26 results on '"D. Gounder"'
Search Results
2. High Momentum Jet Flames at Elevated Pressure, E: Quantification of droplet size distribution and transport
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Holger Ax, James D. Gounder, Rainer Lükerath, Fabian Hampp, Matthias Hase, Bertram Janus, and Oliver Lammel
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Physics::Fluid Dynamics ,Stress (mechanics) ,Jet (fluid) ,Momentum (technical analysis) ,pressure ,Materials science ,high momentum jet ,droplet size ,Mechanics ,Combustion ,High momentum ,Droplet size - Abstract
The present work investigates a model combustor that approximates a full-scale segment of a high momentum jet stabilised combustion concept with the objective to broaden fuel flexibility limits. The rig features optical access for detailed laser based diagnostics. The current experiments are conducted at a pressure of 8 bar, constant jet velocity and adiabatic flame temperature. Three different injection systems are used to inject oil and oil / water blends. Droplet size distributions and turbulent droplet transport are quantified by means of phase Doppler interferometry. The injection system has a noticeable impact on the droplet size distribution. Water addition affects the fuel placement in radial direction significantly with distinct droplet transport into the reaction zone. The jet core and droplet transport is maintained as far as 7 x/d axial downstream from the nozzle exit. The shear layer shows a turbulent intensity of 12% of the main jet bulk velocity that drives the radial droplet transport into the recirculation zone. Mass flow and number density estimations illustrate the spatial distribution of the liquid loading in the combustion chamber. The present findings are complementary to the work in part A–D, support the development of fuel and load flexible high momentum jets based combustion concepts and the development and validation of numerical models.
- Published
- 2020
3. High Momentum Jet Flames at Elevated Pressure: Part D — Simultaneous Measurements of OH/PAH PLIF and Mie Scattering on Liquid Fuels
- Author
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Oliver Lammel, Rainer Lückerath, Manfred Aigner, Holger Ax, James D. Gounder, and Dominik Schäfer
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Momentum ,Gas turbines ,Jet (fluid) ,Materials science ,Mie scattering ,Scattering radiation ,Analytical chemistry ,Combustion ,High momentum - Abstract
A promising alternative to modern swirl combustors for gas turbines are high momentum jet stabilized combustors. This gas turbine burner concept consists of circular arranged jet nozzles through which partially premixed high momentum jets enter the combustion chamber in axial direction. Furthermore, it features fuel flexibility, load flexibility and low pollutant emissions. The investigated generic combustor consists of an eccentric single nozzle in a square chamber. This nozzle represents a full-scale segment of a concentrically arranged multi-nozzle configuration. All measurements were carried out at the high pressure combustion test rig (HBK-S) at the German Aerospace Center (DLR) in Stuttgart. The generic single nozzle model combustor has been operated in a high-pressure test rig with large optical access in order to gain a detailed understanding of fuel distribution, droplet distribution, fuel air mixing and high temperature regions through various sections of the combustion chamber. For this purpose, different laser based measurement techniques have been applied simultaneously under gas turbine relevant conditions on liquid fuels (oil and oil/water). Other measurements in this combustor on gaseous fuels were presented in preceding (parts A and B) and current publications (part C). Mie scattering was used to visualize the liquid phase of oil and water downstream of the nozzle. In order to gain knowledge about the droplet velocity, a Nd:YAG double pulse laser at 532 nm was used for Particle Image Velocimetry (PIV). Additionally the gaseous and liquid phases of oil have been visualized through Planar Laser Induced Fluorescence (PLIF) by excitation of poly-cyclic aromatic hydrocarbons (PAHs) with a laser wavelength of 266 nm. To observe high temperature regions, OH and PAH PLIF was also performed with a low bandwidth at 283 nm from a Nd:YAG pumped dye laser. It was possible to separate the low-intensity OH signal of the hot gas regions from the PAH signal by collecting the different LIF signals simultaneously through a dual camera setup. Instantaneous PAH LIF images of the liquid and gaseous phase were compared with Mie scattering images for a qualitative impression of the evaporation. For this a structural comparison between the liquid phases of both images has been carried out. Results indicate, that the evaporation of most of the liquid fuel takes place near the hot gas region, as a large proportion of droplets are carried far downstream of the nozzle by the high momentum jet.
