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1. Prevalence of Hypertension and Its Clinical and Psychological Factors in Type 2 Diabetes Patients in Ghana: A Secondary Analysis of a Cross-Sectional Study

Author

V. Boima, E. Yorke, V. Ganu, L. Twumasi, G. Ekem-Ferguson, D. Dey, I. A. Kretchy, K. Agyabeng, and C. C. Mate-Kole

Subjects
Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Conclusion: The prevalence of HTN among T2DM patients was high; age, caregiver, and personal resilience significantly predicted HTN among T2DM patients. These findings have implications for healthcare providers in implementing strategies to reduce central obesity and incorporating resilience as an important factor in improving treatment outcomes in patients with T2DM.

Published
2024
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2. Atmospheric water transport connectivity within and between ocean basins and land

Author

D. Dey, A. Aldama Campino, and K. Döös

Subjects
Technology, Environmental technology. Sanitary engineering, TD1-1066, Geography. Anthropology. Recreation, Environmental sciences, GE1-350
Abstract

The global atmospheric water transport from the net evaporation to the net precipitation regions has been traced using Lagrangian trajectories. A matrix has been constructed by selecting various group of trajectories based on their surface starting (net evaporation) and ending (net precipitation) positions to show the connectivity of the 3-D atmospheric water transport within and between the three major ocean basins and the global landmass. The analysis reveals that a major portion of the net evaporated water precipitates back into the same region, namely 67 % for the Indian Ocean, 64 % for the Atlantic Ocean, 85 % for the Pacific Ocean and 72 % for the global landmass. It has also been calculated that 58 % of the net terrestrial precipitation was sourced from land evaporation. The net evaporation from the subtropical regions of the Indian, Atlantic and Pacific oceans is found to be the primary source of atmospheric water for precipitation over the Intertropical Convergence Zone (ITCZ) in the corresponding basins. The net evaporated waters from the subtropical and western Indian Ocean were traced as the source for precipitation over the South Asian and eastern African landmass, while Atlantic Ocean waters are responsible for rainfall over North Asia and western Africa. Atlantic storm tracks were identified as the carrier of atmospheric water that precipitates over Europe, while the Pacific storm tracks were responsible for North American, eastern Asian and Australian precipitation. The bulk of South and Central American precipitation is found to have its source in the tropical Atlantic Ocean. The land-to-land atmospheric water transport is pronounced over the Amazon basin, western coast of South America, Congo basin, northeastern Asia, Canada and Greenland. The ocean-to-land and land-to-ocean water transport through the atmosphere was computed to be 2×109 and 1×109 kg s−1, respectively. The difference between them (net ocean-to-land transport), i.e. 1×109 kg s−1, is transported to land. This net transport is approximately the same as found in previous estimates which were calculated from the global surface water budget.

Published
2023
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3. Determinants of willingness to accept kidney transplantation among chronic kidney disease patients in Ghana

Author

V. Boima, M. B. Amissah-Arthur, E. Yorke, D. Dey, Delali Fiagbe, A. E. Yawson, J. Nonvignon, and C. C. Mate-Kole

Subjects
Willingness, Kidney transplantation, Determinants, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background The burden of chronic kidney disease in Africa is three to four times higher compared to high-income countries and the cost of treatment is beyond the reach of most affected persons. The best treatment for end stage renal disease is kidney transplantation which is not available in most African countries. As kidney transplantation surgery is emerging in Ghana, this study assessed factors which could influence the willingness of patients with chronic kidney disease to accept it as a mode of treatment. Methods This cross-sectional survey was carried out among patients with chronic kidney disease in Korle-Bu Teaching Hospital. A consecutive sampling method was used to recruit consenting patients. A structured questionnaire and standardized research instruments were used to obtain information on demographic, socio-economic characteristics, knowledge about transplantation, perception of transplantation, religiosity and spirituality. Logistic regression model was used to assess the determinants of willingness to accept a kidney transplant. Results 342 CKD patients participated in the study of which 56.7% (n = 194) were male. The mean age of the participants was 50.24 ± 17.08 years. The proportion of participants who were willing to accept a kidney transplant was 67.3% (95%CI: 62.0–72.2%). The factors which influenced participants’ willingness to accept this treatment included; willingness to attend a class on kidney transplantation (p

Published
2021
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5. Tapetum-specific expression of harpinPss causes male sterility in transgenic tobacco

Author

B. Madhuri, S. Raut, D. Dey, A. Nazneen, B. Uma, and A. R. Podile

Subjects
exine, hypersensitive response, nicotiana tabacum, signal peptide, ta29 promoter, Biology (General), QH301-705.5, Plant ecology, QK900-989
Abstract

Harpin, an elicitor molecule of bacterial origin induces hypersensitive response (HR) in non-host plants. In an attempt to induce male sterility, harpin was tagged with a signal peptide and expressed downstream to tapetum-specific TA29 promoter resulting in extracellular secretion, subsequent degeneration of tapetum and development of male sterility in tobacco. Putative transgenics were analyzed by PCR amplification of transgene, semiquantitative RT-PCR analysis from total RNA extracts from anther tissue with transgene specific probe, Western blotting using polyclonal antibody raised against harpin, by transmission and scanning electron microscopy, and by confocal microscopy of anthers and pollen at various stages of development. Varying degrees of male sterility (30-100 %) was observed with plants showing complete and partial male sterility as well as several morphological variations were seen especially in leaves and flowers. Further, some of the transgenics showed un-induced of HR-like local lesions in the vegetative tissues. HarpinPss got deposited on the pollen grains upon tapetal degeneration resulting in significant alterations in the morphology of pollen cell wall. However, megagametogenesis was not affected in complete and partial male sterile plants and female gametes were completely fertile. The complete male sterility was attributed to premature tapetal cell death due to sufficient extracellular harpinPss accumulation whereas insufficient protein content might be the reason for partial male sterility. These findings indicate the possible use of cytotoxic harpinPss for the development of male sterile plants.

Published
2012
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9. A survey of public perception, knowledge and factors influencing COVID-19 vaccine acceptability in five communities in Ghana

Author

Yorke, Ernest, Amissah-Arthur, Maame-Boatemaa, Boima, Vincent, D. Dey, Ida, Ganu, Vincent, Fiagbe, Dela, Tetteh, John, Gyaban-Mensah, Anna, Ekem-Furgurson, George, E. Yawson, Alfred, and C. Mate-Kole, Christopher

Subjects
knowledge, COVID-19, Computer Networks and Communications, Hardware and Architecture, community, perception, vaccine acceptability, Software
Abstract

Objective: The present study assessed the public’s perception and Knowledge about COVID-19 and factors that could affect vaccine acceptability in Ghana.Design: We carried out a cross-sectional population-based study. A structured questionnaire was used to capture data on socio-demographic information, knowledge, and the public’s perception of COVID-19 infection, as well as COVID-19 vaccine acceptability from consented participants. Factors affecting vaccine acceptability in Ghana were explored. Robust ordinary least square linear regression analysis was adopted to assess factors associated with vaccine acceptability.Setting: Five communities (Labone, Lartebiorkoshie, Old Fadama, Chorkor, and Ashiyie) in Accra in the Greater Accra district were selected.Participants: WHO modified cluster-sampling method was applied to select households of 997 participants in the five communities.Results: Most respondents were males (57.6%), and the median age of participants was 30 years. The study participants demonstrated a good knowledge of COVID-19 and had high perceptions of the COVID-19 pandemic. The results revealed that the highest educational level, marital status, self-rated Knowledge of COVID-19, Knowledge of COVID-19 definition, Knowledge of COVID-19 symptoms, and perception of the COVID-19 pandemic were significantly associated with vaccine acceptability. Self-reported impact of COVID-19 lockdown/movement restrictions on agriculture and job as a source of livelihood was associated with vaccine acceptability.Conclusion: Higher subjective and objective knowledge of COVID-19 increases vaccine acceptability scores significantly thus, education on COVID-19 and the vaccination against SARS-CoV-2 infection must be intensified to improve vaccine acceptability in Ghana, especially among those with lower educational backgrounds.

Published
2023
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10. Allelopathic Effects of Schima khasiana and Michelia champaca on Germination and Growth of Some Legume and Cereal Crops of North Eastern Himalayan Region

Author

S. K. Sachan, P. Michui, D. Dey, and M. S. Sachan

Subjects
General Medicine
Abstract

Allelopathic influences of Michelia champaca and Schima khasiana were tested in bioassay on two cereal crops (maize-Zea mays and paddy-Oryza sativa), and two legume food crops (rice bean- Vigna umbellata and soybean- Glycine max). The aqueous leaf extracts of fresh dried leaves of above tree species suppressed the growth of test crops. The study revealed that Michelia champaca and Schima khasiana are least toxic to germination, growth and yield of various test crops. Although, germination and growth of paddy and soybean was adversely affected by aqueous extracts of tree species, however, magnitude of toxicity was very less which is evident from the dry matter production of various test crops. Rice bean and maize have been found resistant to phytotoxicity. It is therefore; well evident from the data that maize, paddy, rice bean and soybean can be grown successfully in the proximity of Michelia champaca and Schima khasiana.

Published
2022
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12. Productivity of Groundnut as Influenced by Integrated Use of Lime, Organics, Inorganic Fertilizers, and Biofertilizers in Acidic Soil of Tripura

Author

D. Sen, M. C. Kundu, and D. Dey

Subjects
General Medicine
Abstract

A field experiment was carried out on acidic soil of Khowai district of Tripura during 2017 and 2018 to study the effect of application of various combinations of lime, farmyard manure (FYM), poultry manure (PM), and rhizobium with the recommended doses of NPK on groundnut (Arachis hypogaea L.) productivity. The experiment was conducted in a completely randomized block design with 13 treatments; each replicated thrice. The application of the recommended dose of NPK @ 20:60:40 kg ha-1 along with lime @ 1/5th Lime Requirement (LR), PM @ 5 t ha-1 and seed treatment with Rhizobium @ 20 g kg-1 of seed significantly increased the seed yield and recorded the highest Benefit : Cost ratio (B:C) compared to the recommended dose of NPK alone as well as other treatments combinations. Thus, in achieving higher groundnut productivity with better return in acidic soils of Tripura, integrated use of inorganic fertilizers (NPK @ 20:60:40 kg ha-1) combined with lime @ 1/5th LR, PM @ 5 t ha-1, and seed treatment with Rhizobium @ 20 g kg-1 of seed might be recommended.

