93 results on '"Dölle S"'
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2. Gelebte Interdisziplinarität: das Comprehensive Allergy Center der Charité (CACC) – Versorgung allergischer Patient/-innen im Kindes-, Jugend- und Erwachsenenalter
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Fluhr, J.W., primary, Zuberbier, T., additional, Pleyer, U., additional, Lau, S., additional, Fischer, A., additional, Olze, H., additional, Herzog, L., additional, Worm, M., additional, Dölle, S., additional, Maurer, M., additional, Metz, M., additional, Wolfahrt, B., additional, and Förster-Ruhrmann, U., additional
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- 2022
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3. Das Comprehensive Allergy Center der Charité (CACC) - Versorgung allergischer Patient/-innen im Kindes-, Jugend- und Erwachsenenalter
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Fluhr, J.W., Zuberbier, Torsten, Pleyer, U., Lau, S., Fischer, A., Olze, H., Herzog, Leonie, Worm, M., Dölle, S., Maurer, Marcus, Metz, Martin, Wolfahrt, B., Förster-Ruhrmann, U., and Publica
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certification ,interdisciplinarity ,continuing medical education (CME) ,Comprehensive Allergy Center ,allergy - Abstract
In den Jahren ab 2010 wurde in Anlehnung an die Comprehensive Cancer ein erweiterter Kriterienkatalog unter Einschluss der bereits bekannten GA2LEN-Kriterien für die Allergiezentren erarbeitet. Im Rahmen dieser Initiative wurde die Charité 2014 als erstes Zentrum zertifiziert. Eine Rezertifizierung fand in den Jahren 2018 und 2020 statt. Dem CACC gehören derzeit folgende Fachrichtungen an: Arbeitsmedizin, Augenheilkunde, Dermatologie, Hals-Nasen-Ohren-Heilkunde, Pädiatrie, Pneumologie, Sportmedizin und das Institut für Allergieforschung. Unsere zentralen Ziele als CACC sind eine optimale Patientenversorgung auf wissenschaftlich höchstem Niveau, sowie eine interdisziplinäre Aus- und Weiterbildung auf dem Gebiet der Allergologie. Um unsere Patientenversorgung stets zu verbessern und neue Erkenntnisgewinne für allergologische Erkrankungen zu generieren, verfolgen wir eine Vielzahl gemeinsamer Forschungsanstrengungen. Durch unsere Publikationen, Medienauftritte und Fachveranstaltungen erreichen wir eine deutlich bessere Wahrnehmung bei Patienten und in Fachkreisen.
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- 2022
4. Nahrungsmittelassoziierte Anaphylaxie: Daten aus dem Anaphylaxie-Register
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Dölle, S., Hompes, S., Grünhagen, J., and Worm, M.
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- 2012
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5. Identification of putative new tomato allergens and differential interaction with IgEs of tomato allergic subjects
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Welter, S., Lehmann, K., Dölle, S., Schwarz, D., Weckwerth, W., Scheler, C., Worm, M., and Franken, P.
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- 2013
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6. Allergenic activity of different tomato cultivars in tomato allergic subjects
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Dölle, S., Lehmann, K., Schwarz, D., Weckwert, W., Scheler, C., George, E., Franken, P., and Worm, M.
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- 2011
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7. Einsatz molekularer Allergiediagnostik - intéressante Fallvorstellungen: WS11/05
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Dölle, S, Grünhagen, J, Hiepe, J, and Worm, M
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- 2011
8. Long-term reduction in local inflammation by a lipid raft molecule in atopic dermatitis
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Dölle, S., Hoser, D., Rasche, C., Loddenkemper, C., Maurer, M., Zuberbier, T., and Worm, M.
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- 2010
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9. Docosahexaenoic acid (DHA) supplementation in atopic eczema: a randomized, double-blind, controlled trial
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Koch, C., Dölle, S., Metzger, M., Rasche, C., Jungclas, H., Rühl, R., Renz, H., and Worm, M.
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- 2008
10. Epinephrine in Severe Allergic Reactions: The European Anaphylaxis Register
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Grabenhenrich, L.B. Dölle, S. Ruëff, F. Renaudin, J.-M. Scherer, K. Pföhler, C. Treudler, R. Koehli, A. Mahler, V. Spindler, T. Lange, L. Bilò, M.B. Papadopoulos, N.G. Hourihane, J.O.B. Lang, R. Fernández-Rivas, M. Christoff, G. Cichocka-Jarosz, E. Worm, M.
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Background: Current guidelines recommend intramuscular administration of epinephrine as the first-line drug for the emergency treatment of severe allergic reactions (anaphylaxis), but no randomized trial evidence supports this consensus. Objective: We aimed to assess anaphylaxis treatment practices over 10 years, covering several European regions, all allergen sources, and all age groups. Methods: The European Anaphylaxis Register tracks elicitors, symptoms, emergency treatment, diagnostic workups, and long-term counseling for anaphylaxis incidents through web-based data entry from tertiary allergy specialists, covering information from the emergency respondent, patient, tertiary referral, and laboratory/clinical test results. Results: We analyzed 10,184 anaphylaxis incidents. In total, 27.1% of patients treated by a health professional received epinephrine and, in total, 10.5% received a second dose. Successful administration was less frequent in German-speaking countries (minimum 19.6%) than in Greece, France, and Spain (maximum 66.7%). Over the last decade, epinephrine administration from a health professional almost doubled to reach 30.6% in 2015-2017, half of which was applied intramuscularly. A total of 14.7% of lay- or self-treated cases were treated with an autoinjector. Of those without treatment, 22.4% carried a device for administration. No change in successful administration by lay emergency respondents was found over the last 10 years. Of the reaction and patient characteristics analyzed, only clinical severity considerably influenced the likelihood of receiving epinephrine, with 66.9% of successful administrations in near-fatal (grade IV) reactions. Conclusions: Despite clear recommendations, only a small proportion of anaphylaxis incidents are treated with epinephrine. We demonstrated a slight increase in treated patients when handled by professionals, but stagnation in lay- or self-treated anaphylaxis. The reaction circumstances, the respondent's professional background, and patient characteristics did not explain which reactions were treated. © 2018 American Academy of Allergy, Asthma & Immunology
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- 2018
11. Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry
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Worm, M. Francuzik, W. Renaudin, J.-M. Bilo, M.B. Cardona, V. Scherer Hofmeier, K. Köhli, A. Bauer, A. Christoff, G. Cichocka-Jarosz, E. Hawranek, T. Hourihane, J.O.B. Lange, L. Mahler, V. Muraro, A. Papadopoulos, N.G. Pföhler, C. Poziomkowska-Gęsicka, I. Ruëff, F. Spindler, T. Treudler, R. Fernandez-Rivas, M. Dölle, S.
