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4. PISA: new design methods for offshore wind turbine monopiles

Author

BW Byrne, RA McAdam, HJ Burd, GT Houlsby, CM Martin, WJAP Beuckelaers, L Zdravkovic, DMG Taborda, DM Potts, RJ Jardine, E Ushev, T Liu, D Abadias, K Gavin, D Igoe, P Doherty, J Skov Gretlund, M Pacheco Andrade, A Muir Wood, FC Schroeder, S Turner, MAL Plummer, and DONG Energy Wind Power A/S

Subjects
Engineering, Offshore wind power, Soil test, business.industry, business, Design methods, Pile, Turbine, Medium scale, Marine engineering
Abstract

Improved design of laterally loaded monopiles is central to the development of current and future generation offshore wind farms. Previously established design methods have demonstrable shortcomings requiring new ideas and approaches to be developed, specific for the offshore wind turbine sector. The Pile Soil Analysis (PISA) Project, established in 2013, addresses this problem through a range of theoretical studies, numerical analysis and medium scale field testing. The project completed in 2016; this paper summarises the principal findings, illustrated through examples incorporating the Cowden stiff clay profile, which represents one of the two soil profiles targeted in the study. The implications for design are discussed.

Published
2017

6. NEUROPSYCHOLOGY

Author

T. Brinkman, W. Liu, G. Armstrong, A. Gajjar, T. Merchant, C. Kimberg, L. Kun, D. K. Srivastava, J. Gurney, L. Robison, M. Hudson, K. Krull, J. Rubens, R. R. Lulla, J.-S. Lai, J. Fangusaro, K. Wolfe, A. Madan-Swain, A. Reddy, G. Hunter, J. Banos, R. Kana, A. Resch, K. von Hoff, A. O. von Buren, C. Friedrich, W. Treulieb, C. Lindow, R. Kwiecien, H. Ottensmeier, S. Rutkowski, C. L. Armstrong, P. C. Phillips, R. A. Lustig, C. Stamos, Y. Li, J. Belasco, J. E. Minturn, M. J. Fisher, T. Heinks-Maldonado, K. Wingeier, V. Lory, C. Schafer, M. Studer, M. Steinlin, K. Leibundgut, M. de Ruiter, N. Schouten, J. Greidanus, M. Grootenhuis, J. Oosterlaan, A. L.-V. A, J. Grill, S. Puget, C. Sainte-Rose, C. Dufour, V. Kieffer, G. Dellatolas, E. B. -Shkedi, M. W. Ben Arush, H. Kaplinsky, S. Ash, Y. Goshen, I. Yaniv, I. J. Cohen, J. M. Levy, T. Tello, X. Lu, D. Gao, G. Wilkening, A. Donson, N. Foreman, A. Liu, J. Korzeniewska, B. D. Baginska, D. Perek, S. Staccioli, D. Chieffo, M. Petrarca, I. Moxon-Emre, M. Taylor, E. Bouffet, D. Malkin, C. Hawkins, N. Scantlebury, D. Mabbott, T. Cunningham, J. Piscione, D. Igoe, M. Orfus, U. Bartels, S. Laughlin, U. Tabori, K. Hardy, B. Carlson-Green, H. Conklin, C. Dockstader, F. Wang, S. Bostan, F. Liu, P. Zou, H. M. Conklin, R. K. Mulhern, R. W. Butler, R. J. Ogg, T. Diver, P. Manley, M. Kieran, C. Chordas, C. Liptak, B. Delaney, S. Brand, and C. Rey-Casserly

Subjects
Abstracts, Cancer Research, Oncology, Neurology (clinical)
Published
2012
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7. Ebola Virus Disease--An Opportunity in Crisis?

Author

R, Glynn, D, Igoe, and M, Boland

Subjects
Africa, Western, Communicable Disease Control, Civil Defense, Humans, Public Health, Hemorrhagic Fever, Ebola, Ireland, Disease Outbreaks
Published
2015

8. 16th All Ireland social medicine meeting

Author

M. S. Henry, M. Gifford, G. J. Bourke, L. E. Daly, P. N. Kirke, G. Bury, E. Shelley, C. Collins, I. Graham, L. Daly, E. McCrum, J. Yarnell, A. Evans, E. Mitchell, C. O’Neill, L. Thornton, C. Gogan, P. McKenna, S. Harding, A. Kelly, H. Sinclair, S. Allwright, Z. Johnson, K. M. O’Kane, D. O’Reilly, J. S. Reid, C. Keenaghan, I. B. A. Menown, D. McCboyle, J. D. S. Higginson, C. Patterson, M. Shields, J. McMahon, P. Fitzpatrick, N. Corcoran, J. Fitzpatrick, R. Salmon, S. R. Palmer, M. Thalanany, M. Manche, R. Roberts, P. Hunter, B. Molloy, R. Meleady, P. Gallagher, D. Shields, A. S. Whitehead, D. McMaster, R. Rozen, D. Igoe, V. Delaney, L. Doherty, B. Farrell, and P. Harte

Subjects
Social medicine, business.industry, Library science, Medicine, General Medicine, business
Published
1998
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9. A survey of Irish palliative care services

Author

D. Igoe, F. Keogh, and C. McNamara

Subjects
Adult, Male, medicine.medical_specialty, Palliative care, Population, Staffing, Nursing, Irish, Neoplasms, medicine, Humans, National Policy, education, Aged, Response rate (survey), Service (business), Health Services Needs and Demand, education.field_of_study, business.industry, Palliative Care, Workload, General Medicine, Middle Aged, language.human_language, Family medicine, Costs and Cost Analysis, language, Female, business, Ireland, Forecasting
Abstract

There has been no national policy directing the development of palliative care services in Ireland. Over the last 25 years different palliative care services have been established around the country, due largely to a strong and concerted effort on the part of voluntary groups. A study was carried out to determine the structure and process of all adult palliative care services in Ireland, to determine, where possible, the costs of providing these services and to assess the need for palliative care services in Ireland. All adult palliative care services (24 home care services, three inpatient services and one acute hospital service) in existence at the end of 1993 were circulated and 26 returns received (response rate 93 per cent). Twenty-five counties were covered by palliative care services, serving approximately three-quarters of the national population. Less than 10 per cent of patients had non-cancer diagnoses. Wide variation in staffing levels, workload, travelling, assessment of need and finance arrangements was reported. There is a need for further debate on the breadth and scope of palliative care services that should ideally be provided in Ireland, and how they should be funded in the future.

Published
1997
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10. National scientific medical meeting 1995 abstracts

