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1. Inhibition of the Stress Response to Breast Cancer Surgery by Regional Anesthesia and Analgesia Does Not Affect Vascular Endothelial Growth Factor and Prostaglandin E2

Author

R. W. G. Watson, D C Moriarty, Michael J. Kerin, Donal J. Buggy, and S C O'Riain

Subjects
Adult, Blood Glucose, Vascular Endothelial Growth Factor A, medicine.medical_specialty, Surgical stress, Angiogenesis, Breast Neoplasms, Dinoprostone, chemistry.chemical_compound, Bolus (medicine), Breast cancer, Anesthesia, Conduction, Stress, Physiological, medicine, Humans, Prospective Studies, Prostaglandin E2, Prospective cohort study, Mastectomy, Aged, Pain Measurement, Pain, Postoperative, business.industry, Venous blood, Middle Aged, medicine.disease, Surgery, Vascular endothelial growth factor, Anesthesiology and Pain Medicine, chemistry, Female, Analgesia, business, medicine.drug
Abstract

Angiogenesis is essential for breast cancer metastases formation and is mediated by vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE2). We hypothesized that serum levels of VEGF and PGE2 are increased by the stress response to breast cancer surgery and attenuated by paravertebral anesthesia and analgesia (PVAA). Thirty women undergoing mastectomy were enrolled in this prospective, randomized study, to receive general anesthesia (GA) and postoperative opioid analgesia (morphine 0.1 mg/kg bolus and patient-controlled infusion) or GA and PVAA (72-h infusion). All patients received rectal diclofenac. Venous blood samples were taken preoperatively and at 4 and 24 h postoperatively for serum glucose, cortisol, C-reactive protein, VEGF, and PGE2. PVAA inhibited the surgical stress response, as indicated by significantly less plasma glucose, cortisol, and C-reactive protein. VEGF and PGE2 values did not differ significantly between the groups. Mean (SD) percentage change in VEGF at 4 and 24 h respectively were 3% +/- 44% versus 9% +/- 80%, P=0.29 and 5% +/- 43% versus -10% +/- 63%, P=0.41 for patients with combined general and PVAA and GA alone, respectively. Mean percentage change in postoperative PGE2 at 4 and 24 h respectively was 10% +/- 17% versus 11% +/- 69%, P=0.29 and 34% +/- 19% versus 47% +/- 18%, P=0.15. We conclude that despite inhibiting the surgical stress response, PVAA had no effect on serum levels of putative breast cancer angiogenic factors, VEGF and PGE2.

Published
2005

2. The effect of rectal diclofenac on pruritus in patients receiving intrathecal morphine

Author

S. Galvin, D. C. Moriarty, Sallyann Colbert, Frank Chambers, and Deirdre M O’Hanlon

Subjects
Chemotherapy, business.industry, medicine.medical_treatment, Analgesic, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Diclofenac, Rectal administration, Anesthesia, medicine, Morphine, Abdomen, Prospective cohort study, business, Abdominal surgery, medicine.drug
Abstract

In this prospective randomised study, pruritus and pain were evaluated in patients undergoing abdominal surgery in which intrathecal morphine was administered. Each patient received intrathecal morphine 0.3 mg prior to induction, followed by a standard anaesthetic. The patients were randomly allocated to one of two groups. One group received 100 mg of rectal diclofenac immediately post-induction. Patients receiving diclofenac had significantly lower pruritus scores at 30 min (p = 0.0076), 2, 4, 8 and 24 h postoperatively, as well as significantly reduced pain scores at each time point (p < 0.0001 at each study interval). Morphine consumption in the first 24 h was also significantly lower in this group. In conclusion, rectal administration of diclofenac significantly reduces the incidence and severity of postoperative pruritus. It also significantly reduces pain and further analgesic requirements postoperatively.

Published
1999

3. Royal Academy of Medicine in Ireland Section of Biomedical Sciences

Author

C. G. Gallagher, J. G. Noble, L. A. J. O’Neill, G. Boland, M. Quinn, M. A. Hollywood, I. D. Hill, C. Sweeney, C. M. O’Connor, B. F. Leek, M. D. Walker, R. G. O’Regan, D. C. Moriarty, A. J. Mackarel, S. O’Connor, K. M. O’Boyle, A. Moore, B. A. Gormley, A. McGuigan, J. J. O’Connor, P. McLoughlin, G. Saleshando, T. Robson, F. M. Keane, N. G. McHale, C. S. Downes, C. E. Herron, C. R. Barnett, H. R. Harty, S. R. McKeown, S. Ryan, S. M. McDonough, A. E. Dusoir, C. N. Scholfield, G. O’Cuinn, E. O’Loinsigh, E. M. Dunne, D. M. Cannon, M. McGuire, K. M. Lagan, S. D. Moore, D. M. Walsh, A. F. L. Cramp, W. T. McNicholas, A. S. Lowe, P. P. Corkery, K. D. McCloskey, J. M. Allen, P. D. Glasgow, D. Cox, C. Hutchinson, D. G. Hirst, T. Quinn, P. Nolan, E. Kilbride, G. McBean, A. K. Keenan, T. M. Curtis, V. C. Cullen, D. A. Hurley, S. Wilson, C. R. Clarke, G. D. Baxter, D. Hirst, H. P. Frizelle, A. Bradford, J. P. Ryan, B. P. Curran, S. W. Kerrigan, A. W. Baird, B. M. Hannigan, O. Carroll, D. J. Fitzerald, K. D. Thornbury, P. J. Magee, G. P. Sergeant, and R. Humphrey

Subjects
business.industry, Section (typography), Medicine, Library science, General Medicine, business
Published
1999

4. Anaesthetic depth at inductionAn evaluation using clinical eye signs and EEG polysomnography

Author

D. C. Moriarty, P. Higgins, C. Crowe, and Camillus K. Power

Subjects
genetic structures, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Eye movement, Polysomnography, Electrooculography, Electroencephalography, Sleep in non-human animals, Sevoflurane, Tonsillectomy, Anesthesiology and Pain Medicine, Upward gaze, Anesthesia, medicine, business, medicine.drug
Abstract

We describe the stages of non-REM sleep induced by anaesthesia with sevoflurane 8% in oxygen and relate these stages to clinical eye positions. We explored John Snow's observation (1847) that ‘when voluntary movement ceases, with the eyes fixed in an upward gaze during the gas induction of anaesthesia, the patient is protected against the risk of mental suffering’ (awareness). Unpremedicated ASA 1 patients undergoing elective tonsillectomy were studied using EEG polysomnographic principles and clinical eye movement tracking. The results expressed as median and range were: latency to stage 1 sleep 4.5 min [2.5–7.5], stage 2 sleep 5 min [3.5–8.5], stage 3 sleep 5.5 min [4–12] and stage 4 sleep 6 min [4.5–15.5]. Eye position 5, the point of no further eye movement, was reached after 9 min [5.5–18.5]. This was significantly longer than the time taken to reach the stage 4 sleep EEG, p

Published
1998

5. Haemodynamic changes with the laryngeal mask airway - off the cuff

Author

Sallyann Colbert, D. C. Moriarty, Deirdre M O’Hanlon, F. Flanagan, and Rory Page

Subjects
Larynx, Male, medicine.medical_specialty, Carotid Artery, Common, Population, Hemodynamics, Laryngeal Masks, Laryngeal mask airway, medicine.artery, Internal medicine, Medicine, Humans, Common carotid artery, education, Aged, education.field_of_study, business.industry, Ultrasonography, Doppler, Blood flow, medicine.anatomical_structure, Anesthesiology and Pain Medicine, Flow velocity, Anesthesia, Cuff, Cardiology, business, Blood Flow Velocity
Abstract

The cross-sectional area of the common carotid artery bulb was measured using a 5 MHz pulse wave Doppler probe in a patient undergoing general anaesthesia using a laryngeal mask airway (LMA). A simultaneous measurement of blood velocity was performed to allow determination of the blood flow. Following inflation of the cuff on the LMA, the cross-sectional area of the right carotid artery bulb decreased from 1.09 to 0.89 cm 2 , flow velocity increased 120 to 176 cm s −1 and the blood flow increased from 130.8 to 156.6 cm 3 s −1 . On the left the cross-sectional area decreased from 1.16 to 1.13 cm 2 , the velocity increased 136 to 151 cm s −1 and the blood flow increased from 157·8 to 170·6 cm 3 s −1 . While a reduction in cross-sectional area was observed in the carotid bulb in this patient, this was accompanied by an increase in the velocity and a consequent increase in blood flow. In patients with atheromatous disease involving the carotid arteries this decrease in cross-sectional area may prove clinically significant. The use of the LMA may not be suitable for this population.