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Background: Preventive measures to decrease the frequency and intensity of anaphylactic events are essential to provide optimal care for allergic patients. Aggravating factors may trigger or increase the severity of anaphylaxis and therefore need to be recognized and avoided. Objective: To identify and prioritize factors associated with an increased risk of developing severe anaphylaxis. Methods: Data from the Anaphylaxis Registry (122 centers in 11 European countries) were used in logistic regression models considering existing severity grading systems, elicitors, and symptoms to identify the relative risk of factors on the severity of anaphylaxis. Results: We identified higher age and concomitant mastocytosis (OR: 3.1, CI: 2.6-3.7) as the most important predictors for an increased risk of severe anaphylaxis. Vigorous physical exercise (OR: 1.5, CI: 1.3-1.7), male sex (OR: 1.2, CI: 1.1-1.3), and psychological burden (OR: 1.4, CI: 1.2-1.6) were more often associated with severe reactions. Additionally, intake of beta-blockers (OR: 1.9, CI: 1.5-2.2) and ACE-I (OR: 1.28, CI: 1.05, 1.51) in temporal proximity to allergen exposition was identified as an important factor in logistic regression analysis. Conclusion: Our data suggest it may be possible to identify patients who require intensified preventive measures due to their relatively higher risk for severe anaphylaxis by considering endogenous and exogenous factors. © 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
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- 2018
12. Nicht-Zöliakie-Gluten-/Weizen-Sensitivität (NCGS) – ein bislang nicht definiertes Krankheitsbild mit fehlenden Diagnosekriterien und unbekannter Häufigkeit
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Reese, I., primary, Schäfer, C., additional, Tebbe, J. Kleine-, additional, Ahrens, B., additional, Bachmann, O., additional, Ballmer-Weber, B., additional, Beyer, K., additional, Bischoff, S.C., additional, Blümchen, K., additional, Dölle, S., additional, Enck, P., additional, Enninger, A., additional, Huttegger, I., additional, Lämmel, S., additional, Lange, L., additional, Lepp, U., additional, Mahler, V., additional, Mönnikes, H., additional, Ockenga, J., additional, Otto, B., additional, Schnadt, S., additional, Szepfalusi, Z., additional, Treudler, R., additional, Wassmann-Otto, A., additional, Zuberbier, T., additional, Werfel, T., additional, and Worm, M., additional
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- 2019
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13. Diätetische Implikationen: Salicylsäure und ASS-Unverträglichkeit
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Plank-Habibi, S., primary, Dölle, S., additional, and Schäfer, C., additional
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- 2018
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14. Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry
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Worm, M., primary, Francuzik, W., additional, Renaudin, J.‐M., additional, Bilo, M. B., additional, Cardona, V., additional, Scherer Hofmeier, K., additional, Köhli, A., additional, Bauer, A., additional, Christoff, G., additional, Cichocka‐Jarosz, E., additional, Hawranek, T., additional, Hourihane, J. O.’B., additional, Lange, L., additional, Mahler, V., additional, Muraro, A., additional, Papadopoulos, N. G., additional, Pföhler, C., additional, Poziomkowska‐Gęsicka, I., additional, Ruëff, F., additional, Spindler, T., additional, Treudler, R., additional, Fernandez‐Rivas, M., additional, and Dölle, S., additional
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- 2018
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15. Clinical reactivity of celery cultivars in allergic patients: Role of Api g 1
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Dölle, S., primary, Welter, S., additional, Ruppel, E., additional, Lehmann, K., additional, Schwarz, D., additional, Jensen-Jarolim, E., additional, Zieglmayer, P., additional, Franken, P., additional, and Worm, M., additional
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- 2018
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16. Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
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Pouessel, G, Claverie, C, Labreuche, J, Renaudin, J-M, Dorkenoo, A, Eb, M, Moneret-Vautrin, A, Deschildre, A, Leteurtre, S, Grabenhenrich, L, Worm, M, Dölle, S, Scherer, K, Hutteger, I, Christensen, M, Bindslev-Jensen, C, Mortz, C, Eller, E, Kjaer, HF, Carneiro-Leão, L, Badas, J, Coimbra, A, Levy, DP, Ben-Shoshan, M, Rimon, A, Benor, S, Arends, NJT, Edelbroek, N, de Groot, H, Emons, JAM, Brand, HKA, Verhoeven, D, van Veen, LN, de Jong, NW, Noh, G, Jang, EH, Pascal, M, Dominguez, O, Piquer, M, Alvaro, M, Jimenez-Feijoo, R, Lozano, J, Machinena, A, del Mar Folqué, M, Giner, MT, Plaza, AM, Turner, P, Patel, N, Vazquez-Ortiz, M, Lindsley, S, Walker, L, Rosenberg, S, Mari, A, Alessandri, C, Giangrieco, I, Tuppo, L, Rafaiani, C, Mitterer, G, Ciancamerla, M, Ferrara, R, Bernardi, ML, Zennaro, D, Tamburrini, M, Ciardiello, MA, Harwanegg, C, Fernandez, A, Selb, R, Egenmann, P, Epstein, M, Hoffmann-Sommergruber, K, Koning, F, Lovik, M, Clare Mills, EN, Moreno, J, van Loveren, H, Wal, J-M, Diesner, S, Bergmayr, C, Pfitzner, B, Assmann, VE, Starkl, P, Endesfelder, D, Eiwegger, T, Szepfalusi, Z, Fehrenbach, H, Jensen-Jarolim, E, Hartmann, A, Pali-Schöll, I, Untersmayr, E, Wille, S, Meyer, P, Klingebiel, C, Lidholm, J, Ehrenberg, A, Östling, J, Cleach, I, Mège, J-L, Vitte, J, Aina, R, Dubiela, P, Pfeifer, S, Bublin, M, Radauer, C, Humeniuk, P, Kabasser, S, Asero, R, Bogas, G, Gomez, F, Campo, P, Salas, M, Doña, I, Barrionuevo, E, Guerrero, MA, Mayorga, C, Prieto, A, Barber, D, Torres, MJ, Jamin, A, Wangorsch, A, Ballmer, B, Vieths, S, Scheurer, S, Apostolovic, D, Mihailovic, J, Krstic, M, Starkhammar, M, Velickovic, TC, Hamsten, C, van Hage, M, van Erp, FC, Knol, EF, Kansen, HM, Pontoppidan, B, Meijer, Y, van der Ent, CK, Knulst, AC, Sayers, R, Brown, H, Custovic, A, Simpson, A, Mills, C, Schulz, J, Akkerdaas, J, Totis, M, Capt, A, Herouet-Guicheney, C, van Ree, R, Banerjee, T, Banerjee, A, Claude, M, Bouchaud, G, Lupi, R, Castan, L, Tranquet, O, Denery-Papini, S, Bodinier, M, Brossard, C, De Poi, R, Gritti, E, De Dominicis, E, Popping, B, de Laureto, PP, Palosuo, K, Kukkonen, AK, Pelkonen, A, Mäkelä, M, Lee, NA, Rost, J, Muralidharan, S, Campbell, D, Mehr, S, Nock, C, Baumert, J, Taylor, S, Mastrorilli, C, Tripodi, S, Caffarelli, C, Perna, S, Di Rienzo Businco, A, Sfika, I, Dondi, A, Bianchi, A, Dascola, CP, Ricci, G, Cipriani, F, Maiello, N, del Giudice, MM, Frediani, T, Frediani, S, Macrì, F, Pistoletti, C, Iacono, ID, Patria, MF, Varin, E, Peroni, D, Comberiati, P, Chini, L, Moschese, V, Lucarelli, S, Bernardini, R, Pingitore, G, Pelosi, U, Olcese, R, Moretti, M, Cirisano, A, Faggian, D, Travaglini, A, Plebani, M, Verga, MC, Calvani, M, Giordani, P, Matricardi, PM, Ontiveros, N, Cabrera-Chavez, F, Galand, J, Beaudouin, E, Pineau, F, Sakai, S, Matsunaga, K, Teshima, R, Larré, C, Denery, S, Tschirner, S, Trendelenburg, V, Schulz, G, Niggemann, B, Beyer, K, Bouferkas, Y, Belabbas, Y, Saidi, D, Kheroua, O, Mecherfi, KEE, Guendouz, M, Haddi, A, Kaddouri, H, Amaral, L, Pereira, A, Rodrigues, S, Datema, M, Jongejan, L, Clausen, M, Knulst, A, Papadopoulos, N, Kowalski, M, de