Author

S. Norris, C. Collins, J. Hegarty, C. O’Farrelly, J. Carton, L. Madrigal, D. P. O’Donoghue, H. Holloway, J. F. Fielding, W. Mullins, S. W. Hone, M. Donnelly, F. Powell, A. W. Blayney, E. A. Cahill, S. F. Daly, M. J. Turner, P. A. Sullivan, M. McLoughlin, M. M. Skelly, H. E. Mulcahy, T. Connell, C. Duggan, M. J. Duffy, A. Troy, K. Sheahan, A. Whelan, C. M. Herra, C. T. Keane, H. Johnson, B. Lee, E. Doherty, T. McDonnell, D. Mulherin, O. FitzGerald, B. Bresnihan, H. M. Hassett, A. Boyce, V. Greig, C. O’Herlihy, P. P. A. Smyth, E. F. Roche, I. McCormack, E. Tempany, M. J. Cullen, D. F. Smith, Y. McBrinn, B. Murray, R. Freaney, D. Keating, M. J. McKenna, J. A. O’Hare, H. Alam, Q. Raza, M. Geoghegan, S. Killalea, M. Hall, J. Feely, L. Kyne, B. O’Hara, M. Cullen, I. M. Rea, J. P. Donnelly, R. W. Stout, P. Lacey, M. J. Donnelly, J. McGrath, T. P. Hennessy, C. V. I. Timon, D. Hyde, H. X. Xia, M. Buckley, C. O’Morain, S. Keating, H. Xia, J. P. McGrath, R. C. Stuart, P. Lawlor, P. J. Byrne, T. N. Walsh, T. P. J. Hennessy, M. Duffy, M. Tubridy, J. Redmond, K. Monahan, R. P. Murphy, D. R. Headon, T. O’Gorman, F. M. O’Reilly, C. Darby, G. M. Murphy, A. Murphy, M. Codd, P. Dervan, D. Lawlor, S. O. Loughlin, N. Flanagan, R. Watson, L. Barnes, C. Kilgallen, E. Sweeney, A. Mynes, D. Mooney, I. Donoghue, O. Browne, J. A. Kirrane, D. McKenna, M. Young, E. O’Toole, S. O’Briain, U. Srinivasan, C. Feighery, N. Leonard, E. Jones, M. A. Moloney, D. G. Weir, M. Lawler, A. O’Neill, H. Gowing, D. Pamphilon, S. R. McCann, G. O’Toole, A. Orren, C. M. Seifer, D. C. Crowley, G. J. Sheehan, T. Deignan, J. Kelly, V. J. Tormey, J. Faul, C. Leonard, C. M. Burke, L. W. Poulter, S. Lynch, G. McEntee, O. Traynor, E. Barry, P. Costello, A. Keavney, R. Willoughby, C. O’Donnell, M. Cahill, A. Earley, P. Eustace, R. Osborne, C. Saidlear, B. Holmes, A. Early, A. P. Moran, A. Neisser, R. J. Polt, H. Bernheimer, M. Kainz, B. Schwerer, L. Gallagher, R. Firth, N. Kennedy, E. McGilloway, N. Tubridy, K. Shields, W. K. Cullen, M. J. Rowan, A. R. Moore, M. Rowan, D. Coakley, B. Lawlor, G. Swanwick, R. Al-Naeemi, R. Murphy, N. M. Codd, M. Goggins, N. P. Kennedy, B. L. Mallon, H. Mulcahy, M. Skelly, D. O. Donoghue, D. McCarthy, A. Saunders, D. J. Veale, J. J. F. Belch, D. Breathnach, E. Murphy, G. Kernohan, K. Gibson, A. G. Wilson, G. W. Duff, N. de Vries, L. B. A. van de Putte, J. Donoghue, F. O’Kelly, Z. Johnson, T. Maher, A. Moran, C. Keane, D. O’Neill, N. Horgan, J. M. Barragry, D. M. Campbell, M. Behan, P. R. O’Connell, V. S. Donnelly, D. Crowley, M. Geary, P. Boylan, M. Fanagan, K. Hickey, T. Teoh, M. Doyle, R. Harrison, D. Lyons, Y. Shenouda, M. Coughlan, P. McKenna, P. Lenehan, M. Foley, P. Kelehan, P. Ravichandran, M. Kelly, A. Conroy, C. Fitzpatrick, D. Egan, C. L. Regan, B. V. McAdam, P. McParland, G. A. FitzGerald, D. J. Fitzgerald, S. C. Sharma, K. Foran, C. Barry-Kinsella, R. F. Harrison, F. J. Gillespie, P. O’Mahony, M. Boyle, M. J. White, F. Donohoe, Y. Birrane, M. Naughton, R. B. Fitzsimons, M. Piracha, S. McConkey, E. Griffin, E. Hayes, T. Clarke, N. Parfrey, K. Butler, A. J. Malone, P. J. Kearney, P. F. Duggan, A. Lane, R. Keville, M. Turner, S. Barry, D. Sloan, S. Gallagher, M. Darby, P. Galligan, J. Stack, N. Walsh, M. O’Sullivan, M. Fitzgerald, D. Meagher, S. Browne, C. Larkin, P. Casey, E. O’Callaghan, S. Rooney, E. Walsh, M. Morris, T. Burke, M. Roe, C. Maher, M. Wrigley, M. Gill, M. Burgess, E. Corcoran, D. Walsh, B. Gilmer, C. B. Hayes, L. Thornton, J. Fogarty, R. Lyons, M. O’Connor, V. Delaney, K. Buckley, D. Lillis, V. Delany, C. Hayes, P. Dack, D. Igoe, H. J. O’Neill, P. Kelly, D. McKeown, L. Clancy, G. Varghese, S. Hennessy, J. J. Gilmartin, K. Birthistle, D. Carrington, H. Maguire, P. Atkinson, C. Foley-Nolan, M. Lynch, B. Cryan, D. Whyte, C. Conlon, V. Kucinskas, U. Usinskiene, I. Sakalyte, E. Dawson, K. Molloy, N. Goulden, J. Doyle, E. Lawlor, M. G. Harrington, N. El-Nageh, M. -L. Nolan, J. O’Riordan, G. Judge, G. Crotty, T. Finch, M. Borton, T. Barnes, O. Gilligan, G. Lee, R. Limmer, M. Madden, C. Bergin, A. O’Leary, F. Mulcahy, F. Wallis, M. Glennon, M. Cormican, U. NiRiain, M. Heiginbothom, F. Gannon, T. Smith, C. O’Sullivan, R. Hone, D. A. Caugant, C. A. P. Fijen, E. J. Van Schalkwyk, G. J. Coetzee, U. Ni Riain, M. G. Cormican, L. Park, J. Flynn, V. Regazzoli, M. Hayes, G. Nicholson, P. Higgins, N. Flynn, G. Corbett-Feeney, D. J. Conway, N. J. O’Higgins, S. Rajendiran, J. Byrne, E. Kilfeather, P. Dingle, M. Hunter, S. K. Al-Ghazal, P. Stanley, J. Palmer, A. Hong, P. Saxby, D. Sheehan, I. Regan, J. O’Mullane, M. Ni Chaoimh, M. Leahy, J. J. Heffron, M. Lehane, C. Keohane, N. O’Leary, M. Sheehan, E. Renny-Walsh, M. J. Whelton, C. T. Doyle, J. Webster, N. Benjamin, S. FitzGerald, J. S. Chadha, M. G. FitzGerald, G. R. FitzGerald, L. Hemeryck, P. McGettigan, J. Golden, N. Arthur, S. Y. Wen, P. Deegan, T. Cooke, G. I. Adebayo, P. Gaffney, M. Sinnot, D. O’Riordan, T. Hayes, C. M. O’Connor, M. X. FitzGerald, C. Costello, G. Finlay, J. Hayes, C. O’Connor, K. McMahon, S. Hone, J. Robertson, R. Coakley, S. O’Neill, M. Walsh, J. McCarthy, D. Lannon, A. E. Wood, R. Sharkey, E. Mulloy, M. Long, I. Kilgallen, V. Tormey, S. Horne, T. Feeney, Ó. Ó Muiré, M. J. Griffin, D. Hughes, A. Knaggs, D. Magee, C. McCrory, B. March, D. Phelan, M. White, J. Fabry, D. Buggy, C. Cooney, E. Aziz, D. O’Keefe, A. J. McShane, J. Boylan, E. Tobin, C. Motherway, F. Colreavy, N. Denish, R. Dwyer, A. Bergin, K. O’Brien, R. MacSullivan, K. D. Carson, W. P. Blunnie, D. C. Moriarty, B. Kinirons, B. Lyons, N. Cregg, W. Casey, K. P. Moore, S. A. Colbert, C. Ecoffey, D. O’Gorman, J. Fitzgerald, P. Diamond, M. B. Codd, D. D. Sugrue, J. Kellett, M. Tighe, C. J. McKenna, J. Galvin, H. A. McCann, A. Scallon, A. Fraser, M. Norton, G. Tomkin, I. Graham, A. Byrne, M. Maher, N. Moran, D. Fitzgerald, D. O’Callaghan, D. Coyle, A. G. Nugent, C. McGurk, G. D. Johnston, A. Nugent, B. Silke, N. Murphy, L. Jennings, D. Pratico, C. Doyle, T. Hennessy, H. McCann, D. Sugrue, S. Donnelly, A. Hennessy, C. Hartigan, D. MacDonald, S. Blake, D. McDonald, D. Dominque, S. R. McMechan, G. MacKenzie, J. Allen, G. T. Wright, G. J. Dempsey, M. Crawley, J. Anderson, A. A. J. Adgey, M. T. Harbinson, N. P. S. Campbell, C. M. Wilson, P. K. Ellis, E. M. McIlrath, A. McShane, T. V. Keaveny, K. Rabenstein, F. Scheller, D. Pfeiffer, C. Urban, I. Moser, G. Jobst, A. Manz, S. Verpoorte, F. Dempsey, D. Diamond, M. Smyth, E. Dempsey, V. Hamilton, J. Twomey, R. Crowley, L. Fenelon, F. Walsh, J. McCann, P. McDonagh, E. McGovern, D. Luke, K. Crowley, D. Mannion, D. Murphy, K. Clarkson, E. Carton, I. Leonard, D. O’Toole, M. Staunton, M. Griffin, D. Owens, P. Collins, A. Johnson, G. H. Tomkin, N. A. Herity, J. D. Allen, R. O’Moore, G. M. Crotty, M. DeArce, K. Nikookam, P. Keenan, D. Cregan, N. O’Meara, S. Forman, D. A. Cusack, and B. Farrell

Subjects
medicine.medical_specialty, business.industry, Family medicine, medicine, MEDLINE, General Medicine, business
Published
1995
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11. QUALITY OF LIFE/AFTERCARE

Author

S. Rednam, M. Scheurer, A. Adesina, C. Lau, M. Okcu, J. Deatrick, S. Ogle, M. Fisher, L. Barakat, T. Hardie, Y. Li, J. Ginsberg, M. Ben-Arush, E. Krivoy, R. Rosenkranz, M. Peretz-Nahum, R. J. Brown, J. Love, D. Warburton, W. H. McBride, S. Bluml, S. Mueller, K. Sear, N. Hills, N. Chettout, S. Afghani, L. Lew, E. Tolentino, D. Haas-Kogan, H. Fullerton, W. Reddick, S. Palmer, J. Glass, R. Ogg, A. Gajjar, A. Omar, S. Perkins, E. Shinohara, D. Spoljaric, J. Isenberg, M. Whittington, M. Hauff, A. King, K. Litzelman, E. Barker, K. Catrine, D. Puccetti, P. Possin, W. Witt, C. Mallucci, R. Kumar, B. Pizer, D. Williams, B. Pettorini, J. Piscione, E. Bouffet, I. Shams, A. Kulkarni, T. Remes, A. Harila-Saari, M. Suo-Palosaari, P. Arikoski, P. Riikonen, A. Sutela, P. Koskenkorva, M. Ojaniemi, H. Rantala, C. J. Campen, D. Ashby, P. G. Fisher, M. Monje, A. V. Kulkarni, H. Nakamura, K. Makino, S. Yano, J.-i. Kuratsu, F. Jadrijevic-Cvrlje, M. Batinica, H. Toledano, T. Hoffman, Y. Ezer-Cohen, S. Michowiz, I. Yaniv, I. J. Cohen, I. Adler, S. Mindel, M. Gopalakrishnamoorthy, D. Saunders, M. Gaze, H. Spoudeas, V. Kieffer, G. Dellatolas, M. Chevignard, S. Puget, F. Dhermain, J. Grill, C. Dufour, R. Muir, A. Hunter, A. Latchman, O. de Camargo, K. Scheinemann, N. Dhir, W. Zaky, T. Zomorodian, K. Wong, G. Dhall, M. Macy, C. Lauro, P. Zeitler, N. Foreman, A. Liu, M. Chocholous, P. Dodier, A. Peyrl, K. Dieckmann, G. Hausler, I. Slavc, S. Avula, D. Garlick, G. Armstrong, T. Kawashima, W. Leisenring, M. Stovall, C. Sklar, L. Robison, C. Samaan, J. Duckworth, N. Greenberg-Kushnir, S. Freedman, R. Eshel, N. Zverling, R. Elhasid, R. Dvir, M. Yalon, S. Constantini, S. Wilne, J.-F. Liu, J. Trusler, S. Lundsell, C. Kennedy, L. Clough, N. Dickson, M. Lakhanpaul, M. Baker, J. Dudley, R. Grundy, D. Walker, K. von Hoff, N. Herzog, H. Ottensmeier, D. Grabow, N. U. Gerber, C. Friedrich, A. O. von Bueren, A. Resch, R. D. Kortmann, P. Kaatsch, H. G. Doerr, S. Rutkowski, F. del Bufalo, A. Mastronuzzi, A. Serra, L. de Sio, F. Locatelli, V. Biassoni, M. Leonardi, D. Ajovalasit, D. Riva, C. Vago, A. Usilla, P. Fidani, E. Schiavello, F. Gariboldi, M. Massimino, R. Lober, S. Perrault, S. Partap, M. Edwards, P. Fisher, K. Yeom, D. Salgado, S. Nunes, S. Vinhais, E. M. Wells, K. Seidel, N. J. Ullrich, L. Diller, K. R. Krull, J. Neglia, L. L. Robison, K. Whelan, C. E. Russell, D. Brownstone, C. Kaise, K. Bull, D. Culliford, G. Calaminus, D. Bertin, S. Vallero, E. Romano, M. E. Basso, E. Biasin, F. Fagioli, K. Ziara, A. L'Hotta, A. Williams, R. Thede, K. Moore, A. James, E. Bjorn, P. Franzen, A. Haag, A.-K. Lax, I. Moreno, J. Obeid, B. W. Timmons, W. Iwata, S. Wagner, J.-S. Lai, K. Waddell, S. VanLeeuwen, M. Newmark, J. Noonan, K. O'Connell, M. Urban, S. Yount, S. Goldman, D. Igoe, T. Cunningham, M. Orfus, D. Mabbott, C. Liptak, P. Manley, C. Recklitis, P. Zhang, F. Shaikh, I. Narang, K. Matsumoto, K. Yamasaki, K. Okada, H. Fujisaki, Y. Osugi, J. Hara, K. Phipps, D. Gumley, T. Jacques, D. Hargrave, A. Michalski, C. Chordas, S. Chi, N. Robison, P. Bandopadhayay, K. Marcus, M. A. Zimmerman, L. Goumnerova, M. Kieran, S. Brand, T. Brinkman, B. Delaney, T. Diver, C. Rey, J. R. Madden, M. S. Hemenway, L. Dorneman, D. Stiller, A. K. Liu, N. K. Foreman, R. Vibhakar, M. Mitchell, M. Hemenway, J. Madden, M. Ryan, R. O'Kane, S. Picton, T. Kenny, C. Stiller, P. Chumas, A. Bendel, R. Patterson, M. Barrera, F. Schulte, U. Bartels, L. Janzen, D. Johnston, D. Cataudella, J. Chung, L. Sung, K. Hancock, J. Hukin, S. Zelcer, S. Brandon, I. Montour-Proulx, D. Strother, R. Cooksey, D. Bowers, L. Gargan, A. Gode, L. Klesse, J. Oden, G. Vega, F. Sala, D. Nuzzi, M. Mulino, B. Masotto, C. Mazza, A. Bricolo, M. Gerosa, M. Tong, S. Laughlin, S. Mackie, L. Taylor, G. Sharpe, O. Al-Salihi, and G. Nicolin

