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3,852 results on '"D Ding"'

1. Microphysical view of the development and ice production of mid-latitude stratiform clouds with embedded convection during an extratropical cyclone

Author: Y. Du, D. Liu, D. Zhao, M. Huang, P. Tian, D. Wen, W. Xiao, W. Zhou, H. He, B. Pan, D. Zuo, X. Liu, Y. Jing, R. Zhang, J. Sheng, F. Wang, Y. Huang, Y. Chen, and D. Ding
Subjects: Physics, QC1-999, Chemistry, QD1-999
Abstract: The microphysical properties associated with ice production importantly determine precipitation rates. In this study, the microphysical properties of stratiform clouds with embedded convection during an extratropical cyclone over northern China were characterized in situ. Stages of clouds, including young cells rich in liquid water and developing and mature stages with high number concentrations of ice particles (NIce), were investigated. NIce could reach 300 L−1 in the mature stage, approximately 2 orders of magnitude higher than the primary NIce. The secondary ice production (SIP) rate was 0.005–1.8 L−1 s−1, which was derived from the measured NIce. The SIP rate could be produced using a simplified collision–coalescence model by considering the collection of large droplets by graupel. The collection efficiency between the graupel and the droplet was found to increase when the size of the droplet approached that of the graupel, which may improve the agreement between the measurements and the model. Importantly, the overall NIce was found to be highly related to the distance to the cloud top (DCT). The level with a larger DCT had more rimed graupel falling from the upper levels, which promoted coalescence processes between the graupel and the droplets, producing a greater fraction of smaller ice. This seeder–feeder process extended the avalanche SIP process at lower temperatures to −14 °C, beyond the temperature region of the Hallett–Mossop process. The results illustrate the microphysical properties of clouds with convective cells at different stages, which will improve the understanding of the key processes in controlling the cloud glaciation and precipitation processes.
Published: 2024
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2. Mid-21st century ozone air quality and health burden in China under emissions scenarios and climate change

Author: D M Westervelt, C T Ma, M Z He, A M Fiore, P L Kinney, M-A Kioumourtzoglou, S Wang, J Xing, D Ding, and G Correa
Subjects: ozone, climate change, China, health, model, Environmental technology. Sanitary engineering, TD1-1066, Environmental sciences, GE1-350, Science, Physics, QC1-999
Abstract: Despite modest emissions reductions of air pollutants in recent years, China still suffers from poor air quality, and the outlook for future air quality in China is uncertain. We explore the impact of two disparate 2050 emissions scenarios relative to 2015 in the context of a changing climate with the Geophysical Fluid Dynamics Laboratory Atmospheric Model version 3 (GFDL-AM3) chemistry-climate model. We impose the same near-term climate change for both emission scenarios by setting global sea surface temperature (SST) and sea ice cover (SIC) to the average over 2010–2019 and 2046–2055, respectively, from a three-member ensemble of GFDL coupled climate model simulations under the RCP8.5 (Representative Concentration Pathway) scenario. By the 2050s, annual mean surface ozone increases throughout China by up to 8 ppbv from climate change alone (estimated by holding air pollutants at 2015 levels while setting SIC and SST to 2050 conditions in the model) and by 8–12 ppbv in a scenario in which emissions of ozone precursors nitrogen oxides (NO _x ) and anthropogenic volatile organic compounds (VOCs) increase by ∼10%. In a scenario in which NO _x and anthropogenic VOC emissions decline by 60%, annual mean surface ozone over China decreases by 16–20 ppbv in the 2050s relative to the 2010s. The ozone increase from climate change alone results in an additional 62 000 premature deaths in China as compared to 330 000 fewer premature deaths by the 2050s under a strong emissions mitigation scenario. In springtime over Southwestern China in the 2050s, the model projects 9–12 ppbv enhancements to surface ozone from the stratosphere (diagnosed with a model tracer) and from international anthropogenic emissions (diagnosed by differencing AM3 simulations with the same emissions within China but higher versus lower emissions in the rest of the world). Our findings highlight the effectiveness of emissions controls in reducing the health burden in China due to air pollution, and also the potential for climate change and rising global emissions to offset, at least partially, some of the ozone decreases attained with regional emission reductions in China.
Published: 2019
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3. Efficient droplet activation of ambient black carbon particles in a suburban environment

Author: P. Tian, D. Liu, K. Hu, Y. Wu, M. Huang, H. He, J. Sheng, C. Yu, D. Hu, and D. Ding
Subjects: Physics, QC1-999, Chemistry, QD1-999
Abstract: The cloud condensation nuclei (CCN) activity of black carbon (BC) particles importantly determines their impacts on cloud microphysics and atmospheric lifetime. This process is crucially influenced by the number of hygroscopic coating materials that BC acquire during the ageing process. It remains a challenge for ambient measurements to capture this process and link this with CCN activity of BC. Here, we directly measured the droplet activation diameter (D50) and activation fraction of BC-containing (BCc) particles (Fact,BC) in suburban Beijing using coupled measurements of size-resolved number concentrations of CCN at configured water supersaturation (SS) and BCc particles. The number concentration of BCc particles was found to peak at diameter 180–210 nm after acquiring coatings, larger than that for all particles (50–150 nm). Consequently, the initially smaller BC particles become enlarged and more hygroscopic, thereby exhibiting CCN activities than other particles. The Fact,BC increased from 42 % to 69 % in number and from 67 % to 85 % in mass as SS increased from 0.1 % to 0.2 % but tended to reach a plateau when SS > 0.2 %. Notably, Fact,BC and D50 linearly correlated with equivalent photochemical age, at a rate of +2 % h−1 and −3 nm h−1, respectively. The results suggest BCc particles from anthropogenic sources can readily serve as CCN at a relatively low SS, and more than half of the BC population can be activated within a few hours, indicating that the surface-sourced BC can efficiently incorporate into clouds and potentially exert important indirect radiative impacts.
Published: 2024
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4. The White-light Emissions in Two X-class Flares Observed by ASO-S and CHASE

Author: Ying Li, Zhichen Jing, De-Chao Song, Qiao Li, Jun Tian, Xiaofeng Liu, Ya Wang, M. D. Ding, Andrea Francesco Battaglia, Li Feng, Hui Li, and Weiqun Gan
Subjects: Solar activity, Solar flares, Solar flare spectra, Solar photosphere, Solar chromosphere, Solar x-ray emission, Astrophysics, QB460-466
Abstract: The white-light continuum emissions in solar flares (i.e., white-light flares) are usually observed on the solar disk but, in a few cases, off the limb. Here we present on-disk as well as off-limb continuum emissions at 3600 Å (in the Balmer continuum) in an X2.1 flare (SOL2023-03-03T17:52) and an X1.5 flare (SOL2023-08-07T20:46), respectively, observed by the White-light Solar Telescope on the Advanced Space-based Solar Observatory. These continuum emissions are seen at the ribbons for the X2.1 flare and on loops during the X1.5 event, in which the latter also appears in the decay phase. These emissions also show up in the pseudocontinuum images at Fe i λ 6173 from the Helioseismic and Magnetic Imager on the Solar Dynamics Observatory. In addition, the ribbon sources in the X2.1 flare exhibit significant enhancements in the Fe i line at 6569.2 Å and the nearby continuum observed by the Chinese H α Solar Explorer. It is found that the on-disk continuum emissions in the X2.1 flare are related to a nonthermal electron-beam heating either directly or indirectly, while the off-limb emissions in the X1.5 flare are associated with thermal plasma cooling or due to Thomson scattering. These comprehensive continuum observations provide good constraints on flare energy deposition models, which helps us to better understand the physical mechanism of white-light flares.
Published: 2024
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5. Various Features of the X-class White-light Flares in Super Active Region NOAA 13664

Author: Ying Li, Xiaofeng Liu, Zhichen Jing, Wei Chen, Qiao Li, Yang Su, De-Chao Song, M. D. Ding, Li Feng, Hui Li, and Weiqun Gan
Subjects: Solar activity, Solar white-light flares, Solar active regions, Solar chromosphere, Solar x-ray emission, Astrophysics, QB460-466
Abstract: Super active region NOAA 13664 produced 12 X-class flares (including the largest one so far, an occulted X8.7 flare, in solar cycle 25) during 2024 May 8–15, and 11 of them are identified as white-light flares. Here we present various features of these X-class white-light flares observed by the White-light Solar Telescope (WST) on board the Advanced Space-based Solar Observatory and the Helioseismic and Magnetic Imager (HMI) on board the Solar Dynamics Observatory. It is found that both the white-light emissions at WST 3600 Å (Balmer continuum) and HMI 6173 Å (Paschen continuum) show up in different regions of the sunspot group in these flares, including outside the sunspots and within the penumbra and umbra of the sunspots. They exhibit a point-, ribbon-, loop-, or ejecta-like shape, which can come from flare ribbons (or footpoints), flare loops, and plasma ejecta depending on the perspective view. The white-light duration and relative enhancement are measured and both parameters for 3600 Å emission have greater values than those for 6173 Å emission. It is also found that these white-light emissions are cospatial well with the hard X-ray (HXR) sources in the on-disk flares but have some offsets with the HXR emissions in the off-limb flares. In addition, it is interesting that the 3600 and 6173 Å emissions show different correlations with the peak HXR fluxes, with the former one more sensitive to the HXR emission. All these greatly help us understand the white-light flares of a large magnitude from a super active region on the Sun and also provide important insights into superflares on Sun-like stars.
Published: 2024
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6. Periodic Coronal Rain Driven by Self-consistent Heating Process in a Radiative Magnetohydrodynamic Simulation

Author: Zekun Lu, Feng Chen, J. H. Guo, M. D. Ding, Can Wang, Haocheng Yu, Y. W. Ni, and Chun Xia
Subjects: Solar corona, Solar coronal loops, Solar extreme ultraviolet emission, Solar magnetic fields, Solar active regions, Solar coronal heating, Astrophysics, QB460-466
Abstract: The periodic coronal rain and in-phase radiative intensity pulsations have been observed in multiple wavelengths in recent years. However, due to the lack of three-dimensional coronal magnetic fields and thermodynamic data in observations, it remains challenging to quantify the coronal heating rate that drives the mass cycles. In this work, based on the MURaM code, we conduct a three-dimensional radiative magnetohydrodynamic simulation spanning from the convective zone to the corona, where the solar atmosphere is heated self-consistently through dissipation resulting from magnetoconvection. For the first time, we model the periodic coronal rain in an active region. With a high spatial resolution, the simulation well resembles the observational features across different extreme-ultraviolet wavelengths. These include the realistic interweaving coronal loops, periodic coronal rain, and periodic intensity pulsations, with two periods of 3.0 hr and 3.7 hr identified within one loop system. Moreover, the simulation allows for a detailed three-dimensional depiction of coronal rain on small scales, revealing adjacent shower-like rain clumps ∼500 km in width and showcasing their multithermal internal structures. We further reveal that these periodic variations essentially reflect the cyclic energy evolution of the coronal loop under thermal nonequilibrium state. Importantly, as the driver of the mass circulation, the self-consistent coronal heating rate is considerably complex in time and space, with hour-level variations in 1 order of magnitude, minute-level bursts, and varying asymmetry reaching ten times between footpoints. This provides an instructive template for the ad hoc heating function and further enhances our understanding of the coronal heating process.
Published: 2024
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7. Global fertility in 204 countries and territories, 1950-2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021

