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24 results on '"D Arrigo, G"'

2. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants

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Zhou, B, Bentham, J, Di Cesare, M, Bixby, H, Danaei, G, Cowan, MJ, Paciorek, CJ, Singh, G, Hajifathalian, K, Bennett, JE, Taddei, C, Bilano, V, Carrillo-Larco, RM, Djalalinia, S, Khatibzadeh, S, Lugero, C, Peykari, N, Zhang, WZ, Lu, Y, Stevens, GA, Riley, LM, Bovet, P, Elliott, P, Gu, D, Ikeda, N, Jackson, RT, Joffres, M, Kengne, AP, Laatikainen, T, Lam, TH, Laxmaiah, A, Liu, J, Miranda, JJ, Mondo, CK, Neuhauser, HK, Sundström, J, Smeeth, L, Soric, M, Woodward, M, Ezzati, M, Abarca-Gómez, L, Abdeen, ZA, Rahim, HA, Abu-Rmeileh, NM, Acosta-Cazares, B, Adams, R, Aekplakorn, W, Afsana, K, Aguilar-Salinas, CA, Agyemang, C, Ahmadvand, A, Ahrens, W, Al Raddadi, R, Al Woyatan, R, Ali, MM, Alkerwi, A, Aly, E, Amouyel, P, Amuzu, A, Andersen, LB, Anderssen, SA, Ängquist, L, Anjana, RM, Ansong, D, Aounallah-Skhiri, H, Araújo, J, Ariansen, I, Aris, T, Arlappa, N, Aryal, K, Arveiler, D, Assah, FK, Assun ao, MCF, Avdicová, M, Azevedo, A, Azizi, F, Babu, BV, Bahijri, S, Balakrishna, N, Bandosz, P, Banegas, JR, Barbagallo, CM, Barceló, A, Barkat, A, Barros, AJD, Barros, MV, Bata, I, Batieha, AM, Baur, LA, Beaglehole, R, Romdhane, HB, Benet, M, Benson, LS, Bernabe-Ortiz, A, Bernotiene, G, Bettiol, H, Bhagyalaxmi, A, Bharadwaj, S, Bhargava, SK, Bi, Y, Bikbov, M, Bjerregaard, P, Bjertness, E, Björkelund, C, Blokstra, A, Bo, S, Bobak, M, Boeing, H, Boggia, JG, Boissonnet, CP, Bongard, V, Braeckman, L, Brajkovich, I, Branca, F, Breckenkamp, J, Brenner, H, Brewster, LM, Bruno, G, Bueno-de-Mesquita, HB, Bugge, A, Burns, C, Bursztyn, M, de León, AC, Cacciottolo, J, Cameron, C, Can, G, Cândido, APC, Capuano, V, Cardoso, VC, Carlsson, AC, Carvalho, MJ, Casanueva, FF, Casas, J-P, Caserta, CA, Chamukuttan, S, Chan, AW, Chan, Q, Chaturvedi, HK, Chaturvedi, N, Chen, C-J, Chen, F, Chen, H, Chen, S, Chen, Z, Cheng, C-Y, Dekkaki, IC, Chetrit, A, Chiolero, A, Chiou, S-T, Chirita-Emandi, A, Cho, B, Cho, Y, Chudek, J, Cifkova, R, Claessens, F, Clays, E, Concin, H, Cooper, C, Cooper, R, Coppinger, TC, Costanzo, S, Cottel, D, Cowell, C, Craig, CL, Crujeiras, AB, Cruz, JJ, D Arrigo, G, d Orsi, E, Dallongeville, J, Damasceno, A, Dankner, R, Dantoft, TM, Dauchet, L, De Backer, G, De Bacquer, D, de Gaetano, G, De Henauw, S, De Smedt, D, Deepa, M, Dehghan, A, Delisle, H, Deschamps, V, Dhana, K, Di Castelnuovo, AF, Dias-da-Costa, JS, Diaz, A, Dickerson, TT, Do, HTP, Dobson, AJ, Donfrancesco, C, Donoso, SP, Döring, A, Doua, K, Drygas, W, Dulskiene, V, D akula, A, Dzerve, V, Dziankowska-Zaborszczyk, E, Eggertsen, R, Ekelund, U, El Ati, J, Ellert, U, Elosua, R, Erasmus, RT, Erem, C, Eriksen, L, Escobedo-de la Pe na, J, Evans, A, Faeh, D, Fall, CH, Farzadfar, F, Felix-Redondo, FJ, Ferguson, TS, Fernández-Bergés, D, Ferrante, D, Ferrari, M, Ferreccio, C, Ferrieres, J, Finn, JD, Fischer, K, Föger, B, Foo, LH, Forslund, A-S, Forsner, M, Fortmann, SP, Fouad, HM, Francis, DK, do Carmo Franco, M, Franco, OH, Frontera, G, Fuchs, FD, Fuchs, SC, Fujita, Y, Furusawa, T, Gaciong, Z, Gareta, D, Garnett, SP, Gaspoz, J-M, Gasull, M, Gates, L, Gavrila, D, Geleijnse, JM, Ghasemian, A, Ghimire, A, Giampaoli, S, Gianfagna, F, Giovannelli, J, Goldsmith, RA, Gon alves, H, Gross, MG, González Rivas, JP, Gottrand, F, Graff-Iversen, S, Grafnetter, D, Grajda, A, Gregor, RD, Grodzicki, T, Grøntved, A, Gruden, G, Grujic, V, Guan, OP, Gudnason, V, Guerrero, R, Guessous, I, Guimaraes, AL, Gulliford, MC, Gunnlaugsdottir, J, Gunter, M, Gupta, PC, Gureje, O, Gurzkowska, B, Gutierrez, L, Gutzwiller, F, Hadaegh, F, Halkj r, J, Hambleton, IR, Hardy, R, Harikumar, R, Hata, J, Hayes, AJ, He, J, Hendriks, ME, Henriques, A, Cadena, LH, Herqutanto, Herrala, S, Heshmat, R, Hihtaniemi, IT, Ho, SY, Ho, SC, Hobbs, M, Hofman, A, Dinc, GH, Hormiga, CM, Horta, BL, Houti, L, Howitt, C, Htay, TT, Htet, AS, Hu, Y, Huerta, JM, Husseini, AS, Huybrechts, I, Hwalla, N, Iacoviello, L, Iannone, AG, Ibrahim, MM, Ikram, MA, Irazola, VE, Islam, M, Ivkovic, V, Iwasaki, M, Jacobs, JM, Jafar, T, Jamrozik, K, Janszky, I, Jasienska, G, Jelakovic, B, Jiang, CQ, Johansson, M, Jonas, JB, J rgensen, T, Joshi, P, Juolevi, A, Jurak, G, Jure a, V, Kaaks, R, Kafatos, A, Kalter-Leibovici, O, Kamaruddin, NA, Kasaeian, A, Katz, J, Kauhanen, J, Kaur, P, Kavousi, M, Kazakbaeva, G, Keil, U, Boker, LK, Keinänen-Kiukaanniemi, S, Kelishadi, R, Kemper, HCG, Kersting, M, Key, T, Khader, YS, Khalili, D, Khang, Y-H, Khaw, K-T, Kiechl, S, Killewo, J, Kim, J, Klumbiene, J, Kolle, E, Kolsteren, P, Korrovits, P, Koskinen, S, Kouda, K, Koziel, S, Kristensen, PL, Krokstad, S, Kromhout, D, Kruger, HS, Kubinova, R, Kuciene, R, Kuh, D, Kujala, UM, Kula, K, Kulaga, Z, Krishna Kumar, R, Kurjata, P, Kusuma, YS, Kuulasmaa, K, Kyobutungi, C, Lachat, C, Landrove, O, Lanska, V, Lappas, G, Larijani, B, Laugsand, LE, Le Nguyen Bao, K, Le, TD, Leclercq, C, Lee, J, Lehtimäki, T, Lekhraj, R, León-Mu noz, LM, Levitt, NS, Li, Y, Lilly, CL, Lim, W-Y, Lima-Costa, MF, Lin, H-H, Lin, X, Linneberg, A, Lissner, L, Litwin, M, Lorbeer, R, Lotufo, PA, Lozano, JE, Luksiene, D, Lundqvist, A, Lunet, N, Lytsy, P, Ma, G, Ma, J, Machado-Coelho, GLL, Machi, S, Maggi, S, Magliano, DJ, Majer, M, Makdisse, M, Malekzadeh, R, Malhotra, R, Rao, KM, Malyutina, S, Manios, Y, Mann, JI, Manzato, E, Margozzini, P, Marques-Vidal, P, Marrugat, J, Martorell, R, Mathiesen, EB, Matijasevich, A, Matsha, TE, Mbanya, JCN, McDonald Posso, AJ, McFarlane, SR, McGarvey, ST, McLachlan, S, McLean, RM, McNulty, BA, MdKhir, AS, Mediene-Benchekor, S, Medzioniene, J, Meirhaeghe, A, Meisinger, C, Menezes, AMB, Menon, GR, Meshram, II, Metspalu, A, Mi, J, Mikkel, K, Miller, JC, Miquel, JF, Mi igoj-Durakovic, M, Mohamed, MK, Mohammad, K, Mohammadifard, N, Mohan, V, Mohd Yusoff, MF, M ller, NC, Molnár, D, Momenan, A, Monyeki, KDK, Moreira, LB, Morejon, A, Moreno, LA, Morgan, K, Moschonis, G, Mossakowska, M, Mostafa, A, Mota, J, Motlagh, ME, Motta, J, Muiesan, ML, Müller-Nurasyid, M, Murphy, N, Mursu, J, Musil, V, Nagel, G, Naidu, BM, Nakamura, H, Náme ná, J, Nang, EEK, Nangia, VB, Narake, S, Navarrete-Mu noz, EM, Ndiaye, NC, Neal, WA, Nenko, I, Nervi, F, Nguyen, ND, Nguyen, QN, Nieto-Martínez, RE, Niiranen, TJ, Ning, G, Ninomiya, T, Nishtar, S, Noale, M, Noboa, OA, Noorbala, AA, Norat, T, Noto, D, Al Nsour, M, O