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Breast cancer is the leading cause of death among women worldwide. The main limitations of conventional anti-cancer therapy, including breast cancer treatment, are side effects and the development of resistance to chemotherapeutics. Host defense peptides (HDPs) are bioactive compounds of innate immunity isolated from almost all living organisms, which exhibit wide range of biological activities. This review focuses on the anti-cancer effects of HDPs and their therapeutic potential against breast cancer. Numerous HDPs from different sources, including mammalian and amphibian origin, and their chemically modified analogues, exert the spectrum of anti-cancer activities. These effects include direct disruption of cancer cell membrane, induction of apoptosis, inhibition of angiogenesis and cancer cell proliferation, but also the modulation of anti-cancer immune response. Selected examples of HDPs of different origin and their anti-breast cancer capacities have been reviewed. Conclusively, due to their anti-cancer effects accompanied by substantial selectivity for cancer cells and low toxicity for normal cells, HDPs have been widely recognized as possible therapeutic agents.

The exploration of the universe has recently entered a new era thanks to the multimessenger paradigm, characterized by a continuous increase in the quantity and quality of experimental data that is obtained by the detection of the various cosmic messengers (photons, neutrinos, cosmic rays and gravitational waves) from numerous origins. They give us information about their sources in the universe and the properties of the intergalactic medium. Moreover, multi-messenger astronomy opens up the possibility to search for phenomenological signatures of quantum gravity. On the one hand, the most energetic events allow us to test our physical theories at energy regimes which are not directly accessible in accelerators; on the other hand, tiny effects in the propagation of very high energy particles could be amplified by cosmological distances. After decades of merely theoretical investigations, the possibility of obtaining phenomenological indications of Planck-scale effects is a revolutionary step in the quest for a quantum theory of gravity, but it requires cooperation between different communities of physicists (both theoretical and experimental). This review, prepared within the COST Action CA18108 ‘‘Quantum gravity phenomenology in the multi-messenger approach", is aimed at promoting this cooperation by giving a state-of-the art account of the interdisciplinary expertise that is needed in the effective search of quantum gravity footprints in the production, propagation and detection of cosmic messengers., Talent Scientific Research Program of College of Physics, Sichuan University 1082204112427, Fostering Program in Disciplines Possessing Novel Features for Natural Science of Sichuan University 2020SCUNL209, 1000 Talent program of Sichuan province 2021, Xunta de Galicia, European Commission European Union ERDF, "Maria de Maeztu'' Units of Excellence program MDM-2016-0692, Red Tematica Nacional de Astroparticulas RED2018-102661-T, La Caixa Foundation 100010434, European Commission 847648 LCF/BQ/PI21/11830030 754510, Ministry of Education, Science & Technological Development, Serbia 451-03-9/2021-14/200124, FSR Incoming Postdoctoral Fellowship Ministry of Education, Science and Technological Development, Serbia 451-03-9/2021-14/200124, University of Rijeka grant uniri-prirod-18-48, Croatian Science Foundation (HRZZ) IP-2016-06-9782, Villum Fonden 29405 DGA-FSE 2020-E2117R, European Regional Development Fund through the Center of Excellence (TK133) "The Dark Side of the Universe'' European Regional Development Fund (ESIF/ERDF), Ministry of Education, Youth & Sports - Czech Republic CoGraDS-CZ.02.1.01/0.0/0.0/15 003/0000437, Blavatnik grant, Basque Government IT-97916 Basque Foundation for Science (IKERBASQUE), European Space Agency C4000120711 4000132310, FNRS (Belgian Fund for Research), Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica (PAPIIT), Universidad Nacional Autonoma de Mexico