26 results on '"D. Bein"'
Search Results
2. Why Is Hard To Patent An Invention?
- Author
-
D. BEIN, Wolfgang BEIN, M.P. BRUT, and M. CAZACU
- Subjects
patents, e-society ,ComputingMilieux_LEGALASPECTSOFCOMPUTING - Abstract
When employed by a company, in almost all the cases a new employee has to sign an agreement giving the company exclusive rights to any intellectual property developed as part of their work assignments. This agreement could extend beyond a change of jobs and cause conflict of interests in new employment situations. A patent is a government-granted monopoly given to an inventor as both a reward for the intellectual and financial investment, and a stimulus to innovate. As a monopoly, the patent has legal power to exclude others from exploiting the invention in any way for a period of 20 years from the time the patent application has been filed. A trademark provides instant recognition of a product or company; a service mark provides instant recognition of a service. They both have unlimited lifetime. But the owner must renew or confirm continuous use at the end of five years, and every 10 years thereafter. A trade secret is information keep secret by the owner to give him advantage over competitors. Since it is secret, a trade secret protection has unlimited lifetime.
- Published
- 2007
3. Evaluation of disease activity and damage in different subtypes of cutaneous lupus erythematosus using the CLASI
- Author
-
D, Bein, E, Kuehn, A M, Meuth, S, Amler, M, Haust, F, Nyberg, C, Sauerland, T A, Luger, G, Bonsmann, and A, Kuhn
- Subjects
Adult ,Male ,Panniculitis ,Alopecia ,Hypertrophy ,Middle Aged ,Severity of Illness Index ,Cicatrix ,Young Adult ,Erythema ,Antibodies, Antinuclear ,Lupus Erythematosus, Cutaneous ,Humans ,Female ,Atrophy ,Pigmentation Disorders ,Aged ,Skin - Abstract
The Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) is a scoring system for patients with cutaneous lupus erythematosus (CLE) to assess disease activity and damage. Objective The aim of this study was to evaluate whether the CLASI is a useful instrument which reflects the different subtypes of CLE comparably well in each parameter.A total of 50 patients (42 female, 8 male) with different subtypes of CLE, including acute CLE (ACLE), subacute CLE (SCLE), chronic CLE (CCLE) and LE tumidus (LET), from the Departments of Dermatology, University of Düsseldorf, Germany, and Danderyd Hospital, Stockholm, Sweden, were evaluated using the CLASI at one time point.The total CLASI activity score was significantly lower in patients with LET compared with ACLE (P0.05) and CCLE (P0.001), and the total CLASI damage score was significantly lower in patients with LET than with ACLE (P0.05), SCLE (P0.001) and CCLE (P0.001). The erythema score and the scale/hypertrophy score were significantly lower in LET than in ACLE (P0.05, both) and CCLE (P0.05 and P 0.001, respectively). The dyspigmentation score was lowest in patients with LET, differing significantly from ACLE (P0.05), SCLE (P0.05) and CCLE (P0.001). The scarring/atrophy/panniculitis score was significantly higher in patients with CCLE in contrast to SCLE and LET (P0.05 and P0.001, respectively).These data characterize the CLASI as an overall useful instrument to analyse disease activity and damage in CLE. However, the CLASI does not give an accurate assessment of all disease subtypes; therefore, a revision of the CLASI with critical analysis of all parameters is recommended.
