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INTRODUCTION: When staying in hyperbaric conditions there is an increase in diuresis, developing a negative water balance, loss of electrolytes and tissue dehydration after diving different in depth, duration, intensity and other parameters, which can be conditionally combined into specific physiological symptom complex – “pressure diuresis” phenomenon (or “diver diuresis”). OBJECTIVE: To investigate the mechanisms of “pressure diuresis” under the action of high gaseous medium pressure and determine the physiological nature of this phenomenon in divers. MATERIALS AND METHODS: 44 men aged 19–23 were examined. In the first study all the subjects had initial sustainability to hyperbaric adverse factors (decompression gas formation – DG, hypoxic hypoxia – HH, nitrogen toxic effect – NTE and oxygen toxic effect – OTE). Hormonal status and body’s osmotic homeostasis rates were defined in all the subjects. The second study evaluated changes of the subjects’ water-electrolyte metabolism, kidney function and osmotic homeostasis during the oral loading renal test with the water load in the baseline and conditions of hyperbaric adverse factor exposure on divers. Statistics: To perform statistical analysis, application packages of Statistica for Windows 10.0 were used. RESULTS: 17 (38,6 %), 29 (65,9 %), 20 (45,5 %) and 35 (79,6 %) subjects had medium and low resistance to DG, HH, OTE and NTE, respectively; 27 (61,4 %), 15 (34,1 %), 24 (54,5 %) and 9 (20,4 %) subjects had high resistance to DG, HH, OTE and NTE. Increase in the concentration of antidiuretic hormone was identified in the diving group with low and medium resistance to NTE, HH, and OTE (by 146,8, 141,1 and 93,2 %, respectively, compared to the results before hyperbaric adverse factor exposure). The highest concentration increase of aldosterone was found among the divers with low and medium resistance to OTE, DG and HH (by 41,5, 39,1 and 36,2 %, respectively). The increase in blood plasma osmolality was observed in the subjects with low and medium resistance to OTE (an increase by 6,6 % compared to the divers with high resistance). A significant reduction in blood plasma osmolality was recorded in the subject group with low and medium resistance to NTE and HH (reduction by 5,2 and 4,2 %, compared to the group with high resistance). The most significant decrease in urine osmolality was identified in the diving group with low and medium resistance to DG and OTE (reduction by 14,5 and 17,7 %, respectively). A significant increase in urine osmolality under the action of hyperbaric factors was defined in the diving group with low and medium resistance to NTE and HH (by 19,8 and 19,3 %). DISCUSSION: The data obtained indicate the emergence of a new body hydration status during person’s staying in hyperbaric conditions. Body hydration status will be connected with its individual resistance to hyperbaric adverse factor effect. Thus, with the development of marked DG iso-osmotic (isotonic) hyperhydration is formed, with OTE hyperosmotic (hypertonic) hyperhydration occurs, with NTE and HH hypo-osmolar (hypotonic) hyperhydration develops. CONCLUSION: The study showed a certain connection (correlation) between types of hyperhydration in the tissues of a diver’s body, mechanisms of occurrence, low and medium initial resistance to a particular hyperbaric factor. “Pressure diuresis” phenomenon (“diver diuresis”), that occurs in divers with high resistance to hyperbaric adverse factors, will be a normal body’s physiological response, aimed at eliminating hypervolemia and reduction in the volume of circulating plasma.

Relevance. Diving equipment and diving launch techniques witness continuous improvements, which allow individuals to more effectively perform various tasks underwater. A controlled electronic closed circuit rebreather has been used in amateur diving in our country for more than 20 years. It is therefore necessary to assess the biochemical effects in deep-sea divers wearing deep sea diving equipment to ensure its safety and functionality in professional diving and the activities of dedicated departmental structures.The objective is to assess the biochemical effects in deep-sea divers in controlled electronic closed circuit rebreather, with a similar level of intravascular decompression gas formation under the influence of aquatic environment factors.Methods. During the study, 9 blood biochemical parameters were evaluated using the Fujifilm DRI-CHEM NX500 apparatus in 6 divers before and after deep-sea descents. In total, 14 diving descents were performed in a controlled electronic closed circuit rebreather to depths from 60 to 100 m. Also, after each diving descent, the level of intravascular decompression gas formation was assessed using ultrasonic location with the constant-wave Doppler effect.Results and Discussion. As a result of these studies, a significant increase in the values of transaminases (ALT, AST) and urea was established, associated with increased partial pressure of oxygen in hyperbaric aquatic environment. The results of the analysis revealed that indicators of the CNS oxygen intoxication correlated with K+ ions concentration and glucose levels; a correlation between Na+ ions and Cl- ions concentration was established, as well as the inverse relationship between the concentration of urea and creatinine and the level of intravascular decompression gas formation. It is noteworthy that a correlation was found between the level of intravascular decompression gas formation and the CNS oxygen intoxication, whereby an increase in the CNS oxygen intoxication leads to increased levels of intravascular decompression gas formation.Conclusion. The studied blood biochemical parameters did not go beyond the reference values and had slight individual variations, which confirms the safety of the technology of descents in diving breathing apparatus with a controlled electronic closed circuit rebreather at depths of more than 60 m. The results of the correlation analysis revealed changes in carbohydrate and water-electrolyte metabolism in the body of divers after a deep-sea descent due to the action of an increased partial pressure of oxygen and intravascular decompression gas formation.

