669 results on '"D’ORO, L"'
Search Results
2. CAROTID-FEMORAL PULSE WAVE VELOCITY PROGRESSION IN HYPERTENSIVE PATIENTS IS ASSOCIATED WITH SUBSEQUENT CV OUTCOMES
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Maloberti, A, Rebora, P, Occhino, G, Andreano, A, Intravaia, R, Tognola, C, Toscani, G, Morelli, M, Pezzoli, S, D’Oro, L, Russo, A, Giannattasio, C, Maloberti, Alessandro, Rebora, Paola, Occhino, Giuseppe, Andreano, Anita, Intravaia, Rita Cristina My, Tognola, Chiara, Toscani, Giorgio, Morelli, Martina, Pezzoli, Stefano, D’Oro, Luca Cavalieri, Russo, Antonio, Giannattasio, Cristina, Maloberti, A, Rebora, P, Occhino, G, Andreano, A, Intravaia, R, Tognola, C, Toscani, G, Morelli, M, Pezzoli, S, D’Oro, L, Russo, A, Giannattasio, C, Maloberti, Alessandro, Rebora, Paola, Occhino, Giuseppe, Andreano, Anita, Intravaia, Rita Cristina My, Tognola, Chiara, Toscani, Giorgio, Morelli, Martina, Pezzoli, Stefano, D’Oro, Luca Cavalieri, Russo, Antonio, and Giannattasio, Cristina
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- 2024
3. Long-term survival and cure fraction estimates for childhood cancer in Europe (EUROCARE-6): results from a population-based study
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Botta, L, Gatta, G, Capocaccia, R, Stiller, C, Canete, A, Dal Maso, L, Innos, K, Mihor, A, Erdmann, F, Spix, C, Lacour, B, Marcos-Gragera, R, Murray, D, Rossi, S, Hackl, M, Van Eycken, E, Van Damme, N, Valerianova, Z, Sekerija, M, Scoutellas, V, Demetriou, A, Dusek, L, Krejci, D, Storm, H, Magi, M, Paapsi, K, Malila, N, Pitkaniemi, J, Jooste, V, Clavel, J, Poulalhon, C, Desandes, E, Monnereau, A, Katalinic, A, Petridou, E, Markozannes, G, Garami, M, Birgisson, H, Walsh, P, Mazzoleni, G, Vittadello, F, Cuccaro, F, Galasso, R, Sampietro, G, Rosso, S, Gasparotto, C, Maifredi, G, Ferrante, M, Torrisi, A, Sutera Sardo, A, Gambino, M, Lanzoni, M, Ballotari, P, Giacomazzi, E, Ferretti, S, Caldarella, A, Manneschi, G, Sant, M, Baili, P, Berrino, F, Trama, A, Lillini, R, Bernasconi, A, Bonfarnuzzo, S, Vener, C, Didone, F, Lasalvia, P, Del Monego, G, Buratti, L, Serraino, D, Taborelli, M, De Angelis, R, Demuru, E, Di Benedetto, C, Santaquilani, M, Venanzi, S, Tallon, M, Boni, L, Iacovacci, S, Russo, A, Gervasi, F, Spagnoli, G, Cavalieri d'Oro, L, Fusco, M, Vitale, M, Usala, M, Vitale, F, Michiara, M, Chiranda, G, Sacerdote, C, Maule, M, Cascone, G, Spata, E, Mangone, L, Falcini, F, Cavallo, R, Piras, D, Dinaro, Y, Castaing, M, Fanetti, A, Minerba, S, Candela, G, Scuderi, T, Rizzello, R, Stracci, F, Tagliabue, G, Rugge, M, Brustolin, A, Pildava, S, Smailyte, G, Azzopardi, M, Johannesen, T, Didkowska, J, Wojciechowska, U, Bielska-Lasota, M, Pais, A, Ferreira, A, Bento, M, Miranda, A, Safaei Diba, C, Zadnik, V, Zagar, T, Sanchez-Contador Escudero, C, Franch Sureda, P, Lopez de Munain, A, De-La-Cruz, M, Rojas, M, Aleman, A, Vizcaino, A, Almela, F, Sanvisens, A, Sanchez, M, Chirlaque, M, Sanchez-Gil, A, Guevara, M, Ardanaz, E, Canete-Nieto, A, Peris-Bonet, R, Galceran, J, Carulla, M, Kuehni, C, Redmond, S, Visser, O, Karim-Kos, H, Stevens, S, Gavin, A, Morrison, D, Huws, D, Botta L., Gatta G., Capocaccia R., Stiller C., Canete A., Dal Maso L., Innos K., Mihor A., Erdmann F., Spix C., Lacour B., Marcos-Gragera R., Murray D., Rossi S., Hackl M., Van Eycken E., Van Damme N., Valerianova Z., Sekerija M., Scoutellas V., Demetriou A., Dusek L., Krejci D., Storm H., Magi M., Paapsi K., Malila N., Pitkaniemi J., Jooste V., Clavel J., Poulalhon C., Desandes E., Monnereau A., Katalinic A., Petridou E., Markozannes G., Garami M., Birgisson H., Walsh P. M., Mazzoleni G., Vittadello F., Cuccaro F., Galasso R., Sampietro G., Rosso S., Gasparotto C., Maifredi G., Ferrante M., Torrisi A., Sutera Sardo A., Gambino M. L., Lanzoni M., Ballotari P., Giacomazzi E., Ferretti S., Caldarella A., Manneschi G., Sant M., Baili P., Berrino F., Trama A., Lillini R., Bernasconi A., Bonfarnuzzo S., Vener C., Didone F., Lasalvia P., Del Monego G., Buratti L., Serraino D., Taborelli M., De Angelis R., Demuru E., Di Benedetto C., Santaquilani M., Venanzi S., Tallon M., Boni L., Iacovacci S., Russo A. G., Gervasi F., Spagnoli G., Cavalieri d'Oro L., Fusco M., Vitale M. F., Usala M., Vitale F., Michiara M., Chiranda G., Sacerdote C., Maule M., Cascone G., Spata E., Mangone L., Falcini F., Cavallo R., Piras D., Dinaro Y., Castaing M., Fanetti A. C., Minerba S., Candela G., Scuderi T., Rizzello R. V., Stracci F., Tagliabue G., Rugge M., Brustolin A., Pildava S., Smailyte G., Azzopardi M., Johannesen T. B., Didkowska J., Wojciechowska U., Bielska-Lasota M., Pais A., Ferreira A. M., Bento M. J., Miranda A., Safaei Diba C., Zadnik V., Zagar T., Sanchez-Contador Escudero C., Franch Sureda P., Lopez de Munain A., De-La-Cruz M., Rojas M. D., Aleman A., Vizcaino A., Almela F., Sanvisens A., Sanchez M. J., Chirlaque M. D., Sanchez-Gil A., Guevara M., Ardanaz E., Canete-Nieto A., Peris-Bonet R., Galceran J., Carulla M., Kuehni C., Redmond S., Visser O., Karim-Kos H., Stevens S., Gavin A., Morrison D., Huws D. W., Botta, L, Gatta, G, Capocaccia, R, Stiller, C, Canete, A, Dal Maso, L, Innos, K, Mihor, A, Erdmann, F, Spix, C, Lacour, B, Marcos-Gragera, R, Murray, D, Rossi, S, Hackl, M, Van Eycken, E, Van Damme, N, Valerianova, Z, Sekerija, M, Scoutellas, V, Demetriou, A, Dusek, L, Krejci, D, Storm, H, Magi, M, Paapsi, K, Malila, N, Pitkaniemi, J, Jooste, V, Clavel, J, Poulalhon, C, Desandes, E, Monnereau, A, Katalinic, A, Petridou, E, Markozannes, G, Garami, M, Birgisson, H, Walsh, P, Mazzoleni, G, Vittadello, F, Cuccaro, F, Galasso, R, Sampietro, G, Rosso, S, Gasparotto, C, Maifredi, G, Ferrante, M, Torrisi, A, Sutera Sardo, A, Gambino, M, Lanzoni, M, Ballotari, P, Giacomazzi, E, Ferretti, S, Caldarella, A, Manneschi, G, Sant, M, Baili, P, Berrino, F, Trama, A, Lillini, R, Bernasconi, A, Bonfarnuzzo, S, Vener, C, Didone, F, Lasalvia, P, Del Monego, G, Buratti, L, Serraino, D, Taborelli, M, De Angelis, R, Demuru, E, Di Benedetto, C, Santaquilani, M, Venanzi, S, Tallon, M, Boni, L, Iacovacci, S, Russo, A, Gervasi, F, Spagnoli, G, Cavalieri d'Oro, L, Fusco, M, Vitale, M, Usala, M, Vitale, F, Michiara, M, Chiranda, G, Sacerdote, C, Maule, M, Cascone, G, Spata, E, Mangone, L, Falcini, F, Cavallo, R, Piras, D, Dinaro, Y, Castaing, M, Fanetti, A, Minerba, S, Candela, G, Scuderi, T, Rizzello, R, Stracci, F, Tagliabue, G, Rugge, M, Brustolin, A, Pildava, S, Smailyte, G, Azzopardi, M, Johannesen, T, Didkowska, J, Wojciechowska, U, Bielska-Lasota, M, Pais, A, Ferreira, A, Bento, M, Miranda, A, Safaei Diba, C, Zadnik, V, Zagar, T, Sanchez-Contador Escudero, C, Franch Sureda, P, Lopez de Munain, A, De-La-Cruz, M, Rojas, M, Aleman, A, Vizcaino, A, Almela, F, Sanvisens, A, Sanchez, M, Chirlaque, M, Sanchez-Gil, A, Guevara, M, Ardanaz, E, Canete-Nieto, A, Peris-Bonet, R, Galceran, J, Carulla, M, Kuehni, C, Redmond, S, Visser, O, Karim-Kos, H, Stevens, S, Gavin, A, Morrison, D, Huws, D, Botta L., Gatta G., Capocaccia R., Stiller C., Canete A., Dal Maso L., Innos K., Mihor A., Erdmann F., Spix C., Lacour B., Marcos-Gragera R., Murray D., Rossi S., Hackl M., Van Eycken E., Van Damme N., Valerianova Z., Sekerija M., Scoutellas V., Demetriou A., Dusek L., Krejci D., Storm H., Magi M., Paapsi K., Malila N., Pitkaniemi J., Jooste V., Clavel J., Poulalhon C., Desandes E., Monnereau A., Katalinic A., Petridou E., Markozannes G., Garami M., Birgisson H., Walsh P. M., Mazzoleni G., Vittadello F., Cuccaro F., Galasso R., Sampietro G., Rosso S., Gasparotto C., Maifredi G., Ferrante M., Torrisi A., Sutera Sardo A., Gambino M. L., Lanzoni M., Ballotari P., Giacomazzi E., Ferretti S., Caldarella A., Manneschi G., Sant M., Baili P., Berrino F., Trama A., Lillini R., Bernasconi A., Bonfarnuzzo S., Vener C., Didone F., Lasalvia P., Del Monego G., Buratti L., Serraino D., Taborelli M., De Angelis R., Demuru E., Di Benedetto C., Santaquilani M., Venanzi S., Tallon M., Boni L., Iacovacci S., Russo A. G., Gervasi F., Spagnoli G., Cavalieri d'Oro L., Fusco M., Vitale M. F., Usala M., Vitale F., Michiara M., Chiranda G., Sacerdote C., Maule M., Cascone G., Spata E., Mangone L., Falcini F., Cavallo R., Piras D., Dinaro Y., Castaing M., Fanetti A. C., Minerba S., Candela G., Scuderi T., Rizzello R. V., Stracci F., Tagliabue G., Rugge M., Brustolin A., Pildava S., Smailyte G., Azzopardi M., Johannesen T. B., Didkowska J., Wojciechowska U., Bielska-Lasota M., Pais A., Ferreira A. M., Bento M. J., Miranda A., Safaei Diba C., Zadnik V., Zagar T., Sanchez-Contador Escudero C., Franch Sureda P., Lopez de Munain A., De-La-Cruz M., Rojas M. D., Aleman A., Vizcaino A., Almela F., Sanvisens A., Sanchez M. J., Chirlaque M. D., Sanchez-Gil A., Guevara M., Ardanaz E., Canete-Nieto A., Peris-Bonet R., Galceran J., Carulla M., Kuehni C., Redmond S., Visser O., Karim-Kos H., Stevens S., Gavin A., Morrison D., and Huws D. W.