Author: V Bhattacharjee, N, E Schumacher, A, Aali, A, Habtegiorgis Abate, Y, Abbasgholizadeh, R, Abbasian, M, Abbasi-Kangevari, M, Abbastabar, H, Abd ElHafeez, S, Abd-Elsalam, S, Abdollahi, M, Abdollahifar, M, Abdoun, M, Abdullahi, A, Abebe, M, Shawel Abebe, S, Abiodun, O, Abolhassani, H, Abolmaali, M, Abouzid, M, Beressa Aboye, G, Guimarães Abreu, L, Aberhe Abrha, W, M Abrigo, M, Abtahi, D, Abualruz, H, Abubakar, B, Abu-Gharbieh, E, Me Abu-Rmeileh, N, Girum Girum Adal, T, Molla Adane, M, Atanda Adeagbo Adeagbo, O, Adesoji Adedoyin, R, Adekanmbi, V, Aden, B, Victor Adepoju, A, O Adetokunboh, O, Bunmi Adetunji, J, Adedayo Adeyinka, D, Israel Adeyomoye, O, Estiningtyas Sakilah Adnani, Q, Adra, S, Felix Afolabi, R, Afyouni, S, Sohail Afzal, M, Afzal, S, Aghamiri, S, Agodi, A, Agyemang-Duah, W, Opoku Ahinkorah, B, J Ahlstrom, A, Ahmad, A, Ahmad, D, Ahmad, F, M Ahmad, M, Ahmad, S, Ahmad, T, Ahmed, A, Ahmed, H, A Ahmed, L, Saleh Ahmed, M, Anees Ahmed, S, Ajami, M, Aji, B, Taddesse Akalu, G, Akbarialiabad, H, Olusola Akinyemi, R, Ahmed Akkaif, M, Akkala, S, Al Hamad, H, Mahfuz Al Hasan, S, Al Qadire, M, Mohammed Ali Al-Ahdal, T, O Alalalmeh, S, A Alalwan, T, Al-Aly, Z, Alam, K, Mustafa Al-Amer, R, Mashhour Alanezi, F, M Alanzi, T, Albakri, A, Albashtawy, M, T AlBataineh, M, Alemi, H, Alemi, S, Mulugeta Alemu, Y, Al-Eyadhy, A, Ali Saeed Al-Gheethi, A, F Alhabib, K, Alhajri, N, Alhalaiqa Naji Alhalaiqa, F, Kaba Alhassan, R, Ali, A, Abdulqadir Ali, B, Ali, L, Usman Ali, M, Ali, R, Shujait Shujait Ali, S, Mohammad Alif, S, Aligol, M, Alijanzadeh, M, M Aljasir, M, Mohamed Aljunid, S, Al-Marwani, S, Uy Almazan, J, M Al-Mekhlafi, H, Almidani, O, A Alomari, M, Al-Omari, B, S Alqahtani, J, Yaseen Alqutaibi, A, M Al-Raddadi, R, Khalifah Al-Sabah, S, Altaf, A, A Al-Tawfiq, J, A Altirkawi, K, Oyine Aluh, D, Jawad Alvi, F, Alvis-Guzman, N, Alwafi, H, Mohammed Al-Worafi, Y, Aly, H, Aly, S, H Alzoubi, K, Kwabena Ameyaw, E, Tawfik Amin, T, Amindarolzarbi, A, Amini-Rarani, M, Amiri, S, Gyamfuah Ampomah, I, A Amugsi, D, Adeniyi Amusa, G, Ancuceanu, R, Anderlini, D, Prata Andrade, P, Liliana Andrei, C, Andrei, T, Anil, A, Anil, S, Ansar, A, Ansari-Moghaddam, A, M Antony, C, Antriyandarti, E, Anvari, S, Anwar, S, Anwer, R, Edward Anyasodor, A, Arabloo, J, Arabzadeh Bahri, R, A Arafa, E, Arafat, M, Margarida Araújo, A, Y Aravkin, A, Aremu, A, Aripov, T, Arkew, M, Armocida, B, Ärnlöv, J, Arooj, M, A Artamonov, A, Arulappan, J, Taiwo Aruleba, R, Arumugam, A, Asadi-Lari, M, Asemi, Z, Asgary, S, Asghariahmadabad, M, Asghari-Jafarabadi, M, Yesse Ashemo, M, Ashraf, M, Ashraf, T, O Asika, M, Shamsadin Athari, S, Moh'd Wahbi Atout, M, Atreya, A, Aujayeb, A, Ausloos, M, Avan, A, Mulat Aweke, A, Melaku Ayele, G, Mohammad Ayyoubzadeh, S, Azadnajafabad, S, S Azevedo, R, Y Azzam, A, Badar, M, D Badiye, A, Baghdadi, S, Bagheri, N, Bagherieh, S, Bahmanziari, N, Bai, R, Amin Baig, A, L Baker, J, T Bako, A, Kaur Bakshi, R, Balasubramanian, M, Constantin Baltatu, O, Bam, K, Banach, M, Bandyopadhyay, S, Banik, B, Chandra Banik, P, Bansal, H, Firat Baran, M, Barchitta, M, Bardhan, M, Bardideh, E, Lyn Barker-Collo, S, Winfried Bärnighausen, T, Barone-Adesi, F, Jawdat Barqawi, H, Barrow, A, Barteit, S, Basharat, Z, J Bashir, A, Akande Bashiru, H, Basiru, A, Diogo Basso, J, Basu, S, Mohammad Batiha, A, Batra, K, T Baune, B, Bayati, M, Begum, T, Behboudi, E, Hossein Behnoush, A, Beiranvand, M, Fernanda Bejarano Ramirez, D, Bekele, A, Assefa Belay, S, Iqbal Belgaumi, U, L Bell, M, Omolaja Bello, O, Beloukas, A, M Bensenor, I, Berezvai, Z, Yirga Berhie, A, C Bermudez, A, G Bettencourt, P, Srikanth Bhagavathula, A, Bhardwaj, N, Bhardwaj, P, V Bhardwaj, P, Bhaskar, S, Bhat, V, Kaur Bhatti, G, Singh Bhatti, J, S Bhatti, M, Bhatti, R, Biondi, A, Bisignano, C, Biswas, A, Kishore Biswas, R, R Bitra, V, Bjørge, T, Bliss, E, Kofi Boachie, M, Vasilica Bobirca, A, Bodolica, V, Olalekan Bodunrin, A, Ketema Bogale, E, Angaw Bogale, K, Bonakdar Hashemi, M, Bora Basara, B, Bouaoud, S, Braithwaite, D, Brauer, M, K Breitborde, N, Bryazka, D, B Bulamu, N, Buonsenso, D, Burkart, K, A Burns, R, Bustanji, Y, Shafique Butt, N, A Butt, Z, Luciano Caetano Dos Santos, F, Calina, D, R Campos-Nonato, I, Cao, F, Cao, S, Capodici, A, Carreras, G, Carugno, A, A Castañeda-Orjuela, C, Castelpietra, G, Sofia Cattaruzza, M, Caye, A, Cegolon, L, Cembranel, F, Cerin, E, Chadwick, J, Chahine, Y, Chakraborty, C, Chalek, J, Shi Kai Chan, J, Charalampous, P, Kumar Chattu, V, Chaturvedi, S, Paul Chavula, M, Chen, A, Chen, H, Chen, S, Chi, G, Chichagi, F, Chien, J, R Ching, P, S Cho, W, Choi, S, Chong, B, Chopra, H, Gajanan Choudhari, S, J Christopher, D, Chu, D, Sunday Chukwu, I, Chung, E, Chung, S, Cindi, Z, Cioffi, I, Ciuffreda, R, M Claro, R, Coberly, K, Columbus, A, Comfort, H, Conde, J, H Criqui, M, Cruz-Martins, N, Magali Cuadra-Hernández, S, Dadana, S, Dadras, O, Dahiru, T, Dai, Z, Dalton, B, Damiani, G, Mohammad Darwesh, A, K Das, J, Das, S, Dashti, M, Dastiridou, A, Alberto Dávila-Cervantes, C, Davletov, K, Tamire Debele, A, Debopadhaya, S, Delavari, S, Delgado-Enciso, I, Demeke, D, Hundessa Demessa, B, Deng, X, Denova-Gutiérrez, E, Deribe, K, Dervenis, N, Dineshbhai Desai, H, Desai, R, Gnana Chellaiyan Devanbu, V, Dhali, A, Dhama, K, Dhimal, M, R Dhulipala, V, Dias da Silva, D, Diaz, D, J Diaz, M, Dima, A, D Ding, D, Ashworth Dirac, M, Chi Do, T, Huynh Phuong Do, T, Bruneli do Prado, C, Dohare, S, Dong, W, D'Oria, M, Mombaque Dos Santos, W, Doshmangir, L, Kokou Dowou, R, Chelsea Dsouza, A, Larson Dsouza, H, Dsouza, V, Dube, J, Duprey, J, Rodrigues Duraes, A, Duraisamy, S, Christopher Durojaiye, O, Dutta, S, Dwyer-Lindgren, L, Agnieszka Dzianach, P, Marian Dziedzic, A, Ebrahimi, A, Atan Edinur, H, Edvardsson, K, Efendi, F, Andreas Eikemo, T, Ekholuenetale, M, El Tantawi, M, Mousaad Elemam, N, Metwally Tawfik ElGohary, G, Elhadi, M, Tesfaye Elilo, L, Abdelsadek Abdou Elmeligy, O, A Elmonem, M, Elshaer, M, Elsohaby, I, Emami Zeydi, A, Engelbert Bain, L, Eskandarieh, S, Esposito, F, Estep, K, Etaee, F, Fabin, N, Francis Fagbamigbe, A, Fahimi, S, Fakhri-Demeshghieh, A, Falzone, L, Faramarzi, A, Ezzat Mahmoud Faris, M, Farmer, S, Faro, A, Omolara Fasanmi, A, Fatehizadeh, A, Klau Fauk, N, Fazeli, P, L Feigin, V, Fereshtehnejad, S, Hamid Feroze, A, Ferrara, P, Ferreira, N, Fetensa, G, Filip, I, Fischer, F, Flavel, J, A Foigt, N, Oluwatoyin Folayan, M, Alekseevich Fomenkov, A, Foroutan, B, Foschi, M, Raphael Fowobaje, K, Louise Francis, K, Freitas, A, Fukumoto, T, E Fuller, J, Fux, B, Andras Gaal, P, A Gadanya, M, Motiramji Gaidhane, A, Galali, Y, Gallus, S, P Gandhi, A, Ganesan, B, Arfat Ganiyani, M, A Garcia-Gordillo, M, Garg, N, K Gautam, R, Gazzelloni, F, Olatunde Gbadamosi, S, W Gebregergis, M, Gebrehiwot, M, Brhane Gebremariam, T, B Gebremariam, T, Gebru Gebremeskel, T, Fikadu Geda, Y, Roxana Georgescu, S, Gerema, U, Geremew, H, Erena Getachew, M, W Gething, P, Ghasemi, M, Ghasempour Dabaghi, G, Ghasemzadeh, A, Ghassemi, F, Mohamed Ghazy, R, Ghimire, S, Gholamian, A, Gholamrezanezhad, A, Ghorbani, M, Gopal Ghoshal, A, Digambarrao Ghuge, A, Urievich Gil, A, K Gill, T, Giorgi, M, Girmay, A, C Glasbey, J, Göbölös, L, Goel, A, Golchin, A, Golechha, M, Goleij, P, Vali Gopalani, S, Goudarzi, H, C Goulart, A, Goyal, A, Matthew Graham, S, Grivna, M, Guan, S, Guarducci, G, Ibrahim Mohialdeen Gubari, M, Dechasa Gudeta, M, Guicciardi, S, Gulati, S, Gulisashvili, D, Asanga Gunawardane, D, Guo, C, Kumar Gupta, A, Gupta, B, Kumar Gupta, M, Gupta, M, Gupta, S, Bala Gupta, V, Kumar Gupta, V, Haakenstad, A, Habibzadeh, F, R Hadi, N, Haep, N, Hajibeygi, R, Haller, S, Halwani, R, R Hamadeh, R, M Hamdy, N, Hameed, S, Hamidi, S, Han, Q, J Handal, A, J Hankey, G, Nuruzzaman Haque, M, Maria Haro, J, I Hasaballah, A, Hasan, I, Jahid Hasan, M, M Mahmudul Hasan, S, Hasani, H, Saquib Hasnain, M, Hassan, A, Hassan, I, Hassanipour, S, Hassankhani, H, I Hay, S, J Hebert, J, E Hegazi, O, Heidari, M, Helfer, B, Hemmati, M, Yuliana Herrera-Serna, B, Herteliu, C, Hessami, K, Hezam, K, Hiraike, Y, Quoc Hoan, N, Holla, R, Horita, N, Mahbub Hossain, M, Bellal Hossain Hossain, M, Hosseinzadeh, H, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Hsairi, M, Chia-Rong Hsieh, V, Hu, C, Huang, J, Mamun Huda, M, Humayun, A, Hussain, J, R Hussein, N, Huynh, H, Hwang, B, Emmanuel Ibitoye, S, Maria Iftikhar, P, Stephen Ilesanmi, O, M Ilic, I, D Ilic, M, Immurana, M, Raja Inbaraj, L, Iqbal, A, Rabiul Islam, M, Elkudssiah Ismail, N, Iso, H, Isola, G, Iwagami, M, Iyer, M, J, L, Jaafari, J, Jacob, L, Jadidi-Niaragh, F, Jaggi, K, Jahankhani, K, Jahanmehr, N, Jahrami, H, Jain, A, Jain, N, Abdulrahman Jairoun, A, Jakovljevic, M, Jamshidi, E, Javadov, S, Javaheri, T, Kumar Jayapal, S, Jayaram, S, Ha Jee, S, Jeganathan, J, K Jha, A, Prakash Jha, R, Jiang, H, Jokar, M, B Jonas, J, Joo, T, Joseph, N, Ehimwenma Joshua, C, Joukar, F, Jerzy Jozwiak, J, Jürisson, M, K, V, Kaambwa, B, Kabir, A, Kabir, H, Kabir, Z, Kalani, R, R Kalankesh, L, Kaliyadan, F, Kalra, S, Kamath, R, Kamath, S, Kanchan, T, Wedam Kanmiki, E, Kazeem Kanmodi, K, S, S, Kumar Kansal, S, S Kantar, R, Kapoor, N, Karajizadeh, M, Karami, M, M Karaye, I, Zaffar Kashoo, F, Kasraei, H, J Kassebaum, N, B Kassel, M, H Kauppila, J, Kazemi, F, Kazeminia, S, H Kempen, J, Shoshannah Kendal, E, Keshtkar, K, Keykhaei, M, Khajuria, H, Khalaji, A, Khalid, N, Ahmed Khalil, A, Khalilian, A, Khamesipour, F, Khan, A, Khan, I, Nuruzzaman Khan, M, Khan, M, Jobair Khan, M, Ab Khan, M, Khang, Y, Khanmohammadi, S, Khatab, K, Khavandegar, A, Reza Khayat Kashani, H, Fatima Khidri, F, Khormali, M, Ali Khosravi, M, Khosrowjerdi, M, Teklesilasie Kidane, W, Demelash Kifle, Z, Sojin Kim, J, Seo Kim, M, W Kimokoti, R, E Kinzel, K, Tsegay Kiross, G, Kisa, A, Kisa, S, Kolahi, A, Kompani, F, Koren, G, Korzh, O, Kosen, S, Lakshmi Koulmane Laxminarayana, S, Krishan, K, Krishna, V, Krishnamoorthy, V, Kuate Defo, B, M Kubeisy, C, Kucuk Bicer, B, Abdul Kuddus, M, Kuddus, M, Kuitunen, I, Kulimbet, M, Kumar, H, Kundu, S, Rotimi Kunle, K, P Kurmi, O, Kusnali, A, Kusuma, D, F Kyei, E, Kyriopoulos, I, La Vecchia, C, Lacey, B, Awwal Ladan, M, Laflamme, L, Lahariya, C, Teck Ching Lai, D, Kumar Lal, D, Lalloo, R, Lám, J, Lamnisos, D, Landires, I, Lanfranchi, F, Langguth, B, Laplante-Lévesque, A, Jane Larson, H, O Larsson, A, Lasrado, S, Latief, K, Latifinaibin, K, Khanh Dao Le, L, Huu Hanh Le, N, Diep Thanh Le, T, Ledda, C, Lee, M, H Lee, P, Won Lee, S, Han Lee, Y, Kiros Lema, G, Leong, E, L Lerango, T, Li, A, Li, M, Li, S, Li, W, Li, X, S Ligade, V, S Lim, S, Lin, R, A Lindstedt, P, Listl, S, Liu, G, Liu, J, Liu, X, Liu, Y, Llanaj, E, López-Bueno, R, D Lopukhov, P, Lorenzovici, L, A Lotufo, P, Lubinda, J, Lucchetti, G, Lugo, A, Lunevicius, R, Lv, H, Feei Ma, Z, Lynn Maass, K, Machoy, M, M Madureira-Carvalho, Á, Magdy Abd El Razek, M, A Maghazachi, A, Mahjoub, S, Adam Mahmoud, M, Majeed, A, N Malagón-Rojas, J, Malakan Rad, E, Malhotra, K, Azam Malik, A, Malik, I, 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Hay, Jeffrey J Hebert, Omar E Hegazi, Mohammad Heidari, Bartosz Helfer, Mehdi Hemmati, Brenda Yuliana Herrera-Serna, Claudiu Herteliu, Kamran Hessami, Kamal Hezam, Yuta Hiraike, Nguyen Quoc Hoan, Ramesh Holla, Nobuyuki Horita, Md Mahbub Hossain, Mohammad Bellal Hossain Hossain, Hassan Hosseinzadeh, Mehdi Hosseinzadeh, Mihaela Hostiuc, Sorin Hostiuc, Mohamed Hsairi, Vivian Chia-Rong Hsieh, Chengxi Hu, Junjie Huang, M Mamun Huda, Ayesha Humayun, Javid Hussain, Nawfal R Hussein, Hong-Han Huynh, Bing-Fang Hwang, Segun Emmanuel Ibitoye, Pulwasha Maria Iftikhar, Olayinka Stephen Ilesanmi, Irena M Ilic, Milena D Ilic, Mustapha Immurana, Leeberk Raja Inbaraj, Afrin Iqbal, Md Rabiul Islam, Nahlah Elkudssiah Ismail, Hiroyasu Iso, Gaetano Isola, Masao Iwagami, Mahalaxmi Iyer, Linda Merin J, Jalil Jaafari, Louis Jacob, Farhad Jadidi-Niaragh, Khushleen Jaggi, Kasra Jahankhani, Nader Jahanmehr, Haitham Jahrami, Akhil Jain, Nityanand Jain, Ammar Abdulrahman Jairoun, Mihajlo Jakovljevic, Elham Jamshidi, Sabzali Javadov, Tahereh Javaheri, Sathish Kumar Jayapal, Shubha Jayaram, Sun Ha Jee, Jayakumar Jeganathan, Anil K Jha, Ravi Prakash Jha, Heng Jiang, Mohammad Jokar, Jost B Jonas, Tamas Joo, Nitin Joseph, Charity Ehimwenma Joshua, Farahnaz Joukar, Jacek Jerzy Jozwiak, Mikk Jürisson, Vaishali K, Billingsley Kaambwa, Abdulkareem Kabir, Ali Kabir, Hannaneh Kabir, Zubair Kabir, Rizwan Kalani, Leila R Kalankesh, Feroze Kaliyadan, Sanjay Kalra, Rajesh Kamath, Sagarika Kamath, Tanuj Kanchan, Edmund Wedam Kanmiki, Kehinde Kazeem Kanmodi, Suthanthira Kannan S, Sushil Kumar Kansal, Rami S Kantar, Neeti Kapoor, Mehrdad Karajizadeh, Manoochehr Karami, Ibraheem M Karaye, Faizan Zaffar Kashoo, Hengameh Kasraei, Nicholas J Kassebaum, Molly B Kassel, Joonas H Kauppila, Foad Kazemi, Sara Kazeminia, John H Kempen, Evie Shoshannah Kendal, Kamyab Keshtkar, Mohammad Keykhaei, Himanshu Khajuria, Amirmohammad Khalaji, Nauman Khalid, Anees Ahmed Khalil, Alireza Khalilian, Faham Khamesipour, Ajmal Khan, Asaduzzaman Khan, Ikramullah Khan, M Nuruzzaman Khan, Maseer Khan, Mohammad Jobair Khan, Moien Ab Khan, Young-Ho Khang, Shaghayegh Khanmohammadi, Khaled Khatab, Armin Khavandegar, Hamid Reza Khayat Kashani, Feriha Fatima Khidri, Moein Khormali, Mohammad Ali Khosravi, Mahmood Khosrowjerdi, Wondwosen Teklesilasie Kidane, Zemene Demelash Kifle, Julie Sojin Kim, Min Seo Kim, Ruth W Kimokoti, Kasey E Kinzel, Girmay Tsegay Kiross, Adnan Kisa, Sezer Kisa, Ali-Asghar Kolahi, Farzad Kompani, Gerbrand Koren, Oleksii Korzh, Soewarta Kosen, Sindhura Lakshmi Koulmane Laxminarayana, Kewal Krishan, Varun Krishna, Vijay Krishnamoorthy, Barthelemy Kuate Defo, Connor M Kubeisy, Burcu Kucuk Bicer, Md Abdul Kuddus, Mohammed Kuddus, Ilari Kuitunen, Mukhtar Kulimbet, Harish Kumar, Satyajit Kundu, Kunle Rotimi Kunle, Om P Kurmi, Asep Kusnali, Dian Kusuma, Evans F Kyei, Ilias Kyriopoulos, Carlo La Vecchia, Ben Lacey, Muhammad Awwal Ladan, Lucie Laflamme, Chandrakant Lahariya, Daphne Teck Ching Lai, Dharmesh Kumar Lal, Ratilal Lalloo, Judit Lám, Demetris Lamnisos, Iván Landires, Francesco Lanfranchi, Berthold Langguth, Ariane Laplante-Lévesque, Heidi Jane Larson, Anders O Larsson, Savita Lasrado, Kamaluddin Latief, Kaveh Latifinaibin, Long Khanh Dao Le, Nhi Huu Hanh Le, Trang Diep Thanh Le, Caterina Ledda, Munjae Lee, Paul H Lee, Seung Won Lee, Yo Han Lee, Gebretsadik Kiros Lema, Elvynna Leong, Temesgen L Lerango, An Li, Ming-Chieh Li, Shanshan Li, Wei Li, Xiaopan Li, Virendra S Ligade, Stephen S Lim, Ro-Ting Lin, Paulina A Lindstedt, Stefan