Published
1997

6. National scientific medical meeting 1995 abstracts

Author

S. Norris, C. Collins, J. Hegarty, C. O’Farrelly, J. Carton, L. Madrigal, D. P. O’Donoghue, H. Holloway, J. F. Fielding, W. Mullins, S. W. Hone, M. Donnelly, F. Powell, A. W. Blayney, E. A. Cahill, S. F. Daly, M. J. Turner, P. A. Sullivan, M. McLoughlin, M. M. Skelly, H. E. Mulcahy, T. Connell, C. Duggan, M. J. Duffy, A. Troy, K. Sheahan, A. Whelan, C. M. Herra, C. T. Keane, H. Johnson, B. Lee, E. Doherty, T. McDonnell, D. Mulherin, O. FitzGerald, B. Bresnihan, H. M. Hassett, A. Boyce, V. Greig, C. O’Herlihy, P. P. A. Smyth, E. F. Roche, I. McCormack, E. Tempany, M. J. Cullen, D. F. Smith, Y. McBrinn, B. Murray, R. Freaney, D. Keating, M. J. McKenna, J. A. O’Hare, H. Alam, Q. Raza, M. Geoghegan, S. Killalea, M. Hall, J. Feely, L. Kyne, B. O’Hara, M. Cullen, I. M. Rea, J. P. Donnelly, R. W. Stout, P. Lacey, M. J. Donnelly, J. McGrath, T. P. Hennessy, C. V. I. Timon, D. Hyde, H. X. Xia, M. Buckley, C. O’Morain, S. Keating, H. Xia, J. P. McGrath, R. C. Stuart, P. Lawlor, P. J. Byrne, T. N. Walsh, T. P. J. Hennessy, M. Duffy, M. Tubridy, J. Redmond, K. Monahan, R. P. Murphy, D. R. Headon, T. O’Gorman, F. M. O’Reilly, C. Darby, G. M. Murphy, A. Murphy, M. Codd, P. Dervan, D. Lawlor, S. O. Loughlin, N. Flanagan, R. Watson, L. Barnes, C. Kilgallen, E. Sweeney, A. Mynes, D. Mooney, I. Donoghue, O. Browne, J. A. Kirrane, D. McKenna, M. Young, E. O’Toole, S. O’Briain, U. Srinivasan, C. Feighery, N. Leonard, E. Jones, M. A. Moloney, D. G. Weir, M. Lawler, A. O’Neill, H. Gowing, D. Pamphilon, S. R. McCann, G. O’Toole, A. Orren, C. M. Seifer, D. C. Crowley, G. J. Sheehan, T. Deignan, J. Kelly, V. J. Tormey, J. Faul, C. Leonard, C. M. Burke, L. W. Poulter, S. Lynch, G. McEntee, O. Traynor, E. Barry, P. Costello, A. Keavney, R. Willoughby, C. O’Donnell, M. Cahill, A. Earley, P. Eustace, R. Osborne, C. Saidlear, B. Holmes, A. Early, A. P. Moran, A. Neisser, R. J. Polt, H. Bernheimer, M. Kainz, B. Schwerer, L. Gallagher, R. Firth, N. Kennedy, E. McGilloway, N. Tubridy, K. Shields, W. K. Cullen, M. J. Rowan, A. R. Moore, M. Rowan, D. Coakley, B. Lawlor, G. Swanwick, R. Al-Naeemi, R. Murphy, N. M. Codd, M. Goggins, N. P. Kennedy, B. L. Mallon, H. Mulcahy, M. Skelly, D. O. Donoghue, D. McCarthy, A. Saunders, D. J. Veale, J. J. F. Belch, D. Breathnach, E. Murphy, G. Kernohan, K. Gibson, A. G. Wilson, G. W. Duff, N. de Vries, L. B. A. van de Putte, J. Donoghue, F. O’Kelly, Z. Johnson, T. Maher, A. Moran, C. Keane, D. O’Neill, N. Horgan, J. M. Barragry, D. M. Campbell, M. Behan, P. R. O’Connell, V. S. Donnelly, D. Crowley, M. Geary, P. Boylan, M. Fanagan, K. Hickey, T. Teoh, M. Doyle, R. Harrison, D. Lyons, Y. Shenouda, M. Coughlan, P. McKenna, P. Lenehan, M. Foley, P. Kelehan, P. Ravichandran, M. Kelly, A. Conroy, C. Fitzpatrick, D. Egan, C. L. Regan, B. V. McAdam, P. McParland, G. A. FitzGerald, D. J. Fitzgerald, S. C. Sharma, K. Foran, C. Barry-Kinsella, R. F. Harrison, F. J. Gillespie, P. O’Mahony, M. Boyle, M. J. White, F. Donohoe, Y. Birrane, M. Naughton, R. B. Fitzsimons, M. Piracha, S. McConkey, E. Griffin, E. Hayes, T. Clarke, N. Parfrey, K. Butler, A. J. Malone, P. J. Kearney, P. F. Duggan, A. Lane, R. Keville, M. Turner, S. Barry, D. Sloan, S. Gallagher, M. Darby, P. Galligan, J. Stack, N. Walsh, M. O’Sullivan, M. Fitzgerald, D. Meagher, S. Browne, C. Larkin, P. Casey, E. O’Callaghan, S. Rooney, E. Walsh, M. Morris, T. Burke, M. Roe, C. Maher, M. Wrigley, M. Gill, M. Burgess, E. Corcoran, D. Walsh, B. Gilmer, C. B. Hayes, L. Thornton, J. Fogarty, R. Lyons, M. O’Connor, V. Delaney, K. Buckley, D. Lillis, V. Delany, C. Hayes, P. Dack, D. Igoe, H. J. O’Neill, P. Kelly, D. McKeown, L. Clancy, G. Varghese, S. Hennessy, J. J. Gilmartin, K. Birthistle, D. Carrington, H. Maguire, P. Atkinson, C. Foley-Nolan, M. Lynch, B. Cryan, D. Whyte, C. Conlon, V. Kucinskas, U. Usinskiene, I. Sakalyte, E. Dawson, K. Molloy, N. Goulden, J. Doyle, E. Lawlor, M. G. Harrington, N. El-Nageh, M. -L. Nolan, J. O’Riordan, G. Judge, G. Crotty, T. Finch, M. Borton, T. Barnes, O. Gilligan, G. Lee, R. Limmer, M. Madden, C. Bergin, A. O’Leary, F. Mulcahy, F. Wallis, M. Glennon, M. Cormican, U. NiRiain, M. Heiginbothom, F. Gannon, T. Smith, C. O’Sullivan, R. Hone, D. A. Caugant, C. A. P. Fijen, E. J. Van Schalkwyk, G. J. Coetzee, U. Ni Riain, M. G. Cormican, L. Park, J. Flynn, V. Regazzoli, M. Hayes, G. Nicholson, P. Higgins, N. Flynn, G. Corbett-Feeney, D. J. Conway, N. J. O’Higgins, S. Rajendiran, J. Byrne, E. Kilfeather, P. Dingle, M. Hunter, S. K. Al-Ghazal, P. Stanley, J. Palmer, A. Hong, P. Saxby, D. Sheehan, I. Regan, J. O’Mullane, M. Ni Chaoimh, M. Leahy, J. J. Heffron, M. Lehane, C. Keohane, N. O’Leary, M. Sheehan, E. Renny-Walsh, M. J. Whelton, C. T. Doyle, J. Webster, N. Benjamin, S. FitzGerald, J. S. Chadha, M. G. FitzGerald, G. R. FitzGerald, L. Hemeryck, P. McGettigan, J. Golden, N. Arthur, S. Y. Wen, P. Deegan, T. Cooke, G. I. Adebayo, P. Gaffney, M. Sinnot, D. O’Riordan, T. Hayes, C. M. O’Connor, M. X. FitzGerald, C. Costello, G. Finlay, J. Hayes, C. O’Connor, K. McMahon, S. Hone, J. Robertson, R. Coakley, S. O’Neill, M. Walsh, J. McCarthy, D. Lannon, A. E. Wood, R. Sharkey, E. Mulloy, M. Long, I. Kilgallen, V. Tormey, S. Horne, T. Feeney, Ó. Ó Muiré, M. J. Griffin, D. Hughes, A. Knaggs, D. Magee, C. McCrory, B. March, D. Phelan, M. White, J. Fabry, D. Buggy, C. Cooney, E. Aziz, D. O’Keefe, A. J. McShane, J. Boylan, E. Tobin, C. Motherway, F. Colreavy, N. Denish, R. Dwyer, A. Bergin, K. O’Brien, R. MacSullivan, K. D. Carson, W. P. Blunnie, D. C. Moriarty, B. Kinirons, B. Lyons, N. Cregg, W. Casey, K. P. Moore, S. A. Colbert, C. Ecoffey, D. O’Gorman, J. Fitzgerald, P. Diamond, M. B. Codd, D. D. Sugrue, J. Kellett, M. Tighe, C. J. McKenna, J. Galvin, H. A. McCann, A. Scallon, A. Fraser, M. Norton, G. Tomkin, I. Graham, A. Byrne, M. Maher, N. Moran, D. Fitzgerald, D. O’Callaghan, D. Coyle, A. G. Nugent, C. McGurk, G. D. Johnston, A. Nugent, B. Silke, N. Murphy, L. Jennings, D. Pratico, C. Doyle, T. Hennessy, H. McCann, D. Sugrue, S. Donnelly, A. Hennessy, C. Hartigan, D. MacDonald, S. Blake, D. McDonald, D. Dominque, S. R. McMechan, G. MacKenzie, J. Allen, G. T. Wright, G. J. Dempsey, M. Crawley, J. Anderson, A. A. J. Adgey, M. T. Harbinson, N. P. S. Campbell, C. M. Wilson, P. K. Ellis, E. M. McIlrath, A. McShane, T. V. Keaveny, K. Rabenstein, F. Scheller, D. Pfeiffer, C. Urban, I. Moser, G. Jobst, A. Manz, S. Verpoorte, F. Dempsey, D. Diamond, M. Smyth, E. Dempsey, V. Hamilton, J. Twomey, R. Crowley, L. Fenelon, F. Walsh, J. McCann, P. McDonagh, E. McGovern, D. Luke, K. Crowley, D. Mannion, D. Murphy, K. Clarkson, E. Carton, I. Leonard, D. O’Toole, M. Staunton, M. Griffin, D. Owens, P. Collins, A. Johnson, G. H. Tomkin, N. A. Herity, J. D. Allen, R. O’Moore, G. M. Crotty, M. DeArce, K. Nikookam, P. Keenan, D. Cregan, N. O’Meara, S. Forman, D. A. Cusack, and B. Farrell

Subjects
medicine.medical_specialty, business.industry, Family medicine, medicine, MEDLINE, General Medicine, business
Published
1995

7. 19th Sir peter freyer memorial lecture and surgical symposium 16th and 17th September 1994