- Abstract
Background: The EUROCARE-5 study revealed disparities in childhood cancer survival among European countries, giving rise to important initiatives across Europe to reduce the gap. Extending its representativeness through increased coverage of eastern European countries, the EUROCARE-6 study aimed to update survival progress across countries and years of diagnosis and provide new analytical perspectives on estimates of long-term survival and the cured fraction of patients with childhood cancer. Methods: In this population-based study, we analysed 135 847 children (aged 0–14 years) diagnosed during 2000–13 and followed up to the end of 2014, recruited from 80 population-based cancer registries in 31 European countries. We calculated age-adjusted 5-year survival differences by country and over time using period analysis, for all cancers combined and for major cancer types. We applied a variant of standard mixture cure models for survival data to estimate the cure fraction of patients by childhood cancer and to estimate projected 15-year survival. Findings: 5-year survival for all childhood cancer combined in Europe in 2010–14 was 81% (95% CI 81–82), showing an increase of three percentage points compared with 2004–06. Significant progress over time was observed for almost all cancers. Survival remained stable for osteosarcomas, Ewing sarcoma, Burkitt lymphoma, non-Hodgkin lymphomas, and rhabdomyoscarcomas. For all cancers combined, inequalities still persisted among European countries (with age-adjusted 5-year survival ranging from 71% [95% CI 60–79] to 87% [77–93]). The 15-year survival projection for all patients with childhood cancer diagnosed in 2010–13 was 78%. We estimated the yearly long-term mortality rate due to causes other than the diagnosed cancer to be around 2 per 1000 patients for all childhood cancer combined, but to approach zero for retinoblastoma. The cure fraction for patients with childhood cancer increased over time from 74% (95% CI 73–75) in 1998–
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- 2022
4. The Impact of COVID-19 Confinement on Tinnitus and Hearing Loss in Older Adults: Data From the LOST in Lombardia Study
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Jarach, C, Lugo, A, Stival, C, Bosetti, C, Amerio, A, Cavalieri d'Oro, L, Iacoviello, L, Odone, A, Stuckler, D, Zucchi, A, van den Brandt, P, Garavello, W, Cederroth, C, Schlee, W, Gallus, S, Jarach C. M., Lugo A., Stival C., Bosetti C., Amerio A., Cavalieri d'Oro L., Iacoviello L., Odone A., Stuckler D., Zucchi A., van den Brandt P., Garavello W., Cederroth C. R., Schlee W., Gallus S., Jarach, C, Lugo, A, Stival, C, Bosetti, C, Amerio, A, Cavalieri d'Oro, L, Iacoviello, L, Odone, A, Stuckler, D, Zucchi, A, van den Brandt, P, Garavello, W, Cederroth, C, Schlee, W, Gallus, S, Jarach C. M., Lugo A., Stival C., Bosetti C., Amerio A., Cavalieri d'Oro L., Iacoviello L., Odone A., Stuckler D., Zucchi A., van den Brandt P., Garavello W., Cederroth C. R., Schlee W., and Gallus S.
- Abstract
Background: Although a direct relationship between tinnitus or hearing difficulties and COVID-19 has been suggested, current literature provides inconsistent results, and no research has been undertaken in older adults. Methods: In November 2020, we conducted the LOST in Lombardia survey, a telephone-based cross-sectional study on a sample of 4,400 individuals representative of the general population aged ≥65 years from Lombardy region, Northern Italy. Individuals with diagnosed tinnitus and/or hearing loss were asked whether their conditions had improved or deteriorated in 2020 compared to 2019. Results: Overall, 8.1% of older adults reported a diagnosis of tinnitus and 10.5% of hearing loss. In 2020 compared to 2019, among individuals with tinnitus, those with increasing severity (5.0%) were similar to those decreasing it (5.3%). Among individuals with hearing loss, more people reported an increase (13.6%) than a decrease (3.2%) in their disease severity. No individual with a diagnosis in 2020 of tinnitus (n = 6) or hearing loss (n = 13) had COVID-19. The incidence of tinnitus was lower in 2020 (rate: 14.8 per 10,000 person-years) than in previous years (rate in 1990–2019: 36.0 per 10,000 person-years; p = 0.026). There was no change in the incidence of hearing loss (p = 0.134). Conclusions: In this large representative sample of older adults, on average neither COVID-19 confinement nor SARS-CoV-2 infection appeared to increase the severity or incidence of tinnitus. The increased severity of hearing difficulties may totally or partially be explained by physiologic deterioration of the condition, or by a misperception due to the use of face-masks.
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- 2022
5. Assessing determinants of SARS-CoV-2 infection in a large older adult representative sample
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Mosconi, G, primary, Stival, C, additional, Signorelli, C, additional, Amerio, A, additional, Cavalieri d'Oro, L, additional, Iacoviello, L, additional, Stuckler, D, additional, Zucchi, A, additional, Odone, A, additional, and Gallus, S, additional
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- 2022
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6. Healthcare services access during the COVID-19 pandemic among older people
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Bertuccio, P, primary, Vigezzi, GP, additional, Signorelli, C, additional, Zucchi, A, additional, Cavalieri d'Oro, L, additional, Stuckler, D, additional, Iacoviello, L, additional, Gallus, S, additional, and Odone, A, additional
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- 2022
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7. COVID-19 pandemic impact on people with diabetes: results from a large representative sample of Italian older adults
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Vigezzi, Giacomo Pietro, primary, Bertuccio, Paola, additional, Bossi, Camilla Bonfadini, additional, Amerio, Andrea, additional, d’Oro, Luca Cavalieri, additional, Derosa, Giuseppe, additional, Iacoviello, Licia, additional, Stuckler, David, additional, Zucchi, Alberto, additional, Lugo, Alessandra, additional, Gallus, Silvano, additional, Odone, Anna, additional, Amerio, A., additional, Amore, M., additional, Bertuccio, P., additional, Bonaccio, M., additional, Bosetti, C., additional, Cavalieri d’Oro, L., additional, Ciampichini, R., additional, De Sena, R., additional, Gallus, S., additional, Gianfagna, F., additional, Ghislandi, S., additional, Ghulam, A., additional, Iacoviello, L., additional, Jarach, CM., additional, Lugo, A., additional, Mosconi, G., additional, Odone, A., additional, Rognoni, M., additional, Serafini, G., additional, Scala, M., additional, Signorelli, C., additional, Stival, C., additional, Stuckler, D., additional, Vigezzi, GP., additional, Wang, Y., additional, and Zucchi, A., additional
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- 2022
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8. Gender and socioeconomic inequalities in changes in a Mediterranean lifestyle among elderly Italians
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Bonaccio, M, primary, Gianfagna, F, additional, Stival, C, additional, Amerio, A, additional, Bosetti, C, additional, Cavalieri d'Oro, L, additional, Odone, A, additional, Zucchi, A, additional, Gallus, S, additional, and Iacoviello, L, additional
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- 2022
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9. COVID-19 impact on hospitalizations in older adults with chronic conditions: a real-world analysis from Lombardy, Italy
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Bosetti, C, primary, Rognoni, M, additional, Ciampichini, R, additional, Scala, M, additional, Cavalieri d'Oro, L, additional, Zucchi, A, additional, Amerio, A, additional, Iacoviello, L, additional, Odone, A, additional, and Gallus, S, additional
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- 2022
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10. It never rains but it pours: COVID-19 pandemic impact on mental health in older adults
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Amerio, A, primary, Stival, C, additional, Lugo, A, additional, Fanucchi, T, additional, Cavalieri d'Oro, L, additional, Iacoviello, L, additional, Odone, A, additional, Zucchi, A, additional, Gallus, S, additional, and Serafini, G, additional
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- 2022
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11. Clear Improvement in Real-World Chronic Myeloid Leukemia Survival: A Comparison With Randomized Controlled Trials
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Vener, C., Rossi, S., Minicozzi, P., Marcos-Gragera, R., Poirel, H. A., Maynadie, M., Troussard, X., Pravettoni, G., De Angelis, R., Sant, M., Hackl, M., Van Eycken, E., Valerianova, Z., Sekerija, M., Pavlou, P., Dusek, L., Storm, H., Magi, M., Innos, K., Malila, N., Pitkaniemi, J., Velten, M., Bouvier, A. M., Jooste, V., Guizard, A. V., Launoy, G., Yonli, S. D., Woronoff, A. S., Nousbaum, J. B., Coureau, G., Monnereau, A., Baldi, I., Hammas, K., Tretarre, B., Colonna, M., Plouvier, S., D'Almeida, T., Molinie, F., Cowppli-Bony, A., Bara, S., Schvartz, C., Defossez, G., Lapotre-Ledoux, B., Grosclaude, P., Luttmann, S., Stabenow, R., Nennecke, A., Kieschke, J., Zeissig, S., Holleczek, B., Katalinic, A., Birgisson, H., Murray, D., Walsh, P. M., Mazzoleni, G., Vittadello, F., Cuccaro, F., Galasso, R., Sampietro, G., Rosso, S., Magoni, M., Ferrante, M., Sardo, A. S., Gambino, M. L., Ballotari, P., Giacomazzi, E., Ferretti, S., Caldarella, A., Manneschi, G., Gatta, G., Baili, P., Berrino, F., Botta, L., Trama, A., Lillini, R., Bernasconi, A., Bonfarnuzzo, S., Didone, F., Lasalvia, P., Del Monego, G., Magri, M. C., Buratti, L., Serraino, D., Dal Maso, L., Capocaccia, R., Demuru, E., Di Benedetto, C., Santaquilani, M., Venanzi, S., Filiberti, R. A., Iacovacci, S., Gennaro, V., Russo, A. G., Spagnoli, G., D'Oro, L. C., Fusco, M., Vitale, M. F., Usala, M., Vitale, F., Michiara, M., Chiranda, G., Cascone, G., Spata, E., Mangone, L., Falcini, F., Cavallo, R., Piras, D., Madeddu, A., Bella, F., Fanetti, A. C., Minerba, S., Candela, G., Scuderi, T., Rizzello, R. V., Stracci, F., Tagliabue, G., Rugge, M., Brustolin, A., Pildava, S., Smailyte, G., Azzopardi, M., Johannesen, T. B., Didkowska, J., Wojciechowska, U., Bielska-Lasota, M., Pais, A., Pontes, J. L., Miranda, A., Diba, C. S., Zadnik, V., Zagar, T., Escudero, C. S. -C., Sureda, P. F., de Munain, A. L., De-La-cruz, M., Rojas, M. D., Aleman, A., Vizcaino, A., Sanchez, M. J., Chirlaque, M. D., Eslava, M. G., Ardanaz, E., Galceran, J., Carulla, M., Bergeron, Y., Bouchardy, C., Mousavi, S. M., Bordoni, A., Visser, O., Rashbass, J., Gavin, A., Morrison, D., and Huws, D. W.
- Subjects
Cancer Research ,Survival ,real-world data ,randomized controlled trials (RCTs) ,tyrosine kinase inhibitor (TKI) ,population-based studies ,Tyrosine kinase inhibitor (TKI) ,Randomized controlled trials (RCTs) ,survival ,Real-world data ,Europe ,Oncology ,cancer registries ,chronic myeloid leukemia (CML) ,Chronic myeloid leukemia (CML) ,Cancer registries ,Population-based studies - Abstract
This study was funded by the Compagnia di San Paolo, the Cariplo Foundation and the European Commission (grant number 801520 HP-JA-2017, Innovative Partnership for Action Against Cancer, iPAAC Joint Action). The sources of the funding played no role in designing the study, collecting, analyzing, or interpreting the data, writing the report, or deciding whether or not to submit the article for publication. This research was (partially) funded by Italian Ministry of Health "Ricerca Corrente" funds. Tyrosine kinase inhibitors (TKIs) have been improving the prognosis of patients with chronic myeloid leukemia (CML), but there are still large differences in survival among European countries. This raises questions on the added value of results from population-based studies, which use real-world data, compared to results of randomized controlled trials (RCTs) involving patients with CML. There are also questions about the extent of the findings on RCTs effectiveness for patients in the general population. We compare survival data extracted from our previous systematic review and meta-analysis of CML RCTs with the latest updated population-based survival data of EUROCARE-6, the widest collaborative study on cancer survival in Europe. The EUROCARE-6 CML survival estimated in patients (15-64 years) diagnosed in 2000-2006 vs. 2007-2013 revealed that the prognostic improvement highlighted by RCTs was confirmed in real-world settings, too. The study shows, evaluating for the first time all European regions, that the optimal outcome figures obtained in controlled settings for CML are also achievable (and indeed achieved) in real-world settings with prompt introduction of TKIs in daily clinical practice. However, some differences still persist, particularly in Eastern European countries, where overall survival values are lower than elsewhere, probably due to a delayed introduction of TKIs. Our results suggest an insufficient adoption of adequate protocols in daily clinical practice in those countries where CML survival values remain lower in real life than the values obtained in RCTs. New high-resolution population-based studies may help to identify failures in the clinical pathways followed there.