Subjects
Oncology, Medulloblastoma, Cancer Research, medicine.medical_specialty, Chemotherapy, business.industry, medicine.medical_treatment, Amifostine, Multimodality Therapy, medicine.disease, Clinical trial, Abstracts, Ototoxicity, Primitive neuroectodermal tumor, Internal medicine, Immunology, medicine, Neurology (clinical), Adverse effect, business, medicine.drug
Abstract

BACKGROUND: Glutathione S-transferase (GST) enzymes are involved in detoxifying chemotherapy agents and clearing reactive oxygen species formed by radiation. In this study, we explored the relationship between the host GSTP1-105 polymorphism (rs1695), tumor GSTpi protein expression, and clinical outcomes in pediatric medulloblastoma. We hypothesized that the GSTP1-105 G-allele and increased tumor GSTpi expression would be associated with lower progression-free survival and fewer adverse events. METHODS: The study included 106 medulloblastoma/primitive neuroectodermal tumor (PNET) patients seen at Texas Children’s Cancer Center. Genotyping was performed using an Illumina HumanOmni1-Quad BeadChip and tumor GSTpi expression was assessed using immunohistochemistry. We used the Kaplan-Meier method for survival analyses and multivariable logistic regression for toxicity comparisons. RESULTS: Patients with a GSTP1-105 AG/GG genotype or who had received a higher dose of craniospinal radiation (median 36 Gy) had a greater risk of requiring hearing aids than their respective counterparts (OR 4.0, 95%CI 1.2 - 13.6, and OR 3.1, 95%CI 1.1 - 8.8, respectively). Additionally, there was a statistically significant interaction between the two variables. Compared with the lowest risk group (GSTP1-105 AA-lower dose radiation) patients with a GSTP1-105 AG/GG genotype who received a higher dose radiation were 8.4 times more likely to require hearing aids (95%CI 1.4 - 49.9, p-trend ¼ 0.005). When adjusted for age, gender, and amifostine use, the association remained. CONCLUSIONS: The GSTP1-105 G-allele is associated with permanent ototoxicity in pediatric medulloblastoma/PNET and strongly interacts with radiation dose. A possible mechanism for this finding is that the GSTP1-105 G-allele leads to reduced GSTpi free radical detoxification in the setting of multimodality therapy including cisplatin and radiation. Patients with this allele should be considered for clinical trials employing radiation dose modifications and more targeted cytoprotectant strategies than are currently being used with amifostine.

Published
2012

12. Sex steroids, adiposity and smoking in the pathogenesis of idiopathic hirsutism and polycystic ovary syndrome

Author

D. Igoe, T. J. McKenna, B. Byrne, S K Cunningham, and Ronan M. Conroy

Subjects
Adult, Hirsutism, medicine.medical_specialty, Estrone, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Body Mass Index, chemistry.chemical_compound, Endocrinology, Sex Hormone-Binding Globulin, Internal medicine, Adrenal Glands, Humans, Medicine, Testosterone, Obesity, Androstenedione, Aromatase, Gonadal Steroid Hormones, hirsutism, Retrospective Studies, biology, Dehydroepiandrosterone Sulfate, business.industry, Body Weight, Smoking, Estrogens, Dehydroepiandrosterone, General Medicine, medicine.disease, Androgen, Polycystic ovary, chemistry, Estrogen, Androgens, biology.protein, Female, business, Polycystic Ovary Syndrome
Abstract

Hyperestronemia may be central to the development of polycystic ovary syndrome. The present study was designed to examine whether increased availability of androstenedione or increased aromatase closely associated with adiposity, plays the dominant role in the development of hyperestronemia. We measured plasma androstenedione, estrone and the estrone/androstenedione ratio (an indirect index of peripheral aromatase activity), in 141 patients with idiopathic hirsutism and in 88 patients with polycystic ovary syndrome. Estrone levels were higher in polycystic ovary syndrome, 250.4±129 (mean ± standard deviation) than in idiopathic hirsutism, 210.6±119 pmol/l, p2, p

Published
1991
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13. Irish endocrine society

Author

C. H. Walsh, A. L. Murphy, S. Cunningham, T. J. McKenna, B. Byrne, D. Igoe, S. K. Cunningham, M. Culliton, C. Costigan, J. A. McKnight, D. R. McCance, G. Roberts, B. Sheridan, A. B. Atkinson, O. Lanigan, P. O’Leary, T. Moran, P. P. A. Smyth, D. R. Hadden, L. Kennedy, D. Foley-Nolan, A. Foley-Nolan, D. Temperley, J. Devlin, P. M. Bell, R. D. G. Neely, D. P. Rooney, E. R. Trimble, J. D. M. Edgar, R. Doherty, A. B. Atkinsion, J. A. O’Hare, L. Rand, A. Krolewski, C. McKenna, J. McKieman, H. M. Whitehead, K. Buchanan, Davina Fillmore, Joy Ardill, C. Johnston, Wendy Robinson, G. Silvestri, J. A. Dunn, D. G. Dwyer, J. W. Baynes, T. J. Lyons, D. Owens, J. Stinson, P. Collins, A. Johnson, G. Tomkin, D. F. Smith, D. O’Carroll, M. Murray, N. J. O’Higgins, A. M. Hetherton, T. B. Counihan, D. B. R. Poole, D. K. O’Donovan, H. Grimes, and J. O’Donnell

Subjects
Metyrapone, business.industry, Physiology, General Medicine, Renal artery stenosis, medicine.disease, Plasma renin activity, language.human_language, Irish, medicine, language, Endocrine system, business, medicine.drug
Published
1990
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14. Avian influenza and the risk to human health

Author

D, O'Flanagan, D, Igoe, and J, O'Donnell

Subjects
Birds, Travel, Influenza A virus, Influenza in Birds, Zoonoses, Influenza, Human, Animals, Humans, Disease Outbreaks
Published
2006

15. Acute gastroenteritis in northern Ireland and the Republic of Ireland: a telephone survey

Author

E, Scallan, M, Fitzgerald, C, Collins, D, Crowley, L, Daly, M, Devine, D, Igoe, T, Quigley, T, Robinson, and B, Smyth

Subjects
Adult, Male, Adolescent, Northern Ireland, Middle Aged, Patient Acceptance of Health Care, Health Surveys, Gastroenteritis, Telephone, Cost of Illness, Child, Preschool, Population Surveillance, Absenteeism, Acute Disease, Humans, Female, Child, Ireland, Aged
Abstract

Most people with acute gastroenteritis do not seek medical care and are therefore not captured by routine surveillance. For this reason, population-based studies are needed to measure the burden of illness. A study of acute gastroenteritis in Northern Ireland and the Republic of Ireland surveyed 9,903 people by telephone over the 12-month period from December 2000 to November 2001. The rate of acute gastroenteritis was 0.60 episodes per person per year. A general practitioner was consulted by 29.2% of those reporting illness, and 2.0% submitted a stool sample. The use of antibiotics was reported by 7.4% of ill respondents and 14.8% took anti-diarrhoeals. Taking days off work due to illness, was reported by 17.4% of respondents. Acute gastroenteritis causes a large amount of illness in the community. There are established and effective measures to prevent this condition and the challenge is to find new ways of promoting these precautions.

Published
2004

16. Results of the first population based telephone survey of acute gastroenteritis in Northern Ireland and the Republic of Ireland

Author

Margaret Fitzgerald, Leslie Daly, D. Crowley, D Igoe, Elaine Scallan, Thomas Quigley, Barry Smyth, Claire Collins, and Devine M

Subjects
Telephone survey, medicine.medical_specialty, business.industry, Economic cost, Family medicine, Medicine, Medical emergency, Population based, Northern ireland, Acute gastroenteritis, business, medicine.disease
Abstract

Acute gastroenteritis is a common, though often preventable illness. It is associated with substantial social and economic costs. The true burden of acute gastroenteritis is often underestimated

Published
2004
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17. Unexplained illness among injecting drug users in Dublin: a case-control study

Author

D Igoe, Mary Ward, Joseph Barry, K Murray, Eamon Keenan, and Louise Mullen

Subjects
Adult, Male, medicine.medical_specialty, Circulatory collapse, Epidemiology, Short Report, Injections, Intramuscular, Heroin, Disease Outbreaks, Wound Botulism, Risk Factors, medicine, Odds Ratio, Humans, Prospective Studies, Risk factor, Substance Abuse, Intravenous, Communicable disease, Tetanus, business.industry, Public Health, Environmental and Occupational Health, Outbreak, medicine.disease, Surgery, Case-Control Studies, Emergency medicine, Clostridium Infections, Female, business, Ireland, medicine.drug
Abstract

An outbreak of unexplained illness among heroin users was reported in May 2000 in Dublin. Between 29 April and 26 June 2000, 22 cases were identified, with eight deaths. This occurred in association with similar outbreaks in the UK, particularly Glasgow. Illness was characterised by soft tissue inflammation at the injection site, followed by hypotension and circulatory collapse. Laboratory results indicated that clostridium species were associated with the outbreaks. Analysis of cases in the UK indicate increased risk for female injectors and longer term users. However, data on injecting practice were unavailable. Injecting intramuscularly has been associated with outbreaks of wound botulism and tetanus. A prospective case-control study was initiated to identify risk factors associated with this outbreak.

Published
2002

18. Tuberculosis in the Republic of Ireland at the end of the 1990s

Author

A, Smith, D, O'Flanagan, and D, Igoe

Subjects
Adult, Male, Adolescent, Child, Preschool, Incidence, Humans, Tuberculosis, Female, Middle Aged, Child, Ireland, Tuberculosis, Pulmonary, Aged
Abstract

There has been limited detailed epidemiological data available on tuberculosis in the Republic of Ireland. The 1998 and 1999 National TB Reports produced by the National Disease Surveillance Centre presented disaggregate national data describing in detail the epidemiology of TB in the Republic of Ireland. Individual case notifications were collated by health boards, forwarded to NDSC where they were entered onto a national TB database and then analysed using Epi-Info. There were 893 cases of TB notified in 1998-1999. It was more common in older age groups and men. 50% of cases occurred in those less than 45 years, an indication of considerable ongoing transmission of tuberculosis. Regional variation in the rate of TB exists and a relatively small proportion of cases occurred in foreign-born patients. TB in HIV positive patients was not common and MDR-TB has also been observed. TB has not disappeared from the Republic of Ireland. Treatment, contact tracing and surveillance need to be maintained and preferably enhanced.