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- 2019
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4. Exhaust Gas Recirculation at Elevated Pressure Using a FLOX® Combustor
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Clemens Naumann, Peter Kutne, James D. Gounder, Wolfgang Meier, and Judith Richter
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gas turbine ,Momentum (technical analysis) ,Power station ,business.industry ,Nuclear engineering ,optical diagnostics ,Exhaust gas recirculation ,Flox ,Combustion ,law.invention ,Ignition system ,pressure ,law ,FLOX ,Combustor ,Environmental science ,Combustion chamber ,business ,combustion kinetics - Abstract
To reduce CO2 emissions from the combustion of fossil and alternative fuels, carbon capture technologies present a promising approach. But the efficiency of the capture process depends on the CO2 concentration in the exhaust gas which is relatively low for gas turbine power plants. Exhaust gas recirculation (EGR) is a promising approach to increase the CO2 concentration in the exhaust gas stream and thus reduce the energy losses. In this study a FLOX® combustor was used to investigate the influence of EGR on the combustion process of natural gas at elevated pressure. The combustor stabilizes the flame without use of swirl, by creating a strong recirculation through high momentum injection of the fresh gas into the combustion chamber. This enables the establishment of a distributed combustion zone, which promises advantages for the use of gas mixtures with low reactivity like those occurring in EGR processes. At a pressure of 5 bar it was possible to increase the CO2 concentration in the exhaust gas up to 7 vol%, which is already enough to realize an efficient CO2 capture process. At 10 bar the CO2 concentration could be increased to 9 vol%. The changes in flame stabilization due to pressure increase and different EGR rates are investigated by OH*-chemiluminescence imaging and discussed. The contribution of auto-ignition and flame propagation to flame stabilization is estimated by a kinetic model calculation.
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- 2017
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5. Experimental Investigation of a Bluff Body Burner for Distributed Hydrogen Injection
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Peter Kutne, Andrea Gruber, and James D. Gounder
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Gas turbines ,Materials science ,Hydrogen ,Analytical chemistry ,chemistry.chemical_element ,Vortex ,law.invention ,chemistry ,law ,Bluff ,Combustor ,Hydrogen fuel enhancement ,Luminescence ,Chemiluminescence - Abstract
A novel concept for injection of gaseous hydrogen (fuel) into a stream of air (oxidant) with in low-NOx gas turbine combustion systems is proposed and tested experimentally in a laboratory bluff body (BB) burner. Instead of conventional injection nozzles, that represent undesired point sources of the highly reactive fuel, the injection concept presented in this paper employs porous steel components, with anticipation to achieve hydrogen injection into air in a compositionally diluted and spatially distributed fashion. The BB burner is tested with four different bluff bodies: three bluff bodies manufactured of solid steel and characterized by different diameters are used to chart the burner behavior in conventional, fully-premixed operation with respect to flame stoichiometry and bulk velocity; one bluff body of porous steel is used to implement and demonstrate the distributed fuel injection (BB-DFI) concept. The experimental setup consists of OH* chemiluminescence (CL) and luminescence of flame measured at kHz repetition rate (4 kHz OH* CL and 14 kHz luminescence of flame) using high-speed cameras. Stable operation of the BB-DFI burner configuration with distributed hydrogen injection is demonstrated in the equivalence ratio range of 0.3–0.5 for three bulk velocities of 15, 25 and 35 m/s with the flame anchoring downstream of the distributed injection section, on the tip of the bluff body, according to design. The flame shape observed during the initial tests suggests inadequate mixing between the fuel and carrier air in the mixing section. For comparison, three different arrangements of vortex generators are designed and manufactured to improve fuel-oxidant mixing. The effectiveness of the vortex generators in terms of mixing is investigated using laser induced fluorescence (LIF) technique and one of the vortex generator arrangement show promising improvement in fuel-oxidant mixing.