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- 2022
12. Predictors of medium- and long-term mortality in elderly patients with acute pulmonary embolism
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Polo Friz, H, Orenti, A, Gelfi, E, Motto, E, Primitz, L, Cavalieri d'Oro, L, Giannattasio, C, Vighi, G, Cimminiello, C, Boracchi, P, Polo Friz H., Orenti A., Gelfi E., Motto E., Primitz L., Cavalieri d'Oro L., Giannattasio C., Vighi G., Cimminiello C., Boracchi P., Polo Friz, H, Orenti, A, Gelfi, E, Motto, E, Primitz, L, Cavalieri d'Oro, L, Giannattasio, C, Vighi, G, Cimminiello, C, Boracchi, P, Polo Friz H., Orenti A., Gelfi E., Motto E., Primitz L., Cavalieri d'Oro L., Giannattasio C., Vighi G., Cimminiello C., and Boracchi P.
- Abstract
Introduction: Data on medium- and long-term prognostic factors for death in elderly patients with acute Pulmonary Embolism (APE) are lacking. The present study aimed to assess sPESI score and the Charlson Comorbidity Index (CCI) as medium- and long-term predictors of mortality in elderly patients with haemodinamically stable APE. Methods: All consecutive patients aged≥65 years old, evaluated at the emergency department (ED) of our hospital from 2010 through 2014, with a final diagnosis of APE, were included in this retrospective cohort study. Results: Study population:162 patients, female:36.5%, median age:79 years old, 74% presented a sPESI score>0, and 61% a CCI≥ 1. All causes mortality: 19.8%, 23.5%, 26.5%, 32.1% and 48.2% at 3, 6 months, 1, 2 and 5 years after APE. Univariate regression analysis: CCI≥1 was associated with a higher mortality at 3, 6 months, 1, 2 and 5 years. Multivariate Cox analysis: CCI≥1 associated with increased mortality at 3 months (HR:4.29; IC95%:1.46–12.59), 6 months (HR:5.33; IC95%:1.84–15.44), 1 year (HR:4.87; IC95%:1.87–12.70), 2 years (HR:3.78; IC95%:1.74–8.25), and 5 years (HR:2.30; IC95%:1.33–3.99). sPESI score≥1 was not found to be related to an increased medium-or long-term mortality. Negative predictive values (IC95%) of CCI≥1 were 93.65% (87.61–99.69), 93.65% (87.61–99.69), 92.06% (85.37–98.76), 87.3% (79.05–95.55) and 71.61% (60.13–83.1) for mortality at 3, 6 months, 1, 2 and 5 years. Conclusion: In elderly patients with a confirmed normotensive APE, unlike sPESI score, CCI showed to be an independent prognostic factor for medium- and long-term mortality. In these patients, after the acute phase following a PE event, the assessment of the comorbidities burden represents the most appropriate approach for predicting medium- and long-term mortality.
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- 2020
13. Prevalence, clinical correlates, and burden of undiagnosed aortic stenosis in older patients: a prospective study in a non-cardiologic acute hospital ward
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Perego, S, Zambon, A, Nistri, S, Bruni, A, Motta, S, Cavalieri D'Oro, L, Rossi, E, Annoni, G, Bellelli, G, Perego S., Zambon A., Nistri S., Bruni A., Motta S., Cavalieri D'Oro L., Rossi E., Annoni G., Bellelli G., Perego, S, Zambon, A, Nistri, S, Bruni, A, Motta, S, Cavalieri D'Oro, L, Rossi, E, Annoni, G, Bellelli, G, Perego S., Zambon A., Nistri S., Bruni A., Motta S., Cavalieri D'Oro L., Rossi E., Annoni G., and Bellelli G.
- Abstract
Background: The epidemiology of aortic stenosis (AS) in older patients admitted to non-cardiologic acute hospital wards and the effect of AS on mid-term survival are incompletely reported. In a cohort of very old patients admitted to an acute geriatric unit (AGU), we aimed to assess: (1) the prevalence of newly and previously diagnosed AS; and (2) the association between AS severity and patients’ 6-month mortality. Methods: The patients consecutively admitted in two AGU rooms from February 2016 to February 2018 were assessed with echocardiography and AS severity was defined according to standard criteria. We assessed frailty using a 34-item Frailty Index (34-FI), which was operationalized using health variable information, and the Clinical Frailty Scale (CFS). Vital status at 6 months was extracted from Regional Register of Birth and Death. Results: Two hundred and three patients (mean age 84.5 ± 6.0 SD, female gender 56.1%) were included. Of these, 57 (28.1%) had AS, mild in 9 (4.5%), moderate in 32 (16.1%) and severe in 16 (8.1%). A new diagnosis of AS was obtained in 42 (73.7%) patients, of whom 33 (78.6%) had moderate or severe AS. At 6 months, 61 (28.9%) patients died. In multiple regression models, after adjusting for covariates, frailty, as assessed with both FI and CFS, was independent predictor of 6-month mortality whereas AS was not. Conclusions: Among older patients admitted to non-cardiologic acute hospital wards, AS was common and frequently underdiagnosed. The severity of AS was not associated with increased 6-month mortality, whereas frailty was the most important predictor.
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- 2020
14. Excess risk of subsequent malignant neoplasms in adolescent and young adult cancer survivors: Results from the first Italian population-based cohort
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Trama, A, Tittarelli, A, Barigelletti, G, Botta, L, Gatta, G, Tagliabue, G, Contiero, P, Guzzinati, S, Andreano, A, Manneschi, G, Falcini, F, Castaing, M, Filiberti, R, Gasparotti, C, Cirilli, C, Mazzucco, W, Mangone, L, Iacovacci, S, Vitale, M, Stracci, F, Piffer, S, Tumino, R, Carone, S, Sampietro, G, Melcarne, A, Ballotari, P, Boschetti, L, Pisani, S, Cavalieri D'Oro, L, Cuccaro, F, D'Argenzio, A, D'Orsi, G, Fanetti, A, Ardizzone, A, Candela, G, Savoia, F, Pascucci, C, Castelli, M, Storchi, C, Bernasconi, A, Trama, Annalisa, Tittarelli, Andrea, Barigelletti, Giulio, Botta, Laura, Gatta, Gemma, Tagliabue, Giovanna, Contiero, Paolo, Guzzinati, Stefano, Andreano, Anita, Manneschi, Gianfranco, Falcini, Fabio, Castaing, Marine, Filiberti, Rosa A, Gasparotti, Cinzia, Cirilli, Claudia, Mazzucco, Walter, Mangone, Lucia, Iacovacci, Silvia, Vitale, Maria F, Stracci, Fabrizio, Piffer, Silvano, Tumino, Rosario, Carone, Simona, Sampietro, Giuseppe, Melcarne, Anna, Ballotari, Paola, Boschetti, Lorenza, Pisani, Salvatore, Cavalieri D'Oro, Luca, Cuccaro, Francesco, D'Argenzio, Angelo, D'Orsi, Giancarlo, Fanetti, Anna C, Ardizzone, Antonino, Candela, Giuseppa, Savoia, Fabio, Pascucci, Cristiana, Castelli, Maurizio, Storchi, Cinzia, Bernasconi, Alice, Trama, A, Tittarelli, A, Barigelletti, G, Botta, L, Gatta, G, Tagliabue, G, Contiero, P, Guzzinati, S, Andreano, A, Manneschi, G, Falcini, F, Castaing, M, Filiberti, R, Gasparotti, C, Cirilli, C, Mazzucco, W, Mangone, L, Iacovacci, S, Vitale, M, Stracci, F, Piffer, S, Tumino, R, Carone, S, Sampietro, G, Melcarne, A, Ballotari, P, Boschetti, L, Pisani, S, Cavalieri D'Oro, L, Cuccaro, F, D'Argenzio, A, D'Orsi, G, Fanetti, A, Ardizzone, A, Candela, G, Savoia, F, Pascucci, C, Castelli, M, Storchi, C, Bernasconi, A, Trama, Annalisa, Tittarelli, Andrea, Barigelletti, Giulio, Botta, Laura, Gatta, Gemma, Tagliabue, Giovanna, Contiero, Paolo, Guzzinati, Stefano, Andreano, Anita, Manneschi, Gianfranco, Falcini, Fabio, Castaing, Marine, Filiberti, Rosa A, Gasparotti, Cinzia, Cirilli, Claudia, Mazzucco, Walter, Mangone, Lucia, Iacovacci, Silvia, Vitale, Maria F, Stracci, Fabrizio, Piffer, Silvano, Tumino, Rosario, Carone, Simona, Sampietro, Giuseppe, Melcarne, Anna, Ballotari, Paola, Boschetti, Lorenza, Pisani, Salvatore, Cavalieri D'Oro, Luca, Cuccaro, Francesco, D'Argenzio, Angelo, D'Orsi, Giancarlo, Fanetti, Anna C, Ardizzone, Antonino, Candela, Giuseppa, Savoia, Fabio, Pascucci, Cristiana, Castelli, Maurizio, Storchi, Cinzia, and Bernasconi, Alice
- Abstract
Background: Evidence about late effects in adolescent and young adult (AYA) cancer survivors is scarce. This study assessed the risk of subsequent malignant neoplasms (SMNs) to identify the most common SMNs to be considered in follow-up care. Methods: Population-based cancer registries retrospectively identified first primary tumors (between 1976 and 2013) and SMNs in AYAs (15-39 years old at their cancer diagnosis). AYA cancer survivors were those alive at least 5 years after their first cancer diagnosis. The excess risk of SMNs was measured as standardized incidence ratios (SIRs) and absolute excess risk together with the cumulative incidence of SMNs. Results: The cohort included 67,692 AYA cancer survivors. The excess risk of developing any SMN (SIR, 1.6; 95% confidence interval, 1.5-1.7) was 60%. The excess risk of SMNs was significantly high for survivors of lymphomas; cancers of the breast, thyroid, female genital tract, digestive organs, gonads, and urinary tract; and melanomas. The cumulative incidence of all SMNs in AYA cancer survivors within 25 years of their first cancer diagnosis was approximately 10%. Subsequent tumors contributing to approximately 60% of all SMNs were breast cancer, colorectal cancer, corpus uteri cancer, and ovarian cancer in females and colorectal cancer, bladder cancer, prostate cancer, lung cancer, and lymphomas in males. Conclusions: These results highlight the need to personalize follow-up strategies for AYA cancer survivors.
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- 2022
15. Assessing the mortality risk in older patients hospitalized with a diagnosis of sepsis: the role of frailty and acute organ dysfunction
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Patrizio, E, Zambon, A, Mazzola, P, Massariello, F, Galeazzi, M, Cavalieri d’Oro, L, Bonfanti, P, Bellelli, G, Patrizio, Enrica, Zambon, Antonella, Mazzola, Paolo, Massariello, Francesca, Galeazzi, Marianna, Cavalieri d’Oro, Luca, Bonfanti, Paolo, Bellelli, Giuseppe, Patrizio, E, Zambon, A, Mazzola, P, Massariello, F, Galeazzi, M, Cavalieri d’Oro, L, Bonfanti, P, Bellelli, G, Patrizio, Enrica, Zambon, Antonella, Mazzola, Paolo, Massariello, Francesca, Galeazzi, Marianna, Cavalieri d’Oro, Luca, Bonfanti, Paolo, and Bellelli, Giuseppe
- Abstract
Background: A prognostic stratification of mortality risk in older patients with sepsis admitted to medical wards is often challenging. Aims: To evaluate the ability of the Sequential Organ Failure Assessment (SOFA) score, serum biomarkers (lactate and C-Reactive Protein, CRP), and measures of comorbidity and frailty in predicting in-hospital and 6-month mortality in a cohort of older patients admitted to an Acute Geriatric Unit (AGU) with a diagnosis of sepsis. Methods: All patients aged 70 years and over consecutively admitted to our AGU with sepsis in the study period were included. At admission, a Comprehensive Geriatric Assessment including two measures of frailty (Clinical Frailty Scale [CFS], Frailty Index [FI]) was obtained. To assess the predictivity of candidate prognostic markers, the Area Under the Receiver-Operating Characteristic (AUROC) curves were analyzed. A multivariate logistic regression analysis was also performed. Results: We included 240 patients (median age = 85, IQR = 80–89, 40.8% women), of whom 33.8% died before discharge, and 60.4% at 6 months. The SOFA score (AUROC = 0.678, 95% CI 0.610–0.747) and CRP serum levels (AUROC = 0.606, 95% CI 0.532–0.680) were good predictors of in-hospital mortality. The CFS (AUROC = 0.703, 95% CI 0.637–0.768) and the FI (AUROC = 0.677, 95% CI 0.607–0.746) better predicted 6-month mortality. Results of the regression analysis confirmed the findings of the AUROC study. The combined assessment of SOFA and measures of frailty improved the performance of the model both in the short and the long term. Conclusions: Both the severity of organ dysfunction and frailty scores should be addressed on AGU admission to establish the short- and long-term outcomes of older patients with sepsis.