- Published
- 2010
4. Revised Cutaneous Lupus Erythematosus Disease Area and Severity Index (RCLASI): a modified outcome instrument for cutaneous lupus erythematosus
- Author
-
A, Kuhn, A M, Meuth, D, Bein, S, Amler, S, Beissert, M, Böhm, R, Brehler, J, Ehrchen, S, Grundmann, M, Haust, V, Ruland, M, Schiller, P, Schulz, S, Ständer, C, Sauerland, W, Köpcke, T A, Luger, and G, Bonsmann
- Subjects
Adult ,Male ,Young Adult ,Lupus Erythematosus, Cutaneous ,Humans ,Reproducibility of Results ,Female ,Middle Aged ,Severity of Illness Index ,Aged - Abstract
In 2005, a scoring system (CLASI, Cutaneous Lupus Erythematosus Disease Area and Severity Index) was developed for patients with cutaneous lupus erythematosus (CLE) to assess disease 'activity' and 'damage'. However, the CLASI does not give an accurate assessment of the severity in all disease subtypes.The main objective of this study was to analyse critically the included parameters of the CLASI and to revise the activity and damage score taking into account various clinical features of the different subtypes of CLE. The revised CLASI (RCLASI) was also validated for use in clinical trials. Patients and methods A RCLASI was designed with regard to the anatomical region (i.e. face, chest, arms) and morphological aspects (i.e. erythema, scaling/hyperkeratosis, oedema/infiltration, scarring/atrophy) of skin lesions and evaluated by nine dermatologists who scored 12 patients with different subtypes of CLE to estimate inter- and intrarater reliability.Reliability studies demonstrated an intraclass correlation coefficient (ICC) for an inter-rater reliability of 0.89 for the activity score [95% confidence interval (CI) 0.79-0.96] and of 0.79 for the damage score (95% CI 0.62-0.92). The ICC for intrarater reliability for the activity score was 0.92 (95% CI 0.89-0.95) and the ICC for the damage score was 0.95 (95% CI 0.92-0.98).In the present study, a RCLASI was developed by experts, and reliability studies supported the validity and applicability of the revised scoring instrument for CLE. Thus, the RCLASI is a valuable instrument in multicentre studies and for the clinical evaluation of activity and damage in different disease subtypes.
- Published
- 2010
5. Fault-Tolerant k-Fold Pivot Routing in Wireless Sensor Networks
- Author
-
D. Bein
- Subjects
Computer science ,business.industry ,Distributed computing ,Approximation algorithm ,Graph theory ,Fault tolerance ,Graph ,Dominating set ,Redundancy (engineering) ,business ,Communication complexity ,Greedy algorithm ,Wireless sensor network ,Computer network - Abstract
Selecting a small set of nodes called pivots, from all the nodes in a network and maintaining the routing infrastructure to and among each other can reduce routing overhead and excessive broadcast redundancy. In this paper a new problem, called "k-fold cover t- set" (for short, k-fold cover), is proposed: we select a smaller set of nodes than the k-fold dominating set, to act as alternative routers for messages in the network. An advantage of the k-fold cover is that it can be defined for graphs where the k-fold dominating set cannot be defined. Computing the minimum size k-fold cover for any k ges 1 is NP-complete. Two approximation algorithms for the k-fold cover problem are proposed: one uses a greedy approach to compute the cover and the other uses randomization.
- Published
- 2008
6. A self-stabilizing directed diffusion protocol for sensor networks
- Author
-
D. Bein and A.K. Datta
- Published
- 2005
7. Fabrication and as-Built Design of the 50 mm Aperture SSC Model Quadrupole Magnets
- Author
-
E. Vrsansky, A. Fluhmann, R. Mihelic, R. England, C. Arden, R. Zeigler, K. Couzens, D. Bailey, R. Jayakumar, Sean P. Stromberg, D. Bein, S. Dwyer, N. Hassan, D. Albone, S. Krishnamurthy, F. Nobrega, A. Jaisle, D. Block, G. Snitchler, S. Phillips, R. Wood, E. McGuire, and S. Smith
- Subjects
Engineering ,Electromagnet ,business.industry ,Aperture ,Mechanical engineering ,Superconducting magnet ,law.invention ,Superconducting Super Collider ,law ,Dipole magnet ,Electrical equipment ,Magnet ,business ,Quadrupole magnet - Abstract
Three 50 mm aperture model quadrupole magnets, designated as QSE-101 through 103, have been built at SSC Laboratory, two of which have have been tested at 4.25 K. The original concepts for the magnet and tooling design as well as assembly procedures have been evaluated in this program. Throughout this process, several magnet components were modified to improve the performance, reliability, and manufacturing of the magnet. The original magnet assembly procedures and design specific tooling were also evaluated and modified to accommodate fabrication of the model magnet. Fabrication and redesign of the model quadrupole magnet has resulted in good magnet performance as well as a more reliable, cost effective, and more production oriented magnet and tooling design. The new concepts which have emerged and the lessons learned from this effort are being applied to the design of magnets and tooling for the SSC Interaction Region quadrupoles as well as other SSC magnets which may be fabricated at the SSC. In this paper a discussion of the magnet and tooling design modifications, assembly processes, and the lessons learned during assembly and evaluation of QSE-101 through 103 is presented.
