J. A. Morad, G. R. C. Rischbieter, T. J. Sumner, K. T. Lesko, N. Marangou, S. Shaw, M. Solmaz, M. S. Witherell, O. Jahangir, P. A. Terman, Dongming Mei, D. R. Tiedt, Antonin Vacheret, D. S. Akerib, J. Lin, P. Sorensen, V. Velan, J. E. Cutter, A. St. J. Murphy, F. Neves, Adam Bernstein, B. P. Tennyson, D. Khaitan, M.I. Lopes, C. Ghag, K. C. Oliver-Mallory, J. Liao, D. P. Hogan, A. Fan, K. J. Palladino, C. Rhyne, R. J. Gaitskell, E. K. Pease, V. N. Solovov, R. C. Webb, L. de Viveiros, R. L. Mannino, S. Fiorucci, W. H. To, D. Woodward, W. C. Taylor, J. Balajthy, Jilei Xu, C. Nehrkorn, U. Utku, D. Byram, B. Boxer, Matthew Szydagis, S. A. Hertel, Sergey Burdin, A. Baxter, A. Manalaysay, A. Lindote, M. C. Carmona-Benitez, K. Kamdin, S. J. Haselschwardt, H. N. Nelson, R. G. Jacobsen, W. Ji, A. Nilima, and Science and Technology Facilities Council (STFC)
Subjects: Photon, Large Underground Xenon experiment, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, Massive particle, FOS: Physical sciences, chemistry.chemical_element, Astronomy & Astrophysics, nucl-ex, 01 natural sciences, Atomic, Physics, Particles & Fields, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), Recoil, Xenon, Particle and Plasma Physics, Electric field, 0103 physical sciences, Nuclear, Nuclear Experiment (nucl-ex), 010306 general physics, Nuclear Experiment, physics.ins-det, Physics, Quantum Physics, Science & Technology, 010308 nuclear & particles physics, hep-ex, Drift field, Molecular, Instrumentation and Detectors (physics.ins-det), Recoil energy, Nuclear & Particles Physics, chemistry, Physical Sciences, Astronomical and Space Sciences
Abstract: We present a comprehensive analysis of electronic recoil vs. nuclear recoil discrimination in liquid/gas xenon time projection chambers, using calibration data from the 2013 and 2014-16 runs of the Large Underground Xenon (LUX) experiment. We observe strong charge-to-light discrimination enhancement with increased event energy. For events with S1 = 120 detected photons, i.e. equivalent to a nuclear recoil energy of $\sim$100 keV, we observe an electronic recoil background acceptance of $, 29 pages, 33 figures; minor typos corrected, references updated
Published: 2020
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5. Search for two neutrino double electron capture of 124Xe and 126Xe in the full exposure of the LUX detector

Author: E. M. Boulton, A. Naylor, L. Tvrznikova, P. Brás, T. J. Sumner, A. Manalaysay, A. Lindote, J. A. Morad, Jilei Xu, R. L. Mannino, D. Q. Huang, C. Nehrkorn, M. C. Carmona-Benitez, Carl Gwilliam, Ethan Bernard, Catarina Silva, W. C. Taylor, J. Balajthy, K. Kamdin, Chao Zhang, J. Liao, W. H. To, D. R. Tiedt, S. Uvarov, D. Woodward, A. Fan, Henrique Araujo, J. Lin, D. M. Mei, S. J. Haselschwardt, N. Marangou, Q. Riffard, D. S. Akerib, V. A. Kudryavtsev, Sergey Burdin, D. J. Taylor, T. A. Shutt, C. Rhyne, S. A. Hertel, E. Druszkiewicz, M. Horn, A. Baxter, R. J. Gaitskell, C. Chan, S. Kravitz, C. R. Hall, C. M. Ignarra, K. J. Palladino, U. Utku, D. Byram, A. St. J. Murphy, Adam Bernstein, G. R. C. Rischbieter, Mani Tripathi, M.I. Lopes, Elena Korolkova, M. G. D. Gilchriese, B. G. Lenardo, E. K. Pease, H. N. Nelson, S. Fiorucci, B. Boxer, L. de Viveiros, V. N. Solovov, Daniel McKinsey, S. Alsum, M. Moongweluwan, F. L. H. Wolfs, P. Sorensen, M. Solmaz, M. F. Marzioni, K. C. Oliver-Mallory, R. C. Webb, C. Ghag, J. T. White, D. P. Hogan, D. Khaitan, B. P. Tennyson, P. Rossiter, Matthew Szydagis, Robert A. Taylor, F. Neves, J. E. Cutter, T. J. Whitis, P. A. Terman, Antonin Vacheret, S. Shaw, M. S. Witherell, O. Jahangir, X. Bai, K. T. Lesko, E. Leason, R. G. Jacobsen, Kareem Kazkaz, T. P. Biesiadzinski, W. Ji, A. Nilima, V. Velan, and Science and Technology Facilities Council (STFC)
Subjects: COLLISIONS, Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Electron capture, Analytical chemistry, FOS: Physical sciences, nucl-ex, Atomic, 01 natural sciences, 7. Clean energy, Physics, Particles & Fields, HEAVY-IONS, LIMITS, Particle and Plasma Physics, rare decays, 0103 physical sciences, Nuclear, Nuclear Experiment (nucl-ex), xenon detectors, 010306 general physics, Nuclear Experiment, physics.ins-det, Physics, Science & Technology, dark matter detectors, 010308 nuclear & particles physics, Molecular, Instrumentation and Detectors (physics.ins-det), Nuclear & Particles Physics, 3. Good health, Physics, Nuclear, double electron capture, Physical Sciences, 0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics, Neutrino
Abstract: Two-neutrino double electron capture is a process allowed in the Standard Model of Particle Physics. This rare decay has been observed in $^{78}$Kr, $^{130}$Ba and more recently in $^{124}$Xe. In this publication we report on the search for this process in $^{124}$Xe and $^{126}$Xe using the full exposure of the Large Underground Xenon (LUX) experiment, in a total of of 27769.5~kg-days. No evidence of a signal was observed, allowing us to set 90\% C.L. lower limits for the half-lives of these decays of $2.0\times10^{21}$~years for $^{124}$Xe and $1.9\times10^{21}$~years for $^{126}$Xe., 8 pages, 3 figures
Published: 2020
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6. Projected sensitivity of the LUX-ZEPLIN experiment to the 0νββ decay of Xe136

Author: Richard Rosero, D. R. Tronstad, David Leonard, X. Bai, J. Johnson, X. Liu, J. Busenitz, P. Brás, C. Rhyne, A. Cole, R. J. Gaitskell, R. Linehan, Eli Gibson, C. Levy, Sergey Burdin, R. C. Webb, A. Baxter, L. de Viveiros, A. Alqahtani, A. Monte, C. Ghag, N. Angelides, P. Sorensen, S. Gokhale, S. Shaw, Catarina Silva, J. Palmer, B. Lopez Paredes, T. J. Sumner, N. Marangou, A. Manalaysay, K. E. Boast, O. Jahangir, R. W. Schnee, S. Pal, M. E. Monzani, Yue Meng, D. Naim, I. Stancu, J. Liao, J. J. Wang, K. O’Sullivan, V. Bugaev, N. I. Chott, A. Khazov, P. Zarzhitsky, B. J. Mount, T. A. Shutt, Matthew Szydagis, J. Lin, H. N. Nelson, K. C. Oliver-Mallory, Wolfgang Lorenzon, Ross G. White, J.J. Silk, J. R. Bensinger, E. Leason, Benjamin Krikler, M. G. D. Gilchriese, E. Druszkiewicz, Laura Manenti, J. E. Y. Dobson, C. Carels, E. Mizrachi, C. Chan, Henrique Araujo, J. A. Morad, L. Kreczko, J. R. Watson, F.-T. Liao, A. Vaitkus, S. Kravitz, W. C. Taylor, P. Rossiter, H. J. Birch, D. Khaitan, K. Stifter, A. Kamaha, J. Bang, J. A. Nikoleyczik, D. Seymour, W. Turner, U. Utku, E. D. Fraser, Mani Tripathi, K. T. Lesko, C. Nedlik, A. Biekert, J. Balajthy, V. A. Kudryavtsev, S. Fiorucci, A. C. Kaboth, J. McLaughlin, C. M. Ignarra, C. R. Hall, F. L. H. Wolfs, R. Cabrita, Kareem Kazkaz, G. Rutherford, D. R. Tiedt, A. Harrison, M. Horn, J. Li, T. P. Biesiadzinski, C. D. Kocher, M. G. D. van der Grinten, K. J. Palladino, M. F. Marzioni, M. C. Carmona-Benitez, J. Kras, Michele Cascella, Carl W. Akerlof, H. Kraus, C. E. Dahl, T. Fruth, T. J. Anderson, A. Lindote, J. M. Lyle, Jilei Xu, B. Boxer, C. Nehrkorn, A. B.M.R. Sazzad, A. Tomás, E. K. Pease, Juhyeong Lee, Michael Schubnell, D. S. Akerib, L. Korley, K. Kamdin, S. Balashov, Ethan Bernard, P. Majewski, W. H. Lippincott, V. N. Solovov, X. Xiang, Daniel McKinsey, N. Parveen, Minfang Yeh, A. St. J. Murphy, M. Solmaz, Adam Bernstein, Robert A. Taylor, E. Morrison, D. Woodward, A. Naylor, T. J. Whitis, S. J. Haselschwardt, D. Q. Huang, M.I. Lopes, N. Swanson, W. Wang, P. A. Terman, S. R. Eriksen, R. L. Mannino, Antonin Vacheret, M. Arthurs, S. Luitz, G. Pereira, Richard J. Smith, T. K. Edberg, Q. Riffard, D. Temples, K. Pushkin, J. E. Armstrong, J. H. Buckley, J. Genovesi, M. Tan, E. H. Miller, A. Cottle, I. Olcina, A. Bhatti, S. A. Hertel, C. Loniewski, Elena Korolkova, A. Stevens, G. R. C. Rischbieter, F. Neves, Bjoern Penning, M. Timalsina, L. Tvrznikova, Henning Flaecher, S. Alsum, I. Khurana, J. Y.K. Hor, J. E. Cutter, J. Reichenbacher, W. Ji, A. Fan, Duncan Carlsmith, D. Santone, A. Nilima, and R. Liu
Subjects: Physics, 010308 nuclear & particles physics, Active volume, 0103 physical sciences, Analytical chemistry, 010306 general physics, 01 natural sciences, Sensitivity (electronics)
Abstract: Author(s): Akerib, DS; Akerlof, CW; Alqahtani, A; Alsum, SK; Anderson, TJ; Angelides, N; Araujo, HM; Armstrong, JE; Arthurs, M; Bai, X; Balajthy, J; Balashov, S; Bang, J; Baxter, A; Bensinger, J; Bernard, EP; Bernstein, A; Bhatti, A; Biekert, A; Biesiadzinski, TP; Birch, HJ; Boast, KE; Boxer, B; Bras, P; Buckley, JH; Bugaev, VV; Burdin, S; Busenitz, JK; Cabrita, R; Carels, C; Carlsmith, DL; Carmona-Benitez, MC; Cascella, M; Chan, C; Chott, NI; Cole, A; Cottle, A; Cutter, JE; Dahl, CE; De Viveiros, L; Dobson, JEY; Druszkiewicz, E; Edberg, TK; Eriksen, SR; Fan, A; Fiorucci, S; Flaecher, H; Fraser, ED; Fruth, T; Gaitskell, RJ; Genovesi, J; Ghag, C; Gibson, E; Gilchriese, MGD; Gokhale, S; Van Der Grinten, MGD; Hall, CR; Harrison, A; Haselschwardt, SJ; Hertel, SA; Hor, JYK; Horn, M; Huang, DQ; Ignarra, CM; Jahangir, O; Ji, W; Johnson, J; Kaboth, AC; Kamaha, AC; Kamdin, K; Kazkaz, K; Khaitan, D; Khazov, A; Khurana, I; Kocher, CD; Korley, L; Korolkova, EV; Kras, J; Kraus, H; Kravitz, S; Kreczko, L; Krikler, B; Kudryavtsev, VA; Leason, EA; Lee, J | Abstract: The LUX-ZEPLIN (LZ) experiment will enable a neutrinoless double β decay search in parallel to the main science goal of discovering dark matter particle interactions. We report the expected LZ sensitivity to Xe136 neutrinoless double β decay, taking advantage of the significant (g600 kg) Xe136 mass contained within the active volume of LZ without isotopic enrichment. After 1000 live-days, the median exclusion sensitivity to the half-life of Xe136 is projected to be 1.06×1026 years (90% confidence level), similar to existing constraints. We also report the expected sensitivity of a possible subsequent dedicated exposure using 90% enrichment with Xe136 at 1.06×1027 years.
Published: 2020
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7. Investigation of background electron emission in the LUX detector

Author: D. J. Taylor, M. G. D. Gilchriese, V. Velan, U. Utku, A. Manalaysay, A. Fan, S. Shaw, L. Tvrznikova, P. A. Terman, T. J. Sumner, J. T. White, Ethan Bernard, H. N. Nelson, W. H. To, D. Woodward, W. C. Taylor, J. Balajthy, B. G. Lenardo, M. S. Witherell, O. Jahangir, P. Brás, Robert A. Taylor, Q. Riffard, Carl Gwilliam, Daniel McKinsey, R. G. Jacobsen, Jilei Xu, C. Nehrkorn, T. J. Whitis, M. Solmaz, X. Bai, D. Khaitan, S. Alsum, M. C. Carmona-Benitez, S. A. Hertel, W. Ji, K. Kamdin, E. Druszkiewicz, M. Moongweluwan, Antonin Vacheret, F. L. H. Wolfs, P. Rossiter, K. J. Palladino, E. M. Boulton, R. L. Mannino, Elena Korolkova, G. R. C. Rischbieter, K. C. Oliver-Mallory, S. J. Haselschwardt, D. Byram, T. A. Shutt, J. A. Morad, J. Lin, D. R. Tiedt, Henrique Araujo, E. K. Pease, D. P. Hogan, B. Boxer, K. T. Lesko, V. N. Solovov, E. Leason, C. R. Hall, Matthew Szydagis, D. S. Akerib, S. Uvarov, R. C. Webb, M. Horn, L. de Viveiros, A. St. J. Murphy, P. Sorensen, Adam Bernstein, B. P. Tennyson, A. Naylor, M.I. Lopes, D. Q. Huang, Kareem Kazkaz, V. A. Kudryavtsev, C. M. Ignarra, T. P. Biesiadzinski, J. Liao, Sergey Burdin, C. Rhyne, A. Baxter, R. J. Gaitskell, A. Lindote, S. Fiorucci, J. E. Cutter, Chao Zhang, C. Ghag, N. Marangou, F. Neves, Dongming Mei, Catarina Silva, C. Chan, S. Kravitz, A. Nilima, and Science and Technology Facilities Council (STFC)
Subjects: Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, Dark matter, FOS: Physical sciences, chemistry.chemical_element, Electron, Photoionization, Astrophysics::Cosmology and Extragalactic Astrophysics, Astronomy & Astrophysics, Atomic, 01 natural sciences, Physics, Particles & Fields, ENERGY, XENON, Particle and Plasma Physics, Xenon, DEPENDENCE, Impurity, LIQUID ARGON, 0103 physical sciences, Nuclear, FIELD, 010306 general physics, physics.ins-det, Physics, Quantum Physics, Science & Technology, 010308 nuclear & particles physics, Detector, Molecular, Instrumentation and Detectors (physics.ins-det), Photoelectric effect, Nuclear & Particles Physics, STATE, KRYPTON, chemistry, Physical Sciences, Atomic physics, Luminescence, Astronomical and Space Sciences
Abstract: Dual-phase xenon detectors, as currently used in direct detection dark matter experiments, have observed elevated rates of background electron events in the low energy region. While this background negatively impacts detector performance in various ways, its origins have only been partially studied. In this paper we report a systematic investigation of the electron pathologies observed in the LUX dark matter experiment. We characterize different electron populations based on their emission intensities and their correlations with preceding energy depositions in the detector. By studying the background under different experimental conditions, we identified the leading emission mechanisms, including photoionization and the photoelectric effect induced by the xenon luminescence, delayed emission of electrons trapped under the liquid surface, capture and release of drifting electrons by impurities, and grid electron emission. We discuss how these backgrounds can be mitigated in LUX and future xenon-based dark matter experiments., 17 pages, 13 figures
Published: 2020
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8. Measurement of the Gamma Ray Background in the Davis Cavern at the Sanford Underground Research Facility

Author: A. Biekert, V. A. Kudryavtsev, M. G. D. van der Grinten, C. M. Ignarra, Henrique Araujo, D. Seymour, E. Leason, B. Boxer, A. Naylor, J. McLaughlin, J. Y.K. Hor, A. Murphy, J. E. Cutter, J. Reichenbacher, C. R. Hall, G. Pereira, M. Horn, C. D. Kocher, K. Pushkin, X. Bai, J. Johnson, D. Q. Huang, H. Kraus, C. Carels, X. Liu, J. M. Lyle, T. K. Edberg, A. Lindote, T. Fruth, M. C. Carmona-Benitez, Q. Riffard, L. Kreczko, D. Woodward, M. F. Marzioni, T.M. Stiegler, Juhyeong Lee, T. P. Biesiadzinski, A. Cottle, A. Tomás, S. Balashov, W.T. Kim, F. Neves, K. E. Boast, A. B.M.R. Sazzad, L. Korley, K. Kamdin, Murdock Gilchriese, David Leonard, Robert A. Taylor, Catarina Silva, C. E. Dahl, M. E. Monzani, A. Angelides, D. Temples, P. Brás, M. Solmaz, A. Manalaysay, D. Khaitan, P. Majewski, E. Morrison, T. J. Whitis, Matthew Szydagis, J. Genovesi, J.P. Rodrigues, J. Busenitz, Benjamin Krikler, A. Fan, C. Rhyne, R. J. Gaitskell, J. E. Armstrong, A. Stevens, Ethan Bernard, Bjoern Penning, Michael Schubnell, J. H. Buckley, Ross G. White, I. Stancu, L. Tvrznikova, P.R. Scovell, Daniel McKinsey, W. Ji, K. J. Palladino, I. Olcina, J. A. Morad, H. N. Nelson, N. Marangou, J. A. Nikoleyczik, R. L. Mannino, Michele Cascella, Sergey Burdin, A. Baxter, C. Nedlik, C. Ghag, P. Rossiter, C. Chan, M.I. Lopes, E. K. Pease, V. Bugaev, S. Kravitz, V. N. Solovov, S. Gokhale, S. Alsum, Julie Harrison, K. C. Oliver-Mallory, J. R. Watson, C. Levy, E. H. Miller, F.-T. Liao, S. Luitz, J. Lin, J. Yin, A. Piepke, S. Hans, J. Liao, S. J. Haselschwardt, F. L. H. Wolfs, A. Nilima, S. Uvarov, G. Rutherford, D. R. Tiedt, J. Kras, R. Linehan, Laura Manenti, K. T. Lesko, D. Naim, B. J. Mount, D. S. Akerib, T. A. Shutt, J. J. Wang, J. E. Y. Dobson, L.D. Viveiros, C. Loniewski, S. Shaw, Wolfgang Lorenzon, Elena Korolkova, H. Flaecher, M. Timalsina, O. Jahangir, P. Sorensen, Yue Meng, W.H. Lippincott, A. Cole, K. Stifter, S. Fiorucci, P. A. Terman, R. Liu, Richard Rosero, R. C. Webb, Antonin Vacheret, M. Arthurs, A. Khazov, J.J. Silk, W. C. Taylor, J. Balajthy, A. C. Kaboth, B.L. Paredes, R. W. Schnee, S. Pal, G.R.C. Rischbieter, C. Nehrkorn, S. A. Hertel, E. Druszkiewicz, U. Utku, Mani Tripathi, J. Li, Carl W. Akerlof, Duncan Carlsmith, and Science and Technology Facilities Council (STFC)
Subjects: Physics - Instrumentation and Detectors, Dark matter, FOS: Physical sciences, Flux, chemistry.chemical_element, Cosmic ray, Astronomy & Astrophysics, 01 natural sciences, Physics, Particles & Fields, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), Lead shielding, Xenon, Gamma spectroscopy, 0103 physical sciences, 0201 Astronomical and Space Sciences, 010306 general physics, Underground, physics.ins-det, Low background, Physics, Science & Technology, Radiation, 010308 nuclear & particles physics, hep-ex, Gamma rays, Gamma ray, Astronomy and Astrophysics, Instrumentation and Detectors (physics.ins-det), Nuclear & Particles Physics, chemistry, Physical Sciences, 0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics, Decay chain
Abstract: Deep underground environments are ideal for low background searches due to the attenuation of cosmic rays by passage through the earth. However, they are affected by backgrounds from $\gamma$-rays emitted by $^{40}$K and the $^{238}$U and $^{232}$Th decay chains in the surrounding rock. The LUX-ZEPLIN (LZ) experiment will search for dark matter particle interactions with a liquid xenon TPC located within the Davis campus at the Sanford Underground Research Facility, Lead, South Dakota, at the 4,850-foot level. In order to characterise the cavern background, in-situ $\gamma$-ray measurements were taken with a sodium iodide detector in various locations and with lead shielding. The integral count rates (0--3300~keV) varied from 596~Hz to 1355~Hz for unshielded measurements, corresponding to a total flux in the cavern of $1.9\pm0.4$~$\gamma~$cm$^{-2}$s$^{-1}$. The resulting activity in the walls of the cavern can be characterised as $220\pm60$~Bq/kg of $^{40}$K, $29\pm15$~Bq/kg of $^{238}$U, and $13\pm3$~Bq/kg of $^{232}$Th., Comment: 11 pages, 9 figures
Published: 2020
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9. Simulations of Events for the LUX-ZEPLIN (LZ) Dark Matter Experiment

