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509 results on '"D Fiore"'

1. The origin of magnetism in a supposedly nonmagnetic osmium oxide

Author

Agrestini, S., Borgatti, F., Florio, P., Frassineti, J., Mosca, D. Fiore, Faure, Q., Detlefs, B., Sahle, C. J., Francoual, S., Choi, J., Garcia-Fernandez, M., Zhou, K. -J., Mitrovic, V. F., Woodward, P. M., Ghiringhelli, G., Franchini, C., Boscherini, F., Sanna, S., and Sala, and M. Moretti

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

A supposedly nonmagnetic 5d$^1$ double perosvkite oxide is investigated by a combination of spectroscopic and theoretical methods, namely resonant inelastic X-ray scattering, X-ray absorption spectroscopy, magnetic circular dichroism, and multiplet ligand field calculations. We found that the large spin-orbit coupling admixes the 5d $t_{2g}$ and $e_g$ orbitals, covalency raises the 5d population well above the nominal value, and the local symmetry is lower than $O_h$. The obtained electronic interactions account for the finite magnetic moment of Os in this compound and, in general, of 5d$^1$ ions. Our results provide direct evidence of elusive Jahn-Teller distortions, hinting at a strong electron-lattice coupling.

Published
2024
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2. Investigation of random telegraph signal in two junction layouts of proton irradiated CMOS SPADs

Author

F. Di Capua, M. Campajola, D. Fiore, L. Gasparini, E. Sarnelli, and A. Aloisio

Subjects
Medicine, Science
Abstract

Abstract This paper focuses on the understanding of the Random Telegraph Signal (RTS) in Single-Photon Avalanche Diodes (SPAD). We studied the RTS of two different SPAD layouts, designed and implemented in a 150-nm CMOS process, after proton irradiation. The two structures are characterized by different junction types: the first structure is constituted by a P+/Nwell junction, while the second is formed by a Pwell/Niso junction. RTS occurrence has been measured in about one thousand SPAD pixels and the differences addressed in two layouts are motivated and discussed. Hypotheses on the RTS origin are drawn by analyzing the RTS time constants and the RTS occurrence evolution as a function of the annealing temperature.

Published
2021
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3. Case Studies for Overcoming Challenges in Using Big Data in Cancer

Author

Shawn M. Sweeney, Hisham K. Hamadeh, Natalie Abrams, Stacey J. Adam, Sara Brenner, Dana E. Connors, Gerard J. Davis, Louis D. Fiore, Susan H. Gawel, Robert L. Grossman, Sean E. Hanlon, Karl Hsu, Gary J. Kelloff, Ilan R. Kirsch, Bill Louv, Deven McGraw, Frank Meng, Daniel Milgram, Robert S. Miller, Emily Morgan, Lata Mukundan, Thomas O'Brien, Paul Robbins, Eric H. Rubin, Wendy S. Rubinstein, Liz Salmi, Teilo H. Schaller, George Shi, Caroline C. Sigman, and Sudhir Srivastava

Subjects
Cancer Research, Oncology
Abstract

The analysis of big healthcare data has enormous potential as a tool for advancing oncology drug development and patient treatment, particularly in the context of precision medicine. However, there are challenges in organizing, sharing, integrating, and making these data readily accessible to the research community. This review presents five case studies illustrating various successful approaches to addressing such challenges. These efforts are CancerLinQ, the American Association for Cancer Research Project GENIE, Project Data Sphere, the National Cancer Institute Genomic Data Commons, and the Veterans Health Administration Clinical Data Initiative. Critical factors in the development of these systems include attention to the use of robust pipelines for data aggregation, common data models, data deidentification to enable multiple uses, integration of data collection into physician workflows, terminology standardization and attention to interoperability, extensive quality assurance and quality control activity, incorporation of multiple data types, and understanding how data resources can be best applied. By describing some of the emerging resources, we hope to inspire consideration of the secondary use of such data at the earliest possible step to ensure the proper sharing of data in order to generate insights that advance the understanding and the treatment of cancer.