Blay, F, Zwinderman, A, Hoffman-Sommergruber, K, Ballmer-Weber, B, Fernandez-Rivas, M, Deng, S, Yin, J, Eisenmann, C, Nassiri, M, Reinert, R, van der Valk, JPM, van Wijk, RG, Vergouwe, Y, Steyerberg, EW, Reitsma, M, Wichers, HJ, Savelkoul, HFJ, Vlieg-Boerstra, B, Dubois, AEJ, Carolino, F, Rodolfo, A, Cernadas, J, Roa-Medellín, D, Rodriguez-Fernandez, A, Navarro, J, Albendiz, V, Baeza, ML, Intente-Herrero, S, Mikkelsen, A, Mehlig, K, Lissner, L, Verrill, L, Luccioli, S, van Bilsen, J, Kuper, F, Wolterbeek, A, Rankouhi, TR, Verschuren, L, Cnossen, H, Jeurink, P, Garssen, J, Knippels, L, Garthoff, J, Houben, G, Leeman, W, Eleonore Pettersson, M, Schins, AMM, Koppelman, GH, Kollen, BJ, Zubchenko, S, Kuntz, S, Mérida, P, Álvaro, M, Riggioni, C, Castellanos, JH, Jimenez, R, Cap, M, Drumez, E, Lejeune, S, Thumerelle, C, Mordacq, C, Nève, V, Ricò, S, Varini, M, Nocerino, R, Cosenza, L, Amoroso, A, Di Costanzo, M, Di Scala, C, Bedogni, G, Canani, RB, Turner, PJ, Poza-Guedes, P, González-Pérez, R, Sánchez-Machín, I, Matheu-Delgado, V, Wambre, E, Ballegaard, A-S, Madsen, C, Gregersen, J, Bøgh, KL, Aubert, P, Neunlist, M, Magnan, A, Lozano-Ojalvo, D, Pablos-Tanarro, A, Pérez-Rodríguez, L, Molina, E, López-Fandiño, R, Rekima, A, Macchiaverni, P, Turfkruyer, M, Holvoet, S, Dupuis, L, Baiz, N, Annesi-Maesano, I, Mercenier, A, Nutten, S, Verhasselt, V, Mrakovcic-Sutic, I, Banac, S, Sutic, I, Baricev-Novakovic, Z, Pavisic, V, Muñoz-Cano, R, Jiménez-Rodríguez, T, Corbacho, D, Roca-Ferrer, J, Bartra, J, Bulog, A, Micovic, V, Markiewicz, L, Szymkiewicz, A, Szyc, A, Wróblewska, B, Harvey, BM, Harthoorn, LF, Wesley Burks, A, Rentzos, G, Björk, A-LB, Bengtsson, U, Barber, C, Kalicinsky, C, Breynaert, C, Coorevits, L, Jansen, C, Van Hoeyveld, E, Verbeke, K, Kochuyt, A-M, Schrijvers, R, Deleanu, D, Muntean, A, Konstantakopoulou, M, Pasioti, M, Papadopoulou, A, Iliopoulou, A, Mikos, N, Kompoti, E, de Castro, ED, Bartalomé, B, Ue, KL, Griffiths, E, Till, S, Grimshaw, K, Roberts, G, Selby, A, Butiene, I, Larco, JI, Dubakiene, R, Fiandor, A, Fiocchi, A, Sigurdardottir, S, Sprikkelman, A, Schoemaker, A-F, Xepapadaki, P, Keil, T, Cojocariu, Z, Barbado, BS, Iancu, V, Arroabarren, E, Esarte, MG, Arteaga, M, Andrade, MC, Borges, D, Kalil, J, Bianchi, PG, Agondi, RC, Gupta, RK, Sharma, A, Gupta, K, Das, M, Dwivedi, P, Karseladze, R, Jorjoliani, L, Saginadze, L, Tskhakaia, M, Basello, K, Piuri, G, Speciani, AF, Speciani, MC, Camerotto, C, Zinno, F, Pakholchuk, O, Nedelska, S, Pattini, S, Costantino, MT, Peveri, S, Villalta, D, Savi, E, Costanzi, A, Revyakina, VA, Kiseleva, MA, Kuvshinova, ED, Larkova, IA, Shekhetov, AA, Silva, D, Moreira, A, Plácido, J, van der Kleij, H, van Twuijver, E, Sutorius, R, de Kam, P-J, van Odijk, J, Lindqvist, H, Lustig, E, Jácome, AAA, Aguilar, KLB, Domínguez, MG, Hernández, DAM, Caruso, C, Casale, C, Rapaccini, GL, Romano, A, De Vitis, I, Cocco, RR, Aranda, C, Mallozi, MC, Motta, JF, Moraes, L, Pastorino, A, Rosario, N, Goudouris, E, Porto, A, Wandalsen, NF, Sarinho, E, Sano, F, Solé, D, Pitsios, C, Petrodimopoulou, M, Papadopoulou, E, Passioti, M, Kontogianni, M, Adamia, N, Khaleva, E, del Prado, AP, Du Toit, G, Krzych, E, Samolinska-Zawisza, U, Furmanczyk, K, Tomaszewska, A, Raciborski, F, Lipiec, A, Samel-Kowalik, P, Walkiewicz, A, Borowicz, J, Samolinski, B, Nano, AL, Recto, M, Somoza, ML, López, NB, Alzate, DP, Ruano, FJ, Garcimartín, MI, Haroun, E, de la Torre, MV, Rojas, A, Onieva, ML, Canto, G, Rodrigues, A, Forno, A, Cabral, AJ, Gonçalves, R, Vorozhko, I, Sentsova, T, Chernyak, O, Denisova, S, Ilènko, L, Muhortnich, V, Zimmermann, C, Rohrbach, A, Bakhsh, FR, Boudewijn, K, Oomkes-Pilon, A-M, Van Ginkle, D, Šilar, M, Jeverica, A, Vesel, T, Avčin, T, Korošec, P, van der Valk, J, Berends, I, Arends, N, van Maaren, M, Wichers, H, Emons, J, Dubois, A, de Jong, N, Matsyura, O, Besh, L, Huang, C-H, Jan, T-R, Stiefel, G, Tratt, J, Kirk, K, Arasi, S, Caminiti, L, Crisafulli, G, Fiamingo, C, Fresta, J, Pajno, G, Remington, B, Kruizinga, A, Marty Blom, W, Westerhout, J, Bijlsma, S, Blankestijn, M, Otten, H, Klemans, R, Michelsen-Huisman, AD, van Os-Medendorp, H, Kruizinga, AG, Versluis, A, van Duijn, G, de Zeeuw-Brouwer, HM-L, Castenmiller, JJM, Noteborn, HPJM, Houben, GF, Bravin, K, Luyt, D, Javed, B, Couch, P, Munro, C, Padfield, P, Sperrin, M, Byrne, A, Oosthuizen, L, Kelleher, C, Ward, F, Brosnan, N, King, G, Corbet, E, Guzmán, JAH, García, MB, Asensio, O, Navarrete, LV, Larramona, H, Miró, XD, Pyrz, K, Austin, M, Boloh, Y, Galloway, D, Hernandez, P, Hourihane, JOB, Kenna, F, Majkowska-Wojciechowska, B, Regent, L, Themisb, M, Schnadt, S, Semic-Jusufagic, A, Galvin, AD, Kauppila, T, Kuitunen, M, Kitsioulis, NA, Douladiris, N, Kostoudi, S, Manolaraki, I, Mitsias, D, Manousakis, E, Papadopoulos, NG, Knibb, R, Hammond, J, Cooke, R, Yrjänä, J, Hanni, A-M, Vähäsarja, P, Mustonen, O, Dunder, T, Kulmala, P, Lasa, E, D’Amelio, C, Martínez, S, Joral, A, Gastaminza, G, Goikoetxea, MJ, Candy, DCA, Van Ampting, MTJ, Oude Nijhuis, MM, Butt, AM, Peroni, DG, Fox, AT, Knol, J, Michaelis, LJ, Padua, I, Padrao, P, Moreira, P, Barros, R, Sharif, H, Ahmed, M, Gomaa, N, Mens, J, Smit, K, Timmermans, F, Poredoš, T, Jeverica, AK, Sedmak, M, Benedik, E, Accetto, M, Zupančič, M, Yonamine, G, Soldateli, G, Aquilante, B, Pastorino, AC, de Moraes Beck, CL, Gushken, AK, de Barros Dorna, M, dos Santos, CN, Castro, APM, Al-Qahtani, A, Arnaout, R, Khaliq, AR, Amin, R, Sheikh, F, Alvarez, J, Anda, M, Palacios, M, De Prada, M, Ponce, C, Balbino, B, Sibilano, R, Marichal, T, Gaudenzio, N, Karasuyama, H, Bruhns, P, Tsai, M, Reber, LL, Galli, SJ, Ferreira, AR, Cernadas, JR, del Campo García, A, Fernández, SP, Carrera, NS, Sánchez-Cruz, FB, Lorenzo, JRF, Claus, S, Pföhler, C, Ruëff, F, Treudler, R, Jaume, ME, Madroñero, A, Perez, MTG, Julia, JC, Plovdiv, CH, Gethings, L, Langridge, J, Adel-Patient, K, Bernard, H, Barcievic-Jones, I, Sokolova, R, Yankova, R, Ivanovska, M, Murdjeva, M, Popova, T, Dermendzhiev, S, Karjalainen, M, Lehnigk, U, Brown, D, Locklear, JC, Locklear, J, Maris, I, Hourihane, J, Ornelas, C, Caiado, J, Ferreira, MB, Pereira-Barbosa, M, Puente, Y, Daza, JC, Monteseirin, FJ, Ukleja-Sokolowska, N, Gawronska-Ukleja, E, Zbikowska-Gotz, M, Bartuzi, Z, Sokolowski, L, Adams, A, Mahon, B, English, K, Gourdon-Dubois, N, Sellam, L, Pereira, B, Michaud, E, Messaoudi, K, Evrard, B, Fauquert, J-L, Palomares, F, Gomez, G, Rodriguez, MJ, Galindo, L, Molina, A, Paparo, L, Mennini, M, Aitoro, R, Wawrzeńczyk, A, Przybyszewski, M, Sarıcoban, HE, Ugras, M, Yalvac, Z, Flokstra-de Blok, BMJ, van der Velde, JL, Vereda, A, Ippolito, C, Traversa, A, Adriano, D, Bianchi, DM, Gallina, S, Decastelli, L, Makatsori, M, Miles, A, Devetak, SP, Devetak, I, Tabet, SA, Trandbohus, JF, Winther, P, Malling, H-J, Hansen, KS, Garvey, LH, Wang, C-C, Cheng, Y-H, Tung, C-W, Dietrich, M, Marenholz, I, Kalb, 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Thumerelle, C, Mordacq, C, Nève, V, Ricò, S, Varini, M, Nocerino, R, Cosenza, L, Amoroso, A, Di Costanzo, M, Di