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Abstract The coupling of circularly polarized light to local band structure extrema ("valleys”) in two dimensional semiconductors promises a new electronics based on the valley degree of freedom. Such pulses, however, couple only to valley charge and not to the valley current, precluding lightwave manipulation of this second vital element of valleytronic devices. Contradicting this established wisdom, we show that the few cycle limit of circularly polarized light is imbued with an emergent vectorial character that allows direct coupling to the valley current. The underlying physical mechanism involves the emergence of a momentum space valley dipole, the orientation and magnitude of which allows complete control over the direction and magnitude of the valley current. We demonstrate this effect via minimal tight-binding models both for the visible spectrum gaps of the transition metal dichalcogenides (generation time ~ 1 fs) as well as the infrared gaps of biased bilayer graphene ( ~ 14 fs); we further verify our findings with state-of-the-art time-dependent density functional theory incorporating transient excitonic effects. Our findings both mark a striking example of emergent physics in the ultrafast limit of light-matter coupling, as well as allowing the creation of valley currents on time scales that challenge quantum decoherence in matter.

The branching ratio of the structure dependent (SD) radiative K+→e+νeγ decay relative to that of the K+→e+νe(γ) decay including the internal bremsstrahlung (IB) process (Ke2(γ)) has been measured in the J-PARC E36 experiment using plastic scintillator/lead sandwich detectors, in contrast to the previous E36 measurement, which used a CsI(Tl) calorimeter. In the analysis, the effect of IB was also taken into account in the SD radiative decay as Ke2γ(γ)SD. By combining the new data with the previous E36 result after revision for the IB correction for Ke2γ(γ)SD, a new value Br(Ke2γ(γ)SD)/Br(Ke2(γ))=1.20±0.07 has been determined. This is consistent with a recent lattice QCD calculation, but larger than the expectation of Chiral Perturbation Theory (ChPT) at order O(p4) and the previous KLOE value. Using the method to relate form factor and branching ratio described in the KLOE paper, the present result is also consistent with the form factor prediction based on a gauged nonlocal chiral quark model, but larger than that from ChPT at order O(p6).

The structure dependent radiative K+→e+νγ (Ke2γSD+) decay was investigated with stopped positive kaons. The e+ momentum spectra containing 574±30 Ke2γSD+ events with a K+→μ+ν (Kμ2) background of 28±19 events were measured with and without a photon in coincidence and analyzed with Monte Carlo simulations for acceptance and detector response to extract the ratio of the branching ratio of the Ke2γSD+ decay and the K+→e+ν decay including the internal bremsstrahlung process (Ke2(γ)). A value of Br(Ke2γSD+)/Br(Ke2(γ))=1.12±0.07stat±0.04syst was obtained. This indicates a partial branching ratio, Br(Ke2γSD+,pe>200MeV/c,Eγ>10MeV)/Br(Kμ2)=(1.85±0.11stat±0.07syst)×10−5, which is 25% (∼2.5σ) higher than the previous experimental result.

Abstract Background Qualitative work has described the differences in prescribing practice across medical and surgical specialties. This study aimed to understand if specialty impacts quantitative measures of prescribing practice. Methods We prospectively analysed the antibiotic prescribing across general medical and surgical teams for acutely admitted patients. Over a 12-month period (June 2016 – May 2017) 659 patients (362 medical, 297 surgical) were followed for the duration of their hospital stay. Antibiotic prescribing across these cohorts was assessed using Chi-squared or Wilcoxon rank-sum, depending on normality of data. The t-test was used to compare age and length of stay. A logistic regression model was used to predict escalation of antibiotic therapy. Results Surgical patients were younger (p

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia. While therapeutic antibodies show clinical activity in CLL patients, resistance inevitably develops resulting in treatment failure. Identifying mechanisms of antibody resistance and methods to reduce resistance would be valuable in managing CLL. Monocyte derived cells (MDCs), also known as nurse like cells (NLCs) in CLL [1,2], are known to be crucial components of the CLL microenvironment network and following “maturation” in in vitro culture systems are able to provide support for the survival of the malignant B cells from CLL patients. In addition to their protective role, MDCs are key effector cells in mediating responses to therapeutic antibody therapies [3]. We have determined that macrophages from patients with early stable CLL are able to elicit superior cytotoxic response to therapeutic antibodies than macrophages derived from patients with progressive CLL. We have exploited this unique finding to gain insight into antibody resistance. Thus, we have profiled monocytes on day 0 and MDCs on day 7 from antibody sensitive and antibody resistant CLL patients (GEO accession number GEO: GSE71409). We show that there are no significant differences in transcriptomes from the monocytes or MDCs derived from sensitive or resistant patient samples. However, we show that MDCs acquire an M2-like macrophage transcriptomic signature following 7 days culture regardless of whether they were derived from sensitive or resistant patient samples. Keywords: Chronic lymphocytic leukemia, Monocyte derived cells, Antibody resistance, Microarray

Background/Aims: The role of cognitive reserve in Parkinson’s disease (PD)-mild cognitive impairment (MCI) is incompletely understood. Methods: The relationships between PD-MCI, years of education, and estimated premorbid IQ were examined in 119 consecutive non-demented PD patients using logistic regression models. Results: Higher education and IQ were associated with reduced odds of PD-MCI in univariate analysis. In multivariable analysis, a higher IQ was associated with a significantly decreased odds of PD-MCI, but education was not. Conclusion: The association of higher IQ and decreased odds of PD-MCI supports a role for cognitive reserve in PD, but further studies are needed to clarify the interaction of IQ and education and the impact of other contributors such as employment and hobbies.