Published
2022
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13. Factors Impacting Rhizobium-legume Symbiotic Nitrogen Fixation with the Physiological and Genetic Responses to Overcome the Adverse Conditions: A Review

Author

J.K. Owaresat, M.A. Habib Siam, D. Dey, S. Jabed, F. Badsha, M.R. Islam, and M.S. Kabir

Subjects
General Energy
Abstract

Symbiotic N2 fixation is essential for the plant’s growth because it can fix reactive nitrogen compounds in soil. However, all steps of this process can be hampered by several biotic and abiotic environmental factors. This study mainly focused on discussing the impacts of 12 major factors on this process by reviewing the significant numbers of research works. According to the information from these works, we found some significant physiological and genetic impacts caused by these factors like plasmid deletion, genomic mismanagement, abnormal molecular signals, toxicity, deficiency of minerals, deformation of rhizobial cells, protein denaturation, nucleic acid damage, acetylene reduction and nod factors limitation. Furthermore, expression of heat or acid shock proteins, internal buffering, genes spanning, extracellular immobilization, periplasmic allocation, change of lipopolysaccharides composition, intracellular accumulation of inorganic and organic solutes (Osmolyte) and activation of hydrogenase expression are shown by both micro and macro symbionts as a natural response to adapt to these stress conditions. Though the stress-tolerant strains like HR-3, HR-6, HR-10, HR-12, acta, actP, exoR, lpiA, actR, actS and phrR can be used to sense the external environment and make signals to change gene transcription during the adverse condition, the application of genetic engineering should be expanded more to promote the commercial inoculation by the production of novel stress-tolerant strains or modified genes of rhizobia and legumes.

Published
2023
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17. Clonal Elimination of the Pathogenic Allele as Diagnostic Pitfall in

Author

K, Eggermann, R, Meyer, M, Begemann, D, Dey, E, Bültmann, I, Kurth, G C, Korenke, and C, Knopp

Abstract

Heterozygous gain-of-function variants inWhole-exome sequencing (WES) from DNA extracted from peripheral blood was performed in a 10-year-old female presenting with demyelinating neuropathy, her similarly affected mother and the unaffected maternal grandparents. In addition to evaluation of single nucleotide variants, thorough work-up of copy number and exome-wide variant allele frequency data was performed.Combined analysis of the mother's and daughter's duo-exome data and analysis of the mother's and her parents' trio-exome data initially failed to detect a disease-associated variant. More detailed analysis revealed a copy number neutral loss of heterozygosity of 7q in the mother and led to reanalysis of the exome data for respective sequence variants. Here, a previously reported likely pathogenic variant in theThe report highlights the specific pitfalls of molecular genetic analysis of

Published
2022

18. Cardiometabolic predictors of quantitative high-risk plaque features in a diverse patient population

Author

J Arce, T Kuno, M Fattouh, S Sarkar, J Skendelas, J Daich, A Schenone, L Zhang, P J Slomka, L J Shaw, E Williamson, D S Berman, M J Garcia, D Dey, and L Slipczuk

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background/Introduction Little is known about the prevalence of high-risk plaque features or cardiometabolic predictors in diverse patient populations with underrepresented minorities, in the setting of stable chest pain. Purpose The goals of our study are to 1) describe plaque characteristics in a diverse patient population with underrepresented minorities and 2) characterize cardiometabolic risk factors associated with high prevalence of high-risk quantitative low attenuation noncalcified plaque (LDNCP) burden. Methods Our study included patients with chest pain undergoing CCTA between June 2016 and October 2021 for stable chest pain, who had a complete cardiometabolic panel including lipoprotein(a) and lipid panel, and at least one blood pressure recording before CCTA. Patients with prior PCI or CABG where excluded. CACS was performed before CCTA as per Agatston method and quantified in Agatston Units (AU). Stenosis was graded as per SCCT guidelines by cardiologists and radiologists with level 3 cardiac CT expertise. Plaque measurements were performed using previously validated semiautomated software (AutoPlaque version 2.5) in all patients with CAD-RADS >0 by expert readers blinded from patients' characteristics. Coronary atherosclerotic plaque volumes were measured. Independent predictors for plaque on CCTA among patients were examined using Wilcox multivariate logistic regression. Results A total of 227 consecutive patients were included in our study (see table; age 55.00 [47.50–62.00] years, 63% female, 16% diabetes, 44% hypertension, 40% hyperlipidemia and 32% with current or previous smoking history). Majority of patients were Hispanic (64%) and the rest were Black (27%), White (6%) and Asian (3%). Patients with LDNCP burden >4% were older (60.00 [52.00–66.50] vs 53.00 [43.75–61.00]; p4% had non-obstructive disease (CAD-RADS Patient with LDNCP burden >4% were more likely to be on statin therapy (46.0 vs 30.4%; p=0.041). There was no differences in ethnicity, hemoglobin A1C, TC, LDL-C, HLD-C, TGs, lipoprotein(a), SBP or DBP. By logistic regression analysis, age (OR [CI]: 1.06 [1.01–1.08]), hypertension (2.20, [1.06–4.63]) and hyperlipidemia (2.73 [1.37–5.47]) increased the likelihood of LDNCP burden >4%, but not Lipoprotein (a)>175 nmol/L (OR [CI]: 1.07 [0.48–2.31]. Conclusions In our cohort of patients with high number of unrepresented minorities presenting with stable chest pain, almost all patients (94%) with LDNCP burden >4% had non-obstructive CAD (CAD-RADS4%. Funding Acknowledgement Type of funding sources: None.

Published
2022
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19. Level of vascular inflammation is higher in acute coronary syndromes compared to chronic coronary disease

Author

M Araki, T Sugiyama, A Nakajima, T Yonetsu, L M Seegers, D Dey, H Lee, I McNulty, Y Yasui, Y Teng, T Nagamine, T Kakuta, and I K Jang

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background Vascular inflammation has been recognized as one of the key factors in the pathogenesis of acute coronary syndromes (ACS). Peri-coronary adipose tissue (PCAT) attenuation by computed tomography angiography (CTA) has emerged as a marker specific for coronary artery inflammation. We examined the relationship between clinical presentation and coronary artery inflammation assessed by PCAT attenuation and coronary plaque characteristics. Methods Patients with ACS or stable angina pectoris (SAP) who underwent pre-intervention coronary CTA and optical coherence tomography (OCT) were enrolled. PCAT attenuation was measured around the culprit lesion and in the proximal 40 mm of all coronary arteries. PCAT attenuation and OCT findings were compared between patients with ACS versus SAP. Results Among 471 patients (ACS: 198, SAP: 273), PCAT attenuation was higher in ACS patients than in SAP patients both at the culprit plaque level (−67.5±9.6 Hounsfield unit [HU] vs. −71.5±11.0 HU, p Conclusions PCAT attenuation at culprit plaque, culprit vessel, and pan-coronary levels was higher in ACS patients than in SAP patients. Vascular inflammation appears to play a crucial role in the development of ACS. Funding Acknowledgement Type of funding sources: None.

Published
2022
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20. Epicardial adipose tissue volume and density is associated with cardiac dysfunction in asymptomatic people with type 2 diabetes

Author

S L Ayton, J L Yeo, G S Gulsin, E M Brady, J R Arnold, M P M Graham-Brown, A Singh, D Dey, G P McCann, and A J Moss

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background Type 2 diabetes (T2D) is associated with several perturbations of cardiac structure and function, which are precursors to the development of heart failure. Excess accumulation of epicardial adipose tissue (EAT) may contribute to cardiac dysfunction in individuals with T2D. Lipid-laden adipocytes have a lower computed tomography (CT) attenuation and can be readily identified using cardiac CT. Using a multimodality cardiac imaging approach, we aimed to assess the association of total and low attenuation EAT volume with early markers of cardiac dysfunction in people with T2D. Methods Prospective case-control study, in which participants with and without T2D and no known cardiovascular disease, underwent comprehensive cardiovascular phenotyping including multiparametric cardiac magnetic resonance imaging (MRI), echocardiography and non-contrast cardiac CT. EAT volume was measured from CT scans using a deep learning method and volumes indexed to body surface area. Total EAT was defined according to CT adipose tissue attenuation range of −30 to −190 Hounsfield Units (HU) and low attenuation EAT as −90 to −190 HU. Left ventricular (LV) volumes, function and strain measurements were derived from cardiac MRI images and diastolic function also assessed using echocardiography. Markers of early cardiac dysfunction in those with T2D were assessed for associations with EAT in T2D participants using multivariable linear regression analyses. Results Two hundred and fifty-four participants were included: demographic, anthropometric and imaging variables are displayed in Table 1. Subjects with T2D had increased LV concentric remodelling (higher LV mass/volume ratio), diastolic dysfunction (lower circumferential peak early diastolic strain rate (PEDSR) and average E/e') and reduced systolic function (global longitudinal strain, GLS) compared with controls. Total and low attenuation indexed EAT volumes were 1.6-fold and 2-fold higher, respectively, in participants with T2D compared to controls (Figure 1). After adjustment for age, gender, ethnicity, insulin resistance, systolic blood pressure and waist/hip ratio, total and low attenuation indexed EAT volume were independently associated with LV mass/volume ratio (total indexed EAT volume: β=0.002, p=0.02, low attenuation indexed EAT volume: β=0.004, p=0.01) and LV GLS (total indexed EAT volume: β=−0.02, p Conclusion Total and low attenuation EAT volumes are higher in individuals with T2D, and excess EAT accumulation is independently associated with early markers of cardiac dysfunction. Further studies into the underlying mechanisms of this interaction may facilitate the development of interventions targeted at EAT, which could mitigate against the development of heart failure in people with T2D. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): United Kingdom National Institute for Health Research

Published
2022
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21. Exercise induced coronary inflammation in masters athletes

Author

E Papatheodorou, C Kissel, A Merghani, R Hughes, C Torlasco, A Bakalakos, E Downs, G Parry-Williams, G Finocchiaro, A Malhotra, J C Moon, M Papadakis, K Al Fakih, D Dey, and S Sharma

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background Chronic endurance exercise has been linked to increased prevalence of coronary artery disease (CAD) in male master athletes. Data are limited regarding the presence of exercise-induced coronary inflammation and its association with atherosclerosis in master endurance athletes. Human coronary inflammation can be detected non-invasively by imaging pericoronary adipose tissue (PCAT). We tested the hypothesis that chronic endurance exercise leads to increased prevalence of atherosclerosis via coronary inflammation. Methods Computed tomography coronary angiogram CTCA scans from 2 cohorts of master athletes and age-matched controls, without known risk factors for CAD, were analysed post-hoc and the PCAT attenuation index was calculated around the proximal right coronary artery (FAIRCA). The athletes and the healthy controls also underwent an electrocardiogram, an echocardiogram, a cardiopulmonary exercise test (CPET), a 24-hour Holter tape and a Cardiac Magnetic Resonance (CMR) scan. Results Scans from 243 masters endurance athletes (62% females) and 58 age and Framingham CAD risk score matched healthy controls were analysed. FAIRCA was significantly higher (less negative) in male masters athletes vs female masters athletes [−61.3 Hounsfield Units (HU) vs −62.8 HU, p=0.01], in male athletes vs male controls (−61.3 HU vs −68.6 HU, p Conclusions Masters athletes show increased markers of coronary inflammation. This effect appears to be greater in male masters athletes and is associated with a higher peak VO2 in female masters athletes. However, we did not identify a link between coronary inflammation and coronary atherosclerosis in this cohort. Funding Acknowledgement Type of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): Cardiac Risk in the Young, UK