Published
2023

9. Chlorthalidone vs. Hydrochlorothiazide for Hypertension-Cardiovascular Events

Author

Areef, Ishani, William C, Cushman, Sarah M, Leatherman, Robert A, Lew, Patricia, Woods, Peter A, Glassman, Addison A, Taylor, Cynthia, Hau, Alison, Klint, Grant D, Huang, Mary T, Brophy, Louis D, Fiore, Ryan E, Ferguson, and Liang, Zhu

Subjects
Adult, Hydrochlorothiazide, Sodium Chloride Symporter Inhibitors, Hypertension, Humans, Chlorthalidone, Blood Pressure, General Medicine, Diuretics, Antihypertensive Agents, Aged
Abstract

Whether chlorthalidone is superior to hydrochlorothiazide for preventing major adverse cardiovascular events in patients with hypertension is unclear.In a pragmatic trial, we randomly assigned adults 65 years of age or older who were patients in the Department of Veterans Affairs health system and had been receiving hydrochlorothiazide at a daily dose of 25 or 50 mg to continue therapy with hydrochlorothiazide or to switch to chlorthalidone at a daily dose of 12.5 or 25 mg. The primary outcome was a composite of nonfatal myocardial infarction, stroke, heart failure resulting in hospitalization, urgent coronary revascularization for unstable angina, and non-cancer-related death. Safety was also assessed.A total of 13,523 patients underwent randomization. The mean age was 72 years. At baseline, hydrochlorothiazide at a dose of 25 mg per day had been prescribed in 12,781 patients (94.5%). The mean baseline systolic blood pressure in each group was 139 mm Hg. At a median follow-up of 2.4 years, there was little difference in the occurrence of primary-outcome events between the chlorthalidone group (702 patients [10.4%]) and the hydrochlorothiazide group (675 patients [10.0%]) (hazard ratio, 1.04; 95% confidence interval, 0.94 to 1.16; P = 0.45). There were no between-group differences in the occurrence of any of the components of the primary outcome. The incidence of hypokalemia was higher in the chlorthalidone group than in the hydrochlorothiazide group (6.0% vs. 4.4%, P0.001).In this large pragmatic trial of thiazide diuretics at doses commonly used in clinical practice, patients who received chlorthalidone did not have a lower occurrence of major cardiovascular outcome events or non-cancer-related deaths than patients who received hydrochlorothiazide. (Funded by the Veterans Affairs Cooperative Studies Program; ClinicalTrials.gov number, NCT02185417.).

Published
2022

13. P443 ACUTE ACALCULOUS CHOLECYSTITIS AND CARDIOVASCULAR DISEASE, WHICH CAME FIRST?

Author

D Fiore and S De Rosa

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background The existence of a close association between disease of the biliary tract and heart‘s disease is known from the mists of time. Acute acalculous cholecystitis (AAC) is a challenging diagnosis. The atypical clinical onset associated to a paucity and similarity of symptoms and to laboratory data mimicking cardiovascular disease (CVD) often results in under and misdiagnosed cases. Moreover, AAC is often associated with gangrene, perforation and empyema as well as considerable morbidity and mortality(up 50%). Early diagnosis is crucial to increase survivability. Even today, there is still a lot of confusion regarding the relationship and consequently the clinical management AAC and CVD. Aim The aim of this review was to provide evidence regarding epidemiology, pathophysiology, clinical presentation and treatment of the complex association between AAC and CVD. Methods we searched for publications addressing Acalculous cholecystitis and cardiovascular disease, consulting Medline and Scopus databases. Any retrospective or prospective study design or systematic review focusing on the aforementioned topic was accepted. This study was conducted in accordance with the PRISMA and AMSTAR Guidelines. Our search rendered 1422 hits (995 from Medline and 427 from Scopus). After progressive screening, 268 full texts were assessed for eligibility and 135 studies were included in qualitative synthesis. Results According to the literature, 11 cases of AAC were reported after cardiopulmonary bypass surgery. Similarly, in 6 of 7 patients following aortic reconstruction. Small vessel occlusion has shown to be the predominant phenomenon in AAC. Histological analysis suggest involvement of ischaemia and reperfusion mediated injury. The most common ECG alterations noted in AAC are changes in T waves in significant leads, slurring and notching of the QRS complex and elevation or depression of the S–T segment, hypothesizing a vagally reflex mechanism, due to the distention of the common bile duct, with a reduced coronary blood flow. Finally it was reported a resolution of ECG changes due to AAC after cholecystectomy or antibiotic treatment within a few days. Conclusion AAC should be suspected after each general disease leading to hypoperfusion such as cardiovascular diseases and major heart or aortic surgery. ECG changes in absence of significant laboratory data for IMA could be related to a misdiagnosed AAC.