INTRODUCTION: The relevance of this issue is due to the fact that nowadays there is no common understanding of the influence degree of high partial oxygen pressures on a body functions’ state, depending on individual resistance.OBJECTIVE: Research the state of the functions of the central nervous, cardiovascular and respiratory systems among people with different resistance to the toxic oxygen effect in the descending and the nearest post-descending period.MATERIALS AND METHODS: There was an examination of 11 divers aged 23 to 43 (the average age is 35.5±6.5 years) in conditions of a simulated descent in a pressure chamber to the depth of 15 m (0.25 MPa) while breathing oxygen, and also during 3 days after its termination. Statistic: Software SPSS, v. 20.0 (IBM) was applied for statistical processing of the results.RESULTS: Baseline heart rate (HR) in the low toxic oxygen resistant group (group I) is 10% (р< 0.05) higher than the subjects, recognized as resistant (group II). To 60 minutes oxygen breathing (pO2=0.25 MPa) there is a decrease in heart rate (HR) by 12.5% in group I and 11% in group II, comparing the baseline (р< 0.05). An increase of diastolic pressure level in group II is 10.5% to 15 min descent and 18% to 45 min, comparing the baseline (р< 0.05). In group I the pulse pressure level reduced by 18%, comparing the baseline (р< 0.05). Gencha test results after descent rose by 55% in group I and by 62.5% in group II, comparing the baseline (р 0.05), and indicators higher than initial remained for 3 days more. In group I there was reduction of information processing speed by a visual analyzer of 16% (from 0.788 to 0.661 b/sec) and increase in escape latency of a simple visual-motor reaction by 11.7%, comparing the baseline (р< 0.05).DISCUSSION: Divers with different resistance to the toxic oxygen effect experience multidirectional reaction of the central nervous, cardiovascular and respiratory systems. Individuals, resistant to the toxic oxygen effect, are characterized by more active inclusion of counteraction mechanisms to hyperoxia and significant reduction in the level of adaptation reserves and the efficiency of the cardiovascular system. People with low resistance experience a decrease in the functionality level of the central nervous system.CONCLUSION: The results obtained have a basis for admitting the application of the method of determining individual body resistance to the toxic oxygen effect and tests with increasing dosed physical activity in order to estimate adaptation reserves and efficiency.

Introduction. The development of paraprosthetic regurgitation after transcatheter aortic valve implantation (TAVI) in patients with critical aortic stenosis is an actual problem, which predictors are not well understood. One of the main reasons is calcification of the aortic valve, which does not allow the aortic valve prosthesis to fully expand.Objective – to identify a possible relationship between the severity of aortic valve calcification and the degree of paraprosthetic regurgitation after TAVI.Materials and methods. The study included 23 patients with critical symptomatic aortic stenosis and high risk factors for EuroScore II and STS. The single center study is a retrospective analysis of aortic valve calcification measured by preoperative multislice computed tomography. Calcification (calcium index) of the aortic valve was quantified according to the Agatson method. Paraprosthetic regurgitation was evaluated by transthoracic echocardiography according to the ACC/AHA recommendations. The observation period was 12 months. Results. There female patients predominated in the study group (n=15, 65 %). The mean value of the calcium index (CI) of the aortic valve was 5179.7±2334.1 Agatson units. Intraoperatively, half of the patients (n=12, 52 %) after implantation of aortic valve prosthesis had paraprosthetic regurgitation of more than II degree, which required postdilation. The calcium index in this group of patients was significantly higher (6088.3±2274.4, p=0.049). After implantation of an aortal valve prosthesis, paraprosthetic regurgitation of I–II degrees was observed in 16 patients (70 %) with a CI of 5902.1±2191.9, in 7 patients (30 %) with a CI of 3528.7±1537.2 paraprosthetic regurgitation was absent (p=0.021). In the postoperative period (12 months), no lethal outcomes were detected in the study group. Paraprosthetic regurgitation of I–II degrees was detected in 14 patients with a CI of 5676.6±2275, paraprosthetic regurgitation was absent in 9 patients with a CI of 4406.9±2338.3 (p=0.21).Conclusion. Patients with severe calcification of the aortic valve have an increased risk of developing significant paraprosthetic regurgitation and the use of more aggressive intervention techniques.