TA100122, National University of La Plata X909 DICYT 042131GR, National Research, Development & Innovation Office (NRDIO) - Hungary 123996, FQXi, Swiss National Science Foundation (SNSF), European Commission 181461 199307, Netherlands Organization for Scientific Research (NWO) 680-91-119 15MV71, Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research (KAKENHI) 20H01899 20H05853 JP21F21789, Estonian Research Council PRG356, Julian Schwinger Foundation, Generalitat Valenciana Excellence PROMETEO-II/2017/033 PROMETEO/2018/165, Istituto Nazionale di Fisica Nucleare (INFN), European ITN project HIDDeN H2020-MSCA-ITN-2019//860881-HIDDeN, Swedish Research Council, European Commission 2016-05996 European Research Council (ERC) European Commission 668679, Advanced ERC grant TReX, Ministry of Education, Universities and Research (MIUR) 2017X7X85K, Fonds de la Recherche Scientifique - FNRS 4.4501.18, Ministry of Research, Innovation and Digitization - Romania PN19-030102-INCDFM PN-III-P4ID-PCE-2020-2374, United States Department of Energy (DOE) DE-SC0020262, Ministry of Science, ICT & Future Planning, Republic of Korea 075-15-2020-778, German Academic Scholarship Foundation German Research Foundation (DFG) 408049454 420243324 425333893 445990517 Germany's Excellence Strategy (EXC 2121 "Quantum Universe'') 390833306 390837967 Federal Ministry of Education & Research (BMBF) 05 A20GU2 05 A20PX1, Centro de Excelencia "Severo Ochoa'' SEV-2016-0588, CERCA program of the Generalitat de Catalunya, Agencia de Gestio D'Ajuts Universitaris de Recerca Agaur (AGAUR) Generalitat de Catalunya 2017-SGR-1469 2017-SGR-929 ICCUB CEX2019-000918-M, National Science Centre, Poland 2019/33/B/ST2/00050 2017/27/B/ST2/01902, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) 306414/2020-1, Dicyt-USACH 041931MF, National Science Fund of Bulgaria KP-06-N 38/11 RCN ROMFORSK 302640, Comunidad de Madrid 2018-T1/TIC-10431 2019-T1/TIC-13177 S2018/NMT-4291, UK Research & Innovation (UKRI), Science & Technology Facilities Council (STFC) ST/T000759/1 ST/P000258/1 ST/T000732/1 ST/V005596/1, Portuguese Foundation for Science and Technology UIDB/00618/2020 UIDB/00777/2020 UIDP/00777/2020 CERN/FIS-PAR/0004/2019 PTDC/FIS-PAR/29436/2017 PTDC/FISPAR/31938/2017 PTDC/FIS-OUT/29048/2017 SFRH/BD/137127/2018, Centre National de la Recherche Scientifique (CNRS), LabEx UnivEarthS ANR-10-LABX-0023 ANR18-IDEX-0001, Junta de Andalucia European Commission A-FQM-053-UGR18, Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2021-03644, National Science Centre Poland Sonata Bis 2019/33/B/ST2/00050 DEC-2017/26/E/ST2/00763, Natural Sciences and Engineering Research Council of Canada (NSERC) DGIID-DGA 2015-E24/2, Spanish Research State Agency and Ministerio de Ciencia e Innovacion MCIN/AEI PID2019-104114RB-C32 PID2019-105544GB-I00 PID2019-105614GB-C21 PID2019106515GB-I00 PID2019-106802GB-I00 PID2019-107394GB-I00 PID2019-107844GB-C21 PID2019-107847RB-C41 MCIN/AEI PGC2018-095328-B-I00 PGC2018-094856-B-I00 PGC2018-096663-B-C41 PGC2018-096663-B-C44 PGC2018-094626-BC21 PGC2018-101858-B-I00 FPA2017-84543-P FPA2016-76005-C2-1-P, Spanish 'Ministerio de Universidades' BG20/00228 Spanish Government PID2020-115845GBI00 Generalitat de Catalunya Comunidad de Madrid S2018/NMT-4291 Spanish Government PID2019-105544GB-I00, Perimeter Institute for Theoretical Physics, Government of Canada through the Department of Innovation, Science and Economic Development, Province of Ontario through the Ministry of Colleges and Universities, Centre National de la Recherche Scientifique (CNRS), Netherlands Organization for Scientific Research (NWO), Fundamental Questions Institute (FQXi), European Cooperation in Science and Technology (COST) CA18108, Research Council of University of Guilan, Iniziativa Specifica TEONGRAV Iniziativa Specifica QGSKY Iniziativa Specifica QUAGRAP Iniziativa Specifica GeoSymQFT, the Spanish Research State Agency and Ministerio de Ciencia e Innovacion MCIN/AEI PID2020-115845GBI00 PID2019-108485GB-I00 PID2020-113334GB-I00 PID2020-113701GB-I00 PID2020-113775GB-I00 PID2020-118159GB-C41 PID2020-118159GA-C42 PRE2019-089024, Rothchild grant UID/MAT/00212/2020 FPU18/04571