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- 2017
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6. The use of the electronic (computer) cross-match
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Michael F. Murphy, K.G. Davis, Ck K. Lin, Jørgen Georgsen, Hw W. Reesink, E. Raspollini, Paolo Rebulla, J. Safwenberg, W. R. Mayr, Dv V. Devine, Dw W. M. Schwartz, F. Roubinet, Jacques Chiaroni, Tc C. Mercado, V. Ferrera, Oc C. Illoh, Julie Staves, B. O'Donovan, C. Milkins, Janet Yuen Ha Wong, D. Gounder, Jm M. Fitzgerald, S. Makino, Simon Panzer, and S. Villa
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medicine.medical_specialty ,Multimedia ,business.industry ,Hematology ,General Medicine ,computer.software_genre ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Family medicine ,Medicine ,030212 general & internal medicine ,Electronic computer ,business ,computer - Published
- 2013
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7. The New Zealand rare donor program
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D, Gounder
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Blood Group Antigens ,Blood Banks ,Humans ,Blood Donors ,Blood Transfusion ,New Zealand - Published
- 2016
8. Experimental and numerical investigation of spray characteristics in a new FLOX® based combustor for liquid fuels for Micro Gas Turbine Range Extender (MGT-REX)
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Anton Zizin, Oliver Lammel, Sagar R. Kulkarni, James D. Gounder, Manfred Aigner, and Michael Rachner
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Spray characteristics ,micro gas turbine ,Materials science ,Micro gas turbine ,020209 energy ,Nuclear engineering ,Extender ,02 engineering and technology ,law.invention ,020303 mechanical engineering & transports ,0203 mechanical engineering ,spray ,law ,Range (aeronautics) ,FLOX ,0202 electrical engineering, electronic engineering, information engineering ,Combustor ,flox ,Composite material ,Verbrennungsdiagnostik ,Computersimulation - Published
- 2016
9. Spray Characteristics Measured in a New FLOX Based Low Emission Combustor for Liquid Fuels Using Laser and Optical Diagnostics
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Manfred Aigner, Anton Zizin, Oliver Lammel, and James D. Gounder
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Spray characteristics ,Materials science ,business.industry ,Nozzle ,Evaporation ,Analytical chemistry ,Flox ,Laser ,law.invention ,law ,Low emission ,laser diagnostics ,FLOX ,Combustor ,Optoelectronics ,Combustion chamber ,business - Abstract
A liquid fuel combustor based on the FLOX® burner concept has been developed for application in a Micro Gas Turbine (MGT) Range Extender (REX) for next generation cars. The characterization of this combustor was performed at the High Pressure Optical Test rig (HIPOT) at DLR Stuttgart. The operability limits of the burner were mapped out for full load conditions at 3.5 bars by varying global lambda (λG) from 1.25–2.00 and bulk jet velocity (vBulk) from 80–140 m/s. Exhaust gas measurements show NOx and CO levels below 5 and 10 ppm respectively (corrected for reference 15% O2) at λG = 1.89. Optical and laser diagnostic measurement techniques have been employed to characterize the spray flames. The flames at stable burner operation points (BOPs) show a predominantly jet like flame shape irrespective of λG and vBulk. Droplets in the size range 2–40 μm have been measured close to the nozzle exit plane. Velocities conditioned on the droplet size show large droplets d > 15 μm transitioning from negative slip velocity at the exit plane to positive slip velocity at downstream location. The positive slip velocities and slow evaporation of large droplets lead to droplets travelling further into the combustion chamber and hence resulting in long flames. A comprehensive data set for the spray characteristic of the new liquid FLOX® burner is made available.
- Published
- 2016
10. Quality controls of cryopreserved haematopoietic progenitor cells (peripheral blood, cord blood, bone marrow)
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Gerrit Jan Schuurhuis, Mike Halpenny, D. Gounder, M. Grommé, Halvard Bonig, Minoko Takanashi, Elaine Forrest, I. Van Riet, SJ Ragg, Eric Braakman, Markus Wiesneth, Mindy Goldman, Nina Worel, Rita Fontão-Wendel, George Galea, P. Accorsi, Jess Oh, Rachel Pawson, Konrad Rosskopf, Peter Schauwecker, Hubert Schrezenmeier, T. Bonfini, Anthony Giulivi, Andreas Humpe, Erhard Seifried, Jo Anna Reems, Ute Buwitt-Beckmann, Angela Brand, A. Wong, Reinhard Henschler, Jon Smythe, Matti Korhonen, R. Dooccey, Frank Preijers, Henk W. Reesink, Simon Panzer, Anne Arvola, Brenda Letcher, Locksley Mcgann, Arlete Lazar, J. M. van Beckhoven, and Silvano Wendel
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Oncology ,medicine.medical_specialty ,business.industry ,Hematology ,General Medicine ,Cryopreservation ,Transplantation ,Cell therapy ,Haematopoiesis ,medicine.anatomical_structure ,Cord blood ,Internal medicine ,medicine ,Bone marrow ,Progenitor cell ,Stem cell ,business - Abstract
The final quality control of cryopreserved progenitor cells is a successful and persistent three lineage engraftment after transplantation. Of course, the stem cell providing institution is obliged to have a program for controlling and monitoring the manufacturing of cellular therapy products before the patients’ conditioning therapy is started. The FACT-JACIE Standards [1] and the Netcord ⁄ FACT Stan- dards prescribe that the director of the institute shall define tests and procedures for measuring and assaying cellular therapy products to ensure their safety, viability and integ- rity and shall also ensure that products meet predetermined release specifications. This requires specifications of assays and the definition of thresholds to allow release.