Published
2022
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22. Influence of gender on coronary atherosclerosis and inflammatory biomarker profile: a CT angiographic study

Author

D Bittner, C Roesner, M Goeller, D Raaz-Schrauder, D Dey, T Kilian, S Achenbach, and M Marwan

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background and aims The burden of coronary atherosclerosis differs between men and women. Beyond traditional cardiovascular risk factors, inflammatory biomarkers can influence plaque formation and progression. We analyzed the influence of gender difference on coronary atherosclerosis and inflammatory cytokines. Methods Coronary CT-Angiography was performed in 301 patients and plaque morphology was quantitatively and qualitatively assessed using semi-automated software (Autoplaque version 2.5, Cedars-Sinai Medical Center, Los Angeles, CA). We analyzed total (TPV), non-calcified (NCPV), calcified (CPV) and low-density plaque volume in mm3 (LDPV, defined as plaque attenuation Results Out of 301 patients, 94 (31%) were female and 207 (69%) were male. As compared to women, men were significantly younger (62 vs. 57 years, p Conclusion Coronary plaque volume and morphology significantly differs between men and women and so does the inflammatory cytokine profile. Albeit significantly lower coronary plaque burden in women, serum levels of interferon-gamma - a known pro-inflammatory cytokine - was significantly higher in women with independent association to gender. Whether interferon-gamma plays contradicting roles in the process of coronary atherosclerosis in men and women needs to be explored in future studies to identify potential gender-specific targets for therapeutic interventions. Funding Acknowledgement Type of funding sources: None.

Published
2022
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23. 18F-sodium fluoride positron emission tomography and coronary plaque radiomics derived from computed tomography angiography for prediction of myocardial infarction

Author

J Kwiecinski, M Kolossvary, E Tzolos, M N Meah, P D Adamson, N V Joshi, M C Williams, E J R Van Beek, D S Berman, P Maurovich-Horvat, D E Newby, M R Dweck, D Dey, and P Slomka

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background Assessments of coronary disease activity with 18F-sodium fluoride positron emission tomography (18F-NaF PET) and radiomics-based precision coronary plaque phenotyping derived from contrast-enhanced computed tomography (CT) have both been shown to enhance risk stratification in patients with coronary artery disease (CAD). To date, no study has investigated whether these two promising methods (which can be obtained during a single imaging session on a hybrid PET/CT scanner) are interchangeable or can provide superior predictive performance when used in combination. Purpose We sought to investigate whether the prognostic information provided by latent morphological radiomic coronary plaque features and assessments of disease activity by 18F-NaF PET are complementary in prediction of myocardial infarction. Methods Patients with known CAD underwent coronary 18F-NaF PET and CT angiography on a hybrid PET/CT scanner. Coronary 18F-NaF uptake was determined by the coronary microcalcification activity (CMA). We performed quantitative plaque analysis of coronary CT angiography datasets. Additionally, coronary plaque segmentations on CT angiography were used to extract 1103 radiomic features. Using weighted correlation network analysis we derived latent morphological features of coronary plaques which were aggregated to patient-level radiomic normograms to predict myocardial infarction using univariate and multivariate Cox proportional hazard models. Results The study cohort comprised of 260 patients with established CAD (age: 65±9 years; 84% men); 179 (69%) participants showed increased coronary 18F-NaF activity (CMA >0). Over 53 [40–59] months of follow-up 18 patients had a myocardial infarction. Using weighted correlation network analysis, from the 1103 radiomic features we derived 15 distinct eigen radiomic features representing latent morphological coronary plaque patterns. On univariate cox modelling 7 of these emerged as predictors of myocardial infarction (Figure). Following adjustments for calcified, noncalcified and low-density noncalcified plaque volumes and 18F-NaF CMA 4 radiomic features (related to texture and geometry) remained independent predictors of myocardial infarction (Figure). Conclusion(s) In patients with established CAD latent morphological features of coronary plaques are predictors of myocardial infarction above and beyond plaque volumes and 18F-NaF uptake. Comprehensive plaque analysis with radiomics may enhance risk stratification of CAD patients. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): NIH, Wellcome Trust

Published
2022
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24. The effect of vitamin K2 supplementation on coronary artery disease in a randomized multicenter trial

Author

S Hasific, K A Oevrehus, J S Lindholt, A Mejldal, D Dey, S Auscher, J Lambrechtsen, S Hosbond, D Alan, G Urbonaviciene, S Becker, L M Rasmussen, and A P Diederichsen

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background Coronary artery calcification (CAC) and especially progression in CAC is a strong predictor of acute myocardial infarction (AMI) and cardiovascular mortality [1]. Observational studies suggest a protective role of vitamin K2 in the development of CAC [2]. Measurement of CAC score in Agatston Units (AU) is common practice, while novel software as AutoPlaque introduces new opportunities to measure coronary plaques [3]. Purpose The aim of this double-blinded randomized multicenter trial is to investigate if vitamin K2 supplementation can reduce the progression of CAC in a population without known coronary disease. Methods AVADEC is a multicenter trial investigating 389 participants randomized to vitamin K2 (720 μg/day) and vitamin D (25 μg/day) versus placebo with a 2-year follow-up from 2018–2019 [4]. The primary endpoint of AVADEC is change in aortic valve calcification. In this substudy, we examined the progression of CAC in participants with no prior coronary disease (no myocardial infarction and/or revascularization) at baseline. Secondary, the change in CAC was evaluated in two prespecified subgroups (low-risk: CAC score Results 304 participants (male, mean age 71 years) with no prior coronary disease were identified. The intervention and placebo groups were similar in all traditional cardiovascular risk factors except familial predisposition for cardiovascular disease (14.4% vs. 6.7%, p=0.046). We found progression of CAC in both the intervention and placebo group from baseline to 24 month follow-up (203 AU vs. 254 AU, p=0.089) (Figure 1). The patients with CAC score Conclusion Patients with no prior coronary disease randomized to vitamin K2 supplementation had a non-significant reduction in CAC development over a 2-year follow-up period. High-risk patients with CAC ≥400 AU had a significantly lower progression of CAC. Additionally, vitamin K2 supplementation significantly reduced the risk of AMI, revascularization and all-cause death. Funding Acknowledgement Type of funding sources: Foundation. Main funding source(s): Danish Cardiovascular Academy (2/3) and the Region of Southern Denmark (1/3).

Published
2022
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25. Pericardial fat from a single horizontal long axis cardiac magnetic resonance cine image: a validation study against three-dimensional cardiac computed tomography

Author

S K Zamani, H Aldiwani, A Razipour, J Wei, A C Kwan, D S Berman, D Dey, C N Bairey Merz, and M D Nelson

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background Excess fat accumulation around the heart (i.e., pericardial fat) is positively associated with cardiovascular disease. Pericardial fat is composed of two distinct depots: (1) epicardial fat, which is a metabolically active adipose tissue located between the heart and the pericardium, and (2) paracardial fat, which is the fat deposit in the mediastinum outside of the parietal pericardium. Both depots are visible on the horizontal long axis cardiac magnetic resonance (CMR) cine (i.e., four chamber view), offering an attractive opportunity to quantify pericardial fat from standard CMR cine images. Purpose To validate pericardial fat area measured from a single horizontal long axis CMR cine against whole-heart volumetric non-contrast cardiac computed tomography (CT) measurements. Methods To accomplish our goal, we leveraged 25 cases from the Women's Ischemia Syndrome Evaluation – Coronary Vascular Dysfunction Continuation cohort who underwent both cardiac MRI and cardiac CT within a median of 35 days apart. For MRI, pericardial fat area was measured from a single high resolution steady state free precession cine image in the horizontal long axis imaging plane using commercially available software (CVI42 V5.13.5, Circle Cardiovascular Imaging, Figure 1A). For CT, pericardial fat volume was measured using a fully automated deep learning algorithm (QFAT 2.0, Figure 1A). Results Fat area measured from a single horizontal long axis cine image was closely related to fat volume measured by three-dimensional cardiac CT, with strong correlations for epicardial fat (R2=0.72, p Conclusions Measuring pericardial fat area, and its constituent parts, from a single horizontal long axis cine image is both feasible and strongly related to reference standard pericardial fat volume by cardiac CT. Funding Acknowledgement Type of funding sources: Public Institution(s). Main funding source(s): National Institutes of Health

Published
2022
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29. A newly designed uncovered biliary stent for palliation of malignant obstruction: results of a prospective study

Author

Christopher Lawrence, Jose Nieto, Willis G. Parsons, André Roy, Nalini M. Guda, Stephen E. Steinberg, Muhammad K. Hasan, Juan Carlos Bucobo, Satish Nagula, Nicholas D. Dey, Jonathan M. Buscaglia, and On behalf of the Study Investigators

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Perforation (oil well), Self Expandable Metallic Stents, Prosthesis design, 03 medical and health sciences, 0302 clinical medicine, Self-expandable metallic stent, Internal medicine, Neoplasms, medicine, Humans, Prospective Studies, Palliative medicine, lcsh:RC799-869, Prospective cohort study, Adverse effect, Aged, Aged, 80 and over, Biliary tract neoplasm, Cholestasis, business.industry, Palliative Care, Gastroenterology, Stent, General Medicine, Jaundice, Hepatology, Middle Aged, equipment and supplies, Surgery, Biliary Tract Surgical Procedures, Treatment Outcome, Self expandable metallic stent, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Female, Stents, lcsh:Diseases of the digestive system. Gastroenterology, medicine.symptom, business, Research Article, Biliary tract neoplasms
Abstract