Published
2023

14. Sustained Hemostasis With the Padlock™ Over-the-scope Clip for Gastric Fundus Dieulafoy's Lesion in the Setting of Anticoagulation Following Hemorrhagic Shock From Two Dieulafoy's Lesions

Author

Jonathan J Cho, Chelsea M Forbes, Benjamin D Fiore, Joshua D McCarron, and Leybelis Padilla

Subjects
Public Health, Environmental and Occupational Health, General Medicine
Abstract

Dieulafoy’s lesions (DLs) are a rare and difficult-to-identify cause of acute gastrointestinal bleeding that can lead to hemorrhagic shock. We present a case of a 23-year-old previously healthy male presenting with melenic stools and hemorrhagic shock. Computed tomography of abdomen and pelvis with oral and intravenous contrast showed a possible source of hemorrhage as a hyperdense intraluminal material within the stomach. Initial urgent esophagogastroduodenoscopy showed a large, nonbleeding distal esophageal DL, which was treated successfully with 10 mL of 1:10,000 epinephrine and bipolar cauterization with 10 Fr Gold Probe™. Hemorrhage recurred 2 d later, prompting another esophagogastroduodenoscopy, which found another DL within the gastric fundus. Treatment with epinephrine, Gold Probe™, and through-the-scope Hemoclips was unsuccessful because of difficult visualization and positioning. A subsequent attempt was made using the over-the-scope clip (OTSC) Padlock™ Clip Defect Closure System with successful hemostasis and stabilization of the patient. His hospital course was complicated by left lower lobe segmental pulmonary embolism without right heart strain for which he was discharged on 3 months of anticoagulation with apixaban. On follow-up, there was no recurrence of gastrointestinal bleeding (GIB) despite 3 months of anticoagulation. He did not complete the Basic Underwater Demolition/SEAL (BUD/S) Training. This case report demonstrates the evaluation and management of a patient with hemorrhagic shock from two DLs and sustained hemostasis with the Padlock™ OTSC in the setting of apixaban anticoagulation.

Published
2022

15. Investigation of random telegraph signal in two junction layouts of proton irradiated CMOS SPADs

Author

M. Campajola, D. Fiore, Ettore Sarnelli, Leonardo Gasparini, Alberto Aloisio, F. Di Capua, Di Capua, F, Campajola, M, Fiore, D, Gasparini, L, Sarnelli, E, and Aloisio, A

Subjects
010302 applied physics, Physics, Multidisciplinary, Proton, 010308 nuclear & particles physics, business.industry, Science, Time constant, 01 natural sciences, Signal, Article, Optics and photonics, CMOS, 0103 physical sciences, Optoelectronics, Medicine, Irradiation, business, Cmos process, Diode
Abstract

This paper focuses on the understanding of the Random Telegraph Signal (RTS) in Single-Photon Avalanche Diodes (SPAD). We studied the RTS of two different SPAD layouts, designed and implemented in a 150-nm CMOS process, after proton irradiation. The two structures are characterized by different junction types: the first structure is constituted by a P+/Nwell junction, while the second is formed by a Pwell/Niso junction. RTS occurrence has been measured in about one thousand SPAD pixels and the differences addressed in two layouts are motivated and discussed. Hypotheses on the RTS origin are drawn by analyzing the RTS time constants and the RTS occurrence evolution as a function of the annealing temperature.