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- 2022
16. Synthetic indicator of the impact of colorectal cancer screening programmes on incidence rates
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Zorzi M., Zappa M., Mazzoleni G., Morrone G., Caputo E., Galasso R., Citarella A., Sampietro G., Magoni M., Cavalieri D'Oro L., Ardizzone A., D'Argenzio A., Sciacca S., Pisani S., Ricci P., Giorno A., Ferretti S., Palma F., Serraino D., Iacovacci S., Quarta F., Filiberti R. A., Vitarelli S., Russo A. G., Carrozzi G., D'Orsi G., Fusco M., Sini G. M., Vitale F., Michiara M., Boschetti L., Chiaranda G., Rosso S., Tumino R., Mangone L., Valenti Clemente S., Falcini F., Caiazzo A. L., Cesaraccio R., Madeddu A., Fanetti A. C., Minerba S., Caldarella A., Candela G., Piffer S., Stracci F., Tagliabue G., Rugge M., Brustolin A., Castelli M., Zorzi M., Zappa M., Mazzoleni G., Morrone G., Caputo E., Galasso R., Citarella A., Sampietro G., Magoni M., Cavalieri D'Oro L., Ardizzone A., D'Argenzio A., Sciacca S., Pisani S., Ricci P., Giorno A., Ferretti S., Palma F., Serraino D., Iacovacci S., Quarta F., Filiberti R.A., Vitarelli S., Russo A.G., Carrozzi G., D'Orsi G., Fusco M., Sini G.M., Vitale F., Michiara M., Boschetti L., Chiaranda G., Rosso S., Tumino R., Mangone L., Valenti Clemente S., Falcini F., Caiazzo A.L., Cesaraccio R., Madeddu A., Fanetti A.C., Minerba S., Caldarella A., Candela G., Piffer S., Stracci F., Tagliabue G., Rugge M., Brustolin A., and Castelli M.
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Adenoma ,Male ,Colorectal cancer ,colorectal cancer ,Target population ,colorectal cancer screening ,NO ,Screening programme ,Single indicator ,medicine ,Humans ,Mass Screening ,National level ,Early Detection of Cancer ,Aged ,Potential impact ,business.industry ,Incidence ,Incidence (epidemiology) ,Gastroenterology ,Colonoscopy ,Colorectal Neoplasms ,Female ,Italy ,Middle Aged ,Occult Blood ,Patient Compliance ,Program Evaluation ,medicine.disease ,Colorectal cancer screening ,business ,Demography - Abstract
ObjectiveThe impact of a screening programme on colorectal cancer (CRC) incidence in its target population depends on several variables, including coverage with invitations, participation rate, positivity rate of the screening test, compliance with an invitation to second-level assessment and endoscopists’ sensitivity. We propose a synthetic indicator that may account for all the variables influencing the potential impact of a screening programme on CRC incidence.DesignWe defined the ‘rate of advanced adenoma on the target population’ (AA-TAP) as the rate of patients who received a diagnosis of advanced adenoma within a screening programme, divided by the programme target population. We computed the AA-TAP for the CRC Italian screening programmes (biennial faecal immunochemical test, target population 50–69 year olds) using the data of the Italian National Survey from 2003 to 2016, overall and by region, and assessed the association between AA-TAP and CRC incidence fitting a linear regression between the trend of regional CRC incidence rates in 50–74 year old subjects and the cumulative AA-TAP.ResultsIn 2016, the AA-TAP at a national level was 105×100 000, whereas significant differences were observed between the northern and central regions (respectively 126 and 149×100 000) and the South and Islands (36×100 000). The cumulative AA-TAP from 2004 to 2012 was significantly correlated with the difference between CRC incidence rates in 2013–2014 and those in 2003–2004 (p=0.009).ConclusionThe AA-TAP summarises into a single indicator the potential impact of a screening programme in reducing CRC incidence rates.
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- 2019
17. Evaluation of damage induced by Kwkt and Pikt zymocins against Brettanomyces/Dekkera spoilage yeast, as compared to sulphur dioxide
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Oro, L., Ciani, M., Bizzaro, D., and Comitini, F.
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- 2016
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18. Generation and validation of algorithms to identify subjects with dementia using administrative data
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Difrancesco, J, Pina, A, Giussani, G, Cortesi, L, Bianchi, E, Cavalieri d'Oro, L, Amodio, E, Nobili, A, Tremolizzo, L, Isella, V, Appollonio, I, Ferrarese, C, Beghi, E, DiFrancesco J. C., PINA, ALESSANDRA, Giussani G., Cortesi L., Bianchi E., Cavalieri d'Oro L., Amodio E., Nobili A., Tremolizzo L., Isella V., Appollonio I., Ferrarese C., Beghi E., Difrancesco, J, Pina, A, Giussani, G, Cortesi, L, Bianchi, E, Cavalieri d'Oro, L, Amodio, E, Nobili, A, Tremolizzo, L, Isella, V, Appollonio, I, Ferrarese, C, Beghi, E, DiFrancesco J. C., PINA, ALESSANDRA, Giussani G., Cortesi L., Bianchi E., Cavalieri d'Oro L., Amodio E., Nobili A., Tremolizzo L., Isella V., Appollonio I., Ferrarese C., and Beghi E.
- Abstract
Objectives: To generate and validate algorithms for the identification of individuals with dementia in the community setting, by the interrogation of administrative records, an inexpensive and already available source of data. Methods: We collected and anonymized information on demented individuals 65 years of age or older from ten general practitioners (GPs) in the district of Brianza (Northern Italy) and compared this with the administrative data of the local health protection agency (Agenzia per la Tutela della Salute). Indicators of the disease in the administrative database (diagnosis of dementia in the hospital discharge records; use of cholinesterase inhibitors/memantine; neuropsychological tests; brain CT/MRI; outpatient neurological visits) were used separately and in different combinations to generate algorithms for the detection of patients with dementia. Results: When used individually, indicators of dementia showed good specificity, but low sensitivity. By their combination, we generated different algorithms: I-therapy with ChEI/memantine or diagnosis of dementia at discharge or neuropsychological tests (specificity 97.9%, sensitivity 52.5%); II-therapy with ChEI/memantine or diagnosis of dementia at discharge or neuropsychological tests or brain CT/MRI or neurological visit (sensitivity 90.8%, specificity 70.6%); III-therapy with ChEI/memantine or diagnosis of dementia at discharge or neuropsychological tests or brain CT/MRIMRI and neurological visit (specificity 89.3%, sensitivity 73.3%). Conclusions: These results show that algorithms obtained from administrative data are not sufficiently accurate in classifying patients with dementia, whichever combination of variables is used for the identification of the disease. Studies in large patient cohorts are needed to develop further strategies for identifying patients with dementia in the community setting.
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- 2019
19. COVID-19 lockdown impact on lifestyle habits of Italian adults
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Odone, A., Lugo, A., Amerio, A., Borroni, E., Bosetti, C., Carreras, G., D'Oro, L. C., Colombo, P., Fanucchi, T., Ghislandi, S., Gorini, G., Iacoviello, L., Pacifici, R., Santucci, C., Serafini, G., Signorelli, C., Stival, C., Stuckler, D., Tersalvi, C. A., Gallus, S., Odone, A., Lugo, A., Amerio, A., Borroni, E., Bosetti, C., Carreras, G., D’Oro, L. C., Colombo, P., Fanucchi, T., Ghislandi, S., Gorini, G., Iacoviello, L., Pacifici, R., Santucci, C., Serafini, G., Signorelli, C., Stival, C., Stuckler, D., Tersalvi, C. A., and Gallus, S.
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Adult ,Adolescent ,Pneumonia, Viral ,Short Papers ,Habits ,Young Adult ,Betacoronavirus ,CROSS-SECTIONAL STUDY ,Humans ,Covid-19 ,Cross-sectional study ,Italy ,Lifestyles ,Lockdown ,Aged ,Coronavirus Infections ,Cross-Sectional Studies ,Middle Aged ,Pandemics ,Public Health ,Life Style ,Viral ,SARS-CoV-2 ,COVID-19, LOCKDOWN, LIFESTYLES, ITALY, CROSS-SECTIONAL STUDY ,COVID-19 ,Pneumonia ,LOCKDOWN ,LIFESTYLES - Abstract
In March 2020, when the Government imposed nation-wide lockdown measures to contrast the COVID-19 outbreak, the life of Italians suddenly changed. In order to evaluate the impact of lockdown on lifestyle habits and behavioral risk factors of the general adult population in Italy, we set up the Lost in Italy (LOckdown and lifeSTyles IN ITALY) project. Within this project, the online panel of Doxa was used to conduct a web-based cross-sectional study during the first phase of the lockdown, on a large representative sample of adults aged 18-74 years (N=6003). The self-administered questionnaire included information on lifestyle habits and perceived physical and mental health, through the use of validated scales. As we are working within the Lost in Italy project, we got two additional grants to further research on the medium-term impact of lockdown, a topic of great interest and with anticipated large socio-economic and public health implications. In details: we obtained by the AXA Research Fund support to evaluate the impact of COVID-19 lockdown on physical, mental, and social wellbeing of elderly and fragile populations in the Lombardy region, the area most heavily hit by the pandemic in the country. Moreover, as a fruitful integration, we obtained support by the Directorate General for Welfare of the region to assess health services delivery and access to healthcare in the same study population, combining an analysis of administrative databases with an economic analysis. We are confident that the solid background of our partners, the multi-disciplinary competencies they bring, together with appropriate funding and access to rich data sources will allow us to fulfill our research objectives. (www.actabiomedica.it)
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- 2020
20. Decline in the incidence of colorectal cancer and the associated mortality in young Italian adults
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Zorzi M., Cavestro G. M., Guzzinati S., Dal Maso L., Rugge M., Mazzoleni G., Morrone G., Caputo E., Galasso R., Citarella A., Sampietro G., Magoni M., Cavalieri D'Oro L., Ardizzone A., D'Argenzio A., Sciacca S., Pisani S., Ricci P., Giorno A., Ferretti S., Palma F., Serraino D., Iacovacci S., Quarta F., Filiberti R. A., Vitarelli S., Russo A. G., Carrozzi G., D'Orsi G., Fusco M., Sini G. M., Vitale F., Michiara M., Boschetti L., Chiaranda G., Rosso S., Tumino R., Mangone L., Valenti Clemente S., Falcini F., Caiazzo A. L., Cesaraccio R., Madeddu A., Fanetti A. C., Minerba S., Caldarella A., Candela G., Piffer S., Stracci F., Tagliabue G., Tolin M., Brustolin A., Castelli M., Zorzi M., Cavestro G.M., Guzzinati S., Dal Maso L., Rugge M., Mazzoleni G., Morrone G., Caputo E., Galasso R., Citarella A., Sampietro G., Magoni M., Cavalieri D'Oro L., Ardizzone A., D'Argenzio A., Sciacca S., Pisani S., Ricci P., Giorno A., Ferretti S., Palma F., Serraino D., Iacovacci S., Quarta F., Filiberti R.A., Vitarelli S., Russo A.G., Carrozzi G., D'Orsi G., Fusco M., Sini G.M., Vitale F., Michiara M., Boschetti L., Chiaranda G., Rosso S., Tumino R., Mangone L., Valenti Clemente S., Falcini F., Caiazzo A.L., Cesaraccio R., Madeddu A., Fanetti A.C., Minerba S., Caldarella A., Candela G., Piffer S., Stracci F., Tagliabue G., Tolin M., Brustolin A., Castelli M., Zorzi, M., Cavestro, G. M., Guzzinati, S., Dal Maso, L., and Rugge, M
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0301 basic medicine ,Colon ,Population ,Socio-culturale ,colorectal cancer ,colorectal cancer screening ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Epidemiology of cancer ,Medicine ,Humans ,Risk factor ,education ,education.field_of_study ,cancer epidemiology, Colorectal cancer, colorectal cancer screening ,business.industry ,Incidence (epidemiology) ,Mortality rate ,screening ,Incidence ,Gastroenterology ,Cancer ,medicine.disease ,Obesity ,Annual Percent Change ,Europe ,030104 developmental biology ,Italy ,030211 gastroenterology & hepatology ,epidemiology ,business ,Colorectal Neoplasms ,Demography ,cancer epidemiology ,SEER Program - Abstract
Objective The incidence of colorectal cancer (CRC) declines among subjects aged 50 years and above. An opposite trend appears among younger adults. In Europe, data on CRC incidence among younger adults are lacking. We therefore aimed to analyse European trends in CRC incidence and mortality in subjects younger than 50 years. Design Data on age-related CRC incidence and mortality between 1990 and 2016 were retrieved from national and regional cancer registries. Trends were analysed by Joinpoint regression and expressed as annual percent change. Results We retrieved data on 143.7 million people aged 20–49 years from 20 European countries. Of them, 187 918 (0.13%) were diagnosed with CRC. On average, CRC incidence increased with 7.9% per year among subjects aged 20–29 years from 2004 to 2016. The increase in the age group of 30–39 years was 4.9% per year from 2005 to 2016, the increase in the age group of 40–49 years was 1.6% per year from 2004 to 2016. This increase started earliest in subjects aged 20–29 years, and 10–20 years later in those aged 30–39 and 40–49 years. This is consistent with an age-cohort phenomenon. Although in most European countries the CRC incidence had risen, some heterogeneity was found between countries. CRC mortality did not significantly change among the youngest adults, but decreased with 1.1%per year between 1990 and 2016 and 2.4% per year between 1990 and 2009 among those aged 30–39 years and 40–49 years, respectively. Conclusion CRC incidence rises among young adults in Europe. The cause for this trend needs to be elucidated. Clinicians should be aware of this trend. If the trend continues, screening guidelines may need to be reconsidered.