Reilly, D, Oh, K, Olinto, MTA, Oliveira, IO, Omar, MA, Onat, A, Ordunez, P, Osmond, C, Ostojic, SM, Otero, JA, Overvad, K, Owusu-Dabo, E, Paccaud, FM, Padez, C, Pahomova, E, Pajak, A, Palli, D, Palmieri, L, Panda-Jonas, S, Panza, F, Papandreou, D, Parnell, WR, Parsaeian, M, Pecin, I, Pednekar, MS, Peer, N, Peeters, PH, Peixoto, SV, Pelletier, C, Peltonen, M, Pereira, AC, Pérez, RM, Peters, A, Petkeviciene, J, Pham, ST, Pigeot, I, Pikhart, H, Pilav, A, Pilotto, L, Pitakaka, F, Plans-Rubió, P, Polakowska, M, Pola ek, O, Porta, M, Portegies, MLP, Pourshams, A, Pradeepa, R, Prashant, M, Price, JF, Puiu, M, Punab, M, Qasrawi, RF, Qorbani, M, Radic, I, Radisauskas, R, Rahman, M, Raitakari, O, Raj, M, Rao, SR, Ramachandran, A, Ramos, E, Rampal, S, Rangel Reina, DA, Rasmussen, F, Redon, J, Reganit, PFM, Ribeiro, R, Riboli, E, Rigo, F, Rinke de Wit, TF, Ritti-Dias, RM, Robinson, SM, Robitaille, C, Rodríguez-Artalejo, F, del Cristo Rodriguez-Perez, M, Rodríguez-Villamizar, LA, Rojas-Martinez, R, Rosengren, A, Rubinstein, A, Rui, O, Ruiz-Betancourt, BS, Russo Horimoto, ARV, Rutkowski, M, Sabanayagam, C, Sachdev, HS, Saidi, O, Sakarya, S, Salanave, B, Martinez, ES, Salmerón, D, Salomaa, V, Salonen, JT, Salvetti, M, Sánchez-Abanto, J, Sans, S, Santos, D, Santos, IS, dos Santos, RN, Santos, R, Saramies, JL, Sardinha, LB, Margolis, GS, Sarrafzadegan, N, Saum, K-U, Savva, SC, Scazufca, M, Schargrodsky, H, Schneider, IJ, Schultsz, C, Schutte, AE, Sen, A, Senbanjo, IO, Sepanlou, SG, Sharma, SK, Shaw, JE, Shibuya, K, Shin, DW, Shin, Y, Siantar, R, Sibai, AM, Santos Silva, DA, Simon, M, Simons, J, Simons, LA, Sjöström, M, Skovbjerg, S, Slowikowska-Hilczer, J, Slusarczyk, P, Smith, MC, Snijder, MB, So, H-K, Sobngwi, E, Söderberg, S, Solfrizzi, V, Sonestedt, E, Song, Y, S rensen, TIA, Jérome, CS, Soumare, A, Staessen, JA, Starc, G, Stathopoulou, MG, Stavreski, B, Steene-Johannessen, J, Stehle, P, Stein, AD, Stergiou, GS, Stessman, J, Stieber, J, Stöckl, D, Stocks, T, Stokwiszewski, J, Stronks, K, Strufaldi, MW, Sun, C-A, Sung, Y-T, Suriyawongpaisal, P, Sy, RG, Tai, ES, Tammesoo, M-L, Tamosiunas, A, Tang, L, Tang, X, Tanser, F, Tao, Y, Tarawneh, MR, Tarqui-Mamani, CB, Taylor, A, Theobald, H, Thijs, L, Thuesen, BH, Tjonneland, A, Tolonen, HK, Tolstrup, JS, Topbas, M, Topór-Madry, R, Tormo, MJ, Torrent, M, Traissac, P, Trichopoulos, D, Trichopoulou, A, Trinh, OTH, Trivedi, A, Tshepo, L, Tulloch-Reid, MK, Tuomainen, T-P, Tuomilehto, J, Turley, ML, Tynelius, P, Tzourio, C, Ueda, P, Ugel, E, Ulmer, H, Uusitalo, HMT, Valdivia, G, Valvi, D, van der Schouw, YT, Van Herck, K, van Rossem, L, van Valkengoed, IGM, Vanderschueren, D, Vanuzzo, D, Vatten, L, Vega, T, Velasquez-Melendez, G, Veronesi, G, Verschuren, WMM, Verstraeten, R, Victora, CG, Viet, L, Viikari-Juntura, E, Vineis, P, Vioque, J, Virtanen, JK, Visvikis-Siest, S, Viswanathan, B, Vollenweider, P, Voutilainen, S, Vrdoljak, A, Vrijheid, M, Wade, AN, Wagner, A, Walton, J, Wan Mohamud, WN, Wang, M-D, Wang, Q, Wang, YX, Wannamethee, SG, Wareham, N, Wederkopp, N, Weerasekera, D, Whincup, PH, Widhalm, K, Widyahening, IS, Wiecek, A, Wijga, AH, Wilks, RJ, Willeit, J, Willeit, P, Williams, EA, Wilsgaard, T, Wojtyniak, B, Wong, TY, Wong-McClure, RA, Woo, J, Wu, AG, Wu, FC, Wu, SL, Xu, H, Yan, W, Yang, X, Ye, X, Yiallouros, PK, Yoshihara, A, Younger-Coleman, NO, Yusoff, AF, Yusoff, MFM, Zambon, S, Zdrojewski, T, Zeng, Y, Zhao, D, Zhao, W, Zheng, Y, Zhu, D, Zimmermann, E, Cisneros, JZ, Zhou, B, Bentham, J, Di Cesare, M, Bixby, H, Danaei, G, Cowan, MJ, Paciorek, CJ, Singh, G, Hajifathalian, K, Bennett, JE, Taddei, C, Bilano, V, Carrillo-Larco, RM, Djalalinia, S, Khatibzadeh, S, Lugero, C, Peykari, N, Zhang, WZ, Lu, Y, Stevens, GA, Riley, LM, Bovet, P, Elliott, P, Gu, D, Ikeda, N, Jackson, RT, Joffres, M, Kengne, AP, Laatikainen, T, Lam, TH, Laxmaiah, A, Liu, J, Miranda, JJ, Mondo, CK, Neuhauser, HK, Sundström, J, Smeeth, L, Soric, M, Woodward, M, Ezzati, M, Abarca-Gómez, L, Abdeen, ZA, Rahim, HA, Abu-Rmeileh, NM, Acosta-Cazares, B, Adams, R, Aekplakorn, W, Afsana, K, Aguilar-Salinas, CA, Agyemang, C, Ahmadvand, A, Ahrens, W, Al Raddadi, R, Al Woyatan, R, Ali, MM, Alkerwi, A, Aly, E, Amouyel, P, Amuzu, A, Andersen, LB, Anderssen, SA, Ängquist, L, Anjana, RM, Ansong, D, Aounallah-Skhiri, H, Araújo, J, Ariansen, I, Aris, T, Arlappa, N, Aryal, K, Arveiler, D, Assah, FK, Assun ao, MCF, Avdicová, M, Azevedo, A, Azizi, F, Babu, BV, Bahijri, S, Balakrishna, N, Bandosz, P, Banegas, JR, Barbagallo, CM, Barceló, A, Barkat, A, Barros, AJD, Barros, MV, Bata, I, Batieha, AM, Baur, LA, Beaglehole, R, Romdhane, HB, Benet, M, Benson, LS, Bernabe-Ortiz, A, Bernotiene, G, Bettiol, H, Bhagyalaxmi, A, Bharadwaj, S, Bhargava, SK, Bi, Y, Bikbov, M, Bjerregaard, P, Bjertness, E, Björkelund, C, Blokstra, A, Bo, S, Bobak, M, Boeing, H, Boggia, JG, Boissonnet, CP, Bongard, V, Braeckman, L, Brajkovich, I, Branca, F, Breckenkamp, J, Brenner, H, Brewster, LM, Bruno, G, Bueno-de-Mesquita, HB, Bugge, A, Burns, C, Bursztyn, M, de León, AC, Cacciottolo, J, Cameron, C, Can, G, Cândido, APC, Capuano, V, Cardoso, VC, Carlsson, AC, Carvalho, MJ, Casanueva, FF, Casas, J-P, Caserta, CA, Chamukuttan, S, Chan, AW, Chan, Q, Chaturvedi, HK, Chaturvedi, N, Chen, C-J, Chen, F, Chen, H, Chen, S, Chen, Z, Cheng, C-Y, Dekkaki, IC, Chetrit, A, Chiolero, A, Chiou, S-T, Chirita-Emandi, A, Cho, B, Cho, Y, Chudek, J, Cifkova, R, Claessens, F, Clays, E, Concin, H, Cooper, C, Cooper, R, Coppinger, TC, Costanzo, S, Cottel, D, Cowell, C, Craig, CL, Crujeiras, AB, Cruz, JJ, D Arrigo, G, d Orsi, E, Dallongeville, J, Damasceno, A, Dankner, R, Dantoft, TM, Dauchet, L, De Backer, G, De Bacquer, D, de Gaetano, G, De Henauw, S, De Smedt, D, Deepa, M, Dehghan, A, Delisle, H, Deschamps, V, Dhana, K, Di Castelnuovo, AF, Dias-da-Costa, JS, Diaz, A, Dickerson, TT, Do, HTP, Dobson, AJ, Donfrancesco, C, Donoso, SP, Döring, A, Doua, K, Drygas, W, Dulskiene, V, D akula, A, Dzerve, V, Dziankowska-Zaborszczyk, E, Eggertsen, R, Ekelund, U, El Ati, J, Ellert, U, Elosua, R, Erasmus, RT, Erem, C, Eriksen, L, Escobedo-de la Pe na, J, Evans, A, Faeh, D, Fall, CH, Farzadfar, F, Felix-Redondo, FJ, Ferguson, TS, Fernández-Bergés, D, Ferrante, D, Ferrari, M, Ferreccio, C, Ferrieres, J, Finn, JD, Fischer, K, Föger, B, Foo, LH, Forslund, A-S, Forsner, M, Fortmann, SP, Fouad, HM, Francis, DK, do Carmo Franco, M, Franco, OH, Frontera, G, Fuchs, FD, Fuchs, SC, Fujita, Y, Furusawa, T, Gaciong, Z, Gareta, D, Garnett, SP, Gaspoz, J-M, Gasull, M, Gates, L, Gavrila, D, Geleijnse, JM, Ghasemian, A, Ghimire, A, Giampaoli, S, Gianfagna, F, Giovannelli, J, Goldsmith, RA, Gon alves, H, Gross, MG, González