- Published
- 1994
8. Advances in The Use of Tomographic Inspection Techniques for Non-Destructive Analysis of Geometric Conductor Position and Correlation with Magnetic Cross-Section Modeling
- Author
-
D. Bein, G. Snitchler, G. F. Rabaey, J. Bolger, I. L. Morgan, R. Crane, and M. Vinson
- Subjects
Engineering drawing ,Engineering ,Electromagnet ,business.industry ,Acoustics ,Superconducting magnet ,law.invention ,Conductor ,Cross section (physics) ,law ,Nondestructive testing ,Electrical equipment ,Magnet ,Tomography ,business - Abstract
Industrial Computerized Tomography has been applied to magnet components in various stages of the manufacturing process. These Computerized Tomographic images can be analyzed to infer detailed dimensional information about magnet component positions (conductor, wedges, collars, etc.) throughout the magnet manufacturing process (cable winding, collaring, yoked/skinned). An analysis technique will be presented and measurement accuracies will be discussed.
- Published
- 1994
9. Strain Gauge Pack in Process Measurement System for the Collider Quadrupole, Design and Technology Transfer
- Author
-
G. Novak, Richard E. Zeigler, B. Rodgers, M. Garza, L. Brooks, and D. Bein
- Subjects
Engineering ,Software ,business.industry ,Robustness (computer science) ,System of measurement ,Software development ,Mechanical engineering ,Signal integrity ,Work in process ,business ,Quadrupole magnet ,Strain gauge - Abstract
The in process measurement system that is described below was designed to monitor the strain gauge instrumentation collar pack during all phases of quadrupole magnet manufacture. The primary goal was to implement a monitoring system that incorporated standard measurement techniques while maintaining signal integrity. The flexibility and robustness required in a production environment were taken into account throughout the design and implementation. All major components were chosen from commercially available supplies. The driving software was chosen to provide a user friendly interface while keeping software development efforts to a minimum without sacrificing adaptability.
- Published
- 1994
10. Utilization of Gamma Ray Inspection System for Tomographic Imaging and Dimensional Analysis of Complete Model Magnet Cold Masses and Collared Coil Sections
- Author
-
B. Rice, D. Bein, J. Bolger, L. Morgan, B. Crane, B. Firey, J. Wesick, G. F. Rabaey, and J. Zbasnik
- Subjects
Engineering ,Electromagnet ,business.industry ,Ultrasonic testing ,Electrical engineering ,Polishing ,Mechanical engineering ,Superconducting magnet ,law.invention ,law ,Electromagnetic coil ,Nondestructive testing ,Magnet ,Electrical equipment ,business - Abstract
Non-destructive digital photon transmission imaging can be performed with the IRIS™ system to provide internal component dimensions and locations of manufactured superconducting magnets and sub-assemblies. With non-destructive evaluation of the magnet components and sub-assemblies at critical stages of the manufacturing process, it is possible to assess the quality at each stage with the goal of improving manufacturing reproducibility and reliability. Evaluations of the feasibility of the IRIS™ system have been performed on a NbTi billet used for the production of monofilament rods used in the manufacturing of multifilament strand. The system has also been used to perform inspections on 40-mm and 50-mm collared coil sections and on cold masses. The dimensional accuracy for locating the conductor winding positions in a collared coil section has been found to be ±80 μm. Non-destructive analysis using the IRIS™ system offers examination capabilities in process and post-assembly inspection previously unavailable except through destructive physical analysis by sectioning and polishing for optical inspection after vacuum impregnation. This novel inspection tool may give us deep insights into the validity of our mechanical and electromagnetic models currently used to evaluate magnet design and may lead to substantial savings per magnet analysis.
