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Non-organ retroperitoneal tumors are a heterogeneous group of malignant neoplasms that develop from different types of connective tissue, which in turn determines the variety of histological forms. More than 3,000 new cases of soft tissue sarcomas are registered an‑ nually in Russia, which is 1 % of all malignant neoplasms. In 2021, 3150 new cases of malignant neoplasms of connective and other soft tissues were detected for the first time. Retroperitoneal sarcomas account for 10–15 % of all types of soft tissue sarcomas. Diagnosis and treatment of non‑organ retroperitoneal tumors is an extremely difficult task. Non‑organ retroperitoneal tumors of mesenchymal origin are characterized by extremely rapid and aggressive growth. The prognosis of the disease is determined by the variant of the histological structure, the primary localization of the tumor, as well as timely and adequate treatment. Considering that non‑organ retroperitoneal tumors can metastasize to other organs in more than 30 % of cases, they are often detected at an advanced stage. Existing methods of radiation diagnostics and other research methods conducted within the framework of the examination standard, which can generally characterize the primary tumor of the retroperitoneal space, but in more than 60 % of cases give false positive information about the degree of tumor germination into neighboring organs and structures, especially into the main vessels. For this pathology, the main method of treatment is surgical. The long‑term results of surgical treatment and the expediency of palliative removal are currently insufficiently studied. Therefore, it is necessary to improve the methods of diagnosis and surgical treatment of non‑organ malignant tumors of the retroperitoneal space. Correct preoperative assessment of the prevalence and histological structure of the tumor allows you to choose an adequate amount of surgical intervention. This article presents a clinical observation of successful surgical treatment of a patient with solitary fibrous pelvic tumor.

Teratoma is a tumor consisting of several types of tissues derived from one, two or three germ leaves, the presence of which is not peculiar to those organs and anatomical areas of the body in which the tumor develops. According to the WHO classification definition, immature teratomas are those containing embryonic tissues along with definitive, mature tissue structures. In histological WHO classification immature teratomas belong to germ cell ovarian tumors and are in­cluded into the group of teracomas. The prognosis is determined by the variant of the histological structure, the primary localization of the tumor, timely and adequate treatment.This article presents a clinical case of treatment of a young female patient with persistently recurrent pelvic teratoma.The presented observation demonstrates, on the one hand, the unpredictability of the course of the tumor process in embryonic tumors. On the other hand, there were demonstrated the possibilities of surgical treatment of another re­lapse of teratoma in a young patient with a massive tumor of the pelvic cavity in a situation where the hopes for a radical operation according to previous abdominal revisions seemed vague.

Purpose. Study of expression of protein nm23 inprimary and secondary foci of colorectal cancer (CRC) taking in consideration the clinical and morphological features of the disease and the possibility of predicting the risk of distant metastases. Material and methods. The study included postoperative material of 264 CRC patients with I–IV stages of cancer. Immunohistochemical staining performed by biotin-streptavidin immunoperoxidase method on the paraffin tissue sections of primary colon tumors and their metastases in lymph nodes and liver using antibodies against nm23 protein (H‑1 and H‑2) (“Dako”, Denmark). The results were evaluated by semiquantitative method based on the staining intensity and the number of antigen-positive cells and localization of immunoreactivity in cancer cells.Results. During the immunohistochemical study of primary tumors of the colon the increase of the accumulation of nm23 protein was observed in 53.4% (141/264) studied cases. In nmtastasis of CRC the main patterns of expression of a marker characteristic of the corresponding primary tumors was preserved. Survival curves, computed according to the method of Kaplan-Meyer showed that patients with nm23‑positive staining of tumors show a lower 5‑year overall survival than patients with negative immunoreactivity in the tumor. Indicators of disease-free survival in patients with CRC also deteriorated in nm23‑negative status of tumors compared to nm23‑positive status.Conclusion. The overexpression of nm 23 protein were freqently detected in metastasizing primary tumors of colon and their liver metastases and was associated with a high risk of developing distant metastases, and poor outcome of the disease and the deterioration of the postoperative overall and disease-free survival of CRC patients. A high expression level of this marker is a sign of unfavorable prognosis for CRC patients.

AbstractThe liver, lungs, parietal and visceral peritoneum have traditionally been considered to be the main target organs of metastatic colorectal cancer. The isolated adrenal metastasis in colorectal cancer is rare, in the literature there are single observations of clinical cases of successful surgical treatment of such patients. This article presents the clinical observation of successful surgical treatment of patients with colorectal cancer with massive isolated adrenal metastases.

Abstract Immunohistochemical analysis of the expression of E-cadherin, β-catenin, and CD-44v6 proteins was carried out for evaluating the metastatic potential of colorectal cancer cells. Specific features of expression, distribution, and interactions of adhesive molecules in primary tumors of the large intestine and their metastases in the liver and lymph nodes were studied. Reduction and complete absence of E-cadherin expression were much more often observed in patients with colorectal cancer with metastases in the liver than in patients without metastases. Cytoplasmic immunoreactivity and nuclear translocation of β-catenin were increased in more than 80% cases with colorectal adenocarcinoma with metastases. These changes in the expression of E-cadherin and β-catenin in tumor cells can be regarded as factors of unfavorable prognosis of colorectal cancer. No significant relationship between expression of CD-44v6 protein and metastatic potential of cancer cells was detected. [ABSTRACT FROM AUTHOR]