Scala, C, Bedogni, G, Canani, RB, Turner, PJ, Poza-Guedes, P, González-Pérez, R, Sánchez-Machín, I, Matheu-Delgado, V, Wambre, E, Ballegaard, A-S, Madsen, C, Gregersen, J, Bøgh, KL, Aubert, P, Neunlist, M, Magnan, A, Lozano-Ojalvo, D, Pablos-Tanarro, A, Pérez-Rodríguez, L, Molina, E, López-Fandiño, R, Rekima, A, Macchiaverni, P, Turfkruyer, M, Holvoet, S, Dupuis, L, Baiz, N, Annesi-Maesano, I, Mercenier, A, Nutten, S, Verhasselt, V, Mrakovcic-Sutic, I, Banac, S, Sutic, I, Baricev-Novakovic, Z, Pavisic, V, Muñoz-Cano, R, Jiménez-Rodríguez, T, Corbacho, D, Roca-Ferrer, J, Bartra, J, Bulog, A, Micovic, V, Markiewicz, L, Szymkiewicz, A, Szyc, A, Wróblewska, B, Harvey, BM, Harthoorn, LF, Wesley Burks, A, Rentzos, G, Björk, A-LB, Bengtsson, U, Barber, C, Kalicinsky, C, Breynaert, C, Coorevits, L, Jansen, C, Van Hoeyveld, E, Verbeke, K, Kochuyt, A-M, Schrijvers, R, Deleanu, D, 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MG, Hernández, DAM, Caruso, C, Casale, C, Rapaccini, GL, Romano, A, De Vitis, I, Cocco, RR, Aranda, C, Mallozi, MC, Motta, JF, Moraes, L, Pastorino, A, Rosario, N, Goudouris, E, Porto, A, Wandalsen, NF, Sarinho, E, Sano, F, Solé, D, Pitsios, C, Petrodimopoulou, M, Papadopoulou, E, Passioti, M, Kontogianni, M, Adamia, N, Khaleva, E, del Prado, AP, Du Toit, G, Krzych, E, Samolinska-Zawisza, U, Furmanczyk, K, Tomaszewska, A, Raciborski, F, Lipiec, A, Samel-Kowalik, P, Walkiewicz, A, Borowicz, J, Samolinski, B, Nano, AL, Recto, M, Somoza, ML, López, NB, Alzate, DP, Ruano, FJ, Garcimartín, MI, Haroun, E, de la Torre, MV, Rojas, A, Onieva, ML, Canto, G, Rodrigues, A, Forno, A, Cabral, AJ, Gonçalves, R, Vorozhko, I, Sentsova, T, Chernyak, O, Denisova, S, Ilènko, L, Muhortnich, V, Zimmermann, C, Rohrbach, A, Bakhsh, FR, Boudewijn, K, Oomkes-Pilon, A-M, Van Ginkle, D, Šilar, M, Jeverica, A, Vesel, T, Avčin, T, Korošec, P, van der Valk, J, Berends, I, Arends, N, van Maaren, M, Wichers, H, Emons, J, Dubois, A, de Jong, N, Matsyura, O, Besh, L, Huang, C-H, Jan, T-R, Stiefel, G, Tratt, J, Kirk, K, Arasi, S, Caminiti, L, Crisafulli, G, Fiamingo, C, Fresta, J, Pajno, G, Remington, B, Kruizinga, A, Marty Blom, W, Westerhout, J, Bijlsma, S, Blankestijn, M, Otten, H, Klemans, R, Michelsen-Huisman, AD, van Os-Medendorp, H, Kruizinga, AG, Versluis, A, van Duijn, G, de Zeeuw-Brouwer, HM-L, Castenmiller, JJM, Noteborn, HPJM, Houben, GF, Bravin, K, Luyt, D, Javed, B, Couch, P, Munro, C, Padfield, P, Sperrin, M, Byrne, A, Oosthuizen, L, Kelleher, C, Ward, F, Brosnan, N, King, G, Corbet, E, Guzmán, JAH, García, MB, Asensio, O, Navarrete, LV, Larramona, H, Miró, XD, Pyrz, K, Austin, M, Boloh, Y, Galloway, D, Hernandez, P, Hourihane, JOB, Kenna, F, Majkowska-Wojciechowska, B, Regent, L, Themisb, M, Schnadt, S, Semic-Jusufagic, A, Galvin, AD, Kauppila, T, Kuitunen, M, Kitsioulis, NA, Douladiris, N, Kostoudi, S, Manolaraki, I, Mitsias, D, Manousakis, E, Papadopoulos, NG, Knibb, R, Hammond, J, Cooke, R, Yrjänä, J, Hanni, A-M, Vähäsarja, P, Mustonen, O, Dunder, T, Kulmala, P, Lasa, E, D’Amelio, C, Martínez, S, Joral, A, Gastaminza, G, Goikoetxea, MJ, Candy, DCA, Van Ampting, MTJ, Oude Nijhuis, MM, Butt, AM, Peroni, DG, Fox, AT, Knol, J, Michaelis, LJ, Padua, I, Padrao, P, Moreira, P, Barros, R, Sharif, H, Ahmed, M, Gomaa, N, Mens, J, Smit, K, Timmermans, F, Poredoš, T, Jeverica, AK, Sedmak, M, Benedik, E, Accetto, M, Zupančič, M, Yonamine, G, Soldateli, G, Aquilante, B, Pastorino, AC, de Moraes Beck, CL, Gushken, AK, de Barros Dorna, M, dos Santos, CN, Castro, APM, Al-Qahtani, A, Arnaout, R, Khaliq, AR, Amin, R, Sheikh, F, Alvarez, J, Anda, M, Palacios, M, De Prada, M, Ponce, C, Balbino, B, Sibilano, R, Marichal, T, Gaudenzio, N, Karasuyama, H, Bruhns, P, Tsai, M, Reber, LL, Galli, SJ, Ferreira, AR, Cernadas, JR, del Campo García, A, Fernández, SP, Carrera, NS, Sánchez-Cruz, FB, Lorenzo, JRF, Claus, S, Pföhler, C, Ruëff, F, Treudler, R, Jaume, ME, Madroñero, A, Perez, MTG, Julia, JC, Plovdiv, CH, Gethings, L, Langridge, J, Adel-Patient, K, Bernard, H, Barcievic-Jones, I, Sokolova, R, Yankova, R, Ivanovska, M, Murdjeva, M, Popova, T, Dermendzhiev, S, Karjalainen, M, Lehnigk, U, Brown, D, Locklear, JC, Locklear, J, Maris, I, Hourihane, J, Ornelas, C, Caiado, J, Ferreira, MB, Pereira-Barbosa, M, Puente, Y, Daza, JC, Monteseirin, FJ, Ukleja-Sokolowska, N, Gawronska-Ukleja, E, Zbikowska-Gotz, M, Bartuzi, Z, Sokolowski, L, Adams, A, Mahon, B, English, K, Gourdon-Dubois, N, Sellam, L, Pereira, B, Michaud, E, Messaoudi, K, Evrard, B, Fauquert, J-L, Palomares, F, Gomez, G, Rodriguez, MJ, Galindo, L, Molina, A, Paparo, L, Mennini, M, Aitoro, R, Wawrzeńczyk, A, Przybyszewski, M, Sarıcoban, HE, Ugras, M, Yalvac, Z, Flokstra-de Blok, BMJ, van der Velde, JL, Vereda, A, Ippolito, C, Traversa, A, Adriano, D, Bianchi, DM, Gallina, S, Decastelli, L, Makatsori, M, Miles, A, Devetak, SP, Devetak, I, Tabet, SA, Trandbohus, JF, Winther, P, Malling, H-J, Hansen, KS, Garvey, 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Bridts, CH, De Clerck, LS, Ebo, D, Schwarz, S, Ziegert, M, Albroscheit, S, Schwager, C, Kull, S, Behrends, J, Röckendorf, N, Schocker, F, Frey, A, Homann, A, Becker, W-M, Jappe, U, Zaabat, N, Osscini, S, Agabriel, C, Sterling, B, Carsin, A, Liabeuf, V, Maćków, M, Zbróg, A, Bronkowska, M, Courtois, J, Gadisseur, R, Bertholet, C, Lukas, P, Cavalier, E, Delahaut, P, Quinting, B, Gertmo, MB, Hasseus, ET, Barzylovych, V, Oliveira, J, Ensina, LF, Aranda, CS, Dopazo, L, Lopez, R, Perez, R, Santos-Diez, L, Bilbao, A, Garcia, JM, Núñez, IG, Mármol, MÁA, Villarejo, MJB, Martos, JAB, Vergara, MS, García, JMI, Michalska, A, Sergiejko, G, Zacniewski, R, Ghiordanescu, I-M, Deaconu, C, Popescu, M, Bumbacea, RS, Ibranji, A, Nikolla, E, Loloci, G, Juel-Berg, N, Larsen, LF, Poulsen, LK, Marcelino, J, Prata, R, Costa, AC, Duarte, F, Neto, M, Santos, J, Pestana, LC, Sampaio, D, Minale, P, Dignetti, P, Bignardi, D, Nedelea, I, Popescu, F-D, Vieru, M, Secureanu, F-A, Ganea, CS, Vieira, M, Silva, JPM, Watts, T, Watts, S, Lomikovska, M, Peredelskaya, M, Nenasheva, N, Filipovic, I, Zivkovic, Z, Filipovic, D, Higgs, J, Warner, A, and Jones, C
- Published
- 2017
17. Nanoparticle guests in lyotropic liquid crystals
- Author
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Dölle, S., Park, J. H., Schymura, S., Scalia, G., and Lagerwall, J. P. F.
- Subjects
carbon nanotubes ,Flüssigkristalle ,Nanopartikel ,nanoparticles ,lyotrope ,lyotropic liquid crystals ,Kohlenstoffnanoröhrchen - Abstract
In this chapter we discuss the benefits, peculiarities and main challenges related to nanoparticle templating in lyotropic liquid crystals. We first give a brief bird’s-eye view of the field, discussing di↵erent nanoparticles as well as di↵erent lyotropic hosts that have been explored, but then quickly focus on the dispersion of carbon nanotubes in surfactant-based lyotropic nematic phases. We discuss in some detail how the trans- fer of orientational order from liquid crystal host to nanoparticle guest can be verified and which degree of ordering can be expected, as well as the importance of choosing the right surfactant and its concentra- tion for the stability of the nanoparticle suspension. We introduce a method for dispersing nanoparticles with an absolute minimum of stabi- lizing surfactant, based on dispersion below the Kra↵t temperature, and we discuss the peculiar phenomenon of filament formation in lyotropic nematic phases with a su cient concentration of well-dispersed carbon nanotubes. Finally, we describe how the total surfactant concentration in micellar nematics can be greatly reduced by combining cat- and an- ionic surfactants, and we discuss how nanotubes can help in inducing the liquid crystal phase close to the isotropic–nematic boundary.