Rivas, JP, Gottrand, F, Graff-Iversen, S, Grafnetter, D, Grajda, A, Gregor, RD, Grodzicki, T, Grøntved, A, Gruden, G, Grujic, V, Guan, OP, Gudnason, V, Guerrero, R, Guessous, I, Guimaraes, AL, Gulliford, MC, Gunnlaugsdottir, J, Gunter, M, Gupta, PC, Gureje, O, Gurzkowska, B, Gutierrez, L, Gutzwiller, F, Hadaegh, F, Halkj r, J, Hambleton, IR, Hardy, R, Harikumar, R, Hata, J, Hayes, AJ, He, J, Hendriks, ME, Henriques, A, Cadena, LH, Herqutanto, Herrala, S, Heshmat, R, Hihtaniemi, IT, Ho, SY, Ho, SC, Hobbs, M, Hofman, A, Dinc, GH, Hormiga, CM, Horta, BL, Houti, L, Howitt, C, Htay, TT, Htet, AS, Hu, Y, Huerta, JM, Husseini, AS, Huybrechts, I, Hwalla, N, Iacoviello, L, Iannone, AG, Ibrahim, MM, Ikram, MA, Irazola, VE, Islam, M, Ivkovic, V, Iwasaki, M, Jacobs, JM, Jafar, T, Jamrozik, K, Janszky, I, Jasienska, G, Jelakovic, B, Jiang, CQ, Johansson, M, Jonas, JB, J rgensen, T, Joshi, P, Juolevi, A, Jurak, G, Jure a, V, Kaaks, R, Kafatos, A, Kalter-Leibovici, O, Kamaruddin, NA, Kasaeian, A, Katz, J, Kauhanen, J, Kaur, P, Kavousi, M, Kazakbaeva, G, Keil, U, Boker, LK, Keinänen-Kiukaanniemi, S, Kelishadi, R, Kemper, HCG, Kersting, M, Key, T, Khader, YS, Khalili, D, Khang, Y-H, Khaw, K-T, Kiechl, S, Killewo, J, Kim, J, Klumbiene, J, Kolle, E, Kolsteren, P, Korrovits, P, Koskinen, S, Kouda, K, Koziel, S, Kristensen, PL, Krokstad, S, Kromhout, D, Kruger, HS, Kubinova, R, Kuciene, R, Kuh, D, Kujala, UM, Kula, K, Kulaga, Z, Krishna Kumar, R, Kurjata, P, Kusuma, YS, Kuulasmaa, K, Kyobutungi, C, Lachat, C, Landrove, O, Lanska, V, Lappas, G, Larijani, B, Laugsand, LE, Le Nguyen Bao, K, Le, TD, Leclercq, C, Lee, J, Lehtimäki, T, Lekhraj, R, León-Mu noz, LM, Levitt, NS, Li, Y, Lilly, CL, Lim, W-Y, Lima-Costa, MF, Lin, H-H, Lin, X, Linneberg, A, Lissner, L, Litwin, M, Lorbeer, R, Lotufo, PA, Lozano, JE, Luksiene, D, Lundqvist, A, Lunet, N, Lytsy, P, Ma, G, Ma, J, Machado-Coelho, GLL, Machi, S, Maggi, S, Magliano, DJ, Majer, M, Makdisse, M, Malekzadeh, R, Malhotra, R, Rao, KM, Malyutina, S, Manios, Y, Mann, JI, Manzato, E, Margozzini, P, Marques-Vidal, P, Marrugat, J, Martorell, R, Mathiesen, EB, Matijasevich, A, Matsha, TE, Mbanya, JCN, McDonald Posso, AJ, McFarlane, SR, McGarvey, ST, McLachlan, S, McLean, RM, McNulty, BA, MdKhir, AS, Mediene-Benchekor, S, Medzioniene, J, Meirhaeghe, A, Meisinger, C, Menezes, AMB, Menon, GR, Meshram, II, Metspalu, A, Mi, J, Mikkel, K, Miller, JC, Miquel, JF, Mi igoj-Durakovic, M, Mohamed, MK, Mohammad, K, Mohammadifard, N, Mohan, V, Mohd Yusoff, MF, M ller, NC, Molnár, D, Momenan, A, Monyeki, KDK, Moreira, LB, Morejon, A, Moreno, LA, Morgan, K, Moschonis, G, Mossakowska, M, Mostafa, A, Mota, J, Motlagh, ME, Motta, J, Muiesan, ML, Müller-Nurasyid, M, Murphy, N, Mursu, J, Musil, V, Nagel, G, Naidu, BM, Nakamura, H, Náme ná, J, Nang, EEK, Nangia, VB, Narake, S, Navarrete-Mu noz, EM, Ndiaye, NC, Neal, WA, Nenko, I, Nervi, F, Nguyen, ND, Nguyen, QN, Nieto-Martínez, RE, Niiranen, TJ, Ning, G, Ninomiya, T, Nishtar, S, Noale, M, Noboa, OA, Noorbala, AA, Norat, T, Noto, D, Al Nsour, M, O Reilly, D, Oh, K, Olinto, MTA, Oliveira, IO, Omar, MA, Onat, A, Ordunez, P, Osmond, C, Ostojic, SM, Otero, JA, Overvad, K, Owusu-Dabo, E, Paccaud, FM, Padez, C, Pahomova, E, Pajak, A, Palli, D, Palmieri, L, Panda-Jonas, S, Panza, F, Papandreou, D, Parnell, WR, Parsaeian, M, Pecin, I, Pednekar, MS, Peer, N, Peeters, PH, Peixoto, SV, Pelletier, C, Peltonen, M, Pereira, AC, Pérez, RM, Peters, A, Petkeviciene, J, Pham, ST, Pigeot, I, Pikhart, H, Pilav, A, Pilotto, L, Pitakaka, F, Plans-Rubió, P, Polakowska, M, Pola ek, O, Porta, M, Portegies, MLP, Pourshams, A, Pradeepa, R, Prashant, M, Price, JF, Puiu, M, Punab, M, Qasrawi, RF, Qorbani, M, Radic, I, Radisauskas, R, Rahman, M, Raitakari, O, Raj, M, Rao, SR, Ramachandran, A, Ramos, E, Rampal, S, Rangel Reina, DA, Rasmussen, F, Redon, J, Reganit, PFM, Ribeiro, R, Riboli, E, Rigo, F, Rinke de Wit, TF, Ritti-Dias, RM, Robinson, SM, Robitaille, C, Rodríguez-Artalejo, F, del Cristo Rodriguez-Perez, M, Rodríguez-Villamizar, LA, Rojas-Martinez, R, Rosengren, A, Rubinstein, A, Rui, O, Ruiz-Betancourt, BS, Russo Horimoto, ARV, Rutkowski, M, Sabanayagam, C, Sachdev, HS, Saidi, O, Sakarya, S, Salanave, B, Martinez, ES, Salmerón, D, Salomaa, V, Salonen, JT, Salvetti, M, Sánchez-Abanto, J, Sans, S, Santos, D, Santos, IS, dos Santos, RN, Santos, R, Saramies, JL, Sardinha, LB, Margolis, GS, Sarrafzadegan, N, Saum, K-U, Savva, SC, Scazufca, M, Schargrodsky, H, Schneider, IJ, Schultsz, C, Schutte, AE, Sen, A, Senbanjo, IO, Sepanlou, SG, Sharma, SK, Shaw, JE, Shibuya, K, Shin, DW, Shin, Y, Siantar, R, Sibai, AM, Santos Silva, DA, Simon, M, Simons, J, Simons, LA, Sjöström, M, Skovbjerg, S, Slowikowska-Hilczer, J, Slusarczyk, P, Smith, MC, Snijder, MB, So, H-K, Sobngwi, E, Söderberg, S, Solfrizzi, V, Sonestedt, E, Song, Y, S rensen, TIA, Jérome, CS, Soumare, A, Staessen, JA, Starc, G, Stathopoulou, MG, Stavreski, B, Steene-Johannessen, J, Stehle, P, Stein, AD, Stergiou, GS, Stessman, J, Stieber, J, Stöckl, D, Stocks, T, Stokwiszewski, J, Stronks, K, Strufaldi, MW, Sun, C-A, Sung, Y-T, Suriyawongpaisal, P, Sy, RG, Tai, ES, Tammesoo, M-L, Tamosiunas, A, Tang, L, Tang, X, Tanser, F, Tao, Y, Tarawneh, MR, Tarqui-Mamani, CB, Taylor, A, Theobald, H, Thijs, L, Thuesen, BH, Tjonneland, A, Tolonen, HK, Tolstrup, JS, Topbas, M, Topór-Madry, R, Tormo, MJ, Torrent, M, Traissac, P, Trichopoulos, D, Trichopoulou, A, Trinh, OTH, Trivedi, A, Tshepo, L, Tulloch-Reid, MK, Tuomainen, T-P, Tuomilehto, J, Turley, ML, Tynelius, P, Tzourio, C, Ueda, P, Ugel, E, Ulmer, H, Uusitalo, HMT, Valdivia, G, Valvi, D, van der Schouw, YT, Van Herck, K, van Rossem, L, van Valkengoed, IGM, Vanderschueren, D, Vanuzzo, D, Vatten, L, Vega, T, Velasquez-Melendez, G, Veronesi, G, Verschuren, WMM, Verstraeten, R, Victora, CG, Viet, L, Viikari-Juntura, E, Vineis, P, Vioque, J, Virtanen, JK, Visvikis-Siest, S, Viswanathan, B, Vollenweider, P, Voutilainen, S, Vrdoljak, A, Vrijheid, M, Wade, AN, Wagner, A, Walton, J, Wan Mohamud, WN, Wang, M-D, Wang, Q, Wang, YX, Wannamethee, SG, Wareham, N, Wederkopp, N, Weerasekera, D, Whincup, PH, Widhalm, K, Widyahening, IS, Wiecek, A, Wijga, AH, Wilks, RJ, Willeit, J, Willeit, P, Williams, EA, Wilsgaard, T, Wojtyniak, B, Wong, TY, Wong-McClure, RA, Woo, J, Wu, AG, Wu, FC, Wu, SL, Xu, H, Yan, W, Yang, X, Ye, X, Yiallouros, PK, Yoshihara, A, Younger-Coleman, NO, Yusoff, AF, Yusoff, MFM, Zambon, S, Zdrojewski, T, Zeng, Y, Zhao, D, Zhao, W, Zheng, Y, Zhu, D, Zimmermann, E, and Cisneros, JZ