Author

D. A. McEvoy, B. Connolly, V. Donohue, D. O’Halpin, H. Rowley, T. P. O’Dywer, C. Timon, J. A. McKeever, M. A. Stokes, J. G. Bannigan, M. J. Early, D. M. Baker, Van-Tam Nguyen, D. Bush, J. Jones, J. B. Bourke, K. S. Cross, G. Durkan, M. Stokes, T. Carroll, T. Gorey, K. O’Malley, D. Mulcahy, D. McCormack, J. McElwain, S. C. Natin, T. N. Walsh, T. P. J. Hennessy, K. Carson, R. Page, W. Blunnie, D. C. Moriarty, R. W. G. Watson, D. M. Bouchier-Hayes, H. Abdih, C. J. Kelly, M. Barry, P. Burke, A. Tanner, D. J. Bouchier-Hayes, T. O’Sullivan, A. F. Horgan, D. H. L. Chin, J. A. Mannick, M. L. Rodrick, N. Finnegan, S. T. O’Sullivan, S. F. Wolf, M. C. Barry, C. Condron, R. G. K. Watson, J. D. Evans, C. A. Maxwell-Armstrong, M. K. Barry, K. K. Singh, P. Ralston, C. D. Auld, M. Henderson, J. McCormick, A. D. F. Walls, I. Keogh, M. Kerin, D. O’Hanlon, S. Walsh, P. Kent, J. Callaghan, H. F. Given, P. Madhavan, B. Golden, F. Khan, E. Murphy, N. Couse, G. Burke, P. V. Delaney, R. McLoughlin, P. Kenny, D . O’Hanlon, H. Grimes, S. Reid, P. Neary, M. Nassralla, T. K. Neelamekam, P. Horgan, O. Traynor, P. G. Horgan, J. Hyland, D. M. O’Hanlon, C. O’Boyle, M. J. Duffy, E. W. M. McDermott, D. Reilly, J. J. Fennelly, N. J. O’Higgins, A. McNamara, H. Mullett, D. O’Riordan, E. McDermott, M. Sharp, N. O’Higgins, M. Murphy, M. Little, D. Maher, A. Khalid, P. McCarthy, I. F. Given, C. Bolger, J. P. Phillips, C. Gilligan, S. Zareb, C. Roake, D. S. O’Riordain, D. Farley, C. Grant, J. van Heerden, D. P. O’Brien, M. J. Flynn, F. B. V. Keane, B. Sweeney, D. O’Riordain, A. J. Curran, W. Joyce, D. Smith, H. Gallagher, M. A. Walsh, D. Bouchier-Hayes, J. Phillips, T. O’Brien, S. W. Yusuf, A. C. Perkins, M. Frier, P. W. Wenham, B. R. Hopkinson, G. S. Makin, R. Hind, W. Yusuf, S. C. Whitaker, R. E. Hind, T. A. M. Chuter, G. C. Durkan, M. J. Grenell, M. C. Regan, T. F. Gorey, C. F. Castineira, S. J. Sheehan, M. Wali, M. P. Colgan, D. J. Moore, G. D. Shanik, G. McGreal, J. Kelly, D. Hehir, M. P. Brady, D. M. Sibbering, P. A. M. Holland, A. R. M. Wilson, R. W. Blarney, M. Khurrum Baig, N. Mulligan, B. Farrell, F. O. Cunningham, M. Magd-Eldin, P. Keeling, Y. A. Gul, S. W. Yeo, U. D. Khan, F. Lennon, M. F. Shine, V. Kalidasan, O. Fulena, E. J. Guiney, R. J. Fitzgerald, M. Corbally, A. E. Wood, C. M. Reardon, G. T. McGreal, D. J. Hehir, J. A. O’Donnell, W. O. Kirwan, A. A. Mahomed, A. Keshgar, R. Surna, M. T. Corbally, S. O’Rourke, I. Beckingham, M. C. Bishop, J. Husain, N. Hegarty, J. Calleary, I. Rafi, M. Gilmore, S. M. Saleem, H. P. Singh, T. Aherne, H. P. Redmond, J. McCarthy, D. M. Mulcahy, P. Nicholson, P. Harrington, T. Sharif, H. Smyth, G. Fenelon, J. Pegum, J. Corrigan, A. Jenkinson, A. A. El-Magbri, M. A. Gussail, M. A. Smew, A. Martin, M. Bennett, M. A. Farrell, C. Curran, M. J. Kerin, M. T. P. Caldwell, P. J. Byrne, S. Duggan, A. S. Jones, J. K. Field, D. Monaghan, C. Condren, S. Crerand, M. Kavanagh, P. Dervan, B. Hurson, K. Aiyaswami, D. Evoy, M. Walsh, B. Garrihy, S. Kaf Al-Ghazal, J. O’Donoghue, J. McCann, S. Wagstaff, C. Conroy, M. Dolan, L. Smith, L. Klenerman, J. Noel, V. Waide, D. O’Sullivan, C. Biyani, C. Powell, M. Heal, R. Surana, A. Khan, T. Lynch, T. Sami, W. Baluch, D. Hickey, M. Donovan, P. McLean, D. Murphy, S. Johnston, V. Rastogi, J. Doyle, J. R. Flynn, P. Kelly, M. F. Neligan, S. W. MacGowan, O. Sharkey, A. Bhojwani, C. Barry Walsh, E. Kay, C. Milbum, M. Leader, J. McDermott, D. Moriarty, P. Caushaj, J. M. Fitzpatrick, D. Byrne, W. P. Hederman, N. K. O’Malley, K. H. Chan, P. Fleming, G. C. O’Sullivan, K. Aizaz, A. F. O’Donnell, D. A. Luke, E. M. McGovern, N. Patil, P. Gormley, and P. M. McCarthy

Subjects
medicine.medical_specialty, business.industry, medicine, Physiology, Medical physics, General Medicine, Session (computer science), business
Published
1994

8. Royal academy of medicine in Ireland section of biomedical sciences

Author

G. Barniville, P. J. Hartigan, A. Lydon, O. Rawas, J. F. Andrews, B. Donne, M. Kelly, C. Brady, B. McNamara, D. Taylor, A. Ishtiaq, P. Glacken, M. O’brien, D. Moraes, J. Tyrrell, P. M. E. McCormack, J. Feely, J. Stinson, L. Hemeryck, R. Chan, L. Clancy, S. C. Sharma, C. Barry-Kinsella, E. Cortell, R. F. Harrison, J. J. O’connor, S. J. Trout, Z. L. Kruk, K. Foran, B. Han, J. P. Kelly, J. M. O’donnell, M. A. Hollywood, N. G. McHale, J. B. Kearns, O. Hardiman, A. M. Harris, C. S. Harris, K. D. O’halloran, A. Bradford, D. McKeogh, P. Nolan, R. G. O’regan, M. McDermott, V. R. Maddineni, R. K. Mirakhur, A. R. Cooper, R. S. J. Clarke, W. O’brien, J. Tarpey, C. Cooney, W. P. Blunnie, D. C. Moriarty, Y. Niveditha, D. J. O’donovan, B. Manning, E. Furlong, F. Martin, D. P. Brazil, E. M. Smyth, A. K. Keenan, N. Nunan, D. Faustman, X. Li, R. M. Sklar, R. H. Brown, S. O’gorman, J. Bannigan, J. B. Moynihan, H. P. Staunton, C. S. Breathnach, L. Lynch, M. Bowen, L. Malone, A. J. Cunningham, N. C. Armstrong, J. M. Allen, J. J. Strain, B. M. McDermott, C. J. Bailey, P. R. Flatt, D. P. Megaw, F. J. Murphy, D. J. Reen, G. D’arcy, T. Cooke, R. Sheahan, D. Foley, M. Reilly, W. Jauch, M. Gibney, P. Crean, G. Gearty, M. Walsh, J. McGinley, J. Hurley, D. Phelan, M. Neligan, R. G. Luckwill, M. J. Rowan, R. Anwyll, M. Wall, J. A. Houghton, M. Heatley, C. Whiteside, P. Maxwell, P. Toner, D. M. Walsh, A. S. Lowe, G. D. Baxter, A. J. Bell, T. C. Lee, B. P. McNamara, P. J. Prendergast, D. P. Campion, and B. F. Leek

Subjects
General Medicine
Published
1992

9. Evidence for analgesia mediated by peripheral opioid receptors in inflamed synovial tissue

Author

Andrew J Lawrence, A. Michalkiewiczi, W. P. Blunnie, Girish P Joshi, and D. C. Moriarty

Subjects
Adult, Male, (+)-Naloxone, Pharmacology, Arthroscopy, Radioligand Assay, Synovitis, medicine, Humans, Knee, Pharmacology (medical), Receptor, Morphine Derivatives, Pain, Postoperative, Morphine, business.industry, General Medicine, Venous blood, medicine.disease, medicine.anatomical_structure, Nociception, Opioid, Receptors, Opioid, Female, Analgesia, Synovial membrane, business, medicine.drug
Abstract

Intra-articular morphine (5 mg in 25 ml) was administered to patients for post-operative analgesia following arthroscopic knee surgery. At various time intervals, 30 min to 4 h post morphine, venous blood samples were taken in order to determine plasma levels of morphine and its primary metabolites, morphine-3-glucuronide and morphine-6-glucuronide. Measurable amounts of morphine and morphine-3-glucuronide were found in the plasma of 7/10 patients whereas morphine-6-glucuronide was detected in only 2/10 patients. The plasma levels of morphine were lower than that regarded sufficient for post-operative analgesia in all but two patients, indicating a possibility of peripheral analgesia. [p]In addition, synovial biopsy samples were assayed for the presence of opioid binding sites. Tissue samples from 11 different patients were analysed and 6/11 exhibited specific binding of [3H]naloxone, indicating the presence of opioid binding sites/receptors. The receptor type (i. e. μ, δ- or k-) is at present unknown. [p]Taken together, these data provide evidence that locally administered opiates can act on specific opioid receptors in the synovium to mediate analgesia.

Published
1992

10. Royal academy of medicine in ireland section of biological sciences

Author

W. Bourke, C. O’Connor, M. X. Fitzgerald, T. J. McConnell, A. Kent, E. M. Redmond, A. K. Keenan, E. M. Smyth, R. Shanahan, N. O’Donnell, C. M. O’Connor, V. Kelly, C. Barry-Kinsella, S. C. Sharma, E. Cottrell, R. F. Harrison, B. L. Sheppard, J. Bonnar, O. McNally, B. Hannigan, J. M. Allen, J. Feely, D. Buggy, M. Barry, P. W. N. Keeling, D. G. Weir, A. Breathnach, B. Keogh, T. Cooke, J. Murphy, C. O’Sullivan, M. Walsh, J. Tyrrell, C. Bergin, M. Colgan, D. Moore, D. G. Shanik, A. Southey, E. Costello, B. Jehn, R. Marti, R. Deane, F. Thornton, R. Jaggi, F. Martin, C. Armstrong, D. Mannion, T. Feely, G. Fitzpatrick, P. M. E. McCormack, E. O’Reilly, J. B. Walsh, D. Coakley, J. C. Stinson, C. M. Murphy, J. F. Andrews, G. H. Tomkin, J. P. Howe, D. J. Fogarty, D. Manahan-Vaughan, M. J. Rowan, R. Anwyl, K. D. Thornbury, S. M. Ward, K. M. Sanders, M. Murnin, D. J. S. Guthrie, G. B. Irvine, E. Doyle, C. M. Regan, J. Bannigan, J. Giles, G. I. Adebayo, P. B. Deasy, A. A. M. Omara, M. B. Lambert, T. D. Shields, S. O’Kane, D. Leckey, W. S. Gilmore, B. M. Hannigan, D. McKeogh, A. Bradford, R. G. O’Regan, P. Nolan, F. McEvoy, T. Edgell, P. Webbon, L. Creighton-Kempsford, P. J. Gaffney, M. D. O’Donnell, K. F. McGeeney, E. Breslin, K. Smith, J. R. Docherty, N. Adams, J. Ravey, A. J. Bell, K. K. Tong, J. J. Strain, D. M. Walsh, G. D. Baxter, B. Mokhtar, R. Victory, D. Bergin, C. Cooney, M. Staunton, J. Fitzgerald, J. Gardiner, W. Blunnie, J. Smith, O. Magee, D. Lowe, R. Robinson, J. Magner, P. Eustace, C. J. Martyn, C. M. Cooney, H. Adams, J. B. Lyons, W. P. Blunnie, and D. C. Moriarty

Subjects
business.industry, Section (typography), Medicine, Library science, General Medicine, business, Biological sciences
Published
1992