- Published
- 2016
18. Anaphylaxis in children and adolescents: The European Anaphylaxis Registry
- Author
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Grabenhenrich, L.B. Dölle, S. Moneret-Vautrin, A. Köhli, A. Lange, L. Spindler, T. Ruëff, F. Nemat, K. Maris, I. Roumpedaki, E. Scherer, K. Ott, H. Reese, T. Mustakov, T. Lang, R. Fernandez-Rivas, M. Kowalski, M.L. Bilò, M.B. Hourihane, J.O. Papadopoulos, N.G. Beyer, K. Muraro, A. Worm, M.
- Abstract
Background Anaphylaxis in children and adolescents is a potentially life-threatening condition. Its heterogeneous clinical presentation and sudden occurrence in virtually any setting without warning have impeded a comprehensive description. Objective We sought to characterize severe allergic reactions in terms of elicitors, symptoms, emergency treatment, and long-term management in European children and adolescents. Methods The European Anaphylaxis Registry recorded details of anaphylaxis after referral for in-depth diagnosis and counseling to 1 of 90 tertiary allergy centers in 10 European countries, aiming to oversample the most severe reactions. Data were retrieved from medical records by using a multilanguage online form. Results Between July 2007 and March 2015, anaphylaxis was identified in 1970 patients younger than 18 years. Most incidents occurred in private homes (46%) and outdoors (19%). One third of the patients had experienced anaphylaxis previously. Food items were the most frequent trigger (66%), followed by insect venom (19%). Cow's milk and hen's egg were prevalent elicitors in the first 2 years, hazelnut and cashew in preschool-aged children, and peanut at all ages. There was a continuous shift from food- to insect venom- and drug-induced anaphylaxis up to age 10 years, and there were few changes thereafter. Vomiting and cough were prevalent symptoms in the first decade of life, and subjective symptoms (nausea, throat tightness, and dizziness) were prevalent later in life. Thirty percent of cases were lay treated, of which 10% were treated with an epinephrine autoinjector. The fraction of intramuscular epinephrine in professional emergency treatment increased from 12% in 2011 to 25% in 2014. Twenty-six (1.3%) patients were either admitted to the intensive care unit or had grade IV/fatal reactions. Conclusions The European Anaphylaxis Registry confirmed food as the major elicitor of anaphylaxis in children, specifically hen's egg, cow's milk, and nuts. Reactions to insect venom were seen more in young adulthood. Intensive care unit admissions and grade IV/fatal reactions were rare. The registry will serve as a systematic foundation for a continuous description of this multiform condition. © 2016 American Academy of Allergy, Asthma & Immunology.
- Published
- 2016
19. Beweisführung – diagnostische Diäten im Erwachsenenalter
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Dölle, S., primary, Grünhagen, J., additional, and Worm, M., additional
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- 2016
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20. Dem Täter auf der Spur: Indikation und praktische Umsetzung von Nahrungsmittelprovokationen im Erwachsenenalter
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Dölle, S., primary, Grünhagen, J., additional, and Worm, M., additional
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- 2016
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21. Nahrungsmittelanaphylaxie. Daten aus dem deutschsprachigen Anaphylaxie- Register 2006 – 2015
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Worm, M., primary, Grünhagen, J., additional, and Dölle, S., additional
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- 2016
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22. Triggers and treatment of anaphylaxis: an analysis of 4,000 cases from Germany, Austria and Switzerland
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Worm, M, Eckermann, O, Dölle, S, Aberer, W, Worm, M, Eckermann, O, Dölle, S, and Aberer, W
- Abstract
Background: Anaphylaxis is the most severe manifestation of a mast cell–dependent immediate reaction and may be fatal. According to data from the Berlin region, its incidence is 2–3 cases per 100 000 persons per year. Methods: We evaluated data from the anaphylaxis registry of the German-speaking countries for 2006–2013 and data from the protocols of the ADAC air rescue service for 2010–2011 to study the triggers, clinical manifestations, and treatment of anaphylaxis. Results: The registry contained data on 4141 patients, and the ADAC air rescue protocols concerned 1123 patients. In the registry, the most common triggers for anaphylaxis were insect venom (n = 2074; 50.1%), foods (n = 1039; 25.1%), and drugs (n = 627; 15.1%). Within these groups, the most common triggers were wasp (n = 1460) and bee stings (n = 412), legumes (n = 241), animal proteins (n = 225), and analgesic drugs (n = 277). Food anaphylaxis was most frequently induced by peanuts, cow milk, and hen's egg in children and by wheat and shellfish in adults. An analysis of the medical emergency cases revealed that epinephrine was given for grade 3 or 4 anaphylaxis to 14.5% and 43.9% (respectively) of the patients in the anaphylaxis registry and to 19% and 78% of the patients in the air rescue protocols. Conclusion: Wasp and bee venom, legumes, animal proteins, and analgesic drugs were the commonest triggers of anaphylaxis. Their relative frequency was age-dependent. Epinephrine was given too rarely, as it is recommended in the guidelines for all cases of grade 2 and above.
- Published
- 2014
23. Allergische Reaktionen nach Backwaren – nicht immer Weizen
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Dölle, S., primary, Grünhagen, J., additional, and Worm, M., additional
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- 2014
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24. Risikofaktoren für schwere Reaktionen und Anaphylaxie
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Worm, M., primary, Dölle, S., additional, Nassiri, M., additional, and Babina, M., additional
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- 2014
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25. Nahrungsmittelallergie infolge immunologischer Kreuzreaktivitäten mit Inhalationsallergenen
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Worm, M., primary, Jappe, U., additional, Kleine-Tebbe, J., additional, Schäfer, C., additional, Reese, I., additional, Saloga, J., additional, Treudler, R., additional, Zuberbier, T., additional, Wassmann, A., additional, Fuchs, T., additional, Dölle, S., additional, Raithel, M., additional, Ballmer-Weber, B., additional, Niggemann, B., additional, and Werfel, T., additional
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- 2014
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26. Sellerieinduzierte Anaphylaxie
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Dölle, S., primary, Grünhagen, J., additional, and Worm, M., additional
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- 2013
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27. Elicitors and cofactors of food-induced anaphylaxis
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Hompes, S, primary, Grabenhenrich, L, additional, Grünhagen, J, additional, Dölle, S, additional, and Worm, M, additional
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- 2013
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28. Cabbage Allergy: A Rare Cause of Food-induced Anaphylaxis
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Dölle, S, primary, Hompes, S, additional, Lange, L, additional, and Worm, M, additional
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- 2013
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29. Nahrungsmittelassoziierte Anaphylaxie
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Dölle, S., primary, Hompes, S., additional, Grünhagen, J., additional, and Worm, M., additional
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- 2012
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30. Immuntherapie II
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Diethers, A., primary, Hecker, J., additional, Seismann, H., additional, Etzold, S., additional, Michel, Y., additional, Plum, M., additional, Blank, S., additional, Bredehorst, R., additional, Braren, I., additional, Spillner, E., additional, Käding, M., additional, Dölle, S., additional, Berg, J., additional, Rasche, C., additional, Worm, M., additional, Egert-Schmidt, A.-M., additional, Martin, E., additional, Müller, J., additional, Schulte, M., additional, Thum-Oltmer, S., additional, Wald, M., additional, Pump, L., additional, Hagen, S., additional, Suck, R., additional, Cromwell, O., additional, Nandy, A., additional, Engst, R., additional, Ahrens, P., additional, Distler, A., additional, Pafferath, B., additional, Lumovici, J., additional, Rak, S., additional, Valovirta, E., additional, Augustin, S., additional, Stock, M., additional, Reese, G., additional, Köhler, H.-J., additional, Straub, D., additional, Brehler, R., additional, Sager, A., additional, Klein, C., additional, Reiber, R., additional, Wolf, H., additional, Schnitker, J., additional, Wüstenberg, E., additional, Becker, F., additional, Becker, S., additional, Schwab, J.-A., additional, Gronke, C., additional, Diemer, S., additional, Fröhlich, S., additional, Geidel, C., additional, Lauener, R., additional, Ring, J., additional, and Möhrenschlager, M., additional
- Published
- 2011
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31. Exogenous Histamine Aggravates Eczema in a Subgroup of Patients with Atopic Dermatitis
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Worm, M, primary, Fiedler, E, additional, Dölle, S, additional, Schink, T, additional, Hemmer, W, additional, Jarisch, R, additional, and Zuberbier, T, additional
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- 2009
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32. Nahrungsmittelallergene