Listl, Gang Liu, Jue Liu, Xiaofeng Liu, Xuefeng Liu, Yuewei Liu, Erand Llanaj, Rubén López-Bueno, Platon D Lopukhov, László Lorenzovici, Paulo A Lotufo, Jailos Lubinda, Giancarlo Lucchetti, Alessandra Lugo, Raimundas Lunevicius, Hengliang Lv, Zheng Feei Ma, Kelsey Lynn Maass, Monika Machoy, Áurea M Madureira-Carvalho, Mohammed Magdy Abd El Razek, Azzam A Maghazachi, Soleiman Mahjoub, Mansour Adam Mahmoud, Azeem Majeed, Jeadran N Malagón-Rojas, Elaheh Malakan Rad, Kashish Malhotra, Ahmad Azam Malik, Iram Malik, Deborah Carvalho Malta, Abdullah A Mamun, Yosef Manla, Yasaman Mansoori, Ali Mansour, Borhan Mansouri, Zeinab Mansouri, Mohammad Ali Mansournia, Joemer C Maravilla, Mirko Marino, Abdoljalal Marjani, Gabriel Martinez, Ramon Martinez-Piedra, Francisco Rogerlândio Martins-Melo, Miquel Martorell, Sharmeen Maryam, Roy Rillera Marzo, Alireza Masoudi, Jishanth Mattumpuram, Richard James Maude, Andrea Maugeri, Erin A May, Mahsa Mayeli, Maryam Mazaheri, John J McGrath, Martin McKee, Anna Laura Wensel McKowen, Susan A McLaughlin, Steven M McPhail, Rahul Mehra, Kamran Mehrabani-Zeinabad, Entezar Mehrabi Nasab, Tesfahun Mekene Meto, Max Alberto Mendez Mendez-Lopez, Walter Mendoza, Ritesh G Menezes, George A Mensah, Alexios-Fotios A Mentis, Sultan Ayoub Meo, Mohsen Merati, Atte Meretoja, Tuomo J Meretoja, Abera M Mersha, Tomislav Mestrovic, Pouya Metanat, Kukulege Chamila Dinushi Mettananda, Sachith Mettananda, Adquate Mhlanga, Laurette Mhlanga, Tianyue Mi, Tomasz Miazgowski, Georgia Micha, Irmina Maria Michalek, Ted R Miller, Le Huu Nhat Minh, Mojgan Mirghafourvand, Erkin M Mirrakhimov, Mizan Kiros Mirutse, Moonis Mirza, Roya Mirzaei, Ashim Mishra, Sanjeev Misra, Philip B Mitchell, Chaitanya Mittal, Babak Moazen, Abdalla Z Mohamed, Ahmed Ismail Mohamed, Jama Mohamed, Mouhand F H Mohamed, Nouh Saad Mohamed, Sakineh Mohammad-Alizadeh-Charandabi, Soheil Mohammadi, Abdollah Mohammadian-Hafshejani, Mustapha Mohammed, Salahuddin Mohammed, Shafiu Mohammed, Ali H Mokdad, Peyman Mokhtarzadehazar, Hossein Molavi Vardanjani, Sabrina Molinaro, Lorenzo Monasta, Mohammad Ali Moni, Maryam Moradi, Yousef Moradi, Paula Moraga, Rafael Silveira Moreira, Negar Morovatdar, Shane Douglas Morrison, Jakub Morze, Abbas Mosapour, Elias Mossialos, Rohith Motappa, Parsa Mousavi, Amin Mousavi Khaneghah, Christine Mpundu-Kaambwa, Sumaira Mubarik, Lorenzo Muccioli, Francesk Mulita, Kavita Munjal, Efrén Murillo-Zamora, Jonah Musa, Fungai Musaigwa, Ana-Maria Musina, Sathish Muthu, Saravanan Muthupandian, Muhammad Muzaffar, Woojae Myung, Ahamarshan Jayaraman Nagarajan, Gabriele Nagel, Pirouz Naghavi, Ganesh R Naik, Gurudatta Naik, Mukhammad David Naimzada, Firzan Nainu, Vinay Nangia, Sreenivas Narasimha Swamy, Bruno Ramos Nascimento, Gustavo G Nascimento, Abdallah Y Naser, Mohammad Javad Nasiri, Zuhair S Natto, Javaid Nauman, Muhammad Naveed, Biswa Prakash Nayak, Vinod C Nayak, Rawlance Ndejjo, Sabina Onyinye Nduaguba, Hadush Negash, Chernet Tafere Negesse, Ionut Negoi, Ruxandra Irina Negoi, Seyed Aria Nejadghaderi, Chakib Nejjari, Samata Nepal, Henok Biresaw Netsere, Georges Nguefack-Tsague, Josephine W Ngunjiri, Dang H Nguyen, Hau Thi Hien Nguyen, Phuong The Nguyen, QuynhAnh P Nguyen, Van Thanh Nguyen, Robina Khan Niazi, Yeshambel T Nigatu, Taxiarchis Konstantinos Nikolouzakis, Ali Nikoobar, Amin Reza Nikpoor, Chukwudi A Nnaji, Lawrence Achilles Nnyanzi, Efaq Ali Noman, Shuhei Nomura, Mamoona Noreen, Nafise Noroozi, Chisom Adaobi Nri-Ezedi, Mengistu H Nunemo, Virginia Nuñez-Samudio, Dieta Nurrika, Jerry John Nutor, Bogdan Oancea, Kehinde O Obamiro, Ismail A Odetokun, Nkechi Martina Odogwu, Martin James O'Donnell, Oluwakemi Ololade Odukoya, Ayodipupo Sikiru Oguntade, James Odhiambo Oguta, In-Hwan Oh, Sylvester Reuben Okeke, Akinkunmi Paul Okekunle, Osaretin Christabel Okonji, Patrick Godwin Okwute, Andrew T Olagunju, Omotola O Olasupo, Matthew Idowu Olatubi, Gláucia Maria Moraes Oliveira, Bolajoko Olubukunola Olusanya, Jacob Olusegun Olusanya, Gideon Olamilekan Oluwatunase, Hany A Omar, Goran Latif Omer, Obinna E Onwujekwe, Michal Ordak, Orish Ebere Orisakwe, Verner N Orish, Doris V Ortega-Altamirano, Alberto Ortiz, Esteban Ortiz-Prado, Wael M S Osman, Uchechukwu Levi Osuagwu, Olayinka Osuolale, Adrian Otoiu, Stanislav S Otstavnov, Amel Ouyahia, Guoqing Ouyang, Mayowa O Owolabi, Yaz Ozten, Mahesh Padukudru P A, Mohammad Taha Pahlevan Fallahy, Feng Pan, Hai-Feng Pan, Adrian Pana, Paramjot Panda, Songhomitra Panda-Jonas, Helena Ullyartha Pangaribuan, Georgios D Panos, Leonidas D Panos, Ioannis Pantazopoulos, Anca Mihaela Pantea Stoian, Romil R Parikh, Seoyeon Park, Ashwaghosha Parthasarathi, Ava Pashaei, Roberto Passera, Hemal M Patel, Jay Patel, Shankargouda Patil, Dimitrios Patoulias, Venkata Suresh Patthipati, Uttam Paudel, Mihaela Paun, Hamidreza Pazoki Toroudi, Spencer A Pease, Amy E Peden, Paolo Pedersini, Minjin Peng, Umberto Pensato, Veincent Christian Filipino Pepito, Prince Peprah, Gavin Pereira, Mario F P Peres, Arokiasamy Perianayagam, Norberto Perico, Simone Perna, Richard G Pestell, Fanny Emily Petermann-Rocha, Hoang Tran Pham, Anil K Philip, Daniela Pierannunzio, Manon Pigeolet, David M Pigott, Evgenii Plotnikov, Dimitri Poddighe, Peter Pollner, Ramesh Poluru, Maarten J Postma, Ghazaleh Pourali, Akram Pourshams, Naeimeh Pourtaheri, Disha Prabhu, Sergio I Prada, Pranil Man Singh Pradhan, Manya Prasad, Akila Prashant, Bharathi M Purohit, Jagadeesh Puvvula, Nameer Hashim Qasim, Ibrahim Qattea, Deepthi R, Mehrdad Rabiee Rad, Amir Radfar, Venkatraman Radhakrishnan, Pourya Raee, Hadi Raeisi Shahraki, Alireza Rafiei, Seyedeh Niloufar Rafiei Alavi, Cat Raggi, Pankaja Raghav Raghav, Fakher Rahim, Md Jillur Rahim, Md Mosfequr Rahman, Mohammad Hifz Ur Rahman, Mosiur Rahman, Muhammad Aziz Rahman, Vahid Rahmanian, Masoud Rahmati, Niloufar Rahnavard, Pramila Rai, Diego Raimondo, Ali Rajabpour-Sanati, Prashant Rajput, Prasanna Ram, Shakthi Kumaran Ramasamy, Juwel Rana, Kritika Rana, Shailendra Singh Rana, Chhabi Lal Ranabhat, Nemanja Rancic, Amey Rane, Shubham Ranjan, Chythra R Rao, Indu Ramachandra Rao, Deepthi Rapaka, Davide Rasella, Sina Rashedi, Vahid Rashedi, Mohammad-Mahdi Rashidi, Azad Rasul, Zubair Ahmed Ratan, Giridhara Rathnaiah Babu, Santosh Kumar Rauniyar, Nakul Ravikumar, David Laith Rawaf, Salman Rawaf, Reza Rawassizadeh, Bharat Rawlley, Murali Mohan Rama Krishna Reddy, Elrashdy Moustafa Mohamed Redwan, Giuseppe Remuzzi, Bhageerathy Reshmi, Nazila Rezaei, Aida Rezaei Nejad, Mohsen Rezaeian, Abanoub Riad, Mavra A Riaz, Jennifer Rickard, Reza Rikhtegar, Hannah Elizabeth Robinson-Oden, Célia Fortuna Rodrigues, Jefferson Antonio Buendia Rodriguez, Ravi Rohilla, Debby Syahru Romadlon, Luca Ronfani, Himanshu Sekhar Rout, Bedanta Roy, Nitai Roy, Priyanka Roy, Enrico Rubagotti, Guilherme de Andrade Ruela, Susan Fred Rumisha, Tilleye Runghien, Manjula S, Chandan S N, Aly M A Saad, Zahra Saadatian, Maha Mohamed Saber-Ayad, Morteza SaberiKamarposhti, Siamak Sabour, Fatos Sada, Basema Saddik, Bashdar Abuzed Sadee, Ehsan Sadeghi, Erfan Sadeghi, Mohammad Reza Saeb, Umar Saeed, Sher Zaman Safi, Dominic Sagoe, Manika Saha, Amirhossein Sahebkar, Soumya Swaroop Sahoo, Monalisha Sahu, Zahra Saif, Joseph W Sakshaug, Payman Salamati, Afeez Abolarinwa Salami, Mohamed A Saleh, Marwa Rashad Salem, Mohammed Z Y Salem, Sohrab Salimi, Sara Samadzadeh, Yoseph Leonardo Samodra, Vijaya Paul Samuel, Abdallah M Samy, Juan Sanabria, Nima Sanadgol, Francesca Sanna, Milena M Santric-Milicevic, Haaris Saqib, Sivan Yegnanarayana Iyer Saraswathy, Aswini Saravanan, Babak Saravi, Yaser Sarikhani, Tanmay Sarkar, Rodrigo Sarmiento-Suárez, Gargi Sachin Sarode, Sachin C Sarode, Arash Sarveazad, Brijesh Sathian, Thirunavukkarasu Sathish, Anudeep Sathyanarayan, Abu Sayeed, Md Abu Sayeed, Nikolaos Scarmeas, Winfried Schlee, Art Schuermans, David C Schwebel, Falk Schwendicke, Siddharthan Selvaraj, Pallav Sengupta, Subramanian Senthilkumaran, Sadaf G Sepanlou, Dragos Serban, Edson Serván-Mori, Yashendra Sethi, SeyedAhmad SeyedAlinaghi, Seyed Arsalan Seyedi, Allen Seylani, Mahan Shafie, Jaffer Shah, Pritik A Shah, Ataollah Shahbandi, Samiah Shahid, Moyad Jamal Shahwan, Ahmed Shaikh, Masood Ali Shaikh, Muhammad Aaqib Shamim, Mehran Shams-Beyranvand, Mohammad Anas Shamsi, Mohd Shanawaz, Abhishek Shankar, Mohammed Shannawaz, Medha Sharath, Sadaf Sharfaei, Amin Sharifan, Javad Sharifi-Rad, Manoj Sharma, Rajesh Sharma, Ujjawal Sharma, Vishal Sharma, Rajesh P Shastry, Amin Shavandi, David H Shaw, Amir Mehdi Shayan, Maryam Shayan, Amr Mohamed Elsayed Shehabeldine, Aziz Sheikh, Rahim Ali Sheikhi, Manjunath Mala Shenoy, Pavanchand H Shetty, Peilin Shi, Desalegn Shiferaw, Mika Shigematsu, Rahman Shiri, Reza Shirkoohi, Aminu Shittu, Velizar Shivarov, Farhad Shokraneh, Sina Shool, Seyed Afshin Shorofi, Kanwar Hamza Shuja, Kerem Shuval, Emmanuel Edwar Siddig, João Pedro Silva, Luís Manuel Lopes Rodrigues Silva, Soraia Silva, Biagio Simonetti, Anjali Singal, Abhinav Singh, Balbir Bagicha Singh, Jasvinder A Singh, Md Shahjahan Siraj, Georgia Smith, Bogdan Socea, Anton Sokhan, Ranjan Solanki, Shipra Solanki, Hamidreza Soleimani, Sameh S M Soliman, Yonatan Solomon, Yimeng Song, Reed J D Sorensen, Michael Spartalis, Chandrashekhar T Sreeramareddy, Vijay Kumar Srivastava, Muhammad Haroon Stanikzai, Vladimir I Starodubov, Antonina V Starodubova, Simona Cătălina Stefan, Paschalis Steiropoulos, Mark A Stokes, Vetriselvan Subramaniyan, Muhammad Suleman, Rizwan Suliankatchi Abdulkader, Abida Sultana, Jing Sun, Chandan Kumar Swain, Bryan L Sykes, Lukasz Szarpak, Mindy D Szeto, Miklós Szócska, Payam Tabaee Damavandi, Rafael Tabarés-Seisdedos, Ozra Tabatabaei Malazy, Seyed-Amir Tabatabaeizadeh, Shima Tabatabai, Karen M Tabb, Mohammad Tabish, Moslem Taheri Soodejani, Jabeen Taiba, Ardeshir Tajbakhsh, Iman M Talaat, Ashis Talukder, Mircea Tampa, Jacques Lukenze Tamuzi, Ker-Kan Tan, Haosu Tang, Derbie Alemu DA Tareke, Mengistie Kassahun Tariku, Vivian Y Tat, Seyed Mohammad Tavangar, Mojtaba Teimoori, Mohamad-Hani Temsah, Reem Mohamad Hani Temsah, Masayuki Teramoto, Dufera Rikitu Terefa, Riki Tesler, Enoch Teye-Kwadjo, Ramna Thakur, Pugazhenthan Thangaraju, Kavumpurathu Raman Thankappan, Rekha Thapar, Samar Tharwat, Rasiah Thayakaran, Nihal Thomas, Ales Tichopad, Jansje Henny Vera Ticoalu, Tenaw Yimer Tiruye, Mariya Vladimirovna Titova, Marcello Tonelli, Marcos Roberto Tovani-Palone, Eugenio Traini, Jasmine T Tran, Nghia Minh Tran, Indang Trihandini, Samuel Joseph Tromans, Thien Tan Tri Tai Truyen, Aristidis Tsatsakis, Evangelia Eirini Tsermpini, Munkhtuya Tumurkhuu, Stefanos Tyrovolas, Sayed Mohammad Nazim Uddin, Aniefiok John Udoakang, Arit Udoh, Atta Ullah, Saeed Ullah, Sana Ullah, Srikanth Umakanthan, Chukwuma David Umeokonkwo, Brigid Unim, Bhaskaran Unnikrishnan, Era Upadhyay, Jibrin Sammani Usman, Marco Vacante, Seyed Mohammad Vahabi, Asokan Govindaraj Vaithinathan, Rohollah Valizadeh, Jef Van den Eynde, Elena Varavikova, Orsolya Varga, Priya Vart, Shoban Babu Varthya, Tommi Juhani Vasankari, Balachandar Vellingiri, Deneshkumar Venugopal, Nicholas Alexander Verghese, Madhur Verma, Massimiliano Veroux, Georgios-Ioannis Verras, Dominique Vervoort, Jorge Hugo Villafañe, Manish Vinayak, Francesco S Violante, Mukesh Vishwakarma, Sergey Konstantinovitch Vladimirov, Vasily Vlassov, Bay Vo, Simona Ruxandra Volovat, Theo Vos, Isidora S Vujcic, Hatem A Wafa, Yasir Waheed, Elias Bekele Wakwoya, Cong Wang, Denny Wang, Fang Wang, Shu Wang, Yanzhong Wang, Yuan-Pang Wang, Paul Ward, Emebet Gashaw Wassie, Stefanie Watson, Marcia R Weaver, Kosala Gayan Weerakoon, Daniel J Weiss, Katherine M Wells, Yi Feng Wen, Ronny Westerman, Taweewat Wiangkham, Dakshitha Praneeth Wickramasinghe, Nuwan Darshana Wickramasinghe, Peter Willeit, Yohannes Addisu Wondimagegene, Felicia Wu, Juan Xia, Hong Xiao, Gelin Xu, Suowen Xu, Xiaoyue Xu, Ali Yadollahpour, Shirin Yaghoobpoor, Tina Yaghoobpour, Sajad Yaghoubi, Zwanden Sule Yahaya, Danting Yang, Lin Yang, Yuichiro Yano, Habib Yaribeygi, Pengpeng Ye, Renjulal Yesodharan, Subah Abderehim Yesuf, Saber Yezli, Amanuel Yigezu, Paul Yip, Dong Keon Yon, Naohiro Yonemoto, Yuyi You, Mustafa Z Younis, Zabihollah Yousefi, Chuanhua Yu, Yong Yu, Chun-Wei Yuan, Nima Zafari, Fathiah Zakham, Nazar Zaki, Giulia Zamagni, Milad Zandi, Ghazal G Z Zandieh, Moein Zangiabadian, Mikhail Sergeevich Zastrozhin, Haijun Zhang, Meixin Zhang, Yunquan Zhang, Chenwen Zhong, Juexiao Zhou, Bin Zhu, Lei Zhu, Magdalena Zielińska, Zhiyong Zou, Samer H Zyoud, Christopher J L Murray, Amanda E Smith, and Stein Emil Vollset
Abstract: Background: Accurate assessments of current and future fertility-including overall trends and changing population age structures across countries and regions-are essential to help plan for the profound social, economic, environmental, and geopolitical challenges that these changes will bring. Estimates and projections of fertility are necessary to inform policies involving resource and health-care needs, labour supply, education, gender equality, and family planning and support. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 produced up-to-date and comprehensive demographic assessments of key fertility indicators at global, regional, and national levels from 1950 to 2021 and forecast fertility metrics to 2100 based on a reference scenario and key policy-dependent alternative scenarios. Methods: To estimate fertility indicators from 1950 to 2021, mixed-effects regression models and spatiotemporal Gaussian process regression were used to synthesise data from 8709 country-years of vital and sample registrations, 1455 surveys and censuses, and 150 other sources, and to generate age-specific fertility rates (ASFRs) for 5-year age groups from age 10 years to 54 years. ASFRs were summed across age groups to produce estimates of total fertility rate (TFR). Livebirths were calculated by multiplying ASFR and age-specific female population, then summing across ages 10-54 years. To forecast future fertility up to 2100, our Institute for Health Metrics and Evaluation (IHME) forecasting model was based on projections of completed cohort fertility at age 50 years (CCF50; the average number of children born over time to females from a specified birth cohort), which yields more stable and accurate measures of fertility than directly modelling TFR. CCF50 was modelled using an ensemble approach in which three sub-models (with two, three, and four covariates variously consisting of female educational attainment, contraceptive met need, population density in
Published: 2024