Author: T. Fruth, D. Seymour, J. Lin, W. Ji, J. McLaughlin, J. Palmer, L. Tvrznikova, M. Tan, P. R. Scovell, J. Genovesi, Ethan Bernard, E. H. Miller, F. L. H. Wolfs, G. Rutherford, V. Bugaev, J. Kras, D. Woodward, B. Lopez Paredes, M. Solmaz, E. Morrison, A. Biekert, I. Stancu, A. Lindote, K. E. Boast, A. Fan, Kareem Kazkaz, Juhyeong Lee, I. Olcina, A. Bhatti, A. Alqahtani, M. G. D. Gilchriese, S. Balashov, D. Santone, C. Carels, A. Piepke, Ross G. White, A. Cottle, M. E. Monzani, F.-T. Liao, T. P. Biesiadzinski, C. Loniewski, J. Y.K. Hor, J. E. Cutter, J. Reichenbacher, M. G. D. van der Grinten, N. I. Chott, P. Zarzhitsky, Matthew Szydagis, C. Levy, Sergey Burdin, K. J. Palladino, P. Rossiter, Elena Korolkova, Laura Manenti, G. R. C. Rischbieter, A. Baxter, D. R. Tiedt, C. E. Dahl, B. Boxer, T. K. Edberg, S. A. Hertel, Q. Riffard, U. Utku, K. C. Oliver-Mallory, R. W. Schnee, S. Pal, G. Pereira, Richard J. Smith, Michele Cascella, David Leonard, E. Druszkiewicz, D. S. Akerib, Mani Tripathi, A. Nilima, Simon Fayer, M. Timalsina, E. K. Pease, D. Temples, K. Pushkin, N. Angelides, P. Majewski, M. C. Carmona-Benitez, T. J. Anderson, N. Marangou, J. Busenitz, W. H. Lippincott, Michael Schubnell, A. B.M.R. Sazzad, C. Rhyne, J. E. Armstrong, V. N. Solovov, A. Manalaysay, A. Khazov, J.J. Silk, A. St. J. Murphy, Adam Bernstein, A. Naylor, D. Naim, S. Shaw, J. Li, S. Luitz, S. Gokhale, A. Cole, R. J. Gaitskell, J. H. Buckley, L. Korley, N. Parveen, K. Kamdin, R. Linehan, Minfang Yeh, W. C. Taylor, D. Q. Huang, B. J. Mount, T. A. Shutt, Catarina Silva, Carl W. Akerlof, Jilei Xu, C. Nehrkorn, H. J. Birch, J. Balajthy, M.I. Lopes, O. Jahangir, A. Monte, Daniel McKinsey, A. C. Kaboth, J. E. Y. Dobson, X. Xiang, A. Richards, C. Ghag, V. A. Kudryavtsev, C. Chan, A. Vaitkus, S. Kravitz, D. Khaitan, J. J. Wang, C. M. Ignarra, P. A. Terman, D. Bauer, M. F. Marzioni, A. Tomás, L. Kreczko, J. R. Watson, A. Harrison, R. L. Mannino, Antonin Vacheret, S. J. Haselschwardt, M. Arthurs, F. Neves, W. Wang, E. D. Fraser, P. Sorensen, E. Leason, T. J. Sumner, P. Brás, Henning Flaecher, Benjamin Krikler, K. T. Lesko, Yue Meng, T. J. Whitis, X. Bai, E. Mizrachi, J. Johnson, S. R. Eriksen, Duncan Carlsmith, Wolfgang Lorenzon, X. Liu, N. Swanson, J. R. Bensinger, Eli Gibson, A. Kamaha, H. N. Nelson, W. Turner, C. Nedlik, Henrique Araujo, C. R. Hall, R. Cabrita, H. Kraus, R. Liu, Richard Rosero, D. R. Tronstad, R. C. Webb, L. de Viveiros, K. Stifter, S. Fiorucci, J. Liao, J. A. Morad, J. Bang, J. A. Nikoleyczik, M. Horn, C. D. Kocher, J. M. Lyle, Robert A. Taylor, S. Alsum, I. Khurana, A. Stevens, and Bjoern Penning
Subjects: Physics, Particle physics, Physics - Instrumentation and Detectors, hep-ex, 010308 nuclear & particles physics, Physics::Instrumentation and Detectors, Monte Carlo method, Detector, Dark matter, FOS: Physical sciences, Astronomy and Astrophysics, Instrumentation and Detectors (physics.ins-det), 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), WIMP, 0103 physical sciences, Sensitivity (control systems), Projection (set theory), physics.ins-det, 010303 astronomy & astrophysics, Event (particle physics), Background radiation
Abstract: The LUX-ZEPLIN dark matter search aims to achieve a sensitivity to the WIMP-nucleon spin-independent cross-section down to (1--2)$\times10^{-12}$\,pb at a WIMP mass of 40 GeV/$c^2$. This paper describes the simulations framework that, along with radioactivity measurements, was used to support this projection, and also to provide mock data for validating reconstruction and analysis software. Of particular note are the event generators, which allow us to model the background radiation, and the detector response physics used in the production of raw signals, which can be converted into digitized waveforms similar to data from the operational detector. Inclusion of the detector response allows us to process simulated data using the same analysis routines as developed to process the experimental data., Comment: 24 pages, 19 figures; Corresponding Authors: A. Cottle, V. Kudryavtsev, D. Woodward
Published: 2020
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10. The LUX-ZEPLIN (LZ) Experiment

Author: P. Sorensen, J. C. Davis, J. J. Silk, M. C. Carmona-Benitez, E. Holtom, T. J. Anderson, A. B.M.R. Sazzad, V.V. Sosnovtsev, J. J. Cherwinka, V. B. Francis, A. Naylor, L. Korley, K. Kamdin, W. Craddock, P. Beltrame, X. Xiang, A. Manalaysay, P. R. Scovell, D. Q. Huang, Ethan Bernard, B. P. Tennyson, Yue Meng, I. B. Peterson, A. Cottle, A. Biekert, A. Kamaha, M. S. Witherell, R. Studley, M. E. Monzani, J. S. Campbell, Alexander Bolozdynya, C. Chiller, M. G. D. van der Grinten, Matthew Szydagis, C. O. Vuosalo, M. Tan, E. H. Miller, V. Bugaev, B. Boxer, R. Coughlen, J. Liao, I. Stancu, L. de Viveiros, P. MarrLaundrie, A. Lambert, L. Kreczko, J. R. Watson, Michael Schubnell, A. Piepke, S. Greenwood, J. P. Coleman, A. Geffre, D. Bauer, G. W. Shutt, W. H. Lippincott, Y. Qie, Dongming Mei, L. Sabarots, S. Hans, Bhawna Gomber, W. Skulski, J. A. Nikkel, S. A. Hertel, A. Arbuckle, F.-T. Liao, S. R. Eriksen, Daniel McKinsey, E. Druszkiewicz, Jilei Xu, P. Sutcliffe, H. J. Rose, C. Nehrkorn, K. T. Lesko, N. A. Larsen, C. Lee, B. Landerud, Martin Breidenbach, D. Molash, Candace Lynch, W. G. Jones, M. A. Olevitch, Ian S. Young, M. Sarychev, B. N. Edwards, A. Pagac, L. Tvrznikova, P. Ford, S. Luitz, T. J. R. Davison, D. Pagenkopf, P. Majewski, G. Gregerson, Chao Zhang, Mary Severson, A. Currie, Ross G. White, Carl Gwilliam, S. J. Patton, A. J. Bailey, David Colling, Minfang Yeh, K. Wilson, P. Rossiter, S. Alsum, G. Pereira, V. M. Gehman, A. Dushkin, I. Khurana, Richard J. Smith, Benjamin Krikler, N. Marangou, John Heise, C. Loniewski, J. Bang, J. A. Nikoleyczik, J. Belle, D. Yu. Akimov, E. Mizrachi, C. Levy, M. R. While, A. Dobi, H. N. Nelson, X. Bai, J. Johnson, J. O'Dell, W. T. Kim, S. Weatherly, L. Wang, P. Johnson, Elena Korolkova, S. Pierson, W. T. Emmet, K. Stifter, B. Birrittella, T. Tope, A. Richards, Yufeng Wang, Ren-Jie Wang, J. Genovesi, C. Maupin, Kathrin C. Walker, G. R. C. Rischbieter, Eli Gibson, Yeongduk Kim, W. Turner, S. D. Worm, E. M. Boulton, G. Rutherford, S. Kyre, J. Mock, Seth Hillbrand, D. White, Q. Xiao, Sridhara Dasu, R. Leonard, J. Y.K. Hor, B. Holbrook, C. Nedlik, S. Fiorucci, J. Keefner, J. Kras, J. Yin, F. Froborg, F. Neves, D. Khaitan, S. J. Haselschwardt, L. Oxborough, D.S. Hamilton, O. Hitchcock, J.P. da Cunha, J.S. Saba, Henrique Araujo, I. Olcina, David Leonard, A. Bhatti, U. Utku, W. J. Wisniewski, S. Powell, M. Pangilinan, F.L.H. Wolfs, J. Barthel, D. Naim, D. Hemer, M. Timalsina, B. J. Mount, T. A. Shutt, S. Shaw, J. A. Morad, N. Swanson, J.P. Rodrigues, J. Nesbit, W.L. Waldron, J. E. Y. Dobson, J. Busenitz, C. R. Hall, N. Stern, C. Rhyne, A. Cole, R. J. Gaitskell, T. K. Edberg, Q. Riffard, O. Jahangir, B. G. Lenardo, D. Temples, C. Chan, C. E. Tull, A. Vaitkus, D. Garcia, S. Kravitz, T. G. Gonda, M. Elnimr, K. Pushkin, M. Horn, Kareem Kazkaz, H. Kraus, J. Li, C. H. Faham, T.M. Stiegler, A. Monte, C. D. Kocher, T. P. Biesiadzinski, C. Ghag, J. E. Armstrong, H. S. Lee, W. R. Edwards, K. J. Palladino, T. Benson, J. H. Buckley, Z. J. Minaker, Carl W. Akerlof, R. Bunker, M. Solmaz, M. Koyuncu, J.R. Verbus, J. M. Lyle, C. E. Dahl, E. Morrison, J. E. Cutter, J. Reichenbacher, H.J. Krebs, J. So, S. Branson, Peter Bauer, H. Auyeung, D. Seymour, Michele Cascella, A. A. Chiller, Mani Tripathi, Richard Rosero, D. R. Tronstad, R. Liu, M. Khaleeq, N. Decheine, M. N. Irving, Yunpeng Liu, S. Uvarov, J. McLaughlin, A. R. Smith, S. Dardin, J. Thomson, K. Sundarnath, Robert A. Taylor, Ben Carlson, T. Harrington, C. T. McConnell, E. K. Pease, A. Greenall, T. J. Whitis, M. F. Marzioni, C. Silva, V. Kasey, D. Rynders, R. C. Webb, J. Palmer, P. Brás, V. N. Solovov, T.J. Martin, R. Conley, P. A. Terman, A. Tomás, B. Lopez Paredes, K. E. Boast, J. T. White, D. Markley, A. Konovalov, A. Lindote, A. Alquahtani, L. Reichhart, D.C. Malling, K. C. Oliver-Mallory, E. Leason, Juhyeong Lee, D. Curran, Henning Flaecher, S. Balashov, A.V. Khromov, B. N. Ratcliff, J. Migneault, A. V. Kumpan, Simon Fayer, Antonin Vacheret, C. Hjemfelt, R. Linehan, M. Arthurs, S. Stephenson, V. M. Palmaccio, N. I. Chott, M.R. Stark, Duncan Carlsmith, Wenzhao Wei, M. Utes, Laura Manenti, A. Stevens, D. J. Taylor, R. E. Smith, V. A. Kudryavtsev, S. Walcott, C. M. Ignarra, N.J. Gantos, R. G. Jacobsen, M. Racine, A. Fan, Bjoern Penning, J. Va’vra, A. Harrison, H. Oh, J. Makkinje, W. Ji, R. Rucinski, Sergey Burdin, A. Baxter, D. Santone, E. Voirin, R.M. Gerhard, T.W. Hurteau, K.J. Thomas, X. Liu, R. Gelfand, T. Vietanen, A. Nilima, R. M. Preece, A. Laundrie, Mikkel B. Johnson, K. Hanzel, F. G. O'Neill, A. Khazov, W. C. Taylor, J. Balajthy, M.J. Barry, K. O’Sullivan, D. Lucero, A. C. Kaboth, R. L. Mannino, J. D. Wolfs, J. Lin, C. Pereira, N. Angelides, S. Gokhale, A. St. J. Murphy, Adam Bernstein, M. Hoff, M.I. Lopes, M. G. D. Gilchriese, C. Carels, I. M. Fogarty Florang, J. Edwards, S. N. Jeffery, R. W. Schnee, S. Pal, R. Bramante, T. Fruth, T. J. Sumner, W. H. To, Wolfgang Lorenzon, J. R. Bensinger, J. J. Wang, D. Woodward, C. Hasselkus, K. Skarpaas, D. R. Tiedt, D. S. Akerib, and Science and Technology Facilities Council (STFC)
Subjects: Nuclear and High Energy Physics, Technology, Physics - Instrumentation and Detectors, 0299 Other Physical Sciences, Dark matter, FOS: Physical sciences, chemistry.chemical_element, Scintillator, 01 natural sciences, 7. Clean energy, Physics, Particles & Fields, High Energy Physics - Experiment, Nuclear physics, LEAD, High Energy Physics - Experiment (hep-ex), XENON, Low energy, Xenon, WIMP, 0103 physical sciences, 0201 Astronomical and Space Sciences, 010306 general physics, Nuclear Science & Technology, Underground, Instrumentation and Methods for Astrophysics (astro-ph.IM), Instrumentation, Instruments & Instrumentation, physics.ins-det, Physics, Dark matter detector, Time projection chamber, Science & Technology, 010308 nuclear & particles physics, hep-ex, Detector, Instrumentation and Detectors (physics.ins-det), Nuclear & Particles Physics, Neutron capture, Physics, Nuclear, chemistry, Physical Sciences, 0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics, Liquid xenon, EMISSION, Astrophysics - Instrumentation and Methods for Astrophysics, astro-ph.IM
Abstract: We describe the design and assembly of the LUX-ZEPLIN experiment, a direct detection search for cosmic WIMP dark matter particles. The centerpiece of the experiment is a large liquid xenon time projection chamber sensitive to low energy nuclear recoils. Rejection of backgrounds is enhanced by a Xe skin veto detector and by a liquid scintillator Outer Detector loaded with gadolinium for efficient neutron capture and tagging. LZ is located in the Davis Cavern at the 4850' level of the Sanford Underground Research Facility in Lead, South Dakota, USA. We describe the major subsystems of the experiment and its key design features and requirements. info:eu-repo/semantics/publishedVersion
Published: 2019
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11. Results of a Search for Sub-GeV Dark Matter Using 2013 LUX Data

Author: D. P. Hogan, M. G. D. Gilchriese, K. T. Lesko, Henrique Araujo, Sergey Burdin, C. Ghag, Q. Riffard, L. Tvrznikova, J. Lin, C. R. Hall, A. Naylor, S. Alsum, S. J. Haselschwardt, T. J. R. Davison, S. Shaw, Matthew Szydagis, P. A. Terman, D. Q. Huang, Carl Gwilliam, M. Moongweluwan, J. Genovesi, Jilei Xu, C. Nehrkorn, M. S. Witherell, O. Jahangir, Daniel McKinsey, D. Byram, S. Uvarov, X. Bai, C. Chan, S. Kravitz, H. N. Nelson, M. Horn, R. G. Jacobsen, F. Neves, J. E. Cutter, V. Velan, A. Fan, Kareem Kazkaz, A. Manalaysay, T. P. Biesiadzinski, W. Ji, B. Boxer, M. C. Carmona-Benitez, P. Sorensen, P. Brás, T. J. Whitis, K. J. Palladino, K. Kamdin, Ethan Bernard, F.L.H. Wolfs, P. Beltrame, Dongming Mei, D. J. Taylor, B. P. Tennyson, T. A. Shutt, J. A. Morad, U. Utku, C. Rhyne, E. K. Pease, C. Silva, R. L. Mannino, Elena Korolkova, R. J. Gaitskell, V. N. Solovov, K. C. Oliver-Mallory, M. F. Marzioni, S. A. Hertel, E. Druszkiewicz, K. Yazdani, G. R. C. Rischbieter, Chao Zhang, D. Khaitan, S. R. Fallon, N. Marangou, V. A. Kudryavtsev, D. R. Tiedt, J. T. White, C. M. Ignarra, D. S. Akerib, E. M. Boulton, T. J. Sumner, W. H. To, A. Lindote, D. Woodward, A. St. J. Murphy, Adam Bernstein, W. C. Taylor, M.I. Lopes, R. Knoche, J. Balajthy, J. Liao, Mani Tripathi, R. C. Webb, S. Fiorucci, P. Rossiter, B. G. Lenardo, M. Solmaz, Science and Technology Facilities Council (STFC), and The Royal Society
Subjects: General Physics, Physics - Instrumentation and Detectors, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Physics::Instrumentation and Detectors, Physics, Multidisciplinary, Dark matter, FOS: Physical sciences, General Physics and Astronomy, chemistry.chemical_element, Electron, 01 natural sciences, 7. Clean energy, 09 Engineering, High Energy Physics - Experiment, LUX Collaboration, Nuclear physics, High Energy Physics - Experiment (hep-ex), Xenon, Recoil, Ionization, 0103 physical sciences, Nuclear Experiment, 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), physics.ins-det, 01 Mathematical Sciences, Physics, Scintillation, Science & Technology, 02 Physical Sciences, hep-ex, Scattering, Instrumentation and Detectors (physics.ins-det), chemistry, Physical Sciences, Scintillation counter, astro-ph.CO, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics, astro-ph.IM
Abstract: The scattering of dark matter (DM) particles with sub-GeV masses off nuclei is difficult to detect using liquid xenon-based DM search instruments because the energy transfer during nuclear recoils is smaller than the typical detector threshold. However, the tree-level DM-nucleus scattering diagram can be accompanied by simultaneous emission of a Bremsstrahlung photon or a so-called "Migdal" electron. These provide an electron recoil component to the experimental signature at higher energies than the corresponding nuclear recoil. The presence of this signature allows liquid xenon detectors to use both the scintillation and the ionization signals in the analysis where the nuclear recoil signal would not be otherwise visible. We report constraints on spin-independent DM-nucleon scattering for DM particles with masses of 0.4-5 GeV/c$^2$ using 1.4$\times10^4$ kg$\cdot$day of search exposure from the 2013 data from the Large Underground Xenon (LUX) experiment for four different classes of mediators. This analysis extends the reach of liquid xenon-based DM search instruments to lower DM masses than has been achieved previously.
Published: 2019
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12. LUX trigger efficiency

Author: A. Manalaysay, T. A. Shutt, D. Khaitan, A. Lindote, Daniel McKinsey, S. R. Fallon, J.R. Verbus, Ethan Bernard, F. L. H. Wolfs, Kareem Kazkaz, Henrique Araujo, U. Utku, T. P. Biesiadzinski, P. Sorensen, Mani Tripathi, S. A. Hertel, C. R. Hall, E. Druszkiewicz, K. Yazdani, G. R. C. Rischbieter, B. P. Tennyson, M. G. D. Gilchriese, K. J. Palladino, M. C. Carmona-Benitez, W. H. To, E. K. Pease, L. Tvrznikova, K. Kamdin, P. Beltrame, J. T. White, D. Woodward, V. N. Solovov, D. Byram, P. Rossiter, V. Velan, K. C. Oliver-Mallory, P. A. Terman, J. A. Morad, Carl Gwilliam, K. T. Lesko, D. P. Hogan, Matthew Szydagis, H. N. Nelson, S. Shaw, B. G. Lenardo, B. Boxer, M. S. Witherell, S. Fiorucci, W. C. Taylor, Elena Korolkova, M. Solmaz, A. Fan, J. Balajthy, D. S. Akerib, D. Q. Huang, T. J. Whitis, R. L. Mannino, X. Bai, J. Genovesi, Jilei Xu, C. Nehrkorn, S. Uvarov, S. J. Haselschwardt, T. J. R. Davison, M. Horn, P. Brás, S. Alsum, J. Lin, M. Moongweluwan, R. C. Webb, A. St. J. Murphy, D. J. Taylor, Adam Bernstein, M. F. Marzioni, M.I. Lopes, R. Knoche, J. E. Cutter, V. A. Kudryavtsev, D. R. Tiedt, C. M. Ignarra, E. M. Boulton, T. J. Sumner, J. Liao, C. Ghag, C. Rhyne, R. J. Gaitskell, Sergey Burdin, Dongming Mei, Chao Zhang, N. Marangou, F. Neves, Catarina Silva, C. Chan, S. Kravitz, E. Grace, R. G. Jacobsen, and W. Ji
Subjects: Technology, Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Photon, Large Underground Xenon experiment, Physics::Instrumentation and Detectors, Dark matter, chemistry.chemical_element, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, 7. Clean energy, Atomic, Physics, Particles & Fields, Nuclear physics, 0202 Atomic, Molecular, Nuclear, Particle And Plasma Physics, Xenon, Recoil, Particle and Plasma Physics, WIMP, Affordable and Clean Energy, 0103 physical sciences, Calibration, Nuclear, Nuclear Science & Technology, 010306 general physics, Instruments & Instrumentation, Instrumentation, physics.ins-det, Physics, Dark matter detectors, Science & Technology, 010308 nuclear & particles physics, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Molecular, Instrumentation and Detectors (physics.ins-det), Nuclear & Particles Physics, WIMPs, Other Physical Sciences, Physics, Nuclear, chemistry, Physical Sciences, Liquid xenon, Trigger efficiency, Astronomical and Space Sciences
Abstract: The Large Underground Xenon experiment (LUX) searches for dark matter using a dual-phase xenon detector. LUX uses a custom-developed trigger system for event selection. In this paper, the trigger efficiency, which is defined as the probability that an event of interest is selected for offline analysis, is studied using raw data obtained from both electron recoil (ER) and nuclear recoil (NR) calibrations. The measured efficiency exceeds 98\% at a pulse area of 90 detected photons, which is well below the WIMP analysis threshold on the S2 pulse area. The efficiency also exceeds 98\% at recoil energies of \mbox{0.2 keV} and above for ER, and \mbox{1.3 keV} and above for NR. The measured trigger efficiency varies between 99\% and 100\% over the fiducial volume of the detector., Comment: 31 pages, 14 figures
Published: 2018
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13. Search for annual and diurnal rate modulations in the LUX experiment