The purpose of the work: to identify the mechanisms of changes in kidney function and water-electrolyte metabolism in divers with different initial resistance to adverse factors of hyperbaria using oral stress renal tests.Materials and methods. 44 men were examined. Initial resistance to adverse factors of hyperbaria was assessed in all subjects. To determine the state of kidney function, oral stress renal tests were performed under the influence of hypoxia, hyperoxia, toxic nitrogen concentrations and decompression gas formation.Results and their discussion. Changes in kidney function and water-electrolyte metabolism occurring under the action of hyperbaria factors are largely determined by hormonal mechanisms implemented through the renin — angiotensin-aldosterone system (RAAS). Under the action of hypoxia, hyperoxia, toxic nitrogen concentrations and decompression gas formation on unstable subjects, the vector of changes in the activity of RAAS will mainly be directed towards increasing the secretion of antidiuretic hormone and aldosterone.

Historical materials about the life and work of Ivan Akimovich Sapov — major general of the medical service, doctor of medical sciences, professor, chief physiologist of the navy, laureate of the USSR State Prize, honorary member of the I. M. Sechenov physiological society, honorary chairman of the scientific society of barotherapists of St. Petersburg and Leningrad region, honorary doctor of the Military medical academy, honorary academician of the Russian Academy of natural sciences, an outstanding scientist in the field of naval medicine. I. A. Sapov created a scientific school whose main activities were the development of hyperbaric physiology and diving medicine, the physiology of the work of naval specialists and the habitability of navy ships, methods of barotherapy and medical support for rescue operations at sea. The article describes the multifaceted activities of I. A. Sapov as an employee of the research institutes of the navy and as head of the department of physiology of scuba diving and emergency rescue of the Military Medical Academy named after S. M. Kirov, which made it possible to put into practice a set of physiological measures in order to maintain, improve and restore military-professional performance and prevent overwork of military sailors on campaigns.

Aim of the work: to conduct a comparative analysis of methods of ultrasound examination of the right heart with audio and visual indication of intravascular decompression gas formation in divers after diving.Materials and methods. An examination of the right heart in divers after 152 man-descents was carried out. Intravascular decompression gas production was assessed by ultrasound using sound location based on the Doppler effect and transthoracic two-dimensional echocardiography.Results and discussion. Both methods make it possible to determine intravascular decompression gas formation after a diving descent, correlate with the clinical picture of acute decompression sickness and should be used in the medical support of diving descents. At the same time, the method of ultrasound examination based on transthoracic two-dimensional echocardiography turned out to be more sensitive in determining gas bubbles in the right heart as compared to auditory location with the Doppler effect.

Introduction. Treatment of respiratory failure in pneumonia caused by coronavirus infection (COVID-19) is still an unsolved problem that requires a comprehensive approach and the development of new methods that expand the range of possibilities of modern therapy. There is evidence that the heated oxygenhelium mixture has a positive effect on gas exchange in the infiltration zone by improving both ventilation and diffusion.AIM of study. To evaluate the effectiveness of the inclusion of a heated oxygen-helium mixture HELIOX (70% Helium/ 30% Oxygen) in the complex intensive care of respiratory failure of pneumonia caused by SARS-CoV-2 infection.Material and methods. The study included 60 patients with confirmed viral pneumonia caused by COVID-19. The patients were randomized into two groups: group 1 (n=30) — patients who were treated with the standard COVID-19 treatment protocol with the heated oxygen-helium mixture HELIOX, and group 2 (control) (n=30) — patients who received standard therapy. Lethality was studied for 28 days, the time in days until a steady increase in SpO2>96% was achieved when breathing atmospheric air; the time until the patient is transferred from the intensive care unit (ICU) to the general department.Results. Inhalation of the HELIOX mixture (70% Helium / 30% Oxygen) resulted in a faster recovery of the hemoglobin oxygen saturation index (SpO2). Starting from day 3, these differences became statistically significant. The time in days from inclusion in the study to a persistent increase in the degree of oxygen saturation of hemoglobin (SpO2>96%) when breathing atmospheric air in the group with inhalation of the HELIOX mixture was less — 8 (7; 10), compared to 10 (8;13) in the control group (p=0.006). In the group with inhaled HELIOX mixture, the median treatment time in the ICU was 8 (7; 9.5) days vs 13 (8; 17) days (pConclusions. Inhalation of the HELIOX mixture (70% Helium / 30% Oxygen) led to a faster recovery of the hemoglobin oxygen saturation index SpO2, which contributed to reduction in the duration of oxygen therapy and a decrease in mortality.