8. A Statistical Study of Soft X-Ray Flares on Solar-type Stars

Author: Z. H. Zhao, Z. Q. Hua, X. Cheng, Z. Y. Li, and M. D. Ding
Subjects: X-ray stars, Stellar activity, Stellar flares, Stellar x-ray flares, Flare stars, Magnetic fields, Astrophysics, QB460-466
Abstract: The statistical characteristics of stellar flares at optical bands have received extensive study, but they remain to be studied at soft X-ray bands, in particular for solar-type stars. Here, we present a statistical study of soft X-ray flares on solar-type stars, which can help in understanding the multiwavelength behaviors of stellar flares. We mainly use Chandra Source Catalog Release 2.0, which includes a number of flaring stars with denoted variability, and Gaia Data Release 3, which includes the necessary information for classifying stars. We also develop a set of methods for identifying and classifying stellar soft X-ray flares and estimating their properties. A detailed statistical investigation of 129 flare samples on 103 nearby solar-type stars as selected yields the following main results. (1) The flare energy emitted at the soft X-ray band in our sample ranges from ∼10 ^33 to ∼10 ^37 erg, and the majority of them are superflares, with the most energetic one having energy of ${6.0}_{-4.7}^{+3.2}\times {10}^{37}\ \mathrm{erg}$ . (2) The flare duration is related to its energy as formulated by ${T}_{\mathrm{duration},\mathrm{SXR}}\propto {E}_{\mathrm{flare},\mathrm{SXR}}^{\ 0.201\pm 0.024}$ , which is different from those derived at optical and near-IR bands, indicating distinct radiation mechanisms at different bands. (3) The frequency distribution of stellar flares as a function of energy is formulated as ${{dN}}_{\mathrm{flare}}/{{dE}}_{\mathrm{flare},\mathrm{SXR}}\propto {E}_{\mathrm{flare},\mathrm{SXR}}^{\ -1.77}$ , which is similar to the results found at other bands and on other types of stars, indicating that the energy emitted at the soft X-ray band could be a constant fraction of the full-band bolometric energy.
Published: 2024
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9. Rotation and Confined Eruption of a Double Flux-rope System

Author: X. M. Zhang, J. H. Guo, Y. Guo, M. D. Ding, and Rony Keppens
Subjects: Solar filament eruptions, Solar rotation, Magnetic fields, Solar activity, Solar coronal mass ejections, Magnetohydrodynamics, Astrophysics, QB460-466
Abstract: We perform a data-constrained simulation with the zero- β assumption to study the mechanisms of strong rotation and failed eruption of a filament in active region 11474 on 2012 May 5 observed by Solar Dynamics Observatory and Solar Terrestrial Relations Observatory. The initial magnetic field is provided by nonlinear force-free field extrapolation, which is reconstructed by the regularized Biot–Savart laws and magnetofrictional method. Our simulation reproduces most observational features very well, e.g., the filament large-angle rotation of about 130°, the confined eruption, and the flare ribbons, allowing us to analyze the underlying physical processes behind observations. We discover two flux ropes in the sigmoid system, an upper flux rope (MFR1) and a lower flux rope (MFR2), which correspond to the filament and hot channel in observations, respectively. Both flux ropes undergo confined eruptions. MFR2 grows by tether-cutting reconnection during the eruption. The rotation of MFR1 is related to the shear-field component along the axis. The toroidal field tension force and the nonaxisymmetry forces confine the eruption of MFR1. We also suggest that the mutual interaction between MFR1 and MFR2 contributes to the large-angle rotation and the eruption failure. In addition, we calculate the temporal evolution of the twist and writhe of MFR1, which is a hint of probable reversal rotation.
Published: 2024
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10. Generalized Coronal Loop Scaling Laws and Their Implication for Turbulence in Solar Active Region Loops

Author: Y. Dai, J. J. Xiang, and M. D. Ding
Subjects: Solar active regions, Solar corona, Solar coronal loops, Hydrodynamics, Astrophysics, QB460-466
Abstract: Recent coronal loop modeling has emphasized the importance of combining both Coulomb collisions and turbulent scattering to characterize field-aligned thermal conduction, which invokes a hybrid loop model. In this work, we generalize the hybrid model by incorporating a nonuniform heating and cross section that are both formulated by a power-law function of temperature. Based on the hybrid model solutions, we construct scaling laws that relate loop-top temperature ( T _a ) and heating rate ( H _a ) to other loop parameters. It is found that the loop-top properties for turbulent loops are additionally power-law functions of the turbulent mean free path ( λ _T ), with the functional forms varying from situation to situation, depending on the specification of the heating and/or areal parameters. More importantly, both a sufficiently footpoint-concentrated heating and a cross-sectional expansion with height can effectively weaken (strengthen) the negative (positive) power-law dependence of T _a ( H _a ) on λ _T . The reason lies in a notable reduction of heat flux by footpoint heating and/or cross-sectional expansion in the turbulence-dominated coronal part, where turbulent scattering introduces a much weaker dependence of the conduction coefficient on temperature. In this region, therefore, the reduction of the heat flux predominately relies on a backward flattening of the temperature gradient. Through numerical modeling that incorporates more realistic conditions, this scenario is further consolidated. Our results have important implications for solar active region (AR) loops. With the factors of nonuniform heating and cross section taken into account, AR loops can bear relatively stronger turbulence while still keeping a physically reasonable temperature for nonflaring loops.
Published: 2024
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11. Developing an Automated Detection, Tracking, and Analysis Method for Solar Filaments Observed by CHASE via Machine Learning

Author: Z. Zheng, Q. Hao, Y. Qiu, J. Hong, C. Li, and M. D. Ding
Subjects: Solar filaments, Astronomy image processing, Convolutional neural networks, Astrophysics, QB460-466
Abstract: Studies on the dynamics of solar filaments have significant implications for understanding their formation, evolution, and eruption, which are of great importance for space weather warning and forecasting. The H α Imaging Spectrograph (HIS) on board the recently launched Chinese H α Solar Explorer (CHASE) can provide full-disk solar H α spectroscopic observations, which bring us an opportunity to systematically explore and analyze the plasma dynamics of filaments. The dramatically increased observation data require automated processing and analysis, which are impossible if dealt with manually. In this paper, we utilize the U-Net model to identify filaments and implement the Channel and Spatial Reliability Tracking algorithm for automated filament tracking. In addition, we use the cloud model to invert the line-of-sight velocity of filaments and employ the graph theory algorithm to extract the filament spine, which can advance our understanding of the dynamics of filaments. The favorable test performance confirms the validity of our method, which will be implemented in the following statistical analyses of filament features and dynamics of CHASE/HIS observations.
Published: 2024
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12. Sun-as-a-star Study of an X-class Solar Flare with Spectroscopic Observations of CHASE

Author: Y. L. Ma, Q. H. Lao, X. Cheng, B. T. Wang, Z. H. Zhao, S. H. Rao, C. Li, and M. D. Ding
Subjects: The Sun, Solar flares, Solar flare spectra, Stellar flares, Astrophysics, QB460-466
Abstract: Sun-as-a-star spectroscopic characteristics of solar flares can be used as a benchmark for the detection and analysis of stellar flares. Here, we study the Sun-as-a-star properties of an X1.0 solar flare, using high-resolution spectroscopic data obtained by the Chinese H α Solar Explorer (CHASE). A noise reduction algorithm based on discrete Fourier transformation is first employed to enhance the signal-to-noise ratio of the space-integral H α spectrum, with a focus on its typical characteristics. For the flare of interest, we find that the average H α profile displays a strong emission at the line center and an obvious line broadening. It also presents a clear red asymmetry, corresponding to a redshift velocity of around 50 km s ^−1 that slightly decreases with time, consistent with previous results. Furthermore, we study how the size of the space-integral region affects the characteristics of the flare's Sun-as-a-star H α profile. It is found that although the redshift velocity calculated from the H α profile remains unchanged, the detectability of the characteristics weakens as the space-integral region becomes larger. An upper limit on the size of the target region where the red asymmetry is detectable is estimated. It is also found that the intensity in H α profiles, measured by the equivalent widths of the spectra, are significantly underestimated if the H α spectra are further averaged in the time domain.
Published: 2024
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13. Aerodynamic size-resolved composition and cloud condensation nuclei properties of aerosols in a Beijing suburban region

Author: C. Yu, D. Liu, K. Hu, P. Tian, Y. Wu, D. Zhao, H. Wu, D. Hu, W. Guo, Q. Li, M. Huang, D. Ding, and J. D. Allan
Subjects: Physics, QC1-999, Chemistry, QD1-999
Abstract: The size-resolved physiochemical properties of aerosols determine their atmospheric lifetime, cloud interactions and the deposition rate on the human respiratory system; however most atmospheric composition studies tend to evaluate these properties in bulk. This study investigated size-resolved constituents of aerosols on mass and number basis, and their droplet activation properties, by coupling a suite of online measurements with an aerosol aerodynamic classifier (AAC) based on aerodynamic diameter (Da) in Pinggu, a suburb of Beijing. While organic matter accounted for a large fraction of mass, a higher contribution of particulate nitrate at larger sizes (Da>300 nm) was found under polluted cases. By considering the mixing state of refractory-black-carbon-containing particles (rBCc) and composition-dependent densities, aerosols including rBCc were confirmed to be nearly spherical at Da>300 nm. Importantly, the number fraction of rBCc was found to increase with Da at all pollution levels. The number fraction of refractory black carbon (rBC) is found to increase from ∼3 % at ∼90 nm to ∼15 % at ∼1000 nm, and this increasing rBC number fraction may be caused by the coagulation during atmospheric ageing. The droplet activation diameter at a water supersaturation of 0.2 % was 112±6 and 193±41 nm for all particles with Da smaller than 1 µm (PM1) and rBCc respectively. As high as 52±6 % of rBCc and 50±4 % of all PM1 particles in number could be activated under heavy pollution due to enlarged particle size, which could be predicted by applying the volume mixing of substance hygroscopicity within rBCc. As rBCc contribute to the quantity of aerosols at larger particle size, these thickly coated rBCc may contribute to the radiation absorption significantly or act as an important source of cloud condensation nuclei (CCN). This size regime may also exert important health effects due to their higher deposition rate.
Published: 2022
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14. Surface ozone impacts on major crop production in China from 2010 to 2017