Author: T. J. Sumner, A. St. J. Murphy, Adam Bernstein, S. Uvarov, M.I. Lopes, R. Knoche, D. S. Akerib, T. A. Shutt, J. A. Morad, A. Manalaysay, H. N. Nelson, Ethan Bernard, J. Liao, V. Velan, W. H. To, U. Utku, A. Lindote, M. Horn, M. F. Marzioni, D. Woodward, R. L. Mannino, T. J. R. Davison, Mani Tripathi, P. Rossiter, S. J. Haselschwardt, Sergey Burdin, W. C. Taylor, D. Q. Huang, K. T. Lesko, Matthew Szydagis, T. J. Whitis, E. M. Boulton, X. Bai, K. Kazkaz, R. C. Webb, J. Balajthy, J. Genovesi, Jilei Xu, B. G. Lenardo, D. J. Taylor, C. Nehrkorn, J. Lin, F.L.H. Wolfs, M. Solmaz, F. Neves, S. Shaw, J.R. Verbus, D. Byram, S. Fiorucci, C. Ghag, M. C. Carmona-Benitez, Chao Zhang, K. Kamdin, P. Beltrame, P. A. Terman, S. Alsum, M. Moongweluwan, B. Boxer, J. T. White, M. G. D. Gilchriese, T. P. Biesiadzinski, J. E. Cutter, P. Sorensen, C. Rhyne, R. J. Gaitskell, B. P. Tennyson, L. Tvrznikova, Carl Gwilliam, Elena Korolkova, G. R. C. Rischbieter, Henrique Araujo, C. R. Hall, Daniel McKinsey, D. Khaitan, S. R. Fallon, N. Marangou, Dongming Mei, A. Fan, P. Brás, S. A. Hertel, K. J. Palladino, E. Druszkiewicz, C. Chan, S. Kravitz, K. Yazdani, D. P. Hogan, E. K. Pease, Michael S. Witherell, C. Silva, V. N. Solovov, K. C. Oliver-Mallory, R. G. Jacobsen, W. Ji, V. A. Kudryavtsev, D. R. Tiedt, C. M. Ignarra, Science and Technology Facilities Council (STFC), and The Royal Society
Subjects: Cosmology and Nongalactic Astrophysics (astro-ph.CO), Physics - Instrumentation and Detectors, Rate modulation, Dark matter, FOS: Physical sciences, Astrophysics, Astronomy & Astrophysics, 01 natural sciences, Atomic, High Energy Physics - Experiment, Physics, Particles & Fields, High Energy Physics - Experiment (hep-ex), Recoil, Particle and Plasma Physics, 0103 physical sciences, Modulation (music), DARK-MATTER, Nuclear, 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), physics.ins-det, Physics, Quantum Physics, Science & Technology, 010308 nuclear & particles physics, hep-ex, Molecular, Instrumentation and Detectors (physics.ins-det), Nuclear & Particles Physics, Amplitude, Physical Sciences, astro-ph.CO, Halo, Astrophysics - Instrumentation and Methods for Astrophysics, Tonne, Astronomical and Space Sciences, Astrophysics - Cosmology and Nongalactic Astrophysics, astro-ph.IM
Abstract: Various dark matter models predict annual and diurnal modulations of dark matter interaction rates in Earth-based experiments as a result of the Earth's motion in the halo. Observation of such features can provide generic evidence for detection of dark matter interactions. This paper reports a search for both annual and diurnal rate modulations in the LUX dark matter experiment using over 20 calendar months of data acquired between 2013 and 2016. This search focuses on electron recoil events at low energies, where leptophilic dark matter interactions are expected to occur and where the DAMA experiment has observed a strong rate modulation for over two decades. By using the innermost volume of the LUX detector and developing robust cuts and corrections, we obtained a stable event rate of 2.3$\pm$0.2~cpd/keV$_{\text{ee}}$/tonne, which is among the lowest in all dark matter experiments. No statistically significant annual modulation was observed in energy windows up to 26~keV$_{\text{ee}}$. Between 2 and 6~keV$_{\text{ee}}$, this analysis demonstrates the most sensitive annual modulation search up to date, with 9.2$\sigma$ tension with the DAMA/LIBRA result. We also report no observation of diurnal modulations above 0.2~cpd/keV$_{\text{ee}}$/tonne amplitude between 2 and 6~keV$_{\text{ee}}$., Comment: 12 pages, 9 figures
Published: 2018
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14. Position Reconstruction in LUX

Author: B. N. Edwards, Henrique Araujo, K. O’Sullivan, V. Velan, J. E. Cutter, E. M. Boulton, T. J. Sumner, R. G. Jacobsen, A. Fan, Matthew Szydagis, C. Rhyne, R. J. Gaitskell, C. Ghag, X. Bai, R. L. Mannino, W. Ji, D. Q. Huang, Kareem Kazkaz, T. P. Biesiadzinski, A. Lindote, S. Alsum, A. St. J. Murphy, Adam Bernstein, K. J. Palladino, S. J. Haselschwardt, J. Mock, C. R. Hall, M. G. D. Gilchriese, M.I. Lopes, R. Knoche, M. Moongweluwan, E. K. Pease, C. Silva, T. A. Shutt, A. J. Bailey, J. A. Morad, V. N. Solovov, K. C. Oliver-Mallory, D. Byram, Dongming Mei, L. Tvrznikova, C. Chan, M. Hanhardt, D. J. Taylor, K. T. Lesko, N. A. Larsen, J. Genovesi, Jilei Xu, D. S. Akerib, C. Nehrkorn, W. C. Taylor, F.L.H. Wolfs, D. Khaitan, A. Currie, D. P. Hogan, S. A. Hertel, S. Shaw, M. F. Marzioni, S. R. Fallon, P. A. Terman, E. Druszkiewicz, J. Balajthy, K. Yazdani, S. Uvarov, M. S. Witherell, M. Horn, Chao Zhang, A. Dobi, H. N. Nelson, M. C. Carmona-Benitez, K. Kamdin, P. Beltrame, P. Sorensen, Daniel McKinsey, B. P. Tennyson, S. Fiorucci, A. Manalaysay, F. Neves, Mani Tripathi, W. H. To, T. J. R. Davison, Ethan Bernard, R. C. Webb, Sarah Young, D. R. Tiedt, C. M. Ignarra, P. Brás, Sidney Cahn, B. G. Lenardo, M. Solmaz, T. J. Whitis, J.R. Verbus, and J. T. White
Subjects: Technology, Liquid detectors, Photomultiplier, Photon, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, chemistry.chemical_element, Electron, 01 natural sciences, law.invention, High Energy Physics - Experiment, Dark Matter detectors (WIMPs, axions, etc.), XENON, Optics, Xenon, law, 0103 physical sciences, Calibration, 010306 general physics, Instruments & Instrumentation, DETECTOR, physics.ins-det, Instrumentation, Mathematical Physics, Gamma camera, Detector modelling and simulations I (interaction of radiation with matter, interaction of photons with matter, interaction of hadrons with matter, etc), Physics, Science & Technology, hep-ex, 010308 nuclear & particles physics, business.industry, Charge transport, multiplication and electroluminescence in rare gases and liquids, Detector, Nuclear & Particles Physics, Photon counting, GAMMA-CAMERA, chemistry, physics.comp-ph, EMISSION, business, Physics - Computational Physics
Abstract: The $(x, y)$ position reconstruction method used in the analysis of the complete exposure of the Large Underground Xenon (LUX) experiment is presented. The algorithm is based on a statistical test that makes use of an iterative method to recover the photomultiplier tube (PMT) light response directly from the calibration data. The light response functions make use of a two dimensional functional form to account for the photons reflected on the inner walls of the detector. To increase the resolution for small pulses, a photon counting technique was employed to describe the response of the PMTs. The reconstruction was assessed with calibration data including ${}^{\mathrm{83m}}$Kr (releasing a total energy of 41.5 keV) and ${}^{3}$H ($\beta^-$ with Q = 18.6 keV) decays, and a deuterium-deuterium (D-D) neutron beam (2.45 MeV). In the horizontal plane, the reconstruction has achieved an $(x, y)$ position uncertainty of $\sigma$= 0.82 cm for events of only 200 electroluminescence photons and $\sigma$ = 0.17 cm for 4,000 electroluminescence photons. Such signals are associated with electron recoils of energies $\sim$0.25 keV and $\sim$10 keV, respectively. The reconstructed position of the smallest events with a single electron emitted from the liquid surface has a horizontal $(x, y)$ uncertainty of 2.13 cm., Comment: 30 pages, 17 figures
Published: 2018

15. Projected WIMP sensitivity of the LUX-ZEPLIN (LZ) dark matter experiment

Author: M. Sarychev, T. K. Edberg, B. Boxer, D. Temples, K. Pushkin, A. Dobi, H. N. Nelson, K. J. Palladino, J. H. Buckley, S. Kyre, Simon Fayer, K. Stifter, J.S. Saba, S. Powell, Henrique Araujo, B. J. Mount, T. A. Shutt, J. A. Morad, J. Reichenbacher, J. E. Y. Dobson, J.R. Verbus, U. Utku, C. Chan, C. E. Tull, F. Neves, V. A. Kudryavtsev, W. Skulski, S. Luitz, J. Yin, S. J. Haselschwardt, R. Linehan, C. M. Ignarra, D. J. Taylor, E. K. Pease, C. Silva, J. Lin, S. Fiorucci, Vv. Bugaev, V. N. Solovov, C. D. Kocher, C. Levy, Sergey Burdin, Bjoern Penning, K. C. Oliver-Mallory, J. Li, E. H. Miller, P. Rossiter, X. Liu, T. Tope, A. Cottle, W. R. Edwards, R. Taylor, C. Ghag, W.L. Waldron, A. J. Bailey, Carl W. Akerlof, Minfang Yeh, Hoff, J. M. Lyle, Elena Korolkova, C. R. Hall, F.-T. Liao, W. H. Lippincott, Witherell, M. C. Carmona-Benitez, A. Piepke, S. Hans, R. L. Mannino, P. Sorensen, A. Manalaysay, T. Benson, S. A. Hertel, E. Voirin, D. Khaitan, Mgd van der Grinten, A. Richards, K. Kamdin, W. Craddock, Ethan Bernard, E. Druszkiewicz, H. Kraus, D. Q. Huang, P. Beltrame, W. J. Wisniewski, M. Timalsina, S. Shaw, Yue Meng, J. Y.K. Hor, L. Tvrznikova, A. Murphy, B. G. Lenardo, J. E. Cutter, K.J. Thomas, K. E. Boast, B. N. Ratcliff, T.M. Stiegler, A. Currie, T. J. Whitis, R. M. Preece, J. Va’vra, D. A. Bauer, M. Solmaz, E. Morrison, W. Ji, A. Fan, T. P. Biesiadzinski, J. Genovesi, Ian S. Young, Ben Carlson, Olevitch, S. J. Patton, C. E. Dahl, X. Bai, P. Brás, Michael Schubnell, C. Maupin, J. Mock, I. Stancu, Daniel McKinsey, J. A. Nikoleyczik, J. Belle, A. Lindote, David Leonard, S. Alsum, P. A. Terman, M. E. Monzani, Juhyeong Lee, Matthew Szydagis, L. Kreczko, J. R. Watson, Duncan Carlsmith, S. Balashov, K. T. Lesko, Mani Tripathi, Richard Rosero, J.P. Rodrigues, J. Busenitz, C. Rhyne, H.J. Krebs, Antonin Vacheret, C. Hjemfelt, A. Cole, R. J. Gaitskell, L.D. Viveiros, M. Arthurs, M.R. Stark, A. Tomás, R. C. Webb, D. White, K. O'Sullivan, J. Keefner, J. Liao, I. Olcina, F.L.H. Wolfs, Peter Majewski, J. J. Cherwinka, D. S. Akerib, A. Khazov, J.J. Silk, Wolfgang Lorenzon, W. C. Taylor, K. Hanzel, K. Skarpaas, J. Balajthy, Benjamin Krikler, T. Fruth, M. G. D. Gilchriese, C. Carels, Yeongduk Kim, W. H. To, S. D. Worm, Seth Hillbrand, Asher Kaboth, D. Woodward, P.R. Scovell, B.L. Paredes, R. W. Schnee, M.I. Lopes, and Science and Technology Facilities Council (STFC)
Subjects: BACKGROUNDS, Physics - Instrumentation and Detectors, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Dark matter, chemistry.chemical_element, FOS: Physical sciences, Astronomy & Astrophysics, GASES, 01 natural sciences, 7. Clean energy, High Energy Physics - Experiment, Physics, Particles & Fields, Galactic halo, Nuclear physics, XENON, LIMITS, High Energy Physics - Experiment (hep-ex), Xenon, Recoil, WIMP, RADIOACTIVITY, 0103 physical sciences, 010306 general physics, DETECTOR, physics.ins-det, Instrumentation and Methods for Astrophysics (astro-ph.IM), Physics, Science & Technology, 010308 nuclear & particles physics, hep-ex, Detector, Instrumentation and Detectors (physics.ins-det), chemistry, Weakly interacting massive particles, LOADED LIQUID SCINTILLATOR, Physical Sciences, SIMULATION, astro-ph.CO, RECOIL, Astrophysics - Instrumentation and Methods for Astrophysics, EMISSION, Sensitivity (electronics), Astrophysics - Cosmology and Nongalactic Astrophysics, astro-ph.IM
Abstract: LUX-ZEPLIN (LZ) is a next generation dark matter direct detection experiment that will operate 4850 feet underground at the Sanford Underground Research Facility (SURF) in Lead, South Dakota, USA. Using a two-phase xenon detector with an active mass of 7~tonnes, LZ will search primarily for low-energy interactions with Weakly Interacting Massive Particles (WIMPs), which are hypothesized to make up the dark matter in our galactic halo. In this paper, the projected WIMP sensitivity of LZ is presented based on the latest background estimates and simulations of the detector. For a 1000~live day run using a 5.6~tonne fiducial mass, LZ is projected to exclude at 90\% confidence level spin-independent WIMP-nucleon cross sections above $1.4 \times 10^{-48}$~cm$^{2}$ for a 40~$\mathrm{GeV}/c^{2}$ mass WIMP. Additionally, a $5\sigma$ discovery potential is projected reaching cross sections below the exclusion limits of recent experiments. For spin-dependent WIMP-neutron(-proton) scattering, a sensitivity of $2.3 \times 10^{-43}$~cm$^{2}$ ($7.1 \times 10^{-42}$~cm$^{2}$) for a 40~$\mathrm{GeV}/c^{2}$ mass WIMP is expected. With underground installation well underway, LZ is on track for commissioning at SURF in 2020., Comment: 14 pages, 11 figures
Published: 2018
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16. Chromatographic separation of radioactive noble gases from xenon

Author: Mani Tripathi, X. Bai, D. J. Taylor, A. Dobi, R. C. Webb, S. Fiorucci, H. N. Nelson, J. Mock, K. Pech, R.G. Jacobsen, C. H. Faham, P. Sorensen, L. Tvrznikova, C. Ghag, M. Moongweluwan, A. J. Bailey, M. Hanhardt, Chao Zhang, B. G. Lenardo, S. Shaw, P. Phelps, A. Bernstein, A. St. J. Murphy, Henrique Araujo, M. G. D. Gilchriese, A. Manalaysay, C. Chan, N.A. Larsen, R. Bramante, T. A. Shutt, V. M. Gehman, J. A. Morad, J. E. Cutter, J. E. Y. Dobson, C. R. Hall, F. Neves, M.I. Lopes, R. Knoche, A. Lindote, Ethan Bernard, S. A. Hertel, E. Druszkiewicz, K. Yazdani, L. Reichhart, B. N. Edwards, Daniel McKinsey, W. H. To, M. F. Marzioni, T. P. Biesiadzinski, D. M. Mei, R. L. Mannino, T. J. R. Davison, K. Kazkaz, C. Chiller, K. T. Lesko, D. Q. Huang, C. Lee, K. O’Sullivan, C. Rhyne, P. A. Terman, R. J. Gaitskell, J. T. White, Michael S. Witherell, T. Coffey, K. J. Palladino, A.A. Chiller, Sidney Cahn, W. C. Taylor, J. Balajthy, K.R. Gibson, E. K. Pease, C. Silva, M. Ihm, A. Currie, S. Uvarov, K. C. Oliver-Mallory, V. N. Solovov, T. J. Whitis, D. P. Hogan, J.R. Verbus, M. Horn, Matthew Szydagis, B. P. Tennyson, D. Khaitan, S. Stephenson, Sarah Young, F.L.H. Wolfs, C. Nehrkorn, D. R. Tiedt, C. M. Ignarra, W. Ji, S. J. Haselschwardt, E. M. Boulton, M. C. Carmona-Benitez, K. Kamdin, P. Beltrame, T. J. Sumner, and D. S. Akerib
Subjects: Physics - Instrumentation and Detectors, Trace Amounts, chemistry.chemical_element, FOS: Physical sciences, Mass spectrometry, 01 natural sciences, 7. Clean energy, Nuclear physics, 0202 Atomic, Molecular, Nuclear, Particle And Plasma Physics, Adsorption, Xenon, Impurity, 0103 physical sciences, Gas separation, 010306 general physics, physics.ins-det, Physics, 010308 nuclear & particles physics, Radiochemistry, Krypton, Astronomy and Astrophysics, Instrumentation and Detectors (physics.ins-det), Nuclear & Particles Physics, 0201 Astronomical And Space Sciences, chemistry, 13. Climate action, Weakly interacting massive particles
Abstract: The Large Underground Xenon (LUX) experiment operates at the Sanford Underground Research Facility to detect nuclear recoils from the hypothetical Weakly Interacting Massive Particles (WIMPs) on a liquid xenon target. Liquid xenon typically contains trace amounts of the noble radioactive isotopes $^{85}$Kr and $^{39}$Ar that are not removed by the in situ gas purification system. The decays of these isotopes at concentrations typical of research-grade xenon would be a dominant background for a WIMP search exmperiment. To remove these impurities from the liquid xenon, a chromatographic separation system based on adsorption on activated charcoal was built. 400 kg of xenon was processed, reducing the average concentration of krypton from 130 ppb to 3.5 ppt as measured by a cold-trap assisted mass spectroscopy system. A 50 kg batch spiked to 0.001 g/g of krypton was processed twice and reduced to an upper limit of 0.2 ppt., Comment: Accepted in Astropart. Phys
Published: 2018
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17. Ultralow energy calibration of LUX detector using Xe127 electron capture

Author: Henrique Araujo, C. R. Hall, S. K. Young, D. J. Taylor, D. Byram, S. Shaw, A. Dobi, Sidney Cahn, S. A. Hertel, E. Druszkiewicz, K. Yazdani, M. S. Witherell, J. A. Morad, F. L. H. Wolfs, R. G. Jacobsen, J. E. Cutter, P. Brás, D. Q. Huang, B. N. Edwards, J. T. White, M. Hanhardt, Daniel McKinsey, X. Bai, W. Ji, S. Alsum, B. G. Lenardo, A. Manalaysay, M. Moongweluwan, C. Rhyne, R. J. Gaitskell, T. A. Shutt, D. R. Tiedt, J.R. Verbus, Ethan Bernard, C. M. Ignarra, D. M. Mei, Kareem Kazkaz, V. Velan, M. Solmaz, T. J. R. Davison, C. Ghag, T. P. Biesiadzinski, D. P. Hogan, K. T. Lesko, T. J. Whitis, S. Uvarov, N. A. Larsen, Chao Zhang, R. L. Mannino, K. O’Sullivan, M. Horn, Matthew Szydagis, M. G. D. Gilchriese, F. Neves, P. Sorensen, J. Mock, M. F. Marzioni, Mani Tripathi, B. P. Tennyson, S. Fiorucci, Jilei Xu, C. Nehrkorn, P. A. Terman, W. C. Taylor, J. Balajthy, W. H. To, R. C. Webb, S. R. Fallon, Catarina Silva, H. N. Nelson, C. Chan, D. S. Akerib, M. C. Carmona-Benitez, A. St. J. Murphy, K. Kamdin, Adam Bernstein, P. Beltrame, M.I. Lopes, R. Knoche, L. Tvrznikova, A. Currie, S. J. Haselschwardt, J. Genovesi, E. M. Boulton, T. J. Sumner, D. Khaitan, K. J. Palladino, E. K. Pease, V. N. Solovov, K. C. Oliver-Mallory, A. Fan, A. J. Bailey, and A. Lindote
Subjects: Physics, 010308 nuclear & particles physics, Electron capture, Binding energy, Analytical chemistry, chemistry.chemical_element, Electron, 01 natural sciences, Beta decay, Xenon, Recoil, chemistry, Ionization, 0103 physical sciences, Isotopes of xenon, 010306 general physics
Abstract: Author(s): Akerib, DS; Alsum, S; Araujo, HM; Bai, X; Bailey, AJ; Balajthy, J; Beltrame, P; Bernard, EP; Bernstein, A; Biesiadzinski, TP; Boulton, EM; Bras, P; Byram, D; Cahn, SB; Carmona-Benitez, MC; Chan, C; Currie, A; Cutter, JE; Davison, TJR; Dobi, A; Druszkiewicz, E; Edwards, BN; Fallon, SR; Fan, A; Fiorucci, S; Gaitskell, RJ; Genovesi, J; Ghag, C; Gilchriese, MGD; Hall, CR; Hanhardt, M; Haselschwardt, SJ; Hertel, SA; Hogan, DP; Horn, M; Huang, DQ; Ignarra, CM; Jacobsen, RG; Ji, W; Kamdin, K; Kazkaz, K; Khaitan, D; Knoche, R; Larsen, NA; Lenardo, BG; Lesko, KT; Lindote, A; Lopes, MI; Manalaysay, A; Mannino, RL; Marzioni, MF; McKinsey, DN; Mei, DM; Mock, J; Moongweluwan, M; Morad, JA; Murphy, ASJ; Nehrkorn, C; Nelson, HN; Neves, F; O'Sullivan, K; Oliver-Mallory, KC; Palladino, KJ; Pease, EK; Rhyne, C; Shaw, S; Shutt, TA; Silva, C; Solmaz, M; Solovov, VN; Sorensen, P; Sumner, TJ; Szydagis, M; Taylor, DJ; Taylor, WC; Tennyson, BP; Terman, PA; Tiedt, DR; To, WH; Tripathi, M; Tvrznikova, L; Uvarov, S; Velan, V; Verbus, JR; Webb, RC | Abstract: We report an absolute calibration of the ionization yields (Qy) and fluctuations for electronic recoil events in liquid xenon at discrete energies between 186 eV and 33.2 keV. The average electric field applied across the liquid xenon target is 180 V/cm. The data are obtained using low energy Xe127 electron capture decay events from the 95.0-day first run from LUX (WS2013) in search of weakly interacting massive particles. The sequence of gamma-ray and x-ray cascades associated with I127 deexcitations produces clearly identified two-vertex events in the LUX detector. We observe the K-(binding energy, 33.2 keV), L-(5.2 keV), M-(1.1 keV), and N-(186 eV) shell cascade events and verify that the relative ratio of observed events for each shell agrees with calculations. The N-shell cascade analysis includes single extracted electron (SE) events and represents the lowest-energy electronic recoil in situ measurements that have been explored in liquid xenon.
Published: 2017
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18. Kr83m calibration of the 2013 LUX dark matter search