Abstract

Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of raised blood pressure for 200 countries. We calculated the contributions of changes in prevalence versus population growth and ageing to the increase in the number of adults with raised blood pressure. Findings We pooled 1479 studies that had measured the blood pressures of 19·1 million adults. Global age-standardised mean systolic blood pressure in 2015 was 127·0 mm Hg (95% credible interval 125·7–128·3) in men and 122·3 mm Hg (121·0–123·6) in women; age-standardised mean diastolic blood pressure was 78·7 mm Hg (77·9–79·5) for men and 76·7 mm Hg (75·9–77·6) for women. Global age-standardised prevalence of raised blood pressure was 24·1% (21·4–27·1) in men and 20·1% (17·8–22·5) in women in 2015. Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. Mean blood pressure also decreased in women in central and eastern Europe, Latin America and the Caribbean, and, more recently, central Asia, Middle East, and north Africa, but the estimated trends in these super-regions had larger uncertainty than in high-income super-regions. By contrast, mean blood pressure might have increased in east and so

Published
2017

3. Non-mycotic anastomotic pseudoaneurysm of renal allograft artery. Case Report

Author

Ardita, V., Veroux, M., Zerbo, D., D Arrigo, G., Caglià, P., and Veroux, P.

Subjects
Deceased donor, Anastomosis, Surgical, Middle Aged, Allografts, Aneurysm, Iliac Artery, Kidney Transplantation, Femoral Artery, Imaging, Three-Dimensional, Postoperative Complications, Renal Artery, Humans, Female, Vascular Grafting, Kidney transplantation, Emergencies, Ultrasonography, Doppler, Color, Tomography, X-Ray Computed, Aneurysm, False
Abstract

Vascular complications after kidney transplantation are uncommon, and in most cases they present in the early post-transplant period. Anastomotic pseudo-aneurysms usually involve the renal transplant artery anastomosis and in most cases are the consequence of a mycotic contamination during organ recovery or handling of the graft. We report the case of a 61 year-old woman, who presented, eight months after successful kidney transplantation from a deceased donor, with mild pain in the right iliac fossa. Graft sonography and computed tomography scan demonstrated a 33-mm pseudo-aneurysm of the transplant renal artery at the anastomotic site with the external iliac artery. The patient underwent an emergent surgical intervention with resection of the pseudo-aneurysm. Renal transplant artery was re-perfused with a by-pass with the internal iliac artery, while the common iliac artery was revascularized through an autologous vein by-pass between the proximal external iliac artery and the common femoral artery. Postoperative course was complicated by inguinal lymphorrea, with complete resolution on postoperative day 22. Histopathologic examination of the pseudo-aneurysm wall did not reveal any sign of mycotic infection. At 6-month follow-up, graft function was stable and graft sonography demonstrated the patency of iliac-femoral by-pass and a normal renal graft perfusion. In conclusion, pseudo-aneurysm of the renal transplant artery is a rare but potentially life-threatening complication of kidney transplantation, occurring even in the late post-transplant period. Surgical resection of the pseudo-aneurysm, although challenging, may be a valuable option for definitive treatment of the pseudo-aneurysm, while preserving the renal graft function.Aneurysm, Deceased donor, Kidney transplantation, Pseudo-aneurysm, Renal artery Surgery, Vascular complications.Le complicanze vascolari dopo il trapianto renale non sono comuni, e nella maggior parte dei casi si presentano nel periodo post-trapianto precoce. Gli pseudoaneurismi arteriosi coinvolgono l’anastomosi arteriosa del rene trapiantato e nella maggior parte dei casi riconoscono una eziologia micotica. Una donna di 62 anni, che è stata sottoposta otto mesi prima ad un trapianto renale, presentava un vago dolore in fossa iliaca destra. L’ecografia del rene trapiantato dimostrava la presenza di un’area ipoecogena in corrispondenza dell’ilo renale, che all’ecocolordoppler appariva riccamente vascolarizzata. La tomografia computerizzata confermava la diagnosi di pseudo-aneurisma anastomotico di 33 mm di diametro, coinvolgente l’arteria del rene trapiantato. La paziente è stata dunque sottoposta a intervento chirurgico di aneurismectomia, con successivo bypass fra arteria renale del rene trapiantato e arteria iliaca interna. La continuità arteriosa iliaca è stata dunque ristabilita attraverso un by-pass iliaco-esterno-femorale comune in vena safena invertita. L’ecocolordoppler intraoperatorio dimostrava la corretta perfusione del graft renale e la corretta pervietà del by-pass iliacofemorale. Il decorso post-operatorio è stato privo di complicanze significative, eccettuata una linforrea inguinale risolta spontaneamente in 22a giornata post-operatoria. Sei mesi dopo la procedura, la paziente è in ottime condizioni generali, con una funzionalità renale conservata e una corretta pervietà del by-pass iliacofemorale. Lo pseudo-aneurisma dell’arteria renale rappresenta una rara complicanza del trapianto renale. Nella maggior parte dei casi riconosce una eziologia micotica, spesso a causa di contaminazione diretta del graft durante le procedure di prelievo o conservazione dell’organo. Il trattamento è molto complesso, e in molti casi richiede l’espianto del graft. Tuttavia, in alcuni casi selezionati, è possibile eseguire il trattamento dell’aneurisma, preservando il rene trapiantato, come nel caso da noi descritto. In conclusione, lo pseudoaneurisma dell’arteria renale è una complicanza rara ma potenzialmente letale del trapianto renale. L’intervento chirurgico di resezione dell’aneurisma, sebbene tecnicamente complesso, consente di preservare la funzionalità del rene trapiantato.

Published
2016

4. Worldwide trends in diabetes since 1980: A pooled analysis of 751 population-based studies with 4.4 million participants