Background Biliary decompression can reduce symptoms and improve quality of life in patients with malignant biliary obstruction. Endoscopically placed stents have become the standard of care for biliary drainage with the aim of improving hepatic function, relieving jaundice, and reducing adverse effects of obstruction. The purpose of this study was to evaluate the performance characteristics of a newly-designed, uncovered metal biliary stent for the palliation of malignant biliary obstruction. Methods This post-market, prospective study included patients with biliary obstruction due to a malignant neoplasm treated with a single-type, commercially available uncovered self-expanding metal stent (SEMS). Stents were placed as clinically indicated for palliation of jaundice and to potentially facilitate neo-adjuvant chemotherapy. The main outcome measure was freedom from recurrent biliary obstruction (within the stent) requiring re-intervention within 1, 3, and 6 months of stent insertion. Secondary outcome measures included device-related adverse events and technical success of stent deployment. Results SEMS were placed in 113 patients (73 men; mean age, 69); a single stent was inserted in 106 patients, and 2 stents were placed in 7 patients. Forty-eight patients survived and/or completed the 6 month study protocol. Freedom from symptomatic recurrent biliary obstruction requiring re-intervention was achieved in 108 of 113 patients (95.6, 95%CI = 90.0–98.6%) at study exit for each patient. Per interval analysis yielded the absence of recurrent biliary obstruction in 99.0% of patients at 1 month (n = 99; 95%CI = 97.0–100%), 96.6% of patients at 3 months (n = 77; 95%CI = 92.7–100%), and 93.3% of patients at 6 months (n = 48; 95%CI = 86.8–99.9%). In total, only 5 patients (4.4%) were considered failures of the primary endpoint. Most of these failures (4/5) were due to stent occlusion from tumor ingrowth or overgrowth. Overall technical success rate of stent deployment was 99.2%. There were 2 cases of stent-related adverse events (1.8%). There were no cases of post-procedure stent migration, stent-related perforation, or stent-related deaths. Conclusions This newly designed and marketed biliary SEMS system appears to be effective at relieving biliary obstruction and preventing re-intervention within 6 months of insertion in the overwhelming majority of patients. The device has an excellent safety profile, and associated high technical success rate during deployment. Trial registration The study was registered on clinicaltrials.gov on 14 October 2013 and the study registration number is NCT01962168. University of Massachusetts Medical School did not participate in the study.

Published
2020
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30. Salvage Using Polatuzumab Vedotin Based Therapy in Relapsed Refractory Large B-Cell Lymphomas: Early Experience from a Real-World Middle-Income Setting Using Named-Patient Compassionate Access Program

Author

V. S. Radhakrishnan, R. Pincha, V. Raina, J. K. Garg, A. Nag, S. J. Bhave, R. Achari, D. Dey, I. Arun, Z. Lateef, S. S. Vinarkar, M. Parihar, S. Sen, D. K. Mishra, M. Chandy, and R. Nair

Subjects
Hematology
Abstract

Polatuzumab vedotin is a novel immunotherapy antibody-drug conjugate targeting CD79b. It has been used in relapsed/refractory (R/R) large B-cell lymphomas since its FDA approval in 2019. Presently, this drug is unaffordable or unavailable for patients in Lower-Middle Income Countries (LMIC) like India. This is a retrospective study of adult ( 18 years) patients with R/R large B-cell lymphoma failing two prior lines of therapy, who received Polatuzumab based salvage therapy on a compassionate or named-patient access program. Between May 2019 and April 2022, 10 patients received Polatuzumab vedotin, and 9 were evaluable. The most common regimen used was Polatuzumab-Bendamustine-Rituximab. Out of 43 infusions administered, the adverse event profile was manageable [One grade-2 infusion reaction, 4 patients developed grade 3-4 hematological toxicity and none had grade 3-4 non-hematological toxicities]. Ten infusions were administered in the day care service. After a median of 4.5 cycles (range 1-8), 4 patients achieved CR, 2 had partial response (PR), and 3 had progressive disease (PD). With a median follow up of 491 days (range 8-1048 days), four patients are alive (three in CR and one in PR), three patients have died and three patients were lost to follow up. Early real-world experience from a LMIC setting demonstrates feasibility and a favourable safety profile of Polatuzumab vedotin based approach, along with encouraging response rates in a subset of patients.

Published
2022

31. Simple Treadmill Score: Does It Have Better Predictability for Coronary Artery Disease?

Author

M M, Alam, M M, Rahman, T, Parvin, M, Al-Amin, M F, Khaled, P, Bajracharya, M A, Islam, F, Mahjabeen, D, Dey, and S S, Shakil

Subjects
Cross-Sectional Studies, Area Under Curve, Exercise Test, Humans, Female, Coronary Artery Disease, Coronary Angiography
Abstract

Coronary artery disease is one of the most prevalent causes of increasing mortalitiy in current time. Early detection of such dreadful condition by a non-invasive test like exercise treadmill test, is a much-required option to prevent future complications like myocardial infarction. The aim of this study was to find out how different the predictability of simple treadmill score in comparison to other treadmill scores namely the well-known Duke treadmill score and Cleveland clinic score. In a cross-sectional analytical study of total 130 individuals with stable angina were included according to criteria set before the study. The treadmill scores of these patients were calculated and compared to coronary angiogram findings where coronary artery angiograms were done according to clinical need. Simple treadmill test had similar predictability for coronary artery disease when we compared it with much-applied Duke Treadmill Test and Cleveland Clinic Score- which is currently used for mortality prediction. Receiver Operator Characteristics (ROC) Curve showd all scores had around 0.7 area under the curve (AUC) which is highly statistically significant (p0.0001) though simple treadmill score in females has higher sensitivity (92.3%). Simple treadmill score can be considered to exclude female patients from undergoing invasive investigation as it has higher sensitivity than other currently practiced treadmill scores i.e., Duke treadmill score.

Published
2022

32. Calcium scoring in low-dose ungated chest CT scans using convolutional long-short term memory networks

Author

K, Pieszko, A, Shanbhag, A, Killekar, M, Lemley, Y, Otaki, Serge Van, Kriekinge, Paul, Kavanagh, Robert Jh, Miller, Edward J, Miller, Tim, Bateman, D, Dey, D, Berman, and P, Slomka

Abstract

We aimed to develop a novel deep-learning based method for automatic coronary artery calcium (CAC) quantification in low-dose ungated computed tomography attenuation correction maps (CTAC). In this study, we used convolutional long-short -term memory deep neural network (conv-LSTM) to automatically derive coronary artery calcium score (CAC) from both standard CAC scans and low-dose ungated scans (CT-attenuation correction maps). We trained convLSTM to segment CAC using 9543 scans. A U-Net model was trained as a reference method. Both models were validated in the OrCaCs dataset (n=32) and in the held-out cohort (n=507) without prior coronary interventions who had CTAC standard CAC scan acquired contemporarily. Cohen's kappa coefficients and concordance matrices were used to assess agreement in four CAC score categories (very low:10, low:10-100; moderate:101-400 and high400). The median time to derive results on a central processing unit (CPU) was significantly shorter for the conv-LSTM model- 6.18s (inter quartile range [IQR]: 5.99, 6.3) than for UNet (10.1s, IQR: 9.82, 15.9s, p0.0001). The memory consumption during training was much lower for our model (13.11Gb) in comparison with UNet (22.31 Gb). Conv-LSTM performed comparably to UNet in terms of agreement with expert annotations, but with significantly shorter inference times and lower memory consumption.

Published
2022
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33. Clonal Elimination of the Pathogenic Allele as Diagnostic Pitfall in SAMD9L-Associated Neuropathy

Author

K. Eggermann, R. Meyer, M. Begemann, D. Dey, E. Bültmann, I. Kurth, G. C. Korenke, and C. Knopp

Subjects
Genetics, Genetics (clinical)
Abstract

Genes 13(12), 2356 (2022). doi:10.3390/genes13122356 special issue: "Special Issue "Identification of Genes in Rare Syndromes" / Special Issue Editor Dr. Dagmar Wieczorek, Guest Editor", Published by MDPI, Basel

Published
2022
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34. Erratum to: Measurement of exclusive Υ photoproduction from protons in pPb collisions at s NN = 5.02 TeV (The European Physical Journal C, (2019), 79, 3, (277), 10.1140/epjc/s10052-019-6774-8)