Author: D. Li, D. Shindell, D. Ding, X. Lu, L. Zhang, and Y. Zhang
Subjects: Physics, QC1-999, Chemistry, QD1-999
Abstract: Exposure to elevated surface ozone is damaging to crops. In this study, we performed an analysis of temporal and spatial distributions of relative yield losses (RYLs) attributable to surface ozone for major crops in China from 2010 to 2017, by applying AOT40 metrics (hourly ozone concentration over a threshold of 40 ppbv during the growing season) simulated using a chemical transport model. The major crops in China include wheat, rice (including double early and late rice, and single rice), maize (including north and south maize), and soybean. The aggregated production and associated economic losses in China and major provinces were evaluated by combing annual crop production yields and crop market prices. We estimated that the national annual average AOT40 in China increased from 21.98 ppm h in 2010 to 23.85 ppm h in 2017, with a peak value of 35.69 ppm h in 2014, as simulated with the model. There is significant spatial heterogeneity for the AOT40 and RYLs across the four crops due to the seasonal ozone variations. We calculated that national mean RYLs for wheat, rice, maize, and soybean were 11.45 %–19.74 %, 7.59 %–9.29 %, 0.07 %–3.35 %, and 6.51 %–9.92 %, respectively, from 2010 to 2017. The associated crop yield losses were estimated at 13.81–36.51, 16.89–20.03, 4.59–8.17, and 1.09–1.84 million metric tons (Mt) respectively, which accounted for annual average economic loss of USD 9.55 billion, USD 8.53 billion, USD 2.23 billion, and USD 1.16 billion individually over the 8 years. Our study provides the first long-term quantitative estimation of crop yield losses and their economic cost from surface ozone exposure in China before and after the China Clean Air Act in 2013, and improves understanding of the spatial sensitivity of Chinese crops to ozone impacts.
Published: 2022
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15. Interaction between aerosol and thermodynamic stability within the planetary boundary layer during wintertime over the North China Plain: aircraft observation and WRF-Chem simulation

Author: H. Luo, L. Dong, Y. Chen, Y. Zhao, D. Zhao, M. Huang, D. Ding, J. Liao, T. Ma, M. Hu, and Y. Han
Subjects: Physics, QC1-999, Chemistry, QD1-999
Abstract: Aerosol–planetary boundary layer (PBL) interaction has been proposed as a key mechanism for stabilizing the atmosphere and exacerbating surface air pollution. Although the understanding of this process has progressed enormously, its magnitude and impact remain uncertain and vary widely concerning aerosol types, vertical distributions, synoptic conditions, etc. In this study, our primary interest is to distinguish the aerosol–PBL interaction of absorbing and scattering aerosols under contrasting synoptic patterns and aerosol vertical distributions. Detailed in situ aircraft (King Air 350) measurements and online coupled model Weather Research and Forecasting with Chemistry (WRF-Chem) simulations are explored over the North China Plain (NCP). Furthermore, a long-term PBL stability trend from 1980 to 2020 over the NCP is also investigated. The aircraft measurements and surface observations show that the surface air pollution over the city of Baoding on 3 January is heavier than that on 4 January 2020. In addition, the aerosols are restricted to the low layer on 3 January, whereas the aerosols mix more homogeneously in an upwards direction on 4 January. Thus, we focus on the 2 d with distinct synoptic circumstances, PBL stability, and aerosol vertical distributions over the NCP. According to the WRF-Chem modeling, the synoptic pattern over Baoding differs between the 2 d. The prevailing wind direction is opposite with a southwesterly wind on 3 January and a northeasterly wind on 4 January. The results indicate that the synoptic condition may affect the PBL thermal structure, thus affecting the aerosol vertical distribution. Additionally, the sensitive numerical experiments reveal that the light-absorbing and light-scattering aerosols have different effects on altering the PBL thermal structure. The inhibition effect of scattering aerosols on the PBL appears to be independent of the aerosol height distribution and solely depends on its concentration. However, the aerosol–PBL feedback of absorbing aerosols is highly dependent on its vertical distribution. Besides the 2 d case investigation, the analysis of the modeling results for nearly 1 month from 3 to 30 January 2020 in Baoding yields a more robust and representative conclusion. Our analysis highlights that we should principally concentrate on controlling the emissions of scattering aerosols under the stable stratification, while cooperating to control the emissions of scattering and absorbing aerosols in an unstable stratification. Moreover, the long-term interannual variation in the PBL stability shows a strong correlation with the East Asian winter monsoon, which seems to be valuable in determining which pollutants to target in different monsoon years and attaining more precise air pollution control. Based on the numerical simulations and observational constraints, a concept scheme description has been concluded to deepen our recognition of the interactions between thermodynamic stability and aerosols within the PBL over the NCP region.
Published: 2022
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16. Simulated impacts of vertical distributions of black carbon aerosol on meteorology and PM2.5 concentrations in Beijing during severe haze events

Author: D. Chen, H. Liao, Y. Yang, L. Chen, D. Zhao, and D. Ding
Subjects: Physics, QC1-999, Chemistry, QD1-999
Abstract: Vertical profiles of black carbon (BC) play a critical role in modifying the meteorological conditions such as temperature, planetary boundary layer height (PBLH), and regional circulation, which influence surface layer concentrations of PM2.5 (particulate matter with a diameter of 2.5 µm or less; the surface layer covers from 0 to 79.5 m). However, BC vertical profiles in current models usually have large uncertainties. In this study, by using measurements of BC vertical profiles in Beijing collected by King Air 350 aircraft and the Weather Research and Forecasting with Chemistry model (WRF-Chem) coupled with an improved integrated process (IPR) analysis scheme, we investigated the direct radiative effect (DRE) of BC with different vertical profiles on meteorology and PM2.5 concentrations in Beijing during two severe haze events (11–12 and 16–19 December 2016). Compared with measurements in Beijing, the model overestimated BC concentrations by 87.4 % at the surface and underestimated BC mass by 14.9 % at altitudes of 300–900 m as averaged over the two pollution events. The BC DRE with the default vertical profiles from the model heated the air around 300 m altitude, but the warming would be stronger when BC vertical profiles were modified for each day using the observed data during the two severe haze events. Accordingly, compared to the simulation with the default vertical profiles of BC, PBLH was reduced further by 24.7 m (6.7 %) and 6.4 m (3.8 %) in Beijing in the first and second haze events, respectively, with the modified vertical profiles, and hence the surface layer PM2.5 concentrations were higher by 9.3 µg m−3 (4.1 %) and 5.5 µg m−3 (3.0 %) over central Beijing, owing to increased positive contributions of vertical mixing and chemical processes. Furthermore, we quantified by sensitivity experiments the roles of BC vertical profiles with six exponential decline functions (C(h)=C0×e-h/hs and hs = 0.35, 0.48, 0.53, 0.79, 0.82, and 0.96) parameterized on the basis of the observations. A larger hs means less BC at the surface and more BC in the upper atmosphere, resulting in less solar radiation reaching the ground and consequently a stronger cooling at the surface (+0.21 with hs of 0.35 vs. −0.13∘ with hs of 0.96). Our results indicate that it is very important to have accurate vertical profiles of BC in simulations of meteorology and PM2.5 concentrations during haze events.
Published: 2022
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17. Formation of a Long Filament Through the Connection of Two Filament Segments Observed by CHASE

Author: H. T. Li, X. Cheng, Y. W. Ni, C. Li, S. H. Rao, J. H. Guo, M. D. Ding, and P. F. Chen
Subjects: Solar filaments, Solar magnetic reconnection, Astrophysics, QB460-466
Abstract: We present imaging and spectroscopic diagnostics of a long filament during its formation with the observations from the Chinese H α Solar Explorer and Solar Dynamics Observatory. The seed filament first appeared at about 05:00 UT on 2022 September 13. Afterward, it grew gradually and connected to another filament segment nearby, building up a long filament at about 20:00 UT on the same day. The CHASE H α spectra show an obvious centroid absorption with mild broadening at the main spine of the long filament, which is interpreted as evidence of filament material accumulation. More interestingly, near the footpoints of the filament, persistent redshifts have been detected in the H α spectra during the filament formation, indicating continuous drainage of filament materials. Furthermore, through inspecting the extreme-ultraviolet (EUV) images and magnetograms, it was found that EUV jets and brightenings appeared repeatedly at the junction of the two filament segments, where opposite magnetic polarities converged and canceled each other continuously. These results suggest the occurrence of intermittent magnetic reconnection that not only connects magnetic structures of the two filament segments but also supplies cold materials for the filament channel likely by the condensation of injected hot plasma, even though a part of the cold materials falls down to the filament footpoints at the same time.
Published: 2023
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18. Spectral Observations and Modeling of a Solar White-light Flare Observed by CHASE

Author: De-Chao Song, Jun Tian, Y. Li, M. D. Ding, Yang Su, Sijie Yu, Jie Hong, Ye Qiu, Shihao Rao, Xiaofeng Liu, Qiao Li, Xingyao Chen, Chuan Li, and Cheng Fang
Subjects: Solar activity, Solar flares, Solar flare spectra, Solar photosphere, Solar chromosphere, Solar x-ray emission, Astrophysics, QB460-466
Abstract: The heating mechanisms of solar white-light flares remain unclear. We present an X1.0 white-light flare on 2022 October 2 (SOL2022-10-02T20:25) observed by the Chinese H α Solar Explorer that provides two-dimensional spectra in the visible light for the full solar disk with a seeing-free condition. The flare shows a prominent enhancement of ∼40% in the photospheric Fe i line at 6569.2 Å, and the nearby continuum also exhibits a maximum enhancement of ∼40%. For the continuum near the Fe i line at 6173 Å from the Helioseismic and Magnetic Imager on board the Solar Dynamics Observatory, it is enhanced up to ∼20%. At the white-light kernels, the Fe i line at 6569.2 Å has a symmetric Gaussian profile that is still in absorption and the H α line at 6562.8 Å displays a very broad emission profile with a central reversal plus a red or blue asymmetry. The white-light kernels are cospatial with the microwave footpoint sources observed by the Expanded Owens Valley Solar Array and the time profile of the white-light emission matches that of the hard X-ray emission above 30 keV from the Gamma-ray Burst Monitor (GBM) on Fermi. These facts indicate that the white-light emission is qualitatively related to a nonthermal electron beam. We also perform a radiative hydrodynamic simulation with the electron-beam parameters constrained by the hard X-ray observations from Fermi/GBM. The result reveals that the white-light enhancement cannot be well explained by a pure electron-beam heating together with its induced radiative backwarming but may need additional heating sources such as Alfvén waves.
Published: 2023
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19. Improving the representation of HONO chemistry in CMAQ and examining its impact on haze over China

Author: S. Zhang, G. Sarwar, J. Xing, B. Chu, C. Xue, A. Sarav, D. Ding, H. Zheng, Y. Mu, F. Duan, T. Ma, and H. He
Subjects: Physics, QC1-999, Chemistry, QD1-999
Abstract: We compare Community Multiscale Air Quality (CMAQ) model predictions with measured nitrous acid (HONO) concentrations in Beijing, China, for December 2015. The model with the existing HONO chemistry in CMAQ severely underestimates the observed HONO concentrations with a normalized mean bias of −97 %. We revise the HONO chemistry in the model by implementing six additional heterogeneous reactions in the model: the reaction of nitrogen dioxide (NO2) on ground surfaces, the reaction of NO2 on aerosol surfaces, the reaction of NO2 on soot surfaces, the photolysis of aerosol nitrate, the nitric acid displacement reaction, and the hydrochloric acid displacement reaction. The model with the revised chemistry substantially increases HONO predictions and improves the comparison with observed data with a normalized mean bias of −5 %. The photolysis of HONO enhances daytime hydroxyl radical by almost a factor of 2. The enhanced hydroxyl radical concentrations compare favorably with observed data and produce additional sulfate via the reaction with sulfur dioxide, aerosol nitrate via the reaction with nitrogen dioxide, and secondary organic aerosols via the reactions with volatile organic compounds. The additional sulfate stemming from revised HONO chemistry improves the comparison with observed concentration; however, it does not close the gap between model prediction and the observation during polluted days.
Published: 2021
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20. Reduced volatility of aerosols from surface emissions to the top of the planetary boundary layer

Author: Q. Liu, D. Liu, Y. Wu, K. Bi, W. Gao, P. Tian, D. Zhao, S. Li, C. Yu, G. Tang, K. Hu, S. Ding, Q. Gao, F. Wang, S. Kong, H. He, M. Huang, and D. Ding
Subjects: Physics, QC1-999, Chemistry, QD1-999
Abstract: Aerosols from surface emission can be transported upwards through convective mixing in the planetary boundary layer (PBL), which subsequently interact with clouds, serving as important sources to nucleate droplets or ice particles. However, the evolution of aerosol composition during this vertical transport has yet to be explicitly understood. In this study, simultaneous measurements of detailed aerosol compositions were conducted at two sites, namely urban Beijing (50 m above sea level – a.s.l.) and Haituo mountain (1344 m a.s.l.) during wintertime, representing the anthropogenically polluted surface environment and the top of the PBL, respectively. The pollutants from surface emissions were observed to reach the mountain site on daily basis through daytime PBL convective mixing. From the surface to the top of PBL, we found efficient transport or formation of lower-volatility species (black carbon, sulfate, and low-volatile organic aerosol, OA); however, a notable reduction in semivolatile substances, such as the fractions of nitrate and semivolatile OA reduced by 74 % and 76 %, respectively, during the upward transport. This implies that the mass loss of these semivolatile species was driven by the evaporation process, which repartitioned the condensed semivolatile substances to the gas phase when aerosols were transported and exposed to a cleaner environment. In combination with the oxidation processes, these led to an enhanced oxidation state of OA at the top of the PBL compared to surface environment, with an increase of oxygen to carbon atomic ratio by 0.2. Such a reduction in aerosol volatility during vertical transport may be important in modifying its viscosity, nucleation activity, and atmospheric lifetime.
Published: 2021
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21. The role of non-axisymmetry of magnetic flux rope in constraining solar eruptions

Author: Ze Zhong, Yang Guo, and M. D. Ding
Subjects: Science
Abstract: The competition between different components of the Lorentz force defines whether a solar eruption fails or not. Here, the authors show a new Lorentz force component, which plays a major role in preventing magnetic flux ropes from erupting successfully.
Published: 2021
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22. Optical and hygroscopic properties of black carbon influenced by particle microphysics at the top of the anthropogenically polluted boundary layer

Author: S. Ding, D. Liu, K. Hu, D. Zhao, P. Tian, F. Wang, R. Li, Y. Chen, H. He, M. Huang, and D. Ding
Subjects: Physics, QC1-999, Chemistry, QD1-999
Abstract: Aerosols at the top of the planetary boundary layer (PBL) could modify its atmospheric dynamics by redistributing the solar radiation and start to be activated to form low-level cloud at this layer. Black carbon (BC), as an aerosol component efficiently absorbing solar radiation, can introduce heating and positive radiative effects at this sensitive layer, especially in the polluted PBL over the continent. This study presents continuous measurements of detailed BC properties at a mountain site located at the top of the polluted PBL over the North China Plain, during seasons (3 and 4 weeks of data during winter and summer, respectively) with contrasting emission structure and meteorology. The pollution level was persistently influenced by local surface anthropogenic emission on a daily basis through daytime convective mixing, but the concentration was also enhanced or diluted depending on air mass direction, defined as a neutral, polluted and diluted PBL, respectively. Winter was observed to have a higher BC mass fraction (4 %–8 %) than summer (2 %–7 %). By resolving the detailed particle size-resolved mixing state of BC in optical and hygroscopic models, we found an enhanced BC mass absorption cross section (MACBC) for the polluted PBL (up to 13 m2 g−1 at λ = 550 nm), which was 5 % higher during summer than winter due to a smaller BC core size. The higher BC mass fraction in winter corresponded to a lower single-scattering albedo by 0.03–0.09 than summer, especially the lowest for the diluted winter PBL (0.86 ± 0.02). The water supersaturation (SS) required to activate half the number of BC decreased from 0.21 % ± 0.08 % to 0.1 % ± 0.03 % for the winter diluted and polluted PBL and from 0.22 % ± 0.06 % to 0.17 % ± 0.05 % for summer. Notably, at the top of the anthropogenically polluted PBL in both seasons, the enlarged BC with enhanced absorption capacity could also be efficiently droplet activated; e.g. winter (summer) BC with an MAC of 9.84 ± 1.2 (10.7 ± 1) m2 g−1 could be half activated at SS = 0.13 % ± 0.06 % (0.18 % ± 0.05 %). This BC at the top of the PBL can more directly interact with the free troposphere and be transported to a wider region, exerting important direct and indirect radiative impacts.
Published: 2021
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23. Data-constrained Magnetohydrodynamic Simulation of an Intermediate Solar Filament Eruption

