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5 results on '"D. Daehnhardt"'

1. Noninvasive Stratum Corneum Sampling and Electron Microscopical Examination of Skin Barrier Integrity: Pilot Study with a Topical Glycerin Formulation for Atopic Dermatitis

Author

D. Daehnhardt, S. Daehnhardt-Pfeiffer, C. Surber, K.-P. Wilhelm, G. Springmann, R. Foelster-Holst, and M. Boettcher

Subjects
Adult, Glycerol, Male, Pathology, medicine.medical_specialty, Skin barrier, Time Factors, Adolescent, Physiology, Chemistry, Pharmaceutical, Skin Absorption, Lipid Bilayers, Pilot Projects, Dermatology, Administration, Cutaneous, Glycerol metabolism, Permeability, Dermatitis, Atopic, Excipients, Microscopy, Electron, Transmission, Stratum corneum, Humans, Medicine, Treatment effect, Sampling (medicine), Direct evaluation, Child, Skin, Pharmacology, integumentary system, business.industry, General Medicine, Atopic dermatitis, medicine.disease, medicine.anatomical_structure, Morphometric analysis, Female, Dermatologic Agents, business
Abstract

Introduction: Therapy of atopic dermatitis encloses use of medicated and nonmedicated preparations. Results of clinical and biophysical procedures indirectly describe the condition of the impaired skin barrier (SB). Direct evaluation of SB integrity is only possible by electron microscopical visualization, e.g. intercellular lipid lamellae (ICLL) organization of the stratum corneum. Method: SB integrity was measured by morphometric analysis of ICLL in healthy and atopic skin and after a 15-day treatment (plus 7-day follow-up) of atopic skin with a glycerin preparation. Results: Significant treatment effect was shown by the restoration of the ICLL. Conclusions: The study reveals that morphometric analysis of ICLL organization is suitable to differentiate between healthy and diseased skin and to semiquantitatively determine the effect of a nonmedicated glycerin formulation. Limitation: Small treatment cohort.

Published
2012

4. The Influence of Two Different Foam Creams on Skin Barrier Repair of Foot Xerosis: A Prospective, Double-Blind, Randomised, Placebo-Controlled Intra-Individual Study.

Author

Daehnhardt D, Daehnhardt-Pfeiffer S, Schulte-Walter J, Neubourg T, Hanisch E, Schmetz C, Breuer M, and Fölster-Holst R

Subjects
Adult, Double-Blind Method, Female, Foot Dermatoses metabolism, Humans, Lipid Metabolism, Male, Microscopy, Electron, Transmission, Middle Aged, Skin drug effects, Skin metabolism, Skin ultrastructure, Water metabolism, Foot Dermatoses drug therapy, Skin Cream therapeutic use
Abstract

Background/aims: Dry skin, or xerosis, is a common condition and a key feature of skin diseases like atopic dermatitis (AD) and ichthyosis vulgaris. Foot xerosis may exist without underlying disease and could be related to very mild forms of AD or ichthyosis vulgaris. The synthesis of important skin lipids (cholesterol, free fatty acids and ceramides) is reduced in xerosis and AD, and reduced lipid synthesis is responsible for a lack of lipids and enzymes in the skin barrier. This slows down reorganisation of the lipid lamellae in the stratum corneum (SC)., Methods: Skin barrier integrity was measured by morphometric analysis of the lipid lamellae in the SC after 4 weeks of treatment with a foam cream (active agent vs. placebo)., Results: Significant treatment effects were shown after 2 and 4 weeks by an increasing amount of intercellular lipids in the SC., Conclusion: This study shows that a quick reorganisation of the SC lipids initiates a good restoration of the whole skin barrier after 4 weeks of treatment with a foam cream., (© 2016 S. Karger AG, Basel.)

Published
2016
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5. Noninvasive stratum corneum sampling and electron microscopical examination of skin barrier integrity: pilot study with a topical glycerin formulation for atopic dermatitis.

Author

Daehnhardt-Pfeiffer S, Surber C, Wilhelm KP, Daehnhardt D, Springmann G, Boettcher M, and Foelster-Holst R

Subjects
Administration, Cutaneous, Adolescent, Adult, Chemistry, Pharmaceutical, Child, Dermatitis, Atopic pathology, Dermatologic Agents chemistry, Dermatologic Agents metabolism, Excipients chemistry, Excipients metabolism, Female, Glycerol chemistry, Glycerol metabolism, Humans, Lipid Bilayers metabolism, Male, Permeability, Pilot Projects, Skin ultrastructure, Time Factors, Dermatitis, Atopic drug therapy, Dermatologic Agents administration & dosage, Excipients administration & dosage, Glycerol administration & dosage, Microscopy, Electron, Transmission, Skin drug effects, Skin metabolism, Skin Absorption
Abstract

Introduction: Therapy of atopic dermatitis encloses use of medicated and nonmedicated preparations. Results of clinical and biophysical procedures indirectly describe the condition of the impaired skin barrier (SB). Direct evaluation of SB integrity is only possible by electron microscopical visualization, e.g. intercellular lipid lamellae (ICLL) organization of the stratum corneum., Method: SB integrity was measured by morphometric analysis of ICLL in healthy and atopic skin and after a 15-day treatment (plus 7-day follow-up) of atopic skin with a glycerin preparation., Results: Significant treatment effect was shown by the restoration of the ICLL., Conclusions: The study reveals that morphometric analysis of ICLL organization is suitable to differentiate between healthy and diseased skin and to semiquantitatively determine the effect of a nonmedicated glycerin formulation., Limitation: Small treatment cohort., (Copyright © 2012 S. Karger AG, Basel.)

Published
2012
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