Published
2021

36. Design of a pragmatic clinical trial embedded in the Electronic Health Record: The VA's Diuretic Comparison Project

Author

Areef, Ishani, Sarah M, Leatherman, Patricia, Woods, Cynthia, Hau, Alison, Klint, Robert A, Lew, Addison A, Taylor, Peter A, Glassman, Mary T, Brophy, Louis D, Fiore, Ryan E, Ferguson, and William C, Cushman

Subjects
Hydrochlorothiazide, Hypertension, Chlorthalidone, Electronic Health Records, Humans, Blood Pressure, Pharmacology (medical), Prospective Studies, General Medicine, Diuretics, Antihypertensive Agents
Abstract

Recent US guidelines recommend chlorthalidone over other thiazide-type diuretics for the treatment of hypertension based on its long half-life and proven ability to reduce CVD events. Despite recommendations most clinicians prescribe hydrochlorothiazide (HCTZ) over chlorthalidone (CTD). No randomized controlled data exist comparing these two diuretics on cardiovascular outcomes.The Diuretic Comparison Project (DCP) is a multicenter, two-arm, parallel, Prospective Randomized Open, Blinded End-point (PROBE) trial testing the primary hypothesis that CTD is superior to HCTZ in the prevention of non-fatal CVD events and non-cancer death. Patients with hypertension taking HCTZ 25 or 50 mg were randomly assigned to either continue their current HCTZ or switch to an equipotent dose of CTD. The primary outcome is time to the first occurrence of a composite outcome consisting of a non-fatal CVD event (stroke, myocardial infarction, urgent coronary revascularization because of unstable angina, or hospitalization for acute heart failure) or non-cancer death. The trial randomized 13,523 patients at 72 VA medical centers. The study is conducted by a centralized research team with site procedures embedded in the electronic health record and all data collected through administrative claims data, with no study related visits for participants. The trial will have 90% power to detect an absolute reduction in the composite event rate of 2.4%.Enrollment ended in November 2021. There are 4128 participting primary care providers and 16,595 patients individually consented to participate, 13,523 of whom were randomized.DCP should provide much needed evidence as to whether CTD is superior to HCTZ in preventing cardiovascular events in hypertensive patients.NCT02185417 [https://clinicaltrials.gov/ct2/show/NCT02185417].

Published
2022

37. The novel use of EUS-guided fine-needle biopsy for the diagnosis of eosinophilic gastroenteritis

Author

Angela M. Bachmann, Chelsea M. Forbes, Benjamin D. Fiore, Derek W. Grady, and R. Daniel Lawson

Subjects
medicine.medical_specialty, business.industry, Gastroenterology, medicine.disease, Enteritis, Fine needle biopsy, Gastritis, Eosinophilia, Eosinophilic gastroenteritis, medicine, Humans, Radiology, Nuclear Medicine and imaging, Radiology, business, Endoscopic Ultrasound-Guided Fine Needle Aspiration
Published
2021

40. Clarification of Eosinophilic Esophagitis Treatment in the DoD Retention Standards

Author

Joseph Cheatham, Benjamin D. Fiore, and Austin D. Gable

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Public Health, Environmental and Occupational Health, Proton Pump Inhibitors, Immunosuppression, Medical evaluation, Eosinophilic Esophagitis, General Medicine, Disease, medicine.disease, Chronic inflammatory disease, Dysphagia, medicine.anatomical_structure, medicine, Humans, Oral steroid therapy, Steroids, Esophagus, medicine.symptom, Deglutition Disorders, Eosinophilic esophagitis, Intensive care medicine, business
Abstract

The DoD Instruction 6130.03, Volume 2, outlines the retention standards for the U.S. Military, providing guidance on medical conditions and treatments that are disqualifying for all branches of the military. This document states that patients with conditions requiring immunomodulating or immunosuppressant medications do not meet retention standards. Eosinophilic esophagitis is a common, chronic inflammatory disease of the esophagus that typically presents with dysphagia. Although proton pump inhibitors are effective at treating this disease in some cases, swallowed topical steroids are the most frequently used therapy within the DoD. These medications act locally in the esophagus and do not cause systemic side effects typical of oral steroid therapy, including immunosuppression. They are effective at inducing and maintaining disease remission and are generally well tolerated, with minimal side effects. We propose a brief amendment to this document to clarify the language used and avoid inappropriate Medical Evaluation Board referrals.