11. Abstracts

Author

Saiah Michèle, Borgeat Alain, Wilder-Smith Oliver, Orlando R. Hung, Charles E. Hope, Geoffrey Laney, Sara C. Whynot, Thomas J. Coonan, David S. Malloy, S. Patterson, A. Gelb, P. Manninen, D. Strum, B. Glosten, M. J. Spellman, E. I. Eger, R. A. Craen, A. W. Gelb, J. M. Murkin, K. Y. Chong, D. H. Penning, H. El-Behairy, J. F. Brien, J. W. Coh, R. Arellano, J. Correa, L. Fedorko, Z. Liu, J. F. Boylan, A. N. Sandler, H. Nierenberg, P. A. Sheiner, P. D. Greig, G. M. O’Leary, S. J. Teasdale, M. F. X. Glynn, B. A. Orser, L. -Y. Wang, J. F. MacDonald, C. W. Loomis, K. D. Arunachalam, D. Vyas, B. Milne, Daniel Gagnon, Josée Lavoie, Jean-Yves Dupuis, D. R. Miller, R. J. Martineau, D. Greenway, L. Olivaris, K. Hull, R. N. M. Tierney, J. E. Wynands, R. Martineau, B. St-Jean, J. Kitts, D. Miller, P. Lindsay, M. Curran, G. C. Allen, M. L. Crossan, Richard Wise, François Donati, David R. Bevan, J. F. Hardy, J. Desroches, J. Perrault, M. Carrier, D. Robitaille, D. M. Ansley, J. P. O’Connor, J. Dolman, G. E. Townsend, D. Ricci, D. J. Liepert, P. M. Browne, T. Hertz, M. Rooney, R. W. Yip, W. Code, A. A. Phillips, R. F. McLean, J. H. Devitt, E. M. Harrington, R. J. Byrick, P. Y. Wong, D. Wigglesworth, J. C. Kay, L. A. Sinclair, J. P. Koch, K. A. Deemar, G. K. Christakis, S. Belo, P. Angle, D. Cheng, J. Boylan, A. Sandler, C. Feindel, F. Carmichael, P. Boylen, L. G. R. DeLima, H. J. Nathan, M. S. Hynes, M. E. Bourke, G. N. Russell, C. Seyone, F. Chung, Daniel Chartrand, Lucie Roux, S. L. Dain, B. D. Smith, A. C. Webster, D. F. Wigglesworth, D. K. Rose, G. Caskennette, C. Mechetuk, D. John Doyle, Wilfred DeMajo, Frank van den Bosch, Mark Lee, K. M. McClenaghan, C. D. Mazer, R. Preston, E. T. Crosby, D. Kotarba, H. Dudas, R. D. Elliott, J. Enns, P. H. Manninen, J. K. Farrar, David L. Huzyka, L. Philip Lin, Susan Fossey, Brendan T. Finucane, M. Stockwell, S. Lozanoff, S. Lang, J. Hyssen, D. C. Campbell, M. J. Douglas, T. J. G. Pavy, M. L. Flanagan, G. H. McMorland, Colin Bands, Ch. B. Ffaracs, Catherine Lipsett, David Drover, Mark Stafford-Smith, Sarah Stevens, Kate Shields, Michael J. MacSween, J. D. McAllister, P. K. Morley-Forster, A. K. White, M. D. Taylor, H. M. Vandenberghe, D. Knoppert, H. Reimer, P. C. Duke, C. H. Kehler, M. W. Kepron, V. A. Taraska, J. Carstoniu, P. Norman, J. Katz, Medhat Hannallah, C. M. Cooney, J. B. Lyons, A. Hennigan, W. P. Blunnie, D. C. Moriarty, W. B. Dobkowski, F. S. Prato, N. A. Shannon, D. J. Drost, B. Arya, J. M. Wills, D. Bond, P. Morley-Forester, Mullen JB, I. Spahr-Schopfer, J. Lerman, E. Cutz, M. Dolovich, S. Kowalski, B. Ong, D. Bell, T. Ostryzniuk, C. Serrette, T. Wasylak, S. Coke, Takako Tsuda, Takashi Nakagawa, Norifumi Mabuchi, Hiroshi Ando, Osamu Nishida, Takafumi Azami, Hirotada Katsuya, Yukio Goto, N. Searle, M. Roy, null R. R. T., Charles E. Smith, Alfred C. Pinchak, Joan F. Hagen, Donald Hancock, Andrei V. Krassioukov, Lynne C. Weaver, I. R. Sutton, W. A. C. Mutch, J. M. Teskey, I. R. Thomson, M. Rosenbloom, D. Thiessen, S. Teasdale, H. Corbin, M. R. Graham, S. A. Lang, P. Chang, M. Gerard, J. E. Tetzlaff, M. Walsh, H. Yoon, Brian Warriner, Peter Fancourt-Smith, Jim McEwen, Judy Crane, N. H. Badner, R. Bhandari, W. E. Komar, S. Ganapathy, C. B. Warriner, J. P. McCormack, M. Levine, N. Glick, V. W. S. Chan, M. McQuestion, M. Gomez, C. Cruise, D. Evana, D. Shumka, R. J. Smyth, M. Graham, David Halpenny, Gerald V. Goresky, J. Eldon Zaretski, B. Kavanagh, S. Roger, A. Davies, M. Friedlander, M. M. Cohen, P. G. Duncan, W. D. B. Pope, D. Biehl, R. Merchant, W. A. Tweed, Michael J. Tessler, Mark Angle, Simcha Kleiman, B. P. Kavanagh, G. J. Doak, G. Li, R. I. Hall, J. A. Sulliyan, I. Yee, S. Halpern, R. Pittini, C. Huh, G. L. Bryson, R. Gverzdys, C. Perreault, L. Ferland, F. Gobeil, D. Girard, R. Smyth, B. Asokumar, M. Glynn, Sandra Silveira, Jeff Clark, Paul Milgram, W. M. Splinter, H. B. MacNeill, E. A. Ménard, E. J. Rhine, D. J. Roberts, G. M. Gould, G. G. Johnson, Daniel Quance, Saul Wiesel, Jane Easdown, N. Tien Truong, Normand Miller, Nathan Sheiner, L. Welborn, J. Norden, R. Hannallah, L. Broadman, N. Seiden, M. Iwai, R. Iwai, H. Horigome, M. Yamashita, Catherine E. Wood, Kim Klassen, S. Kleinman, S. Yentis, N. Sikich, T. A. Yemen, B. Mascik, W. Nelson, H. Ghantous, J. Gandolfi, Gordon Wood, Mohamed Ali, Kevin Inman, J. M. Karski, J. Carroll, D. Brooks, P. A. Oakley, P. M. Webster, J. Karski, T. Yao, J. Ivanov, P. Young, S. Carson, R. D. Weisel, Richard M. Cooper, David T. Wong, Douglas P. Wagner, William A. Knaus, Charul A. Munshi, John P. Kampine, I. D. Soutter, A. Mathieu, A. Gafni, A. Dauphin, L. Torsher, M. Tierney, H. S. Hopkins, G. J. Baylon, Elizabeth A. Peter, C. P. Bellhouse, Caroline Dore, T. W. Rachwal, D. T. Lanigan, Raymond Yip, J. B. Derdemezi, B. A. Britt, D. E. Withington, F. Reynolds, A. Patrick, W. Man, N. R. Searle, H. Ste-Marie, Mark A. Kostash, Richard Johnston, R. J. Bailey, M. D. Sharpe, R. P. Woda, M. Haug, P. Slugg, J. Lockrem, G. Barnett, B. A. Finegan, M. Robertson, D. Taylor, G. Frost, A. Koshal, Grant E. Rodney, Clayton C. Reichert, Desmond N. O’Regan, Derek Blackstock, David J. Steward, Richard Wenstone, Ellen Harrington, A. Wong, B. Braude, D. Fear, B. Bissonnette, Craig W. Reid, Kathryn A. Hull, S. Yogendran, G. McGuire, V. Chan, E. Hartley, K. Van Kessel, R. Weisel, N. Takla, N. A. Tremblay, F. E. Ralley, J. G. Ramsay, G. R. Robbins, F. C. Salevsky, S. Gandhi, N. Nimphius, Bernard Dionne, Christian Jodoin, Michel Lorange, Alain Lapointe, Geoffrey Hawboldt, G. A. Volgyesi, Guy Tousignant, R. Barnett, and B. Gallant

Subjects
Anesthesiology and Pain Medicine, General Medicine
Published
1992

12. Royal academy of medicine in Ireland section of biological sciences

Author

P. M. Morgan, A. A. J. Adgey, F. Ó Gharbháin, J. M. Bourke, J. F. Roche, J. P. Fraher, S. B. Nolan, J. Gaffney, S. Sunderland, H. H. Dalziel, W. S. Gilmore, I. Graham, J. D. Allen, T. Cook, J. W. Dundee, A. Bradford, K. M. Sanders, J. J. Smith, J. M. O’Donnell, S. M. Ward, K. Smith, John Bonnar, R. K. McKinley, B. M. Hannigan, J. R. Docherty, J. Anderson, M. Maclomhair, D. R. Headon, D. C. Moriarty, J. M. Allen, J. P. Jamison, S. Larkin, C. M. Cooney, S. C. Sharma, F. Buggy, W. J. Hall, A. Savvas, B. L. Sheppard, A. O’Mahony, J. Moore, O. McNally, R. Anwyl, Michael J. Rowan, W. P. Blunnie, J. Kelly, M. Darling, P. J. Hynes, L. J. Creighton-Kempsford, W. P. Abram, V. R. O’Sullivan, Marion Kane, G. O’Sullivan, T. Teoh, M. T. Kane, E. M. Gebruers, S. Connaughton, P. Mantovani, P. L. Chambers, K. M. O’Boyle, K. Robinson, G. A. Hughes, K. D. Thombury, G. C. O’Sullivan, F. Ryan, M. Greally, S. M. Lavelle, S. Wheeler, E. Breslin, D. Manahan-Vaughan, Finian Martin, S. Tait, S. Giafri, C. McGuckin, C. B. Farrell, C. M. McMillan, K. Younger, H. Gallagher, E. O’Donoghue, J. K. Collins, E. Tarelli, J. Lyons, D. Westfall, M. Boland, M. O’Donoghue, R. Deane, A. W. Baird, D. J. Cochrane, N. G. McHale, M. Ryan, D. Conlon, J. Feely, and A. Harris

Subjects
business.industry, Section (typography), engineering, Library science, Medicine, General Medicine, Cork, engineering.material, business, Biological sciences
Published
1992

13. Royal Academy of Medicine in Ireland Section of Biological Sciences Proceedings of Winter Meeting at Earlsfort Terrace, University College Dublin, 4th January 1991