Aim: using oral stress kidney tests to reveal changes in renal function and water-electrolyte metabolism in divers with different initial resistance to hypoxic hypoxia.Materials and methods. 44 men were studied. All subjects were evaluated for their initial resistance to hypoxic hypoxia. Oral renal stress tests were performed to determine the status of kidney function.Results and their discussion. For the selection of divers, it is necessary to carry out oral stress tests with water, 10% potassium chloride solution and 7.5% calcium lactate solution. In divers with low and medium resistance to hypoxic hypoxia, there is a deterioration in the calcium and potassium uretic function of the kidneys after oral stress renal tests. The method for determining the resistance of divers to hypoxic hypoxia should be supplemented by the regularity developed by us.

2- and 4-(Arylmethylideneamino)phenols react with Reformatsky reagent, obtained from methyl 1-bromocyclohexanecarboxylate and zinc, to form 3-aryl-2-[2-(or 4-)hydroxyphenyl]-2-azaspiro[3.5]nonan-1-ones. The reaction involves the initial addition of the organozinc reagent across the C=N double bond of the Schiff base and the subsequent intramolecular cyclization of the adduct via the nucleophilic attack of the nitrogen atom on the ester carbonyl carbon atom. The structures of the products were confirmed by X-ray diffraction analysis.

Synthetic approaches to previously unknown 4-OR-2-methyltetrahydroquinazoline N-oxides were elaborated. 4-Alkoxy- and 4-aryloxy-2-methyltetrahydroquinazoline N-oxides were investigated in the condensation reactions with aromatic aldehydes to give a series of novel π-conjugated structures with fluorescent properties.

Based on the experience of checking the validity of prices for military products supplied within the frame-work of the state defence order, problematic issues of rationing of labor costs have been identified. The im-perfection of the current regulatory framework in the field of substantiating the labor intensity of work is shown. Proposals for the standardization of labor at various stages of the life cycle of weapons, military and special equipment are reasoned.

Depending on the ring size in the Reformatsky reagent and the nature of substituents in arylmethylidene fragment, the reactions of Reformatsky reagents obtained from methyl esters of 1-bromocycloalkanecarboxylic acids and zinc with N′-(arylmethylidene)-2-oxo-2H-chromene-3-carbohydrazides afforded methyl 1-{3-[2-(arylmethylidene)hydrazinylcarbonyl]-2-oxochroman-4-yl}cycloalkanecarboxylates or methyl 1-{3-[(3-aryl-1-oxo-2-azaspiro[3.5]nonan-2-yl)carbamoyl]-2-oxochroman-4-yl}cyclohexanecarboxylates. The resulting compounds exhibit antinociceptive activity.

The article presents an analysis of publication activity in the field of unmanned aircraft systems based on the Russian Science Citation Index. This area is one of the growth points of FutureSkills competencies, therefore, the study of scientometric parameters is extremely relevant. The main publication centers, universities and institutes and scientific articles that have the highest citations and citations were obtained as the research objectives. The paper presents a retrospective analysis of the intensity of publication and presents the authors and titles of articles with the highest citations. Additionally, the main areas of application of quadcopters are considered. Key words: aeronet, unmanned aerial systems, quadrocopters, analysis of publications, research centers.

Testing and experimental substantiation are a significant and integral part at all phases of the life cycle of reactor equipment. The Research and Testing Complex (RTC) operates at OKBM Afrikantov to ensure that these tasks are successfully fulfilled. The RTC provides the opportunity of performing a wide range of research and testing during the creation of reactor installations as well as the development of the main and auxiliary equipment for the nuclear energy industry. The most significant work performed on the experimental base at OKBM in the last 15–20 years reduces to neutronics and thermotechnical studies of cores and FA, testing equipment for naval and civilian ship reactor installations and NPP, experimental substantiation of systems and study of processes occurring in them and the elements of the equipment in nuclear installations, and the study of the corrosion and strength properties of materials. Work on modernization of currently operating and creation of new test stands is ongoing at the RTC.

OKBM Afrikantov possesses unique experience in developing different types of highly reliable pumping equipment. The pumping equipment developed at the enterprise possesses high safety and reliability metrics at minimum operating cost. OKBM accomplishments in the design and manufacture of pumping equipment over the last 20 years are shown and the basic phases involved in the development of electric pumps for nuclear steam-generating plants, other systems on naval ships and vessels, and pumps for NPP and research and experimental reactor installations as well as electric pumps for the non-nuclear market are described.

1-Aryl-3-(2-hydroxy-5-R-phenyl)prop-2-en-1-ones reacted with the Reformatsky reagent derived from methyl 1-bromocyclohexanecarboxylate to give 4-(2-aryl-2-oxoethyl)-6-R-2H,4H-spiro[[1]benzopyran-3,1′-cyclohexan]-2-ones. The products are formed as a result of intramolecular cyclization of the adduct of the organozinc reagent and substituted chalcone via nucleophilic attack of the phenoxide oxygen atom on the ester carbonyl carbon atom. No cyclization products resulting from attack of the enolate oxygen atom on the ester carbonyl carbon atom were detected.