We pointed to 4-dimensional generalized Riemannian spaces important for applications in some parts of physics here. Complete metric tensors and its possibilities to be applied in cosmology are analyzed in this paper. We used the results of N. O. Vesic, presented in [14]. At the end of the paper, we studied the diagonal symmetric metric tensor in the cosmological context.

We study a model of tachyon inflation and its attractor solution in the framework of holographic cosmology. The model is based on a holographic braneworld scenario with a D3-brane located at the holographic boundary of an asymptotic ADS5 bulk. The tachyon field that drives inflation is represented by a Dirac-Born-Infeld (DBI) action on the brane. We examine the attractor trajectory in the phase space of the tachyon field for the case of inverse cosine hyperbolic tachyon potential.

In this paper we study a tachyon cosmological model based on dynamics of a 3-brane in the second Randall-Sundrum (RSII) model extended to include matter in the bulk. The presence of matter in the bulk changes warp factor which leads to modification of inflationary dynamics. The additional brane behaves effectively as a tachyon. We calculate numerically observation parameters of inflation: the scalar spectral index ($n_s$) and the tensor-to-scalar ratio ($r$) for the exponential potential of tachyon field., 9 pages, 1 figure, will be published in the Special Issue of Facta Universitatis, Series: Physics, Chemistry and Technology devoted to the SEENET-MTP Balkan Workshop BSW2018 (3-14 June 2018)

In this paper we continue study of tachyon scalar field described by a Dirac-Born-Infeld (DBI) type action with constraints in the cosmological context. The proposed extension of the system introducing an auxiliary field in the minisuperspace framework is discussed. A new equivalent set of constraints is constructed, satisfying the usual regularity conditions., 10 pages, to be published in the Special Issue of the Facta Universitatis Series: Physics, Chemistry and Technology devoted to the SEENET-MTP Balkan Workshop BSW2019 (3-14 June 2018, Nis, Serbia)

In this paper we discuss tachyon scalar field with constraints in the cosmological context. The tachyon field is described by a Dirac-Born-Infeld (DBI) type action. In order to quantize the system using path integral method we propose extension of the system introducing an auxiliary field in the minisuperspace framework.In this paper we discuss tachyon scalar field with constraints in the cosmological context. The tachyon field is described by a Dirac-Born-Infeld (DBI) type action. In order to quantize the system using path integral method we propose extension of the system introducing an auxiliary field in the minisuperspace framework.

The role tachyon fields may play in evolution of early universe is discussed in this paper. We consider the evolution of a flat and homogeneous universe governed by a tachyon scalar field with the DBI-type action and calculate the slow-roll parameters of inflation, scalar spectral index (n), and tensor-scalar ratio (r) for the given potentials. We pay special attention to the inverse power potential, first of all to V (x) ~ x−4, and compare the available results obtained by analytical and numerical methods with those obtained by observation. It is shown that the computed values of the observational parameters and the observed ones are in a good agreement for the high values of the constant X0. The possibility that influence of the radion field can extend a range of the acceptable values of the constant X0 to the string theory motivated sector of its values is briefly considered. [Projekat Ministarstva nauke Republike Srbije, br. 176021, br. 174020 i br. 43011]

A model of tachyon inflation is proposed in the framework of holographic cosmology. The model is based on a holographic braneworld scenario with a D3-brane located at the holographic boundary of an asymptotic ADS$_5$ bulk. The tachyon field that drives inflation is represented by a DBI action on the brane. We solve the evolution equations analytically in the slow-roll regime and solve the exact equations numerically. We calculate the inflation parameters and compare the results with Planck 2018 data., 27 pages 6 figures, substantially revised version accepted for publication in JCAP. A comment on primordial non-Gaussianity added, an appendix on cosmological perturbations added, a minor mistake in the equation for spectral density corrected resulting in slight modifications of the plots, 7 references added, typos corrected