Author

D. Phelan, Angela M. Carragher, P. S. Collier, James A. Houghton, F. Finian Martin, D. P. Nicholls, D. Cottell, C. H. Homer, John Feely, Roger Anwyl, B. Mokhtar, L. Penney, D. C. Moriarty, F. Ryan, M. Reilly, Noreen Gleeson, R. Gonsalves, E. O’Leary, G. Fitzpatrick, R. P. Barrett, J. Mahon, C. McCaul, Patrick J. Gaffney, S. F. Craig, John Bannigan, J. R. P. Gibbons, B. J. Chambers, P. S. Gascoine, Maura Grealy, J. Bourke, D. Doherty, James Bernard Walsh, Catherine A. Martin, M. Kelly, P. O’Keane, T. P. Crotty, G. D. Baxter, J.P.H. Fee, B. L. Sheppard, N. McDonald, S. C. Sharma, E. McGuinness, C. Doolan, M. B. Lambert, W. J. Hall, Marie Jordan, L. Keegan, M. O’Brien, John Kelly, D. O’Mahony, Aidan Bradford, A. J. McShane, D. Mannion, R.S.J. Clarke, W. P. Blunnie, W. P. Abram, J. M. Allen, P. M. Tymkewycz, J. A. McGuigan, Michael J. Rowan, Anne-Marie Nugent, John Bonnar, T. Grimm, C. Longstaff, J. A. Parmo, C. Boyle, Elinor Arbuthnott, J. M. O’Donnell, J. Quigley, J. Ravey, F. O’Donovan, Brian E. Leonard, A. J. Bell, Deirdre Cooney, L. J. Creighton-Kempsford, Elizabeth F. Hall, K. Prasanna, F. Kirby, K. McGrath, D. Coakley, J. B. Pring, A. A. M. Omara, M. S. McKinney, John W. Dundee, C. M. McMillan, C. M. Cooney, A. K. Keenan, Anne Burke-Gaffney, R. Chan, K. Mulpeter, Lucy A. Norris, E. McKone, P. B. Deasy, and N. W. Klein

Subjects
geography, geography.geographical_feature_category, Terrace (geology), business.industry, Section (archaeology), Medicine, General Medicine, business, Biological sciences, Archaeology
Published
1991

14. Intraperitoneal pethidine versus intramuscular pethidine for the relief of pain after laparoscopic cholecystectomy: randomized trial

Author

D. C. Moriarty, Deirdre M O’Hanlon, Gerry McEntee, Jackie Ragheb, Sallyann Colbert, and Frank Chambers

Subjects
Adult, Male, medicine.medical_specialty, Meperidine, Nausea, medicine.medical_treatment, Injections, Intramuscular, Drug Administration Schedule, Statistics, Nonparametric, Cholelithiasis, medicine, Humans, Pain Measurement, Probability, Bupivacaine, Analysis of Variance, Pain, Postoperative, Dose-Response Relationship, Drug, business.industry, Middle Aged, Surgery, Pethidine, Analgesics, Opioid, Treatment Outcome, Cholecystectomy, Laparoscopic, Anesthesia, Ambulatory, Vomiting, Intractable pain, Cholecystectomy, Female, medicine.symptom, business, Injections, Intraperitoneal, medicine.drug, Abdominal surgery, Follow-Up Studies
Abstract

Laparoscopic cholecystectomy is widely used and may be performed as an ambulatory procedure. We undertook a randomized comparison of the benefits of intraperitoneal pethidine compared with intramuscular pethidine for postoperative analgesia following laparoscopic cholecystectomy. A series of 100 consecutive American Society of Anesthesiologists (ASA) I or II patients were randomly assigned to intramuscular pethidine (54 patients) or intraperitoneal pethidine (46 patients). Each was combined with intraperitoneal bupivacaine. The primary endpoints were the pain and nausea scores at intervals after operation. All recruited patients completed the study. Pain scores at rest and upon movement were significantly lower in the group receiving the intraperitoneal pethidine at each of the time periods examined (pain at rest at 4 hours: 1.6 +/- 0.8 vs. 2.4 +/- 0.9 cm; p0.001; pain upon movement at 4 hours: 2.1 +/- 0.9 vs. 3.1 +/- 1.2 cm; p0.001). The total dose of pethidine administered via patient-controlled analgesia (PCA) during the first 24 hours after surgery was also significantly lower in this group (total dose 50.9 +/- 3.9 vs. 55.9 +/- 4.4 mg; p0.001). There were no significant differences in the respiratory rate at any of the time periods. Intraperitoneal pethidine analgesia was superior to an equivalent dose of intramuscular pethidine for the relief of postoperative pain in patients undergoing laparoscopic cholecystectomy. This was achieved at the expense of increased nausea but no significant increase in vomiting. The accessibility of this route of analgesia administration has implications for patients undergoing laparoscopic procedures, particularly with the recent trend toward increased use of ambulatory techniques.

Published
2002

15. Pulmonary embolism following tonsillectomy

Author

D. C. Moriarty, A. W. Blayney, Peter D. Lacy, and Irene E. Leonard

Subjects
Adult, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Tonsillitis, Tonsillar Neoplasms, Thrombophilia, Postoperative Complications, medicine, Coagulopathy, Humans, Tonsillectomy, business.industry, Heparin, Lymphoma, Non-Hodgkin, Respiratory disease, Anticoagulant, Anticoagulants, General Medicine, medicine.disease, Pulmonary embolism, Surgery, Otorhinolaryngology, Acute Disease, Female, business, Complication, Pulmonary Embolism
Abstract

Acute post-operative pulmonary embolism is a serious potentially life-threatening complication which is not anticipated in young patients undergoing non-major surgery. We report a case in which a 32-year-old previously healthy woman developed a major pulmonary embolism following tonsillectomy. Subsequent investigations revealed the presence of an occult malignancy. This case highlights the role of paraneoplastic hypercoagulable states in the aetiology of venous thromboembolism and the importance of thromboprophylaxis in the presence of confirmed or suspected malignancy. To our knowledge no case of major pulmonary embolism occurring after tonsillectomy has been previously reported.

Published
2001

16. An assessment of the value of intraperitoneal meperidine for analgesia postlaparoscopic tubal ligation

Author

Deirdre M. O’Hanlon, William P. Blunnie, D. C. Moriarty, Sallyann T. Colbert, Kirean Moran, and Frank Chambers

Subjects
Adult, medicine.medical_specialty, Meperidine, medicine.drug_class, Sterilization, Tubal, medicine.medical_treatment, Analgesic, Route of administration, medicine, Humans, Anesthetics, Local, Laparoscopy, Ligature, Pain Measurement, Bupivacaine, Tubal ligation, Pain, Postoperative, medicine.diagnostic_test, Local anesthetic, business.industry, Surgery, Pethidine, Analgesics, Opioid, Anesthesiology and Pain Medicine, Anesthesia, Female, Analgesia, business, Injections, Intraperitoneal, medicine.drug
Abstract

UNLABELLED Patients undergoing laparoscopic procedures may experience postoperative pain. The intraperitoneal (IP) administration of drugs is controversial but has proven effective in some studies for the relief of postoperative pain. However, some investigators have not been able to confirm the analgesic efficacy of IP local anesthetics. The administration of IP opioids for the relief of postoperative pain has received little attention. At the end of laparoscopic tubal ligation, 100 patients received 80 mL of 0.125% bupivacaine with 1:200,000 epinephrine IP and 50 mg of meperidine either IP or IM. Postoperative pain scores were measured at rest and with movement. Pain scores were significantly lower in the group receiving the IP meperidine both at rest (P: < 0.01) and with movement (P: < 0.05). We conclude that the combination of intraperitoneal bupivacaine and intraperitoneal meperidine was better than the combination of IP bupivacaine and IM meperidine for postoperative analgesia in patients undergoing laparoscopic tubal ligation. IMPLICATIONS The combination of bupivacaine and meperidine delivered to the intraperitoneal cavity proved superior to equivalent doses of intraperitoneal bupivacaine and IM meperidine for postoperative pain relief in patients undergoing laparoscopic tubal ligation. Intraperitoneal delivery of analgesia proved effective in this study and merits further study and more widespread use.

Published
2000

17. The effect of rectal diclofenac on pruritus in patients receiving intrathecal morphine

Author

S, Colbert, D M, O'Hanlon, S, Galvin, F, Chambers, and D C, Moriarty

Subjects
Male, Pain, Postoperative, Diclofenac, Morphine, Pruritus, Anti-Inflammatory Agents, Non-Steroidal, Middle Aged, Drug Administration Schedule, Analgesics, Opioid, Administration, Rectal, Abdomen, Humans, Female, Prospective Studies, Aged
Abstract

In this prospective randomised study, pruritus and pain were evaluated in patients undergoing abdominal surgery in which intrathecal morphine was administered. Each patient received intrathecal morphine 0.3 mg prior to induction, followed by a standard anaesthetic. The patients were randomly allocated to one of two groups. One group received 100 mg of rectal diclofenac immediately post-induction. Patients receiving diclofenac had significantly lower pruritus scores at 30 min (p = 0.0076), 2, 4, 8 and 24 h postoperatively, as well as significantly reduced pain scores at each time point (p0.0001 at each study interval). Morphine consumption in the first 24 h was also significantly lower in this group. In conclusion, rectal administration of diclofenac significantly reduces the incidence and severity of postoperative pruritus. It also significantly reduces pain and further analgesic requirements postoperatively.

Published
1999

18. The effect of intravenous tenoxicam on pruritus in patients receiving epidural fentanyl

Author

Deirdre M O’Hanlon, Frank Chambers, D. C. Moriarty, and Sallyann Colbert

Subjects
Male, medicine.medical_specialty, Analgesic, Fentanyl, Piroxicam, Bolus (medicine), Tenoxicam, Abdomen, Medicine, Humans, Cyclooxygenase Inhibitors, Prospective Studies, Prospective cohort study, Aged, Pain, Postoperative, business.industry, Pruritus, Anti-Inflammatory Agents, Non-Steroidal, Middle Aged, Surgery, Pethidine, Analgesia, Epidural, Analgesics, Opioid, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Anesthesia, Injections, Intravenous, Female, business, medicine.drug, Abdominal surgery
Abstract

In this prospective randomised study, pruritus and pain were evaluated in patients undergoing abdominal surgery during which epidural fentanyl was administered. All patients had an epidural catheter inserted at the time of surgery. Epidural fentanyl 100 micrograms was administered intra-operatively and infused at a concentration of 2 micrograms.ml-1 for 48 h postoperatively. All patients received a standard anaesthetic and, in addition, the study group had a 20 mg bolus of tenoxicam intravenously, intra-operatively. Patients receiving tenoxicam demonstrated significantly lower pruritus and pain scores at 30 min, 2, 4, 8 and 24 h postoperatively as well as reduced pethidine requirements for breakthrough pain in the first 24 h. In conclusion, tenoxicam 20 mg significantly reduces the incidence and severity of postoperative pruritus in patients who received peri-operative epidural fentanyl. In addition, it significantly reduces pain and further analgesic requirements postoperatively.