The use of nuclear energy on submarines has made autonomous and independent navigation possible for long periods of time. OKBM Afrikantov – one of the leading enterprises of the Rosatom State Corporation – has been supplying Russia’s naval ships with nuclear reactor installations for more than 65 years commencing with the development of equipment for the installations on first-generation submarines. Currently, all active ships – second, third, and fourth generation submarines and nuclear surface ships – are powered by reactor installations developed by OKBM. Commencing with the complete nuclear reactor installation set for the Yasen class nuclear submarine, OKBM has functioned as the complete supplier of equipment for all installations developed and being developed for ships and vessels which are under construction or being modernized. Currently, OKBM is designing ship nuclear reactor installations for promising naval ships.

OKBM Afrikantov has been developing power installations for the icebreaker fleet for more than 60 years. The first generation of reactor installations is represented by the OK-150 loop-type installation for the icebreaker Lenin. At the exhaustion of its operating life it was replaced by the second-generation OK-900 installation. The next stage of the origination of reactor installations for civilian ships became the development of KLT-40 and KLT-40M. Currently, owing to the growth of cargo traffic along the Northern Sea Route, the nuclear icebreaker fleet must be enlarged. Both operating and new general-purpose nuclear icebreakers are planned for pilotage of freighters. The new reactor installation RITM-22 with improved metrics was developed for general-purpose icebreakers. The reactor installation RITM-400 was developed for Lidertype icebreakers and can be used in the future in other vessels as well as small nuclear power installations.

Objective. To investigate the dynamics of renal function in patients with resistant arterial hypertension after renal denervation depending on the degree of central and peripheral blood pressure (BP) reduction and the baseline state of the kidneys.Design and methods. A total of 22 patients (mean age 56,1 ± 10,2 years, 9 males) with treated resistant hypertension undergoing bilateral renal denervation (RDN) (Symplicity RDN System, Medtronic, USA) were included. Office BP measuring, 24-hour ambulatory BP monitoring (ABPM) (SpaceLabs 90207, USA), applanation tonometry (SphygmoCor, AtCor Medical, Australia) with the calculation of central aortic blood pressure (CAP), Doppler ultrasonography (Vivid 7 dimension) were obtained at baseline and at 1, 3, 6, 12, 18 and 24 months after RDN. Urine levels of NGAL (neutrophil gelatinase-associated lipocalin), KIM-1 (kidney injury molecule 1), L-FABP (Liver-type fatty acid binding protein), albuminuria and serum levels of сystatin C (sCysC) and creatinine (sCr) were measured by quantitative enzyme immunoassay at baseline and at 1, 3, 6, 12, 18 and 24 months after RDN. Glomerular filtration rate was estimated by the level of sCr and sCysC by CKD-EPI formula.Results. All patients were divided into 3 groups according BP reduction: 1 — BP increase above 0 mm Hg; 2 — BP reduction from 0 to –30 mm Hg; 3 — BP reduction by > 31 mm Hg. An increased sCysС was registered in a group with decreased 24-hour systolic BP (1,06 ± 0,41; 0,93 ± 0,18 and 1,22 ± 0,23 ng/mL; F = 2,882; р = 0,04) and increased urine KIM-1 level — in a group with decreased office diastolic BP (2,18 ± 1,94; 1,53 ± 1,02 and 4,41 ± 0,97 pg/mL; F = 3,663; р = 0,03) at 3-month follow-up. An increased sCr level was registered in a group with decreased 24-hour systolic BP (78,3 ± 3,7; 88,2 ± 6,8 and 142,00 ± 8,8 μmol/L; F = 61,987; p = 0,004) and diastolic CAP (83,4 ± 8,2; 82,0 ± 8,0 and 142,0 ± 9,4 μmol/L; F = 23,476; p = 0,01), also an increased urine L-FABP level — in a group with decreased office diastolic BP (3531,3 ± 1795,0; 997,5 ± 1096,8 and 7351,7 ± 3297,0 pg/mL; F = 12,103; p = 0,002) at 6-month follow up.Conclusions. Renal function worsening in patients during the period of maximum BP lowering may be associated with an excessive BP reduction. Therefore, we can suggest the occurrence of the J-curve phenomenon in relation to the kidneys.