Author

Zhou, B, Lu, Y, Hajifathalian, K, Bentham, J, Di Cesare, M, Danaei, G, Bixby, H, Cowan, MJ, Ali, MK, Taddei, C, Lo, W-C, Reis-Santos, B, Stevens, GA, Riley, LM, Miranda, JJ, Bjerregaard, P, Rivera, JA, Fouad, HM, Ma, G, Mbanya, JCN, McGarvey, ST, Mohan, V, Onat, A, Pilav, A, Ramachandran, A, Ben Romdhane, H, Paciorek, CJ, Bennett, JE, Ezzati, M, Abdeen, ZA, Kadir, KA, Abu-Rmeileh, NM, Acosta-Cazares, B, Adams, R, Aekplakorn, W, Aguilar-Salinas, CA, Agyemang, C, Ahmadvand, A, Al-Othman, AR, Alkerwi, A, Amouyel, P, Amuzu, A, Bo Andersen, L, Anderssen, SA, Anjana, RM, Aounallah-Skhiri, H, Aris, T, Arlappa, N, Arveiler, D, Assah, FK, Avdicová, M, Azizi, F, Balakrishna, N, Bandosz, P, Barbagallo, CM, Barceló, A, Batieha, AM, Baur, LA, Benet, M, Bernabe-Ortiz, A, Bharadwaj, S, Bhargava, SK, Bi, Y, Bjertness, E, Bjertness, MB, Björkelund, C, Blokstra, A, Bo, S, Boehm, BO, Boissonnet, CP, Bovet, P, Brajkovich, I, Breckenkamp, J, Brenner, H, Brewster, LM, Brian, GR, Bruno, G, Bugge, A, De León, AC, Can, G, C ndido, APC, Capuano, V, Carlsson, AC, Carvalho, MJ, Casanueva, FF, Casas, J-P, Caserta, CA, Castetbon, K, Chamukuttan, S, Chaturvedi, N, Chen, C-J, Chen, F, Chen, S, Cheng, C-Y, Chetrit, A, Chiou, S-T, Cho, Y, Chudek, J, Cifkova, R, Claessens, F, Concin, H, Cooper, C, Cooper, R, Costanzo, S, Cottel, D, Cowell, C, Crujeiras, AB, D Arrigo, G, Dallongeville, J, Dankner, R, Dauchet, L, De Gaetano, G, De Henauw, S, Deepa, M, Dehghan, A, Deschamps, V, Dhana, K, Di Castelnuovo, AF, Djalalinia, S, Doua, K, Drygas, W, Du, Y, Dzerve, V, Egbagbe, EE, Eggertsen, R, El Ati, J, Elosua, R, Erasmus, RT, Erem, C, Ergor, G, Eriksen, L, Escobedo-De La Pe na, J, Fall, CH, Farzadfar, F, Felix-Redondo, FJ, Ferguson, TS, Fernández-Bergés, D, Ferrari, M, Ferreccio, C, Feskens, EJM, Finn, JD, Föger, B, Foo, LH, Forslund, A-S, Francis, DK, Do Carmo Franco, M, Franco, OH, Frontera, G, Furusawa, T, Gaciong, Z, Garnett, SP, Gaspoz, J-M, Gasull, M, Gates, L, Geleijnse, JM, Ghasemian, A, Ghimire, A, Giampaoli, S, Gianfagna, F, Giovannelli, J, Giwercman, A, Gross, MG, Rivas, JPG, Gorbea, MB, Gottrand, F, Grafnetter, D, Grodzicki, T, Grøntved, A, Gruden, G, Gu, D, Guan, OP, Guerrero, R, Guessous, I, Guimaraes, AL, Gutierrez, L, Hambleton, IR, Hardy, R, Kumar, RH, Hata, J, He, J, Heidemann, C, Herrala, S, Hihtaniemi, IT, Ho, SY, Ho, SC, Hofman, A, Hormiga, CM, Horta, BL, Houti, L, Howitt, C, Htay, TT, Htet, AS, Htike, MMT, Hu, Y, Hussieni, AS, Huybrechts, I, Hwalla, N, Iacoviello, L, Iannone, AG, Ibrahim, MM, Ikeda, N, Ikram, MA, Irazola, VE, Islam, M, Iwasaki, M, Jacobs, JM, Jafar, T, Jamil, KM, Jasienska, G, Jiang, CQ, Jonas, JB, Joshi, P, Kafatos, A, Kalter-Leibovici, O, Kasaeian, A, Katz, J, Kaur, P, Kavousi, M, Keinänen-Kiukaanniemi, S, Kelishadi, R, Kengne, AP, Kersting, M, Khader, YS, Khalili, D, Khang, Y-H, Kiechl, S, Kim, J, Kolsteren, P, Korrovits, P, Kratzer, W, Kromhout, D, Kujala, UM, Kula, K, Kyobutungi, C, Laatikainen, T, Lachat, C, Laid, Y, Lam, TH, Landrove, O, Lanska, V, Lappas, G, Laxmaiah, A, Leclercq, C, Lee, J, Lehtimäki, T, Lekhraj, R, León-Mu noz, LM, Li, Y, Lim, W-Y, Lima-Costa, MF, Lin, H-H, Lin, X, Lissner, L, Lorbeer, R, Lozano, JE, Luksiene, D, Lundqvist, A, Lytsy, P, Machado-Coelho, GLL, Machi, S, Maggi, S, Magliano, DJ, Makdisse, M, Rao, KM, Manios, Y, Manzato, E, Margozzini, P, Marques-Vidal, P, Martorell, R, Masoodi, SR, Mathiesen, EB, Matsha, TE, McFarlane, SR, McLachlan, S, McNulty, BA, Mediene-Benchekor, S, Meirhaeghe, A, Menezes, AMB, Merat, S, Meshram, II, Mi, J, Miquel, JF, Mohamed, MK, Mohammad, K, Mohammadifard, N, Mohd Yusoff, MF, M ller, NC, Molnár, D, Mondo, CK, Morejon, A, Moreno, LA, Morgan, K, Moschonis, G, Mossakowska, M, Mostafa, A, Mota, J, Motta, J, Mu, TT, Muiesan, ML, Müller-Nurasyid, M, Mursu, J, Nagel, G, Náme ná, J, Nang, EEK, Nangia, VB, Navarrete-Mu noz, EM, Ndiaye, NC, Nenko, I, Nervi, F, Nguyen, ND, Nguyen, QN, Nieto-Martínez, RE, Ning, G, Ninomiya, T, Noale, M, Noto, D, Al Nsour, M, Ochoa-Avilés, AM, Oh, K, Ordunez, P, Osmond, C, Otero, JA, Owusu-Dabo, E, Pahomova, E, Palmieri, L, Panda-Jonas, S, Panza, F, Parsaeian, M, Peixoto, SV, Peltonen, M, Peters, A, Peykari, N, Pham, ST, Pitakaka, F, Piwonska, A, Piwonski, J, Plans-Rubió, P, Porta, M, Portegies, MLP, Poustchi, H, Pradeepa, R, Price, JF, Punab, M, Qasrawi, RF, Qorbani, M, Radisauskas, R, Rahman, M, Raitakari, O, Rao, SR, Ramke, J, Ramos, R, Rampal, S, Rathmann, W, Redon, J, Reganit, PFM, Rigo, F, Robinson, SM, Robitaille, C, Rodríguez-Artalejo, F, Del CristoRodriguez-Perez, M, Rodríguez-Villamizar, LA, Rojas-Martinez, R, Ronkainen, K, Rosengren, A, Rubinstein, A, Rui, O, Ruiz-Betancourt, BS, Zhou, B, Lu, Y, Hajifathalian, K, Bentham, J, Di Cesare, M, Danaei, G, Bixby, H, Cowan, MJ, Ali, MK, Taddei, C, Lo, W-C, Reis-Santos, B, Stevens, GA, Riley, LM, Miranda, JJ, Bjerregaard, P, Rivera, JA, Fouad, HM, Ma, G, Mbanya, JCN, McGarvey, ST, Mohan, V, Onat, A, Pilav, A, Ramachandran, A, Ben Romdhane, H, Paciorek, CJ, Bennett, JE, Ezzati, M, Abdeen, ZA, Kadir, KA, Abu-Rmeileh, NM, Acosta-Cazares, B, Adams, R, Aekplakorn, W, Aguilar-Salinas, CA, Agyemang, C, Ahmadvand, A, Al-Othman, AR, Alkerwi, A, Amouyel, P, Amuzu, A, Bo Andersen, L, Anderssen, SA, Anjana, RM, Aounallah-Skhiri, H, Aris, T, Arlappa, N, Arveiler, D, Assah, FK, Avdicová, M, Azizi, F, Balakrishna, N, Bandosz, P, Barbagallo, CM, Barceló, A, Batieha, AM, Baur, LA, Benet, M, Bernabe-Ortiz, A, Bharadwaj, S, Bhargava, SK, Bi, Y, Bjertness, E, Bjertness, MB, Björkelund, C, Blokstra, A, Bo, S, Boehm, BO, Boissonnet, CP, Bovet, P, Brajkovich, I, Breckenkamp, J, Brenner, H, Brewster, LM, Brian, GR, Bruno, G, Bugge, A, De León, AC, Can, G, C ndido, APC, Capuano, V, Carlsson, AC, Carvalho, MJ, Casanueva, FF, Casas, J-P, Caserta, CA, Castetbon, K, Chamukuttan, S, Chaturvedi, N, Chen, C-J, Chen, F, Chen, S, Cheng, C-Y, Chetrit, A, Chiou, S-T, Cho, Y, Chudek, J, Cifkova, R, Claessens, F, Concin, H, Cooper, C, Cooper, R, Costanzo, S, Cottel, D, Cowell, C, Crujeiras, AB, D Arrigo, G, Dallongeville, J, Dankner, R, Dauchet, L, De Gaetano, G, De Henauw, S, Deepa, M, Dehghan, A, Deschamps, V, Dhana, K, Di Castelnuovo, AF, Djalalinia, S, Doua, K, Drygas, W, Du, Y, Dzerve, V, Egbagbe, EE, Eggertsen, R, El Ati, J, Elosua, R, Erasmus, RT, Erem, C, Ergor, G, Eriksen, L, Escobedo-De La Pe na, J, Fall, CH, Farzadfar, F, Felix-Redondo, FJ, Ferguson, TS, Fernández-Bergés, D, Ferrari, M, Ferreccio, C, Feskens, EJM, Finn, JD, Föger, B, Foo, LH, Forslund, A-S, Francis, DK, Do Carmo Franco, M, Franco, OH, Frontera, G, Furusawa, T, Gaciong, Z, Garnett, SP, Gaspoz, J-M, Gasull, M, Gates, L, Geleijnse, JM, Ghasemian, A, Ghimire, A, Giampaoli, S, Gianfagna, F, Giovannelli, J, Giwercman, A, Gross, MG, Rivas, JPG, Gorbea, MB, Gottrand, F, Grafnetter, D, Grodzicki, T, Grøntved, A, Gruden, G, Gu, D, Guan, OP, Guerrero, R, Guessous, I, Guimaraes, AL, Gutierrez, L, Hambleton, IR, Hardy, R, Kumar, RH, Hata, J, He, J, Heidemann, C, Herrala, S, Hihtaniemi, IT, Ho, SY, Ho, SC, Hofman, A, Hormiga, CM, Horta, BL, Houti, L, Howitt, C, Htay, TT, Htet, AS, Htike, MMT, Hu, Y, Hussieni, AS, Huybrechts, I, Hwalla, N, Iacoviello, L, Iannone, AG, Ibrahim, MM, Ikeda, N, Ikram, MA, Irazola, VE, Islam, M, Iwasaki, M, Jacobs, JM, Jafar, T, Jamil, KM, Jasienska, G, Jiang, CQ, Jonas, JB, Joshi, P, Kafatos, A, Kalter-Leibovici, O, Kasaeian, A, Katz, J, Kaur, P, Kavousi, M, Keinänen-Kiukaanniemi, S, Kelishadi, R, Kengne, AP, Kersting, M, Khader, YS, Khalili, D, Khang, Y-H, Kiechl, S, Kim, J, Kolsteren, P, Korrovits, P, Kratzer, W, Kromhout, D, Kujala, UM, Kula, K, Kyobutungi, C, Laatikainen, T, Lachat, C, Laid, Y, Lam, TH, Landrove, O, Lanska, V, Lappas, G, Laxmaiah, A, Leclercq, C, Lee, J, Lehtimäki, T, Lekhraj, R, León-Mu noz, LM, Li, Y, Lim, W-Y, Lima-Costa, MF, Lin, H-H, Lin, X, Lissner, L, Lorbeer, R, Lozano, JE, Luksiene, D, Lundqvist, A, Lytsy, P, Machado-Coelho, GLL, Machi, S, Maggi, S, Magliano, DJ, Makdisse, M, Rao, KM, Manios, Y, Manzato, E, Margozzini, P, Marques-Vidal, P, Martorell, R, Masoodi, SR, Mathiesen, EB, Matsha, TE, McFarlane, SR, McLachlan, S, McNulty, BA, Mediene-Benchekor, S, Meirhaeghe, A, Menezes, AMB, Merat, S, Meshram, II, Mi, J, Miquel, JF, Mohamed, MK, Mohammad, K, Mohammadifard, N, Mohd Yusoff, MF, M ller, NC, Molnár, D, Mondo, CK, Morejon, A, Moreno, LA, Morgan, K, Moschonis, G, Mossakowska, M, Mostafa, A, Mota, J, Motta, J, Mu, TT, Muiesan, ML, Müller-Nurasyid, M, Mursu, J, Nagel, G, Náme ná, J, Nang, EEK, Nangia, VB, Navarrete-Mu noz, EM, Ndiaye, NC, Nenko, I, Nervi, F, Nguyen, ND, Nguyen, QN, Nieto-Martínez, RE, Ning, G, Ninomiya, T, Noale, M, Noto, D, Al Nsour, M, Ochoa-Avilés, AM, Oh, K, Ordunez, P, Osmond, C, Otero, JA, Owusu-Dabo, E, Pahomova, E, Palmieri, L, Panda-Jonas, S, Panza, F, Parsaeian, M, Peixoto, SV, Peltonen, M, Peters, A, Peykari, N, Pham, ST, Pitakaka, F, Piwonska, A, Piwonski, J, Plans-Rubió, P, Porta, M, Portegies, MLP, Poustchi, H, Pradeepa, R, Price, JF, Punab, M, Qasrawi, RF, Qorbani, M, Radisauskas, R, Rahman, M, Raitakari, O, Rao, SR, Ramke, J, Ramos, R, Rampal, S, Rathmann, W, Redon, J, Reganit, PFM, Rigo, F, Robinson, SM, Robitaille, C, Rodríguez-Artalejo, F, Del CristoRodriguez-Perez, M, Rodríguez-Villamizar, LA, Rojas-Martinez, R, Ronkainen, K, Rosengren, A, Rubinstein, A, Rui, O, and Ruiz-Betancourt, BS

Abstract

Background One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age-standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are affecting the number of adults with diabetes. Methods We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence—defined as fasting plasma glucose of 7·0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs—in 200 countries and territories in 21 regions, by sex and from 1980 to 2014. We also calculated the posterior probability of meeting the global diabetes target if post-2000 trends continue. Findings We used data from 751 studies including 4 372 000 adults from 146 of the 200 countries we make estimates for. Global age-standardised diabetes prevalence increased from 4·3% (95% credible interval 2·4–7·0) in 1980 to 9·0% (7·2–11·1) in 2014 in men, and from 5·0% (2·9–7·9) to 7·9% (6·4–9·7) in women. The number of adults with diabetes in the world increased from 108 million in 1980 to 422 million in 2014 (28·5% due to the rise in prevalence, 39·7% due to population growth and ageing, and 31·8% due to interaction of these two factors). Age-standardised adult diabetes prevalence in 2014 was lowest in northwestern Europe, and highest in Polynesia and Micronesia, at nearly 25%, followed by Melanesia and the Middle East and north Africa. Between 1980 and 2014 there was little change in age-standardised diabetes prevalence in adult women in continental western Europe, although crude prevalence rose because of ageing of the population. By contrast, age-standardised adult prevalence rose by 15 percentage points in men and women in Pol