- Published
- 1992
11. Ultrasonic measurements in sinter-forged high T/sub c/ superconductor YBa/sub 2/Cu/sub 3/O/sub 7- delta
- Author
-
K.R. Poeppelmeier, Q. Robinson, A. Schenstrom, D. Bein, Shireen Adenwalla, Y. Hong, André Moreau, M.F. Xu, B.K. Sarma, Z. Zhao, D. L. Johnson, Shiou-Jyh Hwu, John B Ketterson, and M. Levy
- Subjects
Superconductivity ,Materials science ,High-temperature superconductivity ,Condensed matter physics ,Attenuation ,Ultrasonic testing ,Sintering ,Forging ,Electronic, Optical and Magnetic Materials ,law.invention ,Hysteresis ,law ,Condensed Matter::Superconductivity ,Electrical and Electronic Engineering ,Anisotropy - Abstract
Both ultrasonic attenuation and velocity as a function of temperature from 4.2 K to room temperature were measured on sinter-forged samples of YBa/sub 2/Cu/sub 3/O/sub 7- delta /, which have more than 80% alignment of the c-axis of the grains parallel to the forging axis. Strong anisotropy was found both in the attenuation and the velocity when propagating sound waves in different directions relative to the forging axis. Hysteresis was observed in the velocity changes. >
- Published
- 1989
12. Ultrasonic attenuation measurements in sinter-forgedYBa2Cu3O7−δ
- Author
-
Bimal K. Sarma, André Moreau, Q. Robinson, Kenneth R. Poeppelmeier, Shiou-Jyh Hwu, M. F. Xu, D. Bein, D. L. Johnson, Shireen Adenwalla, John B Ketterson, Moises Levy, R. F. Wiegert, and Z. Zhao
- Subjects
Transverse plane ,Materials science ,Condensed matter physics ,Attenuation ,Isotropy ,Relaxation (NMR) ,Perpendicular ,Anisotropy ,Longitudinal wave ,Forging - Abstract
We report ultrasonic attenuation measurements on sinter-forged YBa/sub 2/Cu/sub 2/O/sub 7-//sub delta/ material, which differs from ordinary sintered material in that the crystallites are preferentially oriented to form a uniaxial sample. Three peaks in attenuation, at temperatures of 250, 180, and 70 K, were observed for longitudinal waves propagating perpendicular to the forging axis, which is similar to that reported in ordinary (isotropic) polycrystalline samples. However, for both transverse and longitudinal sound propagated along the forging axis we have a different behavior, with only one peak at 180 K, showing a strong anisotropy. It is suggested that sound waves traveling parallel to and normal to the Cu-O planes may account for the anisotropic effect, and a relaxation mechanism may explain the increase in shear wave attenuation which was seen with decreasing temperature.
- Published
- 1989
13. Anisotropy of the Magnetic-Field—Induced Phase Transition in Superconducting UPt3
- Author
-
Shireen Adenwalla, Bimal K. Sarma, D. Bein, Z. Zhao, Moises Levy, D. W. Hess, James A Sauls, Y. Hong, A. Schenstrom, T. Tokuyasu, John B Ketterson, David G. Hinks, and M. F. Xu
- Subjects
Superconductivity ,Phase transition ,Materials science ,Field (physics) ,Condensed matter physics ,Condensed Matter::Superconductivity ,General Physics and Astronomy ,Anisotropy ,Critical field ,Magnetic flux ,Vortex ,Magnetic field - Abstract
Measurements of the attenuation of longitudinal ultrasound in superconducting UPt3, show a peak,below Hc2, which depends strongly on the orientation of the field relative to the c axis. We propose an explanation of this peak in terms of a vortex phase transition in an unconventional superconducting state, which is consistent with recent neutron-scattering data.