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- 2020
21. Liver cirrhosis and the risk of primary liver cancer
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La Vecchia, C, Negri, E, d'Oro, L Cavalieri, and Franceschi, S
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- 1998
22. Antimicrobial activity of Metschnikowia pulcherrima on wine yeasts
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Oro, L., Ciani, M., and Comitini, F.
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- 2014
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23. Pediatric selective mutism and sleep disorders: A pilot restrospective case control-study
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Marotta, R, Giordano, R., Caliendo, M, Nuara, T, Folco, ADI, Salerno, M, Testa, D, Gallai, B, Cerroni, F, D'Oro, L, Russo, D, Parisi, L, Quatrosi, G, Esposito, V, Romano, P, Marsala, G, Montana, A, Franco, S, Geraci, D, Chisari, MG, Picciocchi, E, Polito, AN, Murabito, P, Giugliano, P, Tripi, G, Marotta, R, Giordano, R., Caliendo, M, Nuara, T, Folco, ADI, Salerno, M, Testa, D, Gallai, B, Cerroni, F, D'Oro, L, Russo, D, Parisi, L, Quatrosi, G, Esposito, V, Romano, P, Marsala, G, Montana, A, Franco, S, Geraci, D, Chisari, MG, Picciocchi, E, Polito, AN, Murabito, P, Giugliano, P, and Tripi, G
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Sleep disorder ,Sleep Disturbance Scale for Children ,Selective mutism ,Sleep disorders - Abstract
Introduction: Selective mutism (SM) is characterized by the persistent inability to speak in some specific contexts (i.e. school, home, social contexts) or within interaction with peer group and/or adults when a normal verbal linguistic competence may be expected, according to DSM5 criteria. The main sleep disorders in children with neurodevelopmental disorders are represented by difficulty in falling asleep at night (51%) and nocturnal awakenings (67%).The main goal of the present study is verify the putative relationship between sleep disorders and selective mutism in children.Materials and methods: 30 children were diagnosed with SM (13 males and 17 females) with mean age 9.47 (SD +/- 129). The case-control group was composed by 30 typically developing children (TDC) (12 males and 18 females) (mean age 8.95; SD +/- 2.01; p = 0238). All the subjects of both groups were recruited within the same urban area, Caucasian and homogeneous in socio-economic level. SDSC questionnaire was used in order to assess the sleep habits in both groups.Results: The two groups (SM and TDC) were similar for age and gender. About the presence of reported sleep disorders, SM children show a significantly higher prevalence of reported sleep troubles than TDC subjects (Graph 1).Conclusion: The present pilot restrospective case control-study has shown the presence of sleep disorders in children with SM. This new comorbidity has not been previously reported in clinical literature.
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- 2019
24. Sustainability of the Italian National Health Service
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Madotto, F, Mantovani, LG, Riva, MA, Fornari, C, Cortesi, PA, Conti, S, Giupponi, M, Cavalieri d'Oro, L, Scalone, L, Cesana, G, Madotto, F, Mantovani, L, Riva, M, Fornari, C, Cortesi, P, Conti, S, Giupponi, M, Cavalieri d'Oro, L, Scalone, L, and Cesana, G
- Subjects
National Health Service ,Sustainability ,Public Health, Environmental and Occupational Health - Published
- 2018
25. Short and long-term mortality in elderly patients with suspected not confirmed pulmonary embolism
- Author
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Polo Friz, H, Orenti, A, Brambilla, M, Caleffi, A, Pezzetti, V, Cavalieri d'Oro, L, Giannattasio, C, Vighi, G, Cimminiello, C, Boracchi, P, Polo Friz, Hernan, Orenti, Annalisa, Brambilla, Mattia, Caleffi, Alessandro, Pezzetti, Valentina, Cavalieri d'Oro, Luca, Giannattasio, Cristina, Vighi, Giuseppe, Cimminiello, Claudio, Boracchi, Patrizia, Polo Friz, H, Orenti, A, Brambilla, M, Caleffi, A, Pezzetti, V, Cavalieri d'Oro, L, Giannattasio, C, Vighi, G, Cimminiello, C, Boracchi, P, Polo Friz, Hernan, Orenti, Annalisa, Brambilla, Mattia, Caleffi, Alessandro, Pezzetti, Valentina, Cavalieri d'Oro, Luca, Giannattasio, Cristina, Vighi, Giuseppe, Cimminiello, Claudio, and Boracchi, Patrizia
- Abstract
Introduction: Most patients evaluated for suspected pulmonary embolism(PE) conclude the Emergency Department(ED) work-up with a diagnosis of PE not confirmed(PE excluded;PE-E). We aimed to investigate the clinical features, short and long-term mortality, and prognostic factors for death in elderly with PE-E, and to compare these figures with those of patients with PE confirmed(PE-C). Methods: Consecutive patients ≥65 years old evaluated in the ED for clinically suspected hemodynamically stable acute PE were included in this retrospective cohort study. Results: Study population: 657 patients with suspected PE, PE-C:162(24.65%). When compared with PE-C, patients with PE-E presented a higher prevalence of chronic cardiopulmonary disease (17.37% vs 8.02%, p = 0.003), a lower prevalence of pulse rate >110 (13.13% vs 25.93%; p<0.001), of arterial oxygen saturation <90% (16.16% vs. 25.93%; p = 0.007) and of hospitalized patients (52.93% vs 98.15%; p < 0.001). Thirty-day, 90-day, 1-year, 2-year and 5-year overall mortality was 8.83%, 15.98%, 23.59%, 29.68%, and 51.09%, respectively, differences between PE-E and PE-C non statistically significant. Among patients with PE-E, multivariate analysis showed that simplified Pulmonary Embolism Severity Index score>0 was associated with higher short and long-term mortality (30-day:HR:5.31,p = 0.029; 5 year:HR:2.18, p < 0.001), meanwhile comorbidity (Charlson Comorbidity Index>0) only with higher long-term mortality (30-day: HR:1.60, p = 0.342; 5 year: HR:1.41, p = 0.038). Conclusion: In real world haemodinamically stable elderly patients evaluated in the ED for suspected PE, short and long-term mortality was markedly high regardless whether PE was confirmed or excluded. At the time to set management and follow up strategies, elderly patients with PE excluded should not be considered a low-risk population.
- Published
- 2020
26. Forensic considerations on violent parasomnias during lifespan
- Author
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Sessa, F., Franco, S., Picciocchi, E., Geraci, D., Chisari, M. G., Marsala, G., Polito, A. N., Sorrentino, M., Tripi, G., Salerno, M., Russo, D., Lavano, S. M., Cerroni, F., Romano, P., Gallai, B., Marotta, R., Lavano, F., Magliulo, R. M., D'Oro, L., Di Folco, A., Parisi, L., Testa, D., Murabito, P., Sessa F., Franco S., Picciocchi E., Geraci D., Chisari M.G., Marsala G., Polito A.N., Sorrentino M., Tripi G., Salerno M., Russo D., Lavano S.M., Cerroni F., Romano P., Gallai B., Marotta R., Lavano F., Magliulo R.M., D'Oro L., Di Folco A., Parisi L., Testa D., and Murabito P.
- Subjects
Consciousness ,Guiltiness ,NREM parasomnias ,Sleep ,Consciousne ,Guiltine ,NREM parasomnia ,consciousness ,guiltiness ,sleep - Abstract
Nocturnal parasomnias are a group of sleep complex manifestation that don't alter the sleep macrostructure, but when persistent during adulthood may be assume violent aspects with relevant forensic implications about the guiltiness.
- Published
- 2018
27. Eating and feeding disorders in pediatric age
- Author
-
Gallai, B, Tripi, G, Lavano, F, Lavano, Sm, Romano, P, Cerroni, F, Russo, D, Cerron, F, D'Oro, L, Franco, S, Picciocchi, E, Geraci, D, Chisari, Mg, Polito, An, Sorrentino, M, Magliulo, Rm, Di Folco, A, Parisi, L, Testa, D, Murabito, P, Marotta, R, Gallai B., Tripi G., Lavano F., Salerno M., Lavano S.M., Romano P., Cerroni F., Russo D., D'Oro L., Franco S., Picciocchi E., Geraci D., Chisari M.G., Polito A.N., Sorrentino M., Magliulo R.M., Di Folco A., Parisi L., Testa D., Murabito P., and Marotta R.
- Subjects
anorexia nervosa ,feeding troubles ,eating disorders ,Anorexia nervosa ,Eating disorders ,Feeding troubles ,Eating disorder - Abstract
Eating and feeding disorders are common in pediatric age and may be important to discover and recover the early symptoms in order to optimize the treatment and management.
- Published
- 2018
28. Motor skills in children with primary headache: A pilot case-control study
- Author
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Polito, A. N., Picciocchi, E., Geraci, D., Chisari, M. G., Marsala, G., Sorrentino, M., Tripi, G., Salerno, M., Russo, D., Lavano, S. M., Cerroni, F., Romano, P., Marotta, R., Lavano, F., Magliulo, R. M., D'Oro, L., Di Folco, A., Parisi, L., Testa, D., Murabito, P., Gallai, B., Polito A.N., Picciocchi E., Geraci D., Chisari M.G., Marsala G., Sorrentino M., Tripi G., Salerno M., Russo D., Lavano S.M., Cerroni F., Romano P., Marotta R., Lavano F., Magliulo R.M., D'Oro L., Di Folco A., Parisi L., Testa D., Murabito P., and Gallai B.