Published
2016

5. Effects of diabetes definition on global surveillance of diabetes prevalence and diagnosis: A pooled analysis of 96 population-based studies with 331 288 participants

Author

Danaei, G, Fahimi, S, Lu, Y, Zhou, B, Hajifathalian, K, Cesare, MD, Lo, W-C, Reis-Santos, B, Cowan, MJ, Shaw, JE, Bentham, J, Lin, JK, Bixby, H, Magliano, D, Bovet, P, Miranda, JJ, Khang, Y-H, Stevens, GA, Riley, LM, Ali, MK, Ezzati, M, Abdeen, ZA, Kadir, KA, Abu-Rmeileh, NM, Acosta-Cazares, B, Aekplakorn, W, Aguilar-Salinas, CA, Ahmadvand, A, Nsour, MA, Alkerwi, A, Amouyel, P, Andersen, LB, Anderssen, SA, Andrade, DS, Anjana, RM, Aounallah-Skhiri, H, Aris, T, Arlappa, N, Arveiler, D, Assah, FK, Avdicová, M, Balakrishna, N, Bandosz, P, Barbagallo, CM, Barceló, Alberto, Batieha, AM, Baur, LA, Romdhane, HB, Bernabe-Ortiz, A, Bhargava, SK, Bi, Y, Bjerregaard, P, Björkelund, C, Blake, M, Blokstra, A, Bo, S, Boehm, BO, Boissonnet, CP, Brajkovich, I, Breckenkamp, J, Brewster, LM, Brian, GR, Bruno, G, Bugge, A, de León, AC, Can, G, Cândido, APC, Capuano, V, Carvalho, MJ, Casanueva, FF, Caserta, CA, Castetbon, K, Chamukuttan, S, Chaturvedi, N, Chen, CJ, Chen, F, Chen, S, Cheng, C-Y, Chetrit, A, Chiou, S-T, Cho, Y, Chudek, J, Cifkova, R, Claessens, F, Concin, H, Cooper, C, Cooper, R, Costanzo, S, Cottel, D, Cowell, C, Crujeiras, AB, D Arrigo, G, Dallongeville, J, Dankner, R, Dauchet, L, de Gaetano, G, de Henauw, S, Deepa, M, Dehghan, A, Dhana, K, Di Castelnuovo, AF, Djalalinia, S, Doua, K, Drygas, W, Du, Y, Egbagbe, EE, Eggertsen, R, Ati, JE, Elosua, R, Erasmus, RT, Erem, C, Ergor, G, Eriksen, L, Escobedo-de la Pe na, J, Fall, CH, Farzadfar, F, Felix-Redondo, FJ, Ferguson, TS, Fernández-Bergés, D, Ferrari, M, Ferreccio, C, Finn, JD, Föger, B, Foo, LH, Fouad, HM, Francis, DK, do Carmo Franco, M, Franco, OH, Frontera, G, Furusawa, T, Gaciong, Z, Galbarczyk, A, Garnett, SP, Gaspoz, J-M, Gasull, M, Gates, L, Geleijnse, JM, Ghasemain, A, Giampaoli, S, Gianfagna, F, Giovannelli, J, Gross, MG, González Rivas, JP, Gorbea, MB, Gottrand, F, Grant, JF, Grodzicki, T, Grøntved, A, Gruden, G, Gu, D, Guan, OP, Guerrero, R, Guessous, I, Guimaraes, AL, Gutierrez, L, Hardy, R, Kumar, RH, He, J, Heidemann, C, Hihtaniemi, IT, Ho, SY, Ho, SC, Hofman, A, Russo Horimoto, ARV, Hormiga, CM, Horta, BL, Houti, L, Hussieni, AS, Huybrechts, I, Hwalla, N, Iacoviello, L, Iannone, AG, Ibrahim, MM, Ikeda, N, Ikram, AM, Irazola, VE, Islam, M, Iwasaki, M, Jacobs, JM, Jafar, T, Jasienska, G, Jiang, CQ, Jonas, JB, Joshi, P, Kafatos, A, Kalter-Leibovici, O, Kasaeian, A, Katz, J, Kaur, P, Kavousi, M, Kelishadi, R, Kengne, AP, Kersting, M, Khader, YS, Kiechl, S, Kim, J, Kiyohara, Y, Kolsteren, P, Korrovits, P, Koskinen, S, Kratzer, W, Kromhout, D, Kula, K, Kurjata, P, Kyobutungi, C, Lachat, C, Laid, Y, Lam, TH, Landrove, O, Lanska, V, Lappas, G, Laxmaiah, A, Leclercq, C, Lee, J, Lehtimäki, T, Lekhraj, R, León-Mu noz, LM, Li, Y, Lim, W-Y, Fernanda Lima-Costa, M, Lin, H-H, Lin, X, Lissner, L, Lorbeer, R, Lozano, JE, Lundqvist, A, Lytsy, P, Ma, G, Machado-Coelho, GLL, Machi, S, Maggi, S, Makdisse, M, Rao, KM, Manios, Y, Manzato, E, Margozzini, P, Marques-Vidal, P, Martorell, R, Masoodi, SR, Matsha, TE, Mbanya, JCN, McFarlane, SR, McGarvey, ST, McLachlan, S, McNulty, BA, Mediene-Benchekor, S, Meirhaeghe, A, Menezes, AMB, Merat, S, Meshram, II, Mi, J, Miquel, JF, Mohamed, MK, Mohammad, K, Mohan, V, Yusoff, MFM, Moller, NC, Molnar, D, Mondo, CK, Moreno, LA, Morgan, K, Moschonis, G, Mossakowska, M, Mostafa, A, Mota, J, Muiesan, ML, Müller-Nurasyid, M, Mursu, J, Nagel, G, Namesna, J, Nang, EEK, Nangia, VB, Navarrete-Mu noz, EM, Ndiaye, NC, Nervi, F, Nguyen, ND, Nieto-Martínez, RE, Ning, G, Ninomiya, T, Noale, M, Noto, D, Ochoa-Avilés, AM, Oh, K, Onat, A, Osmond, C, Otero, JA, Palmieri, L, Panda-Jonas, S, Panza, F, Parsaeian, M, Peixoto, SV, Pereira, AC, Peters, A, Peykari, N, Pilav, A, Pitakaka, F, Piwonska, A, Piwonski, J, Plans-Rubió, P, Porta, M, Portegies, MLP, Poustchi, H, Pradeepa, R, Price, JF, Punab, M, Qasrawi, RF, Qorbani, M, Raitakari, O, Rao, SR, Ramachandran, A, Ramos, R, Rampal, S, Rathmann, W, Redon, J, Reganit, PFM, Rigo, F, Robinson, SM, Robitaille, C, Rodríguez, LA, Rodríguez-Artalejo, F, Rodriguez-Perez, MDC, Rojas-Martinez, R, Romaguera, D, Rosengren, A, Rubinstein, A, Rui, O, Ruiz-Betancourt, BS, Rutkowski, M, Sabanayagam, C, Sachdev, HS, Saidi, O, Sakarya, S, Salanave, B, Salonen, JT, Salvetti, M, Sánchez-Abanto, J, dos Santos, RN, Santos, R, Sardinha, LB, Scazufca, M, Schargrodsky, H, Scheidt-Nave, C, Shibuya, K, Shin, Y, Shiri, R, Siantar, R, Sibai, AM, Simon, M, Simons, J, Simons, LA, Sjostrom, M, Slowikowska-Hilczer, J, Slusarczyk, P, Smeeth, L, Snijder, MB, Solfrizzi, V, Sonestedt, E, Soumare, A, Staessen, JA, Steene-Johannessen, J, Stehle, P, Stein, AD, Stessman, J, Stöckl, D, Stokwiszewski, J, Strufaldi, MW, Sun, C-A, Sundström, J, Suriyawongpaisal, P, Sy, RG, Tai, ES, Tarawneh, M, Tarqui-Mamani, CB, Thijs, L, Tolstrup, JS, Topbas, M, Torrent, M, Traissac, P, Trinh, OTH, Tulloch-Reid, MK, Tuomainen, T-P, Turley, ML, Tzourio, C, Ueda, P, Ukoli, FM, Ulmer, H, Valdivia, G, van Valkengoed, IGM, Vanderschueren, D, Vanuzzo, D, Vega, T, Velasquez-Melendez, G, Veronesi, G, Verschuren, M, Vioque, J, Virtanen, J, Visvikis-Siest, S, Viswanathan, B, Vollenweider, P, Voutilainen, S, Wade, AN, Wagner, A, Walton, J, Mohamud, WNW, Wang, M-D, Wang, YX, Wannamethee, SG, Weerasekera, D, Whincup, PH, Widhalm, K, Wiecek, A, Wilks, RJ, Willeit, J, Wojtyniak, B, Wong, TY, Woo, J, Woodward, M, Wu, AG, Wu, FC, Wu, SL, Xu, H, Yang, X, Ye, X, Yoshihara, A, Younger-Coleman, NO, Zambon, S, Zargar, AH, Zdrojewski, T, Zhao, W, Zheng, Y, Danaei, G, Fahimi, S, Lu, Y, Zhou, B, Hajifathalian, K, Cesare, MD, Lo, W-C, Reis-Santos, B, Cowan, MJ, Shaw, JE, Bentham, J, Lin, JK, Bixby, H, Magliano, D, Bovet, P, Miranda, JJ, Khang, Y-H, Stevens, GA, Riley, LM, Ali, MK, Ezzati, M, Abdeen, ZA, Kadir, KA, Abu-Rmeileh, NM, Acosta-Cazares, B, Aekplakorn, W, Aguilar-Salinas, CA, Ahmadvand, A, Nsour, MA, Alkerwi, A, Amouyel, P, Andersen, LB, Anderssen, SA, Andrade, DS, Anjana, RM, Aounallah-Skhiri, H, Aris, T, Arlappa, N, Arveiler, D, Assah, FK, Avdicová, M, Balakrishna, N, Bandosz, P, Barbagallo, CM, Barceló, Alberto, Batieha, AM, Baur, LA, Romdhane, HB, Bernabe-Ortiz, A, Bhargava, SK, Bi, Y, Bjerregaard, P, Björkelund, C, Blake, M, Blokstra, A, Bo, S, Boehm, BO, Boissonnet, CP, Brajkovich, I, Breckenkamp, J, Brewster, LM, Brian, GR, Bruno, G, Bugge, A, de León, AC, Can, G, Cândido, APC, Capuano, V, Carvalho, MJ, Casanueva, FF, Caserta, CA, Castetbon, K, Chamukuttan, S, Chaturvedi, N, Chen, CJ, Chen, F, Chen, S, Cheng, C-Y, Chetrit, A, Chiou, S-T, Cho, Y, Chudek, J, Cifkova, R, Claessens, F, Concin, H, Cooper, C, Cooper, R, Costanzo, S, Cottel, D, Cowell, C, Crujeiras, AB, D Arrigo, G, Dallongeville, J, Dankner, R, Dauchet, L, de Gaetano, G, de Henauw, S, Deepa, M, Dehghan, A, Dhana, K, Di Castelnuovo, AF, Djalalinia, S, Doua, K, Drygas, W, Du, Y, Egbagbe, EE, Eggertsen, R, Ati, JE, Elosua, R, Erasmus, RT, Erem, C, Ergor, G, Eriksen, L, Escobedo-de la Pe na, J, Fall, CH, Farzadfar, F, Felix-Redondo, FJ, Ferguson, TS, Fernández-Bergés, D, Ferrari, M, Ferreccio, C, Finn, JD, Föger, B, Foo, LH, Fouad, HM, Francis, DK, do Carmo Franco, M, Franco, OH, Frontera, G, Furusawa, T, Gaciong, Z, Galbarczyk, A, Garnett, SP, Gaspoz, J-M, Gasull, M, Gates, L, Geleijnse, JM, Ghasemain, A, Giampaoli, S, Gianfagna, F, Giovannelli, J, Gross, MG, González Rivas, JP, Gorbea, MB, Gottrand, F, Grant, JF, Grodzicki, T, Grøntved, A, Gruden, G, Gu, D, Guan, OP, Guerrero, R, Guessous, I, Guimaraes, AL, Gutierrez, L, Hardy, R, Kumar, RH, He, J, Heidemann, C, Hihtaniemi, IT, Ho, SY, Ho, SC, Hofman, A, Russo Horimoto, ARV, Hormiga, CM, Horta, BL, Houti, L, Hussieni, AS, Huybrechts, I, Hwalla, N, Iacoviello, L, Iannone, AG, Ibrahim, MM, Ikeda, N, Ikram, AM, Irazola, VE, Islam, M, Iwasaki, M, Jacobs, JM, Jafar, T, Jasienska, G, Jiang, CQ, Jonas, JB, Joshi, P, Kafatos, A, Kalter-Leibovici, O, Kasaeian, A, Katz, J, Kaur, P, Kavousi, M, Kelishadi, R, Kengne, AP, Kersting, M, Khader, YS, Kiechl, S, Kim, J, Kiyohara, Y, Kolsteren, P, Korrovits, P, Koskinen, S, Kratzer, W, Kromhout, D, Kula, K, Kurjata, P, Kyobutungi, C, Lachat, C, Laid, Y, Lam, TH, Landrove, O, Lanska, V, Lappas, G, Laxmaiah, A, Leclercq, C, Lee, J, Lehtimäki, T, Lekhraj, R, León-Mu noz, LM, Li, Y, Lim, W-Y, Fernanda Lima-Costa, M, Lin, H-H, Lin, X, Lissner, L, Lorbeer, R, Lozano, JE, Lundqvist, A, Lytsy, P, Ma, G, Machado-Coelho, GLL, Machi, S, Maggi, S, Makdisse, M, Rao, KM, Manios, Y, Manzato, E, Margozzini, P, Marques-Vidal, P, Martorell, R, Masoodi, SR, Matsha, TE, Mbanya, JCN, McFarlane, SR, McGarvey, ST, McLachlan, S, McNulty, BA, Mediene-Benchekor, S, Meirhaeghe, A, Menezes, AMB, Merat, S, Meshram, II, Mi, J, Miquel, JF, Mohamed, MK, Mohammad, K, Mohan, V, Yusoff, MFM, Moller, NC, Molnar, D, Mondo, CK, Moreno, LA, Morgan, K, Moschonis, G, Mossakowska, M, Mostafa, A, Mota, J, Muiesan, ML, Müller-Nurasyid, M, Mursu, J, Nagel, G, Namesna, J, Nang, EEK, Nangia, VB, Navarrete-Mu noz, EM, Ndiaye, NC, Nervi, F, Nguyen, ND, Nieto-Martínez, RE, Ning, G, Ninomiya, T, Noale, M, Noto, D, Ochoa-Avilés, AM, Oh, K, Onat, A, Osmond, C, Otero, JA, Palmieri, L, Panda-Jonas, S, Panza, F, Parsaeian, M, Peixoto, SV, Pereira, AC, Peters, A, Peykari, N, Pilav, A, Pitakaka, F, Piwonska, A, Piwonski, J, Plans-Rubió, P, Porta, M, Portegies, MLP, Poustchi, H, Pradeepa, R, Price, JF, Punab, M, Qasrawi, RF, Qorbani, M, Raitakari, O, Rao, SR, Ramachandran, A, Ramos, R, Rampal, S, Rathmann, W, Redon, J, Reganit, PFM, Rigo, F, Robinson, SM, Robitaille, C, Rodríguez, LA, Rodríguez-Artalejo, F, Rodriguez-Perez, MDC, Rojas-Martinez, R, Romaguera, D, Rosengren, A, Rubinstein, A, Rui, O, Ruiz-Betancourt, BS, Rutkowski, M, Sabanayagam, C, Sachdev, HS, Saidi, O, Sakarya, S, Salanave, B, Salonen, JT, Salvetti, M, Sánchez-Abanto, J, dos Santos, RN, Santos, R, Sardinha, LB, Scazufca, M, Schargrodsky, H, Scheidt-Nave, C, Shibuya, K, Shin, Y, Shiri, R, Siantar, R, Sibai, AM, Simon, M, Simons, J, Simons, LA, Sjostrom, M, Slowikowska-Hilczer, J, Slusarczyk, P, Smeeth, L, Snijder, MB, Solfrizzi, V, Sonestedt, E, Soumare, A, Staessen, JA, Steene-Johannessen, J, Stehle, P, Stein, AD, Stessman, J, Stöckl, D, Stokwiszewski, J, Strufaldi, MW, Sun, C-A, Sundström, J, Suriyawongpaisal, P, Sy, RG, Tai, ES, Tarawneh, M, Tarqui-Mamani, CB, Thijs, L, Tolstrup, JS, Topbas, M, Torrent, M, Traissac, P, Trinh, OTH, Tulloch-Reid, MK, Tuomainen, T-P, Turley, ML, Tzourio, C, Ueda, P, Ukoli, FM, Ulmer, H, Valdivia, G, van Valkengoed, IGM, Vanderschueren, D, Vanuzzo, D, Vega, T, Velasquez-Melendez, G, Veronesi, G, Verschuren, M, Vioque, J, Virtanen, J, Visvikis-Siest, S, Viswanathan, B, Vollenweider, P, Voutilainen, S, Wade, AN, Wagner, A, Walton, J, Mohamud, WNW, Wang, M-D, Wang, YX, Wannamethee, SG, Weerasekera, D, Whincup, PH, Widhalm, K, Wiecek, A, Wilks, RJ, Willeit, J, Wojtyniak, B, Wong, TY, Woo, J, Woodward, M, Wu, AG, Wu, FC, Wu, SL, Xu, H, Yang, X, Ye, X, Yoshihara, A, Younger-Coleman, NO, Zambon, S, Zargar, AH, Zdrojewski, T, Zhao, W, and Zheng, Y