Published
2021

41. Discrete-time closed-loop inverse kinematics: A comparison between Euler and RK4 methods

Author

Ciro Natale, Mario D. Fiore, Mariagrazia Dotoli, Laura Giarré, Fiore, M. D., and Natale, C.

Subjects
Inverse kinematics, Differential equation, Numerical analysis, Kinematics, law.invention, symbols.namesake, Singularity, Discrete time and continuous time, law, Euler's formula, symbols, Applied mathematics, Cartesian coordinate system, Mathematics
Abstract

This paper investigates the effects of the numerical method employed to solve the system of differential equations that characterise a closed-loop inverse kinematics (CLIK) algorithm in the discrete-time domain. The paper presents a detailed comparison between a 4th order method, namely the Runge-Kutta 4 (RK4) and the explicit Euler 1-st order method, that is the one most often used in applications. In spite of a lower complexity of the mathematical model, simulations on a 7-Degree-Of-Freedom (DOF) show that using explicit Euler produces better performance in some conditions, such as when considering a constant Cartesian reference. On the other hand, significantly lower tracking error is observed for time-varying Cartesian reference when using RK4. This method also generates smoother joint trajectories when moving through a kinematic singularity. Finally, the results suggest that the stability of the closed-loop algorithm is retained for larger gain values when using RK4.

Published
2021

44. Redundancy resolution under hard joint constraints: a generalized approach to rank updates

Author

Jan Peters, Anton Ziese, Mario D. Fiore, Uwe Zimmermann, and Jürgen Adamy

Subjects
0209 industrial biotechnology, Mathematical optimization, business.industry, Generalization, Computer science, Rank (computer programming), Robotics, 02 engineering and technology, Kinematics, Degrees of freedom (mechanics), Computer Science::Robotics, 020901 industrial engineering & automation, Joint constraints, 0202 electrical engineering, electronic engineering, information engineering, Redundancy (engineering), Torque, Robot, 020201 artificial intelligence & image processing, Artificial intelligence, business
Abstract

The increasing interest in autonomous robots with a high number of degrees of freedom for industrial applications and service robotics have also increased the demand for efficient control algorithms. The unstructured environment these robots operate in often impose constraints on the joint motion, an important type being the joint limits of the robot itself. These circumstances demand control algorithms to handle multiple tasks as well as constraints efficiently. This paper shows that both kinematic and torque control of redundant robots under hard joint constraints can be formulated in a single framework as a constrained optimization problem. To solve said problem, a generalization of the Fast-SNS algorithm to weighted pseudoinverses is proposed, which fulfills our demand of efficiently and reliably handling joint constraints.

Published
2020

45. Geometrical Interpretation and Detection of Multiple Task Conflicts using a Coordinate Invariant Index

Author

Mario D. Fiore, Vincenzo Schettino, Fanny Ficuciello, Felix Allmendinger, Johannes Lachner, Claudia Pecorella, Stefano Stramigioli, Bruno Siciliano, Digital Society Institute, Robotics and Mechatronics, Schettino, V., Fiore, M. D., Pecorella, C., Ficuciello, F., Allmendinger, F., Lachner, J., Stramigioli, S., and Siciliano, B.

Subjects
0209 industrial biotechnology, Robot kinematics, Computer science, 02 engineering and technology, Task (project management), 020901 industrial engineering & automation, Control theory, Path (graph theory), 0202 electrical engineering, electronic engineering, information engineering, Trajectory, Task analysis, Robot, 020201 artificial intelligence & image processing, Invariant (computer science)
Abstract

Modern robots act in dynamic and partially unknown environments where path replanning can be mandatory if changes in the environment are observed. Task-prioritized control strategies are well known and effective solutions to ensure local adaptation of robot behaviour. The highest priority in a stack of tasks is typically given to the management of correct robot operation or safe interaction with the environment such as obstacles or joint limits avoidance, that we can consider as constraints. If a constraint makes impossible achieving a certain task, such as tracking a Cartesian trajectory, a local control algorithm partially sacrifices the latter which is only accomplished to the best of the robot's ability to generate internal motions. In this control framework, problems may occur in some applications, like in the surgical domain, where it is not safe that some tasks are simply sacrificed without prior notice. The contribution of this work is to introduce a coordinate invariant index, that is used to provide a geometrical interpretation of task conflicts in a task-priority control framework and to develop a method for on-line detection of algorithmic singularities, with the goal of increasing safety and performances during robot operations.