Published
2002

19. Outbreak of Vero cytotoxin-producing Escherichia coli O157 in a child day care facility

Author

J M, O'Donnell, L, Thornton, E B, McNamara, T, Prendergast, D, Igoe, and C, Cosgrove

Subjects
Adult, Male, Time Factors, Infant, Child Day Care Centers, Escherichia coli O157, Shiga Toxin 1, United Kingdom, Disease Outbreaks, Feces, Risk Factors, Child, Preschool, Humans, Female, Child, Escherichia coli Infections
Abstract

In December 1998, an outbreak of Vero cytotoxin-producing Escherichia coli (VTEC) O157 in a crèche affected ten out of 45 children and one out of five staff members. Eight cases were symptomatic and three were asymptomatic. There were two asymptomatic adult family contacts of child cases. All specimens were identified as VTEC O157:H7, phage type 32. None of the cases were seriously ill and none developed haemolytic uraemic syndrome (HUS). One child continued to excrete the organism for 14 weeks. The origin of the outbreak was not found but epidemiological investigation was suggestive of person-to-person spread. All children and staff were screened and excluded from the crèche until microbiological clearance was obtained. An inspection of the crèche revealed overcrowding and inadequacies in cleaning and in the food preparation facilities. These problems were remedied before children were re-admitted to the crèche. This outbreak demonstrates the ease with which VTEC O157 can be transmitted between small children. Two specific features of this outbreak were notable: (1) the mild self-limiting nature of the illness and (2) the prolonged shedding of the bacterium by one child.

Published
2002

20. Outcome of medical screening of Kosovan refugees in Ireland: 1999

Author

A, Smith, D, O'Flanagan, D, Igoe, J, Cronin, D, Forde, E, McArdle, and D, Ko

Subjects
Male, Refugees, Vaccination, Yugoslavia, Infant, Hepatitis B, Treatment Outcome, Child, Preschool, Albania, Humans, Mass Screening, Female, Child, Ireland, Tuberculosis, Pulmonary, Immunization Schedule
Abstract

In March 1999 armed conflict broke out in Kosova and about 900,000 ethnic Albanians were displaced. We reviewed the health care offered to the 945 Kosovan refugees who arrived in Ireland in 1999, which included screening for tuberculosis (TB) and hepatitis B. On arrival in Ireland 540 refugees had already received oral polio vaccine (57%), 512 diphtheria, tetanus, and acellular pertussis or diphtheria and tetanus vaccine (54%), 310 BCG (33%), 207 measles, mumps, and rubella vaccine (22%) and 60 Haemophilus influenzae type b (6%). Twelve refugees were diagnosed with TB. Twenty-six refugees were HBsAg positive (3%) and 168 were anti-HBcAg positive (18%). Organised screening of Kosovan refugees on a voluntary basis (uptake95%) revealed low percentages who had been immunised and relatively high rates of TB and hepatitis B. The provision of optimum immunisation, screening, and treatment services to address these issues requires substantial staffing and financial resources.

Published
2001

21. TSH as an index of L-Thyroxine replacement and suppression therapy

Author

T. J. McKenna, D. Igoe, and Michael J. Duffy

Subjects
Adult, Male, endocrine system, medicine.medical_specialty, Goiter, endocrine system diseases, Thyrotropin, Endogeny, TRH stimulation test, Hypothyroidism, Internal medicine, medicine, Humans, Euthyroid, Thyroid Neoplasms, Normal range, Aged, business.industry, Thyroid, Primary hypothyroidism, Cancer, General Medicine, Middle Aged, medicine.disease, Thyroxine, Endocrinology, medicine.anatomical_structure, Female, Drug Monitoring, business, hormones, hormone substitutes, and hormone antagonists
Abstract

When hypothalamic-pituitary function is normal, serum TSH levels measured by ultrasensitive assay yield bioassays of endogenous thyroid action and thus provide an ideal index of thyroid secretion and its relationship to fluctuating endogenous thyroid levels. It is theoretically possible that patients receiving exogenous L-thyroxine for primary hypothyroidism should have suppressed TSH levels if physiological needs are constantly met. To examine this possibility free thyroxine, FT4 and TSH were measured in 90 clinically euthyroid patients receiving treatment with L-thyroxine for primary hypothyroidism. TSH levels were normal in 44, suppressed in 16 and elevated in 30 patients. FT4 levels were normal in 68, elevated in 13 and suppressed in 9 patients. Normal TSH levels were associated with normal FT4 levels in 79.5% of patients, elevated FT4 levels in 13.6% and low FT4 in 6.8%. Suppressed TSH levels were associated with elevated FT4 levels in 37.5% of patients and normal FT4 levels in 62.5%. When FT4 levels were normal, however, TSH levels were normal in only 51.5% and abnormal in 48.5%. We also examined the possibility that FT4 levels may remain within normal range when TSH is suppressed during L-thyroxine treatment for goitre or cancer. FT4 and TSH were measured in 45 patients on L-thyroxine as TSH suppression treatment. TSH was suppressed in 23 patients (51.1%), normal in 20 (44.4%) and elevated in 2 (4.5%). When TSH was suppressed, FT4 was elevated in 30.4% but normal in 69.6% of patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1992
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22. Selected abstracts