- Subjects
primary headaches ,migraine without aura ,motor skills ,Primary headaches ,Migraine without aura ,Motor skill ,Motor skills - Abstract
Background: Headache is the most common painful manifestation in the developmental age, often accompanied by severe disability such as scholastic absenteeism, low quality of academic performance and compromised emotional functioning. The aim of the study is to evaluate praxic abilities in a population of children without aural migraine. Materials and methods: The test population consists of 10 subjects without migraine without aura (MwA), (8 Males) (mean age 8.40, SD ± 1.17) and 11 healthy children (7 Males) (mean age 8.27; SD ± 1.10; p = 0.800). All subjects underwent evaluation of motor coordination skills through the Battery for Children Movement Assessment (M-ABC). Results: The two groups (10 MwA vs 11 Controls) were similar for age (8.40 ± 1.17 vs 8.27 ± 1.10; p = 0.800), sex (p = 0.730), and BMI (p = 0.204). The migraine subjects show an average worse performance than the Movement ABC; specifically, migraineurs show significantly higher total score values (31.00 ± 23.65 vs 4.72 ± 2.61; p = 0.001), manual dexterity (12.10 ± 11.20 vs 2.04 ± 2.65; p = 0.009) and balance (14.85 ± 10.08 vs. 1.04 ± 1.05; p
- Published
- 2018
29. Beneficial effects of pasta during pregnancy: The positive effects of mediterranean diet
- Author
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Messina, A., Picciocchi, E., Monda, V., Valenzano, A., Cibelli, G., Ruberto, V., Pisanelli, D., Polito, A. N., Marsala, G., Di Palma, A., Barone, A. V., Monda, M., Ruberto, M., Gallai, B., Tripi, G., Lavano, F., Salerno, M., Lavano, S. M., Romano, P., Cerroni, F., Russo, D., D'Oro, L., Sorrentino, M., Magliulo, R. M., Di Folco, A., Parisi, L., Testa, D., Marotta, R., Messina, G., Messina A., Picciocchi E., Monda V., Valenzano A., Cibelli G., Ruberto V., Pisanelli D., Polito A.N., Marsala G., Di Palma A., Barone A.V., Monda M., Ruberto M., Gallai B., Tripi G., Lavano F., Salerno M., Lavano S.M., Romano P., Cerroni F., Russo D., D'Oro L., Sorrentino M., Magliulo R.M., Di Folco A., Parisi L., Testa D., Marotta R., Messina G., Messina, Antonietta, Picciocchi, Elisabetta, Monda, Vincenzo, Valenzano, Anna, Cibelli, Giuseppe, Ruberto, Valentina, Pisanelli, Daniela, Polito, Anna Nunzia, Marsala, Gabriella, Di Palma, Antonella, Barone, Antonia Vanessa, Monda, Marcellino, Ruberto, Maria, Gallai, Beatrice, Tripi, Gabriele, Lavano, Francesco, Salerno, Margherita, Lavano, Serena Marianna, Romano, Palmira, Cerroni, Francesco, Russo, Daniela, D'Oro, Lucrezia, Sorrentino, Michele, Magliulo, Rosaria Martina, Di Folco, Annabella, Parisi, Lucia, Testa, Davide, Marotta, Rosa, and Messina, Giovanni
- Subjects
Pregnancy ,Medicine (all) ,Mediterranean diet ,Pasta ,food and beverages ,Diet ,Nutrition - Abstract
Pregnancy is a physiological state during which the woman's body undergoes profound modifications. During this time, every woman must be nourished in such a way as to maintain herself in good health and at the same time allow the fetal tissues to form and develop in the best way. Proper nutrition is one of the fundamental prerequisites for the normal evolution of both pregnancy and fetal growth: the quantity and quality of food and drinks must be scrupulously controlled. Contrariwise, it is important to avoid the excess calories and macronutrients. In fact, during pregnancy, it may be just as harmful as their shortage, especially in overweight and obese women, for which the risk of miscarriage, gestational diabetes, fetal growth disorders and preeclampsia increases. The pasta constitutes the foundation of the Mediterranean diet food. The dough can be seen, therefore, so it represents an excellent ally of the diet from a nutritional point of view. The nutritional values of the pasta change depending on the type, based on the fact that the dough is traditional or integral semolina. It also contains Vitamin B and has an abundance of minerals, among which potassium. The pasta is an easily digestible food, ensuring energy ready to use (such as all carbohydrates); moreover, it possesses a great satiating power. In case of overweight, however, it is possible to reduce the number of carbohydrates in the diet, taking care not to make them ever miss. In conclusion, the consumption of pasta is very important during pregnancy: a diet without carbohydrates can be dangerous for all physiological pathways.
- Published
- 2018
30. Psychopathological and psychodynamic hypotheses for pediatric stuttering
- Author
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Grieco M., Salerno M., Tripi G., Lavano F., Romano P., Russo D., Lavano S. M., Cerroni F., Marotta R., D'Oro L., Franco S., Picciocchi E., Geraci D., Chisari M. G., Marsala G., Polito A. N., Sorrentino M., Magliulo R. M., Di Folco A., Parisi L., Testa D., Murabito P., Giugliano P., Gallai B., Grieco M., Salerno M., Tripi G., Lavano F., Romano P., Russo D., Lavano S.M., Cerroni F., Marotta R., D'Oro L., Franco S., Picciocchi E., Geraci D., Chisari M.G., Marsala G., Polito A.N., Sorrentino M., Magliulo R.M., Di Folco A., Parisi L., Testa D., Murabito P., Giugliano P., and Gallai B.
- Subjects
Anxiety disorder ,Anxiety disorders ,Pediatric stuttering ,Psychodynamic hypotheses - Abstract
Stuttering is a common language alteration in pediatric age consisting in repetitions and blocks, which entail a break in the rhythm and melody of the speech. According to the WHO it is a disorder of the rhythm of the word, the subject knows precisely what he would like to say, but at the same time he is not able to say it. It is a great inconvenience for those affected, also because the slowing down of speaking is not about thought or cognitive skills.
- Published
- 2018
31. Visuospatial skills in children affected by primary nocturnal enuresis: Rehabilitative proposals
- Author
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Lavano F., Testa D., Lavano S. M., Marotta R., Tripi G., Salerno M., Romano P., Di Folco A., Gallai B., Russo D., D'Oro L., Sorrentno M., Magliulo R. M., Cerroni F., Marsala G., Montana A., Franco S., Geraci D., Chisari M. G., Picciocchi E., Polito A. N., Murabito P., Parisi L., Lavano F., Testa D., Lavano S.M., Marotta R., Tripi G., Salerno M., Romano P., Di Folco A., Gallai B., Russo D., D'Oro L., Sorrentno M., Magliulo R.M., Cerroni F., Marsala G., Montana A., Franco S., Geraci D., Chisari M.G., Picciocchi E., Polito A.N., Murabito P., and Parisi L.
- Subjects
Nocturnal enuresi ,Visuospatial skills ,Rehabilitation ,Nocturnal enuresis - Abstract
The sphincterial control problems in childhood are very common, with relevant comorbidities (i.e.: difficulty in academic performance, sleep disturbances, minor neurological signs) involved in the complex process of maturation and learning, such as to cause a great deal of discomfort and related disorders in affected subjects. Enuresis is characterized by the involuntary urination in the absence of a physical disorder, socially unacceptable in places and at one stage of life where such control is acquired by the majority of subjects (about 5 years). The present study aims to evaluate the visuospatial skills in children affected by primary monosymptomatic nocturnal enuresis (PMNE). 31 PMNE children (16 males and 15 females) (mean age 10.87, SD ± 1.68) and 61 healthy children (32 males, 29 females) (mean age 11.03, SD ± 1.85, p = 0687) were evaluated for visuomotor skills with the Visual-Motor Integration Scale (VMI). PMNE subjects show a worse performance on average to VMI, especially in the total visual-motor integration test. This finding emphasizes the importance of a framework for global and more complex than is commonly implemented, across the border but framing the subject of enuretic symptoms in a more global perspective.
- Published
- 2018
32. Animals-assisted therapy: A brief review
- Author
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Pennacchio S., Tripi G., Salerno M., Russo D., Lavano S. M., Cerroni F., Marotta R., Romano P., Gallai B., Giugliano P., Murabito P., Sorrentino M., Magliulo R. M., D'Oro L., Di Folco A., Testa D., Marsala G., Geraci D., Chisari M. G., Picciocchi E., Lavano F., Parisi L., Ruberto M., Pennacchio S., Tripi G., Salerno M., Russo D., Lavano S.M., Cerroni F., Marotta R., Romano P., Gallai B., Giugliano P., Murabito P., Sorrentino M., Magliulo R.M., D'Oro L., Di Folco A., Testa D., Marsala G., Geraci D., Chisari M.G., Picciocchi E., Lavano F., Parisi L., and Ruberto M.
- Subjects
Dogs ,Neurodevelopmental disorders ,Dog ,Animals-assisted therapy - Abstract
In rehabilitative setting, the presence of animals can be considered as an important stimulus for verbal and social communication, and for mood regulation. Interaction with an animal is beneficial for children's development and numerous psychological tests have revealed that growing up with pets has a beneficial effect on children's self-esteem and self-confidence, can improve empathy, a sense of responsibility and cognitive development, as well as social status within the peer group.
- Published
- 2018
33. Comorbidity burden conditions the prognostic performance of D-dimer in elderly patients with acute pulmonary embolism
- Author
-
POLO FRIZ, H, Pezzetti, V, Orenti, A, Caleffi, A, Corno, V, Crivellari, C, Petri, F, Polo Friz, M, Punzi, V, Teruzzi, D, D'Oro, L, Giannattasio, C, Vighi, G, Cimminiello, C, Boracchi, P, POLO FRIZ, HERNAN FRANCISCO, Pezzetti, Valentina, Orenti, Annalisa, Caleffi, Alessandro, Corno, Valeria, Crivellari, Chiara, Petri, Francesco, Polo Friz, Melisa, Punzi, Veronica, Teruzzi, Daniela, d'Oro, Luca Cavalieri, Giannattasio, Cristina, Vighi, Giuseppe, Cimminiello, Claudio, BORACCHI, PATRIZIA, POLO FRIZ, H, Pezzetti, V, Orenti, A, Caleffi, A, Corno, V, Crivellari, C, Petri, F, Polo Friz, M, Punzi, V, Teruzzi, D, D'Oro, L, Giannattasio, C, Vighi, G, Cimminiello, C, Boracchi, P, POLO FRIZ, HERNAN FRANCISCO, Pezzetti, Valentina, Orenti, Annalisa, Caleffi, Alessandro, Corno, Valeria, Crivellari, Chiara, Petri, Francesco, Polo Friz, Melisa, Punzi, Veronica, Teruzzi, Daniela, d'Oro, Luca Cavalieri, Giannattasio, Cristina, Vighi, Giuseppe, Cimminiello, Claudio, and BORACCHI, PATRIZIA
- Abstract
Introduction: The prognostic accuracy of D-dimer for risk assessment in acute Pulmonary Embolism (APE) patients may be hampered by comorbidities. We investigated the impact of comorbidity burden (CB) by using the Charlson Comorbidity Index (CCI), on the prognostic ability of D-dimer to predict 30 and 90-day mortality in hemodynamically stable elderly patients with APE. Methods: All patients aged >65 years with normotensive APE, consecutively evaluated in the Emergency Department since 2010 through 2014 were included in this retrospective cohort study. Area under the curve (AUC) and 1⁄2 Net Reclassification Improvement (NRI) were calculated. Results: Study population: 162 patients, median age: 79.2 years. The optimal cut-off value of CCI score for predicting mortality was ≤1 (Low CB) and >1 (High CB), AUC = 0.786. Higher levels of D-dimer were associated with an increased risk death at 30 (HR = 1.039, 95%CI:1.000–1.080, p = 0.049) and 90 days (HR = 1.039, 95%CI:1.009–1.070, p = 0.012). When added to simplified Pulmonary Embolism Severity Index (sPESI) score, D-dimer increased significantly the AUC for predicting 30-day mortality in Low CB (AUC = 0.778, 95%CI:0.620–0.937, 1⁄2NRI = 0.535, p = 0.015), but not in High CB patients (AUC = 0.634, 95%CI:0.460–0.807, 1⁄2 NRI = 0.248, p = 0.294). Similarly, for 90-day mortality D-dimer increased significantly the AUC in Low CB (AUC = 0.786, 95%CI:0.643–0.929, 1⁄2NRI = 0.424, p-value = 0.025), but not in High CB patients (AUC = 0.659, 95%CI:0.541–0.778, 1⁄2NRI = 0.354, p-value = 0.165). Conclusion: In elderly patients with normotensive APE, comorbidities condition the prognostic performance of D-dimer, which was found to be a better predictor of death in subjects with low CB. These results support multimarker strategies for risk assessment in this population.