- Published
- 1989
14. The Theft of Use and the Element of 'Intention to Deprive Permanently’ in Larceny
- Author
-
D. Bein
- Subjects
050502 law ,021110 strategic, defence & security studies ,medicine.medical_specialty ,Status quo ,media_common.quotation_subject ,05 social sciences ,0211 other engineering and technologies ,Punitive damages ,02 engineering and technology ,Temptation ,Civil law (common law) ,Criminal law ,medicine ,Business ,Element (criminal law) ,Law ,Legislator ,Conscience ,0505 law ,Law and economics ,media_common - Abstract
The task of the legislator is indeed difficult when he has to consider and decide how far to extend the area to which the criminal law applies. The difficulty is most apparent in those forms of conduct which are seemingly directed towards some individual to whom civil law remedies are available, for then it must be asked whether these remedies are sufficient or if there is good reason for the addition of criminal sanctions.The usual considerations in this respect are many and various—has the normal victim of the harmful conduct the ways and means himself of resisting it without the assistance of the authorities; does the normal perpetrator of certain kinds of harmful conduct possess sufficient means which enable him to restore the status quo if civilly sued; is conduct of this kind highly frequent; does certain behaviour have a special temptation, which can only be fought by the deterrent force of a criminal sanction; and especially, does the public conscience regard this form of behaviour a serious infringement of public values that justifies and demands public punitive reaction, irrespective of the wishes of the injured person.
- Published
- 1968
15. May the Requirement of Full Intention in Criminal Attempts be Dispensed With?
- Author
-
D. Bein
- Subjects
Law - Published
- 1966
16. Knowledge which Reached a High Degree of Probability
- Author
-
D. Bein
- Subjects
050502 law ,021110 strategic, defence & security studies ,Statement (logic) ,media_common.quotation_subject ,05 social sciences ,0211 other engineering and technologies ,Legislature ,Context (language use) ,02 engineering and technology ,Degree (music) ,Constructive ,Object (philosophy) ,Supreme court ,State (polity) ,Political science ,Law ,0505 law ,Law and economics ,media_common - Abstract
In the decisions of the Israel Supreme Court delivered since the establishment of the State, one sometimes comes across the express or implied statement of the rule that: “the knowledge possessed by the accused at the time of the act that his conduct would lead to a consequence which the legislature desired to prevent, is by a construction of the law regarded as intention to bring about this consequence. ‘Knowledge’ in this context does not necessarily mean ‘full and certain’ knowledge that this consequence is inevitable but on the other hand it must be knowledge which reached a high degree of probability.”The object of this article is to clarify a few aspects of this rule (which, for the sake of brevity, will be referred to as the rule of “constructive intention”).
- Published
- 1967
17. Ultrasonic attenuation in sinter-forged high Tc superconductor YBa2Cu3O7 − δ
- Author
-
Bimal K. Sarma, André Moreau, Shireen Adenwalla, Z. Zhao, Q. Robinson, Shiou-Jyh Hwu, D. L. Johnson, M. F. Xu, Y. Hong, D. Bein, John B Ketterson, Moises Levy, and Kenneth R. Poeppelmeier
- Subjects
Superconductivity ,Shear waves ,Materials science ,Condensed matter physics ,business.industry ,General Engineering ,Yba2cu3o7 δ ,Forging ,Computer Science::Robotics ,Optics ,Ultrasonic attenuation ,Condensed Matter::Superconductivity ,Computer Science::Multimedia ,Perpendicular ,Ultrasonic absorption ,Anisotropy ,business ,Computer Science::Cryptography and Security - Abstract
We have measured ultrasonic absorption in sinter-forged high Tc YBa2Cu3O7 − δ. Owing to the anisotropic properties of the sinter-forged samples, longitudinal ultrasonic attenuation measurements showed very strong anisotropy when waves were propagated parallel and perpendicular to the forging axis. Sound absorption was found to increase with decreasing temperature for shear waves travelling parallel to the forging axis.
- Published
- 1989
18. Anisotropy of the Magnetic-Field-Induced Phase Transition in Superconducting UPt3
- Author
-
A. Schenstrom, Shireen Adenwalla, Y. Hong, Bimal K. Sarma, Moises Levy, M. F. Xu, D. Bein, James A Sauls, Z. Zhao, D. W. Hess, T. Tokuyasu, John B Ketterson, and David G. Hinks
- Subjects
Superconductivity ,Phase transition ,Materials science ,Field (physics) ,Condensed matter physics ,Condensed Matter::Superconductivity ,Orientation (geometry) ,Attenuation ,Anisotropy ,Vortex ,Magnetic field - Abstract
Measurements of the attenuation of longitudinal ultrasound in superconducting UPt3, show a peak,below Hc2, which depends strongly on the orientation of the field relative to the c axis. We propose an explanation of this peak in terms of a vortex phase transition in an unconventional superconducting state, which is consistent with recent neutron-scattering data.