Author: Yang Guo, Jinhan Guo, Yiwei Ni, M. D. Ding, P. F. Chen, Chun Xia, Rony Keppens, and Kai E. Yang
Subjects: Solar prominences, Solar magnetic fields, Magnetohydrodynamics, Solar corona, Astrophysics, QB460-466
Abstract: Solar eruptive activities could occur in weak magnetic field environments and over large spatial scales, which are especially relevant to eruptions involving intermediate or quiescent solar filaments. To handle the large scales, we implement and apply a flux rope embedding method using regularized Biot–Savart laws in the spherical coordinate system. Combined with a potential field source surface model and a magneto-frictional method, a nonlinear force-free field comprising a flux rope embedded in a potential field is constructed. Using the combined nonlinear force-free field as the initial condition, we then perform a zero- β data-constrained magnetohydrodynamic (MHD) simulation for an M8.7 flare at 03:38 UT on 2012 January 23. The MHD model reproduces the eruption process, flare ribbon evolution (represented by the quasi-separatrix layer evolution), and kinematics of the flux rope. This approach could potentially model global-scale eruptions from weak field regions.
Published: 2023
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24. Sequential Remote Brightenings and Co-spatial Fast Downflows during Two Successive Flares

Author: B. T. Wang, X. Cheng, C. Li, J. Chen, and M. D. Ding
Subjects: Solar flares, Active solar corona, Solar magnetic reconnection, Solar magnetic fields, Astrophysics, QB460-466
Abstract: Remote brightenings often appear at the outskirts of the active regions of solar eruptive events. Nevertheless, their origin remains to be ascertained. In this study, we report imaging and spectroscopic observations of sequential remote brightenings with a combination of observations from the H α Imaging Spectrograph on board the Chinese H α Solar Explorer, which is the first space-based solar telescope of China, and from the Solar Dynamics Observatory. It is found that during two successive M-class flares occurring on 2022 August 17 multiple ribbon-like brightenings appeared in sequence away from the flaring active region. Meanwhile, abundant cool filament materials moved downward to the sequential remote brightenings, which were visible at the H α red wing with a line-of-sight speed of up to 70 km s ^−1 . The extrapolated three-dimensional magnetic field configuration shows that the sequential remote brightenings correspond to the footpoints of closed ambient field lines whose conjugate footpoints are rooted in the main flare site. We suggest that the sequential remote brightenings are most likely to be caused by the heating of the interchange reconnection between the erupting flux rope and the closed ambient field, during which the rope-hosting filament materials are transferred to the periphery of the flaring active region along the closed ambient field rather than to the interplanetary space, such as in the scenario of slow solar wind formation.
Published: 2023
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25. Modeling the impact of heterogeneous reactions of chlorine on summertime nitrate formation in Beijing, China

Author: X. Qiu, Q. Ying, S. Wang, L. Duan, J. Zhao, J. Xing, D. Ding, Y. Sun, B. Liu, A. Shi, X. Yan, Q. Xu, and J. Hao
Subjects: Physics, QC1-999, Chemistry, QD1-999
Abstract: Comprehensive chlorine heterogeneous chemistry is incorporated into the Community Multiscale Air Quality (CMAQ) model to evaluate the impact of chlorine-related heterogeneous reaction on diurnal and nocturnal nitrate formation and quantify the nitrate formation from gas-to-particle partitioning of HNO3 and from different heterogeneous pathways. The results show that these heterogeneous reactions increase the atmospheric Cl2 and ClNO2 level (∼ 100 %), which further affects the nitrate formation. Sensitivity analyses of uptake coefficients show that the empirical uptake coefficient for the O3 heterogeneous reaction with chlorinated particles may lead to the large uncertainties in the predicted Cl2 and nitrate concentrations. The N2O5 uptake coefficient with particulate Cl− concentration dependence performs better in capturing the concentration of ClNO2 and nocturnal nitrate concentration. The reaction of OH and NO2 in the daytime increases the nitrate by ∼15 % when the heterogeneous chlorine chemistry is incorporated, resulting in more nitrate formation from HNO3 gas-to-particle partitioning. By contrast, the contribution of the heterogeneous reaction of N2O5 to nitrate concentrations decreases by about 27 % in the nighttime, when its reactions with chlorinated particles are considered. However, the generated gas-phase ClNO2 from the heterogeneous reaction of N2O5 and chlorine-containing particles further reacts with the particle surface to increase the nitrate by 6 %. In general, this study highlights the potential of significant underestimation of daytime concentrations and overestimation of nighttime nitrate concentrations for chemical transport models without proper chlorine chemistry in the gas and particle phases.
Published: 2019
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26. Outcomes of gynecologic cancer surgery during the COVID-19 pandemic: an international, multicenter, prospective CovidSurg-Gynecologic Oncology Cancer study

Author: Nepogodiev, Dmitri, Siaw-Acheampong, Kwabena, Benson, Ruth A., Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E., Evans, Jonathan P., Glasbey, James C., Gujjuri, Rohan R., Heritage, Emily, Jones, Conor S., Kamarajah, Sivesh K., Khatri, Chetan, Khaw, Rachel A., Keatley, James M., Knight, Andrew, Lawday, Samuel, Li, Elizabeth, Mann, Harvinder S., Marson, Ella J., McLean, Kenneth A., Mckay, Siobhan C., Mills, Emily C., Pellino, Gianluca, Picciochi, Maria, Taylor, Elliott H., Tiwari, Abhinav, Simoes, Joana FF., Trout, Isobel M., Venn, Mary L., Wilkin, Richard JW., Bhangu, Aneel, Abbott, Tom EF., Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O., Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Arnaud, Alexis P., Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K., Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A., Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J., Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F., Davidson, Giana H., Desai, Anant, Di Saverio, Salomone, Drake, Thomas M., Edwards, John G., Elhadi, Muhammed, Emile, Sameh, Farik, Shebani, Fiore, Marco, Fitzgerald, J Edward, Ford, Samuel, Garmanova, Tatiana, Gallo, Gaetano, Ghosh, Dhruva, Ataíde Gomes, Gustavo Mendonça, Grecinos, Gustavo, Griffiths, Ewen A., Gruendl, Magdalena, Halkias, Constantine, Harrison, Ewen M., Hisham, Intisar, Hutchinson, Peter J., Hwang, Shelley, Isik, Arda, Jenkinson, Michael D., Jonker, Pascal, MA Kaafarani, Haytham, Keller, Debby, Kolias, Angelos, Kruijff, Schelto, Lawani, Ismail, Lederhuber, Hans, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W., Lorena, Maria Aguilera, Modolo, Maria Marta, Major, Piotr, Martin, Janet, Mashbari, Hassan N., Mazingi, Dennis, Metallidis, Symeon, Mohan, Helen M., Moore, Rachel, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S., Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Ntirenganya, Faustin, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Pata, Francesco, Perez Rivera, Carlos Jose, Pinkney, Thomas D., van der Plas, Willemijn, Pockney, Peter, Qureshi, Ahmad, Radenkovic, Dejan, Ramos-De la Medina, Antonio, Richards, Toby, Roberts, Keith, Roslani, April C., Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Satoi, Sohei, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A., Seyi-Olajide, Justina O., Sharma, Neil, Shaw, Catherine A., Shaw, Richard, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D., Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Townend, Philip, Tsoulfas, Georgios, van Ramshorst, Gabrielle H., Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J., Wedderburn, Duane, Wright, Naomi, Booth, Lesley, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Runigamugabo, Emmy, Weir, Carrie Tierney, Dajti I, Albania, C, Allemand, LA, Boccalatte, M, Figari, M, Lamm, J, Larrañaga, C, Marchitelli, F, Noll, D, Odetto, M, Perrotta, J, Saadi, L, Zamora, Ballester, A.M., KE, Tapper, N, Zeff, JI, Valenzuela, C, Alurralde, J, Anastasio, Perez de Nucci A, Apas, EL, Caram, D, Eskinazi, JP, Mendoza, M, Usandivaras, R, Badra, A, Esteban, JS, García, PM, García, JI, Gerchunoff, Lucchini, S.M., NIgra, M.A., L, Vargas, T, Hovhannisyan, A, Stepanyan, CE, Vasey, EGR, Watson, C, Ip, J, Kealey, CSH, Lim, S, Sengupta, S, Ward, E, Wong, T, Gould, R, Gourlay, B, Griffiths, S, Gananadha, M, McLaren, J, Cecire, N, Joshi, S, Salindera, A, Sutherland, JH, Ahn, G, Charlton, S, Chen, N, Gauri, R, Hayhurst, S, Jang, F, Jia, C, Mulligan, W, Yang, G, Ye, H, Zhang, M, Ballal, D, Gibson, D, Hayne, H, McMillan, J, Moss, MJ, Pugliese, T, Richards, YTN, Seow, A, Thian, P, Viswambaram, UG, Vo, J, Bennetts, T, Bright, Brooke-Smith, M., R, Fong, B, 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Ladd, C, Long, H, Malapati, A, Margalit, S, Rapaport, J, Rose, K, Stevens, L, Tsai, D, Vervoort, P, Yesantharao, A, Dehal, D, Klaristenfeld, K, Huynh, H, Kaafarani, L, Naar, M, Qadan, L, Brown, I, Ganly, JE, Mullinax, N, Alpert, C, Gillezeau, Miles DDS MD, F.A.C.S.B.A., E, Taioli, DE, Cha, E, Gleeson, C, Horn, U, Sarpel, N, Gusani, J, Hazelton, J, Maines, JS, Oh, A, Ssentongo, P, Ssentongo, A, Bhama, K, Colling, M, Najarian, M, Azam, A, Choudhry, W, Marx, Y, Abedin, G, Arzumanov, R, Chokshi, S, Gabrilovich, N, Glass, E, Kalyoussef, Parvin-Nejad, F.P., D, Roden, J, Stein, Suarez-Ligon, A., G, Tsui, K, Zhao, J, Fleming, A, Fuson, J, Gigliotti, A, Ovaitt, Y, Ying, MK, Abel, V, Andaya, K, Bigay, Boeck, M.A., H, Chern, C, Corvera, El-Sayed, I., A, Glencer, P, Ha, Hamilton, B.C.S., C, Heaton, K, Hirose, Jablons, D.M., KS, Kirkwood, LZ, Kornblith, JR, Kratz, RH, Lee, PN, Miller, EK, Nakakura, Nunez-Garcia, B., RJ, O’Donnell, D, Ozgediz, P, Park, B, Robinson, A, Sarin, B, Sheu, MG, Varma, KC, Wai, R, Wustrack, MJ, Xu, M, Zimel, D, CA) Beswick, J, Goddard, J, Manor, J, Song, Springs/Loveland, Denver/Colorado, A, Cioci, W, Pavlis, K, Rakoczy, G, Ruiz, R, Saberi, T, Fullmer, C, Gaskill, N, Gross, K, Kiong, CL, Roland, SN, Zafar, M, Abdallah, A, Abouassi, E, Aigbivbalu, M, Almasri, J, Eid, B, George, G, Kulkarni, H, Marwan, M, Mehdi, Andrés M, San, J, Sundaresan, SG, Aoun, VS, Ban, HH, Batjer, K, Bosler, J, Caruso, B, Sumer, D, Abbott, A, Acher, T, Aiken, J, Barrett, E, Foley, PB, Schwartz, AT, Hawkins, A, Maiga, NM, Ruzgar, M, Sion, S, Ullrich, J, Laufer, S, Scasso, Al-Naggar, H., Al-Shehari, M., A, Almassaudi, M, Alsayadi, R, Alsayadi, M, Nahshal, S, Shream, S, AL-Ameri, M, Aldawbali, Fotopoulou, Christina, Khan, Tabassum, Bracinik, Juraj, Glasbey, James, Abu-Rustum, Nadeem, Chiva, Luis, Fagotti, Anna, Fujiwara, Keiichi, Ghebre, Rahel, Gutelkin, Murat, Konney, Thomas O., Ng, Joseph, Pareja, Rene, Kottayasamy Seenivasagam, Rajkumar, Sehouli, Jalid, Surappa, Shylasree T.S., and Leung, Elaine
Published: 2022
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27. A two-in-one Janus NIR-II AIEgen with balanced absorption and emission for image-guided precision surgery

Author: S. Liu, Y. Li, J. Zhang, H. Zhang, Y. Wang, C. Chuah, Y. Tang, J.W.Y. Lam, R.T.K. Kwok, H. Ou, D. Ding, and B.Z. Tang
Subjects: Aggregation-induced emission, Fluorescence, Image-guided surgery, Absorbance, Brightness, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract: Fluorescence imaging in the near-infrared II (NIR-II, 1000–1700 nm) region opens up new avenues for biological systems due to suppressed scattering and low autofluorescence at longer-wavelength photons. Nonetheless, the development of organic NIR-II fluorophores is still limited mainly due to the shortage of efficient molecular design strategy. Herein, we propose an approach of designing Janus NIR-II fluorophores by introducing electronic donors with distinct properties into one molecule. As a proof-of-concept, fluorescent dye 2 TT-m, oC6B with both twisted and planar electronic donors displayed balanced absorption and emission which were absent in its parent compound. The key design strategy for Janus molecule is that it combines the merits of intense absorption from planar architecture and high fluorescence quantum yield from twisted motif. The resulting 2 TT-m, oC6B nanoparticles exhibit a high molar absorptivity of 1.12 ⨯104 M−1 cm−1 at 808 nm and a NIR-II quantum yield of 3.7%, displaying a typical aggregation-induced emission (AIE) attribute. The highly bright and stable 2 TT-m, oC6B nanoparticles assured NIR-II image-guided cancer surgery to resect submillimeter tumor nodules. The present study may inspire further development of molecular design philosophy for highly bright NIR-II fluorophores for biomedical applications.
Published: 2021
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28. Quantification of the enhanced effectiveness of NOx control from simultaneous reductions of VOC and NH3 for reducing air pollution in the Beijing–Tianjin–Hebei region, China

Author: J. Xing, D. Ding, S. Wang, B. Zhao, C. Jang, W. Wu, F. Zhang, Y. Zhu, and J. Hao
Subjects: Physics, QC1-999, Chemistry, QD1-999
Abstract: As one common precursor for both PM2.5 and O3 pollution, NOx gains great attention because its controls can be beneficial for reducing both PM2.5 and O3. However, the effectiveness of NOx controls for reducing PM2.5 and O3 are largely influenced by the ambient levels of NH3 and VOC, exhibiting strong nonlinearities characterized as NH3-limited/NH3-poor and NOx-/VOC-limited conditions, respectively. Quantification of such nonlinearities is a prerequisite for making suitable policy decisions but limitations of existing methods were recognized. In this study, a new method was developed by fitting multiple simulations of a chemical transport model (i.e., Community Multiscale Air Quality Modeling System, CMAQ) with a set of polynomial functions (denoted as pf-RSM) to quantify responses of ambient PM2.5 and O3 concentrations to changes in precursor emissions. The accuracy of the pf-RSM is carefully examined to meet the criteria of a mean normalized error within 2 % and a maximal normalized error within 10 % by using 40 training samples with marginal processing. An advantage of the pf-RSM method is that the nonlinearity in PM2.5 and O3 responses to precursor emission changes can be characterized by quantitative indicators, including (1) a peak ratio (denoted as PR) representing VOC-limited or NOx-limited conditions, (2) a suggested ratio of VOC reduction to NOx reduction to avoid increasing O3 under VOC-limited conditions, (3) a flex ratio (denoted as FR) representing NH3-poor or NH3-rich conditions, and (4) enhanced benefits in PM2.5 reductions from simultaneous reduction of NH3 with the same reduction rate of NOx. A case study in the Beijing–Tianjin–Hebei region suggested that most urban areas present strong VOC-limited conditions with a PR from 0.4 to 0.8 in July, implying that the NOx emission reduction rate needs to be greater than 20–60 % to pass the transition from VOC-limited to NOx-limited conditions. A simultaneous VOC control (the ratio of VOC reduction to NOx reduction is about 0.5–1.2) can avoid increasing O3 during the transition. For PM2.5, most urban areas present strong NH3-rich conditions with a PR from 0.75 to 0.95, implying that NH3 is sufficiently abundant to neutralize extra nitric acid produced by an additional 5–35 % of NOx emissions. Enhanced benefits in PM2.5 reductions from simultaneous reduction of NH3 were estimated to be 0.04–0.15 µg m−3 PM2.5 per 1 % reduction of NH3 along with NOx, with greater benefits in July when the NH3-rich conditions are not as strong as in January. Thus, the newly developed pf-RSM model has successfully quantified the enhanced effectiveness of NOx control, and simultaneous reduction of VOC and NH3 with NOx can assure the control effectiveness of PM2.5 and O3.
Published: 2018
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29. Observationally quantified reconnection providing a viable mechanism for active region coronal heating