Published
2020

46. Tattoo Trouble: A Case of Drug-induced Thrombocytopenic Purpura

Author

Alexander Jahncke, Victoria Kay, and Benjamin D. Fiore

Subjects
Adult, Male, medicine.medical_specialty, 0211 other engineering and technologies, Physical examination, 02 engineering and technology, 03 medical and health sciences, 0302 clinical medicine, Trimethoprim, Sulfamethoxazole Drug Combination, medicine, Humans, 030212 general & internal medicine, 021110 strategic, defence & security studies, Past medical history, Purpura, Thrombocytopenic, Idiopathic, medicine.diagnostic_test, Drug-induced thrombocytopenic purpura, Tattooing, business.industry, Public Health, Environmental and Occupational Health, General Medicine, Petechial rash, Exanthema, medicine.disease, Rash, Pancytopenia, Thrombocytopenic purpura, Dermatology, Thrombocytopenia, Anti-Bacterial Agents, Cellulitis, medicine.symptom, business
Abstract

Trimethoprim–sulfamethoxazole, otherwise known as Bactrim or Septra, is a commonly prescribed antibiotic for soft tissue infections. Drug-induced thrombocytopenia is a rare but serious adverse reaction to sulfonamide antibiotics like Bactrim/Septra. A 34-year-old active duty marine male with no significant past medical history presented with a chief complaint of a rash on his lower extremities. The patient stated that 2 weeks earlier, he was prescribed Bactrim for cellulitis at the site of a new tattoo. The intern noted a petechial rash that was pathognomonic for thrombocytopenia. Laboratory testing confirmed the patient’s thrombocytopenia with platelets of 2,000/μL on initial complete blood count, without pancytopenia or other coagulopathies. The blood smear indicated a profound lack of platelets but otherwise normal cell counts and morphology. In the emergency department, the patient was typed and crossed, platelets were ordered, and hematology–oncology was consulted. Once admitted to the internal medicine ward, he was administered glucocorticoids as well as platelet transfusions. He was monitored for 3 days and discharged with a diagnosis of resolved drug-induced thrombocytopenia. This case illustrates the importance of conducting a thorough review of systems and physical examination in stable and otherwise healthy patients. In this case, the seemingly benign rash was one of the only clinical signs of severe thrombocytopenia, with a high risk of spontaneous bleeding in clinically significant organ systems. It is important to recognize immune thrombocytopenic purpura as a potential complication of Bactrim/Septra, as this antibiotic is widely used by military providers in operational settings.