- Published
- 2019
34. Impatto dei trend demografici ed epidemiologici sulla sostenibilità del SSN
- Author
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Madotto, F, Mantovani, LG, Riva, MA, Fornari, C, Giupponi, M, Cavalieri D’Oro, L, Scalone, L, Cesana, GC, Madotto, F, Mantovani, L, Riva, M, Fornari, C, Giupponi, M, Cavalieri D’Oro, L, Scalone, L, and Cesana, G
- Subjects
Sostenibilità, Servizio Sanitario Nazionale - Published
- 2017
35. MOTION SICKNESS IN CHILDHOOD MIGRAINE
- Author
-
MALTESE, Agata, GALLAI, B, ROMANO, P, D’ORO, L, MAROTTA, R, LAVANO, F, LAVANO, SM, TRIPI, G, SALERNO, M., MALTESE, A, GALLAI, B, ROMANO, P, D’ORO, L, MAROTTA, R, LAVANO, F, LAVANO, SM, TRIPI, G, and SALERNO, M
- Subjects
childhood migraine, periodic syndromes, Abdominal Migraine, Motion Sickness, Cyclic Vomiting, Growing Pains - Abstract
Background: Migraine is a chronic, progressive, and debilitating disorder that has an impact on the lives of millions of individuals. The origins of the disability can be traced into childhood and adolescence for most adult migraine sufferers. The group of periodic syndromes consists in symptoms related to migraine, thought to be migraine equivalent or precursors. Aim of this study is to assess the role of MS as risk factors for childhood migraine. Materials and methods: 441 subjects (211 Females) aged 6-13 years (mean 9.20; SD 2.42), consecutively referred between October 2007 to March 2009 for primary headaches to pediatric Centers for Headache in Childhood. Control group consisted of 365 subjects (175 F) aged 7-13 years (mean 9.08; SD 3.02). Results: Two groups were not different for age (F=0.390; p=0.539) and sex ratio (Chi-square=0.002; p=0.966). Headache percentage distribution was the following: MoA 38.32%, MA 11.11%, FETTH 16.78%, CTTH 20.63%. Logistic regression shows a greater OR for CVS and MS associated for migraine group (MoA and MA patients), respectively 8.28 (IC95% 2.35 - 29.16) for CVS and 5.22 (IC95% 3.5 - 7.77); moreover, CVS cause a consistent increase in OR of 3.69 (IC95% 2.21 - 6.17) also for headache group (CTTH and FETTH patients). Discussion: Periodic syndromes could be considered the natural precursors of migraine almost but not only in children, as reported in some studies in adulthood.
- Published
- 2017
36. Neurosciences and attachment theory: A brief review
- Author
-
MALTESE, Agata, GALLAI, B, MAROTTA, R, LAVANO, F, LAVANO, S. M, TRIPI, G, ROMANO, P, D’ORO, L, SALERNO, M., MALTESE, A, GALLAI, B, MAROTTA, R, LAVANO, F, LAVANO, S.M, TRIPI, G, ROMANO, P, D’ORO, L, and SALERNO, M
- Subjects
attachment theory, neurosciences, fMRI, cortisol ,FMRI ,Neurosciences ,Attachment theory ,Cortisol - Abstract
The attachment theory was proposed and elaborated by John Bowlby. Over the last ten years the attachment theory has attracted considerable interest in the field of mental health as it emphasizes how relationships that are established in the earliest stages of development have an impact on man in an indefinable and lifelong manner.
- Published
- 2017
37. THE DYNAMIC MATURATIVE MODEL FOR ATTACHMENT
- Author
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MALTESE, Agata, GALLAI, B, ROMANO, P, D’ORO, L, MAROTTA, R, LAVANO,F, LAVANO, SM, TRIPI, G, SALERNO, M., MALTESE,A, GALLAI, B, ROMANO, P, D’ORO, L, MAROTTA, R, LAVANO,F, LAVANO, SM, TRIPI, G, and SALERNO, M
- Subjects
Intersubjectivity ,Settore M-PSI/04 - Psicologia Dello Sviluppo E Psicologia Dell'Educazione ,Attachment style ,Dynamic maturative model ,dynamic maturative model, attachment style, intersubjectivity - Abstract
The Dynamic-Maturation Model (DMM) was developed by Patricia Crittenden (1-4), which focused its studies on attachment to different ethnic, socio-cultural and dangers as families in which episodes of Maltreatment and abuse or families with high psychosocial risk. Crittenden proposes new protocols of the Strange Situation (SS) and the Adult Attachment Interview (AAI) based on a coding and classification system derived from the model proposed by Ainsworth, but modified and enriched with that of Main, Goldwyn and Hesse. The SS procedure, adopted for children aged between 10 and 18 months, is valid until all preschool age, assuming This way the name of the Preschool Assessment of Attachment (PAA).
- Published
- 2017
38. THE SYNACTIVE THEORY OF DEVELOPMENT: THE KEYWORD FOR NEURODEVELOPMENTAL DISORDERS
- Author
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Maltese, A., Gallai, B., Marotta, R., Lavano, F., Lavano, S., Tripi, G., Romano, P., D’Oro, L., Salerno, M., MALTESE, A, GALLAI, B, MAROTTA, R, LAVANO, F, LAVANO, S.M, TRIPI, G, ROMANO, P, D’ORO, L, and SALERNO, M
- Subjects
Settore M-PSI/04 - Psicologia Dello Sviluppo E Psicologia Dell'Educazione ,Autonomic nervous system ,Sleep ,Synactive Theory of Development ,Synactive Theory of Development, autonomic nervous system, sleep - Abstract
The synactive theory of development may be considered the keyword for neurodevelopmental disorders, considering that each one presents constantly autonomic troubles such as sleep disorders, feeding problems.
- Published
- 2017
39. Psychopathological and psychodynamic hypotheses for pediatric stuttering
- Author
-
Grieco, M, Tripi, G, Lavano, F, Romano, P, Russo, D, Lavano, Sm, Cerroni, F, Marotta, R, D'Oro, L, Franco, S, Picciocchi, E, Geraci, D, Chisari, Mg, Marsala, G, Polito, An, Sorrentino, M, Magliulo, Rm, Di Folco, A, Parisi, L, Testa, D, Murabito, P, Giugliano, P, and Gallai, B
- Subjects
pediatric stuttering ,psychodynamic hypotheses ,anxiety disorders - Published
- 2018
40. Visuospatial skills in children affected by primary nocturnal enuresis: rehabilitative proposals
- Author
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Lavan, F, Testa, D, Lavan, Sm, Marotta, R, Tripi, G, Romano, P, Di Folco, A, Gallai, B, Russo, D, D'Oro, L, Sorrentno, M, Magliulo, Rm, Cerroni, F, Marsala, MARILENA GRAZIA, Montana, Angelo, Franco, S, Geraci, D, Chisari, Mg, Picciocchi, E, Polito, An, Murabito, Paolo, and Parisi, L
- Subjects
nocturnal enuresis ,rehabilitation ,visuospatial skills - Published
- 2018
41. Cancer incidence in children and young adults living in industrially contaminated sites: from the Italian experience to the development of an international surveillance system
- Author
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Iavarone, I, Buzzoni, C, Stoppa, G, Steliarova-Foucher, E, Ardizzone, A, Barchielli, A, Borciani, E, Boschetti, L, Brustolin, A, Caiazzo, M, Candela, G, Carrozzi, G, Cavalieri D'Oro, L, Cesaraccio, R, Contiero, P, Contrino, Ml, Coviello, V, Falcini, F, Fanetti, Ac, Ferretti, S, Filiberti, R, Galasso, R, Giorno, A, Grappasonni, I, Magoni, M, Mangone, L, Mazzoleni, G, Melcarne, A, Michiara, M, Minerba, A, Pannozzo, F, Piffer, S, Pisani, S, Ricci, P, Rugge, M, Russo, Ag, Sacerdote, C, Sanpietro, G, Sciacca, S, Stracci, F, Sutera, A, Tagliabue, G, Tumino, R, Usala, M, Vitale, F, and Zanetti, R.
- Subjects
Adult ,Male ,Internationality ,Adolescent ,Epidemiology ,Incidence ,Environmental and Occupational Health ,Infant, Newborn ,Socio-culturale ,Infant ,Europe ,Young Adult ,Italy ,Child, Preschool ,Neoplasms ,Public Health, Environmental and Occupational Health ,Humans ,Industry ,Female ,Public Health ,Child ,Environmental Pollution ,Environmental Monitoring - Abstract
this paper is based upon work from COST Action ICSHNet. Children's environmental health is on the 2030 Agenda for Sustainable Development. The incidence of childhood cancer is increasing worldwide and in Europe. Yet, the aetiology of most childhood cancers, including the role of environmental carcinogens, is still largely unknown. Contaminated areas, especially of industrial origin, are of high concern due to complex mix of hazardous pollutants and their potential health impacts on human populations, notably in children.to describe cancer risk in children and young adults (YA) residing in national priority contaminated sites (NPCSs) in Italy and to provide a suitable framework for a development of cancer surveillance in industrially contaminated sites (ICSs) in Europe.this study is based on a collaborative work of the Italian Institute of Health (ISS) and the Italian Association of Cancer Registries (AIRTUM), in the context of the SENTIERI project (Epidemiological study of residents in National Priority Contaminated Sites). Incidence rates were standardised according to the European standard population. The number of observed cases was compared to the expected cases derived from the age-, sex-, and cancer-specific incidence rates of the national pool of AIRTUM registries for the period 2006-2013. Standardized incidence ratios (SIRs) and 90% confidence intervals (CIs) were computed. The study reports the cancer profile in all combined 28 NPCSs covered by 22 cancer registries.1,050 cases of malignant tumours (MTs) were recorded among 3,161,786 person-years in people aged 0-29 years in 28 NPCSs (SIR: 1.03; 90%CI 0.98-1.09), with an age-standardised incidence rate of 317 per million. Excess risks were observed for: MT of the central nervous system in the age-group1 year (SIR: 3.2; 90%CI 1.4-6.3); soft tissue sarcoma in the age-group 0-14 years (SIR: 1.6; 90%CI 1.1-2.3); acute myeloid leukaemia in the agegroup 0-14 years (SIR: 1.7; 90%CI 1.1-2.4); non-Hodgkin lymphoma in the age-group 20-24 years (SIR 1.5; 90%CI 1.1-2.1), and germ cell tumours of male gonads in the age-group 20-29 years (SIR: 1.33; 90%CI 1.1-1.5). A deficit of cases was observed for Hodgkin lymphomas in the age-group 20-29 years (SIR 0.8; 90%CI 0.6-1.0).this study, which is based on standardized methods and accredited information sources, supports the hypothesis that living in an NPCS increases the risk of some cancer types in children and young adults. Further work will concern groups of NPCSs characterised by common sources of contamination/key carcinogenic pollutants. In fact, in a novel project proposal we aim to monitor the cancer profile in children living in ICSs in Europe. The new project, based on the SENTIERI-AIRTUM methodology, will build on the networking activities of the COST Action on Industrially Contaminated Sites and Health Networking (ICSHNet) and childhood cancer studies coordinated by the International Agency for research on Cancer (IARC).