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- 2011
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11. Donors with a rare pheno (geno) type
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D. Gounder, M. A. de Brito, K. Barotine-Toth, C. C. Folman, S. Wendel, J. Matilainen, Vered Yahalom, H. Hustinx, Pertti Sistonen, M. de Haas, Orna Asher, Geralyn M. Meny, Maria Antonietta Villa, P.Y. Le Pennec, Rita Fontão-Wendel, Harald Schennach, S. R. Joshi, W. C. Tsoi, K. Vasantha, I. von Zabern, Peter Flanagan, M. M. W. Koopman, C. P. Engelfriet, Maurizio Marconi, Christoph Niederhauser, Erik A M Beckers, I. Hoffer, C. K. Lin, Nicoletta Revelli, N. Greppi, Cyril Levene, Christoph Gassner, E. Aranburu Urtasun, Lorna Wall, Henk W. Reesink, Philippe Rouger, Willy A. Flegel, Bach-Nga Pham, Sandra Nance, Yoshihiko Tani, T. Peyrard, C. Flickinger, Gastroenterology and Hepatology, Other departments, and Landsteiner Laboratory
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Male ,Isoantigens ,Genotype ,business.industry ,Blood Donors ,Hematology ,General Medicine ,Phenotype ,Blood group antigens ,Isoantibodies ,Immunology ,Blood Group Antigens ,Humans ,Medicine ,Female ,business - Published
- 2008
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12. Phase Resolved Analysis of Flame Structure in Lean Premixed Swirl Flames of a Fuel Staged Gas Turbine Model Combustor
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Stefan Wysocki, Isaac Boxx, Fernando Biagioli, James D. Gounder, and Peter Kutne
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Premixed flame ,flame structure ,Swirl ,Atmospheric pressure ,Chemistry ,General Chemical Engineering ,Flame structure ,General Physics and Astronomy ,Energy Engineering and Power Technology ,Thermal power station ,General Chemistry ,Mechanics ,optical diagnostic ,premix ,Fuel Technology ,Thermoacoustics ,Flow velocity ,Extinction (optical mineralogy) ,Gas turbine ,Combustor ,Verbrennungsdiagnostik ,Staged combustion ,fuel staging - Abstract
A scaled model of a gas turbine (GT) burner with coaxially mounted swirlers has been used to study the effects of fuel staging on the behavior of lean premixed methane air flames. Lean flames are known to be susceptible to instabilities that can lead to unsteady operation, flame extinction, and thermo-acoustic oscillations. High speed (10 kHz) laser and optical diagnostic techniques have been used to investigate the fuel staging effect on the mechanisms involved in such instabilities. Methane air flames at atmospheric pressure have been investigated at a constant thermal power of 58 kW. The global equivalence ratio was kept constant, while the fuel staging was varied. The bulk flow velocity at the exit plane was kept constant at 20 m/s. Simultaneous high speed OH PLIF, OH* CL, and acoustic measurements were performed at kHz repetition rate to characterize the flames and determine the operability limits of the combustor. The characterization measurements reveal significant changes in flame shape for variou...
- Published
- 2014
13. An Investigation of the Effects of Fuel Staging on Flame Structure in a Gas Turbine Model Combustor
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James D. Gounder, Peter Kutne, Fernando Biagioli, Isaac Boxx, and Holger Luebcke
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gas turbine ,Gas turbines ,flame structure ,Materials science ,business.industry ,Nuclear engineering ,Flame structure ,Particulates ,Methane ,chemistry.chemical_compound ,chemistry ,Combustor ,Combustion chamber ,business ,Nitrogen oxides ,fuel staging ,Thermal energy - Abstract
Gas turbine (GT) flames at lean operating conditions are susceptible to instabilities that can lead to unsteady operation, flame extinction, and thermoacoustic oscillations. High speed (10 kHz) laser and optical diagnostic techniques have been used to investigate the effect of fuel staging on the mechanisms involved in such instabilities and the overall performance of a gas turbine model combustor. The GT burner used in this study consists of coaxial swirlers which allow for fuel staging capability, where the fuel is varied from 100% to 20% fuel injection in the inner swirler. The burner is equipped with a combustion chamber with large quartz windows, allowing for the application of optical and laser diagnostics. Simultaneous high speed OH Planar Laser Induced Fluorescence (PLIF) and OH* chemiluminescence (CL) imaging, exhaust gas sampling and acoustic measurements were applied to characterize the flames and determine the operability limits of the combustor. Methane air flames at atmospheric pressure have been investigated at a constant thermal power of 58 kW. The global equivalence ratio was kept constant, while the fuel staging was varied. The bulk flow velocity at the exit plane was kept constant at 20 m/s. Simultaneous high speed particle image velocity (PIV) and OH PLIF measurements were performed at a repetition rate of 10 kHz on specifically chosen flames with a fixed staging and equivalence ratio. This paper will present the flame and the flow field structure resolved using the kHz measurement technique. The interaction between the velocity field and the flame front marked by the OH LIF will be presented. The mean PIV image provides the location of the inner and outer recirculation zones. The flame structure presented in this paper will also show the effectiveness of fuel mixing as the staging is varied. The changes in flame shape with variation in fuel staging is determined using the OH* chemiluminescence images. As the fuel flow in the inner swirler is reduced, the NOx and CO emissions also reduce and reach a minimum at a staging of 45% fuel being injected in the inner swirler. As fuel injection in the outer swirler increases beyond 60% the NOx and CO emissions start also increasing.