Background Renal sympathetic denervation (RDN) is one of the invasive treatment options for the patients with hypertension (HTN) who are resistant to antihypertensive therapy (AHT). The short-term efficacy of RDN has been proven in a number of randomized clinical trials, but remains controversial, the data on its long-term efficacy are limited. Purpose To evaluate the natural course of HTN, to assess long-term major adverse cardiovascular events (MACEs) and other clinically significant outcomes, as well as AHT efficacy and its features in patients with truly resistant HTN after bilateral RDN during extended prospective follow-up. Methods We included 22 patients with truly resistant HTN (median 57 y.o., 9 males), in whom RDN was performed during 2012–2015 in the clinical center of excellence. We assessed initial and further (after 1 year and after ≥5 years) office and 24-hour BP values, as well as AHT history in detail. Long-term MACEs and other cancer-related outcomes were recorded. The baseline quality of life (QoL) and its dynamics were assessed with the use of EQ-5D-5L questionnaire at all timepoints. Multiple linear regression was used to find possible predictors of the efficacy of RDN. Results The median follow-up after the RDN was 6 (from 5 to 8) years. A significant decrease in office and 24-hour systolic (S) and diastolic BPs was observed at 12 months after RDN compared to initial values (Δ −24 and −12 mm Hg, p Conclusions The RDN shows a pronounced clinical effect in patients with resistant HTN up to 6 years, and is not accompanied by an AHT intensification, and also is not associated with QoL changes. The initial positive trend for QoL completely harked back after 5 years which may be associated with the development of MACEs. The only predictor of RDN positive effect seems to be baseline office SBP levels. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The Russian Science Foundation Study flow-chartChanges in BPs during follow-up

A high-frequency/high-magnetic field (94 GHz/3.3 T) electron paramagnetic resonance (EPR) and electron-nuclear double resonance (ENDOR) study of monocrystalline nanodiamonds (ND) is carried out. Influence of the hydrogen and fluorine modification of the ND surface on EPR and ENDOR signals from the superficial and bulk paramagnetic centers is observed. The effect shows that the ND bulk paramagnetic centers could serve as the intrinsic probe of ND surface modification despite deep localization, shielding from the environment and two-layered surface of the diamond nanoparticle.

The technical characteristics of a power series of reactor installations developed at Afrikantov OKBM are presented. The technical qualities making facilities equipped with modern ship reactor installations commercially attractive are shown to have undergone evolutionary improvement. First and foremost these are facilities for universal nuclear icebreakers under construction and an icebreaker in the design stage. Designs of optimized floating and ground-based power-generating units with improved user qualities are being developed on the basis of the experience gained in the development of a floating nuclear heat-and-power plant based on the Akademik Lomonosov floating power-generating unit. Promising reactors of the type RITM are used in these designs. They differ fundamentally from the block-type units by the integral steam-generating unit, heightened energy resource, and long intervals between refuelings, which are possible owing to the innovative core with metal-ceramic fuel and new structural materials. The possibility of significantly increasing the resource of the new reactor installations is confirmed by its stepped increase on operating nuclear ships and by scientific-technical studies.

In the period 2013—2014, a study was conducted on the market of services for the formation of work groups, taking into account the types of work groups and processes of group dynamics occurring in socio-psychological training. For the basic typology of work groups authors used the Y.M. Zhukov, A.V. Zhuravlev, E.N. Pavlova model. Based on the results of a specially conducted expert survey aimed at identifying the needs of organizations in the formation of work groups, four main types of training for the formation of work groups were identified and characterized, they were named: “Inspiration”, “Challenge”, “Adjusting” and “Joint decision”. As the analysis showed, each type of training is aimed at actualizing certain processes of group dynamics. The survey of the conducted empirical research made it possible to draw a conclusion about the interrelations of the development of the processes of group and socio-psychological management of work groups of various types. The results of this work are unique and can be used for practical purposes to effectively form work groups in organizations. In addition, they represent a methodological value for the training of specialists in the field of management and organizational psychology.

Electron paramagnetic resonance (EPR) study of the impurity Gd3+ ions in the multi-site SrY2O4 crystal isostructural to the magnetically-frustrated SrGd2O4 compound is reported. Analysis of the angular dependences of the EPR spectra at room temperature allowed us to establish the spin-level energy patterns in the ground states of the Gd3+ ions at the Y(1) and Y(2) sites. Parameters of the spin-Hamiltonian in the frames related to the crystal axes and to the principal center axes are determined.

Clinical pattern of the chronic decompression sickness is non-specific and there is objective difficulty to reveal the cause-and-effect relationship between the diver’s health condition and his professional activity in each case. This problem is not only obstructing necessary medical and social aid to the patient but also provides the light-minded relation to the preventive measures organization before diving long-term adverse health effects. A clinical case of professional pathology diagnosed in the diver. The patient served in 1993-2000 in Armed Forces of the Russian Federation as diver-welder, during this period no active complains were demonstrated, as he told, for saving diver’s qualification. In 2000 the patient retired for social and economic reasons and was accepted as a healthy person by a military medical expert commission. Until 2007 he was working by speciality not related to increased pressure terms. In 2007 after medical expert commission examination, the patient continued his work as a civilian personnel diver of the Russian Federation Ministry of Defense, during this time the clear relation between pain syndrome and diving episodes was detected. The patient was self-treated with analgesics and heat physical therapy with unstable effect. In 2014 because of increased lower back pain syndrome, he turned to medical aid. In2015 the diagnosis of chronic decompression sickness was established. Pathogenesis of chronic decompression sickness in not enough investigated, including methodical reasons. Prophylactic measures existing in routine medical diving practice are aimed only for acute non-specific and specific diver’s pathologies and this fact doesn’t favour special attention of the medicals for long-term post-diving effects. It provides to the low efficiency of measures for saving divers, aquanauts and caisson workers professional suitability despite known cases of their health disorders during work experience.