Author

Sirunyan, A.M. Tumasyan, A. Adam, W. Ambrogi, F. Asilar, E. Bergauer, T. Brandstetter, J. Brondolin, E. Dragicevic, M. Erö, J. Valle, A.E.D. Flechl, M. Friedl, M. Frühwirth, R. Ghete, V.M. Grossmann, J. Hrubec, J. Jeitler, M. König, A. Krammer, N. Krätschmer, I. Liko, D. Madlener, T. Mikulec, I. Pree, E. Rad, N. Rohringer, H. Schieck, J. Schöfbeck, R. Spanring, M. Spitzbart, D. Taurok, A. Waltenberger, W. Wittmann, J. Wulz, C.-E. Zarucki, M. Chekhovsky, V. Mossolov, V. Gonzalez, J.S. De Wolf, E.A. Croce, D.D. Janssen, X. Lauwers, J. Pieters, M. De Klundert, M.V. Haevermaet, H.V. Mechelen, P.V. Remortel, N.V. Zeid, S.A. Blekman, F. D’Hondt, J. De Bruyn, I. De Clercq, J. Deroover, K. Flouris, G. Lontkovskyi, D. Lowette, S. Marchesini, I. Moortgat, S. Moreels, L. Python, Q. Skovpen, K. Tavernier, S. Doninck, W.V. Mulders, P.V. Parijs, I.V. Beghin, D. Bilin, B. Brun, H. Clerbaux, B. De Lentdecker, G. Delannoy, H. Dorney, B. Fasanella, G. Favart, L. Goldouzian, R. Grebenyuk, A. Kalsi, A.K. Lenzi, T. Luetic, J. Seva, T. Starling, E. Velde, C.V. Vanlaer, P. Vannerom, D. Yonamine, R. Cornelis, T. Dobur, D. Fagot, A. Gul, M. Khvastunov, I. Poyraz, D. Roskas, C. Trocino, D. Tytgat, M. Verbeke, W. Vermassen, B. Vit, M. Zaganidis, N. Bakhshiansohi, H. Bondu, O. Brochet, S. Bruno, G. Caputo, C. Caudron, A. David, P. De Visscher, S. Delaere, C. Delcourt, M. Francois, B. Giammanco, A. Krintiras, G. Lemaitre, V. Magitteri, A. Mertens, A. Musich, M. Piotrzkowski, K. Quertenmont, L. Saggio, A. Marono, M.V. Wertz, S. Zobec, J. Júnior, W.L.A. Alves, F.L. Alves, G.A. Brito, L. Silva, G.C. Hensel, C. Moraes, A. Pol, M.E. Teles, P.R. Chagas, E.B.B.D. Carvalho, W. Chinellato, J. Coelho, E. Da Costa, E.M. Da Silveira, G.G. De Jesus Damiao, D. De Souza, S.F. Malbouisson, H. Jaime, M.M. De Almeida, M.M. Herrera, C.M. Mundim, L. Nogima, H. Rosas, L.J.S. Santoro, A. Sznajder, A. Thiel, M. Manganote, E.J.T. Da Silva De Araujo, F.T. Pereira, A.V. Ahuja, S. Bernardes, C.A. Calligaris, L. Tomei, T.R.F.P. Gregores, E.M. Mercadante, P.G. Novaes, S.F. Padula, S.S. Abad, D.R. Vargas, J.C.R. Aleksandrov, A. Hadjiiska, R. Iaydjiev, P. Marinov, A. Misheva, M. Rodozov, M. Shopova, M. Sultanov, G. Dimitrov, A. Litov, L. Pavlov, B. Petkov, P. Fang, W. Gao, X. Yuan, L. Ahmad, M. Bian, J.G. Chen, G.M. Chen, H.S. Chen, M. Chen, Y. Jiang, C.H. Leggat, D. Liao, H. Liu, Z. Romeo, F. Shaheen, S.M. Spiezia, A. Tao, J. Wang, C. Wang, Z. Yazgan, E. Zhang, H. Zhao, J. Ban, Y. Chen, G. Li, J. Li, Q. Liu, S. Mao, Y. Qian, S.J. Wang, D. Xu, Z. Wang, Y. Avila, C. Cabrera, A. Montoya, C.A.C. Sierra, L.F.C. Florez, C. Hernández, C.F.G. Delgado, M.A.S. Courbon, B. Godinovic, N. Lelas, D. Puljak, I. Cipriano, P.M.R. Sculac, T. Antunovic, Z. Kovac, M. Brigljevic, V. Ferencek, D. Kadija, K. Mesic, B. Starodumov, A. Susa, T. Ather, M.W. Attikis, A. Mavromanolakis, G. Mousa, J. Nicolaou, C. Ptochos, F. Razis, P.A. Rykaczewski, H. Finger, M. Finger, M., Jr. Jarrin, E.C. Khalil, S. Mahmoud, M.A. Mohammed, Y. Bhowmik, S. Dewanjee, R.K. Kadastik, M. Perrini, L. Raidal, M. Veelken, C. Eerola, P. Kirschenmann, H. Pekkanen, J. Voutilainen, M. Havukainen, J. Heikkilä, J.K. Järvinen, T. Karimäki, V. Kinnunen, R. Lampén, T. Lassila-Perini, K. Laurila, S. Lehti, S. Lindén, T. Luukka, P. Mäenpää, T. Siikonen, H. Tuominen, E. Tuominiemi, J. Tuuva, T. Besancon, M. Couderc, F. Dejardin, M. Denegri, D. Faure, J.L. Ferri, F. Ganjour, S. Ghosh, S. Givernaud, A. Gras, P. de Monchenault, G.H. Jarry, P. Leloup, C. Locci, E. Machet, M. Malcles, J. Negro, G. Rander, J. Rosowsky, A. Sahin, M.Ö. Titov, M. Abdulsalam, A. Amendola, C. Antropov, I. Baffioni, S. Beaudette, F. Busson, P. Cadamuro, L. Charlot, C. de Cassagnac, R.G. Jo, M. Kucher, I. Lisniak, S. Lobanov, A. Blanco, J.M. Nguyen, M. Ochando, C. Ortona, G. Paganini, P. Pigard, P. Salerno, R. Sauvan, J.B. Sirois, Y. Leiton, A.G.S. Yilmaz, Y. Zabi, A. Zghiche, A. Agram, J.-L. Andrea, J. Bloch, D. Brom, J.-M. Chabert, E.C. Collard, C. Conte, E. Coubez, X. Drouhin, F. Fontaine, J.-C. Gelé, D. Goerlach, U. Jansová, M. Juillot, P. Bihan, A.-C.L. Tonon, N. Hove, P.V. Gadrat, S. Beauceron, S. Bernet, C. Boudoul, G. Chanon, N. Chierici, R. Contardo, D. Depasse, P. Mamouni, H.E. Fay, J. Finco, L. Gascon, S. Gouzevitch, M. Grenier, G. Ille, B. Lagarde, F. Laktineh, I.B. Lattaud, H. Lethuillier, M. Mirabito, L. Pequegnot, A.L. Perries, S. Popov, A. Sordini, V. Donckt, M.V. Viret, S. Zhang, S. Toriashvili, T. Tsamalaidze, Z. Autermann, C. Feld, L. Kiesel, M.K. Klein, K. Lipinski, M. Preuten, M. Rauch, M.P. Schomakers, C. Schulz, J. Teroerde, M. Wittmer, B. Zhukov, V. Albert, A. Duchardt, D. Endres, M. Erdmann, M. Erdweg, S. Esch, T. Fischer, R. Güth, A. Hebbeker, T. Heidemann, C. Hoepfner, K. Knutzen, S. Merschmeyer, M. Meyer, A. Millet, P. Mukherjee, S. Pook, T. Radziej, M. Reithler, H. Rieger, M. Scheuch, F. Teyssier, D. Thüer, S. Flügge, G. Kargoll, B. Kress, T. Künsken, A. Müller, T. Nehrkorn, A. Nowack, A. Pistone, C. Pooth, O. Stahl, A. Martin, M.A. Arndt, T. Asawatangtrakuldee, C. Beernaert, K. Behnke, O. Behrens, U. Martínez, A.B. Anuar, A.A.B. Borras, K. Botta, V. Campbell, A. Connor, P. Contreras-Campana, C. Costanza, F. Danilov, V. De Wit, A. Pardos, C.D. Damiani, D.D. Eckerlin, G. Eckstein, D. Eichhorn, T. Elwood, A. Eren, E. Gallo, E. Garcia, J.G. Geiser, A. Luyando, J.M.G. Grohsjean, A. Gunnellini, P. Guthoff, M. Harb, A. Hauk, J. Hempel, M. Jung, H. Kasemann, M. Keaveney, J. Kleinwort, C. Knolle, J. Korol, I. Krücker, D. Lange, W. Lelek, A. Lenz, T. Lipka, K. Lohmann, W. Mankel, R. Melzer-Pellmann, I.-A. Meyer, A.B. Meyer, M. Missiroli, M. Mittag, G. Mnich, J. Mussgiller, A. Pitzl, D. Raspereza, A. Savitskyi, M. Saxena, P. Shevchenko, R. Stefaniuk, N. Tholen, H. Onsem, G.P.V. Walsh, R. Wen, Y. Wichmann, K. Wissing, C. Zenaiev, O. Aggleton, R. Bein, S. Blobel, V. Vignali, M.C. Dreyer, T. Garutti, E. Gonzalez, D. Haller, J. Hinzmann, A. Hoffmann, M. Karavdina, A. Kasieczka, G. Klanner, R. Kogler, R. Kovalchuk, N. Kurz, S. Kutzner, V. Lange, J. Marconi, D. Multhaup, J. Niedziela, M. Nowatschin, D. Peiffer, T. Perieanu, A. Reimers, A. Scharf, C. Schleper, P. Schmidt, A. Schumann, S. Schwandt, J. Sonneveld, J. Stadie, H. Steinbrück, G. Stober, F.M. Stöver, M. Troendle, D. Usai, E. Vanhoefer, A. Vormwald, B. Akbiyik, M. Barth, C. Baselga, M. Baur, S. Butz, E. Caspart, R. Chwalek, T. Colombo, F. De Boer, W. Dierlamm, A. Faltermann, N. Freund, B. Friese, R. Giffels, M. Harrendorf, M.A. Hartmann, F. Heindl, S.M. Husemann, U. Kassel, F. Kudella, S. Mildner, H. Mozer, M.U. Müller, T. Plagge, M. Quast, G. Rabbertz, K. Schröder, M. Shvetsov, I. Sieber, G. Simonis, H.J. Ulrich, R. Wayand, S. Weber, M. Weiler, T. Williamson, S. Wöhrmann, C. Wolf, R. Anagnostou, G. Daskalakis, G. Geralis, T. Kyriakis, A. Loukas, D. Topsis-Giotis, I. Karathanasis, G. Kesisoglou, S. Panagiotou, A. Saoulidou, N. Tziaferi, E. Kousouris, K. Papakrivopoulos, I. Evangelou, I. Foudas, C. Gianneios, P. Katsoulis, P. Kokkas, P. Mallios, S. Manthos, N. Papadopoulos, I. Paradas, E. Strologas, J. Triantis, F.A. Tsitsonis, D. Csanad, M. Filipovic, N. Pasztor, G. Surányi, O. Veres, G.I. Bencze, G. Hajdu, C. Horvath, D. Hunyadi, Á. Sikler, F. Vámi, T.Á. Veszpremi, V. Vesztergombi, G. Beni, N. Czellar, S. Karancsi, J. Makovec, A. Molnar, J. Szillasi, Z. Bartók, M. Raics, P. Trocsanyi, Z.L. Ujvari, B. Choudhury, S. Komaragiri, J.R. Bahinipati, S. Mal, P. Mandal, K. Nayak, A. Sahoo, D.K. Swain, S.K. Bansal, S. Beri, S.B. Bhatnagar, V. Chauhan, S. Chawla, R. Dhingra, N. Gupta, R. Kaur, A. Kaur, M. Kaur, S. Kumar, R. Kumari, P. Lohan, M. Mehta, A. Sharma, S. Singh, J.B. Walia, G. Bhardwaj, A. Choudhary, B.C. Garg, R.B. Keshri, S. Kumar, A. Kumar, A. Malhotra, S. Naimuddin, M. Ranjan, K. Shah, A. Sharma, R. Bhardwaj, R. Bhattacharya, R. Bhattacharya, S. Bhawandeep, U. Bhowmik, D. Dey, S. Dutt, S. Dutta, S. Ghosh, S. Majumdar, N. Mondal, K. Mukhopadhyay, S. Nandan, S. Purohit, A. Rout, P.K. Roy, A. Chowdhury, S.R. Sarkar, S. Sharan, M. Singh, B. Thakur, S. Behera, P.K. Chudasama, R. Dutta, D. Jha, V. Kumar, V. Mohanty, A.K. Netrakanti, P.K. Pant, L.M. Shukla, P. Topkar, A. Aziz, T. Dugad, S. Mahakud, B. Mitra, S. Mohanty, G.B. Sur, N. Sutar, B. Banerjee, S. Bhattacharya, S. Chatterjee, S. Das, P. Guchait, M. Jain, S. Kumar, S. Maity, M. Majumder, G. Mazumdar, K. Sahoo, N. Sarkar, T. Wickramage, N. Chauhan, S. Dube, S. Hegde, V. Kapoor, A. Kothekar, K. Pandey, S. Rane, A. Sharma, S. Chenarani, S. Tadavani, E.E. Etesami, S.M. Khakzad, M. Najafabadi, M.M. Naseri, M. Mehdiabadi, S.P. Hosseinabadi, F.R. Safarzadeh, B. Zeinali, M. Felcini, M. Grunewald, M. Abbrescia, M. Calabria, C. Colaleo, A. Creanza, D. Cristella, L. De Filippis, N. De Palma, M. Florio, A.D. Errico, F. Fiore, L. Gelmi, A. Iaselli, G. Lezki, S. Maggi, G. Maggi, M. Marangelli, B. Miniello, G. My, S. Nuzzo, S. Pompili, A. Pugliese, G. Radogna, R. Ranieri, A. Selvaggi, G. Sharma, A. Silvestris, L. 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Monroy, J. Siado, J.E. Snow, G.R. Stieger, B. Godshalk, A. Harrington, C. Iashvili, I. Nguyen, D. Parker, A. Rappoccio, S. Roozbahani, B. Alverson, G. Barberis, E. Freer, C. Hortiangtham, A. Massironi, A. Morse, D.M. Orimoto, T. De Lima, R.T. Wamorkar, T. Wang, B. Wisecarver, A. Wood, D. Bhattacharya, S. Charaf, O. Hahn, K.A. Mucia, N. Odell, N. Schmitt, M.H. Sung, K. Trovato, M. Velasco, M. Bucci, R. Dev, N. Hildreth, M. Anampa, K.H. Jessop, C. Karmgard, D.J. Kellams, N. Lannon, K. Li, W. Loukas, N. Marinelli, N. Meng, F. Mueller, C. Musienko, Y. Planer, M. Reinsvold, A. Ruchti, R. Siddireddy, P. Smith, G. Taroni, S. Wayne, M. Wightman, A. Wolf, M. Woodard, A. Alimena, J. Antonelli, L. Bylsma, B. Durkin, L.S. Flowers, S. Francis, B. Hart, A. Hill, C. Ji, W. Ling, T.Y. Luo, W. Winer, B.L. Wulsin, H.W. Cooperstein, S. Driga, O. Elmer, P. Hardenbrook, J. Hebda, P. Higginbotham, S. Kalogeropoulos, A. Lange, D. Luo, J. Marlow, D. Mei, K. Ojalvo, I. Olsen, J. Palmer, C. Piroué, P. Salfeld-Nebgen, J. Stickland, D. Tully, C. Malik, S. Norberg, S. Barker, A. Barnes, V.E. Das, S. Gutay, L. Jones, M. Jung, A.W. Khatiwada, A. Miller, D.H. Neumeister, N. Peng, C.C. Qiu, H. Schulte, J.F. Sun, J. Wang, F. Xiao, R. Xie, W. Cheng, T. Dolen, J. Parashar, N. Chen, Z. Ecklund, K.M. Freed, S. Geurts, F.J.M. Guilbaud, M. Kilpatrick, M. Li, W. Michlin, B. Padley, B.P. Roberts, J. Rorie, J. Shi, W. Tu, Z. Zabel, J. Zhang, A. Bodek, A. de Barbaro, P. Demina, R. Duh, Y. Ferbel, T. Galanti, M. Garcia-Bellido, A. Han, J. Hindrichs, O. Khukhunaishvili, A. Lo, K.H. Tan, P. Verzetti, M. Ciesielski, R. Goulianos, K. Mesropian, C. Agapitos, A. Chou, J.P. Gershtein, Y. Espinosa, T.A.G. Halkiadakis, E. Heindl, M. Hughes, E. Kaplan, S. Elayavalli, R.K. Kyriacou, S. Lath, A. Montalvo, R. Nash, K. Osherson, M. Saka, H. Salur, S. Schnetzer, S. Sheffield, D. Somalwar, S. Stone, R. Thomas, S. Thomassen, P. Walker, M. Delannoy, A.G. Heideman, J. Riley, G. Rose, K. Spanier, S. Thapa, K. Bouhali, O. Hernandez, A.C. Celik, A. Dalchenko, M. De Mattia, M. Delgado, A. Dildick, S. Eusebi, R. Gilmore, J. Huang, T. Kamon, T. Mueller, R. Pakhotin, Y. Patel, R. Perloff, A. Perniè, L. Rathjens, D. Safonov, A. Tatarinov, A. Akchurin, N. Damgov, J. De Guio, F. Dudero, P.R. Faulkner, J. Gurpinar, E. Kunori, S. Lamichhane, K. Lee, S.W. Mengke, T. Muthumuni, S. Peltola, T. Undleeb, S. Volobouev, I. Wang, Z. Greene, S. Gurrola, A. Janjam, R. Johns, W. Maguire, C. Melo, A. Ni, H. Padeken, K. Alvarez, J.D.R. Sheldon, P. Tuo, S. Velkovska, J. Xu, Q. Arenton, M.W. Barria, P. Cox, B. Hirosky, R. Joyce, M. Ledovskoy, A. Li, H. Neu, C. Sinthuprasith, T. Wang, Y. Wolfe, E. Xia, F. Harr, R. Karchin, P.E. Poudyal, N. Sturdy, J. Thapa, P. Zaleski, S. Brodski, M. Buchanan, J. Caillol, C. Carlsmith, D. Dasu, S. Dodd, L. Duric, S. Gomber, B. Grothe, M. Herndon, M. Hervé, A. Hussain, U. Klabbers, P. Lanaro, A. Levine, A. Long, K. Loveless, R. Rekovic, V. Ruggles, T. Savin, A. Smith, N. Smith, W.H. Woods, N. CMS Collaboration