Published
1999

19. Anaesthetic depth at induction. An evaluation using clinical eye signs and EEG polysomnography

Author

C, Power, C, Crowe, P, Higgins, and D C, Moriarty

Subjects
Adult, Methyl Ethers, Adolescent, Eye Movements, Polysomnography, Electroencephalography, Sevoflurane, Evaluation Studies as Topic, Anesthetics, Inhalation, Reaction Time, Humans, Female, Sleep Stages, Tonsillectomy
Abstract

We describe the stages of non-REM sleep induced by anaesthesia with sevoflurane 8% in oxygen and relate these stages to clinical eye positions. We explored John Snow's observation (1847) that 'when voluntary movement ceases, with the eyes fixed in an upward gaze during the gas induction of anaesthesia, the patient is protected against the risk of mental suffering' (awareness). Unpremedicated ASA 1 patients undergoing elective tonsillectomy were studied using EEG polysomnographic principles and clinical eye movement tracking. The results expressed as median and range were: latency to stage 1 sleep 4.5 min [2.5-7.5], stage 2 sleep 5 min [3.5-8.5], stage 3 sleep 5.5 min [4-12] and stage 4 sleep 6 min [4.5-15.5]. Eye position 5, the point of no further eye movement, was reached after 9 min [5.5-18.5]. This was significantly longer than the time taken to reach the stage 4 sleep EEG, p0.01, supporting Snow's observation and encouraging investigation into eye movement tracking technology as a potential monitor of anaesthetic depth.

Published
1998

20. The laryngeal mask airway reduces blood flow in the common carotid artery bulb

Author

Rory Page, Deirdre M O’Hanlon, F. Flanagan, D. C. Moriarty, and Sallyann Colbert

Subjects
Larynx, Adult, Carotid Artery Diseases, Male, Arteriosclerosis, Carotid Artery, Common, Surface Properties, Hemodynamics, Blood Pressure, Laryngeal Masks, Laryngeal mask airway, medicine.artery, medicine, Humans, Common carotid artery, Aged, business.industry, Air, Carotid sinus, Age Factors, General Medicine, Blood flow, Equipment Design, Middle Aged, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Blood pressure, Carotid Sinus, Elective Surgical Procedures, Regional Blood Flow, Ultrasonography, Doppler, Pulsed, Anesthesia, Cuff, Female, business, Blood Flow Velocity
Abstract

The introduction of the laryngeal mask airway (LMA) has had a major impact on anaesthetic practice in the last ten years. Previous authors have demonstrated pressures equivalent to mean arterial blood pressure within the cuff of the LMA. This study examined the effects of cuff inflation on the cross sectional area, flow and velocity of blood flow at the level of the carotid sinus. Seventeen patients scheduled to have LMAs inserted as part of routine anaesthetic management were recruited into the study. Measurements of the common carotid artery bulb area, peak velocity and blood flow were performed upon LMA cuff inflation and deflation using a 5 MHz pulse wave Doppler probe. Deflation of the cuff resulted in an increase in the cross sectional area (from 0.58 ± 0.05 to 0.64 ± 0.04 cm2;P < 0.005), an increase in blood flow (from 65.6 ± 5.6 to 73.9 ± 5.6 cm3· sec−1; P < 0.05) and a slight but non significant increase in velocity of blood flow. This study demonstrates that inflation of the cuff on the LMA results in a decrease in carotid bulb cross sectional area which results in a decrease in blood flow.

Published
1998

21. Anaesthesia for non-cardiac surgery in the post-cardiac transplant patient

Author

R. MacSullivan, J. B. Lyons, D. C. Moriarty, and F. A. Chambers

Subjects
medicine.medical_specialty, POST-CARDIAC TRANSPLANT, medicine.medical_treatment, Guidelines as Topic, Risk Assessment, Quality of life, medicine, Humans, Anesthesia, Intensive care medicine, Heart transplants, Heart transplantation, business.industry, Clinical course, Heart, General Medicine, medicine.disease, Prognosis, Abdominal aortic aneurysm, Non cardiac surgery, Surgical Procedures, Operative, Heart Transplantation, business, Noncardiac surgery, Immunosuppressive Agents
Abstract

As survival and quality of life continue to improve for cardiac transplant recipients, the number of patients with functioning heart transplants who present for surgery continues to increase. The conditions for which surgery may be required, the specific problems relating to anaesthesia and the necessary measures which should be taken to ensure an uncomplicated clinical course are discussed. A clear understanding of the physiology and pharmacology of the denervated heart is essential for these patients to undergo safely anaesthesia and surgery.

Published
1995

22. Mechanical ventilation in the elderly

Author

G, O'Leary and D C, Moriarty

Subjects
Aged, 80 and over, Critical Care, Age Factors, Humans, Respiration, Artificial, Aged
Published
1994

24. Inaugural national scientific medical meeting

Author

P. Noonan Walsh, C. Conliffe, A. S. Abdulkadir, P. Kelehan, R. Conroy, M. Foley, P. Lenehan, J. F. Murphy, J. Stronge, B. Cantwell, C. Wright, M. Millward, M. Carpenter, T. Lennard, R. Wilson, C. Home, A. R. Corbett, G. O’Sullivan, J. K. Collins, M. Doran, E. W. M. McDermott, P. Mercer, P. Smyth, N. J. O’Higgins, M. J. Duffy, D. Reilly, E. McDermott, C. Faul, J. J. Fennelly, N. O’Higgins, S. Lowry, H. Russell, R. Atkinson, I. Hickey, F. O’Brien, A. O’Mahony, M. O’Donoghue, M. Pomeroy, E. S. Prosser, F. Barker, M. Casey, K. Carroll, M. Davis, G. Duffy, R. O’Kennedy, P. P. A. Smyth, D. O’Carroll, A. M. Hetherton, E. Coveney, V. McAlister, M. J. Murray, D. J. Brayden, A. O’Hora, J. Street, J. O’Leary, A. M. Pollock, M. Crowley, I. Healy, J. Murphy, R. Landers, L. Burke, D. O’Brien, P. Annis, J. Hogan, W. Kealy, F. A. Lewis, C. T. Doyle, M. Callaghan, A. Whelan, C. Feighery, B. Bresnihan, D. Kelleher, G. Reams, A. Murphy, N. Hall, E. B. Casey, D. Mulherin, E. Doherty, G. Yanni, E. Wallace, J. Jackson, M. Bennett, O. Tighe, H. Mulcahy, D. O’Donoghue, D. T. Croke, R. J. Cahill, S. Beattie, H. Hamilton, C. O’Morain, B. Corridan, R. A. Collins, C. A. O’Morain, E. Fitzgerald, J. M. Gilvarry, M. Leader, J. F. Fielding, B. T. Johnson, S. A. Lewis, A. H. G. Love, B. T. Johnston, J. S. A. Collins, R. J. McFarland, P. W. Johnston, B. J. Collins, C. M. Kilgallen, G. M. Murphy, G. M. Markey, J. A. McCormack, R. C. Curry, T. C. M. Morris, H. D. Alexander, S. Edgar, M. Treacy, M. A. O’Connell, D. G. Weir, J. Sheehan, G. O’Loughlin, O. Traynor, N. Walsh, H. X. Xia, M. A. Daw, C. T. Keane, C. Dupont, G. Gibson, E. McGinnity, J. Walshe, M. Carmody, J. Donohoe, P. McGrath, R. O’Moore, E. Kieran, S. Rogers, K. E. McKenna, M. Walsh, E. A. Bingham, A. E. Hughes, N. C. Nevin, D. J. Todd, C. F. Stanford, M. E. Callender, D. Burrows, D. G. Paige, G. E. Allen, D. P. O’Brien, D. B. Gough, C. Phelan, H. F. Given, S. Zia Kamal, S. Kehoe, S. Coldicott, D. Luesley, K. Ward, H. F. MacDonnell, S. Mullins, I. Gordon, L. A. Norris, M. Devitt, J. Bonnar, S. C. Sharma, B. L. Sheppard, R. Fitzsimons, S. Kingston, M. Garvey, H. M. C. V. Hoey, J. F. T. Glasgow, R. Moore, P. H. Robinson, E. Murphy, J. F. A. Murphy, A. E. Wood, P. Sweeney, M. Neligan, D. MacLeod, G. Cunnane, P. Kelly, P. Corcoran, L. Clancy, R. M. Drury, M. I. Drury, D. Powell, R. G. R. Firth, T. Jones, B. F. Ferris, W. O’Flynn, J. O’Donnell, S. M. Kingston, F. Cunningham, G. M. E. Hinds, D. R. McCluskey, F. Howell, M. O’Mahony, J. Devlin, O. O’Reilly, C. Buttanshaw, S. Jennings, E. R. Keane, C. Foley-Nolan, F. M. Ryan, M. Taylor, R. A. Lyons, F. O’Kelly, J. Mason, D. Carroll, K. Doherty, M. Flynn, R. O’Dwyer, J. J. Gilmartin, C. F. McCarthy, C. Armstrong, D. Mannion, T. Feely, G. Fitzpatrick, C. M. Cooney, J. Chin Aleong, R. Rooney, J. Lyons, D. M. Phelan, G. P. Joshi, S. M. McCarroll, W. P. Blunnie, T. M. O’Brien, D. C. Moriarty, J. Brangan, C. P. Kelly, P. Kenny, H. Gallagher, E. McGovern, D. Luke, D. Lowe, T. Rice, D. Phelan, J. B. Lyons, F. M. Lyons, D. M. McCoy, J. McGinley, J. Hurley, P. McDonagh, J. J. Crowley, S. M. Donnelly, M. Tobin, O. Fitzgerald, B. J. Maurer, P. J. Quigley, G. King, E. B. Duly, T. R. Trinick, D. Boyle, G. B. Wisdom, F. Geoghegan, P. B. Collins, C. Goss, K. Younger, P. Mathias, I. Graham, S. W. MacGowan, P. Sidhu, D. J. McEneaney, D. J. Cochrane, A. A. J. Adgey, J. M. Anderson, J. Moriarty, C. Fahy, A. Lavender, L. Lynch, C. McGovern, A. M. Nugent, D. Neely, I. Young, I. McDowell, M. O’Kane, D. P. Nicholls, D. McEneaney, D. P. Nichols, N. P. S. Campbell, G. C. Campbell, M. I. Halliday, A. F. O’Donnell, M. Lonergan, T. Ahearne, J. O’Neill, T. V. Keaveny, D. Ramsbottom, D. Boucher-Hayes, R. Sheahan, M. T. Garadaha, D. Kidney, P. Freyne, G. Gearty, P. Crean, H. P. Singh, M. Hargrove, K. Subareddy, J. P. Hurley, W. O’Rourke, C. O’Connor, M. X. FitzGerald, T. J. McDonnell, R. Chan, J. Stinson, L. Hemeryck, J. Feely, M. P. Chopra, A. Sivner, S. M. Sadiq, E. Abernathy, L. Plant, C. P. Bredin, P. Hickey, G. Slevin, K. McCrory, M. Long, P. Conlon, F. Walker, P. Fitzgerald, S. J. O’Neill, C. M. O’Connor, C. Quigley, S. Donnelly, A. Southey, E. Healy, F. Mulcahy, D. J. Lyons, J. Keating, C. O’Mahony, D. Roy, A. G. Shattock, I. B. Hillary, A. Waiz, R. Hossain, B. Chakraborthy, L. P. Clancy, L. O’Reilly, C. Byrne, E. Costello, E. O’Shaughnessy, B. Cryan, J. Farrell, J. J. Walshe, G. J. Mellotte, C. A. Ho, S. H. Morgan, M. R. Bending, and J. Bonner