Author

P. P. Corkery, B. F. Leek, B. Caulfield, M. Garrett, J. P. Gormley, P. M. O’Donnell, N. Kennedy, K. Sayers, E. Stokes, B. Bresnihan, O. Fitzgerald, M. A. McGarvey, M. Tonra, A. C. B. Hooper, J. Barry, B. Maurer, J. Hussey, J. Gormley, J. G. Noble, J. Alves-Guerreiro, A. S. Lowe, D. M. Walsh, B. NicNiocaill, M. Harte, W. T. O’Connor, A. M. O’Hara, A. Orren, A. P. Moran, D. A. Hardiman, T. C. Lee, D. T. Croke, R. Tolan, S. McBennett, S. Warmington, M. McGuire, A. Bradford, T. O’Hare, M. MacDermott, F. Lynch, R. G. O’Regan, P. McLoughlin, T. Quinn, J. P. Ryan, M. Pickering, D. P. Campion, J. F. X. Jones, S. Ryan, W. T. McNicholas, P. Nolan, F. J. Doyle, S. M. Rackard, P. Beddy, V. A. Campbell, Y. S. Bakhle, C. Bell, C. Usher, L. Chan, A. K. Keenan, K. E. McQuaid, V. C. Cullen, E. M. Smith, A. Kelly, M. A. Lynch, D. B. Freir, C. Holscher, C. E. Herron, H. A. Pearson, B. P. Curran, J. J. O’Connor, A. Quinn, J. McHale, D. Moriarty, J. O’Connor, J. C. Glennon, B. J. Van Vliet, S. K. Long, C. Kruse, H. C. Gallagher, C. L. Bacon, B. Boland, A. M. Griffin, J. Preisler, L. O’Brien, C. M. Regan, S. Hurley, P. J. Kearney, J. Slevin, C. Barry-Kinsella, C. A. Ryan, O. Kllleen, J. Glllan, T. Clarke, T. Matthews, D. Corcoran, E. Dunn, M. Geary, C. O’Herlihy, D. Keane, M. M. Slattery, M. J. O’Leary, J. J. Morrison, E. Ryan, W. A. Gorman, A. Bourke, J. Larkin, C. Mayes, J. Jenkins, M. Ryan, S. Lalchandani, O. Sheil, N. Lynch, C. Costigan, J. F. Murphy, R. Bhatia, A. Foran, V. Donohue, P. McParland, P. LaSjaunais, G. Rodesch, M. McGinn, J. McAloon, M. O’Leary, K. Astbury, D. Harmon, A. Sharkey, G. Gaffney, G. O’Regan, C. McMahon, D. Murray, C. McDermott, E. Woolhead, J. Gillan, J. L. Cartmill, M. A. Harper, N. Al-Shabibi, M. Hanahoe, M. Wingfield, J. A. M. Larkin, A. H. Bell, B. G. McClure, L. Sweeney, D. H. Martin, P. O’Donoghue, A. Davoren, G. F. Lucas, J. McKiernan, D. M. T. Gallagher, K. P. Dunne, O. Fulena, M. Sheridan, E. Griffin, M. White, P. Deasy, M. O’Riordan, C. O’Gorman, C. Mongan, M. McCafferkey, G. Henry, P. McKenna, A. O’Malley, D. Devaney, P. Kelleghan, E. E. Mooney, J. E. Gillan, M. Fitzpatrick, K. McQuillan, C. Heffron, P. Hodnett, A. Curtain, T. C. F. O’Connor, T. G. Connell, D. Waldron, W. Gorman, T. Bolger, M. O’Keefe, J. Murphy, L. M. Dolan, A. I. Traub, A. E. Curley, H. L. Halliday, T. R. J. Tubman, O. Kileen, H. Riadha, J. Russell, R. Philips, C. Regan, I. Ali, A. C. J. Coughlan, M. J. Turner, A. Smith, D. O’Flanagan, D. Igoe, F. Ryan, D. Forde, E. McArdle, D. Ko, D. Bedford, M. Hegarty, B. Dunlevy, R. Corcoran, T. Holohan, A. Feeney, H. McGee, W. Shannon, M. Condon, C. Hyland, G. Sayers, E. Feely, D. Crowley, D. O’Reilly, T. O’Connell, M. Cronin, H. Johnson, M. Fitzgeraldi, M. Cafferkey, A. Breslin, C. J. Bonner, B. Foley, M. Fitzgerald, P. G. Wall, E. McNamara, P. Costigan, T. Prendergast, K. Foye, C. Cosgrove, A. Keane, E. Murphy, J. O’Donnell, A. Quinlan, L. Thornton, E. A. Roch, R. A. Lyons, A. Maddocks, P. Barnes, L. Price, M. McCabe, P. Nash, A. Midha, Y. Doyle, A. Kilgallen, P. Wright, T. Ryan, D. De La Harpe, V. Harkins, C. Brennan, V. O’Connell, D. S. Evans, J. Ni Mhuircheartaigh, J. M. O’Donnell, A. Rhatigan, E. Shelley, C. Collins, M. Byrne, A. W. Murphy, P. K. Plunkett, A. Murray, G. Bury, F. Lynam, G. McMahon, T. Greally, D. Kane, D. Veale, R. Reece, S. Busteed, M. W. Bennett, M. Stone, C. Molloy, J. O’Connell, M. G. Molloy, F. Shanahan, J. Guerin, E. Casey, C. Feighery, F. Lin, J. Jackson, A. Pendleton, G. D. Wright, A. E. Hughes, D. O’Gradaigh, I. Debham, J. Compston, A. McEvoy, E. P. Murphy, D. Salonen, P. Payne, M. Lax, V. Lapp, R. Inman, K. O’Rourke, D. Brennan, J. Harty, C. McCarthy, J. O’Byrne, S. Eustace, H. Chirayath, N. W. Liggett, M. P. Morgan, D. J. Fitzgerald, C. J. McCarthy, G. M. McCarthy, R. Z. Lee, K. Wai, D. Nevin, A. O. Leary, R. Lee, E. B. Casey, A. O’Leary, D. Breen, D. Tuite, D. McInerney, R. Sim, A. L. Frederic, O. Smith, B. White, M. Murphy, C. Silke, E. O’Keeffe, N. Fanning, L. Spence, N. A. Parfrey, J. R. McConnell, A. D. Crockard, A. P. Cairns, A. L. Bell, O. Kavanagh, D. A. Moyes, M. Finch, M. Rooney, A. Bell, I. Founas, A. El-Magbri, S. Mooney, M. Kennedy, R. J. Coughlan, S. A. Ramakrishnan, A. Gsel, O. Finnerty, M. Burns, M. Yateman, C. Camaco-Hubner, C. F. Matthews, A. Taggart, K. Fuller, M. S. Murphy, M. Phelan, T. B. Murphy, F. Wynne, K. Quane, M. Daly, J. O’Leary, I. da Silva, N. Bermingham, M. Gogarty, L. P. Gallagher, R. O’Hara, C. Godson, H. Brady, H. Osman, A. El-Rafie, D. Foley-Nolan, P. Kirwan, O. Corcoran, T. Duffy, F. Drummond, A. Madigan, D. Williams, P. Gallagher, C. Hatton, S. Cunningham, O. FitzGerald, P. Minnock, E. Wylie, D. Egan, J. Mc Cormack, M. O. Shea, D. Evans, P. O’Lorcain, H. Comber, A. Evans, J. Jones, C. Garavan, K. Kelleher, M. C. Boland, R. Healy, M. B. O’Sullivan, M. Burke, P. Mc Donald, R. Smithson, J. Glass, C. A. Mason, N. Mullins, D. Nolan, P. McCormick, S. Coughlan, S. Dooley, C. C. Kelleher, A. Hope, F. Murphy, M. Barry, J. Sixsmith, A. MacFarlane, C. MacLeod, G. McElroy, D. O’Loan, F. Kennedy, R. M. Kerr, J. Lim, S. P. A. Allwright, F. L. Bradley, J. M. G. Barry, J. Long, J. V. Parry, D. Creagh, I. J. Perry, A. Collins, S. Neilson, N. Colwell, D. O’Halloran, S. O’Neill, S. McErlain, M. Okasha, B. Gaffney, P. McCarron, R. Hinchion, C. Drew, A. Gavin, D. Fitzpatrick, R. Campbell, S. G. Wannamethee, A. Shaper, S. Friel, C. Kelleher, F. Kee, C. C. Atterson, E. A. Wilson, J. M. McConnell, S. M. Wheeler, J. D. Watson, N. Norashikin Rahman, J. Sheehan, C. Wall, B. Kelleher, S. D. O’Broin, R. N. Mullan, P. J. McKeveney, V. M. Hodges, P. C. Winter, P. Maxwell, D. A. Simpson, T. R. J. Lappin, A. P. Maxwell, J. A. Eustace, J. Coresh, C. Kutchey, P. L. Te, L. F. Gimenez, P. J. Scheel, M. Walser, R. A. McMahon, M. Clarkson, F. Martin, H. R. Brady, C. Blake, Y. M. O’Meara, S. Gupta, H. MacKenzie, S. Doyle, T. Fotheringham, P. Haslam, M. P. Logan, P. Conlon, M. Lee, P. Maderna, D. C. Cottell, S. Mitchell, C. Gulmann, R. Østerby, H. J. Bangstad, S. Rljdberg, M. Dempsey, S. Nathwani, M. P. Ryan, B. McMahon, C. Stenson, H. Murtagh, J. H. Brown, P. Doran, A. McGinty, M. A. Little, E. O’Brien, P. Owens, J. Holian, F. Mee, J. J. Walshe, S. A. Omer, D. Power, P. Diamond, R. W. Watson, A. Shahsafei, T. Jiang, B. M. Brenner, H. S. Mackenzie, J. Neary, A. Dorman, M. Keoghan, E. Campbell, J. Walshe, M. Little, L. Nee, C. O’Ceallaigh, H. McGlynn, E. Bergin, P. J. Garrett, T. Keane, G. Gormley, A. Watson, M. G. Atta, T. M. Perl, X. Song, E. Healy, M. Leonard, J. Lynch, A. J. Watson, D. Lappin, D. W. P. Lappin, K. Hannan, M. Burne, F. Daniels, H. Rabb, B. McBride, N. Kieran, C. Shortt, M. Codd, F. Murray, A. McCormack, C. Brown, C. Wong, A. M. Dorman, M. Keogan, J. Donohue, J. Farrell, J. Donohoe, S. O’Broin, A. Balfe, G. J. Mellotte, K. A. Abraham, C. McGorrian, A. E. Wood, M. Neligan, B. D. Kelly, P. Finnegan, M. Cormican, J. Callaghan, J. K. G. Crean, T. A. Moffitt, H. L. Devlin, A. Soosay, D. O’Neill, A. Counihan, D. Hickey, M. T. Keogan, K. Harvey, E. O’Riordan, S. Waldek, P. A. Kalra, D. J. O’Donoghue, R. N. Foley, A. O’Riordan, D. Kelliher, G. Mellotte, L. Giblin, J. A. B. Keogh, M. O’Connell, A. O’Meara, F. Breatnach, J. Gillick, H. Tazawa, P. Puri, E. Molloy, A. J. O’Neill, M. Sheridan-Pereira, J. M. Fitzpatrick, D. W. Webb, R. W. G. Watson, B. Linnane, C. O’Donnell, T. A. Clarke, C. Martin, M. McKay, J. McBrien, F. Glynn, C. O’Donovan, W. W. Hall, J. Smith, K. Khair, R. Liesner, I. M. Hann, O. P. Smith, S. Gallagher, M. J. Mahony, A. Hilal, J. F. Cosgrove, C. Monaghan, B. Craig, A. Al-Hassan, K. Walsh, D. Duff, P. O. Slizlok, C. Halahakoon, C. MacPherson, S. McMillan, E. E. Dalzell, J. McCaughan, A. O. B. Redmond, D. DeCaluwe, A. Yoneda, U. Akl, E. Dempsey, M. Farrell, D. Webb, A. Elabbas, G. Fox, S. Gormally, B. Grant, C. W. B. Corkey, A. Nicholson, A. Murphy, P. O’Grady, O. Barry, C. Macpherson, M. C. Stewart, F. Alderdice, T. G. Matthews, M. McDonnell, C. McGarvey, M. O’Regan, M. Ní Chróinín, P. Tormey, S. Ennis, A. J. Green, S. Abbas, A. O’Marcaigh, M. Conran, E. Crushell, A. Saidi, P. Curran, V. Donoghue, M. D. King, B. Elnazir, J. Leonard, C. Kavanagh, D. Brown, N. Corrigan, B. McCord, M. Quinn, L. O’Connell, B. Mcdonagh, A. Awan, D. Gill, R. Kakkar, D. G. Sweet, J. A. Warner, C. O’Connor, M. Herzig, A. Twomey, M. J. White, B. Sweeney, R. Surana, A. Hodgson, M. Rafferty, W. Livingstone, D. Peake, E. Wassemer, W. Whitehouse, N. Abdullah, P. Oslizlok, N. O’Connell, J. Balding, W. J. Livingstone, M. Healy, L. Mynett-Johnson, I. McAllister, A. C. Dick, B. Herron, V. E. Boston, C. O. Callaghan, D. O. Brien, A. Walsh, M. Philip, D. McShane, M. C. V. Hoey, F. Sharif, M. McDermott, M. Dillon, B. Drumm, M. Rowland, C. Imrie, S. Kelleher, B. Bourke, M. Iqbal, Y. Ziedan, M. O’Neill, S. O’Riordan, S. M. B. Basheer, S. O’Callaghan, A. Chong, M. Kelly, A. J. Nicholson, R. Cooke, C. Sreenan, M. Fallon, B. Denham, V. Dowding, G. Cussen, V. McManus, O. Hensey, H. Monaghan, S. N. Basheer, E. Quinn, H. M. C. V. Hoey, S. Mohamed, R. R. Ramesh, P. Mayne, E. Tracy, S. M. Gormally, E. Curtis, N. McCallion, R. Watson, O. O’Mahony, M. Keegan, K. Ward, D. Barton, J. Poulton, E. Treacy, J. Honour, D. deCaluwe, M. Ni Chróinín, J. Cosgrove, T. S. Chaudhry, N. M. Long, B. Lynch, P. Lasjaunais, D. G. M. McDonald, J. B. McMenamin, M. J. Farrell, E. F. Roche, A. Menon, C. Buckley, A. Mackey, K. Ohlandieck, A. Das, D. Reilly, O. Killeen, J. Harper, E. Roche, H. Hoey, J. Caird, D. O’Brien, D. Allcutt, N. Farrington, J. F. A. Murphy, J. M. Savage, A. J. Sands, F. A. Casey, B. G. Craig, J. C. Dornan, J. Johnston, C. Patterson, C. Lynch, H. C. Mulholland, D. C. Watkins, I. Young, G. Cran, C. A. G. Boreham, W. A. McCallion, N. F. Clements, M. R. Stevenson, D. O’Donoghue, L. Jenkins, A. J. Thompson, M. D. Shields, R. T. Taylor, R. Kerr, J. L. Hughes, M. Stewart, P. Jackson, C. Fitzpatrick, M. Rasheed, E. Colhoun, A. G. Bailie, S. Gray, S. Brown, A. Curley, K. J. MacMahon, C. M. O’Connor, A. Nichelson, N. E. Lynch, D. Finch, M. Foley, E. Scallan, B. Dillon, S. Lyons, R. O’Loughlin, M. Ward, R. Nally, A. Harkin, J. P. Kelly, B. E. Leonard, B. Nic Niocaill, P. Magee, T. J. Connor, Y. Shen, G. R. McCullough, S. M. McDonough, A. F. L. Cramp, M. Hynes, P. Corkery, M. Carey, D. McGarrigle, S. Higgins, H. Murray, C. J. Moran, M. C. Dennedy, J. Brosnan, L. Morris, B. L. Sheppard, A. Black, B. Wilkins, J. Folan-Curran, K. Skelton, M. Owens, C. Nemeroff, D. Houlihan, C. O’Keeffe, N. Nolan, P. A. McCormick, A. W. Baird, I. Raducan, P. Corcoran, R. Brennan, P. Molloy, A. Friel, M. Maher, M. Glennon, T. Smith, A. Nolan, J. A. Houghton, O. Carroll, S. Colleran, G. O’Cuinn, H. M. Snow, D. O’Regan, H. F. Markos, K. Pollock, D. M. Cannon, G. McBean, L. R. Quinlan, M. T. Kane, B. D. Higglns, D. M. Moriarty, D. Fitzgerald, A. Katkada, G. Canny, P. MacMathuna, M. M. O’Donovan, A. G. Schuur, K. J. Murphy, A. G. Foley, S. J. M. ten Bruggencate, and L. Ireland

