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2-s2.0-85103080083 Aim: Acute rheumatic fever (ARF) is the most common cause of acquired heart disease especially in developing countries. This study is intended to evaluate the relationship between severity of cardiac involvement and hematological parameters in children diagnosed with carditis at the first episode of ARF. Methods: In this study, 45 children with carditis at the first episode of ARF and 30 healthy children of the same age and gender, between September 2015 and February 2019, were retrospectively reviewed. The data of the patients were recorded from the hospital automation system. Patients with acute rheumatic carditis (ARC) were grouped into two as mild (n=30) and moderate-severe ARC (n=15). Hemoglobin, red blood cell distribution width (RDW), leukocyte, neutrophil, monocyte, lymphocyte, platelet counts, neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte ratio (MLR) were compared between control and all carditis patients, mild and moderate-severe carditis. Results: In ARC patients, hemoglobin and RDW values were statistically significantly lower (p

Background. Cerebral sinovenous thrombosis (CSVT) in children is a rare and life-threatening cerebrovascular disease. Hence, we evaluated its clinical presentations, inherited and acquired prothrombotic risk factors along with the accompanying diseases, the thrombosis locations as well as the outcomes of anticoagulant therapy in children with CSVT. Methods. The medical records of pediatric CSVT patients treated between January 2011 and September 2018 were analyzed retrospectively. Results. The study included 29 children, 15 boys (51.7%) and 14 girls (48.3%), with the median age being 11 years (range:3 days-17 years). The most commonly presented complaint in neonates was seizures and in the non-neonatal age groups was a headache. Also, at least one acquired and/or inherited thrombophilic risk factor was identified in 89.7% of the patients. The most commonly acquired prothrombotic risk factors along with the accompanying diseases included infections, central venous catheter, and dehydration, while the most commonly inherited thrombophilic risk factors included heterozygous factor-V Leiden mutation and elevated lipoprotein (a). The most common thrombosis location was found to be the transverse sinus. Also, none of the patients died due to the thrombotic episode. Complications included epilepsy in five patients, hydrocephalus in one patient, and intracranial hypertension in another patient. Conclusions. Clinicians need to be well aware of the inherited and acquired prothrombotic risk factors in CSVT. It should also be kept in mind that at-risk patients may also present with nonspecific signs and symptoms with no apparent neurological manifestation. The risk of acute complications and long-term sequelae can be substantially reduced if diagnosed early and initiated with appropriate treatment at the early stages.

Objectives: the aim of this study is to identify the epidemiological, clinical, and laboratory features of coronavirus disease 2019 (COVID-19) in children.Methods: a retrospective study was conducted by pediatric infectious disease specialists from 32 different hospitals from all over Turkey by case record forms. Pediatric cases who were diagnosed as COVID-19 between March 16, 2020, and June 15, 2020 were included. Case characteristics including age, sex, dates of disease onset and diagnosis, family, and contact information were recorded. Clinical data, including the duration and severity of symptoms, were also collected. Laboratory parameters like biochemical tests and complete blood count, chest X-ray, and chest computed tomography (CT) were determined. Results: there were 1,156 confirmed pediatric COVID-19 cases. In total, male cases constituted 50.3% (n = 582) and females constituted 49.7% (n = 574). The median age of the confirmed cases was 10.75 years (4.5-14.6). Of the total cases, 90 were younger than 1 year of age (7.8%), 108 were 1-3 years of age (9.3%), 148 were 3-6 years of age (12.8%), 298 were 6-12 years of age (25.8%), 233 were 12-15 years of age (20.2%), and 268 cases were older than 15 years of age (23.2%). The most common symptom of the patients at the first visit was fever (50.4%) (n = 583) for a median of 2 days (IQR: 1-3 days). Fever was median at 38.4 degrees C (38.0-38.7 degrees C). The second most common symptom was cough (n = 543, 46.9%). The other common symptoms were sore throat (n = 143, 12.4%), myalgia (n = 141, 12.2%), dyspnea (n = 118, 10.2%), diarrhea (n = 112, 9.7%), stomachache (n = 71, 6.1%), and nasal discharge (n = 63, 5.4%). When patients were classified according to disease severity, 263 (22.7%) patients were asymptomatic, 668 (57.7%) patients had mild disease, 209 (18.1%) had moderate disease, and 16 (1.5%) cases had severe disease. One hundred and forty-nine (12.9%) cases had underlying diseases among the total cases; 56% of the patients who had severe disease had an underlying condition (p < 0.01). The need for hospitalization did not differ between patients who had an underlying condition and those who do not have (p = 0.38), but the need for intensive care was higher in patients who had an underlying condition (p < 0.01). Forty-seven (31.5%) of the cases having underlying conditions had asthma or lung disease (38 of them had asthma). Conclusions: to the best of our knowledge, this is one of the largest pediatric data about confirmed COVID-19 cases. Children from all ages appear to be susceptible to COVID-19, and there is a significant difference in symptomatology and laboratory findings by means of age distribution., NA