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- 2013
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14. Flame Stabilization and Auto-Ignition of Pulsed Methane Jets in a Hot Coflow: Influence of Temperature
- Author
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James D. Gounder, Robert Schießl, Manfred Aigner, Christoph M. Arndt, and Wolfgang Meier
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Jet (fluid) ,Hydrogen ,Chemistry ,Mechanical Engineering ,General Chemical Engineering ,methane ,Analytical chemistry ,Exhaust gas ,chemistry.chemical_element ,Laminar flow ,Atmospheric temperature range ,Molecular physics ,Methane ,law.invention ,Ignition system ,chemistry.chemical_compound ,kHz Laser diagnostics ,Physics::Plasma Physics ,law ,Physics::Chemical Physics ,Physical and Theoretical Chemistry ,Coaxial ,Verbrennungsdiagnostik ,auto ignition - Abstract
The auto-ignition of a pulsed methane jet issuing into a coaxial laminar coflow of hot exhaust gas from a lean premixed hydrogen/air flat flame has been studied experimentally by means of high-speed optical diagnostics. The downstream location of the first auto-ignition kernel as well as the stabilization height of the steady-state lifted jet flame and the auto-ignition time were determined by OH ∗ chemiluminescence (CL) measurements. OH planar laser-induced fluorescence (PLIF) was used to determine further details of the auto-ignition with a higher spatial resolution and increased sensitivity. In order to three-dimensionally reconstruct the ignition kernel location in space and only include ignition kernels in the PLIF processing that first occurred inside the laser light sheet, broadband luminosity imaging from a viewing angle perpendicular to the PLIF and CL measurements was performed. The coflow temperature was varied in the temperature range between 1566 and 1810 K in order to study the influence of the coflow temperature on the auto-ignition height, auto-ignition time, and on the lift-off height of the steady lifted jet flame. In addition, detailed model simulations were performed to study the influence of temperature and strain on auto-ignition in reacting mixing layers.
- Published
- 2013
15. Auto-Ignition and Flame Stabilization of Pulsed Methane Jets in a Hot Vitiated Coflow Studied with High-Speed Laser and Imaging Techniques
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James D. Gounder, Manfred Aigner, Wolfgang Meier, and Christoph M. Arndt
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Premixed flame ,Jet (fluid) ,Materials science ,Physics and Astronomy (miscellaneous) ,Hydrogen ,business.industry ,flame stabilization ,General Engineering ,auto-ignition ,General Physics and Astronomy ,chemistry.chemical_element ,imaging ,Laminar flow ,kHz laser ,Viewing angle ,Laser ,Schlieren imaging ,law.invention ,Ignition system ,Optics ,chemistry ,law ,Physics::Chemical Physics ,business ,Verbrennungsdiagnostik - Abstract
The auto-ignition of a pulsed methane jet issuing into a laminar coflow of hot exhaust products of a lean premixed hydrogen/air flat flame was examined using high-speed laser and optical measurement techniques with frame rates of 5 kHz or more. OH* chemiluminescence was used to determine the downstream location of the first auto-ignition kernel as well as the stabilization height of the steady-state lifted jet flame. OH planar laser-induced fluorescence (PLIF) was used to determine further details of the auto-ignition with a higher spatial resolution. Simultaneous imaging of broadband luminosity from a viewing angle perpendicular to the OH* chemiluminescence was applied, to three-dimensionally reconstruct the ignition kernel location in space and to determine whether the first occurrence of the kernel was within or beyond the PLIF laser sheet. The development and expansion of the jet was characterized by high-speed Schlieren imaging. Statistics have been compiled for both the ignition time as well as the downstream location of the first auto-ignition kernel and the stabilization height of the steady-state lifted jet flame. From the PLIF images it was found that auto-ignition tended to occur at the interface between bulges of the inflowing jet and the coflow. For steady-state conditions, auto-ignition kernels were observed frequently below the flame base, emphasizing that the lifted jet flame is stabilized by auto-ignition.