Subjects
General Medicine
Published
2000
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24. Human parvovirus B19

Author

B Gilmer, H J O'Neill, D Igoe, and H Johnson

Subjects
Letter, Parvovirus, viruses, General Engineering, virus diseases, Outbreak, General Medicine, Human parvovirus, Biology, Blotting western, medicine.disease, biology.organism_classification, Rubella, Virology, Viral infection, Erythema Infectiosum, medicine, General Earth and Planetary Sciences, General Environmental Science
Abstract

EDITOR, - After investigating an outbreak in December 1993 of 24 cases of infection with parvovirus B19 in primary schools in Dublin, we wish to comment on J R Pattison's editorial.1 Firstly, Pattison noted that parvovirus B19 infection is often misdiagnosed as allergy, rubella, or other “viral infection” and may be clinically recognised only in an outbreak. The most striking feature reported …

Published
1994

25. Nelson's syndrome following partial pituitary microadenomectomy and pregnancy

Author

Pidgeon C, T. J. McKenna, D. Igoe, and Dinn J

Subjects
Adult, medicine.medical_specialty, Hypophysectomy, endocrine system diseases, Adenoma, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Pituitary neoplasm, Nelson Syndrome, Cushing syndrome, Endocrinology, Pregnancy, Internal medicine, medicine, Humans, Pituitary Neoplasms, Adenoma, Chromophobe, business.industry, Adrenalectomy, digestive, oral, and skin physiology, Nelson's syndrome, medicine.disease, Female, business, Tomography, X-Ray Computed, Pregnancy Complications, Neoplastic
Abstract

We report for the first time the development of Nelson's syndrome in a patient who had previously undergone unsuccessful pituitary microadenomectomy and subsequently bilateral adrenalectomy. The removal of a 3-mm portion of a microadenoma did not protect against the development of Nelson's syndrome within 3 years which was closely related to pregnancy, a previously noted association. This report suggests that the development of Nelson's syndrome depends not on the size of the initial pituitary tumour but rather on its individual potential for proliferating once free of the inhibitory effects of glucocorticoid excess.

Published
1992

26. The overnight dexamethasone test is a worthwhile screening procedure

Author

T. J. McKenna, Michael J. Duffy, D. Igoe, S K Cunningham, and C. Cronin

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Hydrocortisone, Endocrinology, Diabetes and Metabolism, Dexamethasone, Drug Administration Schedule, Cushing syndrome, Endocrinology, Internal medicine, Blood plasma, medicine, False positive paradox, Humans, Dexamethasone test, False Positive Reactions, Cushing Syndrome, business.industry, Incidence (epidemiology), Body Weight, Middle Aged, medicine.disease, Female, business, Glucocorticoid, medicine.drug
Abstract

The overnight low-dose dexamethasone test is a convenient screening procedure for Cushing's syndrome. Claims that the test is associated with a high incidence of 'false positives', rendering it of little value particularly in obese and hospital in-patients, have been investigated in the present study. The data from 100 consecutive subjects undergoing overnight low-dose dexamethasone tests to examine for the possibility of Cushing's syndrome, were reviewed. Cushing's syndrome was identified in four patients, normal suppression of cortisol values occurred in 84 patients and 12 patients exhibited false positive results. Differences in body weights, body mass indices or in-patient status did not distinguish between those subjects with normal suppression of plasma cortisol and those subjects who yielded false positive results. These data indicate that the simple overnight dexamethasone test substituted for the more cumbersome traditional 48-h dexamethasone test in 84 of 96 patients who did not have Cushing's syndrome. Thus the overnight test provides a useful screening procedure but a small percentage of patients, approximately 12.5%, will require additional procedures to exclude Cushing's syndrome.

Published
1990

27. Broncholithiasis: bronchoscopic vs. surgical management

Author

V. Lynch, D. Igoe, and Walter T. McNicholas

Subjects
Pulmonary and Respiratory Medicine, Adult, medicine.medical_specialty, business.industry, Radiography, Respiratory disease, Bronchial Diseases, Middle Aged, medicine.disease, Calculi, Text mining, Bronchoscopy, medicine, Humans, Female, Radiology, business
Published
1990

29. CONGENITAL DIAPHRAGMATIC HERNIA - PRENATAL DIAGNOSIS AND SURVIVAL

Author

Sixto García-Miñaur, E. Garne, D. Igoe, D. Lillis, M-C Addor, Paul Quataert, H. Mendizabal, C. De Vigan, and C. Moro-Bayon

Subjects
medicine.medical_specialty, business.industry, Pediatrics, Perinatology and Child Health, medicine, Congenital diaphragmatic hernia, Prenatal diagnosis, business, medicine.disease, Surgery
Published
1999
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31. Proceedings of the 13Th Annual Meeting of the Irish Endocrine Society

Author

Yvonne O'Connell, R. Beacom, J. Duffy, Alan H. Johnson, T. J. McKenna, D. R. McCance, M. P. S. Varma, K. Tipton, B. Sheridan, J. R. Hayes, S K Cunningham, D. B. Archer, T. K. Cooper, Daphne Owens, A. B. Atkinson, M. McGivern, J. A. McKnight, Wendy Jarema, D. Powell, J. R. Williams, Ronan M. Conroy, M. Cremin, Fidelma Dunne, L. Kennedy, M. Culliton, J. E. Gilmore, Hilary Leslie, S. C. Fitzpatrick, D. F. Smith, John Nelson, D. Murphy, B. McAleer, J. B. Ferriss, T. Moran, S. K. Cunningham, C. Cronin, B. J. Ruane, E. J. Burke, Patrick Collins, H. Whitehead, A. M. Hetherton, N. Corbally, D. R. Hadden, B. Byrne, Peter P.A. Smyth, G. Roberts, F. E. Corderoy, Mary McCabe, E. Turkington, Gerald H. Tomkin, Judith A. Allen, Ivan J. Perry, A. I. Traub, D. Igoe, Richard F. Murphy, and K. McElhinney

Subjects
medicine.medical_specialty, Irish, business.industry, Family medicine, language, Medicine, Endocrine system, General Medicine, business, language.human_language
Published
1989
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32. Royal Academy of Medicine in Ireland Section of Medicine

Author

B. Byrne, S. Cunningham, R. Conroy, T. J. McKenna, J. Cox, T. Cox, R. England, J. Walsh, D. Coakley, J. Feely, E. O’Brien, K. O’Malley, Fidelma P. M. Dunne, J. M. Gilvarry, F. Keeling, O. Fitzgerald, J. F. Fielding, D. Igoe, M. J. Duffy, M. J. Murphy, Conleth F. Feighery, C. P. Kelly, R. B. Gallagher, D. O’Neill, M. Rowan, D. Abraham, J. B. Walsh, and J. J. O’Sullivan

Subjects
General Medicine
Published
1989
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34. Ethanol-induced alterations in lecithin: cholesterol acyltransferase (LCAT) activity in vitro

Author

J J, Mulligan, J E, Cluette-Brown, F D, Igoe, R, Noring, T V, Osmolski, and J L, Hojnacki

Subjects
Phosphatidylcholine-Sterol O-Acyltransferase, Ethanol, Animals, Acetaldehyde, Cholesterol Esters, In Vitro Techniques, Saimiri
Abstract

Our recent experiments demonstrated that squirrel monkeys fed ethanol (ETOH) at 12% of calories (Low ETOH) had significantly higher plasma lecithin: cholesterol acyltransferase (LCAT) activity than monkeys fed ETOH at 24% of calories (High Ethanol). Control animals had LCAT activity intermediate between that of Low and High ETOH primates. To test whether alcohol directly altered cholesterol esterification in vitro, LCAT activity was measured in pooled primate plasma incubated with ETOH at final concentrations of 60, 80, 160, and 240 mg/dl. A similar experiment was performed using incremental doses of ETOH's major metabolite, acetaldehyde. Peak cholesterol esterification occurred at 60 mg/dl which was comparable to plasma alcohol levels detected in Low ETOH monkeys (63 mg/dl) while LCAT activity was significantly depressed at 160 mg/dl which was similar to blood ETOH monitored in High ETOH primates (159 mg/dl). Maximum cholesterol esterification occurred at an acetaldehyde concentration of 0.45 mumoles/l. Our data indicate that ETOH can either stimulate or inhibit LCAT activity in vitro depending upon concentration and suggest that circulating blood alcohol may induce similar alterations in cholesterol esterification in vivo.

Published
1986

35. Effect of ethanol on lecithin:cholesterol acyltransferase (LCAT) activity

Author

J J, Mulligan, J E, Cluette-Brown, R, Noring, F D, Igoe, J, Chong, and J L, Hojnacki

Subjects
Male, Phosphatidylcholine-Sterol O-Acyltransferase, Ethanol, Cholesterol, HDL, Animals, Lysophosphatidylcholines, Cholesterol Esters, Lipoproteins, HDL, Saimiri, Phospholipids
Abstract

The effect of variable doses of ethanol on plasma lecithin: cholesterol acyltransferase (LCAT) activity was examined in male, atherosclerosis-susceptible squirrel monkeys over a 12-month period. Primates were divided into three groups: 1) Controls fed isocaloric liquid diet; 2) Low Ethanol monkeys given liquid diet with vodka substituted isocalorically for carbohydrate at 12% of calories; and 3) High Ethanol animals fed diet plus vodka at 24% of calories. There were no significant differences between the treatments in serum glutamate oxaloacetate transaminase (SGOT), a measure of liver function. However, plasma LCAT activity (% esterification/min) measured in vitro was significantly reduced in High Ethanol monkeys while cholesterol esterification was elevated in the Low Ethanol group and intermediate in Controls. Similarly, the in vivo appearance of radiolabeled cholesteryl ester in high density lipoproteins (HDL) following the intravenous injection of 3H mevalonolactone was highest in the Low Ethanol primates, intermediate in Controls and significantly lower in monkeys fed the high alcohol diet. In vitro measurement of LCAT enzyme efficiency was similar for the three groups while substrate efficiency was lower in the High Ethanol treatment. Although LCAT activator (apoprotein A-I) was not markedly altered by dietary ethanol and the concentration of LCAT substrates (HDL free cholesterol and phosphatidyl choline) was significantly elevated in the High Ethanol group, subtle modifications in substrate-product composition may account for the observed reduction in cholesterol esterification. These include potential substrate and/or product LCAT inhibition resulting from increased concentrations of plasma free cholesterol, HDL lysophosphatidyl choline, and higher HDL2/HDL3 subfraction ratios, as well as alterations in HDL phospholipid fatty acid profiles in the High Ethanol group. Results from this study provide the first evidence of an anomalous enhancement in LCAT activity in nonhuman primates fed ethanol at 12% of calories and a marked depression in cholesterol esterification at the 24% dose which may be due to substrate alterations and product inhibition prior to overt biochemical evidence of liver dysfunction.