Abstract

Background Diabetes has been defined on the basis of different biomarkers, including fasting plasma glucose (FPG), 2-h plasma glucose in an oral glucose tolerance test (2hOGTT), and HbA1c. We assessed the effect of different diagnostic definitions on both the population prevalence of diabetes and the classification of previously undiagnosed individuals as having diabetes versus not having diabetes in a pooled analysis of data from population-based health examination surveys in different regions. Methods We used data from 96 population-based health examination surveys that had measured at least two of the biomarkers used for defining diabetes. Diabetes was defined using HbA1c (HbA1c ≥6·5% or history of diabetes diagnosis or using insulin or oral hypoglycaemic drugs) compared with either FPG only or FPG-or-2hOGTT definitions (FPG ≥7·0 mmol/L or 2hOGTT ≥11·1 mmol/L or history of diabetes or using insulin or oral hypoglycaemic drugs). We calculated diabetes prevalence, taking into account complex survey design and survey sample weights. We compared the prevalences of diabetes using different definitions graphically and by regression analyses. We calculated sensitivity and specificity of diabetes diagnosis based on HbA1c compared with diagnosis based on glucose among previously undiagnosed individuals (ie, excluding those with history of diabetes or using insulin or oral hypoglycaemic drugs). We calculated sensitivity and specificity in each survey, and then pooled results using a random-effects model. We assessed the sources of heterogeneity of sensitivity by meta-regressions for study characteristics selected a priori. Findings Population prevalence of diabetes based on FPG-or-2hOGTT was correlated with prevalence based on FPG alone (r=0·98), but was higher by 2–6 percentage points at different prevalence levels. Prevalence based on HbA1c was lower than prevalence based on FPG in 42·8% of age–sex–survey groups and higher in another 41·6%; in the other 15·6%, the two de

Published
2015

9. Planar structure ¼DMFCs

Author

Specchia S., Icardi U.A., Spinella C., Baglio V., D’Urso C., Stassi A., Antonucci V., Aricò A.S., and D’Arrigo G.

Published
2009

11. 3C-SiC hetero-epitaxial films for sensor fabrication

Author

Anzalone, R., Severino, A., Locke, C., Rodilosso, D., Tringali, C., Saddow, S. E., Francesco La Via, and D Arrigo, G.

Abstract

Silicon Carbide (SiC) is a very promising material for the fabrication of a new category of sensors and devices, to be used in very hostile environments (high temperature, corrosive ambient, presence of radiation, etc.). The fabrication of SiC MEMS-based sensors requires new processes able to realize microstructures on bulk material or on the SiC surface. The hetero-epitaxial growth of 3C-SiC on silicon substrates allows one to overcome the traditional limitations of SiC microfabrication. This approach puts together the standard silicon bulk microfabrication methodologies with the robust mechanical properties of 3C-SiC. Using this approach we were able to fabricate SiC cantilevers for a new class of pressure sensor. The geometries studied were selected in order to study the internal residual stress of the SiC film. X-Ray Diffraction polar figure and Bragg-Brentano scan analysis were used to check to crystal structure and the orientations of the film. SEM analysis was performed to analyze the morphology of the released MEMS structures. © 2008 Trans Tech Publications, Switzerland.