Subjects
Medical education, business.industry, Medicine, General Medicine, business, Article
Published
1993

26. Correspondence

Author

D. C. Moriarty and Sallyann Colbert

Subjects
Anesthesiology and Pain Medicine, business.industry, Forensic engineering, Medicine, Reinforced endotracheal tube, business, Hazard
Published
1999

30. Erratum

Author

Saiah Michèle, Borgeat Alain, Wilder-Smith Oliver, Orlando R. Hung, Charles E. Hope, Geoffrey Laney, Sara C. Whynot, Thomas J. Coonan, David S. Malloy, S. Patterson, A. Gelb, P. Manninen, D. Strum, B. Glosten, M. J. Spellman, E. I. Eger, R. A. Craen, A. W. Gelb, J. M. Murkin, K. Y. Chong, D. H. Penning, H. El-Behairy, J. F. Brien, J. W. Coh, R. Arellano, J. Correa, L. Fedorko, Z. Liu, J. F. Boylan, A. N. Sandler, H. Nierenberg, P. A. Sheiner, P. D. Greig, G. M. O’Leary, S. J. Teasdale, M. F. X. Glynn, B. A. Orser, L. -Y. Wang, J. F. MacDonald, C. W. Loomis, K. D. Arunachalam, D. Vyas, B. Milne, Daniel Gagnon, Josée Lavoie, Jean-Yves Dupuis, D. R. Miller, R. J. Martineau, D. Greenway, L. Olivaris, K. Hull, R. N. M. Tierney, J. E. Wynands, R. Martineau, B. St-Jean, J. Kitts, D. Miller, P. Lindsay, M. Curran, G. C. Allen, M. L. Crossan, Richard Wise, François Donati, David R. Bevan, J. F. Hardy, J. Desroches, J. Perrault, M. Carrier, D. Robitaille, D. M. Ansley, J. P. O’Connor, J. Dolman, G. E. Townsend, D. Ricci, D. J. Liepert, P. M. Browne, T. Hertz, M. Rooney, R. W. Yip, W. Code, A. A. Phillips, R. F. McLean, J. H. Devitt, E. M. Harrington, R. J. Byrick, P. Y. Wong, D. Wigglesworth, J. C. Kay, L. A. Sinclair, J. P. Koch, K. A. Deemar, G. K. Christakis, S. Belo, P. Angle, D. Cheng, J. Boylan, A. Sandler, C. Feindel, F. Carmichael, P. Boylen, L. G. R. DeLima, H. J. Nathan, M. S. Hynes, M. E. Bourke, G. N. Russell, C. Seyone, F. Chung, Daniel Chartrand, Lucie Roux, S. L. Dain, B. D. Smith, A. C. Webster, D. F. Wigglesworth, D. K. Rose, G. Caskennette, C. Mechetuk, D. John Doyle, Wilfred DeMajo, Frank Bosch, Mark Lee, K. M. McClenaghan, C. D. Mazer, R. Preston, E. T. Crosby, D. Kotarba, H. Dudas, R. D. Elliott, J. Enns, P. H. Manninen, J. K. Farrar, David L. Huzyka, L. Philip Lin, Susan Fossey, Brendan T. Finucane, M. Stockwell, S. Lozanoff, S. Lang, J. Hyssen, D. C. Campbell, M. J. Douglas, T. J. G. Pavy, M. L. Flanagan, G. H. McMorland, Colin Bands, Ch. B. Ffaracs, Catherine Lipsett, David Drover, Mark Stafford-Smith, Sarah Stevens, Kate Shields, Michael J. MacSween, J. D. McAllister, P. K. Morley-Forster, A. K. White, M. D. Taylor, H. M. Vandenberghe, D. Knoppert, H. Reimer, P. C. Duke, C. H. Kehler, M. W. Kepron, V. A. Taraska, J. Carstoniu, P. Norman, J. Katz, Medhat Hannallah, C. M. Cooney, J. B. Lyons, A. Hennigan, W. P. Blunnie, D. C. Moriarty, W. B. Dobkowski, F. S. Prato, N. A. Shannon, D. J. Drost, B. Arya, J. M. Wills, D. Bond, P. Morley-Forester, Mullen JB, I. Spahr-Schopfer, J. Lerman, E. Cutz, M. Dolovich, S. Kowalski, B. Ong, D. Bell, T. Ostryzniuk, C. Serrette, T. Wasylak, S. Coke, Takako Tsuda, Takashi Nakagawa, Norifumi Mabuchi, Hiroshi Ando, Osamu Nishida, Takafumi Azami, Hirotada Katsuya, Yukio Goto, N. Searle, M. Roy, null R. R. T., Charles E. Smith, Alfred C. Pinchak, Joan F. Hagen, Donald Hancock, Andrei V. Krassioukov, Lynne C. Weaver, I. R. Sutton, W. A. C. Mutch, J. M. Teskey, I. R. Thomson, M. Rosenbloom, D. Thiessen, S. Teasdale, H. Corbin, M. R. Graham, S. A. Lang, P. Chang, M. Gerard, J. E. Tetzlaff, M. Walsh, H. Yoon, Brian Warriner, Peter Fancourt-Smith, Jim McEwen, Judy Crane, N. H. Badner, R. Bhandari, W. E. Komar, S. Ganapathy, C. B. Warriner, J. P. McCormack, M. Levine, N. Glick, V. W. S. Chan, M. McQuestion, M. Gomez, C. Cruise, D. Evana, D. Shumka, R. J. Smyth, M. Graham, David Halpenny, Gerald V. Goresky, J. Eldon Zaretski, B. Kavanagh, S. Roger, A. Davies, M. Friedlander, M. M. Cohen, P. G. Duncan, W. D. B. Pope, D. Biehl, R. Merchant, W. A. Tweed, Michael J. Tessler, Mark Angle, Simcha Kleiman, B. P. Kavanagh, G. J. Doak, G. Li, R. I. Hall, J. A. Sulliyan, I. Yee, S. Halpern, R. Pittini, C. Huh, G. L. Bryson, R. Gverzdys, C. Perreault, L. Ferland, F. Gobeil, D. Girard, R. Smyth, B. Asokumar, M. Glynn, Sandra Silveira, Jeff Clark, Paul Milgram, W. M. Splinter, H. B. MacNeill, E. A. Ménard, E. J. Rhine, D. J. Roberts, G. M. Gould, G. G. Johnson, Daniel Quance, Saul Wiesel, Jane Easdown, N. Tien Truong, Normand Miller, Nathan Sheiner, L. Welborn, J. Norden, R. Hannallah, L. Broadman, N. Seiden, M. Iwai, R. Iwai, H. Horigome, M. Yamashita, Catherine E. Wood, Kim Klassen, S. Kleinman, S. Yentis, N. Sikich, T. A. Yemen, B. Mascik, W. Nelson, H. Ghantous, J. Gandolfi, Gordon Wood, Mohamed Ali, Kevin Inman, J. M. Karski, J. Carroll, D. Brooks, P. A. Oakley, P. M. Webster, J. Karski, T. Yao, J. Ivanov, P. Young, S. Carson, R. D. Weisel, Richard M. Cooper, David T. Wong, Douglas P. Wagner, William A. Knaus, Charul A. Munshi, John P. Kampine, I. D. Soutter, A. Mathieu, A. Gafni, A. Dauphin, L. Torsher, M. Tierney, H. S. Hopkins, G. J. Baylon, Elizabeth A. Peter, C. P. Bellhouse, Caroline Dore, T. W. Rachwal, D. T. Lanigan, Raymond Yip, J. B. Derdemezi, B. A. Britt, D. E. Withington, F. Reynolds, A. Patrick, W. Man, N. R. Searle, H. Ste-Marie, Mark A. Kostash, Richard Johnston, R. J. Bailey, M. D. Sharpe, R. P. Woda, M. Haug, P. Slugg, J. Lockrem, G. Barnett, B. A. Finegan, M. Robertson, D. Taylor, G. Frost, A. Koshal, Grant E. Rodney, Clayton C. Reichert, Desmond N. O’Regan, Derek Blackstock, David J. Steward, Richard Wenstone, Ellen Harrington, A. Wong, B. Braude, D. Fear, B. Bissonnette, Craig W. Reid, Kathryn A. Hull, S. Yogendran, G. McGuire, V. Chan, E. Hartley, K. Kessel, R. Weisel, N. Takla, N. A. Tremblay, F. E. Ralley, J. G. Ramsay, G. R. Robbins, F. C. Salevsky, S. Gandhi, N. Nimphius, Bernard Dionne, Christian Jodoin, Michel Lorange, Alain Lapointe, Geoffrey Hawboldt, G. A. Volgyesi, Guy Tousignant, R. Barnett, and B. Gallant