Published
1985

37. Royal academy of medicine in ireland

Author

T. O’Riordan, A. Shattock, S. Gardner, M. Hutchinson, P. Daly, S. Dinneen, C. Cronin, D. J. O’Sullivan, J. Fahy, G. O’Neill, J. O’Sullivan, V. Lynch, W. McNicholas, B. Maurer, M. X. FitzGerald, A. Green, M. Kinirons, Y. O’Meara, J. Donohoe, S. Murphy, M. Carmody, D. Igoe, C. Pidgeon, J. Dinn, T. J. McKenna, C. P. Kelly, C. F. Johnson, N. Nolan, P. W. N. Keeling, D. G. Weir, G. Mellotte, J. A. B. Keogh, and C. O’Morain

Subjects
General Medicine
Published
1989
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39. Continued circulation of mpox: an epidemiological and phylogenetic assessment, European Region, 2023 to 2024.

Author

Vaughan AM, Afzal M, Nannapaneni P, Leroy M, Andrianou X, Pires J, Funke S, Roman C, Reyes-Uruena J, Aberle S, Aristodimou A, Aspelund G, Bennet KF, Bormane A, Caraglia A, Charles H, Chazelle E, Christova I, Cohen O, Constantinou C, Couvreur S, Diaz A, Fabiánová K, Ferraro F, Grenersen MP, Grilc E, Hannila-Handelberg T, Hvass AK, Igoe D, Jansen K, Janță D, Kaoustou S, Koch A, Kosanovic Licina ML, Krumova S, Labutin A, Lachmann R, Lecompte A, Lefrançois R, Leitena V, Liitsola K, Mlinarić I, Mor Z, Neary M, Novacek A, Øgle MW, Orlíková H, Papadima K, Rehn M, Sadkowska-Todys M, Sîrbu A, Sondén K, Suárez B, Thordardottir M, Vasconcelos P, Vieira Martins J, Zakrzewska K, Widdowson MA, and Gossner CM

Subjects
Humans, Europe epidemiology, Male, Female, Adult, Middle Aged, Adolescent, Young Adult, Child, Aged, Population Surveillance, Child, Preschool, Incidence, Mpox (monkeypox), Phylogeny, Disease Outbreaks
Abstract

During the summer of 2023, the European Region experienced a limited resurgence of mpox cases following the substantial outbreak in 2022. This increase was characterised by asynchronous and bimodal increases, with countries experiencing peaks at different times. The demographic profile of cases during the resurgence was largely consistent with those reported previously. All available sequences from the European Region belonged to clade IIb. Sustained efforts are crucial to control and eventually eliminate mpox in the European Region.

Published
2024
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40. Mpox outbreak - Response and epidemiology of confirmed cases in Ireland from May 2022 to May 2023.

Author

Dillon C, O'Donnell K, McKeown P, Lyons F, Browne C, Fallon U, Keegan A, Timoney K, Bruton O, Downes P, Mullane P, Carroll C, Doyle S, Barrett P, Cosgrave B, Kieran R, Shanley A, Parlour R, Igoe D, and Robinson E

Subjects
Humans, Ireland epidemiology, Male, Female, COVID-19 epidemiology, Adult, Middle Aged, Adolescent, Child, Aged, Young Adult, Mpox (monkeypox), Disease Outbreaks
Abstract

Competing Interests: None declared.

Published
2024

41. The mitigating effect of street trees, urban flora, and the suburban environment on seasonal peak UV indices: A case study from Brisbane, Australia.

Author

Downs NJ, Amar A, Dearnaley J, Butler H, Dekeyser S, Igoe D, Parisi AV, Raj N, Deo R, and Turner J

Abstract

Tree shade, particularly shade that obscures direct sunlight near peak periods of midday solar exposure can have a pronounced effect on potentially harmful ultraviolet radiation, and in turn, strongly influence the maximum daily UV index (UVI). In this study, the seasonal influence of tree shade on the UVI is evaluated from 210 hemispherical sky view images collected alongside public walkways and footpaths from 10 residential Brisbane suburbs. The effective sidewalk UV index is calculated underneath planted tree canopies, adjacent residential gardens, buildings and background tree species. Results are presented with respect to seasonal variations in the diurnal solar elevation for each month of the year at Brisbane's latitude. The research also examines the total reduction in UVI due to the presence of individual tree species, showing reductions in the midday UVI of up to 91% of an equivalent unimpeded sky hemisphere when overhead tree canopies are present. Important footpath tree species for peak midday UVI mitigation include Pongamia pinnata, Xanthostemon chrysanthus, Senna siamea, and Libidibia ferrea. The planting and maintenance of existing tree species already growing alongside residential Brisbane streets will improve the shade characteristics of suburbs and enhance UV protection for local residents., (© 2024 The Author(s). Photochemistry and Photobiology published by Wiley Periodicals LLC on behalf of American Society for Photobiology.)

Published
2024
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42. Multiple introductions of monkeypox virus to Ireland during the international mpox outbreak, May 2022 to October 2023.

Author

Gonzalez G, Carr M, Kelleher TM, O'Byrne E, Banka W, Keogan B, Bennett C, Franzoni G, Keane P, Kenna C, Meredith LW, Fletcher N, Urtasun-Elizari JM, Dean J, Browne C, Lyons F, Crowley B, Igoe D, Robinson E, Martin G, Connell J, De Gascun CF, and Hare D

Subjects
Male, Humans, Adult, Female, Ireland epidemiology, Bayes Theorem, Disease Outbreaks, Monkeypox virus genetics, Mpox (monkeypox) diagnosis, Mpox (monkeypox) epidemiology
Abstract

BackgroundMpox, caused by monkeypox virus (MPXV), was considered a rare zoonotic disease before May 2022, when a global epidemic of cases in non-endemic countries led to the declaration of a Public Health Emergency of International Concern. Cases of mpox in Ireland, a country without previous mpox reports, could reflect extended local transmission or multiple epidemiological introductions.AimTo elucidate the origins and molecular characteristics of MPXV circulating in Ireland between May 2022 and October 2023.MethodsWhole genome sequencing of MPXV from 75% of all Irish mpox cases (182/242) was performed and compared to sequences retrieved from public databases (n = 3,362). Bayesian approaches were used to infer divergence time between sequences from different subclades and evaluate putative importation events from other countries.ResultsOf 242 detected mpox cases, 99% were males (median age: 35 years; range: 15-60). All 182 analysed genomes were assigned to Clade IIb and, presence of 12 distinguishable subclades suggests multiple introductions into Ireland. Estimation of time to divergence of subclades further supports the hypothesis for multiple importation events from numerous countries, indicative of extended and sustained international spread of mpox. Further analysis of sequences revealed that 92% of nucleotide mutations were from cytosine to thymine (or from guanine to adenine), leading to a high number of non-synonymous mutations across subclades; mutations associated with tecovirimat resistance were not observed.ConclusionWe provide insights into the international transmission dynamics supporting multiple introductions of MPXV into Ireland. Such information supported the implementation of evidence-informed public health control measures.

Published
2024
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43. Sharp increase in gonorrhoea notifications among young people, EU/EEA, July 2022 to June 2023.

Author

Nerlander L, Champezou L, Gomes Dias J, Aspelund G, Berlot L, Constantinou E, Díaz A, Epštein J, Fogarassy E, Hernando V, Hoffmann P, Igoe D, Klavs I, Pinto Leite P, Liitsola K, McIntyre A, Molnár Z, Olsen AO, Pires-Afonso Y, Putniņa R, Rudaitis K, Siakallis G, de Stoppelaar S, Suligoi B, Hannila-Handelberg T, Velicko I, Cabral Veríssimo V, Visser M, Wessman M, and Mårdh O

Subjects
Male, Humans, Female, Adolescent, Sexual Behavior, Heterosexuality, Gonorrhea epidemiology, Sexually Transmitted Diseases epidemiology
Abstract

Gonorrhoea cases increased steeply in women aged 20 to 24 years across 15 EU/EEA countries in July to December 2022 and January to June 2023 with, respectively, 73% and 89% more cases reported than expected, based on historical data from 2015 to 2019. Smaller increases among men due to heterosexual transmission were observed in nine EU/EEA countries. Interventions to raise awareness among young people about sexually transmitted infection risks are needed, emphasising the benefit of safe sexual practices and testing.

Published
2024
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44. XPS™ Jensen lung as a low-cost, high-fidelity training adjunct to ex-vivo lung perfusion.

Author

Gouchoe DA, Shukrallah B, Eggeman C, Igoe D, Ralston J, Mast D, Ganapathi AM, and Whitson BA

Subjects
Animals, Lung, Extracorporeal Circulation methods, Perfusion methods, Gases, Lung Transplantation methods
Abstract

Background: Ex vivo lung perfusion (EVLP) enables lung resuscitation before transplantation, and training is key, particularly in low-volume settings. To enable technique refinement and continuing education, we sought to demonstrate the value of a low-cost, high-fidelity EVLP simulator that would allow reproducible clinical scenarios., Methods: In partnership with our EVLP manufacturer, we utilized the XPS™ Jensen Lung with our clinical system. The Jensen Lung has two simulated lung bladders and an in-line polymethylpentene fiber oxygenator. It allows titration of ventilator support which aids in accurate clinical simulation. For simulations, blood gases (BGs) were obtained and compared with integrated in-line perfusate gas monitors (PGMs). PaO 2 , PCO 2 , and pH were measured and compared., Results: The PGM and BG values were not significantly different throughout the range of FiO 2 and sweep gas flow rates evaluated. The "delta" PaO 2 was measured between LA and PA and did not show any change between approaches. The pH measurement between BG and PGM was not significantly different., Conclusions: The XPS™ Jensen Lung simulator allows for a high-fidelity simulator of clinical EVLP. The correlation of the PGM and the BG measurement of the PaO 2 and pH allow for a low-cost simulation, as the PGMs are in line in the circuit, and enable real-time tracking of perfusate gas parameters with the PGM. Implementation of a standardized clinical EVLP training program allows the maintenance of technique and enables clinical simulation training without the need for costly animal perfusions and the use of multiple BG measurements., (© 2023 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC.)

Published
2023
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45. Optimizing the Seasonal Shade and Ultraviolet Protection of a Suburban Playground by Utilization of the Playground Shade Index.

Author

Downs N, Butler H, Parisi A, Beckman-Downs M, and Igoe D

Abstract

The Playground Shade Index (PSI) is introduced as a design metric for assessing the shade and solar ultraviolet (UV) protection provided by eight different cloth weave shade structures currently utilized in public playgrounds across a regional city located in southern Queensland, Australia. The PSI, expressing the ratio of available ambient solar UV exposure relative to the UV exposure received by a shaded 184 m 2 playground surface over a whole day in midsummer and midwinter, is used to determine the best design and aspect of all eight existing structures. Unlike subjective shade audits that may only consider the type of shade structure, the number and characteristics of surrounding trees, and surface materials available at a given site, the PSI considers, in addition to previous factors, the available sky fraction and the direct solar UV contribution underneath the shade structure over a full day. By considering the in situ UV protection characteristics of the shade structure, the PSI has demonstrated its value as a robust design metric. Of the eight shade structure styles examined, this research presents the most likely structure best suited for UV protection over the two solar UV extremes in summer and winter, including optimal structure aspect., (© 2023 American Society for Photobiology.)