We present results obtained by a software we developed for computing observational cosmological inflation parameters: the scalar spectral index ($n_s$) and the tensor-to-scalar ratio ($r$) for a standard single field and tachyon inflation, as well as for a tachyon inflation in the second Randall-Sundrum model with an additional radion field. The calculated numerical values of observational parameters are compared with the latest results of observations obtained by the Planck Collaboration. The program is written in C/C++. The \textit{GNU Scientific Library} is used for some of the numerical computations and R language is used for data analysis and plots., Comment: 8 pages, 5 figures, based on talk presented at The 10th Jubilee Conference of the Balkan Physical Union (BPU10), 26-30 August 2018 (Sofia, Bulgaria)

We analyze a tachyon cosmological model based on the dynamics of a 3-brane in the bulk of the second Randall–Sundrum model. This model contains extended general warp functions, i.e. generalized bulk geometry. We study a power law warp factor in cosmological context. This type of warp factor generates an inverse power law tachyonic potential.

We discuss the slow-roll parameters of inflation, scalar spectral index n, and tensor-to-scalar ratio r for the model of tachyon inflation in the slow-roll regime. We compare the numerical results obtained for the models with the typical inflationary tachyon potentials.

We analyze the inflationary scenario based on the tachyon field coupled with the radion of the second Randall-Sundrum model (RSII). The tachyon Lagrangian is derived from the dynamics of a 3-brane moving in the five dimensional bulk. The AdS$_5$ geometry of the bulk is extended to include the radion. Using the Hamiltonian formalism we find four nonlinear field equations supplemented by the modified Friedmann equations of the RSII braneworld cosmology. After a suitable rescaling we reduce the parameters of our model to only one free parameter related to the brane tension and the AdS$_5$ curvature. We solve the equations numerically assuming a reasonably wide range of initial conditions determined by physical considerations. Varying the free parameter and initial conditions we confront our results with the Planck 2015 data., Comment: 19 pages, 11 figures, typos corrected, results unchanged, published in Int. J. Mod. Phys. A

The testing represented a prospective study that was performed at the Gynaecology and Obstetrics Clinic "Narodni Front" in Belgrade during a two-year period. The study encompassed female patients with ovarian endometrioma operated with laparoscopic surgery. The research objective was to determine the percentage of occurrence of relapses in patients operated for endometriosis of the ovary in relation to the stage of the disease and the type of performed operation, and which were receiving suppressive therapy with gonadotropin-releasing hormone (GnRH) analogues after the surgery compared to those who were not receiving suppressive therapy after the operation.The recurrence of endometriosis on the ovary of the test and control groups was monitored during the first year after surgery. In all patients ultrasound checks were done every month during the first six months after surgery, and then every three months for the next six months. In all patients in whom the recurrence, i.e. endometrioma on the ovary larger than three cm was revealed postoperatively by ultrasound, the laparoscopic removal of the endometrioma was performed again as well as the histopathological examination of the material.There was no statistically significant difference in the distribution of recurrence of endometriosis between the groups formed according to the type of surgical technique (cystectomy or cystotomy). The recurrence of endometriosis occurred later in the group of patients in which the treatment GnRH analogues was applied after the surgical treatment. The recurrence of endometriosis in more severe stages (Stage III and IV) occurs later in the group of patients in which the treatment GnRH analogues is applied after the surgical treatment.

Since its detection in Portugal in 1999, the pinewood nematode Bursaphelenchus xylophilus (Steiner and Buhrer), a causal agent of Pine Wilt Disease, represents a threat to European forestry. Significant amount of money has been spent on its monitoring and eradication. This paper presents mathematical analysis of spread of pine wilt disease using a set of partial differential equations with space (longitude and latitude) and time as parameters of estimated spread of disease. This methodology can be used to evaluate risk of various assumed entry points of disease and make defense plans in advance. In case of an already existing outbreak, it can be used to draw optimal line of defense and plan removal of trees. Optimization constraints are economic loss of removal of susceptible trees as well as budgetary constraints of workforce cost.