Author: L. Tvrznikova, A. Currie, Witherell, D. Q. Huang, S. Uvarov, R. G. Jacobsen, B. G. Lenardo, A. Dobi, D. J. Taylor, D. M. Mei, J. A. Morad, P. Sorensen, T. J. R. Davison, M. C. Carmona-Benitez, M. Horn, Verbus, K. Kamdin, M. Solmaz, P. Beltrame, R. C. Webb, S. A. Hertel, T. J. Whitis, W. Ji, H. N. Nelson, D. Byram, K. Yazdani, B. P. Tennyson, S. Fiorucci, Sarah Young, Fallon, S. J. Haselschwardt, Catarina Silva, S. Alsum, C. M. Ignarra, M. Moongweluwan, Tiedt, K. T. Lesko, Velan, P. A. Terman, N. A. Larsen, P. Brás, A. Murphy, J. E. Cutter, C. Chan, X. Bai, K. Kazkaz, T. J. Sumner, M. Hanhardt, J. Mock, C. Rhyne, R. J. Gaitskell, A. Manalaysay, Ethan Bernard, F. Neves, M. G. D. Gilchriese, S. Shaw, C. Ghag, A. Fan, Chao Zhang, T. A. Shutt, E. Druszkiewicz, Sidney Cahn, M. F. Marzioni, K. O'Sullivan, K. C. Oliver-Mallory, D. Khaitan, J. T. White, F.L.H. Wolfs, D. P. Hogan, Mani Tripathi, Adam Bernstein, K. J. Palladino, E. K. Pease, V. N. Solovov, T. P. Biesiadzinski, A. Lindote, M.I. Lopes, R. Knoche, R. L. Mannino, A. J. Bailey, Blair Edwards, W. C. Taylor, Matthew Szydagis, J. Balajthy, J. Genovesi, Jilei Xu, C. Nehrkorn, Henrique Araujo, W. H. To, C. R. Hall, E. M. Boulton, Daniel McKinsey, and D. S. Akerib
Subjects: Combinatorics, Physics, 010308 nuclear & particles physics, 0103 physical sciences, Context (language use), 010306 general physics, 01 natural sciences
Abstract: Author(s): Akerib, DS; Alsum, S; Araujo, HM; Bai, X; Bailey, AJ; Balajthy, J; Beltrame, P; Bernard, EP; Bernstein, A; Biesiadzinski, TP; Boulton, EM; Bras, P; Byram, D; Cahn, SB; Carmona-Benitez, MC; Chan, C; Currie, A; Cutter, JE; Davison, TJR; Dobi, A; Druszkiewicz, E; Edwards, BN; Fallon, SR; Fan, A; Fiorucci, S; Gaitskell, RJ; Genovesi, J; Ghag, C; Gilchriese, MGD; Hall, CR; Hanhardt, M; Haselschwardt, SJ; Hertel, SA; Hogan, DP; Horn, M; Huang, DQ; Ignarra, CM; Jacobsen, RG; Ji, W; Kamdin, K; Kazkaz, K; Khaitan, D; Knoche, R; Larsen, NA; Lenardo, BG; Lesko, KT; Lindote, A; Lopes, MI; Manalaysay, A; Mannino, RL; Marzioni, MF; McKinsey, DN; Mei, DM; Mock, J; Moongweluwan, M; Morad, JA; Murphy, ASJ; Nehrkorn, C; Nelson, HN; Neves, F; O'Sullivan, K; Oliver-Mallory, KC; Palladino, KJ; Pease, EK; Rhyne, C; Shaw, S; Shutt, TA; Silva, C; Solmaz, M; Solovov, VN; Sorensen, P; Sumner, TJ; Szydagis, M; Taylor, DJ; Taylor, WC; Tennyson, BP; Terman, PA; Tiedt, DR; To, WH; Tripathi, M; Tvrznikova, L; Uvarov, S; Velan, V; Verbus, JR; Webb, RC | Abstract: LUX was the first dark matter experiment to use a Kr83m calibration source. In this paper, we describe the source preparation and injection. We also present several Kr83m calibration applications in the context of the 2013 LUX exposure, including the measurement of temporal and spatial variation in scintillation and charge signal amplitudes, and several methods to understand the electric field within the time projection chamber.
Published: 2017
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19. 3D Modeling of Electric Fields in the LUX Detector

Author: D. Q. Huang, P. A. Terman, S. Uvarov, M. Horn, A. Dobi, H. N. Nelson, Mani Tripathi, S. A. Hertel, J. Genovesi, Jilei Xu, M. G. D. Gilchriese, E. Druszkiewicz, T. J. R. Davison, C. Nehrkorn, S. Alsum, J. T. White, K. Yazdani, M. Hanhardt, W. C. Taylor, L. Tvrznikova, R. C. Webb, M. Moongweluwan, D. Byram, A. Lindote, Sarah Young, T. A. Shutt, J. A. Morad, A. Manalaysay, D. R. Tiedt, D. Khaitan, C. M. Ignarra, J. Balajthy, S. R. Fallon, A. J. Bailey, S. Fiorucci, A. Currie, T. J. Whitis, B. G. Lenardo, P. Brás, J.R. Verbus, K. T. Lesko, N. A. Larsen, D. J. Taylor, A. Fan, X. Bai, C. Chan, K. J. Palladino, F.L.H. Wolfs, B. N. Edwards, J. Mock, E. K. Pease, C. Silva, M. Solmaz, Ethan Bernard, Kareem Kazkaz, V. N. Solovov, K. C. Oliver-Mallory, P. Sorensen, Sidney Cahn, K. O’Sullivan, S. Shaw, T. P. Biesiadzinski, M. F. Marzioni, M. S. Witherell, B. P. Tennyson, M. C. Carmona-Benitez, Henrique Araujo, P. Beltrame, S. J. Haselschwardt, Matthew Szydagis, C. R. Hall, Daniel McKinsey, R. G. Jacobsen, W. Ji, K. Kamdin, D. S. Akerib, E. M. Boulton, T. J. Sumner, Dongming Mei, C. Ghag, A. St. J. Murphy, Adam Bernstein, M.I. Lopes, R. Knoche, Chao Zhang, D. P. Hogan, C. Rhyne, F. Neves, R. J. Gaitskell, J. E. Cutter, V. Velan, R. L. Mannino, and W. H. To
Subjects: Technology, Physics - Instrumentation and Detectors, Field (physics), Physics::Instrumentation and Detectors, Noble liquid detectors, FOS: Physical sciences, Electron, Detector modelling and simulations II, Noble liquid detectors (scintillation, ionization, double-phase), 01 natural sciences, High Energy Physics - Experiment, Dark Matter detectors (WIMPs, axions, etc.), High Energy Physics - Experiment (hep-ex), Engineering, Electric field, 0103 physical sciences, CALORIMETER, 010306 general physics, Dark Matter detectors, Instrumentation, Instruments & Instrumentation, physics.ins-det, Mathematical Physics, Mathematical physics, Physics, Science & Technology, 010308 nuclear & particles physics, hep-ex, Active volume, Mean value, Detector, Charge density, Instrumentation and Detectors (physics.ins-det), Computational Physics (physics.comp-ph), Nuclear & Particles Physics, Detector modelling and simulations II (electric fields, charge transport, multiplication and induction, pulse formation, electron emission, etc), LIGHT, physics.comp-ph, Physical Sciences, Analysis and statistical methods, Electric field magnitude, CHAMBERS, Physics - Computational Physics
Abstract: Author(s): Akerib, DS; Alsum, S; Araujo, HM; Bai, X; Bailey, AJ; Balajthy, J; Beltrame, P; Bernard, EP; Bernstein, A; Biesiadzinski, TP; Boulton, EM; Bras, P; Byram, D; Cahn, SB; Carmona-Benitez, MC; Chan, C; Currie, A; Cutter, JE; Davison, TJR; Dobi, A; Druszkiewicz, E; Edwards, BN; Fallon, SR; Fan, A; Fiorucci, S; Gaitskell, RJ; Genovesi, J; Ghag, C; Gilchriese, MGD; Hall, CR; Hanhardt, M; Haselschwardt, SJ; Hertel, SA; Hogan, DP; Horn, M; Huang, DQ; Ignarra, CM; Jacobsen, RG; Ji, W; Kamdin, K; Kazkaz, K; Khaitan, D; Knoche, R; Larsen, NA; Lenardo, BG; Lesko, KT; Lindote, A; Lopes, MI; Manalaysay, A; Mannino, RL; Marzioni, MF; McKinsey, DN; Mei, DM; Mock, J; Moongweluwan, M; Morad, JA; Murphy, ASJ; Nehrkorn, C; Nelson, HN; Neves, F; O'Sullivan, K; Oliver-Mallory, KC; Palladino, KJ; Pease, EK; Rhyne, C; Shaw, S; Shutt, TA; Silva, C; Solmaz, M; Solovov, VN; Sorensen, P; Sumner, TJ; Szydagis, M; Taylor, DJ; Taylor, WC; Tennyson, BP; Terman, PA; Tiedt, DR; To, WH; Tripathi, M; Tvrznikova, L; Uvarov, S; Velan, V; Verbus, JR; Webb, RC | Abstract: This work details the development of a three-dimensional (3D) electric field model for the LUX detector. The detector took data to search for weakly interacting massive particles (WIMPs) during two periods. After the first period completed, a time-varying non-uniform negative charge developed in the polytetrafluoroethylene (PTFE) panels that define the radial boundary of the detector's active volume. This caused electric field variations in the detector in time, depth and azimuth, generating an electrostatic radially-inward force on electrons on their way upward to the liquid surface. To map this behavior, 3D electric field maps of the detector's active volume were generated on a monthly basis. This was done by fitting a model built in COMSOL Multiphysics to the uniformly distributed calibration data that were collected on a regular basis. The modeled average PTFE charge density increased over the course of the exposure from -3.6 to -5.5 μC/m2. From our studies, we deduce that the electric field magnitude varied locally while the mean value of the field of ∼200 V/cm remained constant throughout the exposure. As a result of this work the varying electric fields and their impact on event reconstruction and discrimination were successfully modeled.
Published: 2017

20. First Searches for Axions and Axionlike Particles with the LUX Experiment

Author: K.R. Gibson, Henrique Araujo, P. A. Terman, S. Shaw, M. Hanhardt, C. R. Hall, S. Uvarov, D. P. Hogan, J. E. Cutter, M. Horn, A. Manalaysay, F.L.H. Wolfs, S. K. Young, M. S. Witherell, K. O’Sullivan, Ethan Bernard, M. C. Carmona-Benitez, D. J. Taylor, T. A. Shutt, F. Neves, R. G. Jacobsen, X. Bai, J. A. Morad, P. Brás, T. P. Biesiadzinski, J. E. Y. Dobson, K. Kamdin, J. T. White, M. G. D. Gilchriese, L. Tvrznikova, P. Beltrame, D. Q. Huang, W. Ji, C. Rhyne, S. Alsum, R. J. Gaitskell, A. Dobi, B. G. Lenardo, C. Aquino, A. Currie, S. J. Haselschwardt, M. Moongweluwan, H. N. Nelson, V. M. Gehman, V. Velan, Daniel McKinsey, T. J. Whitis, Matthew Szydagis, Dongming Mei, P. Sorensen, C. H. Faham, Jilei Xu, Sidney Cahn, K. T. Lesko, N. A. Larsen, K. Kazkaz, C. Nehrkorn, C. Ghag, M. Solmaz, J.R. Verbus, B. P. Tennyson, Mani Tripathi, S. Stephenson, R. L. Mannino, J. Mock, Chao Zhang, D. R. Tiedt, C. M. Ignarra, W. C. Taylor, R. C. Webb, A. Lindote, J. Balajthy, S. Fiorucci, L. Reichhart, S. R. Fallon, W. H. To, A. A. Chiller, C. Chan, B. N. Edwards, A. J. Bailey, A. St. J. Murphy, Adam Bernstein, M.I. Lopes, R. Knoche, D. S. Akerib, E. M. Boulton, T. J. Sumner, S. A. Hertel, E. Druszkiewicz, K. Yazdani, T. J. R. Davison, D. Byram, C. Chiller, K. J. Palladino, E. K. Pease, C. Silva, V. N. Solovov, K. C. Oliver-Mallory, Ching Hua Lee, M. F. Marzioni, and D. Khaitan
Subjects: Particle physics, General Physics, Large Underground Xenon experiment, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Physics, Multidisciplinary, General Physics and Astronomy, FOS: Physical sciences, Elementary particle, Astrophysics, 01 natural sciences, LUX Collaboration, High Energy Physics - Phenomenology (hep-ph), 0103 physical sciences, Invariant mass, 010306 general physics, Axion, DETECTOR, Boson, Physics, Coupling constant, HARMLESS AXION, Science & Technology, 02 Physical Sciences, 010308 nuclear & particles physics, INVISIBLE AXION, hep-ph, Coupling (probability), INVARIANCE, High Energy Physics - Phenomenology, STRONG CP PROBLEM, Physical Sciences, astro-ph.CO, Strong CP problem, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: The first searches for axions and axionlike particles with the Large Underground Xenon experiment are presented. Under the assumption of an axioelectric interaction in xenon, the coupling constant between axions and electrons g_{Ae} is tested using data collected in 2013 with an exposure totaling 95 live days ×118 kg. A double-sided, profile likelihood ratio statistic test excludes g_{Ae} larger than 3.5×10^{-12} (90% C.L.) for solar axions. Assuming the Dine-Fischler-Srednicki-Zhitnitsky theoretical description, the upper limit in coupling corresponds to an upper limit on axion mass of 0.12 eV/c^{2}, while for the Kim-Shifman-Vainshtein-Zhakharov description masses above 36.6 eV/c^{2} are excluded. For galactic axionlike particles, values of g_{Ae} larger than 4.2×10^{-13} are excluded for particle masses in the range 1-16 keV/c^{2}. These are the most stringent constraints to date for these interactions.
Published: 2017

21. Limits on spin-dependent WIMP-nucleon cross section obtained from the complete LUX exposure

Author: Jilei Xu, C. Nehrkorn, C. H. Faham, A. St. J. Murphy, C. Ghag, V. Velan, M.I. Lopes, F.L.H. Wolfs, R. Knoche, D. P. Hogan, A. Dobi, M. Hanhardt, E. M. Boulton, M. G. D. Gilchriese, D. Byram, T. J. Sumner, Sidney Cahn, T. J. Whitis, A. Bernstein, R. L. Mannino, S. Fiorucci, C. Chiller, H. N. Nelson, J. E. Cutter, F. Neves, A. J. Bailey, A. Manalaysay, Mani Tripathi, Matthew Szydagis, P. Brás, Ethan Bernard, W. H. To, D. Q. Huang, B. G. Lenardo, L. Tvrznikova, C. Chan, S. Uvarov, D. Khaitan, Daniel McKinsey, M. Horn, D. S. Akerib, M. Solmaz, S. R. Fallon, R. C. Webb, Dongming Mei, K. O’Sullivan, A. Currie, M. C. Carmona-Benitez, V. M. Gehman, K. Kamdin, K. J. Palladino, P. Beltrame, W. C. Taylor, K. Kazkaz, E. K. Pease, C. Silva, R. G. Jacobsen, S. A. Hertel, S. J. Haselschwardt, J. Balajthy, E. Druszkiewicz, K. Yazdani, V. N. Solovov, K. C. Oliver-Mallory, Chao Zhang, A. Lindote, L. Reichhart, S. Stephenson, Henrique Araujo, W. Ji, Ching Hua Lee, J.R. Verbus, A. A. Chiller, T. J. R. Davison, P. A. Terman, B. N. Edwards, T. P. Biesiadzinski, C. R. Hall, Sarah Young, D. R. Tiedt, C. M. Ignarra, J. T. White, P. Sorensen, B. P. Tennyson, C. Rhyne, R. J. Gaitskell, T. A. Shutt, J. A. Morad, J. E. Y. Dobson, K. T. Lesko, N. A. Larsen, S. Shaw, M. S. Witherell, X. Bai, J. Mock, D. J. Taylor, S. Alsum, M. Moongweluwan, and M. F. Marzioni
Subjects: Nuclear reaction, Particle physics, General Physics, Large Underground Xenon experiment, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Hadron, Physics, Multidisciplinary, General Physics and Astronomy, FOS: Physical sciences, Elementary particle, 01 natural sciences, Mathematical Sciences, LUX Collaboration, Nuclear physics, Engineering, WIMP, 0103 physical sciences, DARK-MATTER, 010306 general physics, Elastic scattering, Physics, Science & Technology, 02 Physical Sciences, 010308 nuclear & particles physics, Baryon, Physical Sciences, astro-ph.CO, Nucleon, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: We present experimental constraints on the spin-dependent WIMP-nucleon elastic cross sections from the total 129.5 kg-year exposure acquired by the Large Underground Xenon experiment (LUX), operating at the Sanford Underground Research Facility in Lead, South Dakota (USA). A profile likelihood ratio analysis allows 90% CL upper limits to be set on the WIMP-neutron (WIMP-proton) cross section of $\sigma_n$ = 1.6$\times 10^{-41}$ cm$^{2}$ ($\sigma_p$ = 5$\times 10^{-40}$ cm$^{2}$) at 35 GeV$c^{-2}$, almost a sixfold improvement over the previous LUX spin-dependent results. The spin-dependent WIMP-neutron limit is the most sensitive constraint to date., Comment: 7 pages, 3 figures, version accepted by PRL
Published: 2017
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22. Identification of Radiopure Titanium for the LZ Dark Matter Experiment and Future Rare Event Searches