- Published
- 1989
19. The General Part of the Criminal Law of Norway. By Johannes Andenaes. Translated by Thomas P. Ogle [Sweet and Maxwell Ltd.London, 346 pp., £4–4–0.]
- Author
-
D. Bein
- Subjects
Philosophy ,Criminal law ,Theology ,Law - Published
- 1967
20. Evaluation of disease activity and damage in different subtypes of cutaneous lupus erythematosus using the CLASI.
- Author
-
Bein D, Kuehn E, Meuth AM, Amler S, Haust M, Nyberg F, Sauerland C, Luger TA, Bonsmann G, and Kuhn A
- Subjects
- Adult, Aged, Alopecia etiology, Alopecia pathology, Antibodies, Antinuclear blood, Atrophy etiology, Atrophy pathology, Cicatrix etiology, Cicatrix pathology, Erythema etiology, Erythema pathology, Female, Humans, Hypertrophy etiology, Hypertrophy pathology, Lupus Erythematosus, Cutaneous complications, Male, Middle Aged, Panniculitis etiology, Panniculitis pathology, Pigmentation Disorders etiology, Pigmentation Disorders pathology, Young Adult, Lupus Erythematosus, Cutaneous pathology, Severity of Illness Index, Skin pathology
- Abstract
Background: The Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) is a scoring system for patients with cutaneous lupus erythematosus (CLE) to assess disease activity and damage. Objective The aim of this study was to evaluate whether the CLASI is a useful instrument which reflects the different subtypes of CLE comparably well in each parameter., Methods: A total of 50 patients (42 female, 8 male) with different subtypes of CLE, including acute CLE (ACLE), subacute CLE (SCLE), chronic CLE (CCLE) and LE tumidus (LET), from the Departments of Dermatology, University of Düsseldorf, Germany, and Danderyd Hospital, Stockholm, Sweden, were evaluated using the CLASI at one time point., Results: The total CLASI activity score was significantly lower in patients with LET compared with ACLE (P<0.05) and CCLE (P<0.001), and the total CLASI damage score was significantly lower in patients with LET than with ACLE (P<0.05), SCLE (P<0.001) and CCLE (P<0.001). The erythema score and the scale/hypertrophy score were significantly lower in LET than in ACLE (P<0.05, both) and CCLE (P<0.05 and P < 0.001, respectively). The dyspigmentation score was lowest in patients with LET, differing significantly from ACLE (P<0.05), SCLE (P<0.05) and CCLE (P<0.001). The scarring/atrophy/panniculitis score was significantly higher in patients with CCLE in contrast to SCLE and LET (P<0.05 and P<0.001, respectively)., Conclusion: These data characterize the CLASI as an overall useful instrument to analyse disease activity and damage in CLE. However, the CLASI does not give an accurate assessment of all disease subtypes; therefore, a revision of the CLASI with critical analysis of all parameters is recommended., (© 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology.)