This review focuses on a rare complication of pulmonary arterial hypertension (PAH), extravasation compression of the left coronary artery (LCA) dilated by the pulmonary artery. The review described clinical manifestations and methods for diagnostics of LCA compression, and advantages of the endovascular correction of this complication in patients with pulmonary hypertension. Selection of a device to be implanted during the endovascular intervention in these patients was discussed with due account for concomitant treatment with oral anticoagulants. As an illustration of the issue under discussion, a clinical case of acute coronary syndrome in a female patient from the PAH Registry of the V. A. Almazov National Medical Research Center was provided.

This article discusses the problem of Identity Theft Protection from unauthorized access in computer system. The method of user identification by features of user interacts with computer mouse based on a monitoring of subject activities and using Bayesian networks for identification decision making.

New substituted pyrazolo[3,4-d]pyrimidin-4-ones have been synthesized as a result of a series of transformations including hydrolysis of ethyl 5-amino-1H-pyrazole-4-carboxylates, cyclization of the carboxylic acids thus obtained to pyrazolo[3,4-d][1,3]oxazin-4(1H)-ones, and treatment of the latter with substituted anilines. The final pyrazolo[3,4-d]pyrimidin-4-one derivatives can also be synthesized from 5-(arylamido)-1H-pyrazole-4-carboxylic acids in the presence of a catalytic amount of anhydrous zinc(II) chloride.

Проанализирован опыт медицинского обеспечения глубоководных водолазных спусков в Арктическом регионе в снаряжении с открытой схемой дыхания со сменной подачей искусственных дыхательных газовых смесей. Обследовано 7 водолазов разного возраста и уровня профессиональной подготовки, у которых была проведена проверка устойчивости к факторам повышенного давления и исследовано исходное функциональное состояние организма. По итогам обследования водолазы были разделены на 2 группы: высокоустойчивые к факторам повышенного давления (4 человека) и среднеустойчивые (3 человека). Определена динамика состояния функций сердечно-сосудистой и центральной нервной систем водолазов в процессе погружений. В результате экспедиции группа водолазов, имеющая высокую устойчивость к факторам повышенного давления, совершила рекордное погружение под лед на 102 м.

During the last two decades, endovascular technology has revolutionized the management of patients with abdominal aortic aneurysm (AAA). Today, endovascular aortic repair (EVAR) is the treatment of choice for the majority of patients with an AAA. Randomized controlled trials provide robust evidence for the indication of AAA repair and the rationale for the use of EVAR in selected patients. However, despite that, practice varies and several areas need further elucidation. Important future challenges and areas of research include the role of medical therapy in AAA, whether the indication for repair should be any different in women and in the elderly, and long-term follow-up of patients undergoing complex EVAR with adjuncts, both for elective treatment and for ruptured AAA. Continuous rapid technical and clinical development is to be expected. In this paper, we review the current practice and evidence of stenting in AAA.

Fulminant myocarditis (FM) is a severe form of inflammatory myocardial injury rapidly developing as acute heart failure, cardiogenic shock, or life-threatening disturbances of cardiac rhythm. FM requires intensive treatment including drug therapy, mechanical circulatory support, and in some cases – heart transplantation. Echocardiography can be used as a screening method of diagnostics. Magnetic resonance imaging of the heart often cannot be performed because of hemodynamic instability of a patient, therefore endomyocardial biopsy with histological and immunohistochemical studies as well as molecular-genetic analysis of obtained samples is required for final diagnosis. Prognosis of the disease is determined by histological picture. In most cases, after cessation of acute stage of the inflammatory process, FM has a favorable long-term prognosis. In this article we present a clinical case of FM and review of current literature on diagnosis and treatment of this disease.