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- 2018
42. Retracted: Corpus callosum agenesia a minireview
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Ruberto, M, Gallai, B, Tripi, G, Lavano, F, Lavano, Sm, Romano, P, Russo, D, Marotta, R, Franco, S, Picciocchi, E, Geraci, D, Chisari, Mg, Marsala, G, Polito, An, Sorrentino, M, Magliulo, Rm, D'Oro, L, Di Folco, A, Parisi, L, Testa, D, Murabito, P, Giugliano, P, and Cerroni, F
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corpus callosum ,agenesia ,cerebral abnormalities - Published
- 2018
43. Neuropsychomotricity in water: a new rehabilitative tool for neruodevelopmental disorders
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Ruberto, M, Gallai, B, Tripi, G, Lavano, F, Lavano, Sm, Romano, P, Russo, D, Marotta, R, Franco, S, Picciocchi, E, Geraci, D, Chisari, Mg, Marsala, G, Polito, An, Sorrentino, M, Magliulo, Rm, D'Oro, L, Di Folco, A, Parisi, L, Testa, D, Murabito, P, and Cerroni, F
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neuropsychomotricity ,pediatric rehabilitation ,water - Published
- 2018
44. Behavioral aspects in children's brothers affected by Autism Spectrum Disorders
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Sorrentino, M., Tripi, G., Salerno, M., Russo, D., Lavano, S. M., Cerroni, F., Romano, P., Gallai, B., Marotta, R., Lavano, F., Magliulo, R. M., D'Oro, L., Di Folco, A., Testa, D., Marsala, G., Montana, A., Franco, S., Geraci, D., Chisari, M. G., Picciocchi, E., Polito, A. N., Murabito, P., Ruberto, M., Parisi, L., and MICHELE SORRENTINO, GABRIELE TRIPI, MARGHERITA SALERNO, DANIELA RUSSO, SERENA MARIANNA LAVANO, FRANCESCO CERRONI, PALMIRA ROMANO, BEATRICE GALLAI, ROSA MAROTTA, FRANCESCO LAVANO, ROSARIA MARTINA MAGLIULO, LUCREZIA D’ORO, ANNABELLA DI FOLC, DAVIDE TEST, GABRIELLA MARSALA, ANGELO MONTANA, SABRINA FRANCO, DIEGO GERACI, MARIO GIUSEPPE CHISARI, ELISABETTA PICCIOCCHI, ANNA NUNZIA POLITO, PAOLO MURABITO, MARIA RUBERT, LUCIA PARISI
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behavior ,Autism spectrum disorders ,siblings ,Autism spectrum disorders, siblings, behavior ,Behavior ,Siblings - Abstract
Introduction: Autistic Spectrum Disorder (ASD) is a permanent and complex disability arising within the first three years of life characterized by a socio-communicative disorder and by fixed interests and repetitive behaviors. The present pilot study aims to evaluate behavioral aspects in a small population of siblings of ASD children. Material and methods: Population: 5 school-aged children (2 males, 3 females) (mean age 9.235 ± 2.041) were enrolled, as siblings of ASD children, and for comparison, 12 healthy (7 males, 5 females) children (average age 9,528 ± 3,351). All subjects underwent evaluation of the behavioral with Child Behavior Checklist (CBCL) scale. Results: The two groups were statistically comparable by age (p = 0.86) and gender distribution (p = 0.87). From the behavioral point of view evaluated with the CBCL scale, siblings of ASD have a higher degree of overall problem (Total problems) compared to control children (p=0.003), in addition they have significantly higher scores in the subscales of behavior examined (Anxious/Depressed, Withdrawn, Somatic Complaints, Social, Thought, Attention, Delinquent, Aggressive) as well as a greater share of disturbances both internalizing (p=0.004) and externalizing (p = 0.007) (Table 1). Conclusions: The present preliminary data confirm the need for a global management of the entire family structure for the correct management of Autistic Disorders.
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- 2018
45. Corpus callosum agenesia a minireview
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Ruberto, M., Gallai, B., Tripi, G., Lavano, F., Salerno, M., Lavano, S. M., Romano, P., Russo, D., Marotta, R., Franco, S., Picciocchi, E., Geraci, D., Chisari, M. G., Marsala, G., Polito, A. N., Sorrentino, M., Magliulo, R. M., D'Oro, L., Di Folco, A., Parisi, L., Testa, D., Murabito, P., Giugliano, P., and Cerroni, F.
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Cerebral abnormalities ,Corpus callosum ,Agenesia - Published
- 2018
46. Animals-assisted therapy: a brief review
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Pennacchio, S, Tripi, Giuseppe, Salerno, M, Russo, Da, Lavano, Sm, Cerroni, F, Marotta, R, Romano, P, Gallai, B, Giugliano, P, Murabito, P, Sorrentino, M, Magliulo, Rm, D'Oro, L, Di Folco, A, Testa, D, Marsala, MARILENA GRAZIA, Geraci, D, Chisari, Mg, Picciocchi, E, Lavano, F, Parisi, L, and Ruberto, M
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animals-assisted therapy ,neurodevelopmental disorders ,dogs - Published
- 2018
47. Cancer incidence and mortality trends from 2003 to 2014 in Italy
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Buzzoni, Carlotta, primary, Crocetti, Emanuele, additional, Guzzinati, Stefano, additional, Dal Maso, Luigino, additional, Francisci, Silvia, additional, Mazzoleni, G, additional, Ferrara, MA, additional, Caputo, E, additional, Coviello, E, additional, Galasso, R, additional, Citarella, A, additional, Sampietro, G, additional, Magoni, M, additional, Ardizzone, A, additional, D’Argenzio, A, additional, Sutera Sardo, A, additional, Giorno, A, additional, La Greca, G, additional, Ricci, P, additional, Ferretti, S, additional, Palma, F, additional, Serraino, D, additional, Iacovacci, S, additional, Melcarne, A, additional, Puppo, A, additional, Sciacca, S, additional, Russo, AG, additional, Caruso, Bianca, additional, Cavalieri d’Oro, L, additional, D’Orsi, G, additional, Fusco, M, additional, Usala, M, additional, Vitale, F, additional, Cusimano, R, additional, Michiara, M, additional, Boschetti, L, additional, Chiaranda, G, additional, Rosso, S, additional, Tumino, R, additional, Mangone, L, additional, Valenti Clemente, S, additional, Falcini, F, additional, Caiazzo, AL, additional, Cesaraccio, R, additional, Tisano, F, additional, Fanetti, AC, additional, Minerba, S, additional, Caldarella, A, additional, Candela, G, additional, Piffer, S, additional, Cania, A, additional, Castelli, M, additional, Pisani, M, additional, Tagliabue, G, additional, Bovo, E, additional, and Brustolin, A, additional
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- 2019
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48. Trends of colorectal cancer incidence and mortality rates from 2003 to 2014 in Italy
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Zorzi, Manuel, primary, Dal Maso, Luigino, additional, Francisci, Silvia, additional, Buzzoni, Carlotta, additional, Rugge, Massimo, additional, Guzzinati, Stefano, additional, Mazzoleni, G., additional, Coviello, E., additional, Galasso, R., additional, Sampietro, G., additional, Magoni, M., additional, Ardizzone, A., additional, D‘Argenzio, A., additional, Sutera Sardo, A., additional, Giorno, A., additional, La Greca, G., additional, Ricci, P., additional, Ferretti, S., additional, Palma, F., additional, Serraino, D., additional, Iacovacci, S., additional, Melcarne, A., additional, Puppo, A., additional, Sciacca, S., additional, Russo, A.G., additional, Caruso, B., additional, Cavalieri d’Oro, L., additional, D‘Orsi, G., additional, Fusco, M., additional, Usala, M., additional, Vitale, F., additional, Cusimano, R., additional, Michiara, M., additional, Boschetti, L., additional, Chiaranda, G., additional, Rosso, S., additional, Tumino, R., additional, Mangone, L., additional, Falcini, F., additional, Caiazzo, A.L., additional, Cesaraccio, R., additional, Tisano, F., additional, Fanetti, A.C., additional, Minerba, S., additional, Caldarella, A., additional, Candela, G., additional, Piffer, S., additional, Cania, A., additional, Castelli, M., additional, Pisani, M., additional, Tagliabue, G., additional, Bovo, E., additional, and Brustolin, A., additional
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- 2019
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49. The impact of psychomotor subtypes and duration of delirium on 6-month mortality in hip-fractured elderly patients
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Bellelli, G, Carnevali, L, Corsi, M, Morandi, A, Zambon, A, Mazzola, P, Galeazzi, M, Bonfanti, A, Massariello, F, Szabo, H, Oliveri, G, Haas, J, D'Oro, L, Annoni, G, Bellelli, Giuseppe, Carnevali, Lucio, Corsi, Maurizio, Morandi, Alessandro, Zambon, Antonella, Mazzola, Paolo, Galeazzi, Marianna, BONFANTI, ALESSANDRA MARIA, MASSARIELLO, FRANCESCA, Szabo, Hajnalka, OLIVERI, GIULIA, Haas, Justin, d'Oro, Luca Cavalieri, Annoni, Giorgio, Bellelli, G, Carnevali, L, Corsi, M, Morandi, A, Zambon, A, Mazzola, P, Galeazzi, M, Bonfanti, A, Massariello, F, Szabo, H, Oliveri, G, Haas, J, D'Oro, L, Annoni, G, Bellelli, Giuseppe, Carnevali, Lucio, Corsi, Maurizio, Morandi, Alessandro, Zambon, Antonella, Mazzola, Paolo, Galeazzi, Marianna, BONFANTI, ALESSANDRA MARIA, MASSARIELLO, FRANCESCA, Szabo, Hajnalka, OLIVERI, GIULIA, Haas, Justin, d'Oro, Luca Cavalieri, and Annoni, Giorgio
- Abstract
OBJECTIVE: Studies exploring the incidence and impact of the psychomotor subtypes of postoperative delirium (POD) on the survival of hip fracture patients are few, and results are inconsistent. We sought to assess the incidence of POD subtypes and their impact, in addition to delirium duration, on 6-month mortality in older patients after hip-fracture surgery. METHODS: This is a prospective study involving 571 individuals admitted to an Orthogeriatric Unit within a 5-year period with a diagnosis of hip fracture. Survival status was assessed 6 months after posthip fracture surgery. Postoperative delirium was diagnosed using the Diagnostic and Statistical Manual of Mental Disorders. Postoperative delirium subtypes were classified according to Lipowski's criteria. Cox regressions were used to evaluate the associations between POD subtypes, POD duration, and 6-month mortality, adjusting for covariates. RESULTS: The incidence of psychomotor POD subtypes was hypoactive 57 (10.0%), hyperactive 84 (14.7%), and mixed 79 (13.8%). Six-month mortality rates were 8.3%, 10.7%, 36.8%, and 29.1% in the no-delirium, hyperactive, hypoactive, and mixed-delirium subgroups, respectively. In adjusted models, the hypoactive subgroup (Hazard Ratio, HR = 3.14, 95% Confidence Intervals, CI, 1.63-6.04) and mixed subgroup (HR = 2.89, 95% CI, 1.49-5.62) showed high mortality rates and a significantly increased risk of mortality associated with POD duration as well. CONCLUSIONS: Hyperactive delirium was the most common POD psychomotor subtype, but hypoactive and mixed POD were associated with 6-month mortality risk. Moreover, the risk of death 6 months after surgery increased for both subgroups (hypoactive and mixed) with increasing duration of POD
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- 2018
50. Development and first application of an audit system for screening programs based on the PRECEDE-PROCEED model: an experience with breast cancer screening in the region of Lombardy (Italy).
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Cereda, Danilo, Federici, Antonio, Guarino, Angela, Serantoni, Grazia, Gruppo PRECEDE-PROCEED, Bastiampillai, J. A., Gabrielli, E., Grimaccia, F., Tessandri, L., Schivardi, M., Crisetig, M., Bardelli, R., Gola, G., Anghinoni, E., Bozzeda, A., Gotti, S., D'Oro, L. Cavalieri, Ilardo, A., Moretti, G., and Lobuono, F.
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BREAST cancer ,EARLY detection of cancer ,MEDICAL cooperation ,COMPUTER software ,AUDIT cycles - Abstract
Background: High participation and performance are necessary conditions for the effectiveness of breast cancer screening programs. Here we describe the process to define and test a planning software application and an audit cycle based on the PRECEDE-PROCEED model applied to improving breast cancer screening. We developed a planning software application following the phases of the PRECEDE-PROCEED model. The application was co-designed by local cancer screening program coordinators. An audit model was also developed. The revised application and the audit model were tested by all the coordinators of 15 breast cancer screening programs in the region of Lombardy in a 3-day workshop. The project plans produced using the application were compared with those produced in the previous year for clarity and completeness.Results: The 9 phases of the PRECEDE-PROCEED model were adapted to screening as follows: 1) identification of program goals (i.e., participation, sensitivity, false positive); 2) epidemiological issues; 3) best practices analysis; 4) evidence-based actions to be implemented in the screening center and the relationships with partners and stakeholders; 5) priority setting and identification of solutions for each issue; 6) definition of indicators; 7) monitoring; 8) evaluation; 9) impact assessment. The application automatically generated reports for each phase. During the audit cycle, the regional health authority negotiated the targets to be reached with local authorities and collected the improvement plans generated by the application. The plans produced after the application was adopted were more standardized and had clearer indicators for monitoring and evaluation compared to those produced in the previous year.Conclusions: The software application helps standardize criteria for planning interventions to improve screening programs and facilitates the implementation of the audit cycle. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
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