- Published
- 2012
16. Quality controls of cryopreserved haematopoietic progenitor cells (peripheral blood, cord blood, bone marrow)
- Author
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K, Rosskopf, S J, Ragg, N, Worel, M, Grommé, F W M B, Preijers, E, Braakman, G J, Schuurhuis, I, van Riet, S, Wendel, R, Fontão-Wendel, A, Lazar, M, Goldman, M, Halpenny, A, Giulivi, B, Letcher, L, McGann, M, Korhonen, A, Arvola, A, Humpe, U, Buwitt-Beckmann, M, Wiesneth, P, Schauwecker, H, Schrezenmeier, H, Bönig, R, Henschler, E, Seifried, P, Accorsi, T, Bonfini, M, Takanashi, J M, van Beckhoven, A, Brand, D, Gounder, A, Wong, R, Dooccey, E, Forrest, G, Galea, J, Smythe, R, Pawson, J-A, Reems, J, Oh, H W, Reesink, S, Panzer, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Genetica & Celbiologie, Interne Geneeskunde, Hematology laboratory, CCA - Innovative therapy, Gastroenterology and Hepatology, and Hematology
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Cryopreservation ,Male ,Quality Control ,Immune Regulation Translational research [NCMLS 2] ,Translational research [ONCOL 3] ,Hematopoietic Stem Cell Transplantation ,Humans ,Transplantation, Homologous ,Female ,Hematopoietic Stem Cells ,Total Quality Management - Abstract
Item does not contain fulltext 01 oktober 2011
- Published
- 2011
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17. Combustion behaviour of swirl stabilised oxyfuel flames at elevated pressure
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Bhavin K. Kapadia, James D. Gounder, Peter Kutne, and Wolfgang Meier
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pressure ,Materials science ,optical diagnostics ,swirl flames ,Metallurgy ,Combustion ,oxyfuel combustion - Published
- 2011
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18. Monitoring and treatment of anti-D in pregnancy
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S. Villa, Frank P.H.A. Vandenbussche, Ulrik Sprogøe, H. H. H. Kanhai, D. Gounder, B. Csapo, C. Pessoa, W. Stein, C. Sefonte, Simon Panzer, Ansa Aitokallio-Tallberg, D. Bettelheim, Tobias J. Legler, Svein Magne Skulstad, Malla Kuosmanen, Peter Flanagan, S. Koskinen, Maria Antonietta Villa, F. Guerra, L. Trespidi, Emma Parry, B. Zupanska, Olav Lapaire, Xiao Yan Zhong, Morten Hanefeld Dziegiel, Wolfgang Holzgreve, Tor Hervig, M. de Haas, Małgorzata Uhrynowska, B. Acaia, Henk W. Reesink, S. Wendel, Anneke Brand, R. Donegan, Pavel Calda, O Flesland, Gastroenterology and Hepatology, and Landsteiner Laboratory
- Subjects
medicine.medical_specialty ,Pediatrics ,Rho(D) Immune Globulin ,030204 cardiovascular system & hematology ,Rh Isoimmunization ,Blood group antigens ,03 medical and health sciences ,0302 clinical medicine ,Isoantibodies ,Pregnancy ,Medicine ,Humans ,Intensive care medicine ,Fetal Hemoglobin ,030219 obstetrics & reproductive medicine ,Rh-Hr Blood-Group System ,Cardiovascular diseases [NCEBP 14] ,business.industry ,Incidence (epidemiology) ,Public health ,Pregnancy Complications, Hematologic ,Hematology ,General Medicine ,medicine.disease ,Fetal Blood ,3. Good health ,Immunization ,Blood Group Antigens ,Treatment strategy ,Female ,business ,Haemolytic disease - Abstract
Prophylactic anti-D is a very safe and effective therapy for the suppression of anti-D immunization and thus prevention of haemolytic disease of the foetus and newborn. However, migration from countries with low health standards and substantial cuts in public health expenses have increased the incidence of anti-D immunization in many "developed" countries. Therefore, this forum focuses on prenatal monitoring standards and treatment strategies in pregnancies with anti-D alloimmunization. The following questions were addressed, and a response was obtained from 12 centres, mainly from Europe.