Electron paramagnetic resonance studies of the impurity Fe$^{3+}$ and Mn$^{4+}$ centers indicate that the symmetry of the crystal structure of millimeter-scale strontium titanate plates above 105 K lowers in the bulk from cubic to tetragonal, different from that of the conventional low-temperature antiferrodistortive phase. It is shown that the effect does not originate from the residual stress; its magnitude (observed tetragonal distortion) and particular manifestations depend on plate orientation, surface quality and the geometry of a sample. Peculiarities of the observed phenomenon are presented and possible scenario of its realization is discussed., 14 pages, 4 figures

Presented herein is a clinical case report concerning successful simultaneous surgical treatment of a female patient with a complication after transcatheter treatment for chronic dissection of the descending portion of the thoracic aorta. The woman was subjected to elective transcatheter isolation of chronic dissection of the descending thoracic aorta using a stent graft with complete coverage of the zone of the origin of the left subclavian artery. Repeat control imaging studies several months after the intervention revealed residual blood flow through the false channel, directed retrogradely from the distal edge of the stent graft to the left subclavian artery. Besides, the patient was also found to have local dissection of the distal part of the ascending aorta (zone 0). An operative intervention was performed: sternotomy, prosthetic repair of the ascending portion of the aorta and part of the aortic arch, as well as transposition of the left subclavian artery to the left common carotid artery. The control imaging studies confirmed radical removal of the false aneurysm of the ascending aorta and the presence of total thrombosis of the false channel at the level of the stent graft.Представлено клиническое наблюдение успешного одномоментного хирургического лечения больного с осложнением после транскатетерного лечения хронического расслоения нисходящего отдела грудной аорты. Пациентке в плановом порядке выполнена транскатетерная изоляция хронического расслоения нисходящей грудной аорты стент-графтом с полным перекрытием зоны отхождения левой подключичной артерии. При повторных контрольных визуализирующих исследованиях через несколько месяцев после вмешательства выявлен резидуальный кровоток по ложному каналу, направленный ретроградно от дистального края стент-графта в левую подключичную артерию. Кроме того, обнаружено локальное расслоение дистальной части восходящей аорты (зона 0). Выполнено оперативное вмешательство: стернотомия, протезирование восходящего отдела и части дуги аорты, а также транспозиция левой подключичной артерии в левую общую сонную артерию. При контрольных визуализирующих исследованиях подтверждено радикальное устранение ложной аневризмы восходящей аорты и тотальный тромбоз ложного канала на уровне стент-графта.

Aim to assess clinical and prognostic value of circulating cardiospecific autoantibodies (AAB) and CD4+ T-regulatory cells in patients with myocarditis. Material and methods We included into this study 47 patients with lymphocytic myocarditis verified by analysis of histological and immunohistochemical data. Comparison group consisted of 30 practically healthy persons. Content of marker cardiotropic AAT were measured with the help of standardized immune enzyme test-systems. Number of circulating CD4+CD25+ and CD4+CD25+FoxP3+ T-lymphocytes were evaluated by flow cytometry. Results Among factors determining prognosis of patients with lymphocytic myocarditis factors of key significance were the presence of clinically overt heart failure at the disease debut, and degree of reduction of left ventricular ejection fraction. Distinctive feature of active myocarditis was elevation of titer of AABs to sarcomeric, cytoskeleton, and cytoplasmic proteins of cardiomyocytes, as well as elevated level of AABs to various epitopes of adenine nucleotide translocator. Elevated level of AAB to 1-adrenoreceptors was an independent predictor of unfavorable outcome in patients with lymphocytic myocarditis. Increased population of circulating CD4+CD25+ T-regulatory cells was as sociated with elevated concentration of of natriuretic peptide. Conclusion Abnormalities in the system of autoimmunity play key role not only in pathogenesis but also in prognosis of inflammatory myocardial diseases. Changes of profile of circulating cardiospecific AABs and T-regulatory cells can bear a protective function.

Barotherapy in the military medicine. The authors present current data on place and role of hyperbaric oxygenation for military and extreme medicine. Main mechanisms of oxygen saturation and itsdeliveryto cells and tissues of the organisms is described in the given article. The authors proved advantages of the hyperbaric oxygenation over the normobaric and showed its high efficiency for the trauma and suppurative- septic lesion treatment, and for the combat therapeutic pathology. Main clinical and physiological effects of the hyperbaric oxygenation are showed. Modern indications and contra-indications for the use of the hyperbaric oxygenation as a therapeutic mean are proved.

We report a detailed study of electron longitudinal and transverse spin relaxation times for Li donors in monoisotopic 28Si over the temperature range 4–20 K using continuous wave and pulsed electron paramagnetic resonance. Comparison of the obtained spin-lattice relaxation times for the states of the isolated donor center and lithium complex LiO showed that due to the presence of orbital degeneracy, relaxation is faster for single lithium than for the LiO complexes with the nondegenerate ground state. For the isolated lithium center in silicon the relaxation is well described by Blume-Orbach process, with the parameters of the spin-orbit coupling ~ 1·10-6 meV compare to Orbach process for LiO complex with spin-orbit coupling parameter ~ 1.5·10-2 meV.