Published
2008

16. Exercise in patients on dialysis: A multicenter, randomized clinical trial (vol 28, pg 1259, 2017)

Author

Manfredini, F., Mallamaci, F., D Arrigo, G., Baggetta, R., Bolignano, D., Torino, C., Lamberti, N., Bertoli, S., Ciurlino, D., Rocca-Rey, L., Barilla, A., Battaglia, Y., Rapana, R. M., Zuccala, A., Bonanno, G., Fatuzzo, P., Rapisarda, F., Rastelli, S., Fabrizi, F., Messa, P., Paola, L., Lombardi, L., ADAMASCO CUPISTI, Fuiano, G., Lucisano, G., Summaria, C., Felisatti, M., Pozzato, E., Malagoni, A. M., Castellino, P., Aucella, F., Abd Elhafeez, S., Provenzano, P. F., Tripepi, G., Catizone, L., and Zoccali, C.

19. Synthesis and characterization of ZnS nanoparticles in water/AOT/n-heptane microemulsions

Author

Marco Rossi, Daniela Manno, V. Turco Liveri, G. D’Arrigo, G. Micocci, TURCO LIVERI, V., Rossi, M., D\'Arrigo, G., Manno, D., Micocci, Gioacchino, LIVERI TURCO, V., D'Arrigo, G., Manno, Daniela Erminia, and Micocci, G.

Subjects
Heptane, Mineralogy, Nanoparticle, General Chemistry, Micelle, chemistry.chemical_compound, chemistry, Electron diffraction, Chemical engineering, Transmission electron microscopy, General Materials Science, Microemulsion, Selected area diffraction, High-resolution transmission electron microscopy
Abstract

ZnS nanoparticles were synthetized using water-containing AOT reversed micelles as nanoreactors and characterized by UV-Vis spectrophotometry, HRTEM (high-resolution transmission electron microscopy), SAED (selected-area electron diffraction), and digital image processing. The experimental data evidence a slow growing process of fractal-like ZnS nanoparticles’ coupled with a change of their photophysical properties. Both these processes are well described by power laws. The nanoparticles size is mainly controlled by the micellar size. After evaporation of the organic solvent, it has been found that the deposit is constituted by smaller and more stable ZnS nanoparticles bathed in a surfactant matrix.

Published
1999

20. Effectiveness of ibrutinib as first-line therapy for chronic lymphocytic leukemia patients and indirect comparison with rituximab-bendamustine: Results of study on 486 cases outside clinical trials.

Author

Morabito F, Tripepi G, Del Poeta G, Mauro FR, Reda G, Sportoletti P, Laurenti L, Coscia M, Herishanu Y, Bossio S, Varettoni M, Murru R, Chiarenza A, Visentin A, Condoluci A, Moia R, Pietrasanta D, Loseto G, Consoli U, Scortechini I, Rossi FM, Zucchetto A, Al-Janazreh H, Vigna E, Martino EA, Cassin R, D Arrigo G, Galimberti S, Rago A, Angeletti I, Biagi A, Del Giudice I, Bomben R, Neri A, Fronza G, Monti P, Menichini P, Olivieri J, Cutrona G, Rossi D, Cuneo A, Di Raimondo F, Gaidano G, Polliack A, Trentin L, Foà R, Ferrarini M, Gattei V, and Gentile M

Subjects
Adenine pharmacology, Adenine therapeutic use, Aged, Bendamustine Hydrochloride pharmacology, Humans, Piperidines pharmacology, Progression-Free Survival, Rituximab pharmacology, Adenine analogs & derivatives, Bendamustine Hydrochloride therapeutic use, Leukemia, Lymphocytic, Chronic, B-Cell drug therapy, Piperidines therapeutic use, Rituximab therapeutic use
Published
2021
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21. In search of potential predictors of erythropoiesis-stimulating agents (ESAs) hyporesponsiveness: a population-based study.

Author

Ingrasciotta Y, Lacava V, Marcianò I, Giorgianni F, Tripepi G, D' Arrigo G, Chinellato A, Ugo Tari D, Santoro D, and Trifirò G

Subjects
Adult, Aged, Aged, 80 and over, Anemia epidemiology, Cohort Studies, Erythropoiesis physiology, Female, Follow-Up Studies, Forecasting, Hematinics pharmacology, Humans, Italy epidemiology, Male, Middle Aged, Neoplasms blood, Neoplasms drug therapy, Neoplasms epidemiology, Renal Insufficiency, Chronic blood, Renal Insufficiency, Chronic drug therapy, Renal Insufficiency, Chronic epidemiology, Retrospective Studies, Anemia blood, Anemia drug therapy, Erythropoiesis drug effects, Erythropoietin blood, Hematinics therapeutic use, Population Surveillance methods
Abstract

Background: Evidences show that around 20% of biosimilar or originator erythropoiesis-stimulating agents (ESAs) users are hyporesponsive. Controversial post-marketing data exist on the predictors of ESA hyporesponsiveness. The aim of this study was to identify predictors of ESA hyporesponsiveness in patients with chronic kidney disease (CKD) or cancer in clinical practice., Methods: During the years 2009-2015, a multi-center, population-based, cohort study was conducted using claims databases of Treviso and Caserta Local Health Units (LHUs). All incident ESA users were characterized at baseline and the differences between the baseline hemoglobin (Hb) value, that is the Hb registered within 30 days prior to the first ESA dispensing (index date, ID) and each outcome Hb value (registered between 30 and 180 days after ID) were calculated and defined as delta Hb (ΔHb). Incident ESA users were defined as hyporesponsive if, during follow-up, they registered at least one ΔHb < 0 g/dL. Including all potential predictors of ESA hyporesponsiveness and stratifying by indication for use, univariate and multivariate binary logistic regression models and Receiver Operating Characteristic (ROC) curves were carried out., Results: In general, 1080 incident ESA users (CKD: 57.0%; cancer: 43.0%) were identified. In CKD, predictors of ESA hyporesponsiveness were C-reactive protein (OR = 1.2, 95% CI: 1.0-1.5; P-value = 0.060) and high levels of baseline Hb (OR = 1.7, 95% CI: 1.2-2.2; P-value< 0,001), the latter being also predictor of ESA hyporesponsiveness in cancer (OR = 1.7, 95% CI: 1.1-2.4; P-value = 0.007). Both in CKD and in cancer, the type of ESA, biosimilar or originator, was not a predictor of ESA hyporesponsiveness. In CKD, concomitant use of iron preparations (OR = 0.3, 95% CI: 0.2-0.7; P-value = 0.002) and of high dosage of angiotensin-converting enzyme inhibitors/angiotensin II-receptor blockers (OR = 0.5, 95% CI: 0.3-0.9; P-value = 0.022) were protective factors against ESA hyporesponsiveness., Conclusions: The study confirmed traditional potential predictors of hyporesponsiveness to ESA. The use of biosimilar or originator ESA was not a predictor of hyporesponsiveness in an outpatient setting from two large Italian areas. A better knowledge of the predictors of ESA response would allow a better anemia management to improve patients' quality of life.

Published
2019
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22. Effect of pentoxifylline on renal outcomes in chronic kidney disease patients: A systematic review and meta-analysis.

Author

Leporini C, Pisano A, Russo E, D Arrigo G, de Sarro G, Coppolino G, and Bolignano D

Subjects
Humans, Kidney drug effects, Kidney physiology, Proteinuria physiopathology, Randomized Controlled Trials as Topic, Renal Insufficiency, Chronic physiopathology, Renal Insufficiency, Chronic urine, Pentoxifylline therapeutic use, Proteinuria drug therapy, Renal Insufficiency, Chronic drug therapy
Abstract

Chronic kidney disease (CKD) represents an important health problem worldwide and the search for new therapeutic approaches for retarding CKD progression is a timely issue. Recent evidence suggest that the anti-inflammatory and hemorrheologic drug Pentoxifylline (PTX), may produce favorable effects on kidney function. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to ascertain whether PTX derivatives, alone or in combination to other treatments, may be useful in slowing down disease progression in patients with diabetic or non-diabetic CKD. We found 26 studies (1518 subjects) matching our search criteria. Information on the effects of PTX on hard renal outcomes (doubling of serum creatinine or need for chronic dialysis) were lacking in all the reviewed trials. Conversely, PTX was effective in reducing proteinuria compared to control, a benefit that was more evident in patients with type-1 diabetes mellitus, higher proteinuria at baseline and early renal impairment. An improvement in renal function (eGFR/creatinine clearance) was observed particularly in patients with more advanced CKD stage and in studies with longer follow-up. Conversely, cumulative analyses did not reveal any evident reduction in urinary albumin excretion, even in diabetic patients. The use of PTX was relatively safe as most trials recorded only minor gastrointestinal adverse effects. Although these findings point at some reno-protective effects of PTX, there is no conclusive evidence proving the usefulness of this agent for improving renal outcomes in subjects with chronic kidney disease of various etiology. Future trials adequately powered and designed on hard clinical end-points are needed., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

Published
2016
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23. A new and safe device for minimally invasive saphenous vein harvesting: results after 100 cases.

Author

Dʼarrigo G, Mauceri G, Mudanò M, Scolaro A, Fraggetta F, Grasso G, and Lomeo A

Abstract

Purpose: : The saphenous vein is the most commonly used bypass conduit for coronary surgery. Endoscopic harvesting techniques are associated with significant reduction of wound complications but are time-consuming and expensive. The authors developed a device to perform minimally invasive harvesting of the saphenous vein-rapidly, inexpensively, and safely., Description: : Patients hospitalized for isolated CABG (n = 134) participated in the study. Each vein had been harvested through the use of our minimally invasive system., Evaluation: : The veins were harvested in 130 cases; 378 vein samples were collected for pathology study, with complete integrity of the vein as the result of the "no touch" technique with the device. This integrity could be very important for the long-term patency of the vein graft. After surgery, there were no wound dehiscences, infections, or major hematomas. There was 1 case (0.76%) of superficial hematoma and 3 cases (2.30%) of lymphoceles., Conclusions: : Although commercial disposable systems are now available to allow minimally invasive harvesting of the saphenous vein, the authors think that harvesting the greater saphenous vein with the cylinder steel device is easy to learn can be used safely and at much-reduced costs.

Published
2007
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