Published
2020

47. Bose-Einstein correlations of charged hadrons in proton-proton collisions at s=13 TeV

Author

Sirunyan, A. M. Tumasyan, A. Adam, W. Ambrogi, F. and Asilar, E. Bergauer, T. Brandstetter, J. Dragicevic, M. and Eroe, J. Del Valle, A. Escalante Flechl, M. Fruehwirth, R. and Ghete, V. M. Hrubec, J. Jeitler, M. Krammer, N. and Kraetschmer, I Liko, D. Madlener, T. Mikulec, I Rad, N. and Rohringer, H. Schieck, J. Schoefbeck, R. Spanring, M. and Spitzbart, D. Taurok, A. Waltenberger, W. Wittmann, J. and Wulz, C-E Zarucki, M. Chekhovsky, V Mossolov, V and Gonzalez, J. Suarez De Wolf, E. A. Di Croce, D. Janssen, X. and Lauwers, J. Pieters, M. Van Haevermaet, H. Van Mechelen, P. Van Remortel, N. Abu Zeid, S. Blekman, F. D'Hondt, J. and De Bruyn, I De Clercq, J. Deroover, K. Flouris, G. and Lontkovskyi, D. Lowette, S. Marchesini, I Moortgat, S. and Moreels, L. Python, Q. Skovpen, K. Tavernier, S. Van Doninck, W. Van Mulders, P. Van Parijs, I Beghin, D. and Bilin, B. Brun, H. Clerbaux, B. De Lentdecker, G. and Delannoy, H. Dorney, B. Fasanella, G. Favart, L. and Goldouzian, R. Grebenyuk, A. Kalsi, A. K. Lenzi, T. and Luetic, J. Postiau, N. Starling, E. Thomas, L. Vander Velde, C. Vanlaer, P. Vannerom, D. Wang, Q. Fang, W. and Gao, X. Cornelis, T. Dobur, D. Fagot, A. Gul, M. and Khvastunov, I Poyraz, D. Roskas, C. Trocino, D. Tytgat, M. Verbeke, W. Vermassen, B. Vit, M. Zaganidis, N. and Bakhshiansohi, H. Bondu, O. Brochet, S. Bruno, G. and Caputo, C. David, P. Delaere, C. Delcourt, M. Francois, B. Giammanco, A. Krintiras, G. Lemaitre, V Magitteri, A. and Mertens, A. Musich, M. Piotrzkowski, K. Saggio, A. and Marono, M. Vidal Wertz, S. Zobec, J. Alves, F. L. Alves, G. A. Correa Martins Junior, M. Correia Silva, G. Hensel, C. and Moraes, A. Pol, M. E. Rebello Teles, P. Belchior Batista Das Chagas, E. Carvalho, W. Chinellato, J. Coelho, E. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. De Oliveira Martins, C. Fonseca De Souza, S. Malbouisson, H. and Matos Figueiredo, D. Melo De Almeida, M. Mora Herrera, C. and Mundim, L. Nogima, H. Prado Silva, W. L. Sanchez Rosas, L. J. Santoro, A. Sznajder, A. Thiel, M. Tonelli Manganote, E. J. Torres Da Silva De Araujo, F. Vilela Pereira, A. and Ahuja, S. Bernardes, C. A. Calligaris, L. Fernandez Perez Tomei, T. R. Novaes, S. F. Padula, SandraS Gregores, E. M. and Mercadante, P. G. Aleksandrov, A. Hadjiiska, R. and Iaydjiev, P. Marinov, A. Misheva, M. Rodozov, M. and Shopova, M. Sultanov, G. Dimitrov, A. Litov, L. Pavlov, B. Petkov, P. Yuan, L. Ahmad, M. Bian, J. G. Chen, G. M. Chen, H. S. Chen, M. Chen, Y. Jiang, C. H. and Leggat, D. Liao, H. Liu, Z. Romeo, F. Shaheen, S. M. and Spiezia, A. Tao, J. Wang, Z. Yazgan, E. Zhang, H. and Zhang, S. Zhao, J. Ban, Y. Chen, G. Levin, A. Li, J. and Li, L. Li, Q. Mao, Y. Qian, S. J. Wang, D. Xu, Z. Wang, Y. Avila, C. Cabrera, A. Carrillo Montoya, C. A. Chaparro Sierra, L. F. Florez, C. Gonzalez Hernandez, C. F. Segura Delgado, M. A. Courbon, B. Godinovic, N. and Lelas, D. Bee, C. P. Puljak, I Sculac, T. Antunovic, Z. and Kovac, M. Brigljevic, V Ferencek, D. Kadija, K. and Mesic, B. Starodumov, A. Susa, T. Ather, M. W. Attikis, A. Kolosova, M. Mavromanolakis, G. Mousa, J. Nicolaou, C. Ptochos, F. Razis, P. A. Rykaczewski, H. Finger, M. and Fingera, Jr., M. Ayala, E. Carrera Jarrin, E. Abdalla, H. Mahrous, A. Mohamed, A. Bhowmik, S. De Oliveira, A. Carvalho Antunes Dewanjee, R. K. Ehataht, K. Kadastik, M. and Raidal, M. Veelken, C. Eerola, P. Kirschenmann, H. and Pekkanen, J. Voutilainen, M. Havukainen, J. Heikkila, J. K. and Jarvinen, T. Karimaki, V Kinnunen, R. Lampen, T. and Lassila-Perini, K. Laurila, S. Lehti, S. Linden, T. and Luukka, P. Maenpaa, T. Siikonen, H. Tuominen, E. and Tuominiemi, J. Tuuva, T. Besancon, M. Couderc, F. and Dejardin, M. Denegri, D. Faure, J. L. Ferri, F. Ganjour, S. Givernaud, A. Gras, P. de Monchenault, G. Hamel and Jarry, P. Leloup, C. Locci, E. Malcles, J. Negro, G. and Rander, J. Rosowsky, A. Sahin, M. O. Titov, M. and Abdulsalam, A. Amendola, C. Antropov, I Beaudette, F. and Busson, P. Charlot, C. de Cassagnac, R. Granier Kucher, I and Lobanov, A. Blanco, J. Martin Perez, C. Martin Nguyen, M. Ochando, C. Ortona, G. Paganini, P. Pigard, P. and Rembser, J. Salerno, R. Sauvan, J. B. Sirois, Y. Leiton, A. G. Stahl Zabi, A. Zghiche, A. Agram, J-L Andrea, J. and Bloch, D. Brom, J-M Chabert, E. C. Cherepanov, V and Collard, C. Conte, E. Fontaine, J-C Gele, D. Goerlach, U. Jansova, M. Le Bihan, A-C Tonon, N. Van Hove, P. and Gadrat, S. Beauceron, S. Bernet, C. Boudoul, G. Chanon, N. Chierici, R. Contardo, D. Depasse, P. El Mamouni, H. and Fay, J. Finco, L. Gascon, S. Gouzevitch, M. Grenier, G. Ille, B. Lagarde, F. Laktineh, I. B. Lattaud, H. and Lethuillier, M. Mirabito, L. Perries, S. Popov, A. and Sordini, V Touquet, G. Vander Donckt, M. Viret, S. and Toriashvili, T. Bagaturia, I Autermann, C. Feld, L. and Kiesel, M. K. Klein, K. Lipinski, M. Preuten, M. Rauch, M. P. Schomakers, C. Schulz, J. Teroerde, M. 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Wolfe, E. Xia, F. Harr, R. Karchin, P. E. Poudyal, N. Sturdy, J. Thapa, P. and Zaleski, S. Brodski, M. Buchanan, J. Caillol, C. and Carlsmith, D. Dasu, S. Dodd, L. Gomber, B. Grothe, M. and Herndon, M. Herve, A. Hussain, U. Klabbers, P. and Lanaro, A. Long, K. Loveless, R. Ruggles, T. Savin, A. and Smith, N. Smith, W. H. Woods, N. CMS Collaboration