We consider classical and quantum dynamics of a tachyonic system described by a DBI type Lagrangian and inverse cosh potential. This investigation is partially motivated by the string theory and D-brane dynamics, but mostly by their application in cosmological inflation. A formalism for describing dynamics of spatially homogenous tachyon scalar field with this kind of potentials is developed. Classical actions and corresponding quantum propagators in the Feynman path integral approach, both on real and nonarchimedean spaces, are calculated. Possibilities for a quantum adelic generalization of these models are noticed. Cosmological applications are pointed out and discussed.

We investigate the physical conditions and kinematics of broad absorption line region clouds of Si IV in 21 HiBAL Quasars. We use the Danezis et al. method [1], [2], [3] in order to fit and analyze the broad absorption troughs of Si IV resonance lines in the UV region of the electromagnetic spectrum. We find that the BAL flow is not smooth but instead plasma clouds are formed in it. BAL troughs present multicomponent structure which indicates the existence of more than one absorbing cloud in the line of sight, where every absorbing cloud produces a Si IV doublet. We show that the blending of these doublets produces the apparent broad absorption troughs we observe. One of our main achievements is that we managed to decompose and deblend each complex absorption trough to the individual doublets that it consists of. Apart from that, we succeeded in deblending the resonance lines of every doublet. By achieving accurate fits to the BAL troughs we calculated some physical and kinematical parameters that describe the plasma clouds in the line of sight. These parameters are: the radial outflow velocities of the clouds, the random velocities of ions inside each plasma cloud, the apparent optical depth in the center of every absorption component, the FWHM and the equivalent width. As a final step we correlate these physical parameters in order to draw useful conclusions.

We consider a class of tachyon-like potentials, motivated by string theory, D-brane dynamics and inflation theory in the context of classical and quantum mechanics. A formalism for describing dynamics of tachyon fields in spatially homogenous and one-dimensional - classical and quantum mechanical limit is proposed. A few models with concrete potentials are considered. Additionally, possibilities for p-adic and adelic generalization of these models are discussed. Classical actions and corresponding quantum propagators, in the Feynman path integral approach, are calculated in a form invariant on a change of the background number fields, i.e. on both archimedean and nonarchimedean spaces. Looking for a quantum origin of inflation, relevance of p-adic and adelic generalizations are briefly discussed.

This investigation was a prospective study performed at the Gynecological Clinic "Narodni Front" in Belgrade. In the investigated group, endometrial hyperplasia, endometrial polyp, and myoma were diagnosed as the most frequent causes of bleeding during perimenopause. The test group of patients was then subjected to hysterosonography in order to diagnose bleeding etiology, followed by hysteroscopy to confirm its etiology based on hysterosonography. Material was sent for histopathological analysis to definitely confirm the diagnosis. The aim of this study was to the compare the findings of hysterosonography and hysteroscopy to evaluate the sensitivity and efficacy of hysterosonography for diagnosing the etiology of uterine bleeding in perimenopausal women. In the diagnostics of submucosal myoma, endometrial hyperplasia, and endometrial polyps, hysterosonography has proven to be a good screening method. By its use for diagnosing intracavitary uterine pathology, and thus also the pathology of bleeding in perimenopausal women, in many cases hysteroscopy can be avoided. This is a method that is easy to perform, less invasive, less costly to perform, and is well-tolerated.

The aim of this study was to compare hemodynamic changes in the uterine and ovarian arteries between infertile women with moderate and/or severe endometriosis and healthy women. In this prospective study, 99 women in their generative age were subjected to color Doppler ultrasonography to measure hemodynamic parameters from July 2010 to January 2011. The examination was performed during the proliferative or ovulatory phase of the natural menstrual cycle in a random sample of 54 women treated for endometriosis-induced infertility and 45 healthy women were included in control examination procedure. Irrespective of considered stage, endometriosis was most often found in the ovaries, in the sacro-uterine ligaments, peritoneum, and rectovaginally. Resistance to blood flow expressed as the resistance index (RI) in the measured arteries, was significantly higher in severe endometriosis compared to moderate form. Average values of pulsation index (PI) and RI are significantly higher, in both endometriosis stages, compared to measured values in healthy women.