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Reuter, F., primary, Bade, S., additional, Hirst, T., additional, Becker, W., additional, Frey, A., additional, Adler, H. S., additional, Hofmann, C., additional, Christ, S., additional, Raps, C., additional, Scheurer, S., additional, Vieths, S., additional, Steinbrink, K., additional, Krüger, U., additional, Buhl, T., additional, Hänßle, H., additional, Fuchs, T., additional, Süß, A., additional, Treudler, R., additional, Averbeck, M., additional, Simon, J., additional, Gorris, H., additional, McIntyre, M., additional, Mohammad-Gholiei, M., additional, Eberlein, B., additional, Ollert, M., additional, Ring, J., additional, Darsow, U., additional, Dölle, S., additional, Schwarz, D., additional, Lehmann, K., additional, Bäßler, O., additional, Franken, P., additional, George, E., additional, Worm, M., additional, Stratmann, C., additional, Fölster-Holst, R., additional, Kühne, Y., additional, Ballmer-Weber, B., additional, Niggemann, B., additional, Scibilia, J., additional, Reese, G., additional, Holzhauser, T., additional, Lorenz, Y., additional, Le Quynh, L., additional, Mahler, V., additional, Foetisch, K., additional, Enrique, E., additional, Bartra, J., additional, and Biemelt, S., additional
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- 2007
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33. Hauterkrankungen — Juckreiz — Anaphylaxie
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Jappe, U., primary, Schulz, J., additional, Lonsdorf, A., additional, Hartschuh, W., additional, Mansfeld, H. J., additional, Schramedei, R., additional, Manstein, P., additional, Pfab, F., additional, Riphoff, E., additional, Huss-Marp, J., additional, Behrendt, H., additional, Ring, J., additional, Darsow, U., additional, Valet, M., additional, Sprenger, T., additional, Zimmer, C., additional, Tölle, T., additional, Rings, J., additional, Gatti, A., additional, Fuqin, J., additional, Irnich, D., additional, Athanasiadis, G., additional, End, K., additional, Nemat, K., additional, Pyper, A., additional, Gahr, M., additional, Dölle, S., additional, Koch, C., additional, Rasche, C., additional, Jungclas, H., additional, Renz, H., additional, Worm, M., additional, Schmitt, J., additional, Meurer, M., additional, Schwanebeck, U., additional, Grählert, X., additional, Schäkel, K., additional, Walker, A., additional, Geier, J., additional, Przybilla, B., additional, Ruëff, F., additional, Schölermann, A., additional, Roos, T., additional, Scherdin, U., additional, Traupe, B., additional, Bohnsack, K., additional, Filbry, A., additional, Rippke, F., additional, Riffelmann, F., additional, Wenzel, M., additional, Pfeiff, B., additional, Schupp, P., additional, Firnhaber, C., additional, Knott, E., additional, Dendorfer, M., additional, Eben, R., additional, Weimer, G., additional, Flaig, M., additional, Sachs, B., additional, Fischer-Barth, W., additional, Merk, H., additional, Treudler, R., additional, Kozovska, Y., additional, Averbeck, M., additional, Simon, J., additional, Hompes, S., additional, Vogel, N., additional, Kirschbaum, J., additional, Jofer, C., additional, Brockow, K., additional, and Schnadt, S., additional
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- 2007
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34. Nahrungsmittel/Gastrointestinaltrakt
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Riecken, S., primary, Schmidt, H., additional, Darcan, Y., additional, Janssen, O., additional, Becker, W., additional, Adler, H. S., additional, Christ, S., additional, Raps, C., additional, Hofmann, C., additional, Scheurer, S., additional, Vieths, S., additional, Steinbrink, K., additional, Ilchmann, A., additional, Waibler, Z., additional, Kalinke, U., additional, Toda, M., additional, Hompes, S., additional, Behrendt, N., additional, Schoepke, N., additional, Dölle, S., additional, Zuberbier, T., additional, Worm, M., additional, Dolle, S., additional, and Fiedler, E., additional
- Published
- 2007
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35. Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
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Pouessel G, Claverie C, Labreuche J, Renaudin J, Dorkenoo A, Eb M, Moneret-Vautrin A, Deschildre A, Leteurtre S, Grabenhenrich L, Worm M, Dölle S, and Jones C
36. Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
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Pouessel G, Claverie C, Labreuche J, Renaudin J, Dorkenoo A, Eb M, Moneret-Vautrin A, Deschildre A, Leteurtre S, Grabenhenrich L, Worm M, Dölle S, and Jones C
37. Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
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Pouessel G, Claverie C, Labreuche J, Renaudin J, Dorkenoo A, Eb M, Moneret-Vautrin A, Deschildre A, Leteurtre S, Grabenhenrich L, Worm M, Dölle S, Scherer K, Hutteger I, Christensen M, Bindslev-Jensen C, Mortz C, Eller E, Hf, Kjaer, and Jones C
38. Modulation of the immune reponse to subcutaneous grass pollen-specific immunotherapy by vitamin D – data from a controlled clinical pilot trial.
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Heine, G., Francuzik, W., Dölle, S., Drozdenko, G., Schumacher, N., Bacher, P., Scheffold, A., Radbruch, A., and Worm, M.
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- 2017
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39. Proximity-Based Emergency Response Communities for Patients With Allergies Who Are at Risk of Anaphylaxis: Clustering Analysis and Scenario-Based Survey Study.
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Gaziel Yablowitz M, Dölle S, Schwartz DG, and Worm M
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- Adult, Anaphylaxis epidemiology, Anaphylaxis etiology, Cluster Analysis, Emergency Medical Services standards, Emergency Medical Services statistics & numerical data, Epinephrine administration & dosage, Epinephrine therapeutic use, Female, Germany epidemiology, Humans, Israel epidemiology, Male, Middle Aged, Surveys and Questionnaires, Anaphylaxis therapy, Emergency Medical Services classification
- Abstract
Background: Anaphylaxis is a potentially fatal allergic reaction. However, many patients at risk of anaphylaxis who should permanently carry a life-saving epinephrine auto injector (EAI) do not carry one at the moment of allergen exposure. The proximity-based emergency response communities (ERC) strategy suggests speeding EAI delivery by alerting patient-peers carrying EAI to respond and give their EAI to a nearby patient in need., Objectives: This study had two objectives: (1) to analyze 10,000 anaphylactic events from the European Anaphylaxis Registry (EAR) by elicitor and location in order to determine typical anaphylactic scenarios and (2) to identify patients' behavioral and spatial factors influencing their response to ERC emergency requests through a scenario-based survey., Methods: Data were collected and analyzed in two phases: (1) clustering 10,000 EAR records by elicitor and incident location and (2) conducting a two-center scenario-based survey of adults and parents of minors with severe allergy who were prescribed EAI, in Israel and Germany. Each group received a four-part survey that examined the effect of two behavioral constructs-shared identity and diffusion of responsibility-and two spatial factors-emergency time and emergency location-in addition to sociodemographic data. We performed descriptive, linear correlation, analysis of variance, and t tests to identify patients' decision factors in responding to ERC alerts., Results: A total of 53.1% of EAR cases were triggered by food at patients' home, and 46.9% of them were triggered by venom at parks. Further, 126 Israeli and 121 German participants completed the survey and met the inclusion criteria. Of the Israeli participants, 80% were parents of minor patients with a risk of anaphylaxis due to food allergy; their mean age was 32 years, and 67% were women. In addition, 20% were adult patients with a mean age of 21 years, and 48% were female. Among the German patients, 121 were adults, with an average age of 47 years, and 63% were women. In addition, 21% were allergic to food, 75% were allergic to venom, and 2% had drug allergies. The overall willingness to respond to ERC events was high. Shared identity and the willingness to respond were positively correlated (r=0.51, P<.001) in the parent group. Parents had a stronger sense of shared identity than adult patients (t
243 = -9.077, P<.001). The bystander effect decreased the willingness of all patients, except the parent group, to respond (F1,269 =28.27, P<.001). An interaction between location and time of emergency (F1,473 =77.304, P<.001) revealed lower levels of willingness to respond in strange locations during nighttime., Conclusions: An ERC allergy app has the potential to improve outcomes in case of anaphylactic events, but this is dependent on patient-peers' willingness to respond. Through a two-stage process, our study identified the behavioral and spatial factors that could influence the willingness to respond, providing a basis for future research of proximity-based mental health communities., (©Michal Gaziel Yablowitz, Sabine Dölle, David G Schwartz, Margitta Worm. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 22.08.2019.)- Published
- 2019
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40. Wissensstand zur Anaphylaxie und Umgang mit Adrenalinautoinjektoren in Apotheken.
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Worm M, Molaie N, and Dölle S
- Abstract
Hintergrund: Adrenalin intramuskulär mit Hilfe eines Autoinjektors ist das Mittel der Wahl zur Selbstbehandlung schwerer allergischer Reaktionen. Zahlen aus dem Anaphylaxie-Register zeigen, dass Adrenalinautoinjektoren selten von Patienten eingesetzt werden. Apotheker sind eine wichtige Schnittstelle zwischen verordnendem Arzt und Patienten., Patienten Und Methodik: Ziel der vorliegenden Arbeit war es, den Wissensstand bei Apothekern zur Anaphylaxie und deren Behandlung mittels definierter Wissensfragen strukturiert zu erheben. Hierzu wurden Daten von einer standardisierten Fragebogenerhebung von 213 Apotheken analysiert., Ergebnisse: Die Daten zeigen, dass Apotheker die Anaphylaxie als eine Erkrankung mit reduzierter Lebensqualität einschätzen. Die Benennung der häufigsten Auslöser einer Anaphylaxie durch die Apotheker entspricht den Daten aus dem Anaphylaxie-Register (Insektengift, Nahrungsmittel und Medikamente). Die Auswertung zum Wissensstand der Apotheker zeigt, dass Fallbeschreibungen einer Anaphylaxie richtig zugeordnet werden können. Es bestehen jedoch Wissensdefizite bei Fragen zur Behandlung einer Anaphylaxie mit Adrenalin und zu den Leitlinien., Schlussfolgerungen: Die vorliegende Untersuchung zeigt, dass der Wissensstand von Apothekern zur Anaphylaxie verbessert werden kann. Da Apotheker eine wesentliche Schnittstelle bei der Versorgung von Patienten mit allergischen Erkrankungen darstellen, sollte Ziel weiterführender Maßnahmen sein, diese Schnittstelle durch Aufklärungs- und Schulungsmodule zu verstärken, um somit die Patientenversorgung zu verbessern., (© 2018 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.)