- Published
- 2011
- Full Text
- View/download PDF
21. A database analysis of cutaneous lupus erythematosus with the EUSCLE Core Set Questionnaire.
- Author
-
Meuth AM, Amler S, Haust M, Bein D, Sauerland C, Köpcke W, Bonsmann G, Nyberg F, and Kuhn A
- Subjects
- Adolescent, Adult, Aged, Child, Databases as Topic, Feasibility Studies, Female, Germany, Humans, Lupus Erythematosus, Cutaneous classification, Lupus Erythematosus, Cutaneous complications, Lupus Erythematosus, Cutaneous therapy, Male, Middle Aged, Predictive Value of Tests, Reproducibility of Results, Retrospective Studies, Severity of Illness Index, Sweden, Treatment Outcome, Young Adult, Lupus Erythematosus, Cutaneous diagnosis, Surveys and Questionnaires
- Abstract
The aim of this study was to determine whether the Core Set Questionnaire developed recently by the European Society of Cutaneous Lupus Erythematosus (EUSCLE) is a useful tool to evaluate clinical features and therapeutic strategies in cutaneous lupus erythematosus. Disease characteristics were analysed in 50 patients with different subtypes of cutaneous lupus erythematosus from two European centres (Germany and Sweden). Mean age at onset of disease was 42.0 +/- 13.3 years (range: 7-69 years) and this differed significantly between the cutaneous lupus erythematosus subtypes. Moreover, 22 (44.0%) of the patients with cutaneous lupus erythematosus fulfilled four or more of the American College of Rheumatology (ACR) criteria; however, only 7 (14.0%) had severe systemic organ manifestations, such as kidney involvement. The analysis of serological features, such as antinuclear antibodies, revealed further significant differences between the cutaneous lupus erythematosus subtypes. In conclusion, the EUSCLE Core Set Questionnaire provides a useful tool for standardized collection and statistical analysis of data on cutaneous lupus erythematosus in clinical practice.
- Published
- 2010
- Full Text
- View/download PDF
22. Revised Cutaneous Lupus Erythematosus Disease Area and Severity Index (RCLASI): a modified outcome instrument for cutaneous lupus erythematosus.
- Author
-
Kuhn A, Meuth AM, Bein D, Amler S, Beissert S, Böhm M, Brehler R, Ehrchen J, Grundmann S, Haust M, Ruland V, Schiller M, Schulz P, Ständer S, Sauerland C, Köpcke W, Luger TA, and Bonsmann G
- Subjects
- Adult, Aged, Female, Humans, Lupus Erythematosus, Cutaneous pathology, Lupus Erythematosus, Cutaneous physiopathology, Male, Middle Aged, Reproducibility of Results, Young Adult, Lupus Erythematosus, Cutaneous classification, Severity of Illness Index
- Abstract
Background: In 2005, a scoring system (CLASI, Cutaneous Lupus Erythematosus Disease Area and Severity Index) was developed for patients with cutaneous lupus erythematosus (CLE) to assess disease 'activity' and 'damage'. However, the CLASI does not give an accurate assessment of the severity in all disease subtypes., Objectives: The main objective of this study was to analyse critically the included parameters of the CLASI and to revise the activity and damage score taking into account various clinical features of the different subtypes of CLE. The revised CLASI (RCLASI) was also validated for use in clinical trials. Patients and methods A RCLASI was designed with regard to the anatomical region (i.e. face, chest, arms) and morphological aspects (i.e. erythema, scaling/hyperkeratosis, oedema/infiltration, scarring/atrophy) of skin lesions and evaluated by nine dermatologists who scored 12 patients with different subtypes of CLE to estimate inter- and intrarater reliability., Results: Reliability studies demonstrated an intraclass correlation coefficient (ICC) for an inter-rater reliability of 0.89 for the activity score [95% confidence interval (CI) 0.79-0.96] and of 0.79 for the damage score (95% CI 0.62-0.92). The ICC for intrarater reliability for the activity score was 0.92 (95% CI 0.89-0.95) and the ICC for the damage score was 0.95 (95% CI 0.92-0.98)., Conclusions: In the present study, a RCLASI was developed by experts, and reliability studies supported the validity and applicability of the revised scoring instrument for CLE. Thus, the RCLASI is a valuable instrument in multicentre studies and for the clinical evaluation of activity and damage in different disease subtypes.