Author: Kai E. Yang, Dana W. Longcope, M. D. Ding, and Yang Guo
Subjects: Science
Abstract: The solar corona heating mechanism is still subject to debate. Here, the authors report that impulsive reconnection can give rise to an active region corona that is compatible with extreme-ultraviolet observations.
Published: 2018
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30. A circular white-light flare with impulsive and gradual white-light kernels

Author: Q. Hao, K. Yang, X. Cheng, Y. Guo, C. Fang, M. D. Ding, P. F. Chen, and Z. Li
Subjects: Science
Abstract: White-light flares are rare solar events entailing emission in the optical continuum. Here, the authors report a nearly circular white-light flare observed on March 10th 2015 that contains simultaneously both impulsive and gradual white-light kernels.
Published: 2017
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31. Author Correction: Ultra-high-resolution observations of persistent null-point reconnection in the solar corona

Author: X. Cheng, E. R. Priest, H. T. Li, J. Chen, G. Aulanier, L. P. Chitta, Y. L. Wang, H. Peter, X. S. Zhu, C. Xing, M. D. Ding, S. K. Solanki, D. Berghmans, L. Teriaca, R. Aznar Cuadrado, A. N. Zhukov, Y. Guo, D. Long, L. Harra, P. J. Smith, L. Rodriguez, C. Verbeeck, K. Barczynski, and S. Parenti
Subjects: Multidisciplinary, General Physics and Astronomy, General Chemistry, General Biochemistry, Genetics and Molecular Biology
Published: 2023
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32. The effect of smoking status on inguinal hernia repair outcomes: An ACHQC analysis

Author: Celeste G. Yergin, Delaney D. Ding, Sharon Phillips, Thomas E. Read, and Mazen R. Al-Mansour
Subjects: Surgery
Published: 2023
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33. Formability and magnetic properties of Dy-Co binary amorphous alloys

Author: L. Y. Ma, B. Z. Tang, K. C. Chan, L. Zhao, M. B. Tang, D. Ding, and L. Xia
Subjects: Physics, QC1-999
Abstract: In this study, binary Dy-Co ribbons were synthesized by a conventional melt-spinning approach and glassy ribbons were successfully obtained within the compositional range Dy50Co50 to Dy68Co32. The glass formability and magnetic properties of these amorphous alloys were examined. The compositional dependence of glass formability, Curie temperature and magneto-caloric response of the DyxCo100-x (x=50, 55, 60, 65 and 68) amorphous alloys, as well as the mechanism involved, were determined.
Published: 2018
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34. Cirrhosis regression is associated with improved clinical outcomes in patients with nonalcoholic steatohepatitis

Author: Eric Lawitz, Manuel Romero-Gómez, Quentin M. Anstee, Stephen A. Harrison, Catherine Jia, Zobair M. Younossi, Chuhan Chung, Zachary Goodman, Robert P. Myers, Ryan S Huss, Michael Trauner, Vincent Wai-Sun Wong, Andrew J. Muir, Takeshi Okanoue, Jaime Bosch, D. Ding, Nezam H. Afdhal, Manal F. Abdelmalek, Ling Han, Arun J. Sanyal, Gilead Sciences, and Foster City
Subjects: Liver Cirrhosis, medicine.medical_specialty, Cirrhosis, Hepatology, business.industry, Proportional hazards model, Surrogate endpoint, 610 Medicine & health, medicine.disease, Lower risk, Fibrosis, Gastroenterology, Liver, Non-alcoholic Fatty Liver Disease, Internal medicine, Nonalcoholic fatty liver disease, medicine, Humans, Collagen, Stage (cooking), 610 Medizin und Gesundheit, Transient elastography, business
Abstract: [Background and Aims] Surrogate endpoints that predict complications are necessary for assessment and approval of NASH therapies. We assessed associations between histologic and noninvasive tests (NITs) of fibrosis with liver‐related complications in patients with NASH cirrhosis., [Approach and Results] Patients with compensated cirrhosis due to NASH were enrolled in two placebo‐controlled trials of simtuzumab and selonsertib. Liver fibrosis at baseline and week 48 (W48) was staged by NASH Clinical Research Network (CRN) and Ishak classifications and a machine learning (ML) approach, hepatic collagen and alpha‐smooth muscle actin (α‐SMA) expression were quantified by morphometry, liver stiffness (LS) was measured by transient elastography, and serum NITs (enhanced liver fibrosis [ELF], NAFLD fibrosis score [NFS], and Fibrosis‐4 index [FIB‐4]) were calculated. Cox regression determined associations between these parameters at baseline and their changes over time with adjudicated liver‐related clinical events. Among 1,135 patients, 709 (62%) had Ishak stage 6 fibrosis, and median ELF and LS were 10.66 and 21.1 kPa, respectively. During a median follow‐up of 16.6 months, 71 (6.3%) had a liver‐related event; associated baseline factors included Ishak stage 6 fibrosis, and higher hepatic collagen, α‐SMA expression, ML‐based fibrosis parameters, LS, ELF, NFS, and FIB‐4. Cirrhosis regression observed in 16% (176/1,135) between BL and W48 was associated with a lower risk of events versus nonregression (1.1% [2/176] vs. 7.2% [69/957]; HR, 0.16; 95% CI, 0.04, 0.65 [p = 0.0104]). Conversely, after adjustment for baseline values, increases in hepatic collagen, α‐SMA, ML‐based fibrosis parameters, NFS, and LS were associated with an increased risk of events., [Conclusions] In patients with compensated cirrhosis due to NASH, regression of fibrosis is associated with a reduction in liver‐related complications. These data support the utility of histologic fibrosis regression and NITs as clinical trial endpoints for NASH cirrhosis., This analysis was supported by Gilead Sciences, Inc., Foster City, CA, USA.
Published: 2022
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35. Achieving higher magnetic entropy change peak at lower temperature by minor Ti substitution for Zr in the Fe88Zr8B4 metallic glass

Author: X. N. Zheng, Q. Wang, C. Y. Yue, A. L. Li, D. Ding, and L. Xia
Subjects: Statistical and Nonlinear Physics, Condensed Matter Physics
Abstract: Fe-Zr-B-based amorphous alloys (AAs) show good magnetocaloric effect (MCE) around the ambient temperature, and their maximum magnetic entropy change ([Formula: see text] generally increases with their Curie temperature ([Formula: see text], which means the poor magnetocaloric properties near the cold end of the air conditioner. In this work, by adding 2% (at.%) Ti to replace the Zr element in a [Formula: see text] AA, we successfully fabricated the [Formula: see text] amorphous ribbon. The [Formula: see text] amorphous ribbon exhibits a slightly enhanced glass formability, improved [Formula: see text] and decreased [Formula: see text] when compared to the [Formula: see text] AA. The results are helpful for developing better MCE of the Fe-Zr-B-based metallic glasses working near the cold end of a domestic magnetic air conditioner.
Published: 2023
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36. Unveiling the mechanism for the rapid acceleration phase in a solar eruption

Author: Ze Zhong, Yang Guo, Thomas Wiegelmann, M. D. Ding, and Yao Chen
Subjects: Plasma Physics (physics.plasm-ph), Astrophysics - Solar and Stellar Astrophysics, Physics - Space Physics, Space and Planetary Science, FOS: Physical sciences, Astronomy and Astrophysics, Solar and Stellar Astrophysics (astro-ph.SR), Space Physics (physics.space-ph), Physics - Plasma Physics
Abstract: Two major mechanisms have been proposed to drive the solar eruptions: the ideal magnetohydrodynamic instability and the resistive magnetic reconnection. Due to the close coupling and synchronicity of the two mechanisms, it is difficult to identify their respective contribution to solar eruptions, especially to the critical rapid acceleration phase. Here, to shed light on this problem, we conduct a data-driven numerical simulation for the flux rope eruption on 2011 August 4, and quantify the contributions of the upward exhaust of the magnetic reconnection along the flaring current sheet and the work done by the large-scale Lorentz force acting on the flux rope. Major simulation results of the eruption, such as the macroscopic morphology, early kinematics of the flux rope and flare ribbons, match well with the observations. We estimate the energy converted from the magnetic slingshot above the current sheet and the large-scale Lorentz force exerting on the flux rope during the rapid acceleration phase, and find that (1) the work done by the large-scale Lorentz force is about 4.6 times higher than the former, and (2) decreased strapping force generated by the overlying field facilitates the eruption. These results indicate that the large-scale Lorentz force plays a dominant role in the rapid acceleration phase for this eruption., 12 pages, 5 figures; Accepted for publication in ApJL
Published: 2023

37. Highly Energetic Electrons Accelerated in Strong Solar Flares as a Preferred Driver of Sunquakes

Author: H. Wu, Y. Dai, and M. D. Ding
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), Astrophysics - Solar and Stellar Astrophysics, Physics - Space Physics, Space and Planetary Science, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Solar and Stellar Astrophysics (astro-ph.SR), Space Physics (physics.space-ph)
Abstract: Sunquakes are enhanced seismic waves excited in some energetic solar flares. Up to now, their origin has still been controversial. In this Letter, we select and study 20 strong flares in Solar Cycle 24, whose impulse phase is fully captured by the \emph{Reuven Ramaty High Energy Solar Spectroscopic Imager} (\emph{RHESSI}). For 11 out of 12 sunquake-active flares in our sample, the hard X-ray (HXR) emission shows a good temporal and spatial correlation with the white-light (WL) enhancement and the sunquake. Spectral analysis also reveals a harder photon spectrum that extends to several hundred keV, implying a considerable population of flare-accelerated nonthermal electrons at high energies. Quantitatively, the total energy of electrons above 300 keV in sunquake-active flares is systematically different from that in sunquake-quiet flares, while the difference is marginal for electrons above 50 keV. All these facts support highly energetic electrons as a preferred driver of the sunquakes. Such an electron-driven scenario can be reasonably accommodated in the framework of a recently proposed selection rule for sunquake generation. For the remaining one event, the sunquake epicenter is cospatial with a magnetic imprint, i.e., a permanent change of magnetic field on the photosphere. Quantitative calculation shows that the flare-induced downward Lorentz force can do enough work to power the sunquake, acting as a viable sunquake driver for this specific event., 11 pages, including 1 table and 4 figures. Accepted for publication in ApJL
Published: 2023

38. Evidence of external reconnection between an erupting mini-filament and ambient loops observed by Solar Orbiter/EUI

Author: Z. F. Li, X. Cheng, M. D. Ding, L. P. Chitta, H. Peter, D. Berghmans, P. J. Smith, F. Auchère, S. Parenti, K. Barczynski, L. Harra, U. Schühle, É. Buchlin, C. Verbeeck, R. Aznar Cuadrado, A. N. Zhukov, D. M. Long, L. Teriaca, and L. Rodriguez
Subjects: Sun: flares, Astrophysics - Solar and Stellar Astrophysics, Sun: corona, Space and Planetary Science, FOS: Physical sciences, Astronomy and Astrophysics, flares, Sun: magnetic fields, Sun: corona [Sun], Solar and Stellar Astrophysics (astro-ph.SR)
Abstract: Mini-filament eruptions are one of the most common small-scale transients in the solar atmosphere. However, their eruption mechanisms are still not understood thoroughly. Here, with a combination of 174 A images of high spatio-temporal resolution taken by the Extreme Ultraviolet Imager on board Solar Orbiter and images of the Atmospheric Imaging Assembly on board Solar Dynamics Observatory, we investigate in detail an erupting mini-filament over a weak magnetic field region on 2022 March 4. Two bright ribbons clearly appeared underneath the erupting mini-filament as it quickly ascended, and subsequently, some dark materials blew out when the erupting mini-filament interacted with the outer ambient loops, thus forming a blowout jet characterized by a widening spire. At the same time, multiple small bright blobs of 1-2 Mm appeared at the interaction region and propagated along the post-eruption loops toward the footpoints of the erupting fluxes at a speed of ∼100 km s-1. They also caused a semi-circular brightening structure. Based on these features, we suggest that the mini-filament eruption first experiences internal and then external reconnection, the latter of which mainly transfers mass and magnetic flux of the erupting mini-filament to the ambient corona., Astronomy & Astrophysics, 673, ISSN:0004-6361, ISSN:1432-0746
Published: 2023
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39. Ultra-high-resolution Observations of Persistent Null-point Reconnection in the Solar Corona

Author: X. Cheng, E. R. Priest, H. T. Li, J. Chen, G. Aulanier, L. P. Chitta, Y. L. Wang, H. Peter, X. S. Zhu, C. Xing, M. D. Ding, S. K. Solanki, D. Berghmans, L. Teriaca, R. Aznar Cuadrado, A. N. Zhukov, Y. Guo, D. Long, L. Harra, P. J. Smith, L. Rodriguez, C. Verbeeck, K. Barczynski, S. Parenti, and University of St Andrews. Applied Mathematics
Subjects: MCC, Multidisciplinary, General Physics and Astronomy, FOS: Physical sciences, DAS, General Chemistry, NIS, General Biochemistry, Genetics and Molecular Biology, Space Physics (physics.space-ph), Astrophysics - Solar and Stellar Astrophysics, Physics - Space Physics, QB Astronomy, Solar and Stellar Astrophysics (astro-ph.SR), QB
Abstract: Magnetic reconnection is a key mechanism involved in solar eruptions and is also a prime possibility to heat the low corona to millions of degrees. Here, we present ultra-high-resolution extreme ultraviolet observations of persistent null-point reconnection in the corona at a scale of about 390 km over one hour observations of the Extreme-Ultraviolet Imager on board Solar Orbiter spacecraft. The observations show formation of a null-point configuration above a minor positive polarity embedded within a region of dominant negative polarity near a sunspot. The gentle phase of the persistent null-point reconnection is evidenced by sustained point-like high-temperature plasma (about 10 MK) near the null-point and constant outflow blobs not only along the outer spine but also along the fan surface. The blobs appear at a higher frequency than previously observed with an average velocity of about 80 km s-1 and life-times of about 40 s. The null-point reconnection also occurs explosively but only for 4 minutes, its coupling with a mini-filament eruption generates a spiral jet. These results suggest that magnetic reconnection, at previously unresolved scales, proceeds continually in a gentle and/or explosive way to persistently transfer mass and energy to the overlying corona., Nature Communications, 14 (1), ISSN:2041-1723
Published: 2023
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40. Amelioration of oxidative damage in Solanum melongena seedlings by 24-epibrassinolide during chilling stress and recovery

Author: X. X. Wu, H. D. Ding, J. L. Chen, Z. W. Zhu, and D. S. Zha
Subjects: antioxidant system, asa-gsh cycle, brassinosteroids, eggplant, short-term chilling, Biology (General), QH301-705.5, Plant ecology, QK900-989
Abstract: The effects of foliar application of 24-epibrassinolide (EBR) on chlorophyll content, oxidative damage, and antioxidant capacity in eggplant (Solanum melongena L.) seedlings during a short-term chilling stress and subsequent recovery were investigated. The eggplant seedlings pretreated with 0.1 μM EBR were exposed to 5 °C for 12 h in the dark and then recovered under a normal temperature for another 12 h. The results show that EBR alleviated a chilling-induced oxidative stress reflected by a decrease in malondialdehyde and H2O2 content, O2 .- production rate, and an increase in chlorophyll content and activities of superoxide dismutase, guaicol peroxidase, and catalase. The EBR pretreatment also promoted activities of ascorbate peroxidase, glutathione reductase, dehydroascorbate reductase, as well as the accumulation of ascorbic acid (AsA) and glutathione (GSH) involved in the AsA-GSH cycle. Moreover, after the12 h recovery, EBR plus chilling treated leaves showed no significant changes in content of MDA and chlorophyll a, lower reactive oxygen species (ROS) content, and greater activities of AsA-GSH cycle enzymes than in seedlings only chilled. The results suggest that EBR alleviated an oxidative damage caused by the dark chilling stress and accelerated a recovery rate mainly through increasing the ROS scavenging system including the AsA-GSH cycle.
Published: 2015
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41. Humoral and cellular immune responses to recombinant herpes zoster vaccine in patients with chronic lymphocytic leukemia and monoclonal B cell lymphocytosis

