1. Cross section measurements for production of positron emitters for PET imaging in carbon therapy
- Author
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J.M. Fontbonne, J. Colin, M. Labalme, S. Salvador, D. Cussol, C. Divay, Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique corpusculaire de Caen ( LPCC ), Université de Caen Normandie ( UNICAEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Ecole Nationale Supérieure d'Ingénieurs de Caen ( ENSICAEN ), and Normandie Université ( NU ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS )
- Subjects
medicine.medical_specialty ,Ion beam ,Monte Carlo method ,[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex] ,01 natural sciences ,030218 nuclear medicine & medical imaging ,Ion ,Nuclear physics ,03 medical and health sciences ,0302 clinical medicine ,Positron ,Fragmentation (mass spectrometry) ,0103 physical sciences ,medicine ,Medical physics ,[ PHYS.NEXP ] Physics [physics]/Nuclear Experiment [nucl-ex] ,Nuclear Experiment ,Common emitter ,Physics ,medicine.diagnostic_test ,010308 nuclear & particles physics ,Positron emission tomography ,[PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph] ,Physics::Accelerator Physics ,Nucleon - Abstract
International audience; In light ion beam therapy, positron (β+) emitters are produced by the tissue nuclei through nuclear interactions with the beam ions. They can be used for the verification of the delivered dose using positron emission tomography by comparing the spatial distribution of the β+ emitters activity to a computer simulation taking into account the patient morphology and the treatment plan. However, the accuracy of the simulation greatly depends on the method used to generate the nuclear interactions producing these emitters. In the case of Monte Carlo (MC) simulations, the nuclear interaction models still lack the required accuracy due to insufficient experimental cross section data. This is particularly true for carbon therapy where literature data on fragmentation cross sections of a carbon beam with targets of medical interest are very scarce. Therefore, we performed at GANIL in July 2016 measurements on β+ emitter production cross sections with a carbon beam at 25, 50, and 95 MeV/nucleon on thin targets (C, N, O, and PMMA). We extracted the production cross section of C10,11, N13, and O14,15 that are essential to constrain or develop MC nuclear fragmentation models.
- Published
- 2017