- Published
- 2018
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41. Level of knowledge among pharmacists regarding anaphylaxis and the use of epinephrine autoinjectors.
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Worm M, Molaie N, and Dölle S
- Subjects
- Humans, Injections, Intramuscular, Self Administration, Surveys and Questionnaires, Adrenergic alpha-Agonists administration & dosage, Anaphylaxis drug therapy, Epinephrine administration & dosage, Health Knowledge, Attitudes, Practice, Pharmacists
- Abstract
Background: Epinephrine autoinjectors for intramuscular administration are the treatment of choice for self-medicating severe allergic reactions. Data from the anaphylaxis registry shows that patients rarely use their epinephrine pens. Pharmacists play a key role as liaison between prescribers and patients., Patients and Methods: Using a standardized questionnaire, the objective of the present study was to assess the level of knowledge among pharmacists regarding anaphylaxis and its treatment. Data derived from 213 pharmacists was included in the study., Results: Our data reveals that pharmacists consider anaphylaxis to be a disorder that is associated with an impairment in quality of life. The most common triggers of anaphylaxis according to pharmacists (insect venom, foods, and drugs) correspond to those listed in the anaphylaxis registry. Based on the survey, pharmacists readily recognize anaphylactic reactions from case descriptions. However, there are still knowledge deficits with respect to the management of anaphylaxis and current guidelines., Conclusions: Our findings suggest that the level of knowledge among pharmacists with regard to anaphylaxis warrants improvement. As this professional group plays a crucial part in the care of patients with allergic disorders, future measures should be aimed at strengthening this role by raising awareness and introducing training modules., (© 2018 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.)
- Published
- 2018
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42. Epinephrine in Severe Allergic Reactions: The European Anaphylaxis Register.
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Grabenhenrich LB, Dölle S, Ruëff F, Renaudin JM, Scherer K, Pföhler C, Treudler R, Koehli A, Mahler V, Spindler T, Lange L, Bilò MB, Papadopoulos NG, Hourihane JOB, Lang R, Fernández-Rivas M, Christoff G, Cichocka-Jarosz E, and Worm M
- Subjects
- Adolescent, Adult, Aged, Child, Child, Preschool, Europe, Female, Humans, Infant, Infant, Newborn, Injections, Intramuscular, Male, Middle Aged, Registries, Young Adult, Anaphylaxis drug therapy, Bronchodilator Agents therapeutic use, Epinephrine therapeutic use
- Abstract
Background: Current guidelines recommend intramuscular administration of epinephrine as the first-line drug for the emergency treatment of severe allergic reactions (anaphylaxis), but no randomized trial evidence supports this consensus., Objective: We aimed to assess anaphylaxis treatment practices over 10 years, covering several European regions, all allergen sources, and all age groups., Methods: The European Anaphylaxis Register tracks elicitors, symptoms, emergency treatment, diagnostic workups, and long-term counseling for anaphylaxis incidents through web-based data entry from tertiary allergy specialists, covering information from the emergency respondent, patient, tertiary referral, and laboratory/clinical test results., Results: We analyzed 10,184 anaphylaxis incidents. In total, 27.1% of patients treated by a health professional received epinephrine and, in total, 10.5% received a second dose. Successful administration was less frequent in German-speaking countries (minimum 19.6%) than in Greece, France, and Spain (maximum 66.7%). Over the last decade, epinephrine administration from a health professional almost doubled to reach 30.6% in 2015-2017, half of which was applied intramuscularly. A total of 14.7% of lay- or self-treated cases were treated with an autoinjector. Of those without treatment, 22.4% carried a device for administration. No change in successful administration by lay emergency respondents was found over the last 10 years. Of the reaction and patient characteristics analyzed, only clinical severity considerably influenced the likelihood of receiving epinephrine, with 66.9% of successful administrations in near-fatal (grade IV) reactions., Conclusions: Despite clear recommendations, only a small proportion of anaphylaxis incidents are treated with epinephrine. We demonstrated a slight increase in treated patients when handled by professionals, but stagnation in lay- or self-treated anaphylaxis. The reaction circumstances, the respondent's professional background, and patient characteristics did not explain which reactions were treated., (Copyright © 2018 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2018
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43. Risk factors and treatment of refractory anaphylaxis - a review of case reports.
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Francuzik W, Dölle S, and Worm M
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- Anaphylaxis epidemiology, Humans, Incidence, Practice Guidelines as Topic, Risk Factors, Anaphylaxis diagnosis, Anaphylaxis drug therapy, Epinephrine therapeutic use, Point-of-Care Systems
- Abstract
Introduction: Patients experiencing anaphylaxis who do not recover after treatment with intramuscular adrenaline are regarded as suffering from refractory anaphylaxis. The incidence of refractory anaphylaxis is estimated to range between 3-5% of anaphylaxis cases. The risk factors for refractory anaphylaxis are unknown. Areas covered: In the present analysis, we aimed to evaluate the management and risk factors of refractory anaphylaxis to highlight possible clinical implications for updating current management algorithms. Expert commentary: According to international guidelines, adrenaline given through the intramuscular (i.m.) route is a rapid and safe treatment but may be insufficient. Therefore, defined standardized treatment protocols for such cases of refractory anaphylaxis are needed to optimize the treatment. Point-of-care diagnostics may enable doctors to identify patients experiencing severe, refractory anaphylaxis early in order to initiate intensified critical care treatment.
- Published
- 2018
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44. Non-celiac gluten/wheat sensitivity (NCGS)-a currently undefined disorder without validated diagnostic criteria and of unknown prevalence: Position statement of the task force on food allergy of the German Society of Allergology and Clinical Immunology (DGAKI).
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Reese I, Schäfer C, Kleine-Tebbe J, Ahrens B, Bachmann O, Ballmer-Weber B, Beyer K, Bischoff SC, Blümchen K, Dölle S, Enck P, Enninger A, Huttegger I, Lämmel S, Lange L, Lepp U, Mahler V, Mönnikes H, Ockenga J, Otto B, Schnadt S, Szepfalusi Z, Treudler R, Wassmann-Otto A, Zuberbier T, Werfel T, and Worm M
- Abstract
Within the last decade, non-celiac gluten/wheat sensitivity (NCGS) has been increasingly discussed not only in the media but also among medical specialties. The existence and the possible triggers of NCGS are controversial. Three international expert meetings which proposed recommendations for NCGS were not independently organized and only partially transparent regarding potential conflicts of interest of the participants. The present position statement reflects the following aspects about NCGS from an allergist's and nutritionist's point of view: (A) Validated diagnostic criteria and/or reliable biomarkers are still required. Currently, this condition is frequently self-diagnosed, of unknown prevalence and non-validated etiology. (B) Gluten has not been reliably identified as an elicitor of NCGS because of high nocebo and placebo effects. Double-blind, placebo-controlled provocation tests are of limited value for the diagnosis of NCGS and should be performed in a modified manner (changed relation of placebo and active substance). (C) Several confounders hamper the assessment of subjective symptoms during gluten-reduced or gluten-free diets. Depending on the selection of food items, e.g., an increased vegetable intake with soluble fibers, diets may induce physiological digestive effects and can modify gastrointestinal transit times independent from the avoidance of gluten. (D) A gluten-free diet is mandatory in celiac disease based on scientific evidence. However, a medically unjustified avoidance of gluten may bear potential disadvantages and risks. (E) Due to a lack of diagnostic criteria, a thorough differential diagnostic work-up is recommended when NCGS is suspected. This includes a careful patient history together with a food-intake and symptom diary, if necessary an allergy diagnostic workup and a reliable exclusion of celiac disease. We recommend such a structured procedure since a medically proven diagnosis is required before considering the avoidance of gluten., Competing Interests: The authors declare that they have no competing interests.
- Published
- 2018
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45. Pharmacokinetic Evaluation of a Single Intramuscular High Dose versus an Oral Long-Term Supplementation of Cholecalciferol.
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Wylon K, Drozdenko G, Krannich A, Heine G, Dölle S, and Worm M
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- Administration, Oral, Adult, Cholecalciferol pharmacokinetics, Cohort Studies, Female, Humans, Injections, Intramuscular, Male, Vitamin D analogs & derivatives, Vitamin D blood, Cholecalciferol administration & dosage
- Abstract
Background and Objectives: Vitamin D deficiency is frequent during the winter and occurs throughout the year in the elderly or patients suffering from autoimmune diseases. The objective of this study was to evaluate the pharmacokinetic properties of oral supplementation versus a single intramuscular injection of cholecalciferol in healthy individuals., Research Design and Methods: Up to 8,000 I.U. oral cholecalciferol was administered daily for 84 days in a 4 week dose-escalation setting to vitamin D deficient individuals. In another cohort, a single intramuscular injection of 100,000 I.U. cholecalciferol was given. In both cohorts, individuals without vitamin D intake served as the comparison group. 25-hydroxyvitamin D (25(OH)D) concentrations were measured in all individuals at defined time points throughout the studies., Results: The mean 25(OH)D serum concentration increased significantly after oral cholecalciferol intake compared to the control group (day 28: 83.4 nmol/l and 42.5 nmol/l; day 56: 127.4 nmol/l and 37.3 nmol/l; day 84: 159.7 nmol/l and 30.0 nmol/l). In individuals receiving 100,000 I.U. cholecalciferol intramuscular, the mean 25(OH)D serum concentration peaked after 4 weeks measuring 70.9 nmol/l compared to 32.7 nmol/l in the placebo group (p = 0.002). The increase of 25(OH)D serum concentrations after 28 days was comparable between both routes of administration (p = 0.264)., Conclusions: Oral and intramuscular cholecalciferol supplementation effectively increased serum 25(OH)D concentrations., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2017
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46. New trends in anaphylaxis.