AMAÇ: Çin’in Wuhan kentinde 2019 yılı sonunda bildirilen koronavirüs 2 (SARS-CoV-2) salgını, şu anda 100’den fazla ülkenin etkilendiği, akut solunum yetmezliği ile giden bir tablodur. Çalışmamızda; COVID-19 pozitif hafif-orta şiddette kliniğe sahip çocukların hematolojik bulgularının değerlendirilmesi ve bu hastalığı öngörmede çeşitli hematolojik indekslerin - lökosit, nötrofil, monosit, lenfosit ve trombosit sayıları, nötrofil/lenfosit oranı (NLR) and platelet/lenfosit oranı (PLR), monosit/lenfosit oranı (MLR)- diagnostik rolü araştılmıştır.GEREÇ VE YÖNTEM: Çalışmaya nazofarengeal sürüntü örneklerinden RT-PCR ile COVID-19 tanısı konulan 15 çocuk ile benzer yaş ve cinsiyette 21 sağlıklı çocuktan oluşan kontrol grubu alındı. Hastaların dosya bilgilerinden retrospektif olarak yaşları, cinsiyetleri, başvuru şikayetleri, COVID-19 temas öyküsü, başvurularında alınan ilk tam kan sayımı parametreleri kayıt edildi.BULGULAR: COVID-19 tanısı konulan çocukların yaşları (median±SD) 8.7±5.7 yıl ve kız/erkek oranı 8/7, sağlıklı kontrol grubunun yaşları (median±SD) 7.4±2.8 yıl ve kız/erkek oranı 11/10 idi. COVID-19 testi pozitif saptanan hastaların en sık başvuru şikayeti ateş ve öksürüktü. COVID-19 pozitif çocuklarla sağlıklı kontrol grup arasında nötrofil, lenfosit ve NLR arasında istatistiksel anlamlı fark tespit edildi (p=0.048, p=0.040, p =0.024, sırasıyla). ROC analizinde, NLR için kestirim değeri 1.02 alındığında eğri altındaki alan (AUC) of 0.724, %95 CI (0,549-0,899), sensivite %73, spesifite %62 olarak çocuklarda COVID-19 tanısını predikte etmektedir.SONUÇ: COVID-19 tanılı çocukların hematolojik parametre ve indekslerinde sağlıklı kontrollere göre anormallikler tespit edilmiştir. Bunlardan en belirgin olanları lenfopeni ve NLR oranında artıştır. Periferik kan parametrelerinin değerlendirilmesinin COVID-19'un prognozunu değerlendirmesinde önemli referans değer olarak değerlendirilebileceğini düşünmekteyiz, OBJECTIVE: The coronavirus-2 (SARS-CoV-2) outbreak, reported in Wuhan, China at the end of 2019, has a clinical picture with acute respiratory failure, currently affecting more than 100 countries. In our study, evaluation of hematological findings of children with COVID-19 positive mild-moderate clinic was performed and the diagnostic role of various hematological indices-leukocyte, neutrophil, monocyte, lymphocyte and platelet counts, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR)- was examined.MATERIAL AND METHODS: The study included 15 children diagnosed with COVID-19 from nasopharyngeal swab samples by RT-PCR, and a control group of 21 healthy children of similar age and sex. The patients' age, gender, admission complaints, COVID-19 contact history, and first complete blood count parameters were recorded retrospectively from information of the patient files.RESULTS: The ages of the children diagnosed with COVID-19 (median±SD) were 8.7±5.7 years and the female/male ratio was 8/7, the healthy control group's age (median±SD) was 7.4±2.8 years, and the female/male ratio was 11/10. The most common complaints of patients with positive COVID-19 tests were fever and cough. A statistically significant difference was found between neutrophil, lymphocyte, and NLR between the COVID-19 positive children and the healthy control group (p=0.048, p=0.040, p=0.024, respectively). In the ROC analysis, when the predictive value for NLR is taken as 1.02, it predicts area under the curve (AUC) of 0.724, 95%CI (0.549-0.899), sensitivity 73%, specificity 62% for the diagnosis of COVID-19 in children.CONCLUSIONS: Abnormalities were detected in hematological parameters and indexes of children diagnosed with COVID-19 compared to healthy controls. The most prominent of these are lymphopenia and an increase in the NLR rate. We think that the evaluation of peripheral blood parameters can be considered as an important reference value in evaluating the prognosis of COVID-19.