Author: Michael J. Johnson, Sameer A. Parikh, Paul J. Hampel, Timothy G. Call, Jose F. Leis, Jennifer Canniff, Wei D Ding, Congrong Miao, Jennifer A Whitaker, Matthew A. Holets, Richard B. Kennedy, Kari G. Rabe, Neil E. Kay, Heather C. Darby, Eli Muchtar, Myron J. Levin, Saad S. Kenderian, D. Scott Schmid, Yucai Wang, Adriana Weinberg, Amber B. Koehler, Susan L. Slager, and Suzanne R. Hayman
Subjects: Adult, Male, Chronic lymphocytic leukemia, Lymphocytosis, Herpes Zoster, Article, Hypogammaglobulinemia, hemic and lymphatic diseases, medicine, Herpes Zoster Vaccine, Humans, B cell, Aged, Aged, 80 and over, B-Lymphocytes, Immunity, Cellular, biology, business.industry, Antibody titer, Hematology, Middle Aged, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Immunity, Humoral, Vaccination, medicine.anatomical_structure, Immunology, biology.protein, Monoclonal B-cell lymphocytosis, Female, Zoster vaccine, Antibody, business, medicine.drug
Abstract: Monoclonal B cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL) are clonal B cell disorders associated with increased risk of infections and impaired vaccination responses. We investigated the immunogenicity of recombinant zoster vaccine (RZV) in these patients. Individuals with MBL/untreated CLL and Bruton tyrosine kinase inhibitor (BTKi)-treated CLL patients were given two doses of RZV separated by two months. Responses assessed at 3-months and 12-months from the first dose of RZV by an anti-glycoprotein E ELISA antibody assay and by dual-color IFN-γ and IL-2 FLUOROSPOT assays were compared to historic controls matched by age and sex. Sixty-two patients (37 MBL/untreated CLL and 25 BTKi-treated CLL) were enrolled with a median age of 68 years at vaccination. An antibody response at 3 months was seen in 45% of participants, which was significantly lower compared to historic controls (63%, P=0.03). The antibody response did not significantly differ between MBL/untreated CLL and BTKi-treated CLL (51% vs 36%, respectively, P=0.23). The CD4+ T cell response to vaccination was significantly lower in study participants compared to controls (54% vs 96%, P
Published: 2021
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42. CAD-BASED PATH PLANNING FOR LINE LASER SCANNING OF CURVED SURFACE

Author: W. Guo, Z. Zhao, Y. Fu, and D. Ding
Subjects: Surface (mathematics), Optics, Materials science, Laser scanning, business.industry, Mechanical Engineering, Automotive Engineering, CAD, Motion planning, Electrical and Electronic Engineering, Line (text file), business, Industrial and Manufacturing Engineering
Abstract: On-machine measurement by a line laser scanner has a great potential in machining large complex components in aerospace and automation applications. This paper proposes a novel approach for path planning of measuring curved surfaces in a 5-axis machine tool, which takes scanning overlap, visual angle, and working distance into consideration. A conformal mapping algorithm is employed to transform a three-dimensional (3D) mesh surface to a 2D parametric plane. The shortest equidistant paths calculated in the 2D plane are transformed into smooth collision-free scanning paths in the 3D surface. The experiments verify that this method can improve the efficiency by 21.4% and the accuracy by 24.9%.
Published: 2021
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43. [A deep-learning model for the assessment of coronary heart disease and related risk factors via the evaluation of retinal fundus photographs]

Author: Y D, Ding, Y, Zhang, L Q, He, M, Fu, X, Zhao, L K, Huang, B, Wang, Y Z, Chen, Z H, Wang, Z Q, Ma, and Y, Zeng
Published: 2022

44. Hybrid-Magnon Quantum Devices: Strategies and Approaches

Author: Y. Li, J.-C. Qian, Z.-H. Jiang, T.-H. Lo, D. Ding, T. Draher, T. Polakovic, W. Pfaff, A. Schleife, J.-M. Zuo, W.-K. Kwok, V. Novosad, and A. Hoffmann
Published: 2022
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45. MIGRATION, STIGMA AND HEALTH

Author: Delaney D. Ding and Julie H. Levison
Published: 2022
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46. Evaluation of different recipes for chromospheric radiative losses in solar flares

Author: J. Tian, J. Hong, Y. Li, and M. D. Ding
Subjects: Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, FOS: Physical sciences, Astronomy and Astrophysics, Solar and Stellar Astrophysics (astro-ph.SR)
Abstract: Context. Radiative losses are an indispensable part in the numerical simulation of flares. Detailed calculations could be computationally expensive, especially in the chromosphere. There have been some approximate recipes for chromospheric radiative losses in flares, yet their feasibility in flare simulations needs further evaluation. Aims. We aim to evaluate the performance of different recipes for chromospheric radiative losses in flare simulations. Methods. We compare the atmospheric structure and line profiles in beam-heated flares calculated with detailed radiative losses and the approximate recipes. Results. Both GF90 and HCD22 recipes provide acceptable total radiative losses compared with detailed one, but there are discrepancies in the different atmospheric layers during the different evolutionary phases, which leads to misestimations of temperature and line intensity. The recipe of GF90 overestimates the coolings in the upper chromosphere greatly when temperature exceeds 10^5 K, which also affects the flare evolution and line asymmetries. Radiative heating in the middle chromosphere only functions in the initial stage and could be safely neglected. However, radiative heating from Lyman continuum could dominate near the transition region., 16 pages, 11 figures, 3 tables. A&A accepted
Published: 2022

47. Comparison of second-line on-site computed quantitative flow ratio from coronary computed tomography angiography to PET perfusion imaging for detecting obstructive coronary artery disease

Author: J Dahl, L D Ramussen, D Ding, J Westra, W Wijns, S Tu, E Christiansen, A Eftekhari, L C Gormsen, J A Ejlersen, S Winther, and M Bottcher
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Introduction In patients with suspected obstructive coronary artery disease (CAD) on coronary computed tomography (CTA), guidelines endorse second-line selective testing for hemodynamic evaluation of suspected CAD. A variety of non-invasive modalities are available, and myocardial perfusion imaging with Rubidium-82 positron emission tomography (PET) is an established method with high diagnostic performance. Recently, an on-site method estimating computed tomography-derived quantitative flow ratio (CT-QFR) showed promising results for discriminating obstructive CAD. However, no study has compared the diagnostic performances of PET and CT-QFR. Purpose To assess a possible non-inferiority of CT-QFR compared to PET in patients with suspected obstructive CAD at CTA using invasive coronary angiography (ICA) with fractional flow reserve (FFR) as reference. Methods Patients (n=1732, 57% males, age 59±9.5) referred on a clinical indication with symptoms suggestive of obstructive CAD underwent routine CTA. Patients with ≥50% diameter stenosis (DS) on CTA were referred for PET and subsequent ICA with FFR. CT-QFR was analyzed post-hoc blinded to PET and ICA results. Abnormal CT-QFR was defined as CT-QFR ≤0.80 in any vessel with a diameter ≥1.5mm. An independent core-lab evaluated PET scans as abnormal/normal with optional analyst-dependent application of pre-specified criteria; summed stress score of ≥4 in ≥2 contiguous segments, vessel-specific myocardial blood flow (MBF) 1.13. Obstructive CAD was defined as ICA with FFR ≤0.80 or high-grade stenosis (≥90% DS). Results In total, 445/1732 patients (25%) had suspected obstructive CAD on CTA of whom 400/445 patients (90%) underwent subsequent PET and ICA. CT-QFR was successfully analysed in 383/400 (96%) patients classifying 174/383 (45%) patients as having disease. In comparison, PET classified 130/383 (34%) patients as having disease. In total, obstructive CAD by ICA with FFR was identified in 162 (42%) patients. There was no significant difference in area under the receiver-operating characteristic curves for CT-QFR compared to the best performing PET metric (lowest vessel-specific MBF); 0.84 (95% CI 0.80–0.89) vs. 0.81 (0.77–0.85), p=0.19)) (Fig. 1). Overall diagnostic accuracy of CT-QFR versus PET was similar (78% (95% CI 74–82) vs. 77% (72–81), p=0.70. Sensitivities for CT-QFR and PET were 78% (71–84) and 63% (55–70), p Conclusion In patients with suspected obstructive CAD by CTA, second-line CT-QFR was non-inferior to PET for discriminating obstructive CAD by invasive FFR; Although diagnostic accuracy was similar, CT-QFR demonstrated higher sensitivity while PET showed higher specificity Funding Acknowledgement Type of funding sources: Public Institution(s). Main funding source(s): Aarhus University PhD fellowshipRegion Mid Health Research Foundation
Published: 2022
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48. Murray law-based quantitative flow ratio for assessment of left main bifurcation derived from a single fluoroscopic angiographic view as compared to FFRCT

Author: N Kotoku, D Ding, K Ninomiya, S Masuda, S Kageyama, N Piazza, W Wijns, S Tu, Y Onuma, and P W Serruys
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Background In patients with complex CAD, the presence of left main (LM) disease is an important prognostic factor in assessing the risk balance between PCI and CABG. Functional assessment has become standard of care to evaluate the significance of coronary stenosis and to justify the performance of PCI in the contemporary practice. FFRCT is a well-established method based on 3D reconstruction of coronary artery derived from CCTA. The Murray law-based quantitative flow reserve (μQFR) is a novel computational method of invasive angiography relying on a single angiographic view that takes into account side branches diameters to compute fractal flow division. The aim of the current analysis is to evaluate in patients with complex CAD the feasibility of μQFR in LM bifurcation and its diagnostic concordance with FFRCT. The impact of the optimal viewing angle defined by CCTA on the physiological assessment of the LM bifurcation using a single angiographic view was also evaluated. Methods In 299 consecutive patients with 3-vessel disease with or without LM coronary artery disease, up to 3 analyzable fluoroscopic projections per patient were analysed with μQFR retrospectively. FFRCT and μQFR were measured at 3 fiducial landmark points: i) point of LM bifurcation (POB); ii) proximal LAD 10 mm distal to POB; ii) proximal LCX 10 mm distal to POB. CCTA-based “optimal viewing angle” of LM bifurcation are computed by creating a 3-point closed spline involving the LM, LAD, and LCX at 5mm from the POB and subsequently by reconstructing the “en face” fluoroscopic viewing angle of the spline. The en face viewing angle provides an optimal assessment of the bifurcation geometry [1]. In terms of Rx gantry angulation, the closest angiographic projection to the optimal viewing angle derived from CCTA was defined as the “best fluoroscopic projection” for each patient. Results In 299 patients, 793 projections were analysed with μQFR and compared to FFRCT. Single view μQFR was analyzable in 100%. Correlation and agreement between μQFR and FFRCT for 793 projections in 299 patients are shown in Figure 1A, 2A. The Spearman's correlation coefficient showed moderate correlations at POB (r=0.481, p Conclusion Computation of μQFR from a single angiographic view has a high feasibility. Tailored optimal fluoroscopic view is essential for the physiological assessment of the LM bifurcation using a single angiographic view. Evaluation of diagnostic accuracy of μQFR warrants further analysis of the LMCAD after prospective planning of the optimal fluoroscopic view based on the selection of the best CCTA 3D view. Funding Acknowledgement Type of funding sources: None.
Published: 2022
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49. Heart failure and cardiovascular outcomes in european patients with atrial fibrillation

Author: N Bonini, M Proietti, G F Romiti, M Vitolo, A M Fawzy, Y D Ding, L Fauchier, F Marin, M Nabauer, T S Potpara, G A Dan, G Boriani, and G Y H Lip
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Background Heart failure (HF) has an intimate bidirectional association with atrial fibrillation (AF). Few data are available about the impact of HF phenotypes (HF with preserved ejection fraction, HFpEF; HF with mildly reduced ejection fraction, HFmrEF; HF with reduced ejection fraction, HFrEF) as predictors for adverse outcomes in AF patients. Purpose To investigate the association of HFpEF, HFmrEF and HFrEF with adverse outcomes in a large contemporary cohort of European AF patients and evaluate the effect of EF throughout its entire spectrum. Methods We analyzed patients enrolled in the ESC-EHRA EORP-AF General Long-Term Registry. HF patients were categorized according the three phenotypes and compared to those without HF (“non HF”). Main outcome was a composite outcome of all-cause death and major adverse cardiac events (MACE). Results Among the original 11,096 AF patients enrolled, 9857 (88.8%) were included in this analysis (median age 71 years, interquartile range [IQR 63–77], 40.1% females) with median EF 55% [IQR 45–61%] and CHA2DS2-VASc 3 [2–4]). In this cohort, 5935 (60.2%) were non HF patients, and 3240 (32.9%) had HF patients (with HF status and EF values data available). Accordingly, 1662 (51.2%) were categorized as HFpEF; 523 (14.1%) were HFmrEF; and 1235 (35.1%) were HFrEF. After a median follow-up of 731 days [IQR 690–748], the composite outcome was significantly higher throughout HF categories (HFpEF 19.0%, HFmrEF 21.8% and HFrEF 29.6%, compared to non HF 10.7%; p Conclusions Over a two-years follow-up, in a large contemporary cohort of European AF patients, HF phenotypes were associated with a progressively higher risk for adverse outcomes. Lower EF values increased the risk of adverse outcomes both in HF patients and overall AF patients, irrespective of HF phenotype status. Funding Acknowledgement Type of funding sources: Other. Main funding source(s): Since the start of EORP, the following companies have supported the programme: Abbott Vascular Int. (2011–2021), Amgen Cardiovascular (2009–2018), AstraZeneca (2014–2021), Bayer (2009–2018), Boehringer Ingelheim (2009–2019), Boston Scientific (2009–2012), The Bristol Myers Squibb and Pfizer Alliance (2011–2016), The Alliance Daiichi Sankyo Europe GmbH and Eli Lilly and Company (2011–2017), Edwards (2016–2019), Gedeon Richter Plc. (2014–2017), Menarini Int. Op. (2009–2012), MSD-Merck & Co. (2011–2014), Novartis Pharma AG (2014–2020), ResMed (2014–2016), Sanofi (2009–2011), SERVIER (2010–2021), and Vifor (2019–2022).
Published: 2022
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50. Diagnostic performance of on-site computation of quantitative flow ratio by a coronary computed tomography angiography based algorithm: comparison of distal and lesion-specific measurements

Author: J Dahl, L D Rasmussen, D Ding, J Westra, W Wijns, S Tu, E Christiansen, A Eftekhari, G Li, S Winther, and M Bottcher
Subjects: Cardiology and Cardiovascular Medicine
Abstract: Introduction Guidelines recommend secondary ischemia assessment following a coronary computed tomography angiography (CTA) with suspected obstructive coronary artery disease (CAD). Coronary CTA-derived quantitative flow ratio (CT-QFR) is an on-site technique performed on acquired CTA images that estimates the functional severity of a coronary stenosis. However, CT-QFR measurements are available throughout the coronary vessel with no clear recommendations as to which specific values should be used for identifying obstructive CAD, e.g. most distal or lesion-specific values. Purpose First, to investigate the feasibility of CT-QFR and the correlation and agreement with invasive fractional flow reserve (FFR). Secondly, to compare the diagnostic performance of distal versus lesion-specific CT-QFR for identifying obstructive CAD defined by invasive coronary angiography (ICA) with FFR. Methods A total of 1732 prospectively included patients with symptoms suggestive of CAD referred for CTA were included. All patients with ≥50% diameter stenosis (DS) on CTA were subsequently referred for ICA with conditional FFR in lesions with 30–89%DS. Obstructive CAD was defined by ICA as FFR ≤0.80 or high-grade stenosis by visual assessment (≥90%DS). A blinded analysis of CT-QFR was performed in patients referred to ICA with measurements at the distal end of a vessel (distal CT-QFR) and 1 cm distal to stenotic lesions on CTA (lesion-specific). CT-QFR ≤0.80 was defined as abnormal. For correlation analyses to invasive FFR, CT-QFR was assessed corresponding to the position of the invasive pressure sensor. Results In total, 445/1732 (25%) patients had suspected obstructive CAD at CTA and underwent subsequent ICA. CT-QFR analysis was feasible in 423/445 (95%) patients. CT-QFR correlated (Pearson's rho 0.54, p Conclusion In patients with suspected obstructive CAD on CTA, non-invasive estimation of FFR using CT-QFR is feasible with moderate correlation and good agreement with invasive FFR. Overall diagnostic performance of distal and lesion-specific values for discriminating obstructive CAD by invasive FFR are similar. The use of CT-QFR could therefore potentially reduce the need for referral to invasive angiography after CTA. Funding Acknowledgement Type of funding sources: Public Institution(s). Main funding source(s): Aarhus UniversityRegion Mid Jutland
Published: 2022
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