Published
2023
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46. Hepatitis A and B vaccination in gbMSM in Ireland: findings from the European MSM Internet Survey 2017 (EMIS-2017).

Author

White P, O'Donnell K, Brennan A, Davoren M, Lyons F, Quinlan M, Foley B, Hurley C, Igoe D, and Barrett P

Subjects
Male, Humans, Homosexuality, Male, Ireland epidemiology, Surveys and Questionnaires, Vaccination, Hepatitis A epidemiology, Hepatitis A prevention & control, Sexual and Gender Minorities, Hepatitis A virus, HIV Infections epidemiology
Abstract

Objectives: Gay, bisexual and other men who have sex with men (gbMSM) have a higher risk of acquiring hepatitis A and B viruses (HAV and HBV) than the general population and are recommended for vaccination against both in Ireland. This study aims to determine the prevalence of self-reported HAV and HBV infection and vaccination among gbMSM in Ireland and explore factors associated with self-reported HAV and HBV vaccination among gbMSM., Methods: This study analysed Irish data from the European MSM Internet Survey 2017 (EMIS-2017) to measure the prevalence of self-reported HAV and HBV infection and vaccination among gbMSM in Ireland. Multivariable logistic regression was used to explore the associations between sociodemographic, healthcare-related and behavioural factors and self-reported vaccination., Results: There were 2083 EMIS-2017 respondents in Ireland. Among HIV-negative gbMSM, 4.6% and 4.4% reported previous HAV and HBV infection, respectively, and 51% and 57% reported the receipt of one or more vaccine dose for HAV and HBV, respectively. In the multivariable analysis, HIV-negative gbMSM had lower odds of self-reported HAV vaccination if they lived outside the capital, Dublin (aOR 0.61, 95% CI: 0.48 to 0.78), had no third-level education (aOR 0.65, 95% CI: 0.45 to 0.92), were not tested for HIV in the last year (aOR 0.39, 95% CI: 0.31 to 0.50), had never tried to obtain pre-exposure prophylaxis (PrEP, aOR 0.60, 95% CI: 0.38 to 0.96) and had not been diagnosed with a sexually transmitted infection (STI) in the previous year (aOR 0.42, 95% CI: 0.28 to 0.63). Similar associations were observed for self-reported HBV vaccination., Conclusions: Self-reported vaccination against HAV and HBV among gbMSM in Ireland is high, but the level of vaccination remains insufficient to protect against future HAV and HBV infections and outbreaks. Efforts to increase vaccination coverage among gbMSM should focus on men who live outside the capital, have lower educational attainment and do not engage with sexual health services., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2023
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47. Recreational and sexualised drug use among gay, bisexual, and other men who have sex with men (gbMSM) in Ireland-Findings from the European MSM internet survey (EMIS) 2017.

Author

Daly FP, O'Donnell K, Davoren MP, Noone C, Weatherburn P, Quinlan M, Foley B, Lyons F, Igoe D, and Barrett P

Subjects
Humans, Male, Homosexuality, Male, Ireland epidemiology, Cross-Sectional Studies, Sexual Behavior, Surveys and Questionnaires, Sexual and Gender Minorities, Substance-Related Disorders epidemiology, HIV Infections epidemiology
Abstract

Background: Gay, bisexual, and other men who have sex with men (gbMSM) report a higher prevalence of drug use in comparison to the general male population. However, in Ireland, there is a paucity of literature regarding the prevalence of drug use and its determinants among gbMSM., Aims/objectives: To quantify the prevalence of (i) recreational drug use (RDU) and (ii) sexualised drug use (SDU) among gbMSM in Ireland, and to identify the factors associated with these drug use practices., Methods: The European MSM Internet Survey (EMIS) 2017 was an online, anonymous, internationally-promoted questionnaire. Two binary outcomes were included in our analyses: (1) RDU and (2) SDU in the previous year. Multivariable-adjusted logistic regression explored factors associated with these outcomes, and all independent covariates were adjusted for one another., Results: Among gbMSM without HIV (n = 1,898), 40.9% and 13.1% engaged in RDU and SDU in the previous year, respectively. Among diagnosed-positive gbMSM (n = 141), the past-year respective prevalence estimates were 51.8% and 26.2%. Increased odds of RDU were observed among gbMSM who were younger (vs. 40+ years) (18-24 years; AOR 2.96, 95% CI 2.05-4.28, 25-39 years; AOR 1.66, 95% CI 1.27-2.16), lived in Dublin (vs. elsewhere) (AOR 1.47, 95% CI 1.17-1.83), and engaged in condomless anal intercourse (CAI) in the previous year (vs. none) (1-2 partners; AOR 1.79, 95% CI 1.34-2.38, 6+ partners; AOR 1.79, 95% CI 1.18-2.71). Greater odds of SDU were identified among those who lived in Dublin (vs. elsewhere) (AOR 1.50, 95% CI 1.07-2.10), and engaged in CAI (vs. none) (1-2 partners; AOR 3.16, 95% CI 2.05-4.88, 3-5 partners; AOR 2.50, 95% CI 1.47-4.26, and 6+ partners; AOR 3.79, 95% CI 2.23-6.43)., Conclusion: GbMSM report a high prevalence of drug use in Ireland. Targeted interventions, including harm reduction campaigns, may be needed to support healthier drug use choices among this community., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Daly et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Published
2023
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48. The Playground Shade Index: A New Design Metric for Measuring Shade and Seasonal Ultraviolet Protection Characteristics of Parks and Playgrounds.

Author

Downs N, Raj N, Vanos J, Parisi AV, Butler H, Deo R, Igoe D, Dexter B, Beckman-Downs M, Turner J, and Dekeyser S

Subjects
Play and Playthings, Seasons, Machine Learning, Humans, Child, Adult, Parks, Recreational, Ultraviolet Rays, Trees, Radiation Exposure prevention & control
Abstract

Current shading strategies used to protect outdoor playgrounds from harmful solar radiation include the placement of artificial cloth weaves or permanent roofing over a playground site, planting trees in proximity to playground equipment, and using vegetation or surface texture variations to cool playground surfaces. How and where an artificial shade structure is placed or a tree is planted to maximize the shade protection over specific playground areas, requires careful assessment of local seasonal sun exposure patterns. The Playground Shade Index (PSI) is introduced here as a design metric to enable shade and solar ultraviolet exposure patterns to be derived in an outdoor space using conventional aerial views of suburban park maps. The implementation of the PSI is demonstrated by incorporating a machine learning design tool to classify the position of trees from an aerial image, thus enabling the mapping of seasonal shade and ultraviolet exposure patterns within an existing 7180 m 2 parkland. This is achieved by modeling the relative position of the sun with respect to nearby buildings, shade structures, and the identified evergreen and deciduous tree species surrounding an outdoor playground., (© 2022 American Society for Photobiology.)

Published
2023
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49. A large multi-country outbreak of monkeypox across 41 countries in the WHO European Region, 7 March to 23 August 2022.

Author

Vaughan AM, Cenciarelli O, Colombe S, Alves de Sousa L, Fischer N, Gossner CM, Pires J, Scardina G, Aspelund G, Avercenko M, Bengtsson S, Blomquist P, Caraglia A, Chazelle E, Cohen O, Diaz A, Dillon C, Dontsenko I, Kotkavaara K, Fafangel M, Ferraro F, Firth R, Fonager J, Frank C, Carrasco MG, Gkolfinopoulou K, Grenersen MP, Guzmán Herrador BR, Henczkó J, Hoornenborg E, Igoe D, Ilić M, Jansen K, Janță DG, Johansen TB, Kasradze A, Koch A, Kyncl J, Martins JV, McAuley A, Mellou K, Molnár Z, Mor Z, Mossong J, Novacek A, Orlikova H, Pem Novosel I, Rossi MK, Sadkowska-Todys M, Sawyer C, Schmid D, Sîrbu A, Sondén K, Tarantola A, Tavares M, Thordardottir M, Učakar V, Van Ewijk C, Varjas J, Vergison A, Vivancos R, Zakrzewska K, Pebody R, and Haussig JM

Subjects
Animals, Child, Disease Outbreaks, Female, Humans, Monkeypox virus, World Health Organization, Exanthema, Mpox (monkeypox) diagnosis, Mpox (monkeypox) epidemiology
Abstract

Following the report of a non-travel-associated cluster of monkeypox cases by the United Kingdom in May 2022, 41 countries across the WHO European Region have reported 21,098 cases and two deaths by 23 August 2022. Nowcasting suggests a plateauing in case notifications. Most cases (97%) are MSM, with atypical rash-illness presentation. Spread is mainly through close contact during sexual activities. Few cases are reported among women and children. Targeted interventions of at-risk groups are needed to stop further transmission.

Published
2022
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50. The Study to Investigate COVID-19 Infection in People Living in Ireland (SCOPI): A seroprevalence study, June to July 2020.

Author

Heavey L, Garvey P, Colgan AM, Thornton L, Connell J, Roux T, Hunt M, O'Callaghan F, Culkin F, Keogan M, O'Connor N, O'Sullivan MB, O'Sullivan S, Tait M, De Gascun CF, and Igoe D

Subjects
Antibodies, Viral, Cross-Sectional Studies, Humans, Ireland epidemiology, SARS-CoV-2, Seroepidemiologic Studies, COVID-19
Abstract

BackgroundRobust data on SARS-CoV-2 population seroprevalence supplement surveillance data in providing evidence for public health action.AimTo conduct a SARS-CoV-2 population-based seroprevalence survey in Ireland.MethodsUsing a cross-sectional study design, we selected population samples from individuals aged 12-69 years in counties Dublin and Sligo using the Health Service Executive Primary Care Reimbursement Service database as a sampling frame. Samples were selected with probability proportional to the general population age-sex distribution, and by simple random sampling within age-sex strata. Antibodies to SARS-CoV-2 were detected using the Abbott Architect SARS-CoV-2 IgG Assay and confirmed using the Wantai Assay. We estimated the population SARS-CoV-2 seroprevalence weighted for age, sex and geographic area.ResultsParticipation rates were 30% (913/3,043) and 44% (820/1,863) in Dublin and Sligo. Thirty-three specimens had detectable SARS-CoV-2 antibodies (1.9%). We estimated weighted seroprevalences of 3.12% (95% confidence interval (CI): 2.05-4.53) and 0.58% (95% CI: 0.18-1.38) for Dublin and Sligo, and 1.69% (95% CI: 1.13-2.41) nationally. This equates to an estimated 59,482 (95% CI: 39,772-85,176) people aged 12-69 years nationally having had infection with SARS-CoV-2, 3.0 (95% CI: 2.0-4.3) times higher than confirmed notifications. Ten participants reported a previous laboratory-confirmed SARS-CoV-2 -infection; eight of these were antibody-positive. Twenty-five antibody-positive participants had not reported previous laboratory-confirmed infection.ConclusionThe majority of people in Ireland are unlikely to have been infected with SARS-CoV-2 by June-July 2020. Non-pharmaceutical public health measures remained key pending widespread availability of vaccination, and effective treatments.

Published
2021
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