Abstract

Bose-Einstein correlations of charged hadrons are measured over a broad multiplicity range, from a few particles up to about 250 reconstructed charged hadrons in proton-proton collisions at s = 13 TeV. The results are based on data collected using the CMS detector at the LHC during runs with a special low-pileup configuration. Three analysis techniques with different degrees of dependence on simulations are used to remove the non-Bose-Einstein background from the correlation functions. All three methods give consistent results. The measured lengths of homogeneity are studied as functions of particle multiplicity as well as average pair transverse momentum and mass. The results are compared with data from both CMS and ATLAS at s = 7 TeV, as well as with theoretical predictions.

Published
2020

48. Characteristics and management of pancreatic lesions in Von Hippel-Lindau disease: a systematic literature review

Author

Giuseppe Lombardi, F. Zustovich, S. Zovato, D. Fiore, A. Cappetta, and D. Pastorelli

Subjects
VHL - NET - Pancreas - Tumors, Other systems of medicine, RZ201-999, Internal medicine, RC31-1245
Abstract

Von Hippel-Lindau disease is a rare autosomal dominant inherited disorder that predisposes the occurrence of cysts and various types of cancers such as hemangioblastoma, pheochromocytoma, renal cell carcinoma and more rarely pancreatic tumors. In this review, we analyze the characteristics and management of pancreatic lesions, in particular cysts and neuroendocrine tumors, in Von Hippel-Lindau disease.

Published
2011
Full Text
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