A review of non standard Lagrangians present in modern cosmological models will be considered. Well known example of non standard Lagrangian is Dirac-Born-Infeld (DBI) type Lagrangian for tachyon field. Another type of non standard Lagrangian under consideration contains scalar field which describes open p-adic string tachyon and is called p-adic string theory Lagrangian. We will investigate homogenous cases of both DBI and p-adic fields and obtain Lagrangians of the standard type which have the same equations of motions as aforementioned non standard one.

We present a short review of our results in Quantum Cosmology, in particular on nonarchimedean spaces. As an illustration of our approach we present here our new results on the so‐called “Milne Universe”. The Milne model, we consider, is a special case of the Friedmann‐Lemaitre‐Robertson‐Walker (FLRW) model in the limit of zero mass density. Although its predictions of matter density and spatial curvature contradict observations, we discuss possibilities for a plausible role of this model within the framework of Quantum Cosmology. We present the standard and a new form of the “Milne Universe”, in particular in 2+1 dimensions, and bring these into connection with a few new proposals which have appeared in the last few years.

Preparedness planning for two large mass gatherings events were considered in Serbia in the context of pandemic influenza (H1N1) 2009. Planning included approaches to prevention, detection and response in order to mitigate the situation at this early stage of the epidemic in Serbia. Cases of influenza A(H1N1)v were identified nationally immediately prior to the mass gatherings but also identified in association with both events, as expected in the context of the pandemic situation. This article describes the experiences of planning and the epidemiological situation during the period of the mass gathering events.

We discuss the relevance of the classical and quantum rolling tachyons inflation in the frame of the standard, p-adic and adelic minisuperspace quantum cosmology. The field theory of tachyon matter proposed by Sen in a zero-dimensional version suggested by Kar leads to a model of a particle moving in a constant external field with quadratic damping. We calculate the exact quantum propagator of the model, as well as, the vacuum states and conditions necessary to construct an adelic generalization., 10 pages, no figures

ObjectivesRecent data have suggested that there is a flexibility of borderline values of lung function tests in allowing safe lung resection. The aim of this study was to assess the pattern of postoperative lung function change in patients with chronic obstructive pulmonary disease compared with that of patients with normal lung function, and to compare the operative morbidity and mortality between these groups.MethodsThe study included 35 patients with chronic obstructive pulmonary disease and a control group of 47 patients with normal lung function who underwent lung resection for non–small cell lung cancer. The percent changes of lung function parameters after lung resection and operative morbidity and mortality were compared between groups.ResultsThe mean postoperative loss in forced expiratory volume in the 1st second was significantly less in patients with chronic obstructive pulmonary disease who underwent lobectomy compared with that of patients with normal lung function (11.88% vs 24.6%, P < .05); forced expiratory flows at low lung volumes (50% and 25%) improved in patients who underwent lobectomy. The lung function change after pneumonectomy followed the same trend as that after lobectomy. In patients with chronic obstructive pulmonary disease, forced expiratory volume in the 1st second and small airways function significantly improved after preoperative bronchodilator therapy. In the group with chronic obstructive pulmonary disease, operative mortality was 0 and operative morbidity was 51.43%.ConclusionsBecause the pattern of lung function change is different in patients with chronic obstructive pulmonary disease compared with that of patients with normal lung function, surgery can be offered to carefully selected patients with lung cancer, even in the presence of severely limited lung function.

In der Behandlung der symptomatischen Nierenzyste reichen die Therapieoptionen von einer perkutanen Punktion mit und ohne Sklerosie-rungsmittel (Alkohol 96% oder Tetracyclin 1%) uber die laparoskopische bis hin zur offen-chirurgischen Zystenabtragung.

The principal planar and linear elements of rock structures are defined and classified in order to determine their importance and to eliminate confusions often introduced in published structural studies.

La crise actuelle comme une crise de la société de la connaissance. L'argent et l'information dans les sociétés contemporaines. L'inégalité croissante du monde néoliberiste. Les doctrines cognitives comme doctrines cruciales pour l'infocapitalisme. L'ethnographie de la pensée et sa méthode d'enquête