Author: A.V. Khromov, P. Sorensen, D. Woodward, Duncan Carlsmith, M. Arthurs, J.S. Saba, Henrique Araujo, Yue Meng, M. G. D. Gilchriese, M. Horn, W. Skulski, S. A. Hertel, E. Druszkiewicz, E. H. Miller, D. White, C. Carels, K. Stifter, A. Manalaysay, L. Tvrznikova, M. S. Witherell, M. C. Carmona-Benitez, P. Rossiter, Laura Manenti, J. Va’vra, A. St. J. Murphy, B. Holbrook, C. R. Hall, B. Gomber, R. Coughlen, C. Levy, V.V. Sosnovtsev, Adam Bernstein, K. Kamdin, Ethan Bernard, T. J. R. Davison, J. J. Cherwinka, S. Hans, A. Currie, P.R. Scovell, P. Beltrame, E. Mizrachi, S. Fiorucci, K. J. Palladino, V. M. Gehman, Ben Carlson, T. J. Whitis, H. Kraus, R. W. Schnee, R. Bramante, M. Hoff, M.I. Lopes, I. J. Arnquist, J. Mock, W. R. Edwards, Carl W. Akerlof, D. J. Markley, J. Thomson, J. Yin, I. Olcina, F.L.H. Wolfs, K. Pushkin, S. J. Haselschwardt, H. J. Krebs, C. Chiller, S. Alsum, S. Shaw, M. G. D. van der Grinten, E. K. Pease, B. Lopez Paredes, S. Luitz, P. Brás, K. E. Boast, C. Silva, Elena Korolkova, A. Khazov, Andreas Piepke, T.J. Martin, W. L. Waldron, D. Q. Huang, A. Lindote, J. Belle, R.M. Gerhard, W.W. Craddock, T.W. Hurteau, K.J. Thomas, P. A. Terman, V. N. Solovov, D. Yu. Akimov, C. H. Faham, K. C. Oliver-Mallory, T.M. Stiegler, J. O'Dell, A. Cottle, B. Boxer, A. Konovalov, M. E. Monzani, W. C. Taylor, L. Reichhart, M.J. Barry, Juhyeong Lee, T. K. Edberg, C. Chan, I. Stancu, M. Timalsina, Wenzhao Wei, Michael Schubnell, D. Temples, D. J. Taylor, M. Solmaz, C. Ghag, R. M. Preece, S. Balashov, N.J. Gantos, R. G. Jacobsen, P. Majewski, M. Sarychev, R. Wang, J. Balajthy, K. Hanzel, H. S. Lee, Steven Worm, J. H. Buckley, A. J. Bailey, A. C. Kaboth, Matthew Szydagis, M. Koyuncu, J.R. Verbus, R. Bunker, W. H. Lippincott, Daniel McKinsey, T. Benson, A. V. Kumpan, Eric W. Hoppe, Antonin Vacheret, C. Hjemfelt, M.R. Stark, X. Bai, Minfang Yeh, B. N. Ratcliff, R. L. Mannino, T. Fruth, W. Ji, Seth Hillbrand, M. A. Olevitch, A. Richards, Jilei Xu, D. Khaitan, J. Lin, K. O’Sullivan, C. Nehrkorn, W. H. To, J. Reichenbacher, A. A. Chiller, J. A. Nikkel, W.T. Emmet, D. S. Akerib, R. Linehan, R. Watson, Mani Tripathi, David Leonard, Richard Rosero, J.P. Rodrigues, J. Busenitz, K. T. Lesko, C. Lee, C. Rhyne, R. J. Gaitskell, Kareem Kazkaz, Carl Vuosalo, T. P. Biesiadzinski, R. C. Webb, C. E. Dahl, T. J. Sumner, S. Kyre, F. Neves, R. Leonard, Wolfgang Lorenzon, H. J. Rose, S. Stephenson, Chao Zhang, W. J. Wisniewski, J.Y-K. Hor, Alexander Bolozdynya, V. Bugaev, Dongming Mei, F.-T. Liao, T. E. Tope, M. R. While, A. Dobi, H. N. Nelson, V. A. Kudryavtsev, S. Powell, D. R. Tiedt, B. J. Mount, T. A. Shutt, J. A. Morad, E. Holtom, J. E. Y. Dobson, C. M. Ignarra, C. T. McConnell, K. Skarpaas, M. F. Marzioni, A. Tomás, Sergey Burdin, X. Liu, and Science and Technology Facilities Council (STFC)
Subjects: Cryostat, Physics - Instrumentation and Detectors, ZEPLIN-III, Dark matter, chemistry.chemical_element, FOS: Physical sciences, Cryogenics, Astronomy & Astrophysics, 7. Clean energy, 01 natural sciences, Physics, Particles & Fields, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), Xenon, 0202 Atomic, Molecular, Nuclear, Particle And Plasma Physics, 0103 physical sciences, 010306 general physics, physics.ins-det, Physics, Science & Technology, 010308 nuclear & particles physics, hep-ex, Detector, Astronomy and Astrophysics, Instrumentation and Detectors (physics.ins-det), Nuclear & Particles Physics, 0201 Astronomical And Space Sciences, chemistry, 13. Climate action, Physical Sciences, Event (particle physics), Titanium, GERDA
Abstract: The LUX-ZEPLIN (LZ) experiment will search for dark matter particle interactions with a detector containing a total of 10 tonnes of liquid xenon within a double-vessel cryostat. The large mass and proximity of the cryostat to the active detector volume demand the use of material with extremely low intrinsic radioactivity. We report on the radioassay campaign conducted to identify suitable metals, the determination of factors limiting radiopure production, and the selection of titanium for construction of the LZ cryostat and other detector components. This titanium has been measured with activities of $^{238}$U$_{e}$~$, Comment: 13 pages, 3 figures, accepted for publication in Astroparticle Physics
Published: 2017
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23. Signal yields, energy resolution, and recombination fluctuations in liquid xenon

Author: Henrique Araujo, Jilei Xu, C. Nehrkorn, Matthew Szydagis, B. G. Lenardo, T. J. Sumner, C. R. Hall, M. C. Carmona-Benitez, M. Solmaz, K. Kamdin, Sidney Cahn, P. Beltrame, Mani Tripathi, K.R. Gibson, R.G. Jacobsen, D. Byram, S. Stephenson, M. F. Marzioni, A. Lindote, L. Reichhart, Witherell, R. C. Webb, K. O'Sullivan, Sarah Young, P. A. Terman, C. M. Ignarra, F.L.H. Wolfs, T. A. Shutt, N.A. Larsen, D. Q. Huang, J. A. Morad, Tiedt, Daniel McKinsey, J. E. Y. Dobson, S. J. Haselschwardt, S. Shaw, P. Brás, R. Bramante, P. Phelps, K. Kazkaz, A.A. Chiller, C. Chiller, B. P. Tennyson, D. Khaitan, M.I. Lopes, R. Knoche, C. H. Faham, K. J. Palladino, E. M. Boulton, M. Hanhardt, C. Ghag, E. K. Pease, C. Silva, D. M. Mei, V. N. Solovov, T. J. R. Davison, K. C. Oliver-Mallory, M. G. D. Gilchriese, A. Bernstein, S. Alsum, A. Dobi, A. Manalaysay, A. J. Bailey, B. N. Edwards, H. N. Nelson, L. Tvrznikova, M. Moongweluwan, D. P. Hogan, X. Bai, P. Sorensen, Ethan Bernard, M. Horn, R. L. Mannino, V. M. Gehman, F. Neves, J. Mock, Verbus, S. A. Hertel, E. Druszkiewicz, A. Currie, T. P. Biesiadzinski, M. Ihm, S. Uvarov, K. Yazdani, Chao Zhang, K. T. Lesko, C. Lee, C. Chan, W. Ji, T. J. Whitis, J. T. White, C. Rhyne, D. J. Taylor, R. J. Gaitskell, D. S. Akerib, A. Murphy, J. E. Cutter, W. C. Taylor, J. Balajthy, W. H. To, and S. Fiorucci
Subjects: Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, ARGON, chemistry.chemical_element, FOS: Physical sciences, Astronomy & Astrophysics, 01 natural sciences, Ion, High Energy Physics - Experiment, Physics, Particles & Fields, High Energy Physics - Experiment (hep-ex), Recoil, Xenon, DEPENDENCE, 0103 physical sciences, PARTICLES, 010306 general physics, Physics, Science & Technology, 010308 nuclear & particles physics, Resolution (electron density), Astrophysics::Instrumentation and Methods for Astrophysics, Limiting, Instrumentation and Detectors (physics.ins-det), SCINTILLATION YIELDS, 3. Good health, chemistry, Physical Sciences, IONIZATION, Atomic physics, Recombination
Abstract: This work presents an analysis of monoenergetic electronic recoil peaks in the dark-matter-search and calibration data from the first underground science run of the Large Underground Xenon (LUX) detector. Liquid xenon charge and light yields for electronic recoil energies between 5.2 and 661.7 keV are measured, as well as the energy resolution for the LUX detector at those same energies. Additionally, there is an interpretation of existing measurements and descriptions of electron-ion recombination fluctuations in liquid xenon as limiting cases of a more general liquid xenon re- combination fluctuation model. Measurements of the standard deviation of these fluctuations at monoenergetic electronic recoil peaks exhibit a linear dependence on the number of ions for energy deposits up to 661.7 keV, consistent with previous LUX measurements between 2-16 keV with $^3$H. We highlight similarities in liquid xenon recombination for electronic and nuclear recoils with a comparison of recombination fluctuations measured with low-energy calibration data., 11 pages, 12 figures, 3 tables
Published: 2017

24. FPGA-based Trigger System for the LUX Dark Matter Experiment

Author: J. E. Cutter, C. Rhyne, R. J. Gaitskell, C. H. Faham, C. Ghag, B. Lenardo, Mani Tripathi, M. Pangilinan, M. C. Carmona-Benitez, W. Skulski, S. Shaw, L. de Viveiros, M. Hanhardt, P. Phelps, W. H. To, P. A. Terman, D. M. Mei, A. Bernstein, P. Beltrame, T. J. R. Davison, T. P. Biesiadzinski, A. Currie, A. J. Bailey, A. Manalaysay, A. W. Bradley, S. A. Hertel, D. P. Hogan, X. Bai, R. C. Webb, A. Dobi, M. G. D. Gilchriese, E. Druszkiewicz, C. Chan, Ethan Bernard, J. Yin, Sidney Cahn, H. N. Nelson, F. Neves, T. J. Whitis, J. Mock, B. N. Edwards, S. J. Haselschwardt, J. T. White, Matthew Szydagis, Michael S. Witherell, Chao Zhang, C. Nehrkorn, W. C. Taylor, J. Balajthy, K. T. Lesko, C. Lee, W. Ji, R. A. Ott, F.L.H. Wolfs, A. Lindote, K.R. Gibson, L. Reichhart, T. A. Shutt, J. A. Morad, J.J. Chapman, J. E. Y. Dobson, Sarah Young, D. J. Taylor, Daniel McKinsey, N.A. Larsen, R. Bramante, D. R. Tiedt, C. M. Ignarra, J.R. Verbus, S. Fiorucci, A.A. Chiller, E. M. Boulton, M. F. Marzioni, D.C. Malling, K. Kazkaz, C. Chiller, Henrique Araujo, M. Moongweluwan, C. R. Hall, R.G. Jacobsen, D. S. Akerib, T. J. Sumner, S. Stephenson, D. Q. Huang, A. St. J. Murphy, K. J. Palladino, E. K. Pease, C. Silva, V. N. Solovov, K. C. Oliver-Mallory, M.I. Lopes, R. Knoche, M. Ihm, B. P. Tennyson, D. Khaitan, S. Uvarov, K. O׳Sullivan, M. Horn, L. Tvrznikova, V. M. Gehman, R. L. Mannino, and P. Sorensen
Subjects: Technology, Nuclear and High Energy Physics, Physics - Instrumentation and Detectors, Dark matter, Latency (audio), FOS: Physical sciences, chemistry.chemical_element, 7. Clean energy, 01 natural sciences, Physics, Particles & Fields, Nuclear physics, 0202 Atomic, Molecular, Nuclear, Particle And Plasma Physics, Data acquisition, Xenon, Optics, 0103 physical sciences, Nuclear Science & Technology, DSP, 010306 general physics, Instruments & Instrumentation, Instrumentation, Spectroscopy, FPGA, Digital signal processing, Physics, Dark matter detectors, Science & Technology, Time projection chamber, 010308 nuclear & particles physics, business.industry, Detector, Baseline subtraction, Instrumentation and Detectors (physics.ins-det), Nuclear & Particles Physics, DAQ, Trigger, Microsecond, chemistry, Physical Sciences, business
Abstract: LUX is a two-phase (liquid/gas) xenon time projection chamber designed to detect nuclear recoils resulting from interactions with dark matter particles. Signals from the detector are processed with an FPGA-based digital trigger system that analyzes the incoming data in real-time, with just a few microsecond latency. The system enables first pass selection of events of interest based on their pulse shape characteristics and 3D localization of the interactions. It has been shown to be >99% efficient in triggering on S2 signals induced by only few extracted liquid electrons. It is continuously and reliably operating since its full underground deployment in early 2013. This document is an overview of the systems capabilities, its inner workings, and its performance., 11 pages, 26 figures, added some key points to the abstract, and conclusions, no change in results, accepted for publication in Nuclear Instruments and Methods in Physics Research Section A
Published: 2016

25. LUX-ZEPLIN (LZ) Conceptual Design Report

Author: V. B. Francis, A. Bernstein, A. Manalaysay, C. Chan, C. E. Tull, Eli Woods, B. N. Ratcliff, Ethan Bernard, R. W. Schnee, N.A. Larsen, V.V. Sosnovtsev, Elena Korolkova, M. Sarychev, James Nikkel, J. J. Cherwinka, S. Luitz, Peter Majewski, J.S. Saba, Henrique Araujo, D. White, B. N. Edwards, W. H. Lippincott, F. G. O'Neill, A. Khazov, X. Ji, M. E. Monzani, B. Holbrook, K. O'Sullivan, Laura Manenti, J. Liu, P.R. Scovell, D.C. Malling, E. M. Boulton, M. G. D. van der Grinten, W.L. Waldron, W. C. Taylor, D. S. Akerib, C. R. Hall, Mikkel B. Johnson, F.L.H. Wolfs, J. Lin, Matthew Szydagis, J. Balajthy, K. J. Palladino, T. P. Biesiadzinski, H. Kraus, A. Currie, C. E. Dahl, R. Bunker, E. K. Pease, C. Silva, V. N. Solovov, J. Thomson, M. R. While, A. Dobi, H. N. Nelson, T. J. Sumner, K. C. Oliver-Mallory, W. H. To, I. Stancu, S. Stephenson, M. Pangilinan, T. J. Whitis, R. Bramante, K. E. Boast, T.J. Martin, L. Tvrznikova, A. Lindote, Patrick Bauer, J. O'Dell, L. Wang, D. Woodward, V. A. Kudryavtsev, H.J. Krebs, M. Elnimr, D. R. Tiedt, J.P. Rodrigues, J. Busenitz, Hoff, S. Kyre, F. Neves, L. Reichhart, C. Fu, Wolfgang Lorenzon, C. Rhyne, W. J. Wisniewski, M.J. Barry, C. M. Ignarra, M. C. Carmona-Benitez, W. Skulski, W. R. Edwards, Carl W. Akerlof, R. J. Gaitskell, S. Balashov, Michael Schubnell, Olevitch, S. J. Patton, B. P. Tennyson, M. F. Marzioni, D. Khaitan, R. L. Mannino, K. Kamdin, W. Craddock, S. D. Worm, V. M. Gehman, Y. Ju, A. J. Bailey, Daniel McKinsey, B. G. Lenardo, P. Beltrame, H. J. Rose, Minfang Yeh, Sergey Burdin, R.M. Gerhard, X. Liu, K. Skarpaas, S. A. Hertel, E. Druszkiewicz, A. St. J. Murphy, T.M. Stiegler, T.W. Hurteau, K.J. Thomas, J. Yin, A. Tomás, K. Kazkaz, C. Chiller, S. Powell, M. Cascella, T. J. R. Davison, Chao Zhang, A.A. Chiller, T. A. Shutt, J. A. Morad, J. Reichenbacher, J. E. Y. Dobson, R. M. Preece, N.J. Gantos, S. J. Haselschwardt, S. Uvarov, S.K. Young, M. G. D. Gilchriese, M.I. Lopes, Ben Carlson, J. Va’vra, J. E. Cutter, A.V. Khromov, C. Carels, Alexander Bolozdynya, V. Bugaev, R.G. Jacobsen, A. Harris, Wenzhao Wei, D. J. Taylor, D.Yu. Akimov, Dongming Mei, Duncan Carlsmith, Witherell, E. Holtom, W. Ji, C. H. Faham, S. Alsum, F.-T. Liao, D. Q. Huang, C. Ghag, C. O. Vuosalo, Bhawna Gomber, Mani Tripathi, Richard Rosero, R. C. Webb, L. de Viveiros, W. T. Emmet, Sridhara Dasu, S. Fiorucci, J.P. da Cunha, P. A. Terman, X. Bai, D. Markley, J. Mock, A. V. Kumpan, M.R. Stark, P. Sorensen, Yue Meng, K. T. Lesko, C. Lee, E. H. Miller, S. Shaw, A. Piepke, K. Sundarnath, A. Konovalov, T. K. Edberg, K. Pushkin, P. Ford, J. H. Buckley, and J.R. Verbus
Subjects: Physics, Particle physics, Expected cost, hep-ex, 010308 nuclear & particles physics, Technical systems, Detector, 01 natural sciences, 7. Clean energy, Particle detector, Nuclear physics, Conceptual design, Weakly interacting massive particles, 0103 physical sciences, 010306 general physics, physics.ins-det, astro-ph.IM
Abstract: The design and performance of the LUX-ZEPLIN (LZ) detector is described as of March 2015 in this Conceptual Design Report. LZ is a second-generation dark-matter detector with the potential for unprecedented sensitivity to weakly interacting massive particles (WIMPs) of masses from a few GeV/c2 to hundreds of TeV/c2. With total liquid xenon mass of about 10 tonnes, LZ will be the most sensitive experiment for WIMPs in this mass region by the end of the decade. This report describes in detail the design of the LZ technical systems. Expected backgrounds are quantified and the performance of the experiment is presented. The LZ detector will be located at the Sanford Underground Research Facility in South Dakota. The organization of the LZ Project and a summary of the expected cost and current schedule are given.
Published: 2015
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26. Results from a Search for Dark Matter in the Complete LUX Exposure

Author: M. Hanhardt, K.R. Gibson, A. Bernstein, E. M. Boulton, A. Manalaysay, W. H. To, T. J. Sumner, Ethan Bernard, M. G. D. Gilchriese, R. Bramante, R.G. Jacobsen, X. Bai, Matthew Szydagis, Sidney Cahn, B. P. Tennyson, D. Khaitan, Henrique Araujo, J.R. Verbus, Jilei Xu, C. Nehrkorn, J. Mock, A. St. J. Murphy, D. Q. Huang, S. Stephenson, D. J. Taylor, C. Chan, L. Tvrznikova, C. R. Hall, B. G. Lenardo, Sarah Young, M. F. Marzioni, D. R. Tiedt, D. Byram, C. M. Ignarra, M.I. Lopes, M. Ihm, S. Shaw, R. Knoche, S. Uvarov, P. Phelps, R. L. Mannino, S. J. Haselschwardt, J. T. White, K. O’Sullivan, M. Horn, M. S. Witherell, V. M. Gehman, Daniel McKinsey, N.A. Larsen, S. Alsum, B. N. Edwards, T. P. Biesiadzinski, F.L.H. Wolfs, P. Brás, M. Moongweluwan, K. J. Palladino, W. Ji, P. A. Terman, S. A. Hertel, K. Kazkaz, E. Druszkiewicz, C. Chiller, K. Yazdani, S. Fiorucci, M. C. Carmona-Benitez, E. K. Pease, C. Silva, V. N. Solovov, K. Kamdin, P. Beltrame, Mani Tripathi, K. C. Oliver-Mallory, W. C. Taylor, D. S. Akerib, J. Balajthy, D. M. Mei, P. Sorensen, T. J. R. Davison, R. C. Webb, C. H. Faham, C. Ghag, M. Solmaz, J. E. Cutter, A. Lindote, L. Reichhart, T. A. Shutt, J. A. Morad, J. E. Y. Dobson, A. J. Bailey, C. Rhyne, A. Dobi, H. N. Nelson, A.A. Chiller, A. Currie, T. J. Whitis, R. J. Gaitskell, D. P. Hogan, F. Neves, Chao Zhang, K. T. Lesko, C. Lee, and Science and Technology Facilities Council (STFC)
Subjects: General Physics, Physics - Instrumentation and Detectors, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Dark matter, Physics, Multidisciplinary, Massive particle, General Physics and Astronomy, chemistry.chemical_element, FOS: Physical sciences, 01 natural sciences, 09 Engineering, High Energy Physics - Experiment, LUX Collaboration, Nuclear physics, High Energy Physics - Experiment (hep-ex), Xenon, WIMP, 0103 physical sciences, Sensitivity (control systems), 010306 general physics, physics.ins-det, Instrumentation and Methods for Astrophysics (astro-ph.IM), 01 Mathematical Sciences, Physics, Time projection chamber, Science & Technology, 02 Physical Sciences, 010308 nuclear & particles physics, Scattering, hep-ex, Instrumentation and Detectors (physics.ins-det), chemistry, Physical Sciences, astro-ph.CO, CHAMBERS, PandaX, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics, astro-ph.IM
Abstract: We report constraints on spin-independent weakly interacting massive particle (WIMP)-nucleon scattering using a 3.35e4 kg-day exposure of the Large Underground Xenon (LUX) experiment. A dual-phase xenon time projection chamber with 250 kg of active mass is operated at the Sanford Underground Research Facility under Lead, South Dakota (USA). With roughly fourfold improvement in sensitivity for high WIMP masses relative to our previous results, this search yields no evidence of WIMP nuclear recoils. At a WIMP mass of 50 GeV/c^2, WIMP-nucleon spin-independent cross sections above 2.2e-46 cm^2 are excluded at the 90% confidence level. When combined with the previously reported LUX exposure, this exclusion strengthens to 1.1e-46 cm^2 at 50 GeV/c^2., Comment: This version includes a combined analysis with previously published LUX results, and matches the version published in PRL
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27. Calibration, event reconstruction, data analysis, and limit calculation for the LUX dark matter experiment

Author: L. Tvrznikova, S. Shaw, W. Ji, J. E. Cutter, A. Currie, V. Velan, A. Dobi, H. N. Nelson, A. Lindote, L. Reichhart, M. G. D. Gilchriese, D. Byram, A. J. Bailey, T. P. Biesiadzinski, P. Brás, X. Bai, K. Kazkaz, M. Horn, Matthew Szydagis, Daniel McKinsey, C. Rhyne, R. J. Gaitskell, J. Mock, S. Fiorucci, E. M. Boulton, R. L. Mannino, Chao Zhang, M. C. Carmona-Benitez, T. A. Shutt, Sarah Young, C. H. Faham, D. R. Tiedt, Blair Edwards, Henrique Araujo, C. M. Ignarra, J. A. Morad, J. E. Y. Dobson, B. G. Lenardo, K. Kamdin, T. J. Whitis, C. Ghag, P. Beltrame, C. R. Hall, K. T. Lesko, N. A. Larsen, J.R. Verbus, T. J. Sumner, Sidney Cahn, D. P. Hogan, S. J. Haselschwardt, J. Genovesi, Jilei Xu, M. Solmaz, C. Nehrkorn, Dongming Mei, Ching Hua Lee, D. J. Taylor, T. J. R. Davison, M. F. Marzioni, D. Q. Huang, F. Neves, J. T. White, Mani Tripathi, D. S. Akerib, R. C. Webb, A. St. J. Murphy, Adam Bernstein, S. Uvarov, M.I. Lopes, R. Knoche, M. Hanhardt, V.M. Gehman, A. Manalaysay, D. Khaitan, S. R. Fallon, Ethan Bernard, Michael S. Witherell, K. J. Palladino, S. Alsum, M. Moongweluwan, E. K. Pease, C. Silva, V. N. Solovov, K. C. Oliver-Mallory, W. H. To, C. Chan, A. Fan, K. O'Sullivan, F.L.H. Wolfs, W. C. Taylor, P. Sorensen, J. Balajthy, B. P. Tennyson, P. A. Terman, S. A. Hertel, E. Druszkiewicz, K. Yazdani, and R. G. Jacobsen
Subjects: SIMULATION TOOLKIT, Photomultiplier, Physics - Instrumentation and Detectors, Photon, Dark matter, FOS: Physical sciences, chemistry.chemical_element, Bioengineering, Astronomy & Astrophysics, Atomic, 01 natural sciences, Physics, Particles & Fields, Particle and Plasma Physics, Optics, Xenon, Affordable and Clean Energy, 0103 physical sciences, Calibration, SCATTERING, Nuclear, 010306 general physics, DETECTOR, physics.ins-det, Event reconstruction, NOBLE-GASES, Physics, Quantum Physics, Scintillation, Science & Technology, 010308 nuclear & particles physics, business.industry, Scattering, 2-PHASE XENON, Astrophysics::Instrumentation and Methods for Astrophysics, LIQUID XENON, Molecular, Instrumentation and Detectors (physics.ins-det), Nuclear & Particles Physics, MODEL, chemistry, Physical Sciences, IONIZATION, ELECTRON-EMISSION, SCINTILLATION, business, Astronomical and Space Sciences
Abstract: The LUX experiment has performed searches for dark matter particles scattering elastically on xenon nuclei, leading to stringent upper limits on the nuclear scattering cross sections for dark matter. Here, for results derived from ${1.4}\times 10^{4}\;\mathrm{kg\,days}$ of target exposure in 2013, details of the calibration, event-reconstruction, modeling, and statistical tests that underlie the results are presented. Detector performance is characterized, including measured efficiencies, stability of response, position resolution, and discrimination between electron- and nuclear-recoil populations. Models are developed for the drift field, optical properties, background populations, the electron- and nuclear-recoil responses, and the absolute rate of low-energy background events. Innovations in the analysis include in situ measurement of the photomultipliers' response to xenon scintillation photons, verification of fiducial mass with a low-energy internal calibration source, and new empirical models for low-energy signal yield based on large-sample, in situ calibrations.
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28. SNEWS 2.0 : a next-generation supernova early warning system for multi-messenger astronomy