Subjects
Anesthesiology and Pain Medicine, General Medicine
Published
1992

31. Book Reviews

Author

D. C. Moriarty and C. S. Breathnach

Subjects
General Medicine
Published
1992

32. Book reviews

Author

D. C. Moriarty and C. S. Breathnach

Subjects
General Medicine
Published
1992

33. Abstracts

Author

S. G. Bertram, J. P. Koch, J. D. Dubbin, R. Maggisano, R. N. McKenzie, I. R. Thomson, R. J. Hudson, M. Torchia, M. Rosenbloom, J. E. Wynands, D. M. Ansley, J. M. Bent, J. G. Ramsay, D. G. Whalley, F. E. Ralley, F. Carli, K. G. Smedstad, D. H. Morison, S. M. McCanoll, P. Cartwright, S. K. Weeks, F. Donati, M. C. Michoud, R. Amyot, A. Jeanneret-Grosjean, J. Couture, N. J. McDonald, P. Lavelle, R. P. Harpin, W. N. Gallacher, J. P. Baker, J. B. Kitts, L. J. Veilleux, R. McBurney, R. Martineau, B. Bissonnette, J. Lerman, G. Lim, D. C. Chung, G. Plourde, J. F. Hardy, P. P. Bany, L. Tardif, P. Labrecque, D. P. Archer, J. Tyler, E. Meyer, D. Trop, S. C. Brown, A. M. Lam, P. H. Manninen, J. M. Katz, M. Abou-Madi, N. Abou-Madi, T. E. Woodcock, J. M. Murkin, J. K. Farrar, W. A. Tweed, G. Guiraudon, F. N. McKenzie, S. G. Nadeau, J. R. Robblee, F. J. Mensink, R. Kozody, C. H. Kehler, J. G. Wade, D. R. Bevan, M. Baxter, J. C. Bevan, S. M. McCarroll, C. Antzaka, D. McCready, J. Lahoud, D. J. O’Brien, D. C. Moriarty, C. E. Hope, B. A. Liberman, R. Skala, A. Lam, A. Gelb, A. W. Gelb, G. K. Steinberg, A. Rassi Neto, M. Bellefleur, J. Layon, T. J. Gallagher, L. S. Berman, D. D. Davidson, P. C. Duke, J. Parrott, R. J. Palahniuk, A. J. Cunningham, W. Casey, V. Hannon, C. Litak, D. Ansley, H. Fullerton, A. R. Ripley, M. H. Sami, L. Harrison, G. R. Robbins, H. A. Fullerton, H. J. Nathan, C. C. Arvieux, P. Foëx, W. A. Ryder, L. A. Jones, E. A. Moffitt, A. J. Mclntyre, D. D. Imrie, C. E. Kinley, J. A. Sullivan, D. A. Murphy, J. E. Cannon, A. Morris, R. Robbins, J. R. Ramsay, G. Blaise, J. C. Sill, M. Nugent, P. M. Vanhoutte, C. A. Moote, M. I. Skinner, D. M. Grace, R. L. Knill, R. G. Johnston, B. J. Anderson, T. W. Noseworthy, A. Shustack, R. B. Forbes, V. Kumar, F. A. Mitros, G. M. Johnson, P. Coleman, S. Roth, M. S. P. Macnab, J. Fuller, S. Karlik, C. Diamond, R. S. Hannallah, R. I. Patel, M. B. Ehrenpreis, I. E. Soliman, M. Cunliffe, B. A. Britt, J. E. Kapsten, L. M. Broadman, W. C. Norrie, G. L. Mundy, A. B. Belman, K. D. Anderson, P. C. Guzetta, T. D. Sharpe, G. V. Goresky, M. A. Sabourin, B. Ahuja, S. Eustis, D. Smith, S. Lenis, D. Archer, P. Ravussin, S. Bélisle, J. F. Saint-Germain, F. Chung, R. Meier, M. Lebrun, S. Dubé, C. Côté, R. J. Byrick, G. Howie, J. C. Kay, J. P. Waddell, and B. Mullen

Subjects
Anesthesiology and Pain Medicine, General Medicine
Published
1986

34. Royay academy of medicine in Ireland section of biological sciences

Author

W. P. Blunnie, I. Pratt, Anthony G. Molloy, Ciaran Bolger, C. M. Wilson, P. B. Deasy, M. M. Brady, R. G. Luckwill, N. W. Chestnutt, F. R. Comerford, Mark G. Davies, M. S. O'mahony, A. Y. Yasear, William F. M. Wallace, R. S. J. Clarke, M. Garrett, B. Donne, M. Neligan, J. Ehrenfeld, J. P. Jamison, J. F. Andrews, D. F. Murphy, A. C. B. Hooper, E. M. Thompson, L. Drudy, M. Houlden, J. Manning, Elinor Arbuthnott, H. Hourihan, Caroline G. Bullock, Roger Anwyl, John Bannigan, M. G. O’Regan, M. K. Hammad, R. E. Moore, Brian J. Harvey, R. Hill, D. Tynan, Brian E. Leonard, L. Daly, F. P. Robinson, J. F. Jackson, I. M. Bali, Declan Mulkeen, John W. Dundee, W. Holmes, K. M.P. Carroll, K. Horgan, B. L. Sheppard, P. G. Loughran, L. Wai-Ling, John Bonnar, F. Colreavy, R. J. T. Carlisle, S. C. Sharma, P. L. Chambers, J. Sheehan, D. C. Moriarty, C. J. Dockeray, A. Ireland, N. J. Halliday, A. K. Keenan, A. J. McShane, P. Elliott, C. Power, Michael J. Rowan, Clare O'Connor, J. L. Waddington, S. Hanley, D. Gilroy, B. W. Otridge, K. W. Harper, Muiris X. Fitzgerald, J. M. Moohan, A. J. Humphreys, and G. O’Dowd

Subjects
business.industry, Thursday, Section (typography), Library science, Medicine, General Medicine, business, Biological sciences
Published
1985

35. Royal Academy Of Medicine In Ireland Section Of Biological Sciences

Author

J. F. Andrews, D. Cabot, M. E. Jakobson, S. McBennett, Clare Fallon, David Orr, Lisa Collins, Fidelma Fitzpatrick, Moira O’Brien, W. Vincent Young, Siobhan Brown, Fiona Lyons, John Donoghue, Lima Kelly, John Boyle, Ronan Canavan, B. Donne, M. Kelly, J. J. Barry, C. Leonard, J. V. McLoughlin, Sarah Tait, Maurice Treacy, Sarah Larkin, William A. Schuster, Finian Martin, Carmel Lynch, P. A. Cahill, E. Redmond, A. K. Keenan, T. Barron, S. McGuiness, I. Pratt, M. P. Ryan, D. J. O’Donovan, Pin Yin Lam, T. Young, P. Benson, G. Fitzpatrick, D. C. Moriarty, R. G. Ghaly, J. W. Dundee, K. T. J. Fitzpatrick, E. Fee, A. C. McKay, R. S. J. Clarke, M. S. McKinney, J. P. H. Fee, R. Dwyer, R. S. J. clarke, H. Frizelle, D. Fitzgibbon, W. Blunnie, C. J. Somers, L. O’Mahony, M. Cregg, N. McGuinness, R. Anwyl, J. J. O’Connor, M. J. Rowan, J. Feely, D. O’Neill, M. Rowan, D. Abraham, D. Coakley, J. B. Walsh, R. K. McKinley, J. P. Jamison, M. C. Grouden, S. T. Stanley, M. Sugrue, D. J. Moore, D. G. Shanik, Eilis Carroll, Bemadette Hennelly, B. L. Sheppard, J. Bonnar, D. Kelly, M. D. O’Donnell, P. Dervan, K. F. McGeeney, J. M. Fitzpatrick, S. M. Ward, N. G. McHale, K. M. Sanders, A. Carl, P. King, A. Dunne, I. Kelly, J. R. McCarthy, D. Moriarty, M. G. Davies, A. R. Tuffery, M. Lloyd, A. M. Hetherton, D. B. Poole, D. K. O’Donovan, T. J. McKenna, T. B. Counihan, and P. P. A. Smyth

Subjects
medicine.medical_specialty, business.industry, Ophthalmology, Section (typography), Library science, Medicine, General Medicine, business, Biological sciences
Published
1989

36. Intrathecal morphine in the management of pain following cardiac surgery. A comparison with morphine i.v

Author

G J, Fitzpatrick and D C, Moriarty

Subjects
Adult, Male, Pain, Postoperative, Morphine, Heart Valve Prosthesis, Respiration, Injections, Intravenous, Myocardial Revascularization, Humans, Cardiac Surgical Procedures, Middle Aged, Injections, Spinal, Aged
Abstract

Forty-four patients undergoing coronary revascularization received either intrathecal morphine 1 mg (n = 15), intrathecal morphine 2 mg (n = 15), or i.v. morphine 30 mg (n = 14) after the induction of anaesthesia. Morphine 2.5 mg i.v. was given, as required, in the postoperative period and pain score, respiratory rate and PaCO2 measured every 2 h. FVC, FEV1 and PEFR were measured before, and 24 h after, the induction of anaesthesia. Mean overall pain scores in both intrathecal groups were significantly lower than in the i.v. group (P less than 0.01), but did not differ significantly between the intrathecal groups. Consumption of supplementary morphine was significantly lower in both intrathecal groups (P less than 0.01). Mean PaCO2 was significantly higher in patients given intrathecal morphine 2 mg. This was significant at 12, 14 and 16 h after induction of anaesthesia. Respiratory rate did not differ significantly between the groups. Postoperative PEFR was significantly better in patients given intrathecal morphine (P less than 0.01). These results suggest that intrathecal morphine provided better analgesia after cardiac surgery than did a conventional regimen. The lower dose (1 mg) was associated with less respiratory depression as assessed by PaCO2 measurements.

Published
1988

37. Radial artery cannulation--a prospective study

Author

N. J. McDonald, D. C. Moriarty, and G. J. Fitzpatrick

Subjects
Male, medicine.medical_specialty, Percutaneous, Ischemia, Heart Valve Diseases, Catheters, Indwelling, Postoperative Complications, medicine.artery, medicine, Humans, Radial artery, Coronary Artery Bypass, Prospective cohort study, business.industry, Incidence (epidemiology), Female sex, General Medicine, Arteries, Middle Aged, medicine.disease, Surgery, Cardiac surgery, Anesthesia, Arm, Female, business
Abstract

Percutaneous radial artery cannulation was studied prospectively in 200 patients undergoing elective cardiac surgery. There was no case of infected cannulation site. The frequency of absent radial pulsation was 30% twenty four hours after decannulation, decreasing to 15% four days after decannulation. Factors associated with an increased incidence of an impalpable pulse were female sex (p< 0.001) and prolonged cannulation (p< 0.05).

Published
1987

38. Diagnosis and management of alveolar proteinosis: the rôle of electron microscopy

Author

B Corrin, D C Moriarty, M Turner-Warwick, M A Branthwaite, and J F Costello

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, Pathology, medicine.medical_specialty, Alveolar proteinosis, Therapeutic irrigation, Bronchi, Lung biopsy, Pulmonary Alveolar Proteinosis, Sodium Chloride, law.invention, law, medicine, Humans, Therapeutic Irrigation, Lung, business.industry, Sputum, Sputum examination, respiratory system, medicine.disease, respiratory tract diseases, Radiography, medicine.anatomical_structure, Female, medicine.symptom, Electron microscope, Pulmonary alveolar proteinosis, business, Research Article
Abstract

The diagnosis and management of three cases of pulmonary alveolar proteinosis are described. The electron microscopic appearances of lung biopsy material, lung washings, and sputum and the value of this method of sputum examination in extremely ill patients are demonstrated. The practical details of controlled volume bronchial lavage are described and the good clinical and physiological response of patients reported. The findings have been compared with those of experimental pulmonary alveolar proteinosis, and the pathogenesis of the condition is discussed.

Published
1975

39. Autotransfusion--a brief review

Author

B A, Finegan, D A, Calthorpe, and D C, Moriarty

Subjects
Blood Transfusion, Autologous, Evaluation Studies as Topic, Humans
Published
1983

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