Abstract

In this article the author name Luigi Calligaris was incorrectly written as A. Calligaris. The original article has been corrected. © CERN for the benefit of the CMS collaboration 2022.

Published
2022

35. Speed Control of a PMDC Motor using MATLAB with Arduino Interface

Author

P. Roy, D. Dey, and S. Biswas

Subjects
L293D chip, PI controller, Arduino UNO microcontroller, PMDC motor
Abstract

Electrical Engineering, Haldia Institute of Technology Electrical Engineering, Haldia Institute of Technology PG Student, Electrical Engineering,IIEST (Shibpur) A closed loop speed control scheme for permanent magnet direct current (PMDC) motor is presented in this article. A Proportional plus Integral (PI) controller is designed in MATLAB Simulink. Control signal received from the computer is fed to an Arduino microcontroller board that generates the necessary pulse width modulated (PWM) signal that drives the PMDC motor through a driver IC. Speed of the motor shaft is received through a tachogenerator which is fed back to the controller block in MATLAB. The controller has been designed in such a way that the motor speed can be maintained at the set reference value even if there are sudden changes in load. Hardware experimental results are reported to demonstrate performance of the developed scheme.

Published
2021
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39. 500 Power Of Zero In Underrepresented Minorities With Chest Pain

Author

M. Fattouh, T. Kuno, J. Skendelas, G. Duarte, C. Fernandez-Hazim, M. Rodriguez-Guerra, P. Neshiwat, A. Schenone, L. Zhang, A. Arbab-Zadeh, M. Blaha, D. Berman, P. Slomka, D. Dey, M. Garcia, and L. Slipczuk

Subjects
Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine
Published
2022
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40. Determinants of Pre-Hospital Delay after Myocardial Infarction in Bangladesh: A Rural Center Experience

Author

M M, Alam, D K, Adhikary, F I, Khaled, M T, Chowdhury, S R, Hassan, A, Saha, F, Mahjabeen, D, Dey, P K, Paul, and S S, Khan

Subjects
Adult, Male, Rural Population, Bangladesh, Cross-Sectional Studies, Percutaneous Coronary Intervention, Time Factors, Myocardial Infarction, Humans, Female, Middle Aged, Hospitals, Aged
Abstract

Determinants of pre-hospital delay after myocardial infarction, strictly among South-Asian rural community, till now is largely unknown. And Bangladesh is not an exception. It is a fact that though around two third of its population still live in villages, we do not know what factors are having influence on such delay. To find out these primers of time consumption before seeking medical help, this is a picture of a medical college hospital situated in a rural precinct. This cross-sectional analytical study was conducted among 98 patients came with Myocardial Infarction (MI) who had met inclusion and exclusion criteria from July 2019 and December 2019. Both STEMINSTEMI patients were selected as they have similar attributes. Data was collected in the coronary care unit using a preformed questionnaire. Among 98 MI patients, where 16 female and 82 male patients had average age 53±12 years. Average income rural community was around 100 USD. Almost 50% of sample were illiterate or below 5th grade. On average 6.6 hours (95% CI: 3.5-12.3) were required to reach CCU after symptom onset, whereas distance to first medical contact (FMC) was about 10.2 Km (95% CI: 6.4-16.2). Median distance to nearest PCI-capable hospital was 140 Km (IQR- 20 Km). Only 28% of patients could reach hospital within 2 hours, where 85% had onset of symptom while they were at home. Tertiary level medical college (74.5%) followed by Upazilla (Sub-urban) government health complex (22.4%) were frequent site of FMC. Principle mode of transport to hospital was CNG-three-wheeler (75% of cases). Logistic regression analysis showed only low literacy was as significant predictor about more than 2 hours pre-hospital delay (OR=2.58; p=0.043). Other factors such as low income (OR=2.51; p=0.126), diabetes mellitus (OR=2.99; p=0.059), female sex (OR=1.56; p=0.753), house wife (OR=1.88; p=0.547), previous MI (OR=1.52; p=1.000), symptom ignorance (OR=2.14; p=0.455) increases pre-hospital delay and distance to FMC10 Km (OR=0.44; p=0.079) no significant prediction of pre-hospital delay after myocardial infarction. As rural community has less access to education low literacy has a significant impact on pre-hospital delay after myocardial infarction. So measures should be taken in rural areas through patient education and social awareness program regarding MI symptom and danger of delayed medical attention.