- Published
- 2010
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19. Recalcitrant Fungal Corneal Ulcer.
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Gounder D and Thool A
- Abstract
The cornea forms the major refracting surface of the eye. Any disease affecting the cornea leads to severe visual impairment. One of the most common pathologies affecting the cornea is infective keratitis. In India, especially in rural areas, infective corneal ulcers are major causes of visual impairment. Medical therapy with antimicrobial medicines is usually started first and if fails to heal the ulcer or there is progressive corneal thinning or corneal perforation then surgical treatments like penetrating keratoplasty are the only modality to salvage the globe integrity. Fungal keratitis particularly in tropical and subtropical areas has a poor prognosis as compared to bacterial keratitis. The main reasons for poor outcomes are delayed diagnosis and a lack of effective antifungal therapies. Over the last decade, significant advances have been made in quick diagnosis in cases of mycotic keratitis and also effective medical treatment. We report a case of a 56-year-old female who was diagnosed with left eye fungal corneal ulcer on systemic and topical antifungal agents for the last two months. She presented to us with an increase in pain, watering, and redness in her left eye for the past two days. On examination, the patient had desmetocele with impending perforation. The patient was advised to undergo therapeutic penetrating keratoplasty in her left eye. Penetrating keratoplasty plays a crucial part in eyes with refractory keratitis, impending perforation, or eyes with corneal perforation. Penetrating keratoplasty in such cases helps to replace the diseased tissue, decrease the infective load, and also helps to restore anatomical integrity of the globe and usable eyesight with good success rate. Early intervention prior to perforation or limbal/scleral extension can lead to better results at least in maintaining the globe integrity., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2022, Gounder et al.)
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- 2022
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20. International Forum on Policies and Practice for Transfusion of ABO and RhD Non-Identical Platelets: Responses.
- Author
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Cardigan R, New HV, Estcourt L, Zhiburt E, Dubey R, Bengtsson J, Jöud M, Castillo C, Cid J, Lozano M, Gounder D, Flanagan P, Morley S, Clarke G, Devine D, Hindawi S, AlOtaibi A, Bub CB, Kutner JM, Ikeda T, Goto N, Okazaki H, Fontaine MJ, Pasion J, Song L, Latham T, Kerkhoffs JL, de Haas M, Zwaginga JJ, Gathof BS, Ommer K, Pirenne F, Raba M, Francois A, Daly J, Powley T, and Dunbar N
- Subjects
- ABO Blood-Group System, Humans, Platelet Transfusion, Policy, Blood Group Incompatibility, Blood Platelets
- Published
- 2022
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21. International Forum on Policies and Practice for Transfusion of ABO and RhD Non-Identical Platelets: Summary.
- Author
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Cardigan R, New HV, Estcourt L, Zhiburt E, Dubey R, Bengtsson J, Jöud M, Castillo C, Cid J, Lozano M, Gounder D, Flanagan P, Morley S, Clarke G, Devine D, Hindawi S, AlOtaibi A, Bub CB, Kutner JM, Ikeda T, Goto N, Okazaki H, Fontaine MJ, Pasion J, Song L, Latham T, Kerkhoffs JL, de Haas M, Zwaginga JJ, Gathof BS, Ommer K, Pirenne F, Raba M, Francois A, Daly J, Powley T, and Dunbar N
- Subjects
- ABO Blood-Group System, Humans, Platelet Transfusion, Policy, Blood Group Incompatibility, Blood Platelets
- Published
- 2022
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22. The New Zealand rare donor program.
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Gounder D
- Subjects
- Blood Transfusion statistics & numerical data, Humans, New Zealand, Blood Banks, Blood Donors supply & distribution, Blood Group Antigens