Author: M. Clark, James P. Kneller, A. Depoian, R. F. Lang, A. Gallo Rosso, M. Colomer-Molla, J. Vasel, Richard Hill, B. W. Pointon, V. Fischer, E. Caden, M. Lai, C. D. Tunnell, Matthew L Strait, A. Higuera, Volodymyr Takhistov, B. Viren, J. S. Wang, Lindley Winslow, M. Lincetto, Y. Xu, A. L. Renshaw, S. Y. BenZvi, E. Katsavounidis, A. Coleiro, A. J. Roeth, Jake S. Bobowski, D. Franco, T. Sonley, Carlo Vigorito, F. L. H. Wolfs, C. J. Virtue, A. Sheshukov, S. Griswold, J. I. Crespo-Anadón, A. Kopec, G. Pagliaroli, W. Fulgione, O. Halim, D. Khaitan, Koji Ishidoshiro, Kate Scholberg, C. Kato, M. Geske, Dan Milisavljevic, H. L. Li, E. O. Connor, R. Peres, Shunsaku Horiuchi, M. Gromov, E. O. Sullivan, T. Brunner, Nirmal Raj, J. Migenda, Alec Habig, S. Al Kharusi, J. C.L. Tseng, D. Dornic, J. Rumleskie, V. Brdar, L. J. Wen, J. Qin, Daryl Haggard, V. Kulikovskiy, D. A. Patel, M. Lamoureux, Cecilia Lunardini, M. E. McCarthy, X. J. Xu, W. Bonivento, Irene Tamborra, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), SNEWS, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)
Subjects: Milky Way, Astrophysics::High Energy Astrophysical Phenomena, satellite, FOS: Physical sciences, General Physics and Astronomy, 01 natural sciences, High Energy Physics - Experiment, 010305 fluids & plasmas, High Energy Physics - Experiment (hep-ex), Astronomi, astrofysik och kosmologi, star, 0103 physical sciences, supernova, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Astronomy, Astrophysics and Cosmology, 010306 general physics, supernova neutrinos, capture, Astrophysics::Galaxy Astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Astroparticle physics, Physics, Warning system, Supernova Early Warning System, background, Astronomy, sensitivity, Galaxy, Supernova, electromagnetic, Neutrino detector, multi-messenger astronomy, particle astrophysics, neutrino: burst, galaxy, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: The next core-collapse supernova in the Milky Way or its satellites will represent a once-in-a-generation opportunity to obtain detailed information about the explosion of a star and provide significant scientific insight for a variety of fields because of the extreme conditions found within. Supernovae in our galaxy are not only rare on a human timescale but also happen at unscheduled times, so it is crucial to be ready and use all available instruments to capture all possible information from the event. The first indication of a potential stellar explosion will be the arrival of a bright burst of neutrinos. Its observation by multiple detectors worldwide can provide an early warning for the subsequent electromagnetic fireworks, as well as signal to other detectors with significant backgrounds so they can store their recent data. The Supernova Early Warning System (SNEWS) has been operating as a simple coincidence between neutrino experiments in automated mode since 2005. In the current era of multi-messenger astronomy there are new opportunities for SNEWS to optimize sensitivity to science from the next Galactic supernova beyond the simple early alert. This document is the product of a workshop in June 2019 towards design of SNEWS 2.0, an upgraded SNEWS with enhanced capabilities exploiting the unique advantages of prompt neutrino detection to maximize the science gained from such a valuable event., Comment: 66 pages, 11 figures
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29. SNEWS 2.0: a next-generation supernova early warning system for multi-messenger astronomy

Author: S Al Kharusi, S Y BenZvi, J S Bobowski, W Bonivento, V Brdar, T Brunner, E Caden, M Clark, A Coleiro, M Colomer-Molla, J I Crespo-Anadón, A Depoian, D Dornic, V Fischer, D Franco, W Fulgione, A Gallo Rosso, M Geske, S Griswold, M Gromov, D Haggard, A Habig, O Halim, A Higuera, R Hill, S Horiuchi, K Ishidoshiro, C Kato, E Katsavounidis, D Khaitan, J P Kneller, A Kopec, V Kulikovskiy, M Lai, M Lamoureux, R F Lang, H L Li, M Lincetto, C Lunardini, J Migenda, D Milisavljevic, M E McCarthy, E O Connor, E O Sullivan, G Pagliaroli, D Patel, R Peres, B W Pointon, J Qin, N Raj, A Renshaw, A Roeth, J Rumleskie, K Scholberg, A Sheshukov, T Sonley, M Strait, V Takhistov, I Tamborra, J Tseng, C D Tunnell, J Vasel, C F Vigorito, B Viren, C J Virtue, J S Wang, L J Wen, L Winslow, F L H Wolfs, X J Xu, and Y Xu
Subjects: supernova neutrinos, multi-messenger astronomy, particle astrophysics, Science, Physics, QC1-999
Abstract: The next core-collapse supernova in the Milky Way or its satellites will represent a once-in-a-generation opportunity to obtain detailed information about the explosion of a star and provide significant scientific insight for a variety of fields because of the extreme conditions found within. Supernovae in our galaxy are not only rare on a human timescale but also happen at unscheduled times, so it is crucial to be ready and use all available instruments to capture all possible information from the event. The first indication of a potential stellar explosion will be the arrival of a bright burst of neutrinos. Its observation by multiple detectors worldwide can provide an early warning for the subsequent electromagnetic fireworks, as well as signal to other detectors with significant backgrounds so they can store their recent data. The supernova early warning system (SNEWS) has been operating as a simple coincidence between neutrino experiments in automated mode since 2005. In the current era of multi-messenger astronomy there are new opportunities for SNEWS to optimize sensitivity to science from the next galactic supernova beyond the simple early alert. This document is the product of a workshop in June 2019 towards design of SNEWS 2.0, an upgraded SNEWS with enhanced capabilities exploiting the unique advantages of prompt neutrino detection to maximize the science gained from such a valuable event.
Published: 2021
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30. Constraints on Covariant Dark-Matter-Nucleon Effective Field Theory Interactions from the First Science Run of the LUX-ZEPLIN Experiment.

Author: Aalbers J, Akerib DS, Al Musalhi AK, Alder F, Amarasinghe CS, Ames A, Anderson TJ, Angelides N, Araújo HM, Armstrong JE, Arthurs M, Baker A, Balashov S, Bang J, Barillier EE, Bargemann JW, Beattie K, Benson T, Bhatti A, Biekert A, Biesiadzinski TP, Birch HJ, Bishop EJ, Blockinger GM, Boxer B, Brew CAJ, Brás P, Burdin S, Buuck M, Carmona-Benitez MC, Carter M, Chawla A, Chen H, Cherwinka JJ, Chin YT, Chott NI, Converse MV, Cottle A, Cox G, Curran D, Dahl CE, David A, Delgaudio J, Dey S, de Viveiros L, Di Felice L, Ding C, Dobson JEY, Druszkiewicz E, Eriksen SR, Fan A, Fearon NM, Fiorucci S, Flaecher H, Fraser ED, Fruth TMA, Gaitskell RJ, Geffre A, Genovesi J, Ghag C, Gibbons R, Gokhale S, Green J, van der Grinten MGD, Haiston JJ, Hall CR, Han S, Hartigan-O'Connor E, Haselschwardt SJ, Hernandez MA, Hertel SA, Heuermann G, Homenides GJ, Horn M, Huang DQ, Hunt D, Jacquet E, James RS, Johnson J, Kaboth AC, Kamaha AC, Kannichankandy M, Khaitan D, Khazov A, Khurana I, Kim JD, Kim J, Kingston J, Kirk R, Kodroff D, Korley L, Korolkova EV, Kraus H, Kravitz S, Kreczko L, Kudryavtsev VA, Leonard DS, Lesko KT, Levy C, Lin J, Lindote A, Linehan R, Lippincott WH, Lopes MI, Lorenzon W, Lu C, Luitz S, Majewski PA, Manalaysay A, Mannino RL, Maupin C, McCarthy ME, McDowell G, McKinsey DN, McLaughlin J, McLaughlin JB, McMonigle R, Miller EH, Mizrachi E, Monte A, Monzani ME, Morales Mendoza JD, Morrison E, Mount BJ, Murdy M, Murphy ASJ, Naylor A, Nelson HN, Neves F, Nguyen A, Nikoleyczik JA, Olcina I, Oliver-Mallory KC, Orpwood J, Palladino KJ, Palmer J, Pannifer NJ, Parveen N, Patton SJ, Penning B, Pereira G, Perry E, Pershing T, Piepke A, Qie Y, Reichenbacher J, Rhyne CA, Riffard Q, Rischbieter GRC, Riyat HS, Rosero R, Rushton T, Rynders D, Santone D, Sazzad ABMR, Schnee RW, Shaw S, Shutt T, Silk JJ, Silva C, Sinev G, Siniscalco J, Smith R, Solovov VN, Sorensen P, Soria J, Stancu I, Stevens A, Stifter K, Suerfu B, Sumner TJ, Szydagis M, Taylor WC, Tiedt DR, Timalsina M, Tong Z, Tovey DR, Tranter J, Trask M, Tripathi M, Tronstad DR, Vacheret A, Vaitkus AC, Valentino O, Velan V, Wang A, Wang JJ, Wang Y, Watson JR, Webb RC, Weeldreyer L, Whitis TJ, Williams M, Wisniewski WJ, Wolfs FLH, Woodford S, Woodward D, Wright CJ, Xia Q, Xiang X, Xu J, Yeh M, and Zweig EA
Abstract: The LUX-ZEPLIN (LZ) experiment is a dual-phase xenon time project chamber operating in the Sanford Underground Research Facility in South Dakota, USA. We report on the results of a relativistic extension to the nonrelativistic effective field theory (NREFT) from a 5.5 t fiducial mass and 60 live days of exposure. We present constraints on couplings from covariant interactions arising from the coupling of vector, axial currents, and electric dipole moments of the nucleon to the magnetic and electric dipole moments of the weakly interacting massive particle which cannot be described by recasting previous results described by an NREFT. Using a profile-likelihood ratio analysis, in an energy region between 0 keV_{nr} to 270 keV_{nr}, we report 90% confidence level exclusion limits on the coupling strength of five interactions in both the isoscalar and isovector bases.
Published: 2024
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31. First Dark Matter Search Results from the LUX-ZEPLIN (LZ) Experiment.

Author: Aalbers J, Akerib DS, Akerlof CW, Al Musalhi AK, Alder F, Alqahtani A, Alsum SK, Amarasinghe CS, Ames A, Anderson TJ, Angelides N, Araújo HM, Armstrong JE, Arthurs M, Azadi S, Bailey AJ, Baker A, Balajthy J, Balashov S, Bang J, Bargemann JW, Barry MJ, Barthel J, Bauer D, Baxter A, Beattie K, Belle J, Beltrame P, Bensinger J, Benson T, Bernard EP, Bhatti A, Biekert A, Biesiadzinski TP, Birch HJ, Birrittella B, Blockinger GM, Boast KE, Boxer B, Bramante R, Brew CAJ, Brás P, Buckley JH, Bugaev VV, Burdin S, Busenitz JK, Buuck M, Cabrita R, Carels C, Carlsmith DL, Carlson B, Carmona-Benitez MC, Cascella M, Chan C, Chawla A, Chen H, Cherwinka JJ, Chott NI, Cole A, Coleman J, Converse MV, Cottle A, Cox G, Craddock WW, Creaner O, Curran D, Currie A, Cutter JE, Dahl CE, David A, Davis J, Davison TJR, Delgaudio J, Dey S, de Viveiros L, Dobi A, Dobson JEY, Druszkiewicz E, Dushkin A, Edberg TK, Edwards WR, Elnimr MM, Emmet WT, Eriksen SR, Faham CH, Fan A, Fayer S, Fearon NM, Fiorucci S, Flaecher H, Ford P, Francis VB, Fraser ED, Fruth T, Gaitskell RJ, Gantos NJ, Garcia D, Geffre A, Gehman VM, Genovesi J, Ghag C, Gibbons R, Gibson E, Gilchriese MGD, Gokhale S, Gomber B, Green J, Greenall A, Greenwood S, van der Grinten MGD, Gwilliam CB, Hall CR, Hans S, Hanzel K, Harrison A, Hartigan-O'Connor E, Haselschwardt SJ, Hernandez MA, Hertel SA, Heuermann G, Hjemfelt C, Hoff MD, Holtom E, Hor JY, Horn M, Huang DQ, Hunt D, Ignarra CM, Jacobsen RG, Jahangir O, James RS, Jeffery SN, Ji W, Johnson J, Kaboth AC, Kamaha AC, Kamdin K, Kasey V, Kazkaz K, Keefner J, Khaitan D, Khaleeq M, Khazov A, Khurana I, Kim YD, Kocher CD, Kodroff D, Korley L, Korolkova EV, Kras J, Kraus H, Kravitz S, Krebs HJ, Kreczko L, Krikler B, Kudryavtsev VA, Kyre S, Landerud B, Leason EA, Lee C, Lee J, Leonard DS, Leonard R, Lesko KT, Levy C, Li J, Liao FT, Liao J, Lin J, Lindote A, Linehan R, Lippincott WH, Liu R, Liu X, Liu Y, Loniewski C, Lopes MI, Lopez Asamar E, López Paredes B, Lorenzon W, Lucero D, Luitz S, Lyle JM, Majewski PA, Makkinje J, Malling DC, Manalaysay A, Manenti L, Mannino RL, Marangou N, Marzioni MF, Maupin C, McCarthy ME, McConnell CT, McKinsey DN, McLaughlin J, Meng Y, Migneault J, Miller EH, Mizrachi E, Mock JA, Monte A, Monzani ME, Morad JA, Morales Mendoza JD, Morrison E, Mount BJ, Murdy M, Murphy ASJ, Naim D, Naylor A, Nedlik C, Nehrkorn C, Neves F, Nguyen A, Nikoleyczik JA, Nilima A, O'Dell J, O'Neill FG, O'Sullivan K, Olcina I, Olevitch MA, Oliver-Mallory KC, Orpwood J, Pagenkopf D, Pal S, Palladino KJ, Palmer J, Pangilinan M, Parveen N, Patton SJ, Pease EK, Penning B, Pereira C, Pereira G, Perry E, Pershing T, Peterson IB, Piepke A, Podczerwinski J, Porzio D, Powell S, Preece RM, Pushkin K, Qie Y, Ratcliff BN, Reichenbacher J, Reichhart L, Rhyne CA, Richards A, Riffard Q, Rischbieter GRC, Rodrigues JP, Rodriguez A, Rose HJ, Rosero R, Rossiter P, Rushton T, Rutherford G, Rynders D, Saba JS, Santone D, Sazzad ABMR, Schnee RW, Scovell PR, Seymour D, Shaw S, Shutt T, Silk JJ, Silva C, Sinev G, Skarpaas K, Skulski W, Smith R, Solmaz M, Solovov VN, Sorensen P, Soria J, Stancu I, Stark MR, Stevens A, Stiegler TM, Stifter K, Studley R, Suerfu B, Sumner TJ, Sutcliffe P, Swanson N, Szydagis M, Tan M, Taylor DJ, Taylor R, Taylor WC, Temples DJ, Tennyson BP, Terman PA, Thomas KJ, Tiedt DR, Timalsina M, To WH, Tomás A, Tong Z, Tovey DR, Tranter J, Trask M, Tripathi M, Tronstad DR, Tull CE, Turner W, Tvrznikova L, Utku U, Va'vra J, Vacheret A, Vaitkus AC, Verbus JR, Voirin E, Waldron WL, Wang A, Wang B, Wang JJ, Wang W, Wang Y, Watson JR, Webb RC, White A, White DT, White JT, White RG, Whitis TJ, Williams M, Wisniewski WJ, Witherell MS, Wolfs FLH, Wolfs JD, Woodford S, Woodward D, Worm SD, Wright CJ, Xia Q, Xiang X, Xiao Q, Xu J, Yeh M, Yin J, Young I, Zarzhitsky P, Zuckerman A, and Zweig EA
Abstract: The LUX-ZEPLIN experiment is a dark matter detector centered on a dual-phase xenon time projection chamber operating at the Sanford Underground Research Facility in Lead, South Dakota, USA. This Letter reports results from LUX-ZEPLIN's first search for weakly interacting massive particles (WIMPs) with an exposure of 60 live days using a fiducial mass of 5.5 t. A profile-likelihood ratio analysis shows the data to be consistent with a background-only hypothesis, setting new limits on spin-independent WIMP-nucleon, spin-dependent WIMP-neutron, and spin-dependent WIMP-proton cross sections for WIMP masses above 9 GeV/c^{2}. The most stringent limit is set for spin-independent scattering at 36 GeV/c^{2}, rejecting cross sections above 9.2×10^{-48} cm at the 90% confidence level.
Published: 2023
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32. Results of a Search for Sub-GeV Dark Matter Using 2013 LUX Data.

Author: Akerib DS, Alsum S, Araújo HM, Bai X, Balajthy J, Beltrame P, Bernard EP, Bernstein A, Biesiadzinski TP, Boulton EM, Boxer B, Brás P, Burdin S, Byram D, Carmona-Benitez MC, Chan C, Cutter JE, Davison TJR, Druszkiewicz E, Fallon SR, Fan A, Fiorucci S, Gaitskell RJ, Genovesi J, Ghag C, Gilchriese MGD, Gwilliam C, Hall CR, Haselschwardt SJ, Hertel SA, Hogan DP, Horn M, Huang DQ, Ignarra CM, Jacobsen RG, Jahangir O, Ji W, Kamdin K, Kazkaz K, Khaitan D, Knoche R, Korolkova EV, Kravitz S, Kudryavtsev VA, Lenardo BG, Lesko KT, Liao J, Lin J, Lindote A, Lopes MI, Manalaysay A, Mannino RL, Marangou N, Marzioni MF, McKinsey DN, Mei DM, Moongweluwan M, Morad JA, Murphy ASJ, Naylor A, Nehrkorn C, Nelson HN, Neves F, Oliver-Mallory KC, Palladino KJ, Pease EK, Riffard Q, Rischbieter GRC, Rhyne C, Rossiter P, Shaw S, Shutt TA, Silva C, Solmaz M, Solovov VN, Sorensen P, Sumner TJ, Szydagis M, Taylor DJ, Taylor WC, Tennyson BP, Terman PA, Tiedt DR, To WH, Tripathi M, Tvrznikova L, Utku U, Uvarov S, Velan V, Webb RC, White JT, Whitis TJ, Witherell MS, Wolfs FLH, Woodward D, Xu J, Yazdani K, and Zhang C
Abstract: The scattering of dark matter (DM) particles with sub-GeV masses off nuclei is difficult to detect using liquid xenon-based DM search instruments because the energy transfer during nuclear recoils is smaller than the typical detector threshold. However, the tree-level DM-nucleus scattering diagram can be accompanied by simultaneous emission of a bremsstrahlung photon or a so-called "Migdal" electron. These provide an electron recoil component to the experimental signature at higher energies than the corresponding nuclear recoil. The presence of this signature allows liquid xenon detectors to use both the scintillation and the ionization signals in the analysis where the nuclear recoil signal would not be otherwise visible. We report constraints on spin-independent DM-nucleon scattering for DM particles with masses of 0.4-5 GeV/c^{2} using 1.4×10^{4} kg day of search exposure from the 2013 data from the Large Underground Xenon (LUX) experiment for four different classes of mediators. This analysis extends the reach of liquid xenon-based DM search instruments to lower DM masses than has been achieved previously.
Published: 2019
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33. Targeting Brain Tumors with Nanomedicines: Overcoming Blood Brain Barrier Challenges.