Published
2021

44. Biological effects of inhaled crude oil vapor. II. Pulmonary effects

Author

Jeffrey S, Fedan, Janet A, Thompson, Kristen A, Russ, Richard D, Dey, Jeffrey S, Reynolds, Michael L, Kashon, Mark C, Jackson, and Walter, McKinney

Subjects
Pharmacology, Inhalation Exposure, Petroleum, Airway Resistance, Animals, Toxicology, Lung, Methacholine Chloride, Rats
Abstract

Workers involved in oil exploration and production in the upstream petroleum industry are exposed to crude oil vapor (COV). COV levels in the proximity of workers during production tank gauging and opening of thief hatches can exceed regulatory standards, and several deaths have occurred after opening thief hatches. There is a paucity of information regarding the effects of COV inhalation in the lung. To address these knowledge gaps, the present hazard identification study was undertaken to investigate the effects of an acute, single inhalation exposure (6 h) or a 28 d sub-chronic exposure (6 h/d × 4 d/wk × 4 wks) to COV (300 ppm; Macondo well surrogate oil) on ventilatory and non-ventilatory functions of the lung in a rat model 1 and 28 d after acute exposure, and 1, 28 and 90 d following sub-chronic exposure. Basal airway resistance was increased 90 d post-sub-chronic exposure, but reactivity to methacholine (MCh) was unaffected. In the isolated, perfused trachea preparation the inhibitory effect of the airway epithelium on reactivity to MCh was increased at 90 d post-exposure. Efferent cholinergic nerve activity regulating airway smooth muscle was unaffected by COV exposure. Acute exposure did not affect basal airway epithelial ion transport, but 28 d after sub-chronic exposure alterations in active (Na

Published
2022
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46. Stability analysis on dual solutions of second- grade fluid flow with heat and mass transfers over a stretching sheet

Author

D. Dey and R. Borah

Subjects
Fluid Flow and Transfer Processes, Materials science, 020209 energy, Mechanical Engineering, 02 engineering and technology, Mechanics, Condensed Matter Physics, Stability (probability), Dual (category theory), Physics::Fluid Dynamics, 020303 mechanical engineering & transports, 0203 mechanical engineering, Mechanics of Materials, 0202 electrical engineering, electronic engineering, information engineering, Fluid dynamics
Abstract

Stability on dual solutions of second-grade fluid flow over a stretching surface with simultaneous thermal and mass diffusions has been studied. The fluid flow is governed by Lorentz force and energy dissipation due to viscosity. Lorentz force is generated due to the application of magnetic field along the transverse direction. In methodology, suitable similarity transformation and MATLAB built-in bvp4c solver technique have been adopted. Effects of some flow parameters are exhibited through figures and tables and a special emphasis is given on the existence of dual solutions. A stability analysis is executed to determine the stable and physically achievable solutions. For the laminar flow, the drag force on the surface for the time-independent case is reduced due to amplifying values of But, it enhances the drag force for the time-dependent case. This shows the effectiveness of the first solution (during steady case) over the unsteady case.

Published
2021
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49. Measurement of the Z boson differential production cross section using its invisible decay mode (Z -> nu(nu)over-bar) in proton-proton collisions at root s=13 TeV

Author

Sirunyan, A. M. Tumasyan, A. Adam, W. Ambrogi, F. and Asilar, E. Bergauer, T. Brandstetter, J. Dragicevic, M. and Eroe, J. Del Valle, A. Escalante Flechl, M. Fruehwirth, R. and Ghete, V. M. Hrubec, J. Jeitler, M. Krammer, N. and Kraetschmer, I. Liko, D. Madlener, T. Mikulec, I. Rad, N. Rohringer, H. Schieck, J. Schoefbeck, R. Spanring, M. and Spitzbart, D. Taurok, A. Waltenberger, W. Wittmann, J. and Wulz, C. -E. Zarucki, M. Chekhovsky, V. Mossolov, V. and Gonzalez, J. Suarez De Wolf, E. A. Di Croce, D. Janssen, X. and Lauwers, J. Pieters, M. Van De Klundert, M. Van De Klundert, M. Van Haevermaet, H. Van Mechelen, P. Van Remortel, N. Abu Zeid, S. Blekman, F. D'Hondt, J. De Bruyn, I. De Clercq, J. Deroover, K. Flouris, G. and Lontkovskyi, D. Lowette, S. Marchesini, I. Moortgat, S. and Moreels, L. Python, Q. Skovpen, K. Tavernier, S. Van Doninck, W. Van Mulders, P. Van Parijs, I. Beghin, D. and Bilin, B. Brun, H. Clerbaux, B. De Lentdecker, G. and Delannoy, H. Dorney, B. Fasanella, G. Favart, L. and Goldouzian, R. Grebenyuk, A. Kalsi, A. K. Lenzi, T. and Luetic, J. Postiau, N. Starling, E. Thomas, L. Vander Velde, C. Vanlaer, P. Vannerom, D. Wang, Q. Cornelis, T. and Dobur, D. Fagot, A. Gul, M. Khvastunov, I. Poyraz, D. Roskas, C. Trocino, D. Tytgat, M. Verbeke, W. and Vermassen, B. Vit, M. Zaganidis, N. Bakhshiansohi, H. and Bondu, O. Brochet, S. Bruno, G. Caputo, C. David, P. and Delaere, C. Delcourt, M. Francois, B. Giammanco, A. and Krintiras, G. Lemaitre, V. Magitteri, A. Mertens, A. and Musich, M. Piotrzkowski, K. Saggio, A. Marono, M. Vidal and Wertz, S. Zobec, J. Alves, F. L. Alves, G. A. Martins Junior, M. Correa Correia Silva, G. Hensel, C. Moraes, A. and Pol, M. E. Rebello Teles, P. Belchior Batista Das Chagas, E. and Carvalho, W. Chinellato, J. Coelho, E. Da Costa, E. M. and Da Silveira, G. G. De Jesus Damiao, D. De Oliveira Martins, C. Fonseca De Souza, S. Malbouisson, H. Matos Figueiredo, D. and Melo De Almeida, M. Mora Herrera, C. Mundim, L. Nogima, H. Prado Da Silva, W. L. Sanchez Rosas, L. J. Santoro, A. and Sznajder, A. Thiel, M. Tonelli Manganote, E. J. Torres Da Silva De Araujo, F. Vilela Pereira, A. Ahuja, S. and Bernardes, C. A. Calligaris, L. Fernandez Perez Tomei, T. R. and Gregores, E. M. Mercadante, P. G. Novaes, S. F. Padula, Sandra S. Romero Abad, D. Aleksandrov, A. Hadjiiska, R. and Iaydjiev, P. Marinov, A. Misheva, M. Rodozov, M. and Shopova, M. Sultanov, G. Dimitrov, A. Litov, L. Pavlov, B. Petkov, P. Fang, W. Gao, X. Yuan, L. Ahmad, M. and Bian, J. G. Chen, G. M. Chen, H. S. Chen, M. Chen, Y. Jiang, C. H. Leggat, D. Liao, H. Liu, Z. Romeo, F. Shaheen, S. M. Spiezia, A. Tao, J. Wang, C. Wang, Z. Yazgan, E. Zhang, H. Zhao, J. Ban, Y. Chen, G. and Levin, A. Li, J. Li, L. Li, Q. Mao, Y. Qian, S. J. Wang, D. Xu, Z. Wang, Y. Avila, C. Cabrera, A. and Carrillo Montoya, C. A. Chaparro Sierra, L. F. Florez, C. and Gonzalez Hernandez, C. F. Segura Delgado, M. A. Courbon, B. and Godinovic, N. Lelas, D. Puljak, I. Sculac, T. and Antunovic, Z. Kovac, M. Brigljevic, V. Ferencek, D. and Kadija, K. Mesic, B. Starodumov, A. Susa, T. Ather, M. W. Attikis, A. Kolosova, M. Mavromanolakis, G. Mousa, J. and Nicolaou, C. Ptochos, F. Razis, P. A. Rykaczewski, H. and Finger, M. Finger, Jr., M. Ayala, E. Jarrin, E. Carrera and Assran, Y. Elgammal, S. Mohammed, Y. Bhowmik, S. De Oliveira, A. Carvalho Antunes Dewanjee, R. K. Ehataht, K. and Kadastik, M. Raidal, M. Veelken, C. Eerola, P. and Kirschenmann, H. Pekkanen, J. Voutilainen, M. Havukainen, J. and Heikkila, J. K. Jarvinen, T. Karimaki, V. Kinnunen, R. and Lampen, T. Lassila-Perini, K. Laurila, S. Lehti, S. and Linden, T. Luukka, P. Maenpaa, T. Siikonen, H. Tuominen, E. Tuominiemi, J. Tuuva, T. Besancon, M. Couderc, F. and Dejardin, M. Denegri, D. Faure, J. L. Ferri, F. Ganjour, S. Givernaud, A. Gras, P. de Monchenault, G. Hamel and Jarry, P. Leloup, C. Locci, E. Malcles, J. Negro, G. and Rander, J. Rosowsky, A. Sahin, M. O. Titov, M. and Abdulsalam, A. Amendola, C. Antropov, I. Beaudette, F. and Busson, P. Charlot, C. de Cassagnac, R. Granier Kucher, I. and Lobanov, A. Blanco, J. Martin Nguyen, M. Ochando, C. and Ortona, G. Paganini, P. Pigard, P. Salerno, R. Sauvan, J. B. Sirois, Y. Leiton, A. G. Stahl Zabi, A. Zghiche, A. Agram, J. -L. Andrea, J. Bloch, D. Brom, J. -M. and Chabert, E. C. Cherepanov, V. Collard, C. Conte, E. and Fontaine, J. -C. Gele, D. Goerlach, U. Jansova, M. Le Bihan, A. -C. Tonon, N. Van Hove, P. Gadrat, S. and Beauceron, S. Bernet, C. Boudoul, G. Chanon, N. and Chierici, R. Contardo, D. Depasse, P. El Mamouni, H. and Fay, J. Finco, L. Gascon, S. Gouzevitch, M. Grenier, G. and Ille, B. Lagarde, F. Laktineh, I. B. Lattaud, H. and Lethuillier, M. Mirabito, L. Pequegnot, A. L. Perries, S. and Popov, A. Sordini, V. Vander Donckt, M. Viret, S. and Zhang, S. Khvedelidze, A. Tsamalaidze, Z. Autermann, C. and Feld, L. Kiesel, M. K. Klein, K. Lipinski, M. Preuten, M. Rauch, M. P. Schomakers, C. Schulz, J. Teroerde, M. and Wittmer, B. Zhukov, V. Albert, A. Duchardt, D. and Endres, M. Erdmann, M. Esch, T. Fischer, R. Ghosh, S. and Gueth, A. Hebbeker, T. Heidemann, C. Hoepfner, K. and Keller, H. Knutzen, S. Mastrolorenzo, L. Merschmeyer, M. and Meyer, A. Millet, P. Mukherjee, S. Pook, T. Radziej, M. and Reithler, H. Rieger, M. Scheuch, F. Schmidt, A. and Teyssier, D. Fluegge, G. Hlushchenko, O. Kress, T. and Kuensken, A. Muller, T. Nehrkorn, A. Nowack, A. Pistone, C. Pooth, O. Roy, D. Sert, H. Stahl, A. Martin, M. Aldaya Arndt, T. Asawatangtrakuldee, C. Babounikau, I. and Beernaert, K. Behnke, O. Behrens, U. Martinez, A. Bermudez and Bertsche, D. Bin Anuar, A. A. Borras, K. Botta, V. and Campbell, A. Connor, P. Contreras-Campana, C. Costanza, F. and Danilov, V. De Wit, A. Defranchis, M. M. Pardos, C. Diez and Damiani, D. Dominguez Eckerlin, G. Eichhorn, T. Elwood, A. Eren, E. Gallo, E. Geiser, A. Luyando, J. M. Grados and Grohsjean, A. Gunnellini, P. Guthoff, M. Haranko, M. and Harb, A. 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Eusebi, R. Gilmore, J. Huang, T. Kamon, T. Luo, S. Mueller, R. Patel, R. and Perloff, A. Pernie, L. Rathjens, D. Safonov, A. and Akchurin, N. Damgov, J. De Guio, F. Dudero, P. R. and Kunori, S. Lamichhane, K. Lee, S. W. Mengke, T. and Muthumuni, S. Peltola, T. Undleeb, S. Volobouev, I. and Wang, Z. Greene, S. Gurrola, A. Janjam, R. Johns, W. and Maguire, C. Melo, A. Ni, H. Padeken, K. Alvarez, J. D. Ruiz Sheldon, P. Tuo, S. Velkovska, J. Verweij, M. and Xu, Q. Arenton, M. W. Barria, P. Cox, B. Hirosky, R. and Joyce, M. Ledovskoy, A. Li, H. Neu, C. Sinthuprasith, T. and Wang, Y. Wolfe, E. Xia, F. Harr, R. Karchin, P. E. and Poudyal, N. Sturdy, J. Thapa, P. Zaleski, S. and Brodski, M. Buchanan, J. Caillol, C. Carlsmith, D. Dasu, S. Dodd, L. Gomber, B. Grothe, M. Herndon, M. Herve, A. Hussain, U. Klabbers, P. Lanaro, A. Long, K. and Loveless, R. Ruggles, T. Savin, A. Smith, N. Smith, W. H. Woods, N. CMS Collaboration