- Published
- 2010
- Full Text
- View/download PDF
23. The 100th anniversary of lupus erythematosus tumidus.
- Author
-
Kuhn A, Bein D, and Bonsmann G
- Subjects
- Cell Movement, Diagnosis, Differential, History, 20th Century, History, 21st Century, Humans, Lymphocytes immunology, Lymphocytes pathology, Photosensitivity Disorders diagnosis, Photosensitivity Disorders epidemiology, Photosensitivity Disorders pathology, Photosensitivity Disorders physiopathology, Skin immunology, Skin pathology, Lupus Erythematosus, Cutaneous diagnosis, Lupus Erythematosus, Cutaneous epidemiology, Lupus Erythematosus, Cutaneous history, Lupus Erythematosus, Cutaneous pathology, Lupus Erythematosus, Cutaneous physiopathology
- Abstract
In 1909, the term "lupus erythematodes tumidus" was first introduced by the German Dermatologist E. Hoffmann. The next case reports of lupus erythematosus tumidus (LET) were not described until 1930, and in the following years, only a few further cases were reported. This might have been due to the fact that authors have not considered LET as a separate entity different from other variants of cutaneous lupus erythematosus (CLE), and it is likely that skin lesions described under different designations represent the same disease entity. Therefore, LET has been underestimated and neglected in the literature and has been characterized by clinical, histopathological, and immunohistochemical features only in recent years. In particular, phototesting has been crucial in defining LET as a very photosensitive entity of CLE. Up to now, more than 40 reports of LET have been published demonstrating that the course and prognosis of LET are generally more favorable than in other subtypes of CLE. A new classification system, including LET as the intermittent subtype of CLE (ICLE) has been suggested. On the occasion of the 100th anniversary of the first description of LET, we have reviewed the literature and provide here an overview on the different aspects of the disease.
- Published
- 2009
- Full Text
- View/download PDF
24. Membrane environment rather than tissue factor expression determines thrombin formation triggered by monocytic cells undergoing apoptosis.
- Author
-
Stampfuss JJ, Censarek P, Bein D, Schrör K, Grandoch M, Naber C, and Weber AA
- Subjects
- Blood Coagulation Factors physiology, Cell Membrane metabolism, Humans, Staurosporine pharmacology, Thromboplastin genetics, U937 Cells, Apoptosis, Monocytes physiology, Thrombin biosynthesis, Thromboplastin physiology
- Abstract
Monocyte apoptosis is an important determinant of atherothrombosis. Two major mechanisms for apoptosis-associated thrombogenicity have been described: exposure of negatively charged membrane phospholipids and up-regulation of tissue factor (TF). However, the relative importance of these mechanisms is unclear. Thus, procoagulant functions (thrombin generation) of apoptotic (staurosporine, 2 muM, 24 h) U937 cells versus cell-derived microparticles (MPs) were studied. In apoptotic U937 cells, a significant increase in TF mRNA (real-time PCR), surface expression of TF (flow cytometry), and total cellular amount of TF (Western blotting) was observed. Control cells only minimally triggered thrombin generation (endogenous thrombin potential), and apoptotic cells were highly procoagulant. However, addition of negatively charged membranes completely restored the thrombin generation capacity of control U937 cells to the levels of apoptotic cells. MPs (defined as CD45(+) particles of subcellular size), derived from apoptotic U937 cells, were highly procoagulant but did not exhibit an increased TF expression or annexin V binding. Taken together, our data support the concept that the membrane environment, independent of TF expression, determines the extent of thrombin formation triggered by apoptosis of monocytic cells. Externalization of negatively charged phospholipids represents the most important mechanisms for whole cells. Additional yet unknown mechanisms appear to be involved in the procoagulant actions of MPs derived from apoptotic monocytes.
- Published
- 2008
- Full Text
- View/download PDF
25. Ultrasonic attenuation measurements in sinter-forged YBa2Cu3O7- delta.
- Author
-
Xu MF, Bein D, Wiegert RF, Sarma BK, Levy M, Zhao Z, Adenwalla S, Moreau A, Robinson Q, Johnson DL, Hwu SJ, Poeppelmeier KR, and Ketterson JB
- Published
- 1989
- Full Text
- View/download PDF
26. Anisotropy of the magnetic-field-induced phase transition in superconducting UPt3.
- Author
-
Schenstrom A, Xu MF, Hong Y, Bein D, Levy M, Sarma BK, Adenwalla S, Zhao Z, Tokuyasu T, Hess DW, Ketterson JB, Sauls JA, and Hinks DG
- Published
- 1989
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.