Author: Khaitan D, Reddy PL, and Ningaraj N
Subjects: Animals, Antineoplastic Agents metabolism, Blood-Brain Barrier metabolism, Brain Neoplasms metabolism, Drug Delivery Systems methods, Humans, Nanomedicine methods, Antineoplastic Agents administration & dosage, Blood-Brain Barrier drug effects, Brain Neoplasms drug therapy, Drug Delivery Systems trends, Nanomedicine trends
Abstract: Background: This review elucidates ongoing research, which show improved delivery of anticancer drugs alone and/ or enclosed in carriers collectively called nanomedicines to cross the BBB/ BTB to kill tumor cells and impact patient survival. We highlighted various advances in understanding the mechanism of BTB function that has an impact on anticancer therapeutics delivery. We discussed latest breakthroughs in developing pharmaceutical strategies, including nanomedicines and delivering them across BTB for brain tumor management and treatment., Methods: We performed an extensive literature search and highlighted important studies on the regulation of BTB permeability with respect to nanotech-based nanomedicines for targeted treatment of brain tumors. We have reviewed research articles that describe the development of specialized molecules and nanospheres, which carry payload of anticancer agents to brain tumor cells across the BBB/ BTB and avoid drug efflux systems. We highlighted research on the identification and development of targeted anti-cancer drug delivery to brain tumors. In addition, we discussed multimeric molecular therapeutics and nanomedicines that were encapsulated in nanospheres for treatment and monitoring of brain tumors., Results: In this context, we quoted our research on large conductance calcium-activated potassium channels (BKCa) and ATP-dependent potassium channels (KATP) as portals of enhanced antineoplastic drugs delivery. We showed that several innovative drug delivery agents such as liposomes, polymeric nanoparticles, dendrimers and many such tools can be utilized to improve anticancer drugs and nanomedicines across the BTB to reach brain tumor cells., Conclusion: This review might interest both academic and drug company scientists involved in drug delivery to brain tumors. We further seek to present evidence that BTB modulators can be clinically developed as combination drug or/ and as stand-alone anticancer drugs. Eventually, it is expected that unrelenting effort from the scientific community in developing novel drug delivery methods should increase the survival rate of brain tumor patients, which is dismally low presently., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
Published: 2018
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34. First Searches for Axions and Axionlike Particles with the LUX Experiment.

Author: Akerib DS, Alsum S, Aquino C, Araújo HM, Bai X, Bailey AJ, Balajthy J, Beltrame P, Bernard EP, Bernstein A, Biesiadzinski TP, Boulton EM, Brás P, Byram D, Cahn SB, Carmona-Benitez MC, Chan C, Chiller AA, Chiller C, Currie A, Cutter JE, Davison TJR, Dobi A, Dobson JEY, Druszkiewicz E, Edwards BN, Faham CH, Fallon SR, Fiorucci S, Gaitskell RJ, Gehman VM, Ghag C, Gibson KR, Gilchriese MGD, Hall CR, Hanhardt M, Haselschwardt SJ, Hertel SA, Hogan DP, Horn M, Huang DQ, Ignarra CM, Jacobsen RG, Ji W, Kamdin K, Kazkaz K, Khaitan D, Knoche R, Larsen NA, Lee C, Lenardo BG, Lesko KT, Lindote A, Lopes MI, Manalaysay A, Mannino RL, Marzioni MF, McKinsey DN, Mei DM, Mock J, Moongweluwan M, Morad JA, Murphy ASJ, Nehrkorn C, Nelson HN, Neves F, O'Sullivan K, Oliver-Mallory KC, Palladino KJ, Pease EK, Reichhart L, Rhyne C, Shaw S, Shutt TA, Silva C, Solmaz M, Solovov VN, Sorensen P, Stephenson S, Sumner TJ, Szydagis M, Taylor DJ, Taylor WC, Tennyson BP, Terman PA, Tiedt DR, To WH, Tripathi M, Tvrznikova L, Uvarov S, Velan V, Verbus JR, Webb RC, White JT, Whitis TJ, Witherell MS, Wolfs FLH, Xu J, Yazdani K, Young SK, and Zhang C
Abstract: The first searches for axions and axionlike particles with the Large Underground Xenon experiment are presented. Under the assumption of an axioelectric interaction in xenon, the coupling constant between axions and electrons g_{Ae} is tested using data collected in 2013 with an exposure totaling 95 live days ×118 kg. A double-sided, profile likelihood ratio statistic test excludes g_{Ae} larger than 3.5×10^{-12} (90% C.L.) for solar axions. Assuming the Dine-Fischler-Srednicki-Zhitnitsky theoretical description, the upper limit in coupling corresponds to an upper limit on axion mass of 0.12 eV/c^{2}, while for the Kim-Shifman-Vainshtein-Zhakharov description masses above 36.6 eV/c^{2} are excluded. For galactic axionlike particles, values of g_{Ae} larger than 4.2×10^{-13} are excluded for particle masses in the range 1-16 keV/c^{2}. These are the most stringent constraints to date for these interactions.
Published: 2017
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35. Limits on Spin-Dependent WIMP-Nucleon Cross Section Obtained from the Complete LUX Exposure.

Author: Akerib DS, Alsum S, Araújo HM, Bai X, Bailey AJ, Balajthy J, Beltrame P, Bernard EP, Bernstein A, Biesiadzinski TP, Boulton EM, Brás P, Byram D, Cahn SB, Carmona-Benitez MC, Chan C, Chiller AA, Chiller C, Currie A, Cutter JE, Davison TJR, Dobi A, Dobson JEY, Druszkiewicz E, Edwards BN, Faham CH, Fallon SR, Fiorucci S, Gaitskell RJ, Gehman VM, Ghag C, Gilchriese MGD, Hall CR, Hanhardt M, Haselschwardt SJ, Hertel SA, Hogan DP, Horn M, Huang DQ, Ignarra CM, Jacobsen RG, Ji W, Kamdin K, Kazkaz K, Khaitan D, Knoche R, Larsen NA, Lee C, Lenardo BG, Lesko KT, Lindote A, Lopes MI, Manalaysay A, Mannino RL, Marzioni MF, McKinsey DN, Mei DM, Mock J, Moongweluwan M, Morad JA, Murphy ASJ, Nehrkorn C, Nelson HN, Neves F, O'Sullivan K, Oliver-Mallory KC, Palladino KJ, Pease EK, Reichhart L, Rhyne C, Shaw S, Shutt TA, Silva C, Solmaz M, Solovov VN, Sorensen P, Stephenson S, Sumner TJ, Szydagis M, Taylor DJ, Taylor WC, Tennyson BP, Terman PA, Tiedt DR, To WH, Tripathi M, Tvrznikova L, Uvarov S, Velan V, Verbus JR, Webb RC, White JT, Whitis TJ, Witherell MS, Wolfs FLH, Xu J, Yazdani K, Young SK, and Zhang C
Abstract: We present experimental constraints on the spin-dependent WIMP-nucleon elastic cross sections from the total 129.5 kg yr exposure acquired by the Large Underground Xenon experiment (LUX), operating at the Sanford Underground Research Facility in Lead, South Dakota (USA). A profile likelihood ratio analysis allows 90% C.L. upper limits to be set on the WIMP-neutron (WIMP-proton) cross section of σ_{n}=1.6×10^{-41} cm^{2} (σ_{p}=5×10^{-40} cm^{2}) at 35 GeV c^{-2}, almost a sixfold improvement over the previous LUX spin-dependent results. The spin-dependent WIMP-neutron limit is the most sensitive constraint to date.
Published: 2017
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36. Results from a Search for Dark Matter in the Complete LUX Exposure.

Author: Akerib DS, Alsum S, Araújo HM, Bai X, Bailey AJ, Balajthy J, Beltrame P, Bernard EP, Bernstein A, Biesiadzinski TP, Boulton EM, Bramante R, Brás P, Byram D, Cahn SB, Carmona-Benitez MC, Chan C, Chiller AA, Chiller C, Currie A, Cutter JE, Davison TJ, Dobi A, Dobson JE, Druszkiewicz E, Edwards BN, Faham CH, Fiorucci S, Gaitskell RJ, Gehman VM, Ghag C, Gibson KR, Gilchriese MG, Hall CR, Hanhardt M, Haselschwardt SJ, Hertel SA, Hogan DP, Horn M, Huang DQ, Ignarra CM, Ihm M, Jacobsen RG, Ji W, Kamdin K, Kazkaz K, Khaitan D, Knoche R, Larsen NA, Lee C, Lenardo BG, Lesko KT, Lindote A, Lopes MI, Manalaysay A, Mannino RL, Marzioni MF, McKinsey DN, Mei DM, Mock J, Moongweluwan M, Morad JA, Murphy AS, Nehrkorn C, Nelson HN, Neves F, O'Sullivan K, Oliver-Mallory KC, Palladino KJ, Pease EK, Phelps P, Reichhart L, Rhyne C, Shaw S, Shutt TA, Silva C, Solmaz M, Solovov VN, Sorensen P, Stephenson S, Sumner TJ, Szydagis M, Taylor DJ, Taylor WC, Tennyson BP, Terman PA, Tiedt DR, To WH, Tripathi M, Tvrznikova L, Uvarov S, Verbus JR, Webb RC, White JT, Whitis TJ, Witherell MS, Wolfs FL, Xu J, Yazdani K, Young SK, and Zhang C
Abstract: We report constraints on spin-independent weakly interacting massive particle (WIMP)-nucleon scattering using a 3.35×10^{4} kg day exposure of the Large Underground Xenon (LUX) experiment. A dual-phase xenon time projection chamber with 250 kg of active mass is operated at the Sanford Underground Research Facility under Lead, South Dakota (USA). With roughly fourfold improvement in sensitivity for high WIMP masses relative to our previous results, this search yields no evidence of WIMP nuclear recoils. At a WIMP mass of 50 GeV c^{-2}, WIMP-nucleon spin-independent cross sections above 2.2×10^{-46} cm^{2} are excluded at the 90% confidence level. When combined with the previously reported LUX exposure, this exclusion strengthens to 1.1×10^{-46} cm^{2} at 50 GeV c^{-2}.
Published: 2017
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37. Results on the Spin-Dependent Scattering of Weakly Interacting Massive Particles on Nucleons from the Run 3 Data of the LUX Experiment.

Author: Akerib DS, Araújo HM, Bai X, Bailey AJ, Balajthy J, Beltrame P, Bernard EP, Bernstein A, Biesiadzinski TP, Boulton EM, Bradley A, Bramante R, Cahn SB, Carmona-Benitez MC, Chan C, Chapman JJ, Chiller AA, Chiller C, Currie A, Cutter JE, Davison TJ, de Viveiros L, Dobi A, Dobson JE, Druszkiewicz E, Edwards BN, Faham CH, Fiorucci S, Gaitskell RJ, Gehman VM, Ghag C, Gibson KR, Gilchriese MG, Hall CR, Hanhardt M, Haselschwardt SJ, Hertel SA, Hogan DP, Horn M, Huang DQ, Ignarra CM, Ihm M, Jacobsen RG, Ji W, Kazkaz K, Khaitan D, Knoche R, Larsen NA, Lee C, Lenardo BG, Lesko KT, Lindote A, Lopes MI, Malling DC, Manalaysay A, Mannino RL, Marzioni MF, McKinsey DN, Mei DM, Mock J, Moongweluwan M, Morad JA, Murphy AS, Nehrkorn C, Nelson HN, Neves F, O'Sullivan K, Oliver-Mallory KC, Ott RA, Palladino KJ, Pangilinan M, Pease EK, Phelps P, Reichhart L, Rhyne C, Shaw S, Shutt TA, Silva C, Solovov VN, Sorensen P, Stephenson S, Sumner TJ, Szydagis M, Taylor DJ, Taylor W, Tennyson BP, Terman PA, Tiedt DR, To WH, Tripathi M, Tvrznikova L, Uvarov S, Verbus JR, Webb RC, White JT, Whitis TJ, Witherell MS, Wolfs FL, Yazdani K, Young SK, and Zhang C
Abstract: We present experimental constraints on the spin-dependent WIMP (weakly interacting massive particle)-nucleon elastic cross sections from LUX data acquired in 2013. LUX is a dual-phase xenon time projection chamber operating at the Sanford Underground Research Facility (Lead, South Dakota), which is designed to observe the recoil signature of galactic WIMPs scattering from xenon nuclei. A profile likelihood ratio analysis of 1.4×10^{4} kg day of fiducial exposure allows 90% C.L. upper limits to be set on the WIMP-neutron (WIMP-proton) cross section of σ_{n}=9.4×10^{-41} cm^{2} (σ_{p}=2.9×10^{-39} cm^{2}) at 33 GeV/c^{2}. The spin-dependent WIMP-neutron limit is the most sensitive constraint to date.
Published: 2016
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38. Improved Limits on Scattering of Weakly Interacting Massive Particles from Reanalysis of 2013 LUX Data.

Author: Akerib DS, Araújo HM, Bai X, Bailey AJ, Balajthy J, Beltrame P, Bernard EP, Bernstein A, Biesiadzinski TP, Boulton EM, Bradley A, Bramante R, Cahn SB, Carmona-Benitez MC, Chan C, Chapman JJ, Chiller AA, Chiller C, Currie A, Cutter JE, Davison TJ, de Viveiros L, Dobi A, Dobson JE, Druszkiewicz E, Edwards BN, Faham CH, Fiorucci S, Gaitskell RJ, Gehman VM, Ghag C, Gibson KR, Gilchriese MG, Hall CR, Hanhardt M, Haselschwardt SJ, Hertel SA, Hogan DP, Horn M, Huang DQ, Ignarra CM, Ihm M, Jacobsen RG, Ji W, Kazkaz K, Khaitan D, Knoche R, Larsen NA, Lee C, Lenardo BG, Lesko KT, Lindote A, Lopes MI, Malling DC, Manalaysay A, Mannino RL, Marzioni MF, McKinsey DN, Mei DM, Mock J, Moongweluwan M, Morad JA, Murphy AS, Nehrkorn C, Nelson HN, Neves F, O'Sullivan K, Oliver-Mallory KC, Ott RA, Palladino KJ, Pangilinan M, Pease EK, Phelps P, Reichhart L, Rhyne C, Shaw S, Shutt TA, Silva C, Solovov VN, Sorensen P, Stephenson S, Sumner TJ, Szydagis M, Taylor DJ, Taylor W, Tennyson BP, Terman PA, Tiedt DR, To WH, Tripathi M, Tvrznikova L, Uvarov S, Verbus JR, Webb RC, White JT, Whitis TJ, Witherell MS, Wolfs FL, Yazdani K, Young SK, and Zhang C
Abstract: We present constraints on weakly interacting massive particles (WIMP)-nucleus scattering from the 2013 data of the Large Underground Xenon dark matter experiment, including 1.4×10^{4} kg day of search exposure. This new analysis incorporates several advances: single-photon calibration at the scintillation wavelength, improved event-reconstruction algorithms, a revised background model including events originating on the detector walls in an enlarged fiducial volume, and new calibrations from decays of an injected tritium β source and from kinematically constrained nuclear recoils down to 1.1 keV. Sensitivity, especially to low-mass WIMPs, is enhanced compared to our previous results which modeled the signal only above a 3 keV minimum energy. Under standard dark matter halo assumptions and in the mass range above 4 GeV c^{-2}, these new results give the most stringent direct limits on the spin-independent WIMP-nucleon cross section. The 90% C.L. upper limit has a minimum of 0.6 zb at 33 GeV c^{-2} WIMP mass.
Published: 2016
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39. Targeting potassium channels for increasing delivery of imaging agents and therapeutics to brain tumors.

Author: Khaitan D and Ningaraj NS
Abstract: Every year in the US, 20,000 new primary and nearly 200,000 metastatic brain tumor cases are reported. The cerebral microvessels/capillaries that form the blood-brain barrier not only protect the brain from toxic agents in the blood but also pose a significant hindrance to the delivery of small and large therapeutic molecules. Different strategies have been employed to circumvent the physiological barrier posed by blood-brain tumor barrier (BTB). Studies in our laboratory have identified significant differences in the expression levels of certain genes and proteins between normal and brain tumor capillary endothelial cells (ECs). In this study, we validated the non-invasive and clinically relevant dynamic contrast enhancing-magnetic resonance imaging (DCE-MRI) method with invasive, clinically irrelevant but highly accurate quantitative autoradiography method using rat glioma model. We also showed that DCE-MRI metric of tissue vessel perfusion-permeability is sensitive to changes in blood vessel permeability following administration of calcium-activated potassium (BKCa) channel activator NS-1619. Our results show that human gliomas and brain tumor ECs that overexpress BKCa channels can be targeted for increased BTB permeability for MRI enhancing agents to brain tumors. We conclude that monitoring the outcome of increased MRI enhancing agents' delivery to microsatellites and leading tumor edges in glioma patients would lead to beneficial clinical outcome.
Published: 2013
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40. The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis and invasion.

Author: Khaitan D, Dinger ME, Mazar J, Crawford J, Smith MA, Mattick JS, and Perera RJ
Subjects: Apoptosis genetics, Base Sequence, Cell Line, Tumor, Cell Movement genetics, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, Humans, Intracellular Signaling Peptides and Proteins metabolism, Melanoma pathology, Molecular Sequence Data, Neoplasm Invasiveness, Nerve Tissue Proteins biosynthesis, Nerve Tissue Proteins metabolism, RNA, Untranslated metabolism, Transfection, Up-Regulation, Intracellular Signaling Peptides and Proteins genetics, Melanoma genetics, Nerve Tissue Proteins genetics, RNA, Untranslated genetics
Abstract: The identification of cancer-associated long noncoding RNAs (lncRNAs) and the investigation of their molecular and biological functions are important to understand the molecular biology of cancer and its progression. Although the functions of lncRNAs and the mechanisms regulating their expression are largely unknown, recent studies are beginning to unravel their importance in human health and disease. Here, we report that a number of lncRNAs are differentially expressed in melanoma cell lines in comparison to melanocytes and keratinocyte controls. One of these lncRNAs, SPRY4-IT1 (GenBank accession ID AK024556), is derived from an intron of the SPRY4 gene and is predicted to contain several long hairpins in its secondary structure. RNA-FISH analysis showed that SPRY4-IT1 is predominantly localized in the cytoplasm of melanoma cells, and SPRY4-IT1 RNAi knockdown results in defects in cell growth, differentiation, and higher rates of apoptosis in melanoma cell lines. Differential expression of both SPRY4 and SPRY4-IT1 was also detected in vivo, in 30 distinct patient samples, classified as primary in situ, regional metastatic, distant metastatic, and nodal metastatic melanoma. The elevated expression of SPRY4-IT1 in melanoma cells compared to melanocytes, its accumulation in cell cytoplasm, and effects on cell dynamics, including increased rate of wound closure on SPRY4-IT1 overexpression, suggest that the higher expression of SPRY4-IT1 may have an important role in the molecular etiology of human melanoma.
Published: 2011
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41. 7, 8-diacetoxy-4-methylcoumarin induced cell death in human tumor cells is influenced by calreticulin.

Author: Verma A, Bhatt AN, Farooque A, Khanna S, Khaitan D, Arya MB, Arya A, Dhawan A, Raj HG, Saluja D, Prasad AK, Parmar VS, and Dwarakanath BS
Subjects: Acetylation drug effects, Calreticulin deficiency, Calreticulin genetics, Cell Death drug effects, Cell Line, Tumor, Cell Proliferation drug effects, Drug Resistance, Neoplasm drug effects, Gene Expression Regulation, Neoplastic drug effects, Gene Knockdown Techniques, Humans, NF-kappa B metabolism, RNA, Small Interfering genetics, Reactive Oxygen Species metabolism, Calreticulin metabolism, Coumarins pharmacology
Abstract: Calreticulin (CRT), an endoplasmic reticulum resident protein demonstrates transacetylase activity in presence of 7, 8 diacetoxy-4-methyl coumarin (DAMC) in vitro. To investigate the possible role of CRT and DAMC mediated protein acetylation in cells, we investigated the effects of DAMC in tumor cells with different levels of CRT. DAMC was more toxic (clonogenicity, metabolic viability and proliferation) to human glioma cells (BMG-1) expressing low endogenous CRT level as compared to head and neck carcinoma cells (KB) with a high CRT level. The cytotoxicity was accompanied by loss of mitochondrial membrane potential in both the cells, which correlated with corresponding changes in the levels of pro-apoptotic (Bax) and anti-apoptotic (NFkB) regulators. Manipulation of CRT protein level in KB cells by application of small RNA interference enhanced the sensitivity by four folds while over expression of CRT in BMG-1 cells reduced their sensitivity to DAMC by ~20% strongly suggesting the influence of CRT on DAMC induced cytotoxicity. The partial rescue of CROE cells from DAMC induced toxicity was accompanied by changes in NFkB levels and over all protein acetylation status, besides increase in the NADPH-cytochrome c reductase activity related to its well known antioxidant property. Since CRT is over-expressed in cancer cells, which are generally resistant to radio- and chemotherapy; targeting CRT transacetylase system, may be an attractive approach for increasing the efficacy of anticancer therapies., (Copyright © 2010. Published by Elsevier Masson SAS.)
Published: 2011
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42. Epigenetic regulation of microRNA genes and the role of miR-34b in cell invasion and motility in human melanoma.