Subjects
High Energy Physics::Phenomenology, High Energy Physics::Experiment, Nuclear Experiment
Abstract

Measurements of the total and differential fiducial cross sections for the Z boson decaying into two neutrinos are presented at the LHC in proton-proton collisions at a center-of-mass energy of 13TeV. The data were collected by the CMS detector in 2016 and correspond to an integrated luminosity of 35.9 fb(-1). In these measurements, events are selected containing an imbalance in transverse momentum and one or more energetic jets. The fiducial differential cross section is measured as a function of the Z boson transverse momentum. The results are combined with a previous measurement of charged-lepton decays of the Z boson. The measured total fiducial cross section for events with Z boson transverse momentum greater than 200 GeV is 3000(-170)(+180) fb.

Published
2021

50. In-medium modification of dijets in PbPb collisions at root s(NN)=5.02 TeV

Author

Sirunyan, A. M. Tumasyan, A. Adam, W. Ambrogi, F. and Asilar, E. Bergauer, T. Brandstetter, J. Dragicevic, M. and Eroe, J. Del Valle, A. Escalante Flechl, M. Fruehwirth, R. and Ghete, V. M. Hrubec, J. Jeitler, M. Krammer, N. and Kraetschmer, I. Liko, D. Madlener, T. Mikulec, I. Rad, N. Rohringer, H. Schieck, J. Schoefbeck, R. Spanring, M. and Spitzbart, D. Taurok, A. Waltenberger, W. Wittmann, J. and Wulz, C. -E. Zarucki, M. Chekhovsky, V. Mossolov, V. and Gonzalez, J. Suarez De Wolf, E. A. Di Croce, D. Janssen, X. and Lauwers, J. Pieters, M. Van De Klundert, M. Van De Klundert, M. Van Haevermaet, H. Van Mechelen, P. Van Remortel, N. Abu Zeid, S. Blekman, F. D'Hondt, J. De Bruyn, I. De Clercq, J. Deroover, K. Flouris, G. and Lontkovskyi, D. Lowette, S. Marchesini, I. Moortgat, S. and Moreels, L. Python, Q. Skovpen, K. Tavernier, S. Van Doninck, W. Van Mulders, P. Van Parijs, I. Beghin, D. and Bilin, B. Brun, H. Clerbaux, B. De Lentdecker, G. and Delannoy, H. Dorney, B. Fasanella, G. Favart, L. and Goldouzian, R. Grebenyuk, A. Kalsi, A. K. Lenzi, T. and Luetic, J. Postiau, N. Starling, E. Thomas, L. Vander Velde, C. Vanlaer, P. Vannerom, D. Wang, Q. Cornelis, T. and Dobur, D. Fagot, A. Gul, M. Khvastunov, I. Poyraz, D. Roskas, C. Trocino, D. Tytgat, M. Verbeke, W. and Vermassen, B. Vit, M. Zaganidis, N. Bakhshiansohi, H. and Bondu, O. Brochet, S. Bruno, G. Caputo, C. David, P. and Delaere, C. Delcourt, M. Francois, B. Giammanco, A. and Krintiras, G. Lemaitre, V. Magitteri, A. Mertens, A. and Musich, M. Piotrzkowski, K. Saggio, A. Marono, M. Vidal and Wertz, S. Zobec, J. Alves, F. L. Alves, G. A. Martins Junior, M. Correa Correia Silva, G. Hensel, C. Moraes, A. and Pol, M. E. Rebello Teles, P. Belchior Batista Das Chagas, E. and Carvalho, W. Chinellato, J. Coelho, E. Da Costa, E. M. and Da Silveira, G. G. De Jesus Damiao, D. De Oliveira Martins, C. Fonseca De Souza, S. Malbouisson, H. Matos Figueiredo, D. and Melo De Almeida, M. Mora Herrera, C. Mundim, L. Nogima, H. Prado Da Silva, W. L. Sanchez Rosas, L. J. Santoro, A. and Sznajder, A. Thiel, M. Tonelli Manganote, E. J. Torres Da Silva De Araujo, F. Vilela Pereira, A. Ahuja, S. and Bernardes, C. A. Calligaris, L. Fernandez Perez Tomei, T. R. and Gregores, E. M. Mercadante, P. G. Novaes, S. F. Padula, Sandra S. Romero Abad, D. Aleksandrov, A. Hadjiiska, R. and Iaydjiev, P. Marinov, A. Misheva, M. Rodozov, M. and Shopova, M. Sultanov, G. Dimitrov, A. Litov, L. Pavlov, B. Petkov, P. Fang, W. Gao, X. Yuan, L. Ahmad, M. and Bian, J. G. Chen, G. M. Chen, H. S. Chen, M. Chen, Y. Jiang, C. H. Leggat, D. Liao, H. Liu, Z. Romeo, F. Shaheen, S. M. Spiezia, A. Tao, J. Wang, C. Wang, Z. Yazgan, E. Zhang, H. Zhao, J. Ban, Y. Chen, G. and Levin, A. Li, J. Li, L. Li, Q. Mao, Y. Qian, S. J. Wang, D. Xu, Z. Wang, Y. Avila, C. Cabrera, A. and Carrillo Montoya, C. A. Chaparro Sierra, L. F. Florez, C. and Gonzalez Hernandez, C. F. Segura Delgado, M. A. Courbon, B. and Godinovic, N. Lelas, D. Puljak, I. Sculac, T. and Antunovic, Z. Kovac, M. Brigljevic, V. Ferencek, D. and Kadija, K. Mesic, B. Starodumov, A. Susa, T. Ather, M. W. Attikis, A. Kolosova, M. Mavromanolakis, G. Mousa, J. and Nicolaou, C. Ptochos, F. Razis, P. A. Rykaczewski, H. and Finger, M. Finger, Jr., M. Ayala, E. Jarrin, E. Carrera and Assran, Y. Elgammal, S. Mohammed, Y. Bhowmik, S. De Oliveira, A. Carvalho Antunes Dewanjee, R. K. Ehataht, K. and Kadastik, M. Raidal, M. Veelken, C. Eerola, P. and Kirschenmann, H. Pekkanen, J. Voutilainen, M. Havukainen, J. and Heikkila, J. K. Jarvinen, T. Karimaki, V. Kinnunen, R. and Lampen, T. Lassila-Perini, K. Laurila, S. Lehti, S. and Linden, T. Luukka, P. Maenpaa, T. Siikonen, H. Tuominen, E. Tuominiemi, J. Tuuva, T. Besancon, M. Couderc, F. and Dejardin, M. Denegri, D. Faure, J. L. Ferri, F. Ganjour, S. Givernaud, A. Gras, P. de Monchenault, G. Hamel and Jarry, P. Leloup, C. Locci, E. Malcles, J. Negro, G. and Rander, J. Rosowsky, A. Sahin, M. O. Titov, M. and Abdulsalam, A. Amendola, C. Antropov, I. Beaudette, F. and Busson, P. Charlot, C. de Cassagnac, R. Granier Kucher, I. and Lobanov, A. Blanco, J. Martin Nguyen, M. Ochando, C. and Ortona, G. Paganini, P. Pigard, P. Salerno, R. Sauvan, J. B. Sirois, Y. Leiton, A. G. Stahl Zabi, A. Zghiche, A. Agram, J. -L. Andrea, J. Bloch, D. Brom, J. -M. and Chabert, E. C. Cherepanov, V. Collard, C. Conte, E. and Fontaine, J. -C. Gele, D. Goerlach, U. Jansova, M. Le Bihan, A. -C. Tonon, N. Van Hove, P. Gadrat, S. and Beauceron, S. Bernet, C. Boudoul, G. Chanon, N. and Chierici, R. Contardo, D. Depasse, P. El Mamouni, H. and Fay, J. Finco, L. Gascon, S. Gouzevitch, M. Grenier, G. and Ille, B. Lagarde, F. Laktineh, I. B. Lattaud, H. and Lethuillier, M. Mirabito, L. Pequegnot, A. L. Perries, S. and Popov, A. Sordini, V. Vander Donckt, M. Viret, S. and Zhang, S. Khvedelidze, A. Tsamalaidze, Z. Autermann, C. and Feld, L. Kiesel, M. K. Klein, K. Lipinski, M. Preuten, M. Rauch, M. P. Schomakers, C. Schulz, J. 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Subjects
Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, High Energy Physics::Experiment, Nuclear Experiment
Abstract

Modifications to the distribution of charged particles with respect to high transverse momentum (p(T)) jets passing through a quark-gluon plasma are explored using the CMS detector. Back-to-back dijets are analyzed in lead-lead and proton-proton collisions at root s(NN) = 5.02 TeV via correlations of charged particles in bins of relative pseudorapidity and angular distance from the leading and subleading jet axes. In comparing the lead-lead and proton-proton collision results, modifications to the charged-particle relative distance distribution and to the momentum distributions around the jet axis are found to depend on the dijet momentum balance x(j) , which is the ratio between the subleading and leading jet p(T). For events with x(j) approximate to 1, these modifications are observed for both the leading and subleading jets. However, while subleading jets show significant modifications for events with a larger dijet momentum imbalance, much smaller modifications are found for the leading jets in these events.

Published
2021

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