- Published
- 2016
23. ABO blood group incompatible renal transplantation in New Zealand: a report of the first 20 cases.
- Author
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Ho E, Yasutomi M, Gounder D, and Dittmer I
- Subjects
- Adolescent, Adult, Aged, Child, Female, Follow-Up Studies, Graft Rejection immunology, Graft Survival, Humans, Kidney Failure, Chronic immunology, Kidney Failure, Chronic mortality, Male, Middle Aged, New Zealand, Prospective Studies, Retrospective Studies, Treatment Outcome, Young Adult, ABO Blood-Group System immunology, Blood Group Incompatibility immunology, Kidney Failure, Chronic surgery, Kidney Transplantation mortality, Living Donors
- Abstract
Aim: To report on the first 20 ABO blood group incompatible (ABOi) renal transplants performed in New Zealand., Method: Prospective short-term data and retrospective longer-term follow-up data was collected on the first 20 such transplants between March 2008 and April 2015., Results: Patient and graft survival was excellent at 95% at 12 months and final follow-up (11-85 months; median 31 months). Three serious infections were noted in this time period, one of which resulted in patient death (pneumococcal pneumonia). There were no episodes of anti-ABO blood group antibody mediated rejection. Only one patient was not able to achieve appropriate antibody reduction prior to the planned transplant., Conclusion: ABOi transplantation is a safe and successful treatment option for patients with end stage renal failure who cannot access an ABO compatible live donor.
- Published
- 2016
24. The use of the electronic (computer) cross-match.
- Author
-
Reesink HW, Davis K, Wong J, Schwartz DW, Mayr WR, Devine DV, Georgsen J, Chiaroni J, Ferrera V, Roubinet F, Lin CK, O'Donovan B, Fitzgerald JM, Raspollini E, Villa S, Rebulla P, Makino S, Gounder D, Säfwenberg J, Murphy MF, Staves J, Milkins C, Mercado TC, Illoh OC, and Panzer S
- Subjects
- Humans, Medical Records Systems, Computerized, ABO Blood-Group System analysis, Blood Grouping and Crossmatching methods
- Published
- 2013
- Full Text
- View/download PDF
25. Quality controls of cryopreserved haematopoietic progenitor cells (peripheral blood, cord blood, bone marrow).
- Author
-
Rosskopf K, Ragg SJ, Worel N, Grommé M, Preijers FW, Braakman E, Schuurhuis GJ, van Riet I, Wendel S, Fontão-Wendel R, Lazar A, Goldman M, Halpenny M, Giulivi A, Letcher B, McGann L, Korhonen M, Arvola A, Humpe A, Buwitt-Beckmann U, Wiesneth M, Schauwecker P, Schrezenmeier H, Bönig H, Henschler R, Seifried E, Accorsi P, Bonfini T, Takanashi M, van Beckhoven JM, Brand A, Gounder D, Wong A, Dooccey R, Forrest E, Galea G, Smythe J, Pawson R, Reems JA, Oh J, Reesink HW, and Panzer S
- Subjects
- Female, Hematopoietic Stem Cell Transplantation methods, Hematopoietic Stem Cell Transplantation standards, Humans, Male, Quality Control, Transplantation, Homologous, Cryopreservation methods, Cryopreservation standards, Hematopoietic Stem Cells cytology, Total Quality Management methods, Total Quality Management standards
- Published
- 2011
- Full Text
- View/download PDF
26. Monitoring and treatment of anti-D in pregnancy.
- Author
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Bettelheim D, Panzer S, Reesink HW, Csapo B, Pessoa C, Guerra F, Wendel S, Calda P, Sprogøe U, Dziegiel M, Aitokallio-Tallberg A, Koskinen S, Kuosmanen M, Legler TJ, Stein W, Villa S, Villa MA, Trespidi L, Acaia B, Vandenbussche FP, Brand A, de Haas M, Kanhai HH, Gounder D, Flanagan P, Donegan R, Parry E, Sefonte C, Skulstad SM, Hervig T, Flesland Ø, Zupańska B, Uhrynowska M, Lapaire O, Zhong XY, and Holzgreve W
- Subjects
- Female, Fetal Blood immunology, Fetal Hemoglobin analysis, Humans, Isoantibodies blood, Isoantibodies immunology, Pregnancy, Pregnancy Complications, Hematologic blood, Pregnancy Complications, Hematologic immunology, Pregnancy Complications, Hematologic prevention & control, Rh Isoimmunization immunology, Rh Isoimmunization prevention & control, Rho(D) Immune Globulin, Blood Group Antigens immunology, Isoantibodies administration & dosage, Pregnancy Complications, Hematologic therapy, Rh Isoimmunization therapy, Rh-Hr Blood-Group System immunology
- Abstract
Prophylactic anti-D is a very safe and effective therapy for the suppression of anti-D immunization and thus prevention of haemolytic disease of the foetus and newborn. However, migration from countries with low health standards and substantial cuts in public health expenses have increased the incidence of anti-D immunization in many "developed" countries. Therefore, this forum focuses on prenatal monitoring standards and treatment strategies in pregnancies with anti-D alloimmunization. The following questions were addressed, and a response was obtained from 12 centres, mainly from Europe.
- Published
- 2010
- Full Text
- View/download PDF
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