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Worm M, Sturm G, Kleine-Tebbe J, Cichocka-Jarosz E, Cardona V, Maris I, and Dölle S
- Abstract
This review presents the current trends in anaphylaxis management discussed at the fourth International Network for Online-Registration of Anaphylaxis (NORA) conference held in Berlin in April 2017. Current data from the anaphylaxis registry show that Hymenoptera venom, foods, and pharmaceutical drugs are still among the most frequent triggers of anaphylaxis. Rare triggers include chicory, cardamom, asparagus, and goji berries. A meta-analysis on recent trends in insect venom anaphylaxis demonstrated for the first time that, although data on the efficacy of insect venom immunotherapy is limited, the occurrence of severe reactions upon repeated sting events can be prevented and patients' quality of life improved. Molecular diagnostics of insect venom anaphylaxis have significantly improved diagnostic sensitivity and specificity. Self-treatment of anaphylaxis is of great importance. Recent data from the anaphylaxis registry show an increase (from 23% in 2012 to 29% in 2016) in the use of adrenaline as recommended in the guidelines. A survey on the implementation of guidelines conducted among the centers reporting to the anaphylaxis registry highlights the extent to which the guideline has been perceived and implemented. Reports on a variety of cases in the anaphylaxis registry illustrate the diversity of this potentially life-threatening reaction. Component-resolved diagnostics can help to specify sensitization profiles in anaphylaxis, particularly in terms of the risk for severe reactions. Recent studies on anaphylaxis awareness show that training methods are effective; nevertheless, target groups and learning methods need to undergo further scientific investigation in coming years.
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- 2017
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47. Polyethylene glycol as a cause of anaphylaxis.
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Wylon K, Dölle S, and Worm M
- Abstract
Background: Polyethylene glycols (PEGs) or macrogols are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics, and food., Case Report: We report on a Caucasian patient experiencing recurrent severe allergic reactions to several drugs. An extensive diagnostic workup including skin prick tests, intradermal tests (IDT) and a double-blind oral challenge was performed to identify the trigger of anaphylaxis. In the present case hypersensitivity to the additive polyethylene glycol was confirmed by an IDT suggesting an Immunoglobulin E-dependent mechanism as a cause of the reaction., Conclusion: Potential life-threatening hypersensitivity reactions to hidden molecules like macrogol may be underdiagnosed. Cases of immediate-type PEG hypersensitivity were reported with increasing frequency. The awareness regarding the allergenic potential of PEG should be raised and a proper product labelling is crucial to prevent PEG mediated hypersensitivity.
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- 2016
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48. Exploratory analysis of CD63 and CD203c expression in basophils from hazelnut sensitized and allergic individuals.
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Lötzsch B, Dölle S, Vieths S, and Worm M
- Abstract
Background: Sensitization to hazelnut (HN) is frequent and requires clarification to determine whether this sensitization is clinically relevant. The aim of this study was to investigate basophil activation profiles in HN-sensitized and allergic subjects., Methods: Basophil activation was determined by flow cytometric analyses of CD63 and CD203c expression using several HN allergen concentrations. Depending on their clinical reaction pattern, an oral allergy symptom group (OAS, n = 20), a systemic reaction group (n = 12) and a sensitized group without clinical symptoms (n = 20) were identified. Additionally, 10 non-allergic and non-sensitized individuals served as controls., Results: CD63 and CD203c expression differed between allergic (OAS and systemic group) and sensitized subjects. The HN concentration required to activate 30% of CD203c
+ basophils [effective concentration (EC)30] was significantly higher in sensitized versus the allergic group (p = 0.0089). This was more pronounced when the basophil allergen threshold sensitivity (CD-sens) was calculated (CD63: p = 0.018; CD203c: p = 0.009)., Conclusion: Our data indicate that the basophil activation test may provide information to better distinguish between sensitized and allergic subjects if several allergen concentrations are considered. CD203c expression displayed a better discrimination compared to CD63; therefore, its diagnostic value might be superior compared with CD63.- Published
- 2016
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49. [Food-induced anaphylaxis - data from the anaphylaxis registry].
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Worm M, Grünhagen J, and Dölle S
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Anaphylaxis diagnosis, Causality, Child, Child, Preschool, Comorbidity, Europe epidemiology, Female, Food Hypersensitivity diagnosis, Germany epidemiology, Humans, Infant, Infant, Newborn, Male, Middle Aged, Prevalence, Risk Factors, Survival Rate, Young Adult, Anaphylaxis mortality, Food Hypersensitivity mortality, Registries
- Abstract
Anaphylactic reactions due to food occur in the context of food allergy and, together with venom and drugs, are the most frequent elicitors of severe allergic reactions. In small children the most frequent elicitors of severe allergic reactions according to data from the anaphylaxis registry are hen's egg and milk, whereas in school children peanut and hazelnut are frequent elicitors of allergic reactions. Other frequent elicitors of anaphylactic reactions in childhood are wheat and soy. In adults the most frequent elicitors of severe allergic reactions due to food, based on data from the anaphylaxis registry, are wheat, soy, celery, shellfish and hazelnut. Rare elicitors of food-induced anaphylaxis in German-speaking countries are mustard and cabbage. However, the panel of rare elicitors of food-induced anaphylaxis show regional differences. As of March 2015, 17 cases of fatal anaphylaxis were registered and among these seven were food-induced. Co-factors can either trigger the elicitation of a severe allergic reaction or affect its severity. Among such co-factors are physical activity, the intake of certain drugs, and psychological stress. The data on the role of cofactors is sparse. The management of food-induced anaphylaxis includes acute management according to current guidelines, but also long-term management, which should include educational measures regarding treatment but also information about the food allergen in daily life.
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- 2016
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50. Anaphylaxis in children and adolescents: The European Anaphylaxis Registry.
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Grabenhenrich LB, Dölle S, Moneret-Vautrin A, Köhli A, Lange L, Spindler T, Ruëff F, Nemat K, Maris I, Roumpedaki E, Scherer K, Ott H, Reese T, Mustakov T, Lang R, Fernandez-Rivas M, Kowalski ML, Bilò MB, Hourihane JO, Papadopoulos NG, Beyer K, Muraro A, and Worm M
- Subjects
- Adolescent, Child, Child, Preschool, Emergency Treatment, Europe epidemiology, Female, Health Care Surveys, Health Surveys, Humans, Infant, Infant, Newborn, Male, Registries, Retrospective Studies, Anaphylaxis diagnosis, Anaphylaxis epidemiology, Anaphylaxis etiology, Anaphylaxis therapy
- Abstract
Background: Anaphylaxis in children and adolescents is a potentially life-threatening condition. Its heterogeneous clinical presentation and sudden occurrence in virtually any setting without warning have impeded a comprehensive description., Objective: We sought to characterize severe allergic reactions in terms of elicitors, symptoms, emergency treatment, and long-term management in European children and adolescents., Methods: The European Anaphylaxis Registry recorded details of anaphylaxis after referral for in-depth diagnosis and counseling to 1 of 90 tertiary allergy centers in 10 European countries, aiming to oversample the most severe reactions. Data were retrieved from medical records by using a multilanguage online form., Results: Between July 2007 and March 2015, anaphylaxis was identified in 1970 patients younger than 18 years. Most incidents occurred in private homes (46%) and outdoors (19%). One third of the patients had experienced anaphylaxis previously. Food items were the most frequent trigger (66%), followed by insect venom (19%). Cow's milk and hen's egg were prevalent elicitors in the first 2 years, hazelnut and cashew in preschool-aged children, and peanut at all ages. There was a continuous shift from food- to insect venom- and drug-induced anaphylaxis up to age 10 years, and there were few changes thereafter. Vomiting and cough were prevalent symptoms in the first decade of life, and subjective symptoms (nausea, throat tightness, and dizziness) were prevalent later in life. Thirty percent of cases were lay treated, of which 10% were treated with an epinephrine autoinjector. The fraction of intramuscular epinephrine in professional emergency treatment increased from 12% in 2011 to 25% in 2014. Twenty-six (1.3%) patients were either admitted to the intensive care unit or had grade IV/fatal reactions., Conclusions: The European Anaphylaxis Registry confirmed food as the major elicitor of anaphylaxis in children, specifically hen's egg, cow's milk, and nuts. Reactions to insect venom were seen more in young adulthood. Intensive care unit admissions and grade IV/fatal reactions were rare. The registry will serve as a systematic foundation for a continuous description of this multiform condition., (Copyright © 2015 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2016
- Full Text
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