Author: Mazar J, Khaitan D, DeBlasio D, Zhong C, Govindarajan SS, Kopanathi S, Zhang S, Ray A, and Perera RJ
Subjects: Biomarkers, Tumor genetics, Biomarkers, Tumor metabolism, Blotting, Northern, Cell Adhesion, Cell Line, Tumor, CpG Islands, DNA Methylation, Gene Expression Profiling, Gene Silencing, Humans, Neoplasm Invasiveness, Oligonucleotide Array Sequence Analysis, Promoter Regions, Genetic genetics, RNA, Messenger genetics, Real-Time Polymerase Chain Reaction, Skin Neoplasms genetics, Skin Neoplasms metabolism, Skin Neoplasms pathology, Wound Healing, Cell Movement, Epigenomics, Gene Expression Regulation, Neoplastic, Melanoma genetics, Melanoma secondary, MicroRNAs genetics
Abstract: Invasive melanoma is the most lethal form of skin cancer. The treatment of melanoma-derived cell lines with 5-aza-2'-deoxycytidine (5-Aza-dC) markedly increases the expression of several miRNAs, suggesting that the miRNA-encoding genes might be epigenetically regulated, either directly or indirectly, by DNA methylation. We have identified a group of epigenetically regulated miRNA genes in melanoma cells, and have confirmed that the upstream CpG island sequences of several such miRNA genes are hypermethylated in cell lines derived from different stages of melanoma, but not in melanocytes and keratinocytes. We used direct DNA bisulfite and immunoprecipitated DNA (Methyl-DIP) to identify changes in CpG island methylation in distinct melanoma patient samples classified as primary in situ, regional metastatic, and distant metastatic. Two melanoma cell lines (WM1552C and A375 derived from stage 3 and stage 4 human melanoma, respectively) were engineered to ectopically express one of the epigenetically modified miRNA: miR-34b. Expression of miR-34b reduced cell invasion and motility rates of both WM1552C and A375, suggesting that the enhanced cell invasiveness and motility observed in metastatic melanoma cells may be related to their reduced expression of miR-34b. Total RNA isolated from control or miR-34b-expressing WM1552C cells was subjected to deep sequencing to identify gene networks around miR-34b. We identified network modules that are potentially regulated by miR-34b, and which suggest a mechanism for the role of miR-34b in regulating normal cell motility and cytokinesis.
Published: 2011
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43. The regulation of miRNA-211 expression and its role in melanoma cell invasiveness.

Author: Mazar J, DeYoung K, Khaitan D, Meister E, Almodovar A, Goydos J, Ray A, and Perera RJ
Subjects: 3' Untranslated Regions genetics, Binding Sites genetics, Blotting, Western, Cell Line, Cell Line, Tumor, Cell Proliferation, Cells, Cultured, Humans, Introns genetics, Large-Conductance Calcium-Activated Potassium Channel alpha Subunits metabolism, Melanoma genetics, Melanoma pathology, MicroRNAs metabolism, Mutation, Neoplasm Invasiveness, Oligonucleotide Array Sequence Analysis, RNA Interference, Reverse Transcriptase Polymerase Chain Reaction, TRPM Cation Channels genetics, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Large-Conductance Calcium-Activated Potassium Channel alpha Subunits genetics, MicroRNAs genetics
Abstract: The immediate molecular mechanisms behind invasive melanoma are poorly understood. Recent studies implicate microRNAs (miRNAs) as important agents in melanoma and other cancers. To investigate the role of miRNAs in melanoma, we subjected human melanoma cell lines to miRNA expression profiling, and report a range of variations in several miRNAs. Specifically, compared with expression levels in melanocytes, levels of miR-211 were consistently reduced in all eight non-pigmented melanoma cell lines we examined; they were also reduced in 21 out of 30 distinct melanoma samples from patients, classified as primary in situ, regional metastatic, distant metastatic, and nodal metastatic. The levels of several predicted target mRNAs of miR-211 were reduced in melanoma cell lines that ectopically expressed miR-211. In vivo target cleavage assays confirmed one such target mRNA encoded by KCNMA1. Mutating the miR-211 binding site seed sequences at the KCNMA1 3'-UTR abolished target cleavage. KCNMA1 mRNA and protein expression levels varied inversely with miR-211 levels. Two different melanoma cell lines ectopically expressing miR-211 exhibited significant growth inhibition and reduced invasiveness compared with the respective parental melanoma cell lines. An shRNA against KCNMA1 mRNA also demonstrated similar effects on melanoma cells. miR-211 is encoded within the sixth intron of TRPM1, a candidate suppressor of melanoma metastasis. The transcription factor MITF, important for melanocyte development and function, is needed for high TRPM1 expression. MITF is also needed for miR-211 expression, suggesting that the tumor-suppressor activities of MITF and/or TRPM1 may at least partially be due to miR-211's negative post transcriptional effects on the KCNMA1 transcript. Given previous reports of high KCNMA1 levels in metastasizing melanoma, prostate cancer and glioma, our findings that miR-211 is a direct posttranscriptional regulator of KCNMA1 expression as well as the dependence of this miRNA's expression on MITF activity, establishes miR-211 as an important regulatory agent in human melanoma.
Published: 2010
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44. Modulation of KCa channels increases anticancer drug delivery to brain tumors and prolongs survival in xenograft model.

Author: Ningaraj NS, Sankpal UT, Khaitan D, Meister EA, and Vats TS
Subjects: Animals, Antibodies, Monoclonal administration & dosage, Antibodies, Monoclonal pharmacokinetics, Antibodies, Monoclonal, Humanized, Antineoplastic Agents pharmacokinetics, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Apoptosis drug effects, Benzimidazoles administration & dosage, Blood-Brain Barrier drug effects, Blood-Brain Barrier metabolism, Brain drug effects, Brain metabolism, Brain pathology, Brain Neoplasms metabolism, Brain Neoplasms pathology, Cell Line, Tumor, Dacarbazine administration & dosage, Dacarbazine analogs & derivatives, Dacarbazine pharmacokinetics, Drug Delivery Systems, Female, Flow Cytometry, Glioma drug therapy, Glioma metabolism, Glioma pathology, Humans, Immunoblotting, Large-Conductance Calcium-Activated Potassium Channel alpha Subunits genetics, Large-Conductance Calcium-Activated Potassium Channel alpha Subunits metabolism, Mice, Mice, Nude, Rats, Rats, Nude, Reverse Transcriptase Polymerase Chain Reaction, Survival Analysis, Temozolomide, Trastuzumab, Antineoplastic Agents administration & dosage, Brain Neoplasms drug therapy, Large-Conductance Calcium-Activated Potassium Channel alpha Subunits agonists, Xenograft Model Antitumor Assays methods
Abstract: Most anticancer drugs fail to impact patient survival since they fail to cross the blood-brain tumor barrier (BTB) at therapeutic levels. For example, Temozolomide (TMZ) exhibits some antitumor activity against brain tumors, so does Trastuzumab (Herceptin, Her-2 inhibitor), which might be effective against Her2 neu overexpressing gliomas. Nevertheless, intact BTB and active efflux system may prevent their entry to brain tumors. Previously we have shown that potassium channel agonists increased carboplatin and Her-2 neu antibody delivery in animal glioma models. Here, we studied whether potassium channel agonist increase TMZ and Herceptin delivery across the BTB to elicit antitumor activity and increase survival in nude mice with human glial tumor. The K(Ca) channel activity and expression was also evaluated in human glioma tissues. We administered NS-1619, calcium-dependent potassium (K(Ca)) channel agonist, with [(14)C]-TMZ, and quantified TMZ delivery. The results clearly demonstrate that when given systemically both TMZ and Herceptin do not cross the BTB in significant amounts, however, NS-1619 co-infusion with [(14)C]-TMZ and Herceptin resulted in enhanced drug delivery to brain-tumor cells. The combination treatment of TMZ and Herceptin also showed improved antitumor effect which was more prominent than that of either treatment alone in increasing the survival in mice with brain tumor, when co-infused with K(Ca) channel agonists. In conclusion, K(Ca) channel agonists may benefit brain tumor patients by increasing anti-neoplastic agent's delivery to brain tumors. A clinical outcome of this research is the discovery of a novel drug delivery system that circumvents the BBB/BTB to benefit brain tumor patients.
Published: 2009
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45. Short-term exposure of multicellular tumor spheroids of a human glioma cell line to the glycolytic inhibitor 2-deoxy-D-glucose is more toxic than continuous exposure.

Author: Khaitan D, Chandna S, and Dwarakanath SB
Subjects: Apoptosis drug effects, Cell Line, Tumor, Cell Separation, Cell Survival drug effects, Drug Resistance, Neoplasm drug effects, Flow Cytometry, Glycolysis drug effects, Humans, Oxidative Stress drug effects, Spheroids, Cellular, Time, Antineoplastic Agents administration & dosage, Brain Neoplasms metabolism, Cell Proliferation drug effects, Deoxyglucose administration & dosage, Glioma metabolism
Abstract: The glycolytic inhibitor 2-deoxy-D-glucose (2-DG) has been used as a therapeutic agent and as an adjuvant in cancer therapy with either weekly fractions of the treatment or daily administration. While the weekly fraction has often been found to be nontoxic and effective, other treatment regimes are tolerated to a relatively lesser extent. It was therefore, considered worthwhile to investigate the efficacy of short- and long-term exposure of tumor cells to 2-DG under the controlled conditions. Seven-day-old MTS were exposed to 2-DG (5 mM, equimolar to glucose concentration in media) for different time intervals (30 min to 24 h) trypsinized and plated for clonogenicity. Alternatively, spheroids were grown either continuously in the presence of 2-DG or were treated with 2-DG for 2 h (short-term exposure) and grown in 2-DG-free media for 21 days and assessed for spheroid growth, cell viability, apoptosis, cytogenetic damage, mitochondrial status, and oxidative stress. Exposure of spheroids to 2-DG for 2-4 h induced 30% cell death (SF 0.70) while, a 24-h exposure resulted in only a marginal decrease in clonogenicity (SF 0.95). Furthermore, the spheroids disintegrated completely by 28 days in the case of 2-h exposure to 2-DG, while spheroids grown continuously in the presence of 2-DG repopulated. The cytotoxicity following short-term exposure of MTS to 2-DG was primarily due to the induction of apoptosis revealed by morphological features as well as flow cytometric analysis of the DNA content. Interestingly however, cytogenetic damage (micronuclei induction) was observed in spheroids that were continuously exposed to 2-DG. Short-term exposure to 2-DG resulted in a significant increase in ROS levels and a reduction in the levels of unoxidized cardiolipin as measured by NAO suggesting the involvement of mitochondria leakiness leading to oxidative stress which, could be responsible for apoptotic cell death observed under these conditions. However, continuous exposure to 2-DG resulted in a moderate level of oxidative stress leading to the genomic instability. Preliminary studies also show that spheroids exposed continuously to 2-DG result in the development of resistance to certain chemotherapeutic drugs which could be correlated with elevated levels of mdr1. The present results suggest that a persistent down-regulation of glycolysis (as seen here with continuous exposure to 2-DG) could activate prosurvival responses besides inducing moderate levels of oxidative stress resulting in the development of resistance against therapeutic agents.
Published: 2009
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46. Role of KCNMA1 gene in breast cancer invasion and metastasis to brain.

Author: Khaitan D, Sankpal UT, Weksler B, Meister EA, Romero IA, Couraud PO, and Ningaraj NS
Subjects: Brain Neoplasms genetics, Brain Neoplasms metabolism, Breast Neoplasms metabolism, Cell Membrane metabolism, Cell Movement, Exons, Gene Expression Profiling, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, Peptides pharmacology, Prognosis, RNA, Small Interfering metabolism, Brain Neoplasms secondary, Breast Neoplasms genetics, Breast Neoplasms pathology, Gene Expression Regulation, Neoplastic, Large-Conductance Calcium-Activated Potassium Channel alpha Subunits genetics, Large-Conductance Calcium-Activated Potassium Channel alpha Subunits physiology
Abstract: Background: The prognosis for patients with breast tumor metastases to brain is extremely poor. Identification of prognostic molecular markers of the metastatic process is critical for designing therapeutic modalities for reducing the occurrence of metastasis. Although ubiquitously present in most human organs, large-conductance calcium- and voltage-activated potassium channel (BKCa) channels are significantly upregulated in breast cancer cells. In this study we investigated the role of KCNMA1 gene that encodes for the pore-forming alpha-subunit of BKCa channels in breast cancer metastasis and invasion., Methods: We performed Global exon array to study the expression of KCNMA1 in metastatic breast cancer to brain, compared its expression in primary breast cancer and breast cancers metastatic to other organs, and validated the findings by RT-PCR. Immunohistochemistry was performed to study the expression and localization of BKCa channel protein in primary and metastatic breast cancer tissues and breast cancer cell lines. We performed matrigel invasion, transendothelial migration and membrane potential assays in established lines of normal breast cells (MCF-10A), non-metastatic breast cancer (MCF-7), non-brain metastatic breast cancer cells (MDA-MB-231), and brain-specific metastatic breast cancer cells (MDA-MB-361) to study whether BKCa channel inhibition attenuates breast tumor invasion and metastasis using KCNMA1 knockdown with siRNA and biochemical inhibition with Iberiotoxin (IBTX)., Results: The Global exon array and RT-PCR showed higher KCNMA1 expression in metastatic breast cancer in brain compared to metastatic breast cancers in other organs. Our results clearly show that metastatic breast cancer cells exhibit increased BKCa channel activity, leading to greater invasiveness and transendothelial migration, both of which could be attenuated by blocking KCNMA1., Conclusion: Determining the relative abundance of BKCa channel expression in breast cancer metastatic to brain and the mechanism of its action in brain metastasis will provide a unique opportunity to identify and differentiate between low grade breast tumors that are at high risk for metastasis from those at low risk for metastasis. This distinction would in turn allow for the appropriate and efficient application of effective treatments while sparing patients with low risk for metastasis from the toxic side effects of chemotherapy.
Published: 2009
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47. Stress response of a p53 homologue in the radioresistant Sf9 insect cells.

Author: Suman S, Khaitan D, Pati U, Seth RK, and Chandna S
Subjects: Active Transport, Cell Nucleus, Amino Acid Sequence, Animals, Ataxia Telangiectasia Mutated Proteins, Caffeine pharmacology, Cell Cycle Proteins antagonists & inhibitors, Cell Cycle Proteins metabolism, Cell Line, Cell Line, Tumor, Cell Nucleus metabolism, Cytoplasm metabolism, DNA Damage, DNA-Binding Proteins antagonists & inhibitors, DNA-Binding Proteins metabolism, Etoposide pharmacology, Gamma Rays, Humans, Insect Proteins genetics, Molecular Sequence Data, Protein Serine-Threonine Kinases antagonists & inhibitors, Protein Serine-Threonine Kinases metabolism, Sequence Homology, Amino Acid, Spodoptera cytology, Tumor Suppressor Protein p53 genetics, Tumor Suppressor Proteins antagonists & inhibitors, Tumor Suppressor Proteins metabolism, Insect Proteins physiology, Radiation Tolerance, Tumor Suppressor Protein p53 physiology
Abstract: Purpose: To investigate homology and stress response of p53 (a 53 kDa tumor suppressor protein) orthologue in Sf9 Lepidopteran insect cell line that exhibits very high radioresistance., Materials and Methods: Western immunoblotting, immunoprecipitation, degenerate RT-PCR (reverse transcription-polymerase chain reaction), electrophoretic gel mobility shift assay, flow cytometry and immuno-fluorescence microscopy were used for characterizing structural and functional features of Sfp53 (Spodoptera frugiperda p53) in gamma-irradiated or etoposide-treated Sf9 insect and BMG-1 (brain malignant glioma) human cells. Cells were pre-treated with caffeine for inhibiting ATM/ATR (ataxia-telangiectasia mutated protein/ATM and Rad-3-related protein) activation, wherever required., Results: A 47-49 kDa protein band was observed with antibodies against three different epitopes, demonstrating conservation of respective domains in Sfp53. Immunoprecipitation also yielded similar-sized protein. Degenerate RT-PCR resulted in product of same size in both cell lines. Similar gel mobility shift of p53-binding oligonucleotide with BMG-1 and Sf9 cell lysates indicated analogous transcriptional activity of Sfp53. Constitutive Sfp53 level was higher than hp53 (human p53) and showed primarily cytoplasmic localization. Radiation-induced accumulation was considerably less in Sf9 even as an analogous ATM/ATR-dependent nuclear translocation was observed following gamma-irradiation and etoposide., Conclusions: A smaller-sized Sfp53 orthologue shows highly conserved native structure with DNA-binding, N-terminus and C-terminus domains, and has analogous p53 transcriptional activity. While its nuclear translocation and ATM/ATR dependence were similar to hp53, the cytoplasmic localization and subdued accumulation following gamma-irradiation indicate functional differences from human cells.
Published: 2009
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48. Endogenous and induced oxidative stress in multi-cellular tumour spheroids: implications for improving tumour therapy.

Author: Khaitan D and Dwarakanath BS
Subjects: ATP Binding Cassette Transporter, Subfamily B, Member 1 metabolism, Antineoplastic Agents therapeutic use, Cell Death, Humans, Hypoxia-Inducible Factor 1, alpha Subunit metabolism, Neoplasms pathology, Neoplasms physiopathology, Neovascularization, Pathologic, Oxidation-Reduction, Reactive Oxygen Species metabolism, Spheroids, Cellular drug effects, Tumor Cells, Cultured, Neoplasms therapy, Oxidative Stress drug effects, Spheroids, Cellular physiology
Abstract: The endogenous oxidative stress in tumours is determined by the status of mitochondrial, metabolic, oxygen (hypoxia) and inherent enzymatic as well as non-enzymatic antioxidant defense systems, which influence tumour growth and respond to anticancer therapeutics. Induced oxidative stress is one of the important determinants of the outcome of treatment with certain chemotherapeutic drugs and ionizing radiation. The mild to moderate levels of reactive oxygen species (ROS) have often been found to trigger prosurvival responses, thereby contributing to the resistance against therapy. The higher levels of ROS stimulate multiple death pathways viz. typical and atypical apoptosis, necrosis etc, thereby enhancing the therapeutic efficiency. Therefore, approaches employing therapeutic agents that generate ROS efficiently in the tumour cells and enhance the antioxidant defense system in the normal cells could significantly enhance the therapeutic gain. Multi-cellular tumour spheroids (MCTS) offer an excellent in vitro system that mimics endogenous oxidative stress often observed in tumours, arising due to a number of factors (gradients of oxygen and nutrients, altered intercellular interaction and tumour necrosis factor), besides antioxidant defense systems similar to tumours in vivo. More importantly, MCTS resemble tumours in vivo with reference to the induced oxidative stress related responses, particularly following combinations of certain chemotherapeutic drugs and metabolic inhibitors and differs significantly from the responses in monolayer cultures. Therefore, MCTS appear to be excellent in vitro models, ideally suited for developing novel therapies that are based on the generation of oxidative stress in tumours. The present review provides a modest account on the utility of MCTS in understanding the role of oxidative stress in treatment-induced responses of tumours for designing therapies and therapeutics.
Published: 2009

49. Activation of KATP channels increases anticancer drug delivery to brain tumors and survival.

Author: Ningaraj NS, Sankpal UT, Khaitan D, Meister EA, and Vats T
Subjects: Animals, Antibodies, Monoclonal administration & dosage, Antibodies, Monoclonal metabolism, Antibodies, Monoclonal pharmacology, Antibodies, Monoclonal, Humanized, Antineoplastic Agents pharmacology, Antineoplastic Combined Chemotherapy Protocols, Apoptosis drug effects, Blood-Brain Barrier metabolism, Brain Neoplasms genetics, Brain Neoplasms pathology, Carbon Radioisotopes chemistry, Cell Line, Tumor, Dacarbazine administration & dosage, Dacarbazine analogs & derivatives, Dacarbazine chemistry, Dacarbazine metabolism, Dacarbazine pharmacology, Gene Expression Regulation, Neoplastic, Glioblastoma drug therapy, Glioblastoma genetics, Glioblastoma pathology, Humans, KATP Channels genetics, KATP Channels metabolism, Mice, Minoxidil analogs & derivatives, Minoxidil pharmacology, Survival Rate, Temozolomide, Transplantation, Heterologous, Trastuzumab, Antineoplastic Agents administration & dosage, Antineoplastic Agents pharmacokinetics, Brain Neoplasms drug therapy, Brain Neoplasms metabolism, Drug Delivery Systems methods, Glioblastoma metabolism, KATP Channels agonists
Abstract: Several anticancer drugs are ineffective against brain tumor and do not impact patient survival because they fail to cross the blood-brain tumor barrier (BTB) effective levels. One such agent temozolomide is commonly used in brain tumor patients, which works better when combined with radiation or other anticancer agents. Likewise, trastuzumab (Herceptin, Her-2 inhibitor), which might be effective against Her2/neu over expressing gliomas may work well when combined with temozolomide. Nonetheless, both drugs do not cross the BTB to significantly impact patient survival. Beforehand we showed that potassium channel agonists when intracarotidly administered increased carboplatin and Her-2 antibody delivery in animal glioma models by triggering formation of brain vascular endothelial transcytotic vesicles. In this study, we investigated whether, intravenously administered, ATP-sensitive potassium channel (K(ATP)) activator (minoxidil sulfate; MS) increases temozolomide and Herceptin delivery to brain tumors to induce anti-tumor activity and increase survival in nude mice with Glioblastoma multiforme (GBM) cells. The results clearly demonstrate that when given intravenously temozolomide crosses BTB at a relatively low amount while Herceptin failed to cross the BTB. However, MS co-infusion with [(14)C]-temozolomide or fluorescently labeled-Herceptin resulted in improved and selective drug delivery to brain tumor. We also showed that combination treatment with temozolomide and Herceptin has enhanced anti-tumor effect which was more prominent than that of either treatment alone in increasing the survival in mice with GBM when co-infused with MS. Therefore, brain tumor patients may be benefited when anti-neoplastic agent delivery is increased selectively to the brain tumors using KATP channel agonists.
Published: 2009
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50. Multicellular spheroids as an in vitro model in experimental oncology: applications in translational medicine.

Author: Khaitan D and Dwarakanath BS
Abstract: Multicellular tumour spheroids (MCTS), the best-described three-dimensional tumour model, offers an excellent in vitro screening system, which to a great extent mimics the microenvironment prevailing in the tumour tissue, supporting studies on such tumour specific processes such as angiogenesis, invasion and metastasis and the assessment of responses to various therapies as well as their underlying mechanisms. Developed as an alternative in vitro model to monolayer cultures, nearly 30 years ago, their role as part of high-throughput cell-based assay system in drug discovery is gaining considerable importance. The distinct possibility of establishing MCTS from primary tumour cells and co-culturing with different normal cells, namely stromal fibroblasts, endothelial cells and cells of hemopoietic as well as immune system lineage, enhance the value of MCTS in cancer research and drug development. Here, the authors present a brief overview on the present status on the application of multicellular spheroids in experimental oncology, particularly from the view point of cancer therapy and drug development.
Published: 2006
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